Digital Commons Network^™

Modulatory Effects Of Deacetylated Sialic Acids On Breast Cancer Resistance Protein-Mediated Multidrug Resistance And Receptor Tyrosine Kinase-Targeted Therapy, Isaac Tuffour

Electronic Theses and Dissertations

Multidrug resistance (MDR) remains a major challenge in cancer treatment, accounting for over 90% of chemotherapeutic failures. Cancers utilize sugar residues to engage in multidrug resistance. The underlying mechanism of action involving glycans, specifically the glycan sialic acid (Sia) and its various functional group alterations, has not been explored. ATP-binding cassette (ABC) transporter proteins, key proteins utilized by cancers to engage in MDR pathways, contain Sias in their extracellular domains. Modulating the expression of acetylated-Sias on Breast Cancer Resistance Protein (BCRP), a significant ABC transporter implicated in MDR, in lung and colon cancer cells directly impacted the ability of cancer …

C3 And C4 Grass Dominated Plant Communities Differ In Response To Future Larger And Less Frequent Rainfall, Zigeng Chen

Electronic Theses and Dissertations

Climate change is leading to larger and less frequent rainfall in the Northern Great Plains (NGP). We ask if this change in rainfall would influence carbon (C) and nitrogen (N) cycling in the NGP. First, we collected soils from C3 and C4 grass dominated plant communities from western South Dakota and conducted an incubation experiment to explore the effects of soil water content (SWC) and temperature on soil respiration (Rs) and N mineralization rate (ΔIN). Second, we conducted a three-year rainfallmanipulation (RaMP) experiment with two distinct rainfall regimes (frequent/small and infrequent/large events with constant total monthly precipitation) and two grasses …

Ecological Impacts Of Anthropogenic Chemicals On Non-Target Species And The Role Of Plant Diversity In Ecosystem Restoration And Resilience, Shiva Torabian

Electronic Theses and Dissertations

Understanding ecosystem processes in rangelands is of paramount importance for ensuring global food security, given their pivotal role in sustaining forage and livestock production. Central to this understanding are fundamental processes such as nutrient cycling, decomposition, and plant biomass dynamics. However, the use of anthropogenic chemicals in agricultural practices has the potential to exert significant influence on these critical ecosystem functions. A pivotal factor in this context is the plant diversity inherent to these rangeland ecosystems. Plant diversity not only provides essential ecosystem functions but also enhances them with the capacity to withstand and recover from perturbations. Ecosystems characterized by …

Effects Of Agricultural Chemicals On Native Plants Of The Northern Great Plains, Gabrielle Bolwerk

Electronic Theses and Dissertations

Agricultural chemicals are ubiquitous on the Northern Great Plains landscape and have negative impacts on non-target plant communities, even at small doses. Northern Great Plains grassland plant communities may experience herbicide drift from agricultural fields or be subject to livestock pharmaceuticals in grazing lands. My research objective was to evaluate if and how native plants are affected by agricultural chemical presence at different concentrations. In Chapter 2, I studied the effect of different concentrations of three common agricultural herbicides (2,4-D, atrazine, and trifluralin) on the germination, emergence, and growth of native plant species of the Northern Great Plains. I performed …

Biological Control Of Bacterial Leaf Streak Of Wheat Using Antagonistic Rhizobacteria, Ashley Frederickson

Electronic Theses and Dissertations

Wheat (Triticum aestivum L.) is one of the world’s most valuable crops, and the primary food grain produced in the United States. A major disease in wheat production is Bacterial Leaf Streak (BLS) caused by the gram-negative bacterium Xanthomonas translucens pv. undulosa (Xtu). Very few management strategies are available to growers to manage this disease, as common chemicals do not provide adequate control. A number of studies have been conducted on biological control using Rhizospheric bacteria for the control of various plant diseases, but limited data is available on the efficacy of biological control using Rhizospheric bacteria for controlling Bacterial …

Unveiling Race Diversity And Fungicide Sensitivity Profiles Of Pyrenophora Tritici Repentis Populations In South Dakota Collected From 2021-2023, Jaswinder Kaur

Electronic Theses and Dissertations

Tan spot, a foliar disease of wheat caused by the ascomycetes fungus Pyrenophora tritici repentis (Ptr), poses a significant threat to wheat crops globally. The disease gained economic importance in the late 1970s due to shifts in farming practices, such as minimal tillage and planting on crop residues, providing favorable conditions for the pathogen to overwinter and cause infections. Ptr is classified into eight races based on the production of necrotrophic effectors—Ptr ToxA (necrosis-inducing), Ptr ToxB, and Ptr ToxC (chlorosis-inducing on respective susceptible and sensitive cultivars)—resulting in distinct symptoms on susceptible wheat differentials. The inverse gene-for-gene hypothesis of Ptr suggests …

Writing Young Adult Fiction: Reflections On Narration And Theme In Young Adult Literature, Kimberly Davidson

Electronic Theses and Dissertations

According to Young Adult Library Services, “Young Adult Literature is a genre that is separate from Children's Literature. It emerged in the twentieth century when teenagers became a powerful force of the economy in the 1930s and gained prominence in the sixties.” Various sources list common elements that make YA literature a distinct category. 1) YA books appeal to the interests of readers from ages twelve to eighteen. 2) YA books typically explore a teenage character’s entry into an unfamiliar “world.” 3) YA books usually feature a protagonist’s self-reflection on events that influence their forays into the adult world. 4) …

Characterizing Vaginal Gene Expression In Prepubertal Gilts, Shannon Lee Dierking

Electronic Theses and Dissertations

The best-known predictor of reproductive success in gilts is the age at puberty. Early puberty (i.e., d170 – d180 of age) is associated with improved long-term reproductive performance and more full value offspring for market. The ability to predict, in the prepubertal stage, the age that a replacement gilt would be expected to achieve puberty has great reproductive and economic advantages. This work focuses on identifying biological markers that are potentially predictive of age at puberty. Study 1 identified changes in the vaginal epithelium during gilt reproductive development. Pre-pubertal gilts (n =13) were followed from d70 of age until first …

Electrochemical Innovations: Advancements In Lithium Metal Batteries & Supercapacitor For Energy Storage, Jyotshna Pokharel

Electronic Theses and Dissertations

Constructing an artificial solid electrolyte interphase (SEI) on lithium metal electrode is a promising approach to address the rampant growth of dangerous lithium morphologies (dendritic and dead Li0) and low Coulombic efficiency that plague development of lithium metal batteries. But it is not known how the Li+ transfer behavior in the SEI is coupled with mechanical properties. We demonstrate here a facile and scalable solution-processed approach to form a Li3N-rich SEI with a phase-pure crystalline structure that minimizes the diffusion energy barrier of Li+ across the SEI. Compared with a polycrystalline Li3N SEI obtained from conventional approaches, our phase-pure/single crystalline …

A Qualitative Study Of Library Staff’S Understanding Of Disability And Attitudinal Barriers In Libraries, Lisa A. Ferrara

Theses and Dissertations

This applied dissertation was designed to examine how library staff understand disability and attitudinal barriers, and to learn how they use this information when planning and implementing library programs and services. Individuals with disabilities are an underserved population in libraries. Although they could benefit from the programs and services that libraries have to offer, individuals with disabilities often experience barriers to participation that prevent them from using libraries. One area that has been understudied is that of the attitudinal barriers experienced by individuals with disabilities.

Participants were recruited through professional library associations throughout the United States using a screening questionnaire. …

Concluding Remarks By Conference Co-Organizer, Richard H. Weisberg

Articles

This Article represents the concluding remarks made by Professor Richard H. Weisberg at "Disarmed, Distracted, Disconnected & Distressed," a conference on Modern Legal Education and the Unmaking of American Lawyers, hosted by the University of Pittsburgh School of Law and the Law & Humanities Institute, April 20-April 23, 2023.

Paging Through Palimsests: Used Picture Books And Their Connection To Place, Danielle Ridolfi

Neureuther Book Collection Essay Competition

Graduate winner: 1st place, 2023, 36th Annual Carl Neureuther Student Book Collection Competition

Exploring The Land Of Fire And Ice: Iceland Through The Eyes Of A Newman Explorer, Ganesh Chelluboyina

Newman Exploration Travel Fund (NEXT) Awards

Ganesh Chelluboyina, PhD candidate in the Energy, Environmental, and Chemical Engineering Department at the McKelvey School of Engineering, explored the glaciers, wildlife, and fjords of Iceland, to see how they are changing amidst climate change.

The Conflict Among African American Penal Interests: Rethinking Racial Equity In Criminal Procedure, Trevor George Gardner

Scholarship@WashULaw

This Article argues that neither the criminal justice reform platform nor the penal abolition platform shows the ambition necessary to advance each of the primary African American interests in penal administration. It contends, first, that abolitionists have rightly called for a more robust conceptualization of racial equity in criminal procedure. Racial equity in criminal procedure should be considered in terms of both process at the level of the individual, and the number of criminal procedures at the level of the racial group—in terms of both the quality and “quantity” of stops, arrests, convictions, and the criminal sentencings that result in …

Lessons Learned In Prison, Daniel Keating

Scholarship@WashULaw

One way that I have tried to stay fresh as a teacher through the decades is to periodically force myself outside of my teaching comfort zone by trying something completely different. Sometimes these initiatives will end up being a one-time experiment. That was the case a little over ten years ago when I decided to teach a new course (Contracts) in a new format (online, but well before Zoom had become commonplace). Other times, my teaching experiment will prove to be more than just a frolic and detour, as was true eight years ago when I began offering a free …

Industry Groups In International Governance: A Framework For Reform, Melissa (M.J.) Durkee

Scholarship@WashULaw

The Sustainable Development Goals and the UN Guiding Principles on Business and Human Rights encourage engaging with businesses as partners in important global governance agendas. Indeed, many international organizations are now partnering with business groups to secure funding and private sector engagement. At the same time, reforms at the World Health Organization, Food and Agriculture Organization and others seek to restrain the dangers of mission distortion and capture by business groups. Shareholders at major multinational oil and gas companies also recognize these dangers and seek to rein in lobbying that is at odds with the goals of the Paris Climate …

After The Criminal Justice System, Benjamin Levin

Scholarship@WashULaw

Since the 1960s, the “criminal justice system” has operated as the common label for a vast web of actors and institutions. But, as critiques of mass incarceration have entered the mainstream, academics, activists, and advocates increasingly have stopped referring to the “criminal justice system.” Instead, they have opted for critical labels—the criminal legal system, the criminal punishment system, the prison industrial complex, etc. What does this re-labeling accomplish? Does this change in language matter to broader efforts at criminal justice reform or abolition? Or, does an emphasis on labels and language distract from substantive engagement with the injustices of contemporary …

Can Contract Emancipate? Contract Theory And The Law Of Work, Hanoch Dagan, Michael A. Heller

Faculty Scholarship

Contract and employment law have grown apart. Long ago, each side gave up on the other. In this Article, we re-unite them to the betterment of both. In brief, we demonstrate the emancipatory potential of contract for the law of work.

Today, the dominant contract theories assume a widget transaction between substantively equal parties. If this were an accurate description of what contract is, then contract law would be right to expel workers. Worker protections would indeed be better regulated by – and relegated to – employment and labor law. But contract law is not what contract theorists claim. Neither …

An Innovative State-Of-The-Art Health Storytelling Technique For Better Management Of Type 2 Diabetes, Sumbal Ali, Shumaila Bakht, Atta Ullah Jan, Iftikhar Alam, Ali Madi Almajwal, Tareq Osaili, Reyad Shakir Obaid, Moez Allslam Ezzat Faris, Leila Cheikh Ismail, Farah Najah, Hadia Radwan, Haydar Hasan, Mona Hashim, Sharifa Alblooshi, Bismillah Sehar, Falak Zeb

All Works

Background: Type 2 diabetes (T2D) is a chronic lifelong disease that requires long-term prevention and management strategies in a community setting. A health story is a novel technique that may be used as an effective tool for better prevention and management of T2D. Objective: The main objective of this study is to develop a story to be used as a social health technique based on contemporary scientific knowledge that may be used at a community level for better communication and management of T2D. Methods: A community–academic partnership was formed with a not-for-profit Nutrition Education, Awareness, and Training (NEAT) organization in …

Stochastic Tumor-Immune Interaction Model With External Treatments And Time Delays: An Optimal Control Problem, H. J. Alsakaji, F. A. Rihan, K. Udhayakumar, F. El Ktaibi

All Works

Herein, we discuss an optimal control problem (OC-P) of a stochastic delay differential model to describe the dynamics of tumor-immune interactions under stochastic white noises and external treatments. The required criteria for the existence of an ergodic stationary distribution and possible extinction of tumors are obtained through Lyapunov functional theory. A stochastic optimality system is developed to reduce tumor cells using some control variables. The study found that combining white noises and time delays greatly affected the dynamics of the tumor-immune interaction model. Based on numerical results, it can be shown which variables are optimal for controlling tumor growth and …

Resilience, Crisis Management And Continuous Improvement Against The Impact Of Covid-19 On Employees’ Engagement And Emotions. Insights From A Cypriot Sme, Christina Nizamidou

All Works

COVID-19 forced governments and organizations to navigate unchartered waters and shift to remote work to prevent its spreading, aiming to be resilient and maintain their sustainability. Recent research showed that COVID-19 impacted employees’ engagement and emotions. As every crisis is unique and every organization experiences a crisis differently, this study adopts the single-case study research method to understand better how a Cypriot SME in the financial service dealt with COVID-19 and its aftermath. By interviewing multiple employees from all hierarchical levels, it assesses the company’s level of resilience. Moreover, it demonstrates the company’s challenges to preserve its commitment to continuous …

Overhead Based Cluster Scheduling Of Mixed Criticality Systems On Multicore Platform, Amjad Ali, Asad Masood Khattak, Shahid Iqbal, Omar Alfandi, Bashir Hayat, Muhammad Hameed Siddiqi, Adil Khan

All Works

The cluster-based technique is gaining focus for scheduling tasks of mixed-criticality (MC) real-time multicore systems. In this technique, the cores of the MC system are distributed in groups known as clusters. When all cores are distributed in clusters, the tasks are partitioned into clusters, which are scheduled on the cores within each cluster using a global approach. In this study, a cluster-based technique is adopted for scheduling tasks of real-time mixed-criticality systems (MCS). The Decreasing Criticality Decreasing Utilization with the worst-fit (DCDU-WF) technique is used for partitioning of tasks to clusters, whereas a novel mixed-criticality cluster-based boundary fair (MC-Bfair) scheduling …

Explainable Machine Learning For Evapotranspiration Prediction, Bamory Koné, Rima Grati, Bassem Bouaziz, Khouloud Boukadi

All Works

No abstract provided.

Need For Affect, Problematic Social Media Use And The Mediating Role Of Fear Of Missing Out In European And Arab Samples, Areej Babiker, Mohamed Basel Almourad, Constantina Panourgia, Sameha Alshakhsi, Christian Montag, Raian Ali

All Works

Purpose: The growing awareness and concern about the excessive use of social media have led to an increasing number of studies investigating the underlying factors contributing to this behavior. In the literature, it is discussed that problematic social media use (PSMU) can impact individuals’ mental health and well-being. Drawing on the Interaction of Person-Affect-Cognition-Execution (I-PACE) model, this study aimed to examine the association between the need for affect (affect approach and affect avoidance) and PSMU (operationalized via the social media disorder scale), as well as the mediating role of fear of missing out (FoMO) in that relation. Participants and Methods: …

Flexible Global Aggregation And Dynamic Client Selection For Federated Learning In Internet Of Vehicles, Tariq Qayyum, Zouheir Trabelsi, Asadullah Tariq, Muhammad Ali, Kadhim Hayawi, Irfan Ud Din

All Works

Federated Learning (FL) enables collaborative and privacy-preserving training of machine learning models within the Internet of Vehicles (IoV) realm. While FL effectively tackles privacy concerns, it also imposes significant resource requirements. In traditional FL, trained models are transmitted to a central server for global aggregation, typically in the cloud. This approach often leads to network congestion and bandwidth limitations when numerous devices communicate with the same server. The need for Flexible Global Aggregation and Dynamic Client Selection in FL for the IoV arises from the inherent characteristics of IoV environments. These include diverse and distributed data sources, varying data quality, …

3d Indoor Modeling And Game Theory Based Navigation For Pre And Post Covid-19 Situation, Jaiteg Singh, Noopur Tyagi, Saravjeet Singh, Babar Shah, Farman Ali, Ahmad Ali Alzubi, Abdulrhman Alkhanifer

All Works

The COVID-19 pandemic has greatly affected human behavior, creating a need for individuals to be more cautious about health and safety protocols. People are becoming more aware of their surroundings and the importance of minimizing the risk of exposure to potential sources of infection. This shift in mindset is particularly important in indoor environments, especially hospitals, where there is a greater risk of virus transmission. The implementation of route planning in these areas, aimed at minimizing interaction and exposure, is crucial for positively influencing individual behavior. Accurate maps of buildings help provide location-based services, prepare for emergencies, and manage infrastructural …

Financial Technology In Egypt Between Opportunities And Challenges, Fady Tawakol

All Works

In Egypt, the Central Bank of Egypt is working to launch a new phase of financial technology, as one of the pillars of promotion of economic reform, and an effective and supportive mechanism for integrating the informal economy for individuals and institutions within the structure of the official economy of the state, and a way to Reality to raise and improve the standard of living and reduce poverty rates by containing certain segments of society from the marginalized, low-income and owners of small, medium and micro enterprises. The methodologies used explain the current state of financial inclusion and financial technology …

An Evaluation Of The Hr Function Within An Organisation And How The Function Contributes To Providing A Competitive Advantage., Larissa Drumond Lima

Business ETD Collections

Human resources management is all organizational activities concerned with recruiting, training, appraising and rewarding, directing, motivating, and controlling workers. And it can improve the workforce. This work discusses how the RH functions contribute to providing a competitive advantage. It starts with an essay about how the benefits of RH can lead to a competitive advantage. Then brings a recommendation regarding staff requirements and an organizational structure for the owner of Motorway Services.

Understanding Perceptions Of New-Onset Type 1 Diabetes Education In A Pediatric Tertiary Care Center, Gabriel Betancurvelez

Yale Medicine Thesis Digital Library

Background: Youth newly diagnosed with type 1 diabetes (T1D), and their families, require intensive education on the management of this chronic condition during this overwhelming period. Traditionally, our center conducts training in person during a hospital admission.

Methods: We studied family perceptions of our current patient education methods in an effort to elucidate strategies to augment education in the post-pandemic environment, where provider time in the room and visitation rules may limit face-to-face encounters.

Results: 25 families completed the survey (distributed to 156 in total, with approximately 21% response rate). The mean age at diagnosis was 9.52 ± 4.29 years …

The Association Between Social Needs Care Coordination And Social Needs Status Amongst Patients In A Federally Qualified Health Center, Autumn Nobles

Yale Medicine Thesis Digital Library

Social needs screenings within healthcare systems have grown more common with increasing discourse around the contribution of systemic determinants to health outcomes. These screenings have been used to describe the prevalence of social needs within communities but have not been evaluated for the impact that they and the interventions to which they are attached may have on health outcomes. Here we evaluate social needs screenings and their potential impact on patient health at a federally qualified health center in New Haven, Connecticut. We describe the baseline needs at the facility, evaluate change in reported social needs among patients undergoing screening, …