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2023

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Magic! Missed Or Miracle?, Curt C. Anderson Jan 2023

Magic! Missed Or Miracle?, Curt C. Anderson

All ETDs from UAB

Truth default theory holds that people do not expect or notice deception unless they are triggered to think outside their natural tendency to believe others (Levine, 2020). It follows that people may not notice something deceptive or seemingly impossible if they are not first primed to raise suspicion. This study tests truth-default theory and triggering in the context of magic tricks. It hypothesized that people could watch two magic tricks performed without realizing they just witnessed something impossible because they were not primed to be aware of the presence of the possibility of deception. The research design is a three-group …

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The Impact Of Socioeconomic Status On Pain Severity And Functioning In A Pediatric Rheumatic Pain Population, Tolulope Adetayo Jan 2023

The Impact Of Socioeconomic Status On Pain Severity And Functioning In A Pediatric Rheumatic Pain Population, Tolulope Adetayo

All ETDs from UAB

Background: Low socioeconomic status (SES) may exacerbate pain and impede functioning in children with chronic widespread pain. SES can be categorized as objective or subjective and assessed at individual, family, and neighborhood levels. However, most studies do not assess SES this comprehensively, thus, the true impact of SES on child health is likely unknown. The proposed study examined the unique and interactive effects of different measures of SES on pain severity and functioning in children with rheumatic conditions including juvenile idiopathic arthritis (JIA), juvenile primary fibromyalgia syndrome (JPFS), and non-specific musculoskeletal pain (NSMP). Methods: 88 children (32 JIA, 31 JPFS, …

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The Effect Of Temperature On The Rate Of Antibiotic Resistance Development In Vibrio Vulnificus, Amber Marie Richardson Jan 2023

The Effect Of Temperature On The Rate Of Antibiotic Resistance Development In Vibrio Vulnificus, Amber Marie Richardson

All ETDs from UAB

Vibrio vulnificus is an environmentally encountered pathogen that humans may be exposed to through open wound contact with brackish waters or by ingestion of contaminated shellfish. In susceptible individuals, a V. vulnificus infection can spread rapidly, resulting in hospitalization, amputation, or even death. This bacterial species can cause aggressive infection, so treatment must often be aggressive as well. A typical treatment regimen includes combination therapy with a third-generation cephalosporin along with either a tetracycline or a fluoroquinolone. Although this method can work for now, antibiotic resistance is a looming threat that has emerged in many bacterial pathogens, including V. vulnificus. …

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Comparing Volumetric Wear Of Lithium Disilicate Against Different Ceramics And Enamel Antagonist An In-Vitro Study, Krisha Shah Jan 2023

Comparing Volumetric Wear Of Lithium Disilicate Against Different Ceramics And Enamel Antagonist An In-Vitro Study, Krisha Shah

All ETDs from UAB

Background: In patients with restored dentitions, it is possible for crowns on opposing teeth to gradually wear each other through chewing and bruxism. Therefore, the wear of restorative materials used for dental crowns is an important mechanical property for their long-term clinical success. Lithium disilicate is a widely used dental ceramic due to its strength, machinability, and translucency. Due to the rising use of ceramic restorations, a comparison of the wear resistance of lithium disilicate against different ceramic crown materials is useful for the clinician when selecting a crown material to oppose an existing lithium disilicate crown. Objective: To compare …

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Adaptive Behavior And Clinical Characteristics Of Children Referred For An Autism Spectrum Disorder Evaluation, Brianna Stein Jan 2023

Adaptive Behavior And Clinical Characteristics Of Children Referred For An Autism Spectrum Disorder Evaluation, Brianna Stein

All ETDs from UAB

The current study aimed to identify patterns of adaptive functioning in autistic children. Additionally, this study assessed predictors of adaptive functioning by examining whether cognitive ability predicted adaptive functioning in children with and without ASD and exploring whether expressive and receptive language predicted adaptive behavior and whether those relationships were moderated by an ASD diagnosis. Participants included 196 children who were evaluated for ASD at a tertiary care clinic. In this sample, 89 participants (45%) were diagnosed with ASD, 143 (73%) were male, and the average age was 6.63 years old (SD= 3.08). Profile analysis was used to evaluate the …

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Validation Of 'Bath Salts' Using Gas Chromatography-Mass Spectrometry, Andrew Harris Jan 2023

Validation Of 'Bath Salts' Using Gas Chromatography-Mass Spectrometry, Andrew Harris

All ETDs from UAB

New designer drugs are now being called “legal highs” because they were created to get around existing drug laws. This was done by modifying the molecular structures to create different chemical structures with similar effects to those illicit drugs. Synthetic cathinones, also referred to as ‘Bath Salts’, are the newest type of designer drugs that have stimulant effects. This research set out to validate a method for the separation and analysis of 3,4-Methylenedioxy Pyrovalerone 8 (3,4-Methylenedioxy PV8) 3,4-Methylenedioxy- N-Benzylcathinone (3,4-Methylenedioxy-N-BC), 4-Fluoro-alpha-Pyrrolidinohexanophenone (4-Fluoro-alpha-PHP), 4-Methyl-alpha-Ethylaminopentiophenone (4-Methyl-alpha- EAPP), and N-(1,4-dimethylpentyl)-3,4-Dimethoxyamphetamine (N-(1,4-dimethylpentyl)- 3,4-DMA). The parameters evaluated were limit of detection (LOD), interference, reproducibility, and …

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"Generous And Self-Devoted Being": Grief Psychology And Mary Shelley's Frankenstein, Madison Hogg Jan 2023

"Generous And Self-Devoted Being": Grief Psychology And Mary Shelley's Frankenstein, Madison Hogg

All ETDs from UAB

Scholarly discussion of the character Victor Frankenstein in Mary Shelley's Frankenstein generally determines his fatal flaw to be an overly ambitious nature, deter-mining a denouncement of ambition as the novel's core moral aim. However, Franken-stein's experience of and avoidance of grief shapes his actions. Exploring how modern understandings from the field of grief psychology reflect Shelley's description of Frankenstein's inner life and experiences, the novel can be treated as a metaphor for grief and grieving. A grief-informed reading of the novel brings many of the novel's main themes—connection versus isolation, belonging, and empathy—into sharper relief than ambition-focused readings, casting more …

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Use Of Atr-Ftir Spectroscopy For Estimating Postmortem Interval, Age Of Bloodstains, Sex Og Blood Donor, And Species Differentiation, Olivia Glaze Jan 2023

Use Of Atr-Ftir Spectroscopy For Estimating Postmortem Interval, Age Of Bloodstains, Sex Og Blood Donor, And Species Differentiation, Olivia Glaze

All ETDs from UAB

Blood is a powerful form of evidence that can provide valuable information about a crime. Most commonly blood is a source of DNA, however, generating a DNA profile can be costly, time consuming, and sometimes is not possible. Consequently, it is important to have methods for gathering additional information from blood evidence. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy is a method commonly used in confirmatory testing of drugs, fibers, paints, and other substances of forensic interest. This method only requires a small amount of sample, is non-destructive, sample preparation is minimal, and analysis is relatively fast. Recent research …

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A Colorblind Approach To Silencing African American Voices Through The Banning Of Critical Race Theory, Mia J. Freeman Jan 2023

A Colorblind Approach To Silencing African American Voices Through The Banning Of Critical Race Theory, Mia J. Freeman

All ETDs from UAB

This thesis focused on addressing the framing of criticisms of Toni Morrison's Beloved in the state of Virginia through the context of African American Criticism and Critical Race Theory. The methodology undertaken addresses the central research question, How might African American Criticism and Critical Race Theory provide a theoretical framework for responding to recent criticisms about Beloved? The researcher approached Beloved by historicizing select passages from the novel and situating those passages and the realities they reflect in the context of criticisms waged by parents and politicians. The thesis also explained how tenets of African American Criticism and Critical Race …

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Effect Of Different Supporting Die Materials And Crown Thicknesses On The Fracture Load Of Monolithic 3y-Tzp Zirconia And Lithium Disilicate Crowns, Akram Mohamed Mohamed Gad Sayed Ahmed Jan 2023

Effect Of Different Supporting Die Materials And Crown Thicknesses On The Fracture Load Of Monolithic 3y-Tzp Zirconia And Lithium Disilicate Crowns, Akram Mohamed Mohamed Gad Sayed Ahmed

All ETDs from UAB

Background: Conventionally, the strength of dental materials used for fixed restorations is measured using specimens of simplified geometry (i.e bars or discs). There is value in measuring the strength of these materials in their anatomic geometry (i.e crowns) under clinically relevant loading conditions. One advantage of performing the so-called crown fracture test is that the material may benefit from its ability to be strengthened by its bond to a tooth-mimicking die. When performing a crown fracture test, the ideal die material is natural tooth structure. However, the variability in natural tooth anatomy and microstructure makes the use of a standardized, …

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Systemic Review And Meta-Analysis Of Driving Impairments Associated With Autism Spectrum Disorder, Alecia Mercier Jan 2023

Systemic Review And Meta-Analysis Of Driving Impairments Associated With Autism Spectrum Disorder, Alecia Mercier

All ETDs from UAB

A developmental milestone that both contributes to and facilitates a successful transition into adulthood is the ability to drive. Despite the importance of driving on independence, only one in three autistic adolescents successfully obtain a driver’s license by age 21 compared to over three-fourths of non-autistic adolescents obtaining their licensure by 21 (Curry et al., 2018; Federal Highway Administration [FHA], 2020). The current study identified published findings related to autistic drivers and quantified the statistical significance of the conditions and driving contexts in which autistic drivers show the greatest risk for negative driving outcomes. A systematic search yielded 37 articles …

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Reframing The Study Of Peace Through The Lens Of Complex Adaptive Systems, Nick Mauro Jan 2023

Reframing The Study Of Peace Through The Lens Of Complex Adaptive Systems, Nick Mauro

All ETDs from UAB

Many researchers studying peace have posited that peace is a system. Although this approach has recently included steps to address complexity, current models have not sufficiently integrated their approach with complex adaptive systems to produce functionally dynamic models. Rather, current models describe peace systems as teleological and linear, which creates closed systems that do not incorporate feedback from the environment and, therefore, do not identify adaptive processes. Furthermore, these models reflect the state of a system, an arrangement of constituent parts in specific contexts, rather than capturing the complexity that is necessary for describing a dynamic system. To address these …

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Successful Aging Among Midlife Black Women: A Latent Class Analysis, Joshua Christian Julian Lewis Jan 2023

Successful Aging Among Midlife Black Women: A Latent Class Analysis, Joshua Christian Julian Lewis

All ETDs from UAB

Successful aging (SA), as outlined by Rowe and Khan, with its objective focus on disease and disability avoidance, maintaining high physical and cognitive function, and sustaining engagement in social and productive activities, was meant to be a benchmark for assessing health and aging. However, given its rigid criteria virtually no one “ages successfully” despite being in otherwise relatively good health. The assumption of unsuccessful aging in populations who experience a higher prevalence of chronic disease, illness, disability, and other health disparities, is implicit in the SA framework outlined by Rowe and Khan and would preclude many Black women from being …

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Automated Structural Health Monitoring Of Pavements Using Google Street View Images, Ebisidor Jeremiah Agberebi Jan 2023

Automated Structural Health Monitoring Of Pavements Using Google Street View Images, Ebisidor Jeremiah Agberebi

All ETDs from UAB

The Department of Transportation traditionally employed a structural health monitoring approach that involved training personnel to report the existing conditions of roadways. However, this approach is accompanied by huge costs that range from onboarding, vehicular equipment & maintenance cost, environmental costs from CO2 emission, safety costs, and the cost of errors made by personnel as each inspector would exercise his/ her discretion in analyzing the condition of the roadway. Therefore, it is necessary to adopt a more efficient and effective approach to SHM. The incorporation of google street view images [‘GSV’ a Google roadway street data repository, with high-resolution images], …

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Pieces Of Me, Lorice Tolbert Jan 2023

Pieces Of Me, Lorice Tolbert

All ETDs from UAB

Pieces of Me is a compilation of thoughts and memories in the form of micro-memoirs and short stories. Themes range from darker subject matters discussing abuse and grief to lighter topics such as hope and friendship. While each narrative may feature a different aspect, they are all parts of the same unique life experience. This work is about persevering, sometimes under strenuous circumstances, and finding your way to the other side.

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Family Members' Education And Cognitive Functioning Among Older Adults: Investigating The Mediating Role Of Health Behaviors, Lu Tian Jan 2023

Family Members' Education And Cognitive Functioning Among Older Adults: Investigating The Mediating Role Of Health Behaviors, Lu Tian

All ETDs from UAB

Despite a well-established relationship between education and cognitive performance in later life, few studies have considered the effects of educational attainment of the family. The education of one's parents can help prevent cognitive decline, as parents (G1) with more education can transfer more health knowledge, teach health literacy, and cultivate healthy lifestyles. This downward spillover between parental education (G1) and older adults’ (G2) cognitive health is well documented. For the downstream effect, attention is often given to maternal education rather than paternal education. Another line of research examined intergenerational transmissions from children (G3) to parents (G2), finding that having well-educated …

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Us Tv News' Portrayal Of The Types Of Bystander Intervention In Public Scenes Of Conflict And/Or Duress, Audrey Shreiner Jan 2023

Us Tv News' Portrayal Of The Types Of Bystander Intervention In Public Scenes Of Conflict And/Or Duress, Audrey Shreiner

All ETDs from UAB

This research aims to analyze the types of bystander intervention in public scenes of conflict and/ or duress as presented by United States (U.S.) broadcast media news sources, specifically television (TV). Stories of bystander intervention are regularly featured in news coverage of mass media. As a source of information and entertainment, media is a space of cultural (re)formation. Video analysis of real-life behavior, rather than lab constructs, expands the possibility of what can be observed of human behavior. This is what has expanded the understanding of the behavior of bystander intervention and has challenged the theory of the bystander effect. …

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Investigating The Reproductive Biology Of The Kemp's Ridley Sea Turtle And The Diamondback Terrapin: Implications For Conservation, Robby Joseph Brannum Jan 2023

Investigating The Reproductive Biology Of The Kemp's Ridley Sea Turtle And The Diamondback Terrapin: Implications For Conservation, Robby Joseph Brannum

All ETDs from UAB

The studies conducted within this thesis used physiological-based methodologies to assess the reproductive and developmental biology of two threatened turtle species. Chapter one investigates the decreased clutch frequency hypothesis as a potential cause for the recent loss in the 19% annual recovery rate in the Kemp’s ridley, Lepidochelys kempii. This study combined ultrasonography, testosterone analysis, and PIT tag assessment methods to re-evaluate the clutch frequency of Kemp’s ridleys nesting at the primary nesting beach of Rancho Nuevo. Results estimated a clutch frequency of 2.6 nests per female per season, suggesting that decreases in clutch frequency are not a potential factor …

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Uncovering The Role Of Spt5 In Rna Polymerase I Transcription Through Targeted Protein Degradation Via The Auxin Inducible Degron System In Saccharomyces Cerevisiae, Nathan Bellis Jan 2023

Uncovering The Role Of Spt5 In Rna Polymerase I Transcription Through Targeted Protein Degradation Via The Auxin Inducible Degron System In Saccharomyces Cerevisiae, Nathan Bellis

All ETDs from UAB

RNA Polymerases are the molecular machines responsible for the synthesis of RNA from the DNA template. The presence of these machines is an absolute requirement for the function and replication of all cellular organisms. In eukaryotic organisms, there are a minimum of three RNA polymerases (Pols I, II, II). Despite shared subunits and homology, these three protein complexes are functionally distinct, with many unique sub-units and additional trans-acting factors. Pol I is responsible for the synthesis of three of the four ribosomal RNA species which is the first and rate limiting step of ribosome biogenesis. Pol I synthesizes the majority …

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Characterizing A Unique Oprm1 Expressing Neuronal Population In The Rat Nucleus Accumbens, Emma Andraka Jan 2023

Characterizing A Unique Oprm1 Expressing Neuronal Population In The Rat Nucleus Accumbens, Emma Andraka

All ETDs from UAB

Opioid-related overdose deaths have increased drastically in the past three decades, and especially since the beginning of the COVID-19 pandemic, due to the addictive, analgesic, and euphoric properties of the drugs. To produce these effects, opioids bind to the mu opioid receptor (MOR) in GABAergic neurons. The MOR is encoded by the Oprm1 gene and is expressed in multiple brain regions that regulate reward and motivation, such as the nucleus accumbens (NAc). Previous studies of Oprm1 knockdown in medium spiny neurons (MSNs) of the mouse NAc have shown that these neuronal populations are involved in reinforcing reward-context pairing as well …

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Short Root Anomaly: Prevalence, Genetics, And Its Effect In Orthodontic Treatment, Lauren Sharp Jan 2023

Short Root Anomaly: Prevalence, Genetics, And Its Effect In Orthodontic Treatment, Lauren Sharp

All ETDs from UAB

Short root anomaly (SRA) is a poorly understood developmental defect of root formation. Patients with this condition have short roots with rounded apexes and significantly reduced root to crown (R/C) ratios1, which can compromise dental care and may increase the risk of root resorption during tooth movement. SRA prevalence ranges from 1-10% but has not been studied in many ethnic populations. Furthermore, its genetic basis is undetermined. Our goals were to determine the prevalence of SRA among various ethnicities, identify genetic variations contributing to its phenotype, and evaluate how SRA can affect the outcome of orthodontic treatment. This study found …

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Nasal Septum Deviation In Patients With Or Without Impacted Canines, Naurine Shah Jan 2023

Nasal Septum Deviation In Patients With Or Without Impacted Canines, Naurine Shah

All ETDs from UAB

There has been a recent rise in interest for studying the relationship between orthodontic treatment and the airway. Most studies have focused on measuring the oropharyngeal airway and how it is affected by growth with or without orthodontic treatment. The Nasal Septum, a midline structure is an integral part of the anatomy of the nasopharynx. Nasal Septum Deviations (NSD) can be caused by mechanical injuries, nasal polyps, neoplasia, infections, genetic influences as well as congenital malformations. The proximity of the septum can be correlated to changes in the housing of dentition in the naso maxillary complex. Objective: We aim to …

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Hepatotoxic Effect Of Cadmium And Available Therapeutic Options, Tomilola Olaolu, Favour Jibulu, Rotimi Damilare Jan 2023

Hepatotoxic Effect Of Cadmium And Available Therapeutic Options, Tomilola Olaolu, Favour Jibulu, Rotimi Damilare

The Thai Journal of Pharmaceutical Sciences

Hepatoxicity, also known as toxic hepatitis, is a condition, in which the liver becomes inflamed due to exposure to such substances as chemicals, medications, herbal products, or excessive alcohol consumption. Cadmium is a major environmental pollutant from agricultural and industrial sources and has been reported to induce hepatotoxicity. Cadmium can also be found in phosphate fertilizers, detergents, and refined petroleum products as an impurity and used industrially in the production of polyvinyl chloride product stabilizers and the fabrication of nickel-cadmium batteries. Cadmium can be absorbed into the human body through the gastrointestinal tract, respiratory, and dermal routes. Cadmium-induced hepatic damage …

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Neuroprotective Effect Of Isolated Palmatine From Tinospora Cordifolia (Thunb.) Miers Leaves In Aluminium Chloride Induced Oxidative Stress, Kuntal Das, B. Ratna, S. V. Rajendra Jan 2023

Neuroprotective Effect Of Isolated Palmatine From Tinospora Cordifolia (Thunb.) Miers Leaves In Aluminium Chloride Induced Oxidative Stress, Kuntal Das, B. Ratna, S. V. Rajendra

The Thai Journal of Pharmaceutical Sciences

The present study aimed at determining the neuroprotective role of palmatine isolated from Tinospora cordifolia (TC) leaves on neurobehavioral parameters in aluminium chloride induced oxidative stress and to assess the biochemical and histopathological alterations brought about by the same on mouse brain. Isolated Palmatine showed antioxidant potential confirmed with DPPH assay. The purity of the isolated palmatine was confirmed with FTIR, C-13 NMR and mass spectroscopy. Four groups of animals with doses of 10 and 20mg/kg respectively were studied against aluminium chloride induced oxidative stress (100mg/kg) for the alterations it brought in neurobehavioral parameters using actophotometer, rotarod test, Morris water …

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Risk Assessment Of Gmp Inspection Of Overseas Pharmaceutical Manufacturers Based On Desktop Inspection As Required In Thailand, Varin Titapiwatanakun, Waranon Cheewajorn, Narueporn Sutanthavibul Jan 2023

Risk Assessment Of Gmp Inspection Of Overseas Pharmaceutical Manufacturers Based On Desktop Inspection As Required In Thailand, Varin Titapiwatanakun, Waranon Cheewajorn, Narueporn Sutanthavibul

The Thai Journal of Pharmaceutical Sciences

Good manufacturing practice (GMP) inspection of overseas manufacturers in Thailand is regulated under desktop inspection that is verified mainly by documents. Thus the inspection results may cause certain gaps in terms of quality and reliability, particularly when compared with on-site inspection. This work utilized the pharmaceutical quality risk management in the International Council for Harmonization Q9 guideline with Failure Mode and Effects Analysis (FMEA) tool to study and manage potential risks. The study design consisted of five steps. First, a pre-assessment step was to set up a team to consider a data analysis of the inspection data and drug quality …

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Analysis Of Phytochemical Potential And Investigation Of Hypoglycemic Effect Of Cassia Fistula L. Fruit Wall Extracts By Alpha-Amylase Assay And Streptozotocin Induced Diabetic Rat Model., Samreen Tanveer, Athar Masood, Seemab Ali, Afshan Arshad Jan 2023

Analysis Of Phytochemical Potential And Investigation Of Hypoglycemic Effect Of Cassia Fistula L. Fruit Wall Extracts By Alpha-Amylase Assay And Streptozotocin Induced Diabetic Rat Model., Samreen Tanveer, Athar Masood, Seemab Ali, Afshan Arshad

The Thai Journal of Pharmaceutical Sciences

This study will estimate the proximate composition of phytochemicals and study the hypoglycemic effect of Cassia fistula Linn fruit wall extracts. Materials and methods: The in vitro inhibition of alpha-amylase and in vivo streptozotocin induce diabetes model was applied to investigate the anti-diabetic activity. For standardization, Atomic Absorption Spectroscopy and FTIR were used. Results: Proximate analysis values were found to be within the specific limits as recommended by the British Pharmacopeia. The FTIR spectrum and elemental analysis confirmed occurrence of various functional groups and minerals. The phytochemical analysis indicates the higher fraction of the carbohydrates (69.89%) and relatively lesser proportion …

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Development Of Amino Acid Salt-Based Curcumin@Lysine Acetate Co-Amorphous System Using Liquid-Assisted Grinding For Improved Solubility And Dissolution, Udaykumar Patil, Snehal Rawal, Jidnyasa Pantwalawalkar, Sopan Nangare, Dilip Dagade, Pravin Patil, Namdeo R. Jadhav Jan 2023

Development Of Amino Acid Salt-Based Curcumin@Lysine Acetate Co-Amorphous System Using Liquid-Assisted Grinding For Improved Solubility And Dissolution, Udaykumar Patil, Snehal Rawal, Jidnyasa Pantwalawalkar, Sopan Nangare, Dilip Dagade, Pravin Patil, Namdeo R. Jadhav

The Thai Journal of Pharmaceutical Sciences

Curcumin, multivalued phytoceutical, exhibits appreciable safety. However, its therapeutic utility is significantly compromised due to low aqueous solubility, and thus, poor absorption and low bioavailability become apparent. To surpass this limitation, the present work aims to develop amino acid salt-based curcumin@lysine acetate co-amorphous system for improved solubility and dissolution. Initially, screening of curcumin-amino acid mixtures was performed for saturation solubility assessment. Considering the outcome, lysine acetate was formulated to generate a co-amorphous mixture (COAM) by liquid-assisted grinding and evaluated for saturation solubility and different spectroscopical characterizations. Curcumin-lysine acetate COAM tablet formulation was developed by direct compression method and evaluated for …

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Solubility Enhancement Of Diacerein By Spray Drying Technique, Formulation Development, And In Vivo Study, Devidas G. Bachhav, Somashekhar S. Khadabadi, Leena P. Deore, Vilas B. Ghavate Jan 2023

Solubility Enhancement Of Diacerein By Spray Drying Technique, Formulation Development, And In Vivo Study, Devidas G. Bachhav, Somashekhar S. Khadabadi, Leena P. Deore, Vilas B. Ghavate

The Thai Journal of Pharmaceutical Sciences

Purpose: The aim of the present research was solubility and dissolution rate enhancement of diacerein by spray drying technique. Materials and Methods: Solid dispersions of diacerein with PEG-600, guar gum, poloxamer-188 and aerosil were prepared in different ratios using 32 factorial designs. FTIR, DSC, XRD and SEM were performed to study the interaction between drug and polymers and evaluated for in-vitro drug release study. Results and Discussion:In spray dried solid dispersion formulations there was decrease in crystallinity of diacerein, which leads to increase in dissolution of diacerein from solid dispersions. Diacerein 50 mg immediate release tablets formulated (using spray dried …

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Determination Of Anti-Herpes Simplex Virus Type 1 Activity Of The Air Filter Coated With Silver Ions Using A Modified Method Of Iso 21702:2019, Mali Wirotesangthong, Ariya Khanboon, Kanyanat Piewpong Jan 2023

Determination Of Anti-Herpes Simplex Virus Type 1 Activity Of The Air Filter Coated With Silver Ions Using A Modified Method Of Iso 21702:2019, Mali Wirotesangthong, Ariya Khanboon, Kanyanat Piewpong

The Thai Journal of Pharmaceutical Sciences

Background: Since severe acute respiratory syndrome coronavirus 2 causing coronavirus disease 2019 pandemic has emerged, various air membrane filters with antimicrobial agents have been explored and investigated for inactivating virus particles. Objectives: The purpose of this study was to determine an antiviral activity of the air filter coated with silver ions using the method of ISO 21702:2019. Materials and Methods: Herpes simplex virus type 1 (HSV-1), KOS strain, an enveloped virus causing skin, mucous membrane, and respiratory tract infection (RTI) were tested with the non-porous surface coated with or without silver ions (control filter) for 0, 24 h at 25°C. …

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Pyrazole-Oxime As Reactivator For Chlorpyrifos Inhibited Acetylcholinesterase: Synthesis And In Vitro Reactivation Study, Manjunatha Katagi, Jennifer Fernandes, Girish Bolakatti, B. P. Nandeshwarappa, M. L. Sujatha, D. K. Ramesh, Shivlingrao Mamledesai Jan 2023

Pyrazole-Oxime As Reactivator For Chlorpyrifos Inhibited Acetylcholinesterase: Synthesis And In Vitro Reactivation Study, Manjunatha Katagi, Jennifer Fernandes, Girish Bolakatti, B. P. Nandeshwarappa, M. L. Sujatha, D. K. Ramesh, Shivlingrao Mamledesai

The Thai Journal of Pharmaceutical Sciences

The present communication focused on synthesis, characterization and in vitro reactivation of chlorpyrifos inhibited acetylcholinesterase by pyrazole-oxime derivatives. A series of (E)-1-(phenyl)-3-(4-(dimethylamino)phenyl)prop-2-en-1-ones (1a-e) were synthesized from substituted acetophenone and aldehydes by adopting standard procedure. The intermediates 1-(5-(Phenyl)-3-(4-(dimethylamino)phenyl)-4,5-dihydropyrazol-1-yl)ethanones (2a-e) were synthesized by treating 1a-e with hydrazine hydrate in glacial acetic acid under the reflux. The title compounds (3a-e) were prepared by the condensation of (2a-e) with hydroxylamine hydrochloride in ethanol and pyridine as a base. The structures of all the newly synthesized products were confirmed by physicochemical and spectral analysis. All the synthesized compounds (3a-e) were screened for their intoxification of …

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