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Articles 10381 - 10410 of 163630
Full-Text Articles in Entire DC Network
Processing Of Polymers Stress Relaxation Curves Using Machine Learning Methods, Anton S. Chepurnenko, Tatiana N. Kondratieva, Ebrahim Al-Wali
Processing Of Polymers Stress Relaxation Curves Using Machine Learning Methods, Anton S. Chepurnenko, Tatiana N. Kondratieva, Ebrahim Al-Wali
Baghdad Science Journal
Currently, one of the topical areas of application of machine learning methods is the prediction of material characteristics. The aim of this work is to develop machine learning models for determining the rheological properties of polymers from experimental stress relaxation curves. The paper presents an overview of the main directions of metaheuristic approaches (local search, evolutionary algorithms) to solving combinatorial optimization problems. Metaheuristic algorithms for solving some important combinatorial optimization problems are described, with special emphasis on the construction of decision trees. A comparative analysis of algorithms for solving the regression problem in CatBoost Regressor has been carried out. The …
Synthesis And Antibacterial Evaluation For Some New Schiff-Bases Derived From P-Aminoacetanilide, Eman M. Hussain
Synthesis And Antibacterial Evaluation For Some New Schiff-Bases Derived From P-Aminoacetanilide, Eman M. Hussain
Baghdad Science Journal
Derivatives of Schiff-bases possess a great importance in pharmaceutical chemistry. They can be used for synthesizing different types of bioactive compounds. In this paper, derivatives of new Schiff bases have been synthesized from several serial steps. The acid (I) was synthesized from the reaction of dichloroethanoic acid with 2 moles of p-aminoacetanilide. New acid (I) converted to its ester (II) via the reaction of (I) with dimethyl sulphate in the present of anhydrous of sodium carbonate and dry acetone. Acid hydrazide (III) has been synthesized by adding 80% of hydrazine hydrate to the new ester using ethanol as a solvent. …
An Observation And Analysis The Role Of Convolutional Neural Network Towards Lung Cancer Prediction, Suranjana Mitra, Annwesha Banerjee Majumder, Tanusree Saha
An Observation And Analysis The Role Of Convolutional Neural Network Towards Lung Cancer Prediction, Suranjana Mitra, Annwesha Banerjee Majumder, Tanusree Saha
Baghdad Science Journal
Lung cancer is one of the most serious and prevalent diseases, causing many deaths each year. Though CT scan images are mostly used in the diagnosis of cancer, the assessment of scans is an error-prone and time-consuming task. Machine learning and AI-based models can identify and classify types of lung cancer quite accurately, which helps in the early-stage detection of lung cancer that can increase the survival rate. In this paper, Convolutional Neural Network is used to classify Adenocarcinoma, squamous cell carcinoma and normal case CT scan images from the Chest CT Scan Images Dataset using different combinations of hidden …
Red Ginger's Anti-Anxiety Effect On Balb/C Strain Mice (Mus Musculus) Pro-Inflammatory And Anti-Inflammatory Measurements As Anxiety Model, Ira Aini Dania, Aldy Safruddin Rambe, Urip Harahap, Elmeida Effendy, Tuti Wahmurti, Syafruddin Ilyas, Muhammad Rusda, Mustafa Mahmud Amin
Red Ginger's Anti-Anxiety Effect On Balb/C Strain Mice (Mus Musculus) Pro-Inflammatory And Anti-Inflammatory Measurements As Anxiety Model, Ira Aini Dania, Aldy Safruddin Rambe, Urip Harahap, Elmeida Effendy, Tuti Wahmurti, Syafruddin Ilyas, Muhammad Rusda, Mustafa Mahmud Amin
Baghdad Science Journal
There is a correlation between the occurrence of anxiety and the production of inflammatory mediators, and red ginger rhizome is a well-known herbal product with a high content of phenolic and flavonoid compounds that can be used as anti-inflammatories and antioxidants. The aim of study to evaluate the effect of red ginger as antianxiety in mice (Mus musculus) BALB/c strain by measuring levels of TNF-α, IL-6 and IL-10. Anxiety model mice were carried out by giving treatment with the Forced Swimming Test (FST) for 7 days then assessed by carrying out the Elevated Plus Maze for Mice (EPM) test for …
Polymerization Of Acrylamide N-Methylene Lactic And Glycolic Acid, Sevara Khazratkulova, Nodira Zokirova, Busora Mukhamedova, Basant Lal, Orifjon Khamidov, Elyor Berdimurodov, Guloy Alieva, Ahmad Hosseini-Bandegharaei, Nizomiddin Aliev
Polymerization Of Acrylamide N-Methylene Lactic And Glycolic Acid, Sevara Khazratkulova, Nodira Zokirova, Busora Mukhamedova, Basant Lal, Orifjon Khamidov, Elyor Berdimurodov, Guloy Alieva, Ahmad Hosseini-Bandegharaei, Nizomiddin Aliev
Baghdad Science Journal
In this research work, the novel polymer base on acrylamide N-methylene lactic and glycolic acid was synthesized and its structural performances were identified by the IR, 1H NMR and 13C NMR spectroscopic investigations. The influencing factors and kinetics of polymerization, viscosity performance were studied and quantum chemical calculations were used to identify the correlation between the structure and properties. It was determined that the polymerization rate of the examined monomers in an aqueous solution, in the presence of DAA, adheres to the standard rules for radical polymerization of acrylamide monomers in solution. An investigation into the pH solution's impact on …
Synthesis Of Multifunctional Polymers Based On Tert-Butyl Acrylamide/Octyl Acrylate As Lubricant Additives And Adsorbents For Copper Ion From Aqueous Solution, Ameen Hadi Mohammed, Enaam Fadil Mousa, Ameera Hassan Hamed, Mansor Ahmad
Synthesis Of Multifunctional Polymers Based On Tert-Butyl Acrylamide/Octyl Acrylate As Lubricant Additives And Adsorbents For Copper Ion From Aqueous Solution, Ameen Hadi Mohammed, Enaam Fadil Mousa, Ameera Hassan Hamed, Mansor Ahmad
Baghdad Science Journal
Two homopolymeric and three copolymeric additives for base oil were synthesized using octyl acrylate (OA) and tert-butyl acrylamide (TBA) monomers. The two additives named P1 and P2 are the homopolymers of TBA and OA, respectively, whereas copolymeric additives named Co1, Co2, and Co3 were synthesized by varying the ratios of TBA:OA as 1:3, 3:1 and 1:1, respectively. The prepared polymers were characterized by Fourier Transform Infrared (FTIR). Based on the solubility of synthesized polymers in base oil and reactivity ratios of TBA/OA copolymer (0.222, 0.434) calculated by Fineman-Ross method, P2, Co1, Co2 and Co3 were selected to evaluate their performance …
Ecofriendly Control For Stored-Product Pest, Oryzaephilus Surinamensis (Order: Coleoptera, Family: Silvanidae), Fatma H. Galal
Ecofriendly Control For Stored-Product Pest, Oryzaephilus Surinamensis (Order: Coleoptera, Family: Silvanidae), Fatma H. Galal
Baghdad Science Journal
Dates are considered one of the most important foods consumed in Arab countries. Dates are commonly infested with the sawtoothed grain beetle, Oryzaephilus surinamensis. Consequently, the date yield, quantity, and quality (economic value and seed viability) are negatively affected. This study was designed to investigate the effectiveness of air evacuation as eco-friendly and safe control method against adult O. surinamensis. Insects were obtained from the infested date purchased from a private store in sakaka city, Aljouf region, Saudi Arabia. Air evacuation (using a vacuum pump) and food deprivation were applied to O. surinamensis, and insect mortality was observed daily in …
Investigating The Influence Of Precursor Concentration On The Photodegradation Of Methylene Blue Using Biosynthesized Zno From Pometia Pinnata Leaf Extracts, Ari Sulistyo Rini, Yolanda Rati, Seliana Putri, Rahmi Dewi
Investigating The Influence Of Precursor Concentration On The Photodegradation Of Methylene Blue Using Biosynthesized Zno From Pometia Pinnata Leaf Extracts, Ari Sulistyo Rini, Yolanda Rati, Seliana Putri, Rahmi Dewi
Baghdad Science Journal
The ZnO nanoparticles were synthesized at various precursor concentrations i.e. 0.05, 0.1, and 0.5 M by biosynthesis method based on Pometia pinnata Leaf Extracts. Initial nanoparticle concentration influenced the optical bandgap, shape, and structure of nanoparticles. The photodegradation process was carried out under UV illumination. The efficiency of MB degradation was determined by measuring the decrease in MB concentration and by analyzing the optical absorption at 663 nm recorded by UV-Vis spectroscopy. Results showed that the biosynthesized ZnO nanoparticles exhibited efficient photodegradation of MB, with a maximum degradation rate of 80% after 90 minutes of exposure to UV-C light. The …
A Novel System For Confidential Medical Data Storage Using Chaskey Encryption And Blockchain Technology, Aymen Mudheher Badr, Lamia Chaari Fourati, Samiha Ayed
A Novel System For Confidential Medical Data Storage Using Chaskey Encryption And Blockchain Technology, Aymen Mudheher Badr, Lamia Chaari Fourati, Samiha Ayed
Baghdad Science Journal
Secure storage of confidential medical information is critical to healthcare organizations seeking to protect patient's privacy and comply with regulatory requirements. This paper presents a new scheme for secure storage of medical data using Chaskey cryptography and blockchain technology. The system uses Chaskey encryption to ensure integrity and confidentiality of medical data, blockchain technology to provide a scalable and decentralized storage solution. The system also uses Bflow segmentation and vertical segmentation technologies to enhance scalability and manage the stored data. In addition, the system uses smart contracts to enforce access control policies and other security measures. The description of the …
Enhancing Smart Cities With Iot And Cloud Computing: A Study On Integrating Wireless Ad Hoc Networks For Efficient Communication, Haider Mohammed Abdulhadi, Yousra Abdul Alsahib S. Aldeen, Maryam A. Yousif, Mays Jalal Jaseem, Syed Hamid Hussain Madni
Enhancing Smart Cities With Iot And Cloud Computing: A Study On Integrating Wireless Ad Hoc Networks For Efficient Communication, Haider Mohammed Abdulhadi, Yousra Abdul Alsahib S. Aldeen, Maryam A. Yousif, Mays Jalal Jaseem, Syed Hamid Hussain Madni
Baghdad Science Journal
Smart cities have recently undergone a fundamental evolution that has greatly increased their potentials. In reality, recent advances in the Internet of Things (IoT) have created new opportunities by solving a number of critical issues that are allowing innovations for smart cities as well as the creation and computerization of cutting-edge services and applications for the many city partners. In order to further the development of smart cities toward compelling sharing and connection, this study will explore the information innovation in smart cities in light of the Internet of Things (IoT) and cloud computing (CC). IoT data is first collected …
Uab Is One Of The First Us Medical Schools To Give Portable Ultrasound Unit Access To All Students. Here's Why., Matt Windsor
Uab Is One Of The First Us Medical Schools To Give Portable Ultrasound Unit Access To All Students. Here's Why., Matt Windsor
Browse All News
No abstract provided.
Art399 Portfolio, Thomas Townsend Jr
Art399 Portfolio, Thomas Townsend Jr
Professional Practices (ART 399)
When I was young I wasn't much into art. I liked doing my owns thing and looking at cool images and colors that grabbed my attention, now really understanding that I actually liked art. The way I really knew how to communicate my feelings was to draw them out since I struggled verbally expressing them. I really didn't know exactly what I was doing but I was drawing or doing other creative ways to express the way I was feeling at the moment to others. Sometimes to this day I still do that but I'm at lot better at expressing …
Teresa Hill Art 399 Portfolio, Teresa Hill
Teresa Hill Art 399 Portfolio, Teresa Hill
Professional Practices (ART 399)
Aside from the aesthetics of cartoons and video games that I was attracted to in childhood; other influences that often guide where works would go are personal experiences, our connection with nature and others, the development of the imagination, and the human eye. The pieces made from that influence contain something tied back to others, whether it is the use of various warm/cool hues, the use of nature and flowers, colorful clothing on figures, or hands and legs being slightly longer than the rest of a figure’s proportions. Artists like Yayoi Kusama, Bonnie Seeman, and Hayao Miyazaki have also impacted …
Michael Ridenour 399 Art Portfolio, Michael Ridenour
Michael Ridenour 399 Art Portfolio, Michael Ridenour
Professional Practices (ART 399)
A plethora of my artwork is based on imaginary animals and their role in reality or fantasy. I utilize pencil and charcoal to add depth and feeling to the piece whether it is colored or monochromatic. To make the drawings, I first gather some ideas from creatures from mythology or the virtual landscape and add some features of my own design. This passion for capturing creatures, real or fictional, can utilize their unusual adaptations from a scientific point of view as a way to merge two of my interests. I have always been fascinated by animals, especially mythical ones or …
Art399 Portfolio, Wesley Hammer
Art399 Portfolio, Wesley Hammer
Professional Practices (ART 399)
Since a young age, my art has been a proper channel in which it allows me to express my own lived experiences by visually processing the thoughts and emotions that are made through everyday living. The process in which art is made deepens the understanding of oneself. Why I bring into existence art is why I exist. One of the most important influences to the creation of my works is the fact that I am transgender. The way in which I exist in the world as well as the relationships created are also influenced by this aspect. As I continue …
Amber Ryan Final Portfolio, Amber E. Ryan
Amber Ryan Final Portfolio, Amber E. Ryan
Professional Practices (ART 399)
My personal journey and the lived experience of women in society inspire my work. I speak to my own experiences and thoughts as a woman. I force people into a place of discomfort, causing them to think deeply about how society speaks to women and what is taught to us from birth, leaving them with thoughts that linger long after they have walked away. This gives them a window into my intrusive thoughts, traumas, and emotions. The Tulip Field speaks to the manner in which society deals with the sex industry and sex workers today as opposed to how they …
Shifting The Academic Leadership Paradigm: Culturally Responsive Associate Deans In Illinois Community Colleges, Cathy Y. Taylor
Shifting The Academic Leadership Paradigm: Culturally Responsive Associate Deans In Illinois Community Colleges, Cathy Y. Taylor
Theses and Dissertations
This study explored how associate deans in Illinois community colleges understand and practice culturally responsive leadership (CRL) in their institutions. The conceptual framework for this study is composed of the Culturally Responsive School Leadership (CRSL) model in the K-12 system first proposed by Khalifa et al. (2016) and the Applied Critical Leadership (ACL) model for higher education leaders by Santamaria et al. (2016). The study used the convergent parallel mixed-methods approach to simultaneously collect quantitative and qualitative data from associate deans in Illinois community colleges to measure how they understood and practiced culturally responsive leadership in their institutions. The study …
Alarm With Care-A De-Implementation Strategy To Reduce Fall Prevention Alarm Use In Us Hospitals: A Study Protocol For A Hybrid 2 Effectiveness-Implementation Trial., Kea Turner, Molly Mcnett, Catima Potter, Emily Cramer, Mona Al Taweel, Ronald I. Shorr, Lorraine C. Mion
Alarm With Care-A De-Implementation Strategy To Reduce Fall Prevention Alarm Use In Us Hospitals: A Study Protocol For A Hybrid 2 Effectiveness-Implementation Trial., Kea Turner, Molly Mcnett, Catima Potter, Emily Cramer, Mona Al Taweel, Ronald I. Shorr, Lorraine C. Mion
Manuscripts, Articles, Book Chapters and Other Papers
BACKGROUND: Fall prevention alarms are commonly used among US hospitals as a fall prevention strategy despite limited evidence of effectiveness. Further, fall prevention alarms are harmful to healthcare staff (e.g., alarm fatigue) and patients (e.g., sleep disturbance, mobility restriction). There is a need for research to develop and test strategies for reducing use of fall prevention alarms in US hospitals.
METHODS: To address this gap, we propose testing the effectiveness and implementation of Alarm with Care, a de-implementation strategy to reduce fall prevention alarm use using a stepped-wedge randomized controlled trial among 30 adult medical or medical surgical units from …
Exploring The Uncommon: A Case Report On Localized Peritonitis Caused By Ingested Toothpick, Narmeen Asif, Salva Shariq, Abdul Rehman Alvi
Exploring The Uncommon: A Case Report On Localized Peritonitis Caused By Ingested Toothpick, Narmeen Asif, Salva Shariq, Abdul Rehman Alvi
Department of Surgery Docs
Introduction: Bowel perforation is a serious emergency. Occasionally, sharp objects like toothpicks can get stuck in narrow parts of the small intestine, potentially resulting in impaction, obstruction, or perforation.
Presentation of case: A 20-year-old male arrived at our hospital's emergency department with sudden, severe abdominal pain persisting for 24 h. On examination, his abdomen showed tenderness, and bowel sounds were reduced. Contrast-enhanced computed tomography (CECT) indicated possible small intestine inflammation due to a foreign object and a diagnostic laparoscopy revealed a hyperemic terminal ileum.
Discussion: This case involves ileal perforation from an unnoticed toothpick ingestion. Detecting foreign object perforations is …
Uni Holiday Concert Featuring Jazz Band One, Cecilians, And Concert Chorale, December 5, 2023 [Program], University Of Northern Iowa. School Of Music.
Uni Holiday Concert Featuring Jazz Band One, Cecilians, And Concert Chorale, December 5, 2023 [Program], University Of Northern Iowa. School Of Music.
Music Recital Programs
Program of a music recital given by faculty, students, or guest artists from the School of Music at the University of Northern Iowa.
Uni Clarinet Clarinet Studio Recital, December 5, 2023 [Program], University Of Northern Iowa. School Of Music.
Uni Clarinet Clarinet Studio Recital, December 5, 2023 [Program], University Of Northern Iowa. School Of Music.
Music Recital Programs
Program of a music recitals given by faculty, students, or guest artists from the School of Music at the University of Northern Iowa.
Trustee's Objection To Competing Plans
Trustee's Objection To Competing Plans
Catholic Dioceses in Bankruptcy
No abstract provided.
A Generalized Kodaira Vanishing Theorem For Lie Algebroids And A Riemann–Roch Theorem For Singular Foliation, Tengzhou Hu
A Generalized Kodaira Vanishing Theorem For Lie Algebroids And A Riemann–Roch Theorem For Singular Foliation, Tengzhou Hu
Arts & Sciences Graduate Student Theses and Dissertations
A Lie algebroid is a generalization of Lie algebra that provides a general framework to describe the symmetries of a manifold. In this thesis, we first generalize the Kodaira vanishing theorem, which is a basic result in complex geometry, to K\"{a}hler Lie algebroids. The generalization of the Kodaira vanishing theorem states that the kernel of the Lie algebroid Laplace operator on Lie algebroid positive line bundle-valued $(p,q)$-forms vanishes when $p+q$ is sufficiently large. The most difficult part of the proof of the generalized Kodaira vanishing theorem is the generalization of the K\"{a}hler identities to Lie algebroids. Secondly, we introduce Lie …
20231205_Library’S Entry-Level Floor Is Getting A Refresh!, Sally Bowler-Hill
20231205_Library’S Entry-Level Floor Is Getting A Refresh!, Sally Bowler-Hill
HSLIC Blog Post
No abstract provided.
Registration Status, Reading Interest Level, And Library Use Habits Of Teaching Staff In Akwa Ibom State University, Nigeria: An Investigation, Nse Emmanuel Akwang Phd, Cln
Registration Status, Reading Interest Level, And Library Use Habits Of Teaching Staff In Akwa Ibom State University, Nigeria: An Investigation, Nse Emmanuel Akwang Phd, Cln
Library Philosophy and Practice (e-journal)
The study investigated registration status, reading interest level, and library use habits of teaching staff in Akwa Ibom State University, Nigeria. The study adopted survey research design, with a total population of 467 teaching staff from eight (8) academic faculties. Out of the total study population, a sample of 212 was selected using an online sample calculator known as Survey Monkey Sample Size Calculator at 95% confidence level and confidence interval of 5%. The instrument used for data collection was a researcher-developed questionnaire, which was subjected to face and content validity and reliability coefficient of 0.80 using Cronbach’s Alpha technique. …
Systematic Analysis Of Adoption Of Innovative Technologies In The Provision Of Electronic Information Services In Public University Libraries In Akwa Ibom State, Nigeria, Chukwudi P. Mensa Phd, Inemesit Udom Udoh Mr., Priscilla Odeyovwi Osiebe Mrs.
Systematic Analysis Of Adoption Of Innovative Technologies In The Provision Of Electronic Information Services In Public University Libraries In Akwa Ibom State, Nigeria, Chukwudi P. Mensa Phd, Inemesit Udom Udoh Mr., Priscilla Odeyovwi Osiebe Mrs.
Library Philosophy and Practice (e-journal)
This study systematically analysed the adoption of innovative technologies in the provision of electronic information services in public university libraries in Akwa Ibom State, Nigeria. It adopted the descriptive survey design with three specific objectives. The population of the study consisted of eighty-nine (89) librarians and library officers from Akwa Ibom State University (AKSU) and University of Uyo (UNIUYO) libraries. The census sampling technique was adopted in the study. Data for the study were collected using structured questionnaire with a reliability index of 0.79 using Cronbach Alpha reliability coefficient. The data collected were analysed using descriptive statistics of percentage counts, …
College Student Mental Health In The Covid-19 Era: Results Of An Expressive Writing Prompt, Carissa Daniello-Heyda, Kevin Hynes, Rachel R. Tambling
College Student Mental Health In The Covid-19 Era: Results Of An Expressive Writing Prompt, Carissa Daniello-Heyda, Kevin Hynes, Rachel R. Tambling
The Qualitative Report
The novel SARS-CoV-2, or coronavirus, has greatly altered the landscape of college life for students across the United States. The ever-present health concerns and quarantine have been linked to increased anxiety, depression, stress, and post-traumatic stress disorder. To this end, we examined the influence of the COVID-19 pandemic on the psychosocial health of college students. We explored the impact of COVID-19 on levels of stress and distress in college students using a qualitative expressive writing methodology. Results of this study suggested that the college students included in the sample were moderately distressed – their scores on inventories of depression, anxiety, …
Futuros Posibles En Adversidad: Las Experiencias De Rebusque De Familias En Medellín Durante La Pandemia Covid-19, Doris Elena Muñoz-Zapata, Katherine García-Vásquez, Johanna Jazmín Zapata-Posada
Futuros Posibles En Adversidad: Las Experiencias De Rebusque De Familias En Medellín Durante La Pandemia Covid-19, Doris Elena Muñoz-Zapata, Katherine García-Vásquez, Johanna Jazmín Zapata-Posada
The Qualitative Report
Este artículo es resultado de una investigación sobre los significados atribuidos por las familias a las experiencias de satisfacción de necesidades básicas y el rebusque para la supervivencia durante el confinamiento obligatorio, derivado por la pandemia COVID-19. Se realizó una investigación cualitativa con diseño fenomenológico, método narrativo, con seis familias en situación de exclusión social y pobreza, mediante la estrategia metodológica de visita domiciliaria, en Medellín, Colombia. Se concluye que, pese a la falta de oportunidades laborales para la satisfacción de las necesidades básicas, de manera paradójica, fue una oportunidad para descansar y compartir en el entorno familiar, dado que …
From Mother To Infant, From Placenta To Gut: Understanding Varied Microbiome Profiles In Neonates, Riadh Cheddadi, Venkata Yeramilli, Colin Martin
From Mother To Infant, From Placenta To Gut: Understanding Varied Microbiome Profiles In Neonates, Riadh Cheddadi, Venkata Yeramilli, Colin Martin
2020-Current year OA Pubs
The field of human microbiome and gut microbial diversity research has witnessed a profound transformation, driven by advances in omics technologies. These advancements have unveiled essential connections between microbiome alterations and severe conditions, prompting the development of new frameworks through epidemiological studies. Traditionally, it was believed that each individual harbored unique microbial communities acquired early in life, evolving over the course of their lifetime, with little acknowledgment of any prenatal microbial development, but recent research challenges this belief. The neonatal microbiome's onset, influenced by factors like delivery mode and maternal health, remains a subject of intense debate, hinting at potential …
Dna Methylation-Mediated Rbpjk Suppression Protects Against Fracture Nonunion Caused By Systemic Inflammation, Ding Xiao, Liang Fang, Zhongting Liu, Yonghua He, Jun Ying, Haocheng Qin, Aiwu Lu, Meng Shi, Tiandao Li, Bo Zhang, Jianjun Guan, Cuicui Wang, Yousef Abu-Amer, Jie Shen
Dna Methylation-Mediated Rbpjk Suppression Protects Against Fracture Nonunion Caused By Systemic Inflammation, Ding Xiao, Liang Fang, Zhongting Liu, Yonghua He, Jun Ying, Haocheng Qin, Aiwu Lu, Meng Shi, Tiandao Li, Bo Zhang, Jianjun Guan, Cuicui Wang, Yousef Abu-Amer, Jie Shen
2020-Current year OA Pubs
Challenging skeletal repairs are frequently seen in patients experiencing systemic inflammation. To tackle the complexity and heterogeneity of the skeletal repair process, we performed single-cell RNA sequencing and revealed that progenitor cells were one of the major lineages responsive to elevated inflammation and this response adversely affected progenitor differentiation by upregulation of Rbpjk in fracture nonunion. We then validated the interplay between inflammation (via constitutive activation of Ikk2, Ikk2ca) and Rbpjk specifically in progenitors by using genetic animal models. Focusing on epigenetic regulation, we identified Rbpjk as a direct target of Dnmt3b. Mechanistically, inflammation decreased Dnmt3b expression in progenitor cells, …