Digital Commons Network^™

Unh Celebrates Students And Alumni At Annual Social Venture Innovation Challenge, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Strategies Small Business Owners In North Carolina Use To Sustain Their Business, Curtis Delbert Mccullough

Walden Dissertations and Doctoral Studies

No abstract provided.

Achieving Organizational Sustainability Through Gender-Diverse Strategies For Builder Leaders’ Succession Planning, Lisa Hawkins-Saleemi

Walden Dissertations and Doctoral Studies

No abstract provided.

Hubungan Tingkat Berat Jenis Urin Dengan Keluhan Kesehatan Akibat Pajanan Panas Pada Pekerja Konstruksi Depo Lrt, Muhammad Syafiq Nafis, Doni Hikmat Hikmat Ramdhan

National Journal of Occupational Health and Safety

Background: Construction workers in Indonesia are among vulnerable workers of the negative impact of heat hazard from the work environment. Past research has found that more than 80% of construction workers experienced dehydration and 100% construction workers have experienced heat-related symptoms/illnesses. Objective: The purpose of this study is to analyze the correlation between dehydration (based on urine specific gravity) and heat-related symptoms/illnesses in depo Light-Rail Transit (LRT) construction workers. Methods: This study used a cross-sectional method from secondary data of work environment heat level measurement, workers’ questionnaire, and workers’ urine specific gravity in depo LRT construction 2021. Results : There …

Analisis Faktor Risiko Gangguan Otot Rangka Akibat Kerja Pada Pekerja Perkantoran Di Instansi X Tahun 2023, Alvina Winners Putri, Indri Hapsari Hapsari Susilowati

National Journal of Occupational Health and Safety

An uncomfortable posture when doing work for a long duration can cause work-related musculoskeletal disorders. The purpose of this study was to determine the risk factors associated with the occurrence of symptoms of work-related musculoskeletal disorders in office workers at Institution X in 2023. This study used a cross-sectional design and the occupational posture assessment Rapid Office Strain Assessment (ROSA) method then to assess complaints of musculoskeletal disorders as a whole subjectively using the NBM (Nordic Body Map). The results showed that the level of risk of complaints of musculoskeletal disorders due to work at the intermediate level requires further …

Evaluation Of The Cytotoxic Effect Of Titanium Dioxide Nanoparticles In Human Embryonic Lung Cells, Olkan Afşar, Çağatay Oltulu

Turkish Journal of Medical Sciences

Background/aim: Titanium dioxide nanoparticles are widely used in a variety of products, including sunscreens, paints, and ceramics. However, their increasing use has raised concerns about their potential health risks. Titanium dioxide nanoparticles have been shown to have the ability to enter the bloodstream and accumulate in various tissues, reaching the fetus via the placenta. The aim of this study was to investigate the cytotoxic effects of titanium dioxide nanoparticles on a human embryonic lung cell line (HEL 299/An1) and the formation of oxidative DNA damage. Materials and methods: The cytotoxic effects of brookite-based titanium dioxide nanoparticles (<100 nm) were assessed using the 3-(4,5-dimethyldiazol-2-yl)-2,5 diphenyl tetrazolium bromide (MTT) assay for 24 and 48 h. Cell titanium levels were determined using inductively coupled plasma mass spectrometry. Oxidative DNA damage was assessed by measuring the levels of 8-hydroxy-2- deoxyguanosine (8-OHdG) as a biomarker. Results: Titanium dioxide nanoparticles caused dose-dependent cytotoxicity in HEL 299/An1 cells. The IC50 values were 25.93 μM and 0.054 μM after 24 h and 48 h of exposure, respectively. Cell titanium levels were found to be 25,967 ppb after 24 h and 210,353 ppb after 48 h (p < 0.01). 8-OHdG was detected at 32.96 ng/mL after 24 h of exposure and 17.89 ng/mL after 48 h of exposure. Conclusion: In our study, it was shown that titanium nanoparticles caused dose-dependent cytotoxicity and oxidative DNA damage in human embryonic lung cells. The nanoparticles also accumulated in cells and were taken up in higher amounts after 48 h of exposure. These findings suggest that titanium dioxide nanoparticles may pose a health risk, especially for pregnant women who may not be aware of their pregnancy. Therefore, it is important to take preventive measures to reduce exposure to these nanoparticles.

Assessment Of Changes In Macular Structural Retinal Layers In Patients With Pathological Myopia, Mehmet Çitirik, Kami̇l Yavuzer, Fatma Bağci

Turkish Journal of Medical Sciences

Background/aim: This study aimed to examine changes in the thickness of individual macular retinal layers in eyes with pathological myopia (PM) and to compare the thickness of each retinal layer between the PM and control groups to gain insights into retinal perfusion. Materials and methods: The study included 51 eyes in the PM group and 51 eyes in the control group. Optical coherence tomography (OCT) was used to measure the thickness of each retinal layer in the central fovea, parafoveal, and perifoveal regions. Optical coherence tomography angiography (OCT-A) was used to evaluate the retinal capillary density. Results: In the PM …

Development Of An Optical Test Bed For The Fabrication And Characterisation Of An Analog Holographic Wavefront Sensor, Emma Branigan, Andreas Zepp, Suzanne Martin, Matthew Sheehan, Szymon Gladysz, Kevin Murphy

Conference Papers

A new holographic recording setup has been developed for the fabrication of single- and multi-mode photopolymer-based analog holographic wavefront sensors. A second setup has been built and used to characterise the sensor at several wavelengths.

Commercial Adsorbents For Co2 Removal For Biogas Upgradation: An Experimental Study, Aakriti Bagla

McKelvey School of Engineering Graduate Student Theses & Dissertations

No abstract provided.

How Are Oregon's Rural Indigenous Communities Overcoming Water Access Issues?, Tyren John Thompson

Dissertations and Theses

This study investigates how water insecurity affects Indigenous communities in Grand Ronde, Warm Springs, and Umatilla, Oregon, through loss of clean drinking water, access to culturally significant foods, and exposure to pollution. Each community offers innovative solutions drawing on their Indigenous knowledge to overcome water supply challenges. Communities with more resources are better equipped to cope with water insecurity and environmental degradation.

Oncogenic Kras Drives Lipofibrogenesis To Promote Angiogenesis And Colon Cancer Progression, Wen-Hao Hsu, Kyle A Labella, Yiyun Lin, Ping Xu, Rumi Lee, Cheng-En Hsieh, Lei Yang, Ashley Zhou, Jonathan M Blecher, Chang-Jiun Wu, Kangyu Lin, Xiaoying Shang, Shan Jiang, Denise J Spring, Yan Xia, Peiwen Chen, John Paul Shen, Scott Kopetz, Ronald A Depinho

Faculty, Staff and Student Publications

Oncogenic KRAS (KRAS*) contributes to many cancer hallmarks. In colorectal cancer, KRAS* suppresses antitumor immunity to promote tumor invasion and metastasis. Here, we uncovered that KRAS* transforms the phenotype of carcinoma-associated fibroblasts (CAF) into lipid-laden CAFs, promoting angiogenesis and tumor progression. Mechanistically, KRAS* activates the transcription factor CP2 (TFCP2) that upregulates the expression of the proadipogenic factors BMP4 and WNT5B, triggering the transformation of CAFs into lipid-rich CAFs. These lipid-rich CAFs, in turn, produce VEGFA to spur angiogenesis. In KRAS*-driven colorectal cancer mouse models, genetic or pharmacologic neutralization of TFCP2 reduced lipid-rich CAFs, lessened tumor angiogenesis, and improved overall survival. …

New Age Insights: Filipino Millennials In Government, Mark Kevin C. Chua, Sherrie Ann C. Labid, Lovely Rose A. Bolante

Makara Human Behavior Studies in Asia

Millennials comprise a significant portion of the demography of the current Philippine workforce. Cognizant of the unique socio-cultural environment that shaped the Generation Y cohort, this descriptive phenomenological qualitative study aimed to explore millennial employees' work expectations and experiences within a government agency in the Philippines. Four themes emerged from the in-depth analysis of the five employees' interview responses: (1) job security and financial stability, (2) socio-emotional support, (3) fulfillment, and (4) professional development opportunities. The qualitative findings of this study emphasize the importance of supporting millennial employees' career growth and fostering a healthy work environment. It indicates that millennial …

Coastal Wetland Restoration Through The Lens Of Odum's Theory Of Ecosystem Development, Friedrich W. Keppeler, Annette S. Engel, Linda M. Hooper-Bùi, Paola C. López-Duarte, Charles W. Martin, Jill A. Olin, Katelyn J. Lamb, Michael J. Polito, Nancy N. Rabalais, Brian J. Roberts, Erick M. Swenson, Olaf P. Jensen

Michigan Tech Publications

Advancing ecological restoration assessments requires a more detailed consideration of species interactions and ecosystem processes. Most restoration projects rely on a few metrics not always directly linked with ecological theory. Here, we used Odum's theory of ecosystem development to assess and compare the ecosystem structure and services of created marshes (4–6 years old) with preexisting, reference marshes in a brackish water region of the Mississippi River Delta. We built ecosystem models for created and reference marshes that integrated large datasets of stomach contents, stable isotopes, and taxa abundances. Despite strong resemblance in community structure, created marshes were at an earlier …

Guidelines For Sustainable Use Of Mobile Instant Messaging Apps In Higher Education: A South African Case Study, Bronwyn C. Swartz, Sweta Patnaik

Higher Learning Research Communications

Objective: The purpose of the study was to propose guidelines to facilitate the sustainable and successful use of mobile instant messaging apps for learning and teaching based on a review of the literature and perceptions of educators. Fraser’s model of redistribution, recognition, and representation served as the theoretical framework. This study provides a mechanism for the development of a socially just and inclusive online classroom environment.

Method: We conducted two focus groups (n = 4 and n = 3) in November 2021 at a university of technology in South Africa to explore the perceptions of educators on using mobile …

Circulating Senescent Myeloid Cells Infiltrate The Brain And Cause Neurodegeneration In Histiocytic Disorders, C Matthias Wilk, Flurin Cathomas, Orsolya Török, Jessica Le Berichel, Matthew D Park, Camille Bigenwald, George R Heaton, Pauline Hamon, Leanna Troncoso, Brooks P Scull, Diana Dangoor, Aymeric Silvin, Ryan Fleischmann, Meriem Belabed, Howard Lin, Elias Merad Taouli, Steffen Boettcher, Long Li, Antonio Aubry, Markus G Manz, Julia K Kofler, Zhenyu Yue, Sergio A Lira, Florent Ginhoux, John F Crary, Kenneth L Mcclain, Jennifer L Picarsic, Scott J Russo, Carl E Allen, Miriam Merad

Faculty, Staff and Students Publications

Neurodegenerative diseases (ND) are characterized by progressive loss of neuronal function. Mechanisms of ND pathogenesis are incompletely understood, hampering the development of effective therapies. Langerhans cell histiocytosis (LCH) is an inflammatory neoplastic disorder caused by hematopoietic progenitors expressing mitogen-activated protein kinase (MAPK)-activating mutations that differentiate into senescent myeloid cells that drive lesion formation. Some individuals with LCH subsequently develop progressive and incurable neurodegeneration (LCH-ND). Here, we showed that LCH-ND was caused by myeloid cells that were clonal with peripheral LCH cells. Circulating BRAFV600E

A Patterned Human Primitive Heart Organoid Model Generated By Pluripotent Stem Cell Self-Organization, Brett Volmert, Chao Zhou, Et Al.

2020-Current year OA Pubs

Pluripotent stem cell-derived organoids can recapitulate significant features of organ development in vitro. We hypothesized that creating human heart organoids by mimicking aspects of in utero gestation (e.g., addition of metabolic and hormonal factors) would lead to higher physiological and anatomical relevance. We find that heart organoids produced using this self-organization-driven developmental induction strategy are remarkably similar transcriptionally and morphologically to age-matched human embryonic hearts. We also show that they recapitulate several aspects of cardiac development, including large atrial and ventricular chambers, proepicardial organ formation, and retinoic acid-mediated anterior-posterior patterning, mimicking the developmental processes found in the post-heart tube stage …

Migrant Labour Protection In Asean, In What Way Does Ilo Matter?, Dwi Ardhanariswari Sundrijo, Dhanny Safitri

Global: Jurnal Politik Internasional

Despite the importance of labour migration in Southeast Asia, the mechanism of migrant workers protection in the region is still lacking. Because of that, cases show that often the undocumented and/or the low-skilled workers receive inappropriate treatment in the host countries. In certain cases, they were treated as second-class citizens – this is despite the work that they do. To address these issues, ASEAN has conducted a series of dialog forums and issued various agreements. In doing so, ASEAN have been involving different key stakeholders working on the issue, including international organizations, regional and national civil society organizations, and employers’ …

About Books, Mark Lynch

Bird Observer

No abstract provided.

About Books: That Was Then. This Is Now, Mark Lynch

Bird Observer

No abstract provided.

Birding The Dorothy Frances Rice Sanctuary For Wildlife In Peru, Massachusetts, Robert Tougias

Bird Observer

No abstract provided.

Wired Birder: Sneaking A Peek At Birds, David M. Larson

Bird Observer

No abstract provided.

About Books : Who Are Those Guys? A Conversation With Josep Del Hoyo, The Creator Of The Handbook Of The Birds Of The World Series, Mark Lynch

Bird Observer

No abstract provided.

Cooper’S Hawks: A Population Study With A Brief Discussion Of Sharp-Shinned Hawks, Lawrence B. Fischer

Bird Observer

No abstract provided.

Birding The Blackstone Valley: Uxbridge-Northbridge, Massachusetts, Richard W. Hildreth, Strickland Wheelock

Bird Observer

No abstract provided.

A Hermit Thrush Foraging For Northern Red-Backed Salamanders, Frederick Thurber

Bird Observer

No abstract provided.

He Spanned Two Eras: Charles Foster Batchelder, Last Of The "Shotgun" Ornithologists, William E. Davis Jr.

Bird Observer

No abstract provided.

The Silvio O. Conte National Fish And Wildlife Refuge, Beth Goettel

Bird Observer

No abstract provided.

Wildlife Viewing In The Great Swamp, Chris Raithel

Bird Observer

No abstract provided.

Bird Sightings: July 1997 Summary, Marjorie W. Rines, Simon Perkins, Robert H. Stymeist

Bird Observer

No abstract provided.

Birding Rhode Island's Easy Bay Bike Path, Steve Davis

Bird Observer

No abstract provided.