Digital Commons Network^™

Numerical Simulation Of Factors Affecting Flow Characteristics Of Double-Circular-Arc Gear Pump, Huang Cheng, Xu Kai, Wei Zhibo, Li Geqiang

Food and Machinery

Objective: Analyzed the influencing factors of the internal flow field pulsation characteristics of the new double circular arc gear pump, and adopt reasonable parameters to improve the output efficiency of the gear pump. Methods: The two-dimensional flow field simulation model of the gear pump was established, and the computational fluid dynamics software Fluent was used for simulation analysis to study the influence of different tip clearance, different gear eccentricity, load and speed on the instantaneous flow, flow pulsation and flow field characteristics of the oil outlet of the gear pump. Results: As the tooth tip clearance increased, the outlet flow …

Meishan Nuo Culture-Based Design And Application Of A Public Brand For Local Specialty Foods From Xinhua, Hunan, Tong Ling

Food and Machinery

In this review, the Meishan culture was investigated, and the Meishan Nuo facial makeup culture was found to be a unique cultural form predominantly native with a diverse coexistence. The distinctive artistic features and cultural connotations of this culture were highlighted. The cultural elements of the primitive, exaggerated, and humorous artistic design techniques were incorporated into the design of the public brand "Meishan Hui" for the local specialty foods in Xinhua. The brand design strategy, from visual to connotative expression, was analyzed by investigating the application of packaging of various local specialty food in Xinhua through case studies, and the …

Progress In The Effect Of Oligosaccharide Modification On Gelability Of Egg White Protein, Zhang Gensheng, Su Wenwen, Xu Guiyang, Su Lirui, Fei Yingmin

Food and Machinery

Egg white protein is a high-quality protein with high nutritional value and a variety of functional properties. The oligosaccharides can be covalently bound to the egg white protein through the glycosylation reaction, and the functional properties of the conjugates were improved compared with the natural egg white protein. In this review, the gel mechanism of oligosaccharide-egg white protein conjugates was reviewed, and the influencing factors of oligosaccharide-modified egg albumin gels were discussed. Moreover, effects of oligosaccharides on the functional properties of egg albumins were summarized, and the processing and application of oligosaccharide-modified egg albumin were prospected.

Isolation And Characterization Of Microbes From Agricultural Fields And Their Evaluation For The Control Of Plant Pests, Hira Liaqat Ali, Sumaira Mazhar, Afeefa Chaudhry

Journal of Bioresource Management

Plant diseases due to pests cause huge loss to crop fields every year. For the control of plant pest, pesticides are under use. Fusarium wilt is caused by phytopathogen Fusarium oxysporum. More than 100 species were affected due to this disease caused by this virus. Fungi also affect onion plant crop yield every year, when chemical pesticides are applied to onion crop field. It will increase the cost of onion production and it is also dangerous for the environment and living organism other than the targeted pests. A number of microorganisms like fungi, bacteria and nematode are currently being …

Managing Protected Areas: People And Places, Niall Finneran, Denise Hewlett, Richard Clarke, Richard Gunton, Debra Gray, Ainara Terradillos, Danny Byrne, Sheela Agarwal

Plymouth Business School

This open access book brings together 16 specially commissioned chapters drawn from a range of different professional-practitioner and academic global perspectives on the importance of the relationship between people and green and blue spaces. It focuses on issues surrounding the importance of natural environments on public health and wellbeing, and the environmental, cultural, and social importance of green and blue spaces that can result through responsible and sustainable adaptive management processes. It explores how the Covid-19 pandemic forced reconsiderations of our relationship with these natural spaces and highlights the important impact of the pace of climate change. While not pretending …

Engineered Adoptive T-Cell Therapies For Breast Cancer: Current Progress, Challenges, And Potential, Diego F Chamorro, Lauren K Somes, Valentina Hoyos

Faculty, Staff and Students Publications

Breast cancer remains a significant health challenge, and novel treatment approaches are critically needed. This review presents an in-depth analysis of engineered adoptive T-cell therapies (E-ACTs), an innovative frontier in cancer immunotherapy, focusing on their application in breast cancer. We explore the evolving landscape of chimeric antigen receptor (CAR) and T-cell receptor (TCR) T-cell therapies, highlighting their potential and challenges in targeting breast cancer. The review addresses key obstacles such as target antigen selection, the complex breast cancer tumor microenvironment, and the persistence of engineered T-cells. We discuss the advances in overcoming these barriers, including strategies to enhance T-cell efficacy. …

Critical Links And Development Trends Of Research On Active Tectonics, Yuan Daoyang, Wang Youlin, Li Shuwu, Wang Wanhe, Li Linyuan, Zou Xiaobo, Wen Yameng

Coal Geology & Exploration

Following a brief introduction of the general characteristics of active tectonics in China, this study analyzed two new features of large earthquakes with M_s ≥ 7 that have struck continental China since the beginning of the 21st century: (1) Large earthquakes occur primarily in clusters along the boundary fault zone of the Bayanhar active tectonic block—part of the Qinghai-Tibet ateau active tectonic block. (2) Reverse fault-fold earthquakes have occurred multiple times within active basins or at basin-mountain boundaries. In response to the new seismic activity features and the new demand for disaster prevention and mitigation of engineering construction and …

Masculine Ideals And Health In Older Men: Findings From The Wisconsin Longitudinal Study, Shane D. Burns, Patricia Drentea

APC Fund

How do older men’s masculine ideals affect their health? Are masculine activities involved in this relationship? Masculine identity upholds beliefs about masculine enactment. These beliefs can be detrimental to men and can lead to behaviors that can put undue stress on them. We examine how masculine ideals are associated with health and depressive symptomatology in older men. We used 2011 data from the Wisconsin Longitudinal Study (n = 2,594) to investigate how masculine ideals inform older men’s health and how participation in masculine activities might shape these outcomes. Findings from this study illustrate that traditional masculine ideals are associated …

Activity Variations Of The Shanzuokou-Sihong Fault Within The Jiangsu Segment Of The Tancheng-Lujiang Fault Zone And Their Origins, Zhang Hao, Li Wei, Li Limei, Yan Yunxiang, Jiang Xin, Wang Jinyan, Zhao Qiguang, Gu Qinping, Xu Hangang

Coal Geology & Exploration

The Shanzuokou-Sihong fault, having undergone the entire evolutionary process of the Tancheng-Lujiang fault zone, exhibits segmentation during the latest activity epoch. Determining the location and origin of its activity segmentation will provide a significant reference for exploring the activity variations of its branch faults and their origins. This study investigated the activity of the Shanzuokou-Sihong fault using a three-dimensional approach combining field geological surveys, shallow seismic exploration, and cross-well stratigraphic correlation. The results show that the Shanzuokou-Sihong fault is a Late Pleistocene active fault on the east side of the North Maling Mountain and a Middle Pleistocene fault in Xinyi …

Revealing Fine-Scale Crustal Structure And Tectonic Features In The Xiong’An New Area And Its Periphery Using Deep Seismic Reflection Profiling, Yue Hangyu, Wang Kai, Wang Xiaojiang, Zhang Baowei, Zhang Kai

Coal Geology & Exploration

As an effective method to accurately reveal the deep geological structures and tectonic features of the Earth, deep seismic reflection profiling has been increasingly applied to the exploration of the continental and oceanic crusts, as well as the upper mantle of the lithosphere, making it internationally recognized pioneer technique for deep Earth exploration. This study examined the deep seismic reflection profile spanning across the Xiong’an New Area in Hebei Province, aiming to reveal the crustal structure and tectonic features of the study area. Key findings are as follows: (1) The crust in the study area can be divided into the …

Application Of Integrated Geophysical Surveys In The Identification Of Hidden Fire Sources In Spontaneous Combustion Zones In Coal Seams, Ma Zijun, Yang Haiyan, Li Wenyu, Xu Yunlei, He Yunlan, Liu Zhuoming, Li Peng, Huang Jiu

Coal Geology & Exploration

Spontaneous combustion in coal seams, a factor influencing the development of many mining areas in China, can cause severe coal resource loss and environmental pollution. The positioning and distribution identification of hidden fire sources can provide an important basis for coal mine enterprises to prepare prevention and control measures. They are also a hot research topic and challenge in the field of coal fire disasters. Suitable channels for ventilation and oxygen supply are necessary for spontaneous combustion in coal seams. When the oxidative heat release rate of coals exceeds the heat dissipation rate, coal temperature will rise until the occurrence …

Integration Of Massive Open Online Course (Mooc) In Conventional Teaching And Learning For Fixed Prosthodontics - A Case Study, Nor Faharina Abdul Hamid, Rohana Ahmad, Tong Wah Lim, Nur Hafizah Kamar Affendi, Tengku Fazrina Tengku Mohd Ariff, Melati Mahmud, Siti Mariam Ab Ghani

Journal of Dentistry Indonesia

The potential for Massive Open Online Courses (MOOCs) in clinical dentistry remains vague and inadequately explored. Objectives: The study aims to obtain insight into the development of MOOCs in Fixed Partial Dental Prostheses (FPDPs) and to assess students’ learning preferences, module quality, and interface usability. Methods: The MOOCs was created by seven academicians with prosthodontic backgrounds. After completing the MOOCs and three complementary online discussion sessions, the students (n = 89) were invited to participate in an online survey. SPSS version 23 was used to calculate the frequency, percentage, mean, and standard deviation of categorical data (SD). Results …

Clinically Effective Regenerative Therapy For Primary Endodontic Lesions With Secondary Periodontal Lesions: A Case Report, Martina Amalia, Budi Budi, Iceu Estu Kurmaena, Nevi Yanti, Hesty Nurcahyanti, Aini Hariyani Nasution

Journal of Dentistry Indonesia

The diagnosis and prognosis of teeth with endo-perio lesions present a major challenge for dentists. Proper diagnosis is critical in determining treatment and the long-term prognosis. However, treating complex endodontic and periodontal lesions is one of the most common challenges in current clinical practice. The coexistence of pulpal and periodontal tissue damage may complicate diagnosis and further influence dental prognosis. This article consists of a case report evaluating the efficacy of xenografts and resorbable membrane pericardium in treating bifurcation lesions associated with periodontal lesions of the left mandibular first molar. A 22-year-old female patient was referred by conservative dentistry with …

Chromium-Contaminated Sites: Migration Characteristics And Monitoring Using Dual-Frequency Ip Method, Wei Kaiyao, Liu Zhimin, Liang Chen, Zhang Jie, Ma Qiang

Coal Geology & Exploration

Given that the migration process of chromium-contaminated sites is subjected to various uncertainties, it is difficult to investigate the migration characteristics and explore the monitoring process using experiments. Based on the basic law of groundwater flow and the migration mechanisms of pollutants, this study conducted a simulation analysis of the migration characteristics of static chromium contamination sources and the law of changes in the migration characteristics using the COMSOL software. Then, this study verified the reliability and accuracy of numerical forward simulations through physical simulation experiments on a static soil bin. Specifically, using the model of chromium contamination source migration …

Dual-Frequency Transmission Radio Wave-Based Exploration Method And Its Application, Fu Xianjie, Hu Ze'an, Wu Rongxin, Li Peng

Coal Geology & Exploration

Coal seams can act as the guided wave layers of high-frequency electromagnetic waves, and radio wave perspective technology can be used to detect geological structures within coal seams of a working face. Presently, radio wave perspective methods usually use a single frequency, leading to some problems such as improper frequency selection and limited detection accuracy in the exploration of mining faces. In response, this study developed a dual-frequency transmission radio wave-based exploration method. Based on theoretical analysis, as well as the field strength of dual-frequency perspective and attenuation coefficient, this study derived the calculation formula for the absorption factor γ …

The Application Of The Opposing Coils Transient Electromagnetic Method And Microtremor Survey Method In Shallow Karst Detection, Zhang Xueliang, Xie Tao, Zhou Wei, Gao Hui, Deng Dong, Qu Jingyi

Coal Geology & Exploration

Concealed karsts frequently lead to disasters such as ground collapse, water reservoir seepage, and tunnel water inrush. Identifying the distribution and development of karsts in advance holds great significance for guiding engineering design and construction in karst areas. Geophysical methods rank among the most effective methods for karst detection. Given the problems of karst development, limited space, and serious electromagnetic interference in the tank farms of the Longkou Port, Shandong Province, this study explored shallow karsts in these farms through the joint application of the opposing coils transient electromagnetic (OCTEM) method and the microtremor survey method. Firstly, surface scanning was …

Poor Cognition Is Associated With Increased Abundance Of Alistipes And Decreased Abundance Of Clostridium Genera In The Gut, Jazmyn A. Muhammad, Yannick Joel Wadop Ngouongo, Sophia Ramirez, Tiffany F. Kautz, Claudia L. L. Satizabal, Jayandra Jung Himali, Sudha Seshadri, Bernard Fongang

School of Medicine Publications

Background: Brain and gut health are intricately connected via the gut-microbiota-brain axis. Studies have shown that gut dysbiosis is associated with neurodegenerative diseases, including Alzheimer’s disease. However, how cognitive changes affects the gut microbiome structure is currently understudied. We aimed to assess the association between the gut microbiome and global cognitive scores in the Framingham Heart Study (FHS).

Method: Our sample included 1,014 participants (mean age 52, 55% female) of the third generation FHS cohort with available stool samples, cognitive assessments, and no history of dementia or stroke (Table 1).We quantified the gut microbiome composition using 16S rRNA …

Advancing The Care Of Individuals With Cancer Through Innovation & Technology: Proceedings From The Cardiology Oncology Innovation Summit 2020 And 2021, Peter Mcgranaghan

All Publications

As cancer therapies increase in effectiveness and patients' life expectancies improve, balancing oncologic efficacy while reducing acute and long-term cardiovascular toxicities has become of paramount importance. To address this pressing need, the Cardiology Oncology Innovation Network (COIN) was formed to bring together domain experts with the overarching goal of collaboratively investigating, applying, and educating widely on various forms of innovation to improve the quality of life and cardiovascular healthcare of patients undergoing and surviving cancer therapies. The COIN mission pillars of innovation, collaboration, and education have been implemented with cross-collaboration among academic institutions, private and public establishments, and industry and …

Late-Onset Stiff-Person Syndrome: Challenges In Diagnosis And Management, Marinos Dalakas, Jessica Yi

Department of Neurology Faculty Papers

BACKGROUND: Stiff person syndrome (SPS) is a rare slowly progressive autoimmune neuronal hyperexcitability disease with very-high GAD-65 antibody titers that most commonly presents above the age of 20, with muscle stiffness, painful muscle spasms, slow gait, and falls leading to disability. In other autoimmune disorders, late-onset disease has different symptom-spectrum and outcomes, but there is no information regarding late-onset SPS (LOSPS).

OBJECTIVE: Highlight delayed diagnosis and poor tolerance or incomplete response to therapies of patients with LOSPS and outline how best to increase disease awareness early at onset.

DESIGN A RETROSPECTIVE CHART REVIEWMETHODS: We reviewed GAD-positive SPS patients with symptom …

Zirconia Implants: A Mapping Review, Steven J. Sadowsky

Pacific Faculty Work

The advent of zirconia ceramics with excellent mechanical, biomechanical, and optical properties has made them attractive metal-free substitutes for titanium implants. Both animal and human studies have documented shortcomings with titanium implants. A mapping review of the current literature on three iterations of zirconia implant designs has been challenging due to heterogeneous success data and limited follow-up. Zirconia implants hold promise for a new generation of dental implants, but technical developments are needed for design and material enhancements that will need to be validated by long-term rigorous studies.

The 2023 Orthopedic Research Society's International Consensus Meeting On Musculoskeletal Infection: Summary From The In Vitro Section, Noreen J. Hickok, Bingyun Li, Ebru Oral, Sebastian A.J. Zaat, David A. Armbruster, Gerald J. Atkins, Antonia F. Chen, Débora C. Coraça-Huber, Tianhong Dai, Edward M. Greenfield, Rajendra Kasinath, Matthew Libera, Cláudia N.H. Marques, T. Fintan Moriarty, K. Scott Phillips, Kapil Raghuraman, Dacheng Ren, Lia Rimondini, Kordo Saeed, Thomas P. Schaer, Edward M. Schwarz, Christopher Spiegel, Paul Stoodley, Vi Khanh Truong, Shao-Ting Jerry Tsang, Britt Wildemann, Anja R. Zelmer, Annelies S. Zinkernagel

Department of Orthopaedic Surgery Faculty Papers

Antimicrobial strategies for musculoskeletal infections are typically first developed with in vitro models. The In Vitro Section of the 2023 Orthopedic Research Society Musculoskeletal Infection international consensus meeting (ICM) probed our state of knowledge of in vitro systems with respect to bacteria and biofilm phenotype, standards, in vitro activity, and the ability to predict in vivo efficacy. A subset of ICM delegates performed systematic reviews on 15 questions and made recommendations and assessment of the level of evidence that were then voted on by 72 ICM delegates. Here, we report recommendations and rationale from the reviews and the results of …

Advances In Research On Active Faults And Exploration Of Relevant Frontier Scientific Problems, Xu Xiwei, Li Feng, Cheng Jia, Liu Baojin, Chen Guihua, Li Kang, Ren Junjie, Jia Qichao

Coal Geology & Exploration

This study reviewed the approval and initiation processes and major research contents of China's active fault-related projects, such as the urban active fault survey projects, large-scale mapping programs of active faults, and the earthquake hazard assessment of active faults in key earthquake monitoring and prevention areas. By combining the scientific investigation results of the surface rupture zones induced by strong earthquakes over the past 20 years, this study elaborated on significant advances achieved in the following aspects: the survey and positioning techniques for concealed active faults under strong-noise and weak-signal conditions, the quantitative identification techniques for fault activity, theories and …

Optimization Of Data Acquisition Parameters For Deep Seismic Reflection Surveys In Complex Terrain, Yan Yunxiang, Li Pei, Zhi Min, Liu Jianda, Wang Zichen, Zhang Ying, Pei Gendi, Li Linyuan, Mou Qi, Jia Jin

Coal Geology & Exploration

Fujian, located in the orogen region of the coastal areas of southeast China, exhibits well-developed structures and complex surface conditions, which make deep seismic reflection surveys challenging. In response to the diversity and complexity of seismogeological conditions in Fujian, this study optimized the seismic excitation means based on previous deep seismic surveys. Specifically, the combination of large, medium, and small guns was transitioned into the layout of normal guns (spacing of shot points: 600 m) and large shots (spacing of shot points: 15 km), leading to enhanced folds of large shots. Through simulation analysis, this study calculated the spacing of …

Mechanical Behavior And Failure Response Characteristics Of Hard Sandstones Considering Bedding Dip Angles, Song Zhanping, Liu Hongke, Zheng Fang, Cheng Yun, Sun Yinhao, Song Wanxue

Coal Geology & Exploration

This study focuses on the mechanical behavior and failure responses of hard sandstones considering bedding dip angles. Through uniaxial compression tests of hard sandstones with different bedding dip angles, this study delved into the influence of bedding dip angles on the mechanical behavior of hard sandstones and the relationship between the bedding dip angles and fractal characteristics of hard sandstone fragments. The test results show that bedding dip angles produced negligible effects on the type of the stress-strain curves of hard sandstones. However, low dip angles (0°, 22.5°, and 45°) corresponded to unimodal curves, while high dip angles (67.5° and …

Enhanced Bmp Signaling In Cathepsin K-Positive Tendon Progenitors Induces Heterotopic Ossification, Hiroyuki Yamaguchi, Margaret Li, Megumi Kitami, Sowmya Swaminathan, Yuji Mishina, Yoshihiro Komatsu

Faculty, Staff and Student Publications

Heterotopic ossification (HO) is abnormal bone growth in soft tissues that results from injury, trauma, and rare genetic disorders. Bone morphogenetic proteins (BMPs) are critical osteogenic regulators which are involved in HO. However, it remains unclear how BMP signaling interacts with other extracellular stimuli to form HO. To address this question, using the Cre-loxP recombination system in mice, we conditionally expressed the constitutively activated BMP type I receptor ALK2 with a Q207D mutation (Ca-ALK2) in Cathepsin K-Cre labeled tendon progenitors (hereafter “Ca-Alk2:Ctsk-Cre”). Ca-Alk2:Ctsk-Cre mice were viable but they formed spontaneous HO in the Achilles tendon. Histological and molecular …

Comparison Of Edta And Boric Acid Irrigation In Terms Of Root Canal Dentin Microhardness And Sealer Penetration Depth, Selen İnce Yusufoğlu, Esma Saricam, Neslihan Bulak, Mustafa Güngörmüs, Fatih Tulumbacı, Suat Özcan

Journal of Dentistry Indonesia

Chemo mechanical preparation is one of the important stages for successful endodontic treatment, and Boric acid has been proposed as an alternative irrigation solution for root canal treatment. Objective: The purpose of this study was to evaluate the effect of irrigation with boric acid (BA) and EDTA on the mineral content and microhardness of dentin and penetration of the AH Plus root canal sealer. Methods: 63 single-rooted teeth were instrumented. Microhardness analysis, 45 teeth were cut longitudinally and then transversely to obtain dentin. Pre- and post-treatment microhardness values were measured. The samples were randomly assigned into 3 groups …

Effect Of Triple Antibiotic Paste, Double Antibiotic Paste, And Calcium Hydroxide On Antibiotic Resistance Of Tet Repressor Proteins, Tetracycline Resistance Gene W, And Tetracycline Resistance Gene Q: A Randomized Controlled Clinical Trial, Ertuğrul Karataş, Özgen Kırmızıbekmez, Mustafa Özkan Baltacı, Ahmet Adıgüzel

Journal of Dentistry Indonesia

Objective: To investigate the effect of the use of Calcium Hydroxide (Ca(OH)2), Triple Antibiotic Paste (TAP), and Double Antibiotic Paste (DAP) as intra-canal medicaments on the development of antibiotic resistance by evaluating tetracycline genes. Methods: Forty five patients were randomly assigned into 3 groups according to the intracanal medication using a web program (www.randomizer.org), (Ca(OH)2, TAP and DAP). Root canal bacteriological samples were collected before root canal treatment (S1) and after chemo-mechanical procedures (S2). Following root canal shaping procedures, intra-canal medication of the root canals was performed with selected intra-canal medicament. A second appointment was planned for the …

Evaluation Of Trabecular Bone Around The Impacted Maxillary Canine On Cbct Images By Fractal Analysis, Zeynep Betül Arslan, Berrin Çelik

Journal of Dentistry Indonesia

Objective: The aim of this study was to evaluate the position, angulation and surrounding trabecular bone structure of a unilateral impacted maxillary canine (IMC) tooth using fractal analysis. Methods: Cone beam computed tomography images of 50 patients (38 female, 12 male) with unilateral IMC were selected for this retrospective study. A 25x25 pixel region of interest (ROI) was selected in the trabecular bone between the premolars on the impacted and non-impacted side and fractal analysis was conducted. The angulation of unilateral impacted canines was measured and the position was categorized as vestibular, intra-alveolar and palatal. Results: Of …

The Effect Of Several Electric Cigarette Puffs On Nanohybrid Composite Resin Surface Roughness, Alvi Rizqi Amaliyah, Haris Budi Widodo, Irfan Dwiandhono

Journal of Dentistry Indonesia

Nanohybrid composite resin is a dental restorative material comprising micro and nano-sized fillers. When accompanied by smoking habits, it can alter the surface roughness of composite resin. Objective: This study aimed to determine the effect of several electric cigarette (e-cigarette) puffs on the surface roughness of nanohybrid composite resin. Methods: This study was conducted in the experimental laboratory with a pretest-posttest control group design using 48 nanohybrid composite resin specimens divided into six groups. Subsequently, the experimental groups were exposed to 75, 150, 225, 300, and 450 puffs of e-cigarette, and the control group was given artificial saliva …

Management Of Ankyloglossia In A Non-Syndromic Patient Using A Super Pulsed Laser: A Life-Changing Treatment- A Case Report, Urfi Jawed, Afaf Zia, Ramniwas Kumawat, Afshan Bey, Maahin Mahmood

Journal of Dentistry Indonesia

Objective: Ankyloglossia affects a person’s overall well-being and life, from malnutrition due to poor feeding and mechanical problems to psychological stress and low self-esteem, thus affecting social life. This case reports the use of non-scalpel techniques, such as a super pulsed laser, to manage ankyloglossia in a non-syndromic patient suffering from speech incompetence and restricted tongue mobility and highlights its advantages over other conventional techniques. Case Report: A 17-year-old male patient presented with a complaint of restricted tongue mobility, due to which he could not pronounce certain words clearly. As the patient was apprehensive about the use of …