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Articles 1021 - 1050 of 163016
Full-Text Articles in Entire DC Network
Chinese Ecological Attitudes In The Modern Era And Foundations Of Taoist Philosophy: A Case Study Of The “Biodiversity Conservation In China” Whitepaper, Yao Siqi
Journal of Letters
This paper analyzed (1) the language representations of attitude resources in the “Biodiversity Conservation in China” whitepaper based on Martin and White’s appraisal theory, and (2) hidden modern Chinese eco-attitudes as reflected in the whitepaper. The findings were that the whitepaper used all three attitude subcategories: (1) judgment, (2) appreciation, and (3) affect, in decreasing order of significance. Judgment and appreciation were highly proportional and positive, while distribution of affect was minimal. Chinese eco-attitudes in the new era, as reflected in the white paper, may be considered from three perspectives: overall outlook, equality and future perspective. Ecological awareness of respecting …
T. M. Scanlon On Normativity: A Methodological Exploration, Piyarudee Chaiyaporn
T. M. Scanlon On Normativity: A Methodological Exploration, Piyarudee Chaiyaporn
Journal of Letters
This article argues that T. M. Scanlon’s account of normativity, grounded in the concepts of reasons and reason relations, is strongly justified as it attains substantive coherence through the method of reflective equilibrium. The argument focuses on three strategies employed by Scanlon in his critical analysis of Joseph Raz’s and Jonathan Dancy’s alternative accounts of normativity, namely, (1) characterization, (2) the pursuit of narrow reflective equilibrium (N-RE), and (3) the pursuit of wide reflective equilibrium (W-RE). In addition to the robustness provided by substantive coherence, which safeguards his account against Justin Clarke-Doane’s objection regarding reliability, Scanlon is also able to …
Medical Student Advising During Virtual Residency Recruitment: Results Of A National Survey Of Internal Medicine Clerkship And Sub-Internship Directors, Irene Alexandraki, Nadia Ismail, Cindy J Lai, Nicholas S Duca, Temple Ratcliffe, Michael Kisielewski, Amber T Pincavage
Medical Student Advising During Virtual Residency Recruitment: Results Of A National Survey Of Internal Medicine Clerkship And Sub-Internship Directors, Irene Alexandraki, Nadia Ismail, Cindy J Lai, Nicholas S Duca, Temple Ratcliffe, Michael Kisielewski, Amber T Pincavage
Faculty, Staff and Students Publications
INTRODUCTION: The residency application process is a critical time for medical students. The COVID-19 pandemic prompted changes to the residency recruitment procedures with the conversion of interviews to a virtual format. For medical school advisors guiding students on an all-virtual residency application process brought uncertainty to their advising practices. Thus, this study aimed to identify advising practices during the 2021 virtual application cycle.
METHODS: We administered an IRB-exempt national survey through the Clerkship Directors in Internal Medicine to 186 internal medicine core/co-/associate/assistant clerkship directors and sub-internship directors representing 140 Liaison Committee on Medical Education-accredited U.S./U.S.-territory-based medical schools in spring 2021. …
Temperature Correction In Optical Enzymatic Assays Using Thermochromic Liquid Crystals, Herschel Watkins, Pete Richards
Temperature Correction In Optical Enzymatic Assays Using Thermochromic Liquid Crystals, Herschel Watkins, Pete Richards
Defensive Publications Series
Many point of care devices use enzymatic assays to quantify the analyte of interest. Enzyme efficiency can be strongly temperature dependent. Therefore, it is important to correct for temperature effects during the analysis of experimental results. This disclosure describes techniques to correct for temperature effects in enzymatic assaying by using thermochromic liquid crystals in parallel with the enzymatic assay to track real time temperature variation at the assay location. Temperature can thus be tracked at the precise assay location, rather than at some nearby point. By thus directly and empirically measuring temperature at the location that matters, assumptions about the …
How To Deliver An Effective Course: A Student's Perspective, Jaipaul Udaipaul, Lynne N. Kennette
How To Deliver An Effective Course: A Student's Perspective, Jaipaul Udaipaul, Lynne N. Kennette
Journal of Educational Research and Practice
Certain course features, such as engaging delivery, can benefit student learning. This essay presents one student’s opinion of what made for an effective introductory psychology course. The student provides his perspective on various features of the recently completed psychology course and how those elements supported his learning. The elements he identified included various ongoing knowledge checks, test reviews, tests, in-class engagement, personalized touchpoints, scaffolding, and student feedback. For each, the course instructor explains the pedagogical underpinnings of her choices. Faculty may find a student’s perspective on courses valuable as they consider their pedagogical decisions in terms of course design and …
Guest Delight: The Influence Of Sustainable Performance And Guests' Perceived Health And Safety, Mi Ran Kim, Eunsil Lee, Jisun Lee
Guest Delight: The Influence Of Sustainable Performance And Guests' Perceived Health And Safety, Mi Ran Kim, Eunsil Lee, Jisun Lee
ICHRIE Research Reports
Recently, the COVID-19 pandemic has further emphasized the importance of guests’ health, safety, and well-being in the hotel industry. Further, in today’s highly competitive environment, hotels must orchestrate memorable experiences for guests to realize their value and become ambassadors for the brand. The purpose of this research is to explore the antecedents (i.e., sustainable performance, safety, and health) and the outcomes (i.e., brand love, trust, and willingness to pay more) of customer delight. Surveys will be distributed to hotel guests and the results can provide insights and implications for scholars and practitioners to better understand the concept of customer delight.
Toxic Leadership: Managerial Implications For Tourism And Hospitality Business, Alessandro Cavelzani
Toxic Leadership: Managerial Implications For Tourism And Hospitality Business, Alessandro Cavelzani
ICHRIE Research Reports
There is growing attention on research about dysfunctional management issues, specifically regarding toxic leadership, which lead to deleterious consequences in business. When a leader enacts toxic behaviors rather than providing support and realistic directions, it will cause severe stress, burnout, and passive-aggressive dynamics on their team, negatively affecting guest experiences. Therefore, this transactional paper aims at developing managers’ awareness of the toxic leadership issue, enlightening how to recognize and detect it. Also, to contribute to reducing job stress and promoting mental health at the workplace, we suggest some recommendations on how companies can handle the toxic leadership phenomenon by enhancing …
Alex Shevrin Venet’S Equity-Centered Trauma-Informed Education–A Book Review, Kimberly A. Mahovsky, Anne O. Davidson
Alex Shevrin Venet’S Equity-Centered Trauma-Informed Education–A Book Review, Kimberly A. Mahovsky, Anne O. Davidson
Journal of Educational Research and Innovation
This review provides an overview of Alex Venet’s Equity-Centered Trauma-Informed Education and a critical analysis by teacher educators charged to include equity-centered trauma-informed practices in all education courses. This book serves as a catalyst for conversations around equity-centered and trauma-informed education as many states push for all educators in K-12 schools to recognize the prevalence of adversity and create professional development for their instructors to incorporate these practices in their classrooms. The review will evaluate the author’s organization of the book and the five shifts Venet suggests for movement toward educational equity.
The Effect Of Gameplay On The Creative Self-Efficacy Of Educators In Hypothetical Classroom Management Situations, Weihsuan Lo, Erin C. Wachter, Chelsea R. Miller
The Effect Of Gameplay On The Creative Self-Efficacy Of Educators In Hypothetical Classroom Management Situations, Weihsuan Lo, Erin C. Wachter, Chelsea R. Miller
Journal of Educational Research and Innovation
In an ever-changing emotional, psychological, and physically developing world of education, it is important for educators to adapt creative skills to meet learners' needs. It is paramount for educators to develop creative skills to meet the needs of their learners and demonstrate effective classroom management. There is a gap between preservice teacher preparation and the reality of the day-to-day demands of educators. Game-based learning can provide a measure to fill that gap by providing a simulated experience for preservice teachers to encounter possible challenging scenarios. This concept of educational gameplay uses interactive learning that can improve the classroom response to …
A Descriptive Study On Shah Abdul Latif Public Library Shahdadpur, Sindh; Pakistan., Sher Muhammad Burdi , Primary School Teacher At G.B.P.S Al Mansoora Colony Sanghar, Arif Ali Bhatti, Nusrat Shaheen .
A Descriptive Study On Shah Abdul Latif Public Library Shahdadpur, Sindh; Pakistan., Sher Muhammad Burdi , Primary School Teacher At G.B.P.S Al Mansoora Colony Sanghar, Arif Ali Bhatti, Nusrat Shaheen .
Library Philosophy and Practice (e-journal)
This descriptive study examined the Shah Abdul Latif Public Library in Shahdadpur, Sindh, Pakistan, with the aim of understanding its features, resources, services, and knowledge dissemination and community engagement. The study used mixed-method approach and collected data was presented in simple tables and charts. Research provided comprehensive description with aim of rules and regulations of library and the literature review explored the significance of public libraries as information centers and their role in community engagement and lifelong learning. The historical background of library may provide the understanding of basic foundation of public libraries in Pakistani cities, like Shahdadpur. During the …
Remote Sensing And Radiometric Studies Of Gabal Kadabora – Gabal Umm Ghieg And Its Surrounding Area, Central Eastern Desert, Egypt, Hend Ibrahim Abd-Elmageed, Mohamed Elsadek M. Sabra, Tharwat Ahmed Abdel Fattah, Elhamy Tarabees, Mohamed A.S. Youssef, Al Sayeda Abou Shagar
Remote Sensing And Radiometric Studies Of Gabal Kadabora – Gabal Umm Ghieg And Its Surrounding Area, Central Eastern Desert, Egypt, Hend Ibrahim Abd-Elmageed, Mohamed Elsadek M. Sabra, Tharwat Ahmed Abdel Fattah, Elhamy Tarabees, Mohamed A.S. Youssef, Al Sayeda Abou Shagar
Blue Economy
Gabal Kadabora - Gabal Umm Gheig and its surrounding area is located in Central Eastern Desert (CED). This region is dominated by igneous, metamorphic, and sedimentary rocks ranging in age from the Late Proterozoic to the Quaternary. Based on the published geological map, Digital elevation model (DEM) and Radiometric maps three structural trends; NW-SE, NE-SW and N-S directions are detected. Spectrometric data vary from 1.86 to 184.58 μR/h for the total count (T.C), from 0.08 to 4.07 % for (K), from 0.11 to 11.25 ppm for eU, and from 0.4 to 29.33 ppm for eTh . Identification of radiometric anomalies …
Long-Term Variations In The Salinity Off The Egyptian Mediterranean Coast, Ebtessam E. Mohamed, Amna S. Dabbous, Hussein I. Maiyza, Tarek M. El-Geziry
Long-Term Variations In The Salinity Off The Egyptian Mediterranean Coast, Ebtessam E. Mohamed, Amna S. Dabbous, Hussein I. Maiyza, Tarek M. El-Geziry
Blue Economy
The variability in seawater salinity, an indicator of the global hydrological cycle, is crucial in basin-scale circulation and so many dynamical processes from basin to global scale. Salinity is significant for marine science because fluctuations in salinity can affect physical processes such as climate change, ocean current variations, and water mass formation. From a biological perspective, variations in salinity may pose a threat to marine animals and disrupt their normal functioning. In this study, the long-term variability of salinity in the photic zone (0-200 m) of the Egyptian Mediterranean Sea is examined using an extended data set from 1950 to …
Blue Economic Potency Of Marine Invertebrates For Bio-Drug Discovery, Hassan A.H. Ibrahim, Hanan M. Abdelnaby, Samia S. Abouelkheir, Hamdy A. Abo-Taleb, Nermeen A. El Sersy
Blue Economic Potency Of Marine Invertebrates For Bio-Drug Discovery, Hassan A.H. Ibrahim, Hanan M. Abdelnaby, Samia S. Abouelkheir, Hamdy A. Abo-Taleb, Nermeen A. El Sersy
Blue Economy
In terms of focus, promising results obtained from extensive investigations showed that the biodiversity of marine invertebrates has been documented. This poses the marine ecosystem as a hopeful resource in the discovery of novel compounds, with an ideal starting point in scaffolding additional screening of marine natural products (MNPs), especially to face the rise in the burden of diseases and treatment failure. A wide range of antimicrobial, antiviral, anticancer, anti-inflammatory, antiparasitic, neuroprotective, analgesic, antimalarial and other agents of marine origin have been pursued in the control and management of diseases. In the current review, we will focus on figuring out …
Ultradeformable Nanocarriers For Efficient Transdermal Drug Delivery, Hala N. Elshagea, Rana R. Makar, Alaa H. Salama, Nermeen A. Elkasabgy, Emad B. Basalious
Ultradeformable Nanocarriers For Efficient Transdermal Drug Delivery, Hala N. Elshagea, Rana R. Makar, Alaa H. Salama, Nermeen A. Elkasabgy, Emad B. Basalious
Bulletin of Faculty of Pharmacy Cairo University
Ultradeformable nanovesicles (UDVs) have recently become one of the favorable tools used for the transdermal delivery of drugs into deep skin layers, leading to enhanced bioavailability and therapeutic effect. UDV are capable of carrying hydrophilic, lipophilic or amphiphilic drugs bypassing the skin barriers. This mini review presents examples of UDV, their advantages, different mechanisms for UDV skin penetration, and some of the recent studies that proved the liability of using such carriers for better skin penetration. The applicability of using UDV for transdermal drug delivery has expanded such that marketed drug products were recently approved and launched indicating its superiority …
Cost-Variation Analysis Of Antihemorrhagic Drugs In The Egyptian Market, Michael A. Kaldas, Aya M. Abdel Magid, Samar F. Farid
Cost-Variation Analysis Of Antihemorrhagic Drugs In The Egyptian Market, Michael A. Kaldas, Aya M. Abdel Magid, Samar F. Farid
Bulletin of Faculty of Pharmacy Cairo University
Background: Cardiovascular diseases (CVDs) are considered the leading cause of death worldwide. An important category of the CVDs is the bleeding disorders. There is a significant variation in the drug products used in the treatment of hemorrhagic disorders in the Egyptian market. Therefore, our study aims to evaluate the cost variation of different brands of antihemorrhagic drugs in the Egyptian market. Methods: The study used an analytical method to obtain the different prices of the available antihemorrhagic drug products in the Egyptian market (in Egyptian Pound), from different drug categories considering all the concentrations available. Each generic name was checked …
Gc And Hptlc- Densitometric Methods For Simultaneous Determination Of Aspirin, Paracetamol, Caffeine Anhydrous, Dextromethorphan Hydrobromide And Chlorpheniramine Maleate: Method Validation And Application To Over The Counter Tablet, Lamia M. Abdel-Halim, Nesrin K. Ramadan, Mohamed K. Abd-El Rahman, Maha M. Galal
Gc And Hptlc- Densitometric Methods For Simultaneous Determination Of Aspirin, Paracetamol, Caffeine Anhydrous, Dextromethorphan Hydrobromide And Chlorpheniramine Maleate: Method Validation And Application To Over The Counter Tablet, Lamia M. Abdel-Halim, Nesrin K. Ramadan, Mohamed K. Abd-El Rahman, Maha M. Galal
Bulletin of Faculty of Pharmacy Cairo University
This study presents two validated chromatographic methods for determining aspirin, paracetamol, caffeine anhydrous, dextromethorphan hydrobromide, and chlorpheniramine maleate in Vegaskin-D® tablets. Method I used high performance thin layer liquid chromatography densitometric method (HPTLC-densitometric), using a stationary phase of silica gel 60 F254, and UV detection at 254.0 nm resulting in well-resolved, symmetrical, and sharp peaks. Method II used gas chromatography (GC) with a flame ionization detector. The results showed that the proposed methods can effectively be implemented for routine analysis and quality control of drugs in fixed-dose combination tablets. The GC method has an advantage over HPTLC- densitometric method due …
Spectrophotometric Resolution Methods For Determination Of Dimenhydrinate And Cinnarizine In Presence Of Their Toxic Impurities: Greenness, Environmental Sustainability And Blueness Assessment Tools, Eman M. Morgan, Yasmin M. Fayez, Shereen A. Boltia, Reem H. Obaydo, M. Abdelkawy, Hayam M. Lotfy
Spectrophotometric Resolution Methods For Determination Of Dimenhydrinate And Cinnarizine In Presence Of Their Toxic Impurities: Greenness, Environmental Sustainability And Blueness Assessment Tools, Eman M. Morgan, Yasmin M. Fayez, Shereen A. Boltia, Reem H. Obaydo, M. Abdelkawy, Hayam M. Lotfy
Bulletin of Faculty of Pharmacy Cairo University
Spectrophotometric analysis of the core drug while the coexistence of their toxic impurities is a vital analytical process. To date, there was no reported spectrophotometric method that have been reported for the simultaneous analysis of the two target drugs namely dimenhydrinate (DMH) and cinnarizine (CIN) in the presence of their most toxic impurities namely benzophenone (BZP) and 1- (diphenylmethyl)piperazine (DPP), respectively. In this study novel, green, accurate and timeless spectrophotometric analysis of a mixture of pharmaceutical drugs composed of DMH and CIN along with their toxic impurities BZP and DPP, respectively was successfully performed using smoothly applicable and costless spectrophotometric …
Outdoor Position Recovery From Heterogeneous Telco Cellular Data, Yige Zhang, Weixiong Rao, Kun Zhang, Lei Chen
Outdoor Position Recovery From Heterogeneous Telco Cellular Data, Yige Zhang, Weixiong Rao, Kun Zhang, Lei Chen
Machine Learning Faculty Publications
Recent years have witnessed unprecedented amounts of data generated by telecommunication (Telco) cellular networks. For example, measurement records (MRs) are generated to report the connection states between mobile devices and Telco networks, e.g., received signal strength. MR data have been widely used to localize outdoor mobile devices for human mobility analysis, urban planning, and traffic forecasting. Existing works using first-order sequence models such as the Hidden Markov Model (HMM) attempt to capture spatio-temporal locality in underlying mobility patterns for lower localization errors. The HMM approaches typically assume stable mobility patterns of the underlying mobile devices. Yet real MR datasets exhibit …
An Empirical Study Of The Impact Of The Euro On Cross-Country Diversification, Demissew D. Ejara, Kamal Upadhyaya
An Empirical Study Of The Impact Of The Euro On Cross-Country Diversification, Demissew D. Ejara, Kamal Upadhyaya
Finance Faculty Publications
Abstract The euro was launched, on 1 January 1999, as a common currency for members of the European Union that complied with the Maastricht Treaty. The Maastricht Treaty calls for the coordination of major macroeconomic policies, such as inflation, budget balance, public debt, and long-term interest rates. Theoretically, the coordination of these policy issues and the launch of a common currency will increase the degree of market integration among member countries. This paper empirically tests the impact of the euro on the degree of market integration by looking at the comovement of the European equity markets and a sample of …
Benign Acute Childhood Myositis In A Pediatric Patient Post Influenza B Infection, Michael C. Huzior, Brendan P. Chernicki, Lisa Nguyen, Bobby Kumar
Benign Acute Childhood Myositis In A Pediatric Patient Post Influenza B Infection, Michael C. Huzior, Brendan P. Chernicki, Lisa Nguyen, Bobby Kumar
HPD Articles
Benign acute childhood myositis (BACM) is a mild and self-limited sudden onset of lower extremity pain during or following recovery from a viral illness. It is characterized by difficulty walking due to severe bilateral calf pain, which usually resolves in three days. It is typically appreciated during times of large influenza outbreaks and epidemics. The most severe complication can be rhabdomyolysis without proper treatment and can lead to renal damage and potential renal failure. There are limited reported cases of BACM and therefore no clear guidelines in the treatment or management of the condition. This case is unique in the …
Prolonged Antibiotic Use In A Preclinical Model Of Gulf War Chronic Multisymptom-Illness Causes Renal Fibrosis-Like Pathology Via Increased Micro-Rna 21-Induced Pten Inhibition That Is Correlated With Low Host, Ayushi Trivedi, Dipro Bose, Punnag Saha, Subhajit Roy, Madhura More, Jonathan Skupsky, Nancy G. Klimas, Saurabh Chatterjee
Prolonged Antibiotic Use In A Preclinical Model Of Gulf War Chronic Multisymptom-Illness Causes Renal Fibrosis-Like Pathology Via Increased Micro-Rna 21-Induced Pten Inhibition That Is Correlated With Low Host, Ayushi Trivedi, Dipro Bose, Punnag Saha, Subhajit Roy, Madhura More, Jonathan Skupsky, Nancy G. Klimas, Saurabh Chatterjee
HPD Articles
Gulf War (GW) veterans show gastrointestinal disturbances and gut dysbiosis. Prolonged antibiotic treatments commonly employed in veterans, especially the use of fluoroquinolones and aminoglycosides, have also been associated with dysbiosis. This study investigates the effect of prolonged antibiotic exposure on risks of adverse renal pathology and its association with gut bacterial species abundance in underlying GWI and aims to uncover the molecular mechanisms leading to possible renal dysfunction with aging. Using a GWI mouse model, administration of a prolonged antibiotic regimen involving neomycin and enrofloxacin treatment for 5 months showed an exacerbated renal inflammation with increased NF-κB activation and pro-inflammatory …
In An Animal’S Shoes: Facing Animal Suffering As A Difficulty Of Reality, Konstantin Deininger
In An Animal’S Shoes: Facing Animal Suffering As A Difficulty Of Reality, Konstantin Deininger
Between the Species
This paper examines the challenges posed by confronting the topic of animal suffering in animal husbandry. The predominant positions within animal ethics mainly focus on the moral status of humans and animals, arguing that killing farm animals is morally wrong due to specifiable intrinsic properties that grant farm animals significant moral status. Such positions are derived from a detached perspective that advocates for rational consistency. This paper opposes this detached perspective. By drawing on Cora Diamond’s concept of a difficulty of reality, it contends that facing animal suffering, including changing one’s habits and attitudes towards this suffering, is instead best …
Measuring Moral Distress And Moral Injury: A Systematic Review And Content Analysis Of Existing Scales, Stephanie A. Houle, Natalie Ein, Julia Gervasio, Rachel A. Plouffe, Brett T. Litz, R. Nicholas Carleton, Kevin T. Hansen, Jenny J.W. Liu, Andrea R. Ashbaugh, Walter Callaghan, Megan M. Thompson, Bethany Easterbrook, Lorrraine Smith-Macdonald, Sara Rodrigues, Stéphanie A.H. Bélanger, Katherine Bright, Ruth A. Lanius, Clara Baker, William Younger, Suzette Bremault-Phillips, Anthony Nazarov
Measuring Moral Distress And Moral Injury: A Systematic Review And Content Analysis Of Existing Scales, Stephanie A. Houle, Natalie Ein, Julia Gervasio, Rachel A. Plouffe, Brett T. Litz, R. Nicholas Carleton, Kevin T. Hansen, Jenny J.W. Liu, Andrea R. Ashbaugh, Walter Callaghan, Megan M. Thompson, Bethany Easterbrook, Lorrraine Smith-Macdonald, Sara Rodrigues, Stéphanie A.H. Bélanger, Katherine Bright, Ruth A. Lanius, Clara Baker, William Younger, Suzette Bremault-Phillips, Anthony Nazarov
MacDonald Franklin OSI Research Centre
Background: Moral distress (MD) and moral injury (MI) are related constructs describing the negative consequences of morally challenging stressors. Despite growing support for the clinical relevance of these constructs, ongoing challenges regarding measurement quality risk limiting research and clinical advances. This study summarizes the nature, quality, and utility of existing MD and MI scales, and provides recommendations for future use. Method: We identified psychometric studies describing the development or validation of MD or MI scales and extracted information on methodological and psychometric qualities. Content analyses identified specific outcomes measured by each scale. Results: We reviewed 77 studies representing 42 unique …
Teaching Hispanic Culture, Diversity, And Tolerance Through Hispanic Dances And Music: Two Approaches For Flamenco & Caribbean Dances, Chita Espino-Bravo Ph.D., D. Nicole English
Teaching Hispanic Culture, Diversity, And Tolerance Through Hispanic Dances And Music: Two Approaches For Flamenco & Caribbean Dances, Chita Espino-Bravo Ph.D., D. Nicole English
Modern Languages Faculty Publications
A Sociology Approach: Dance can be a useful tool for teaching students about culture and community. Through the language of Dance and Music (Caribbean Dance), context is given to social facts, which engages and informs students about such social issues as history, Colonialism,social class, gender, race/ethnicity, and social justice. The added bonus of using Dance as a lens is that it involves active, embodied learning (Dewey, English, Mead), making the material more memorable, meaningful, and relevant to the learner. A Communicative Approach (Task-based Learning Activity) & Language for Specific Purposes:Task-Based Language Teaching (TBLT) is a derivative of the Communicative Approach …
Case Report And Literature Review Of An Atypical Polymyalgia Rheumatica And Its Management, Saad Bilal Ahmed, Saara Ahmad, Hanmei Pan
Case Report And Literature Review Of An Atypical Polymyalgia Rheumatica And Its Management, Saad Bilal Ahmed, Saara Ahmad, Hanmei Pan
Department of Biological & Biomedical Sciences
Polymyalgia rheumatica (PMR) is a systemic inflammatory disease of the elderly population that increases in incidence as age advances. It is characterised by the sudden or sub-acute onset of symptoms affecting the shoulder and pelvic girdles, often accompanied by constitutional symptoms. Due to the lack of consensual diagnostic criteria and specific laboratory or radiological investigations for PMR, its diagnosis can be very challenging, particularly because it can be mimicked or masked by other geriatric syndromes. PMR responds well to glucocorticoid treatment, but if left untreated, can lead to morbidity and poor quality of life. We present the case of an …
Structural Basis For Dna Proofreading, Gina Buchel, Ashok Nayak, Karl Herbine, Azadeh Sarfallah, Viktoriia Sokolova, Angelica Zamudio-Ochoa, Dmitry Temiakov
Structural Basis For Dna Proofreading, Gina Buchel, Ashok Nayak, Karl Herbine, Azadeh Sarfallah, Viktoriia Sokolova, Angelica Zamudio-Ochoa, Dmitry Temiakov
Department of Biochemistry and Molecular Biology Faculty Papers
DNA polymerase (DNAP) can correct errors in DNA during replication by proofreading, a process critical for cell viability. However, the mechanism by which an erroneously incorporated base translocates from the polymerase to the exonuclease site and the corrected DNA terminus returns has remained elusive. Here, we present an ensemble of nine high-resolution structures representing human mitochondrial DNA polymerase Gamma, Polγ, captured during consecutive proofreading steps. The structures reveal key events, including mismatched base recognition, its dissociation from the polymerase site, forward translocation of DNAP, alterations in DNA trajectory, repositioning and refolding of elements for primer separation, DNAP backtracking, and displacement …
Whole-Genome Long-Read Sequencing Downsampling And Its Effect On Variant-Calling Precision And Recall., William T Harvey, Peter Ebert, Jana Ebler, Peter A Audano, Katherine M Munson, Kendra Hoekzema, David Porubsky, Christine R Beck, Tobias Marschall, Kiran Garimella, Evan E Eichler
Whole-Genome Long-Read Sequencing Downsampling And Its Effect On Variant-Calling Precision And Recall., William T Harvey, Peter Ebert, Jana Ebler, Peter A Audano, Katherine M Munson, Kendra Hoekzema, David Porubsky, Christine R Beck, Tobias Marschall, Kiran Garimella, Evan E Eichler
Faculty Research 2024
Advances in long-read sequencing (LRS) technologies continue to make whole-genome sequencing more complete, affordable, and accurate. LRS provides significant advantages over short-read sequencing approaches, including phased de novo genome assembly, access to previously excluded genomic regions, and discovery of more complex structural variants (SVs) associated with disease. Limitations remain with respect to cost, scalability, and platform-dependent read accuracy and the tradeoffs between sequence coverage and sensitivity of variant discovery are important experimental considerations for the application of LRS. We compare the genetic variant-calling precision and recall of Oxford Nanopore Technologies (ONT) and Pacific Biosciences (PacBio) HiFi platforms over a range …
Thrombotic And Hemorrhagic Complications Following Left Ventricular Assist Device Placement: An Emphasis On Gastrointestinal Bleeding, Stroke, And Pump Thrombosis, Joseph Phan, Kareem Elgendi, Masi Javeed, Juan M. Aranda, Mustafa M. Ahmed, Juan Vilaro, Mohammad Al-Ani, Alex M. Parker
Thrombotic And Hemorrhagic Complications Following Left Ventricular Assist Device Placement: An Emphasis On Gastrointestinal Bleeding, Stroke, And Pump Thrombosis, Joseph Phan, Kareem Elgendi, Masi Javeed, Juan M. Aranda, Mustafa M. Ahmed, Juan Vilaro, Mohammad Al-Ani, Alex M. Parker
HPD Articles
The left ventricular assist device (LVAD) is a mechanical circulatory support device that supports the heart failure patient as a bridge to transplant (BTT) or as a destination therapy for those who have other medical comorbidities or complications that disqualify them from meeting transplant criteria. In patients with severe heart failure, LVAD use has extended survival and improved signs and symptoms of cardiac congestion and low cardiac output, such as dyspnea, fatigue, and exercise intolerance. However, these devices are associated with specific hematologic and thrombotic complications. In this manuscript, we review the common hematologic complications of LVADs.
Nativities On Demand!, Michele Jennings
Nativities On Demand!, Michele Jennings
Marian Library Blog Archive
Live too far to visit this year’s crèche exhibit? With the Nativities and the Natural World audio tour, you can still enjoy it.
University Studies Annual Assessment 2022-2023, Portland State University. University Studies Program
University Studies Annual Assessment 2022-2023, Portland State University. University Studies Program
University Studies Annual Assessment Reports
Annual in-depth examination and assessment of Portland State University's general education model, the University Studies Program. The tools and methods used to assess student learning are faculty driven and developed.