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Evaluation Of Morphologic And Morphometric Characteristics Of The Mental Foramen And Anterior Loop In A Turkish Subpopulation Using Cone Beam Computed Tomography, Fatma Büşra Doğan, Faruk Akgünlü

Journal of Dentistry Indonesia

Objective: Before a surgical intervention in the mandibular interforaminal area, it is important to have a full understanding of the anatomy of the mandibular anterior segment. The evaluation of anatomical structures, variations and pathologies is performed with radiological imaging methods. Today, cone beam computed tomography (CBCT) is an imaging method which offers all the features necessary for this. In addition to its importance in surgical applications, it is also valuable in terms of anatomical studies thanks to the reliability of its measurements and the fact that it allows for a three-dimensional evaluation. The mental foramen and anterior loop are …

Prevalence And Clinical Characteristics Of Temporomandibular Disorders In Adults: An Epidemiological Study In The Mediterranean Region Of Türkiye, Esra Yavuz, Selmi Yardimci, Humeyra Tercanli

Journal of Dentistry Indonesia

The prevalence and clinical characteristics of temporomandibular disorders (TMD) in the Mediterranean region of Türkiye have not yet been thoroughly investigated. Objective: This study aimed to determine the prevalence and severity of TMD in a sample of the population in this region and to characterize the clinical findings related to TMD. Methods: Four hundred and one participants were included in this study. “Presence of TMD” in the participants was evaluated using the Fonseca Anamnestic Index. Through clinical examination, the findings in the participants were classified as limited mouth opening, deviation, temporomandibular joint (TMJ) sounds, TMJ pain, and muscle …

Contents Vol 30 No 3 2023, Dr. Yuniardini Septorini Septorini Wimardhani

Journal of Dentistry Indonesia

This is the content of Vol. 30 number 3 2023.

Case Report And X-Ray Microtomography And Scanning Electron Microscopy Analysis Of Teeth With Hypocalcified Amelogenesis Imperfecta, Rodrigo W. Marinoni, Thiago G. Silva, Leonardo S. Benato, Anelize M B Rumbelsperger, Antonio Adilson Soares De Lima

Journal of Dentistry Indonesia

Amelogenesis imperfecta (AI) is a genetic disease characterized by producing morphological and structural changes in tooth enamel. Objective: To highlight the morphological changes observed in teeth with hypocalcified AI based on scanning electron microscopy and microtomography analysis. Case report: An adult male had teeth seriously compromised by hypocalcified AI. The treatment plan involved removal of third molars followed by restorative and prosthetic treatment. After extraction, the teeth were analyzed by SEM and X-ray microtomography (microCT). Teeth with AI revealed the presence of microfractures arranged from the outer surface to the center of the enamel. Microfractures had a cracked or “cracked …

Surface Roughness Of Restorative Materials After Simulated Toothbrushing With Toothpastes Containing Theobromine And Arginine: An In Vitro Study, Fikri Öcal, Burak Dayi, Zeynep Küçükakçalı

Journal of Dentistry Indonesia

Objective: This study examined the effect of toothpastes containing theobromine and arginine on the roughness changes of microhybrid composite, nanohybrid composite, and giomer restorative materials. Methods: A total of 90 disc-shaped specimens were prepared using microhybrid composite (Arabesk-Ara), nanohybrid composite (Herculite-Her), and giomer (Beautifil II-Gio). The samples were divided into 3 subgroups (n = 10), and initial surface roughness was evaluated with a mechanical profilometer and scanning electron microscopy (SEM). All samples were then subjected to a 1-year brushing simulation via a toothbrushing simulator using toothpastes containing theobromine (Theodent Classic, Theodent) or arginine (Colgate PRO-Relief, Colgate Palmolive); a …

Comparison And Assessment Of Design, Handling Characteristics, And Efficacy Of Hand Instruments In Calculus Removal, Mohan Kumar Pasupuleti, Krishna Ganesh, Gautami S Penmetsa, Boddeda Anusha, Haripriya Narukurthi, Kommina Mouna Sahith

Journal of Dentistry Indonesia

Objective: primary objective of periodontal therapy is to remove supra and subgingival deposits from the tooth surface to stop disease progression. The purpose of the study is to address the instrument selection and its efficacy in calculus removal. Methods: A total of 50 subjects who fulfilled the criteria were included in the study. Participants were subjected to a complete periodontal examination, and the responses from 50 dental house surgeons were compared based on the instrument design, handling characteristics, and efficacy of calculus removal by using two sets of instruments. Results: The LM instrument was rated as best …

Factors Affecting The Preference Of Orthodontic Appliances Among Undergraduate Students In West Jakarta, Joko Kusnoto, Lia H. Andayani, Budi Kusnoto

Journal of Dentistry Indonesia

Malocclusion’s negative impact is not only limited to dentofacial appearance but also related to quality of life. Nowadays, orthodontic treatment can be done using conventional fixed appliances, or removable appliances called clear aligners. The preference for orthodontic appliances can be affected by several factors, including patient characteristics, self-perception, psychosocial, and oral-disorder factors. Objective: This study aims to evaluate the factors affecting the preference for orthodontic appliances among undergraduate students in West Jakarta. Methods: In this cross-sectional study, 244 undergraduate students were retrieved by purposive sampling from 7 universities located in West Jakarta. A self-administered questionnaire was used to …

Elastic Recovery Properties Of Alginate Impression Materials Based On Red Algae Kappaphycus Alvarezii, Didin Erma Indahyani, Izzata Barid, Nafisah Nafisah, Depi Praharani, Agus Sumono, Niken Probosari, Sulistiyani Sulistiyani

Journal of Dentistry Indonesia

Alginate impression materials in dentistry are used to form details of the oral cavity organs. The alginate content in the impression material functions to form a gel. One source of alginate is algae. Objective: This study aims to determine the recovery elasticity and setting time of alginate impression materials made from red algae K. alvarezii. Methods: The sodium alginate in the composition of this alginate impression material was extracted from red algae K. alvarezii. The alginate impression material was tested for setting time and recovery elasticity and compared with commercial impression material (Hygedent®). Results: The elastic …

Enigmatic Cervicofacial Actinomycosis Post Radiotherapy - A Case Report, Amanda Phoon Nguyen

Journal of Dentistry Indonesia

Although thought to be uncommon, it is believed that cervicofacial actinomycosis is underreported due to frequent misdiagnosis. It has been called the “most misdiagnosed disease by experienced clinicians”. A wide range of dental procedures or trauma, including tooth eruption, may precipitate actinomycosis by enabling microorganisms to penetrate the deeper tissue layers via an entry point. This infective disease is significant due to its potentially aggressive and locally destructive nature. This case describes a patient diagnosed with cervicofacial actinomycosis. Her history prior to this was significant for proliferative verrucous leukoplakia, and T4aN0M0 (AJCC 7th Edition) squamous cell carcinoma of the right …

Critical Links And Development Trends Of Research On Active Tectonics, Yuan Daoyang, Wang Youlin, Li Shuwu, Wang Wanhe, Li Linyuan, Zou Xiaobo, Wen Yameng

Coal Geology & Exploration

Following a brief introduction of the general characteristics of active tectonics in China, this study analyzed two new features of large earthquakes with M_s ≥ 7 that have struck continental China since the beginning of the 21st century: (1) Large earthquakes occur primarily in clusters along the boundary fault zone of the Bayanhar active tectonic block—part of the Qinghai-Tibet ateau active tectonic block. (2) Reverse fault-fold earthquakes have occurred multiple times within active basins or at basin-mountain boundaries. In response to the new seismic activity features and the new demand for disaster prevention and mitigation of engineering construction and …

New Evidence For Holocene Activity Of The Northern Segment Of The Puqian-Qinglan Fault In Northern Hainan Province, Liu Huaguo, Li Feng, Jia Qichao, Wang Zhicheng, Zhang Pan, Lin Zhen, Zhang Jiehan, Shi Chunhua, Zhang Yanbo, Jia Wei, Li Changlong

Coal Geology & Exploration

The Puqian-Qinglan fault, located in northern Hainan Province, is closely related to the judgment of the seismogenic structure of the Qiongshan M7½ earthquake in 1605. To accurately determine the latest activity characteristics of this fault, this study, adopting artificial shallow seismic exploration with large-tonnage seismic sources combined with small-spacing cross-well stratigraphic correlation, investigated the sedimentary geological conditions of the Quaternary basalt cover and significantly thick marine sand layers in northern Hainan Province through exploration at Qishantou and Dongzhai villages in the Sanjiang Town, Jiangdong New Area, Haikou. Key results are as follows: (1) the Puqian-Qinglan fault dislocates multiple marker …

Activity Of The Liyang-Nandu Fault In Southern Jiangsu, Zhang Shuo, Zhang Ping, Chen Huogen, Xu Shugang, Gong Xulong, Xu Hangang, Li Limei, Feng Wenli, He Zongnan

Coal Geology & Exploration

Located in the central part of the Sunan Modernization Construction Demonstration Area—one of the areas with the densest population and urban areas and the most developed economy in China, the Liyang-Nandu fault is an important concealed fault with a nearly E-W strike in the Yangtze River Delta in eastern China. This fault serves as an important regional geomorphic and neotectonic boundary. However, there is a lack of systematic research on this fault, and its latest activity era is yet to be ascertained. Using seismic exploration P-waves and S-waves and cross-well stratigraphic correlation, this study investigated the spatial distribution and Quaternary …

Application Of High-Precision Lidar Technology In Research On Active Fault-Induced Offset Geomorphic Features - A Case Study Of The Juxian-Tancheng Segment Of The Yishu Fault Zone, Yang Bin, Wang Hualin, Wu Hongbin, Ge Fugang, Zou Hao, Su Sili

Coal Geology & Exploration

The Tancheng-Lujiang fault zone (also referred to as the TanLu fault zone), one of the most significant large-scale active faults in eastern China, has great seismogenic potential while passing through several cities with the activities and accumulation of human beings. To investigate the geometric distribution and activity characteristics of the TanLu fault zone, this study focused on the Juxian-Tancheng segment of the Yishu fault zone—a part of the TanLu fault zone. Given the vegetation coverage in eastern China, airborne light detection and ranging (LiDAR) and terrestrial laser scanning were employed to collect high-precision topographic data of the Zuoshan (Yibujian), Zhonghuashan, …

Theory And Application Of Setback Distance From Active Faults, Wei Leiming, Xu Xiwei, Li Feng, Cao Jun, Ren Junjie, Cheng Jia, Zhang Xianbing, Jia Qichao, Chen Guihua, Wu Xiyan

Coal Geology & Exploration

Determining setbacks from active faults is the “last 1 km” from active fault surveys to their application to seismic disaster mitigation. It is also a technique for blocking the risk sources of earthquake-induced chains of geologic hazards. Field investigations and experimental studies have demonstrated that buildings and structures can be free from catastrophic destruction caused by coseismic ruptures and offset of active faults provided they are kept at a certain finite distance from the active fault traces. Therefore, determining setbacks from active faults serves as an ultimate goal of the surveys and precise localization of active faults. Based on the …

Revealing The Upper Crustal Structure In The Fujian Region Using Deep Seismic Profiling, Li Pei, Ren Congrong, Li Haiyan, Wang Shanxiong

Coal Geology & Exploration

The Fujian region, located along the southeastern margin of the Chinese continent, constitutes an active tectonic belt along the coastal area in southeast China, with complex formation and evolution histories. To understand the characteristics of upper crustal structures and basement structures in the Fujian, this study collected the Pg travel time data from four NE-trending deep seismic sounding (DSS) survey lines in the region. Employing finite-difference tomography, this study obtained the fine-scale velocity structure of the upper crust along the four profiles, revealing the lateral variations in the upper crustal velocity structure, basement structures, and shallow fault characteristics in the …

Analogue Modeling Of Love-Type Channel Waves And Their Response To Faults, Liu Qiang, Hu Jiwu, Wang Pan, Shi Xianxin, Jia Qian

Coal Geology & Exploration

Owing to its high resolution and low energy attenuation, channel wave-based seismic exploration has been widely applied in the geophysical prospecting of hidden disaster-causing factors in underground coal mines. However, its accuracy fails to meet the requirements of intelligent mine mining presently. At present, the analogue modeling of channel waves mostly focuses on Rayleigh-type channel waves using 2D models, leading to a lack of research on Love-type channel waves. To explore the propagation law of Love-type channel waves, this study investigated the waves in the 3D analogue modeling of channel waves. Firstly, the wave and particle vibration characteristics of Love-type …

Multipoint Sources-Based High-Resolution Electrical Detection Of The Water-Rich Areas Near Mining Faces Of Coal Mine Roadways, Wu Rongxin, Xu Hui

Coal Geology & Exploration

To accurately explore the spatial distribution of water-rich areas near mining faces of mine roadways, this study proposed a multipoint sources-based high-resolution electrical detection technology. A multi-channel electrode observation system was arranged behind a roadway mining face, with electrodes at a distance of 1/4 measuring lines behind the mining face as point source electrodes sequentially. Data were collected using a monopole-dipole device, with the obtained apparent resistivity considered the sounding data of multipoint sources-based electrical detection. The images of multipoint sources-based electrical sounding allow for quickly determining the presence of water-rich areas and their locations relative to the mining faces …

Coal-Based Solid Waste From The Panyi Mine In The Huainan Mining Area: Fine-Scale Chemical Structure And Ecological Risk Assessment Of Heavy Metals, Yin Wenwen, Zhang Liqun, Ding Dan, Shan Shifeng, Chen Yongchun, An Shikai, Zheng Liugen

Coal Geology & Exploration

The utilization of clean coal-based solid waste is a pressing issue in the ecological construction of mining areas. To address this issue, the key is to ascertain the structures and morphology of heavy metals in coal-based solid waste. This study investigated the coal gangue and fly ash samples from the Panyi Mine in the Huainan mining area, Anhui Province. First, this study characterized the coal-based solid waste using microanalysis methods, such as X-ray fluorescence spectrometry (XRF), X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR). Then, it examined the fine-scale chemical structure and heavy metal dissemination …

Current States , Prediction And Prevention Suggestions For Water Hazard Accidents In China’S Coal Mines, Sun Wenjie, Li Wenjie, Ning Dianyan, Ren Lingfeng

Coal Geology & Exploration

At present, the pattern of coal resource development in China has changed, but the water hazard accidents that restrict the safety production of coal mine still occur from time to time. In order to explore the characteristics and laws of water hazard accidents in coal mines in China and scientifically study and judge the evolution trend of water hazard accidents, study was performed in terms of the year, region, accident level and influencing factors of water hazard accidents, with the nationwide water hazard accidents from 2001 to 2022 as the statistical objects. Meanwhile, the Long Short-Term Memory (LSTM) model was …

Vascular Injury Risk Stratification For Lateral Lumbar Interbody Fusion (Llif) At L4-L5: A Morphometric Study Using Magnetic Resonance Imaging, Takashi Hirase, Aaron J Greenberg, Catherine G Ambrose, Derek T Bernstein, Jeffrey J Ratusznik, Rex A W Marco

Faculty, Staff and Student Publications

BACKGROUND: Proper vascular injury risk stratification (VIRS) methods for L4-L5 lateral lumbar interbody fusion (LLIF) surgery have not been well-described. The objective of this study was to propose a novel VIRS method for L4-L5 LLIF surgery via the transpsoas approach.

METHODS: Axial magnetic resonance imaging (MRI) of adult patients were obtained and analyzed. The VIRS scores were assessed using anterior disc line to posterior vessel wall distance, the disc vessel angle (DVA), and the disc edge to vessel distance at the level of L4-L5 disc space.

RESULTS: Ninety-one consecutive adult patients were included in the study. The right common iliac …

Mechanisms Linking Proteins And Structural Brain Integrity To Biological Markers Of Alzheimer’S Disease, Adam Turnbull, Yejin Kim, Kai Zhang, Tianrui Mao, Xiaoqian Jiang, Victor Henderson, Zihuai He, Feng Vankee Vankee Lin

Faculty, Staff and Student Publications

Background

Medial temporal lobe (MTL) networks, including posterior-medial (PM) and anterior-temporal (AT) subnetworks, are early affected by Alzheimer’s disease (AD) pathologies (tau, neurodegeneration) and are critical for memory, which declines in AD. The biological pathways linking AD pathology, changes in MTL-AT-PM structural connectivity (SC), and cognitive decline, are unknown. Plasma protein levels reflect those in the cerebrospinal fluid, providing a low-invasive potential means of understanding molecular brain changes that occur in AD. These measures may help explain how AD pathology, MTL-AT-PM SC, and cognitive decline are linked at the molecular level. We used predefined aging-related plasma proteins from a meta-analysis …

Citizens Apart? Representing Post-Brexit Youth Politics In The Uk Media, M Holton, J Lee, S Beech, S Mcdowell

School of Geography, Earth and Environmental Sciences

In 2016, the UK voted to leave the European Union (EU). This outcome was not only unexpected but also had clear geographical and age-bound divisions. While people over the age of 65 tended to vote to leave, younger voters were more likely to vote to remain a part of the EU. Reflecting on 7 years of journalism, this paper explores the ways in which young people have been represented by the news media with regards to the issue of Brexit. It analyses a database of 700 news media articles published from 2016 to 2022 across the UK, equating to 100 …

Preliminary Neurocognitive Finding From A Multi-Site Study Investing Long-Term Neurological Impact Of Covid-19 Using Ultra-High Field 7 Tesla Mri-Based Neuroimaging, Jonika D. Tannous, Farhaan S. Vahidy, Riddhi Patira, Alison M. Luckey, Mitzi M. Gonzales, Akram A. Hosseini, Timothy D. Girard, Tamer Ibrahim, Heidi I.L. Jacobs, Valentina R. Garbarino

School of Medicine Publications

Background: Globally, over six hundred million cases of SARS-CoV-2 have been confirmed. As the number of individuals in recovery rises, examining long-term neurological effects, including cognitive impairment and cerebral microstructural and microvascular changes, has become paramount., We present preliminary cognitive findings from an ongoing multi-site study investigating the long-term neurological impacts of COVID-19 using 7 Tesla MRI-based neuroimaging.

Methods: Across 3 US and 1 UK sites, we identified adult (>=18) COVID-19 survivors (CS) and healthy controls (HC) without significant pre-existing medical, neurological, or psychiatric illness. Using the National Alzheimer’s Coordinating Center (NACC) Uniform Data Set (UDS-3) battery …

Hippocampal Subfield Volumes In Covid-19: A Preliminary Multicenter Study Using 7t Mri, Salem Alkateeb, Jinghang Li, Gabriel A. De Erausquin, Monica Goss, Jayandra J. Himali, Karl Li, Rejani R. Nair, Beth E. Snitz, Gowland Penny, Valentina R. Garbarino

School of Medicine Publications

Background: Hippocampal formation atrophy is a well-established imaging biomarker of several neurological diseases, including Alzheimer's disease, temporal lobe epilepsy, and schizophrenia. The hippocampus is divided into subfields that have different functions and vary in sensitivity to different diseases. This study investigates the potential interaction between COVID-19 and the various hippocampus subfields, which may shed light on the long-term neurological consequences of the virus.

Method: We obtained high-resolution T1-weighted (T1w) and T2-weighted (T2w) MRI images using 7T scanners located at three sites in two countries: Pittsburgh (n=14) and Texas (San Antonio and Houston) (n=40) in the USA, and Nottingham, …

Covid-19 May Have A Detrimental Impact On Sensorimotor Function, Monica Goss, Rebecca Bernal, Vibhuti N. Patel, Karl Li, Valentina R. Garbarino, Rejani R. Nair, Heather Snyder, Gabriel A. De Erausquin, Mary Ganguli, Beth E. Snitz, Timothy D. Girard

School of Medicine Publications

Background: The long-term impact of COVID-19 on global health is still unknown. Sensorimotor biomarkers may be promising indicators of lasting effects of COVID-19. Although normal aging may cause changes in sensorimotor function, more severe changes may indicate the subsequent impacts of COVID-19 on brain health. The objective of this study was to investigate the association between COVID-19 and sensorimotor markers (grip strength, gait, and smell) in the 7T neuroCOVID consortium, which is comprised of 5 sites: The University of Texas Health Science Center at San Antonio, Houston Methodist Research Institute, The University of Pittsburgh, Massachusetts General Hospital, and Nottingham University …

Elevated Amyloid-Β And Tau Levels In The Brain Are Associated With A Reduced Abundance Of Neuroprotective Gut Bacteria, Yannick Joel Wadop Ngouongo, Jazmyn A. S. Muhammad, Tiffany F. Kautz, Claudia Satizabal, Jayandra Jung Himali, Sudha Seshadri, Bernard Fongang

School of Medicine Publications

Background: Recent research suggests that differences in the gut microbiome composition may contribute to the pathogenesis of neurological disorders, including Alzheimer's disease (AD). Animal studies have shown that fecal microbiota transplantation reduces amyloid plaques in mouse AD models. However, whether the buildup of Aβ and tau deposits in the brain are associated with shifts in the human gut microbiota composition is understudied.

Method: We used stool specimens and neuropathological measures from 140 middle-aged individuals (Table 1: mean age 56, 54% Female) from the Framingham Heart Study (FHS) to assess the link between the gut microbiome composition and Aβ Positron …

An Innovative Model Using Promotores Or Community Health Workers For Home Based Dementia Care, Neela K. Patel, Cynthia De La Garza- Parker, Angelica Davila, Noe Garza, Monica Goss, Claudia L. Satizabal, Gabriel A. De Erausquin, Gladys E. Maestre, Sudha Seshadri

School of Medicine Publications

Background: Health disparities and issues with trust building and relationship building are prominent in Hispanic and underserved populations in south Texas. Community health workers can play a bridging role with underserved communities and may be essential in improving the quality and value of health care. The Texas Health and Human Services Commission certifies the training Community Health Workers under the label of “promotores”.

Method: Community health workers were integrated into the primary health care team to serve as a bridge between patient/caregiver dyads and the health care team.

Result: Community health workers (CHWs) connected patients to social determinants …

Dementia And Stroke Risk Associated With Brain Artery Luminal Diameters, Jesus D. Melgarejo, Kursat Gurel, Minghua Liu, Bonnie Levin, Mitchell S.V. Elkind, M. Kamran Ikram, M. Arfan Ikram, Fabrice Crivello, Christophe Tzourio, Zhen-Yu Zhang

School of Medicine Publications

Background: It is unclear whether brain artery diameters measured on conventional T2-weighted brain MRI images relate to dementia and stroke outcomes across distinct populations. We aimed this study to evaluate the association of T2-weighted brain artery luminal diameters with dementia and stroke in three distinct population‑based studies.

Methods: Three longitudinal population-based studies with 8420 adults >40 years old (Northern Manhattan Study [NOMAS] from the United States, and the Rotterdam Study [RS], from the Netherlands, and Three-City, from France) with brain MRI scans obtained between 1999 and 2015. The median follow-up time for clinical events ranged between 7 and …

Cognitive Sequealae Of Covid-19 Is Not Predicted By Sars-Cov-2 Variants, Gabriel A. De Erausquin, Jorge Igor Zwir, Heather Snyder, Gabriela Gonzalez-Aleman, Hernan P. Zamponi, Mariana Figueredo-Aguiar, Emiliano Fumagalli, John Blangero, Agustín Yécora,, Fabiana Vaca, Gabriela Kukoc

School of Medicine Publications

Background: The long term sequelae of COVID-19 in older adults are only beginning to be clarified, and its predictors and underlying molecular mechanisms may shed light on the relationship between viral infections and Alzheimer's disease and related dementia.

Method: A prospective cohort of 874 older adult Amerindians from Argentina with COVID-19 illness confirmed by PCR of nasal swabs as well as controls, was established during the first year of the COVID-19 pandemic. We obtained data on the severity of the acute illness, as well as extensive neuropsychiatric and cognitive assessments, neurological exams (including quantitative hyposmia/anosmia), plasma for biomarkers and preliminary …

Exploration Of The Tumorigenic, Metabolic, And Cognitive Consequences Of Tau Protein Removal, Jennifer M. Erichsen, Valentina R. Garbarino, Anna Rodriguez, Jillian K. Lee, Justin C. Shayne, Timothy C. Orr, Miranda E. Orr

School of Medicine Publications

Background: Tau accumulation causes tauopathies and drives cellular senescence, which can lead to inflammation, neurodegeneration, and cognitive impairment. The association between intracellular tau deposition and pathogenesis has prompted therapeutic strategies that reduce tau expression. However, tau is also critical in microtubule stabilization, synaptic plasticity, and maintaining DNA integrity. We investigated the impact of tau removal on brain cell senescence and associated neurocognitive behaviors in aged tau knockout (Mapt^0/0) and wild type control (Mapt^+/+) mice. We also assessed physical, metabolic, histological, and biochemical outcomes in Mapt^0/0 and Mapt^+/+ mice and in response to …