Digital Commons Network^™

Identification Of Conditions That Promote Biofilm Formation By Vibrio Fischeri And Elucidation Of The Underlying Signal Transduction Pathway, Courtney Noelle Dial

Dissertations

Biofilms are communities of microorganisms that have intrinsically antimicrobial properties and are difficult to treat in the clinical setting. The marine bacterium Vibrio fischeri efficiently colonizes its symbiotic squid host, Euprymna scolopes, by producing a transient biofilm dependent on the symbiosis polysaccharide (SYP), making it the perfect model system to study biofilm dynamics. In vitro, however, wild-type (WT) strain ES114 fails to form SYP – dependent biofilms. Instead, genetically engineered strains, such as those lacking the negative regulator BinK, have been developed to study SYP biofilms. Historically, V. fischeri has been grown using LBS, a complex medium containing tryptone and …

Simulation Psychological Safety Ecosystem: A Grounded Theory Study Of Nurses’ Experience With Psychological Safety In Prelicensure Simulation, Susan Eller

Dissertations

Over the past couple of decades, the utilization of simulation-based education in prelicensure nursing expanded in both frequency and functionality. Learning through simulation requires psychological safety where participants feel comfortable engaging to their fullest extent and can speak up or ask questions without fear of embarrassment to themselves or others. Professional simulation organizations provide recommendations for creating psychological safety, yet anecdotal stories from nurses report variability in their experiences ranging from positive to negative. Research regarding psychological safety in nursing education revealed some consistent themes of anxiety due to being observed or unfamiliar with simulation environments or expectations. The evolving …

An Examination Of Various Dimensions Associated With Nonprofit Board Member Diversity: The Significance Of Organizational Factors, Patrick Luke Decker-Tonnesen

Dissertations

This dissertation examined how leadership and organizational factors influence nonprofit board diversity. The goal of the research was to expand the data available in the social service sector associated with understanding the role of board member diversity within nonprofit organizations. Utilizing data from BoardSource’s Leading with Intent (2017) dataset, which included responses from 1,378 nonprofit Chief Executive Officers (CEOs), board racial, gender, and total diversity, along with several organizational factors, were included for descriptive and inferential analysis. Organizational factors included CEO racial and gender demographics, organization type, geographical location, revenue, personal contribution of board members, CEO perception of mission and …

Queer(Ly) Lingering In Nineteenth-Century British Literature, Emily Datskou

Dissertations

This dissertation is a critical critique of Queer Theory as an academic field. It argues that queer theory’s establishment as an academic discipline and as a periodizing and historicizing force through the bibliographies that make up its canon has upheld and supported the very normative models of temporality and progression that the field claims to resist. As a result, I argue, queer theory has focused most heavily on modernism and the twentieth and twenty-first centuries and has positioned the nineteenth century as the precursor to the queer strategies and representations that we see more fully fleshed out in the twentieth …

Dynamic Control Of The Cardiac Calcium Pump, Sean Robert Cleary

Dissertations

The sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) sequesters Ca2+ into the endoplasmic reticulum of cells to establish a reservoir for Ca2+ signaling. In the heart, the activity of this transporter is tightly controlled via direct interactions with two competing regulatory micropeptides: phospholamban (PLB) and dwarf open reading frame (DWORF). PLB inhibits SERCA, while DWORF activates SERCA. These competing interactions determine cardiac performance by modulating the Ca2+ signals that drive the contraction/relaxation cycle. Previous studies indicated these SERCA-micropeptide interactions are Ca2+-sensitive; SERCA binds PLB more avidly at low cytoplasmic [Ca2+] but binds DWORF better when [Ca2+] is high. Here, FRET-microscopy demonstrated that this …

Between Script And Scripture: Performance Criticism And Mark's Character(Ization) Of The Disciples, Zechariah Eberhart

Dissertations

This project reimagines a first-century reception of the Gospel of Mark within a historically reconstructed (yet hypothetical) performance event. In particular, it considers the disciples' character and characterization through the lens of performance criticism. Questions concerning the characterization of the disciples have been relatively one-sided in New Testament scholarship, in favor of their negative characterization. This project demonstrates why such assumptions need not be necessary when we (re-)consider the oral/aural milieu in which the Gospel of Mark was first composed and received by its earliest audiences. In this project, I demonstrate that despite its "relative" newness, the primary tenets of …

Design And Synthesis Of Novel Antibiotics And Anticancer Agents Targeting Pharmaceutically Relevant Enzymes, Sebastian Flieger

Dissertations

Boron neutron capture therapy (BNCT) is a binary radiotherapeutic modality for cancer treatment, in which delivery agents containing 10B atoms are transported into tumor cells and then irradiated with low-energy thermal neutrons. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are involved in the remodeling and degradation of all components of the extracellular matrix (ECM). Overexpressed levels of MMP activity have been implicated in several disease states including tumor growth and metastasis. We have appended a borane-rich carborane cluster onto MMP-targeting pharmacophores to enable delivery of 10B atoms to a tumor. Herein, we describe the molecular docking experiments …

Dungeons & Dragons & Dewey: Toward A Ludic Pedagogy Of Democratic Civic Life Through The Philosophy Of John Dewey And Tabletop Role-Playing Games, Susan Haarman

Dissertations

In this dissertation, which uses philosophical inquiry, I posit that tabletop role-playing games (RPGs) can provide an educative experience for democratic civic life in the Deweyan tradition. Tabletop RPGs present an invaluable resource for ongoing civic formation by encouraging deliberation and consensus building across shared goals and circumstances. Philosopher John Dewey emphasized that democracy is defined by the civic habits and collective action, not formal governance structures. The experience of playing tabletop RPGs can cultivate habitus and space for future and current citizens to practice democratic skills and commitments. Therefore, these games are a means that align with the ends …

Artapanus And Greek Colonial Poetics, Scott Harris

Dissertations

The fragments of Artapanus have proven to be enigmatic for most scholars over the years and as such have not been treated in significant detail. Most scholarship has been restricted to two separate lines of enquiry: genre and ethnicity. I suggest that the resonance between Greek colonial poetics sheds new light on Artapanus's literary agenda: namely, that Artapanus is constructing and representing the memory of Jewish cultural and political foundations using broader Greek poetics which were used to describe the civic, cultic and geographic foundation of a colony. In this way, Artapanus is no longer an outlier within the Hellenistic …

Comparative Analysis Of Classification Performance For U.S. College Enrollment Predictive Modeling Using Four Machine Learning Algorithms (Artificial Neural Network, Decision Tree, Support Vector Machine, Logistic Regression), Anna Kye

Dissertations

Every year, the national high school graduation rate is declining and impacting the number of students applying to colleges. Moreover, the majority of students are applying to more than one college. This makes a lot of colleges to be highly competitive in student recruitment for enrollment and thus, the necessity for institutions to anticipate uncertainties related to budgets expected from student enrollment has increased. Hence enrollment management has become a pivotal sector in higher education institutions. Data and analytics are now a crucial part of enhancing enrollment management. Through big data analytics-driven solutions, institutions expect to improve enrollment by identifying …

Key Stakeholders' Perceptions Of Stem Education In Zambia: A Mixed Methods Inquiry, Choobe M. Maambo

Dissertations

In the recent past, the concept of STEM education has become a “buzz phrase” in the Zambian education system, and yet, very little is known about STEM education let alone what those involved in STEM think or know about STEM in the country. The primary purpose of this study was to investigate key STEM stakeholders’ perceptions of STEM education in Zambia. To better understand STEM in the country, it was critical to explore the perceptions of STEM held by STEM teachers, STEM administrators, and STEM policymakers in the perception domains of STEM vision, STEM definition, STEM purpose, STEM relevance, and …

Past And Progress: Producing History At Chicago's 1933-34 World's Fair, Cate Liabraaten

Dissertations

During the country’s worst economic crisis, the Great Depression, Chicago hosted an event that presented a vision for the future. The 1933-34 Century of Progress Exposition was Chicago’s second world’s fair, important for revitalizing the local economy as well as encouraging optimism for a better future. While the fair’s theme officially focused on scientific and technological progress and was intended to be forward-looking, several exhibits dwelt on the past.

Study of these historic-themed exhibits reveals that by featuring Abraham Lincoln, Fort Dearborn, Jean Baptiste Point Du Sable, and a replica colonial village, Americans looked to their shared past to make …

None Of Us Are Safe: How Leaders Sustain Culturally Responsive Elementary And Middle School Improvement Planning, Jerry B. Michel

Dissertations

In the spring of 2020, school leaders, school boards, and teachers faced challenges beyond the COVID-19 pandemic in the United States, finding themselves under attack for the perceived applications of critical race theory in school curriculum. These conditions made active engagement in equity-focused school improvement planning more challenging. School leaders and leadership teams may benefit from using an established framework to identify strengths and areas for growth around culturally responsive pedagogy for effective school improvement planning. This article explores the use of Hammond’s (2015) Ready for Rigor Framework as a tool for identifying prioritizing which conditions for culturally responsive pedagogy …

Ethnic-Racial Socialization Practices Of Dominican Mothers With Their Young Children: Understanding Practices With A Sociohistorical Context Framework, Sabrina Altagracia Mendez-Escobar

Dissertations

Parents who self-identify as members of a community of color engage in practices aimed at teaching their children what it means to be a member of their ethnic-racial group which are called ethnic-racial socialization (ERS) practices. Promoting a positive sense of ethnic-racial identity through ERS contributes to balancing the negative effects of discrimination which can be helpful to children who are part of a marginalized group in the US including Latinx children. However, when the family practices of Latinx families are explored in the literature, various Latinx groups are lumped together. When studying ERS, research should aim to consider Latinx …

The Forgotten Minority—The Experiences Of Somali-Jareer Bantu Students In Higher Education: “I Don’T Even Exist At This Institution. I’M Barely Recognized As A Human Being”., Arli Mohamed

Dissertations

The purpose of this dissertation is to examine how students of Somali-Jareer Bantu descent experience education, particularly how they navigate higher education in the United States and how they make meaning of their experiences. Grounded in a descriptive phenomenological approach, the design method includes semi-structured individual and focus group interviews, with a holistic interpretative phenomenological analysis as a method of data analysis. This study utilizes descriptive phenomenology to investigate how Somali-Jareer Bantu students experience higher education in the U.S. and make meaning of their multiple identities as they navigate higher education environments. Using this methodological approach, the following questions guide …

Establishing A Health-Based Social Hierarchy, Akila Salaam Raoul

Dissertations

Social dominance theory (SDT) proposes a basic human nature to form social hierarchies based on social group membership with dominant and subordinate social groups. These social hierarchies are maintained through legitimizing myths, or beliefs that work to frame the existing social system as fair by suggesting that individuals receive the social status they deserve based on their actions and contributions to society as opposed to their group membership. The level at which an individual wants to maintain social hierarchies is indicated by their Social Dominance Orientation (SDO). SDT has been extensively studied in the context of race, gender, and age …

Higher Education, Neoliberalism, And Conflict: A Case Of The University Of Balochistan In Pakistan, Syed Amir Shah

Dissertations

The current study focuses on the role of peacebuilding in the higher education sector of Pakistan’s conflict-affected region of Balochistan. The research is an extended case study of the University of Balochistan. It addresses how the institution’s peacebuilding agency has evolved in the face of ethnic conflict and the neoliberal reforms pursued by the state during the past two decades. The research is based on the study of policy documents, official reports, and individual and focus group interviews with various educational actors.

The peacebuilding agency of the institution is theorized according to the 4Rs (Novelli et al., 2019; Novelli et …

Characterization Of Mroq-Dependent Regulation Of Staphylococcus Aureus Quorum Sensing, Madison Ruth Stock

Dissertations

Gram-positive bacteria produce small autoinducing peptides (AIPs), which act to regulate expression of genes that promote adaptive traits including virulence. The Gram-positive pathogen Staphylococcus aureus generates a cyclic AIP that controls expression of virulence factors via the accessory gene regulatory (Agr) system. S. aureus strains belong to one of four Agr groups (I, II, III, and IV), and each group harbors allelic variants of AgrD, the precursor of AIP. In a prior screen for S. aureus virulence factors, the Alonzo lab identified MroQ, a putative peptidase. A ΔmroQ mutant closely resembled a Δagr mutant and had significant defects in AIP …

Counter-Story In Machine Learning, Esperanza Huerta Espinosa

Faculty Learning Communities

No abstract provided.

Picturing Oneself In A Space, Nick Szydlowski

Faculty Learning Communities

No abstract provided.

Development Of Inattention And Executive Dysfunction In Youth With Spina Bifida: Condition Severity Variables As Predictors, Allison D. Payne

Master's Theses

Spina bifida (SB) is associated with neurologic impairments that increase individuals’ risk for neuropsychological deficits, particularly inattention and executive dysfunction. While extant literature has yet to examine the development of inattention in youth with SB, some research suggests that these youth may not experience the age-related improvements in executive dysfunction seen in the general population. SB is a heterogeneous condition; thus, it is important to consider variability in condition severity when examining outcomes over time in youth with SB. Lesion level and shunt status are commonly used as indicators of SB severity and have been significantly associated with variability in …

Soil Organic Matter Carbon Chemistry Signatures, Hydrophobicity And Humification Index Following Land Use Change In Temperate Peat Soils, Samuel Obeng Apori, Julie Dunne, Michelle Giltrap, Furong Tian

Articles

Peatlands play a critical role in the global carbon cycle, storing large amounts of carbon because of a net imbalance between primary production and the microbial decomposition of the organic matter. Nevertheless, peatlands have historically been drained for energy sources (e.g. peat briquettes), forestry, or agriculture - practices that could affect the quality of the soil organic matter (SOM) composition, hydrophobicity and humification index. This study compared the effect of land use change on the quality and composition of peatland organic material in Co-Offaly, Ireland. Specifically, drained and grazing peat (grassland), drained and forest plantation peat (forest plantation), drained and …

Table Of Contents

Journal of Business & Technology Law

No abstract provided.

Table Of Contents

Journal of Business & Technology Law

No abstract provided.

Recognizing Right: The Status Of Artificial Intelligence, Tanner W. Mathison

Journal of Business & Technology Law

No abstract provided.

Multistage Sustainability Education For University Engineering Students: A Case Study From Mechanical Engineering In Technological University Dublin, Kevin Delaney

Articles

Sustainability will be a key challenge that future engineering graduates must consider when solving problems. This paper sets out the approach taken in the mechanical engineering discipline of Technological University Dublin (TU Dublin) to help students acquire and develop the requisite skills to integrate aspects of sustainability when tackling engineering problems. The approach, which has already been implemented across a number of different design and innovation modules, consists of two distinct phases. In the first, students are educated about sustainability and related issues. In the second phase, students are educated for sustainability and are taught to identify, define and solve …

Cfd Simulation Of Anaerobic Granular Sludge Reactors: A Review, Camila D' Bastiani, David Kennedy, Anthony Reynolds

Articles

Anaerobic digestion processes can generate renewable energy in the form of biogas while treating organic wastewater. The generation of biogas within anaerobic digestion systems is directly linked to the mixing conditions inside the reactors. In high-rate reactors such as the up-flow anaerobic sludge blanket (UASB) reactor, the expanded granular sludge bed (EGSB) reactor and the internal circulation (IC) reactor, the hydrodynamic behaviour will depend on the interactions between the wastewater, the biogas, and the biomass granules. Over the past few years, various researchers have used computational fluid dynamics (CFD) to study the hydrodynamic behaviour in these types of reactors. This …

A Feed Direction Cutting Force Prediction Model And Analysis For Ceramic Matrix Composites C/Sic Based On Rotary Ultrasonic Profile Milling, M. Amin, M. F. Rathore, A. Ahmed, W. Saleem, Q. Li, A. Israr

Articles

Ceramic matrix composites have immense applications in the aerospace, aircraft, and automobile industries. Belonging to this class, carbon-fiber reinforced ceramic matrix composites (C/SiC) are used for critical applications due to their superior properties. However, these materials have also stringent properties of heterogeneity, anisotropy, and varying thermal properties that affect machining quality and process efficiency. So, developing a cutting force prediction model and analyzing machining parameters is an essential need for the accurate machining of such materials. In this study, a mechanistic-based feed direction cutting force prediction model for rotary ultrasonic profile milling of C/SiC composites is developed and validated experimentally. …

Takamiya Ms 23, Its Exemplar, And The Editio Princeps Of Piers Plowman, Ian Cornelius, J. Eric Ensley

English: Faculty Publications and Other Works

New Haven, Beinecke Library, MS Takamiya 23 is a mid sixteenth-century copy of the B Version of Piers Plowman, distinguished by pervasive linguistic modernization. The manuscript derives from a source very similar to that used by Robert Crowley for the editio princeps, a textual affiliation that remains unexplained. In their critical edition, George Kane and E. Talbot Donaldson collated Takamiya 23 in full but did not print its unique variant readings and the manuscript has not figured in recent textual scholarship on Piers Plowman. This neglect has led to some conclusions that should be revisited, particularly regarding …

Evolution Of Winning Solutions In The 2021 Low-Power Computer Vision Challenge, Xiao Hu, Ziteng Jiao, Ayden Kocher, Zhenyu Wu, Junjie Liu, James C. Davis, George K. Thiruvathukal, Yung-Hsiang Lu

Computer Science: Faculty Publications and Other Works

Mobile and embedded devices are becoming ubiquitous. Applications such as rescue with autonomous robots and event analysis on traffic cameras rely on devices with limited power supply and computational sources. Thus, the demand for efficient computer vision algorithms increases. Since 2015, we have organized the IEEE Low-Power Computer Vision Challenge to advance the state of the art in low-power computer vision. We describe the competition organizing details including the challenge design, the reference solution, the dataset, the referee system, and the evolution of the solutions from two winning teams. We examine the winning teams’ development patterns and design decisions, focusing …