Digital Commons Network^™

Criminology And Violent Extremist Radicalization, Starlett Michele Martin

Walden Dissertations and Doctoral Studies

After the 9/11 terrorist attacks, research on foreign terrorism became extensive in the United States while research on domestic terrorism and violent extremist radicalization was lacking. Despite the research that has been done, there was a lapse in scholarship analyzing terrorism radicalization and its relationship with criminology. The purpose of this general qualitative study was to analyze the perceptions of experts in terrorism and criminology about how factors of criminology can explain violent extremist radicalization. This study used two conceptual models of terrorism radicalization: (a) the staircase to terrorism and the (b) 4-stage model of the terrorist mindset. In addition, …

Emotional Intelligence Among Nigerian Construction Project Leaders During Periods Of Uncertainty, Ibrahim Hassan Mashi

Walden Dissertations and Doctoral Studies

Some construction project leaders in Nigeria have exhibited leadership ineffectiveness during periods of uncertainty due to a lack of emotional intelligence (EI) engagement. This has led to poor performance of construction projects in Nigeria. The purpose of this qualitative exploratory case study was to explore the engagement of EI in enhancing leadership effectiveness among construction project leaders in Nigeria during periods of uncertainty. Fifteen participants involving construction project leaders were selected through purposeful sampling from five construction firms in Abuja, Nigeria. The target participants were specifically chosen for their expertise and experience to ensure that the information created is relevant …

Locus Of Control, Mindfulness, And Perceived Caregiver Burden In Informal Caregivers Of People With Dementia, Tiffany Marinos-Sterge

Walden Dissertations and Doctoral Studies

AbstractAdult informal caregivers play an essential role in the care of people with dementia living in the community. Adult informal caregivers may experience a host of negative psychological, emotional, and physical effects because of their roles as caregivers. The purpose of this quantitative correlational study was to investigate the influence of locus of control and mindfulness on the perceived caregiver burden experienced by adult informal caregivers of people with dementia, controlling for relevant sociodemographic characteristics. Social determination theory and social learning theory provided the theoretical foundation for this study. Variables were measured using the Caregiver Burden Inventory, Mindfulness Attention Awareness …

Quantifying The Implementation And Cost Of A Multisite Antibiotic Stewardship Intervention For Asymptomatic Bacteriuria, Eva Amenta, Larissa Grigoryan, Suja S Rajan, David Ramsey, Jennifer R Kramer, Annette Walder, Andrew Chou, John N Van, Sarah L Krein, Sylvia Hysong, Aanand D Naik, Barbara W Trautner

Faculty, Staff and Student Publications

OBJECTIVE: The intensity of an antibiotic stewardship intervention to achieve clinical impact is not known. We conducted a multisite dissemination project of an intervention to reduce treatment of asymptomatic bacteriuria (ASB) and studied: (1) the association between implementation metrics and clinical outcomes and (2) the cost of implementation.

DESIGN/SETTING/PARTICIPANTS: A central site facilitated a multimodality intervention to decrease unnecessary urine cultures and antibiotic treatment in patients with ASB at 4 Veterans Affairs medical centers.

METHODS: The intervention consisted of a decision support aid algorithm and interactive teaching cases that provided in the moment audit and feedback on how to manage …

Wastewater Pandemic Preparedness: Toward An End-To-End Pathogen Monitoring Program, Justin R Clark, Austen Terwilliger, Vasanthi Avadhanula, Michael Tisza, Juwan Cormier, Sara Javornik-Cregeen, Matthew Clayton Ross, Kristi Louise Hoffman, Catherine Troisi, Blake Hanson, Joseph Petrosino, John Balliew, Pedro A Piedra, Janelle Rios, Jennifer Deegan, Cici Bauer, Fuqing Wu, Kristina D Mena, Eric Boerwinkle, Anthony W Maresso

Faculty, Staff and Student Publications

Molecular analysis of public wastewater has great potential as a harbinger for community health and health threats. Long-used to monitor the presence of enteric viruses, in particular polio, recent successes of wastewater as a reliable lead indicator for trends in SARS-CoV-2 levels and hospital admissions has generated optimism and emerging evidence that similar science can be applied to other pathogens of pandemic potential (PPPs), especially respiratory viruses and their variants of concern (VOC). However, there are substantial challenges associated with implementation of this ideal, namely that multiple and distinct fields of inquiry must be bridged and coordinated. These include engineering, …

Tnik Regulation Of Interferon Signaling And Endothelial Cell Response To Virus Infection, Khanh M Chau, Abishai Dominic, Eleanor L Davis, Sivareddy Kotla, Estefani Turcios Berrios, Arsany Fahim, Ashwin Arunesh, Shengyu Li, Dongyu Zhao, Kaifu Chen, Alan R Davis, Minh T H Nguyen, Yongxing Wang, Scott E Evans, Guangyu Wang, John P Cooke, Jun-Ichi Abe, David P Huston, Nhat-Tu Le

Faculty, Staff and Student Publications

BACKGROUND: Traf2 and Nck-interacting kinase (TNIK) is known for its regulatory role in various processes within cancer cells. However, its role within endothelial cells (ECs) has remained relatively unexplored.

METHODS: Leveraging RNA-seq data and Ingenuity Pathway Analysis (IPA), we probed the potential impact of TNIK depletion on ECs.

RESULTS: Examination of RNA-seq data uncovered more than 450 Differentially Expressed Genes (DEGs) in TNIK-depleted ECs, displaying a fold change exceeding 2 with a false discovery rate (FDR) below 0.05. IPA analysis unveiled that TNIK depletion leads to the inhibition of the interferon (IFN) pathway [-log (

SUMMARY: Our findings suggest that …

Development Of Competency-Based Online Genomic Medicine Training (Cogent), Susanne B Haga, Wendy K Chung, Luis A Cubano, Timothy B Curry, Philip E Empey, Geoffrey S Ginsburg, Kara Mangold, Christina Y Miyake, Siddharth K Prakash, Laura B Ramsey, Robb Rowley, Carolyn R Rohrer Vitek, Todd C Skaar, Julia Wynn, Teri A Manolio

Faculty, Staff and Student Publications

The fields of genetics and genomics have greatly expanded across medicine through the development of new technologies that have revealed genetic contributions to a wide array of traits and diseases. Thus, the development of widely available educational resources for all healthcare providers is essential to ensure the timely and appropriate utilization of genetics and genomics patient care. In 2020, the National Human Genome Research Institute released a call for new proposals to develop accessible, sustainable online education for health providers. This paper describes the efforts of the six teams awarded to reach the goal of providing genetic and genomic training …

Dietary Behaviours During Covid-19 Among Households At Risk For Food Insecurity, Maha Almohamad, Allison Marshall, Jayna Markand Dave, Ru-Jye Chuang, Christine Markham, Shreela Sharma

Faculty, Staff and Student Publications

The objective of the present study was to examine associations between variables of COVID-19-related concerns and changes in fruit and vegetable (FV) consumption among a sample of participants from the Brighter Bites program at risk for food insecurity. Cross-sectional data were collected during April-June 2020 using a rapid-response survey to understand social needs, COVID-19-related concerns and diet-related behaviours among families with children participating in Brighter Bites (

Community-Based Tuberculosis Contact Management: Caregiver Experience And Factors Promoting Adherence To Preventive Therapy, Micaela Sandoval, Godwin Mtetwa, Tara Devezin, Debrah Vambe, Joyce Sibanda, Gloria S Dube, Thandeka Dlamini-Simelane, Bhekumusa Lukhele, Anna M Mandalakas, Alexander Kay

Faculty, Staff and Student Publications

Delivery of tuberculosis preventive therapy (TPT) for children with household exposure to tuberculosis is a globally supported intervention to reduce the impact of tuberculosis disease (TB) in vulnerable children; however, it is sub-optimally implemented in most high-burden settings. As part of a community-based household contact management program, we evaluated predictors of adherence to community based TPT in children and performed qualitative assessments of caregiver experiences. The Vikela Ekhaya (Protect the Home) project was a community-based household contact management program implemented between 2019 and 2020 in the Hhohho Region of Eswatini. At home visits, contact management teams screened children for TB, …

Early Detection Of Mandible Osteoradionecrosis Risk In A High Comorbidity Veteran Population, David Chamberlayne Wilde, Sagar Kansara, Logan Banner, Rickey Morlen, David Hernandez, Andrew Tsao Huang, Weiyuan Mai, Clifton David Fuller, Stephen Lai, Vlad Constantin Sandulache

Faculty, Staff and Student Publications

OBJECTIVE: Osteoradionecrosis (ORN) of the mandible is a devastating complication of external beam radiation therapy (EBRT) for head and neck squamous cell carcinoma (HNSCC). We sought to ascertain ORN risk in a Veteran HNSCC population treatment with definitive or adjuvant EBRT and followed prospectively.

STUDY DESIGN: Retrospective analysis of prospective cohort.

SETTING: Tertiary care Veterans Health Administration (VHA) medical center.

METHODS: Patients with HNSCC who initiated treatment at the Michael E. DeBakey Veterans Affairs Medical Center (MEDVAMC) are prospectively tracked for quality of care purposes through the end of the cancer surveillance period (5 years post treatment completion). We retrospectively …

Non-Alcoholic Fatty Liver Disease And Metabolic Syndrome: The Role Of Gender Differences And Menopausal Status Of Women, Kimberly Kushner

Walden Dissertations and Doctoral Studies

There are few studies that investigate the association between non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) predominantly in menopausal women. This quantitative study investigated the association between MetS and NAFLD while controlling for age, gender, ethnicity, and menopausal status of women. The theoretical framework that helps establish and guide the research was the diffusion of innovation (DOI). A multivariable logistic regression was conducted using secondary data from the National Health and Nutrition Examination Survey. There is a statistically significant association between MetS, and NAFLD after controlling for age (OR = 2.96, 95% CI = 2.319–3.778, p < 0.001). However, ethnicity was not statistically significant. After further controlling for gender, the relationship remained statistically significant and exhibited a decrease in risk for females compared to males (OR = -.734, 95%CI = .387–.596, p < 0.001). Lastly, focusing on women only, and further controlling for menopausal status, the association between MetS and NAFLD was still statistically significant (OR = 2.227, p < 0.001). Mexican Americans, other Hispanics, and Non-Hispanic Black women were at higher risk (95% CI 1.102–7.039, 1.321–5.351, and 1.255–3.013, respectively). Implications for positive social change include adopting proactive and preventative strategies that can improve the quality of life for vulnerable patients and reduce morbidity and mortality associated with MetS and NAFLD.

Employee Retention Strategies In Selected Small And Medium Enterprises In Nigeria, Ijeoma Omeoga

Walden Dissertations and Doctoral Studies

AbstractThe lack of employee retention strategies in Nigeria’s small and medium enterprises (SMEs) can have adverse business outcomes. Business leaders are concerned about employee retention strategies since they can help reduce turnover and retain experienced employees. Grounded in Herzberg’s two-factor theory of motivation, the purpose of this qualitative multiple-case study was to explore strategies business leaders use to retain their experienced employees. The participants were four business leaders of four SMEs in Nigeria who successfully implemented strategies that helped retain their experienced employees. Data were collected using semistructured interviews and a review of organization policy documents. Through thematic analysis, four …

Visual Literacy: A Critical Literacy Competency In 21st Century Higher Education, Elizabeth Bucciarelli

Faculty Scholarship 2023

No abstract provided.

When Pro(?)-Football Came To Ypsilanti, Steven J. Ramold

Faculty Scholarship 2023

No abstract provided.

Uneven Impact Of The Reading Street Common Core Program On Student Reading Achievement, Donna Lee West

Walden Dissertations and Doctoral Studies

AbstractIn 2013, a school district located in the northeastern region of the US implemented the Reading Street Common Core Program (RS), a highly structured and scripted reading program. The problem was that the program had an uneven effect on elementary level student reading achievement at Title 1 schools in the district. This qualitative case study explored how teachers, professional development lead teachers (PDLTs), and principals at four high performing schools (HPS) and four low performing schools (LPS) experienced implementation of the RS, and how their experiences explained the uneven effect on student reading achievement. The conceptual framework that grounded the …

Strategies Aircraft Manufacturing Organizational Leaders Use For Proper Material Pricing, Chin Kuei Jen

Walden Dissertations and Doctoral Studies

The lack of proper material pricing strategies can challenge manufacturers’ profitability and growth. Aircraft manufacturing leaders are concerned because understanding and developing material pricing strategies are essential to increasing profitability. Grounded in price theory, the purpose of this qualitative single case study was to explore strategies aircraft manufacturing organizational leaders use for proper material pricing estimates. The participants were four aircraft manufacturing organizational leaders from a successful aircraft manufacturing business located in the state of Georgia. Data were gathered from semistructured interviews and document reviews and analyzed using Yin’s five step approach. The four themes that emerged were the impact …

Mitigating Anomalous Electricity Consumption In Smart Cities Using An Ai-Based Stacked-Generalization Technique, Arshid Ali, Laiq Khan, Nadeem Javaid, Safdar Hussain Bouk, Abdulaziz Aldegheishem, Nabil Alrahjeh

Computer Science Faculty Publications

Energy management and efficient asset utilization play an important role in the economic development of a country. The electricity produced at the power station faces two types of losses from the generation point to the end user. These losses are technical losses (TL) and non-technical losses (NTL). TLs occurs due to the use of inefficient equipment. While NTLs occur due to the anomalous consumption of electricity by the customers, which happens in many ways; energy theft being one of them. Energy theft majorly happens to cut down on the electricity bills. These losses in the smart grid (SG) are the …

Claimdistiller: Scientific Claim Extraction With Supervised Contrastive Learning, Xin Wei, Md Reshad Ul Hoque, Jian Wu, Jiang Li

Computer Science Faculty Publications

The growth of scientific papers in the past decades calls for effective claim extraction tools to automatically and accurately locate key claims from unstructured text. Such claims will benefit content-wise aggregated exploration of scientific knowledge beyond the metadata level. One challenge of building such a model is how to effectively use limited labeled training data. In this paper, we compared transfer learning and contrastive learning frameworks in terms of performance, time and training data size. We found contrastive learning has better performance at a lower cost of data across all models. Our contrastive-learning-based model ClaimDistiller has the highest performance, boosting …

An Approach To Developing Benchmark Datasets For Protein Secondary Structure Segmentation From Cryo-Em Density Maps, Thu Nguyen, Yongcheng Mu, Jiangwen Sun, Jing He

Computer Science Faculty Publications

More and more deep learning approaches have been proposed to segment secondary structures from cryo-electron density maps at medium resolution range (5--10Å). Although the deep learning approaches show great potential, only a few small experimental data sets have been used to test the approaches. There is limited understanding about potential factors, in data, that affect the performance of segmentation. We propose an approach to generate data sets with desired specifications in three potential factors - the protein sequence identity, structural contents, and data quality. The approach was implemented and has generated a test set and various training sets to study …

Progenitor Cell Isolation From Mouse Epididymal Adipose Tissue And Sequencing Library Construction, Qianglin Liu, Chaoyang Li, Yuxia Li, Leshan Wang, Xujia Zhang, Buhao Deng, Peidong Gao, Mohammad Shiri, Fozi Alkaifi, Junxing Zhao, Jacqueline M. Stephens, Constantine A. Simintiras, Joseph Francis, Jiangwen Sun, Xing Fu

Computer Science Faculty Publications

Here, we present a protocol to isolate progenitor cells from mouse epididymal visceral adipose tissue and construct bulk RNA and assay for transposase-accessible chromatin with sequencing (ATAC-seq) libraries. We describe steps for adipose tissue collection, cell isolation, and cell staining and sorting. We then detail procedures for both ATAC-seq and RNA sequencing library construction. This protocol can also be applied to other tissues and cell types directly or with minor modifications.

For complete details on the use and execution of this protocol, please refer to Liu et al. (2023).¹

*¹ Liu, Q., Li, C., Deng, B., Gao, P., …

Dial "N" For Nxdomain: The Scale, Origin, And Security Implications Of Dns Queries To Non-Existent Domains, Gunnan Liu, Lin Jin, Shuai Hao, Yubao Zhang, Daiping Liu, Angelos Stavrou, Haining Wang

Computer Science Faculty Publications

Non-Existent Domain (NXDomain) is one type of the Domain Name System (DNS) error responses, indicating that the queried domain name does not exist and cannot be resolved. Unfortunately, little research has focused on understanding why and how NXDomain responses are generated, utilized, and exploited. In this paper, we conduct the first comprehensive and systematic study on NXDomain by investigating its scale, origin, and security implications. Utilizing a large-scale passive DNS database, we identify 146,363,745,785 NXDomains queried by DNS users between 2014 and 2022. Within these 146 billion NXDomains, 91 million of them hold historic WHOIS records, of which 5.3 million …

Toward A Generative Modeling Analysis Of Clas Exclusive 2𝜋 Photoproduction, T. Alghamdi, Y. Alanazi, M. Battaglieri, Ł. Bibrzycki, A. V. Golda, A. N. Hiller Blin, E. L. Isupov, Y. Li, L. Marsicano, W. Melnitchouk, V. I. Mokeev, G. Montaña, A. Pilloni, N. Sato, A. P. Szczepaniak, T. Vittorini

Computer Science Faculty Publications

AI-supported algorithms, particularly generative models, have been successfully used in a variety of different contexts. This work employs a generative modeling approach to unfold detector effects specifically tailored for exclusive reactions that involve multiparticle final states. Our study demonstrates the preservation of correlations between kinematic variables in a multidimensional phase space. We perform a full closure test on two-pion photoproduction pseudodata generated with a realistic model in the kinematics of the Jefferson Lab CLAS g11 experiment. The overlap of different reaction mechanisms leading to the same final state associated with the CLAS detector’s nontrivial effects represents an ideal test case …

A Hybrid Deep Learning Approach For Crude Oil Price Prediction, Hind Aldabagh, Xianrong Zheng, Ravi Mukkamala

Computer Science Faculty Publications

Crude oil is one of the world’s most important commodities. Its price can affect the global economy, as well as the economies of importing and exporting countries. As a result, forecasting the price of crude oil is essential for investors. However, crude oil price tends to fluctuate considerably during significant world events, such as the COVID-19 pandemic and geopolitical conflicts. In this paper, we propose a deep learning model for forecasting the crude oil price of one-step and multi-step ahead. The model extracts important features that impact crude oil prices and uses them to predict future prices. The prediction model …

TCf21 Marks Visceral Adipose Mesenchymal Progenitors And Functions As A Rate-Limiting Factor During Visceral Adipose Tissue Development, Qianglin Liu, Chaoyang Li, Buhao Deng, Peidong Gao, Leshan Wang, Yuxia Li, Mohammad Shiri, Fozi Alkaifi, Junxing Zhao, Jacqueline M. Stephens, Constantine A. Simintiras, Joseph Francis, Jiangwen Sun, Xing Fu

Computer Science Faculty Publications

Distinct locations of different white adipose depots suggest anatomy-specific developmental regulation, a relatively understudied concept. Here, we report a population of Tcf21 lineage cells (Tcf21 LCs) present exclusively in visceral adipose tissue (VAT) that dynamically contributes to VAT development and expansion. During development, the Tcf21 lineage gives rise to adipocytes. In adult mice, Tcf21 LCs transform into a fibrotic or quiescent state. Multiomics analyses show consistent gene expression and chromatin accessibility changes in Tcf21 LC, based on which we constructed a gene-regulatory network governing Tcf21 LC activities. Furthermore, …

Dfhic: A Dilated Full Convolution Model To Enhance The Resolution Of Hi-C Data, Bin Wang, Kun Liu, Yaohang Li, Jianxin Wang

Computer Science Faculty Publications

Motivation: Hi-C technology has been the most widely used chromosome conformation capture(3C) experiment that measures the frequency of all paired interactions in the entire genome, which is a powerful tool for studying the 3D structure of the genome. The fineness of the constructed genome structure depends on the resolution of Hi-C data. However, due to the fact that high-resolution Hi-C data require deep sequencing and thus high experimental cost, most available Hi-C data are in low-resolution. Hence, it is essential to enhance the quality of Hi-C data by developing the effective computational methods.

Results: In this work, we propose …

U.S. Senate And House Perspectives On Missile Defense Systems Opposed By Russia And China, Constance Valarie Baroudos

Walden Dissertations and Doctoral Studies

The United States and its allies and partners have deployed three missile defense systems to protect against Iranian and North Korean missile threats: the European Phased Adaptive Approach, Terminal High Altitude Area Defense, and Ground-based Missile Defense. Russia and China oppose these systems because they view them as undermining their strategic interests. The purpose of the present study was to better understand the perspectives of Senate and House Armed Services Committee HASC members about the three missile defense systems in congressional hearings. The three models of the congressional behavior model, the preference, simple party, and asymmetric categories, and neorealism and …

High School Teachers’ Experiences And Perceptions Facilitating Student Discourse And Collaborative Structures For English Language Learners In Biology, Chrissy Ann Brouwer

Walden Dissertations and Doctoral Studies

The problem that was addressed in this study was that the academic needs of English Language Learners (ELLs) were not being met in biology classes in high schools in the local district because teachers were not consistently facilitating instruction using the required strategies of student discourse and collaborative structures. The purpose of this qualitative study was to explore teachers’ successes, challenges, and need for supports when using the required strategies with their ELLs. Knowles’ theory of andragogy and Shulman’s theory of pedagogical content knowledge guided this study examining how the adults’ learning of the required strategies impacted their ability to …

Perceptions Of K–12 Educators Of Color On Ethnic Studies Curriculum And Teaching In Urban Public Schools, Tracy Castro-Gill

Walden Dissertations and Doctoral Studies

Retention of educators of color (EOC) is becoming a focal point in K–12 education because of the increasing demographic of students of color in K–12 urban public schools; however, a shortage of EOC exists in these schools in the United States due in part to disproportionate attrition rates for EOC compared to White educators. Little is known about the role curriculum may play in retaining EOC in K–12, urban public schools. The purpose of this qualitative critical narrative inquiry study was to explore how ethnic studies curriculum influences how EOC who teach ethnic studies perceive the teaching profession in K–12, …

Identifying The Serious Clinical Outcomes Of Adverse Reactions To Drugs By A Multi-Task Deep Learning Framework, Haochen Zhao, Peng Ni, Qichang Zhao, Xiao Liang, Di Ai, Shannon Erhardt, Jun Wang, Yaohang Li, Jiianxin Wang

Computer Science Faculty Publications

Adverse Drug Reactions (ADRs) have a direct impact on human health. As continuous pharmacovigilance and drug monitoring prove to be costly and time-consuming, computational methods have emerged as promising alternatives. However, most existing computational methods primarily focus on predicting whether or not the drug is associated with an adverse reaction and do not consider the core issue of drug benefit-risk assessment-whether the treatment outcome is serious when adverse drug reactions occur. To this end, we categorize serious clinical outcomes caused by adverse reactions to drugs into seven distinct classes and present a deep learning framework, so-called GCAP, for predicting the …

Validation Of A Process For Shared Decision-Making In Pediatrics, Douglas J Opel, Holly Hoa Vo, Nicolas Dundas, Heather Spielvogle, Amanda Mercer, Benjamin S Wilfond, Jonna Clark, Carrie L Heike, Elliott M Weiss, Mersine A Bryan, Seema K Shah, Carolyn A Mccarty, Jeffrey D Robinson, Jennifer Blumenthal-Barby, Jon Tilburt

Center for Medical Ethics and Health Policy Staff Publications

OBJECTIVE: We sought to confirm, refute, or modify a 4-step process for implementing shared decision-making (SDM) in pediatrics that involves determining 1) if the decision includes >1 medically reasonable option; 2) if one option has a favorable medical benefit-burden ratio compared to other options; and 3) parents' preferences regarding the options; then 4) calibrating the SDM approach based on other relevant decision characteristics.

METHODS: We videotaped a purposive sample of pediatric inpatient and outpatient encounters at a single US children's hospital. Clinicians from 7 clinical services (craniofacial, neonatology, oncology, pulmonary, pediatric intensive care, hospital medicine, and sports medicine) were eligible. …