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Understanding The Origin, Evolution, And Dynamics Of Transneptunian Binaries, Benjamin C N Proudfoot

Theses and Dissertations

This dissertation discusses research that focuses on understanding transneptunian objects (TNOs) using a variety of techniques and approaches. In Chapter 1, I introduce the main concepts used throughout this dissertation and discuss the current understanding of the transneptunian region. In Chapter 2, I discuss my efforts to understand how Neptune's late stages of migration affect the Haumea family, the only known collisional family in the transneptunian region. Using advanced simulations of Neptune migration, I find that the Haumea family can plausibly form before the termination of giant planet migration and show that this extensively mixes the family. The simplest explanation …

Star, Qian Liao

Theses

This document demonstrates the design process of an Augmented-Reality visual interaction design for improving and enhancing the astronomical observing experience for amateurs. Astronomical observation can be fun and romantic when sharing the experience with friends, family, or someone special. Sharing those magnificent moments with friends and family when astronomical events happen could be joyful. However, there are some inevitable barriers. In order to have a successful meteor shower observation, observers must follow a series of strict and professional rules that make the experience usually unaffordable for amateurs. As a result, I proposed a new way for amateurs that combined user …

Intragenic Egfr::Egfre1e8 Fusion (Egfrviii) In 4331 Solid Tumors, Lan Zheng, Rajyalakshmi Luthra, Hector A Alvarez, F Anthony San Lucas, Dzifa Y Duose, Ignacio I Wistuba, Gregory N Fuller, Leomar Y Ballester, Sinchita Roy-Chowdhuri, Keith J Sweeney, Asif Rashid, Richard K Yang, Wei Chen, Audrey Liu, Yun Wu, Constance Albarracin, Keyur P Patel, Mark J Routbort, Aysegul A Sahin, Qingqing Ding, Hui Chen

Faculty, Staff and Student Publications

Epidermal growth factor receptor variant III (EGFRvIII, the deletion of exons 2-7) is a recurrent intragenic EGFR::EGFR.E1E8 fusion that occurs in high-grade gliomas. The presence of EGFRvIII in other solid tumors has not been well characterized. We retrospectively reviewed advanced malignant solid tumor cases tested by a custom hybrid capture 610-gene next-generation sequencing platform from 2021 to 2022. EGFRvIII was identified in 17 of 4331 (0.4%) cases, including 16 of 238 (7%) brain tumors and 1/301 (0.3%) breast tumors. EGFRvIII-positive brain tumors were all glioblastoma IDH-wildtype, most with concurrent TERT promoter mutation (14 of 16), EGFR amplification (13 of …

1900 Capital Trust Ii V. Johnson

All Decisions

No abstract provided.

Blue-Shift Photoconversion Of Near-Infrared Fluorescent Proteins For Labeling And Tracking In Living Cells And Organisms, Francesca Pennacchietti, Jonatan Alvelid, Rodrigo A Morales, Martina Damenti, Dirk Ollech, Olena S Oliinyk, Daria M Shcherbakova, Eduardo J Villablanca, Vladislav V Verkhusha, Ilaria Testa

Faculty, Staff and Student Publications

Photolabeling of intracellular molecules is an invaluable approach to studying various dynamic processes in living cells with high spatiotemporal precision. Among fluorescent proteins, photoconvertible mechanisms and their products are in the visible spectrum (400-650 nm), limiting their in vivo and multiplexed applications. Here we report the phenomenon of near-infrared to far-red photoconversion in the miRFP family of near infrared fluorescent proteins engineered from bacterial phytochromes. This photoconversion is induced by near-infrared light through a non-linear process, further allowing optical sectioning. Photoconverted miRFP species emit fluorescence at 650 nm enabling photolabeling entirely performed in the near-infrared range. We use miRFPs as …

Front Matter, Iajbs Ateneo De Manila University

Journal of Management for Global Sustainability

N/A

Back Matter, Iajbs Ateneo De Manila University

Journal of Management for Global Sustainability

N/A

¿Cómo Alinear Las Preocupaciones Globales Con Los Problemas Locales?, Pilvi Posio

Journal of Management for Global Sustainability

N/A

Resúmenes, Iajbs Ateneo De Manila University

Journal of Management for Global Sustainability

N/A

Faith Journey - A Collection Of Devotions And Memoirs To Encourage, Anita V. Presnell

Masters Theses

Faith Journey: A Collection of Devotions and Memoirs to Encourage contains relevant personal stories and devotionals, including short and longer devotions accompanied by poetry. My writing aims to pen devotions to encourage others in their walk of faith. The thesis takes the reader on a journey, touching pieces of my life and reflecting on the devotions that I have written. The critical paper is a rhetorical analysis of seminal authors who have written devotions and the way many have touched and shaped my life. The conclusion is that nothing takes the place of time spent with God and in His …

Extended-Synaptotagmin-1 And -2 Control T Cell Signaling And Function, Nathalia Benavides, Claudio G. Giraudo

Department of Microbiology and Immunology Faculty Papers

Upon T-cell activation, the levels of the secondary messenger diacylglycerol (DAG) at the plasma membrane need to be controlled to ensure appropriate T-cell receptor signaling and T-cell functions. Extended-Synaptotagmins (E-Syts) are a family of inter-organelle lipid transport proteins that bridge the endoplasmic reticulum and the plasma membrane. In this study, we identify a novel regulatory mechanism of DAG-mediated signaling for T-cell effector functions based on E-Syt proteins. We demonstrate that E-Syts downmodulate T-cell receptor signaling, T-cell-mediated cytotoxicity, degranulation, and cytokine production by reducing plasma membrane levels of DAG. Mechanistically, E-Syt2 predominantly modulates DAG levels at the plasma membrane in resting-state …

Regulatory Managerialism As Gaslighting Government, Jodi L. Short

Law and Contemporary Problems

No abstract provided.

Power And Knowledge In Policy Evaluation: From Managing Budgets To Analyzing Scenarios, Frank Pasquale

Law and Contemporary Problems

No abstract provided.

Regulation As Respect, Cristie Ford

Law and Contemporary Problems

No abstract provided.

Reclaiming Regulatory Intermediation For The Public, Daniel E. Walters

Law and Contemporary Problems

No abstract provided.

The Anti-Managerial Information Commission, Margaret B. Kwoka

Law and Contemporary Problems

No abstract provided.

A Public Technology Option, Hannah Bloch-Wehba

Law and Contemporary Problems

No abstract provided.

Introduction: Framing Regulatory Managerialism As An Object Of Study And Strategic Displacement, Julile E. Cohen, Ari Ezra Waldman

Law and Contemporary Problems

No abstract provided.

Embrace The Future, Gwendolyn Goguelet

UNH Today Archive

No abstract provided.

Needle Biopsy Accelerates Pro-Metastatic Changes And Systemic Dissemination In Breast Cancer: Implications For Mortality By Surgery Delay, Hiroyasu Kameyama, Priya Dondapati, Reese Simmons, Macall Leslie, John Langenheim, Yunguang Sun, Misung Yi, Aubrey Rottschaefer, Rashmi Pathak, Shreya Nuguri, Kar-Ming Fung, Shirng-Wern Tsaih, Inna Chervoneva, Hallgeir Rui, Takemi Tanaka

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

ncreased breast cancer (BC) mortality risk posed by delayed surgical resection of tumor after diagnosis is a growing concern, yet the underlying mechanisms remain unknown. Our cohort analyses of early-stage BC patients reveal the emergence of a significantly rising mortality risk when the biopsy-to-surgery interval was extended beyond 53 days. Additionally, histology of post-biopsy tumors shows prolonged retention of a metastasis-permissive wound stroma dominated by M2-like macrophages capable of promoting cancer cell epithelial-to-mesenchymal transition and angiogenesis. We show that needle biopsy promotes systemic dissemination of cancer cells through a mechanism of sustained activation of the COX-2/PGE₂/EP2 feedforward loop, …

Global Partnerships In Transformation Of Nursing And Midwifery Education In Africa: A Systematic Scoping Review Protocol, Claudine Muraraneza, Donatilla Mukamana, Godfrey Katende, Oliva Bazirete, Liz Wolvaardt

School of Nursing & Midwifery, East Africa

Background In recent decades, the literature on global partnerships in nursing and midwifery education, for the purpose of enhancing quality of education, strengthening health care system, and achieving universal health coverage is on the rise in Africa. However, there is a gap regarding the best practices and barriers in the African context. The purpose of this systematic scoping review is to map the evidence on global partnerships in transforming nursing and midwifery education in Africa.

Methods A search will be conducted with the use of the following electronic databases: Cumulative Index to Nursing and Applied Health Literature [CINAHL], PubMed, Cochrane …

With Or Without The Table, We Gather: Reinforcing Innate Resiliencies In The African American Family, Jessica L. Stevens-Eddy

Doctoral Dissertations and Projects

This quantitative study aims to determine whether food-sharing (gathering to eat) can be considered a suitable medium to facilitate increased cohesion within African American families. This study focuses on informal food-sharing as an extension of formal meal-sharing. Previous research links consistent formal meal-sharing to positive and secure identity development, better familial attachment, and improved family cohesion. These practices leave a lasting, detrimental impact on the African American family model. Additional barriers to some African American family meal-sharing practices include working extended and atypical work hours, food insecurity, and poor familial communication. There is a lack of research concerning the impact …

Mindfulness For The Reduction Of Anxiety, Stress, And Depression In The Preservice Teacher Community, Shelley R. Crampton

Doctoral Dissertations and Projects

Teachers and students alike suffer from anxiety, stress, and depression. Mindfulness-based strategies have been indicated to help teachers and students deal with stress, anxiety, and depression. Teachers often report not wishing to add more learning strategies to their packed schedules and workload. Education in mindfulness is not easily accessible due to the time constraints of this overworked population. The criteria for participation in the study required the college students in preservice education classes to be over 18 years old, enrolled in the teacher education program, and not have participated in any mindfulness in the last six months. The study is …

The Impact Of Moral Injury On Character Identity For Divorced Catholics: A Character Domain Perspective, Mary Susan Mcauliff

Doctoral Dissertations and Projects

Catholics who are faithful to the teachings of the Catholic Church on the indissolubility of marriage and who experience a civil divorce are at high risk for moral injury. This study was anchored on a character domain theoretical framework, and it investigated the impact of moral injury on character identity (measured by self-discrepancy) through the mediation of the perception of suffering. Religiosity was explored as a moderator for the relationships of moral injury to perception of suffering, perception of suffering to character identity, and moral injury to character identity. Participants (N = 251) were recruited from social media groups, various …

Christological Application Of The Mosaic Law: A Hermeneutical And Exegetical Exploration, Nabeel Saqib

Doctoral Dissertations and Projects

This study is a hermeneutical and exegetical exploration of the Christological application of the Mosaic Law for Christians. It involves a clear understanding of the relationship between the continuity and discontinuity from the Old Testament to the New Testament, the relationship between Israel and the Church as people of God, and the relationship between the Old and the New Covenant. It also requires a clear understanding of the meaning and purpose of the law for the initial audience, and its current significance for Christians today. Romans 10:4 presents Christ as the culmination of the law as it sees him as …

A Phenomenological Approach: How Hopelessness Affects Achievement In The Areas Of Socio-Economic, Criminality, And Educational Success Within The African American Community, Shawn A. Parker

Doctoral Dissertations and Projects

This phenomenological study was designed to examine how the concept of hope or lack thereof has an impact on the negative discrepancies in the areas of education, criminal behavior, and socio-economic status among African Americans as it compares to Whites. There may be other ethnicities who have significant inconsistencies as well, but for the sack of this study, the comparisons were primarily among African Americans and Whites. The theory guiding this study is the psychodynamic approach. This approach was guided by Sigmond Freud’s desire to understand human behavior; provided a path to studying the events of the past and present …

A Case For Offering An Associate Of Fine Arts In Music At Community Colleges In Rural Northwestern And Northern Regions Of North Carolina, Frieda Eakins

Doctoral Dissertations and Projects

This qualitative method research paper with survey design identifies the need to implement an associate in fine arts degree in music at community colleges located in the rural northwestern and northern regions of North Carolina. A music degree would provide early college students with music courses comparable to those offered in traditional area high schools and greater accessibility for a diverse student population of community college students. At the inception of this study, early college high school programs in rural northwestern and northern regions of North Carolina did not offer music courses. Students in these programs relied on the community …

A Phenomenological Study Of African-American Clergys’ Experiences With Mental Health, Rosalind R. Smith

Doctoral Dissertations and Projects

The purpose of this hermeneutical phenomenological qualitative study was to describe African-American clergy’s lived experiences with mental health and mental health’s influence on the construction of their teachings, sermons, and church practice. The goal was to use interpretation to bring to light to an underlying coherence of actions of a group of people. This study reduced individual African-American clergy beliefs regarding mental health to a universal understanding. There were four philosophical assumptions in this study: 1) a search for wisdom to understand the phenomenon of African-American clergy’s lived experiences with mental health influence their teachings, sermons, and church practice, 2) …

A Mixed-Methods Inquiry Into Pastors' Knowledge And Responses To Human Trafficking In Their Congregations In The Baptist Convention Of Maryland/Delaware, Denise A. Beck

Doctoral Dissertations and Projects

The purpose of this mixed-methods study was to discover the knowledge of human trafficking of the pastors in the Baptist Convention of Maryland/Delaware churches and their responses to this crime. The guiding theory was the words of Jesus in Exodus: Chapter 3 concerning slavery and the tribulations of Israelites. A questionnaire provided enlightenment regarding the levels of knowledge in the church communities, how pastors viewed it, the methods by which they received the information, and how they responded to it. This study reflected a gap in the knowledge of pastors in their congregations. The data were collected through emails and …

The Need For A Spiritual Reboot In The Youth Of Great Commission Church, Jean Max B St Louis

Doctoral Dissertations and Projects

The decline of the youth attendance is evident in many Protestant churches. This research paper examined forty-three young believers from three Haitian Baptist churches, respectively, located in Brooklyn, Queens, and the Bronx. These data results help develop a suitable spiritual program that includes the six key influencing factors for spiritual growth: discipleship, mentoring, parental influence, church attendance, personal devotion, and ministerial involvement. This spiritual program was tested on a small group of young people from Great Commission Church in Queens. This research uses a mixed-method methodology, which is a combination of qualitative and quantitative methods to analyze the data. The …