Digital Commons Network^™

Amgen V. Sanofi And The Return Of Patent Formalism To The Supreme Court, Laura Pedraza-Fariña

Chicago-Kent Journal of Intellectual Property

No abstract provided.

Some Thoughts On Warhol And The Future Of Transformative Works, Zvi S. Rosen

Chicago-Kent Journal of Intellectual Property

No abstract provided.

Modeling The Behavior Of The Sand Dunes And Dry Soils Index (Ndsdi) And Its Role In Detecting The Effects Of Climate Change In Samawa District For The Period (1993-2008-2023), Sarhan Naeem Al-Khafaji, Osama Faleh Abdel Hassan Al-Maktoub

Uruk Journal of Human Sciences

The problem of climate change is one of the important challenges facing countries of the world in general, especially countries that do not have the ability to confront these changes, in addition to the severity of their impact. The field of research was the spatial boundaries of the Samawah District in Al-Muthanna Governorate, as it is bordered on the northern side by the (Al-Hilal, Al-Suwayr, Al-Majd), to the east is Al-Khader District, and to the south and southwest is Al-Salman District. Astronomically, the study area is located between two lines of longitude (45° 4' 10.827" E - 45° 32' 15.364" …

The Impact Of Climate Changes On The Surface Water Environment In Muthanna Governorate And Its Development Implications, Haider Khairy Ghadia Al-Budairi

Uruk Journal of Human Sciences

The impact of climate change is one of the most important causes of water scarcity and drought that Iraq suffers from in general, especially the central and southern regions, which are the most affected, including Al-Muthanna Governorate. The amounts of precipitation led to a decrease in the discharges of the Euphrates River in the study area from (449) m3/sec in 1978 to (111.2) m3/sec in 2022, noting that the rain contributes to feeding the Iraqi rivers by (42-49%) of the total sources. other nutrition, there is no doubt that this huge decrease in the amount of expenditures affected the various …

The Curious Case Of Justice Neil Gorsuch, Justin Burnworth

Pace Law Review

Justice Gorsuch has a propensity for unexpected decisions. His opinions in Bostock v. Clayton County, United States v. Vaello Madero, and McGirt v. Oklahoma confounded the legal community at large. Some argue that his Western upbringing played a role. Others argue that his time clerking for Justice Kennedy primed him for unpredictable decisions. These explanations do not get at the core of Justice Gorsuch’s legal reasoning. This article dives into the depths of these opinions to extract his “Enduring” theories of law. I argue that legal scholarship has incorrectly viewed these three decisions as isolated incidents when they are best …

Navigating Identity, Belonging, And Purpose In A Society In Flux, Chris Rabb

Pace Law Review

Chris Rabb is a family historian, author, and thought leader at the intersection of social identity, civic innovation, and equity. This is a lightly edited transcript of his 2023 Dyson Distinguished Lecture delivered at the Elisabeth Haub School of Law at Pace University on October 25, 2023.

Strategies To Enhance Effectiveness Of School Boards In Governance, Brian Gersich

Doctorate in Education

School boards and superintendents play an important role, providing oversight of the educational services for students in a community. This study sought to understand how public school boards govern a district with their respective superintendents, including if and how this may be evolving. Through this research, I wanted to contribute to the discussion around effective school district governance and management with modernized challenges including an increased focus on social and community cultural issues and the post-pandemic era.

This qualitative study involved interviews with ten school board members currently serving in districts from the Southwest Twin Cities area. Findings indicate the …

Structural Inequality And The New Markets Tax Credit, Michelle D. Layser, Andrew J. Greenlee

Duke Law Journal

The New Markets Tax Credit (“NMTC”) is a federal tax incentive used to promote investment in low-income neighborhoods. Many of these neighborhoods are home to historically marginalized communities. However, very few minority-led institutions participate in the NMTC program. This Article provides the first theoretical and empirical exploration of the underrepresentation of minority-led institutions in the NMTC program. Based on original interviews with representatives of Community Development Entities (“CDEs”), investors, borrowers, and consultants who participate in the NMTC program, this Article describes the “NMTC ecosystem,” a complex, relationship-driven network of NMTC program participants who influence decision-making and create opportunities for success …

Rethinking The Presumption Of Enablement In Nonpatent Prior Art, Gabrielle Carlini

Duke Law Journal

The rising popularity of tools such as preprint servers, open-access data sources, and generative artificial intelligence has resulted in a proliferation of prior art that has never been seen before under the current patent system. In a rapidly changing world, patent law is slow to catch up, and the current system is not equipped to handle the flood of incoming prior art. In the academic research setting in particular, while the use of preprint servers and open-source data has allowed researchers to participate in widespread information exchange, these tools have also generated a new, large class of prior art dedicated …

Education From Condemnations: Learning From State And Federal Reforms For A More Efficient And Just Eminent Domain, Lydia Culp

Duke Law Journal

Under current takings doctrine, governments can identify entire neighborhoods as “blighted,” condemn the private property within, and transfer it to another private owner who will use the land in a more economically advantageous way. This causes injustice by incentivizing governments and developers to target poor and vulnerable neighborhoods. And by letting governments and developers evade market forces, buy land at a bargain, and afford to take on more projects than they can manage effectively, it causes inefficiency. Economic development takings, when not abused, can help revitalize downtrodden neighborhoods, so an outright ban is not the answer. Neither is relying on …

The Role Of Young Architects As Entrepreneurship Generational Units In Shaping The Future Of Architecture, Attaa H. Al Obaidi, Anwar. S. Al-Qaraghuli

Al-Esraa University College Journal for Engineering Sciences

Youth are the pillar of nations and the secret of their renaissance, thebuilders of their civilization and the line of defense, the main participants inbasic planning processes, and the agents of change to build a world that iscompatible with the aspirations of future generations. This applies to the field ofarchitecture in terms of the importance of young architects in shaping it underthe challenges it faces, which impose interaction in a manner commensuratewith the emerging requirements and needs. This research is based on theconsideration that young architects are an integrated phenomenon thatcontributes to shaping architectural production according to the data of …

Bacterial Outer Membrane Vesicles Provide An Alternative Pathway For Trafficking Of Escherichia Coli O157 Type Iii Secreted Effectors To Epithelial Cells, Natalie Sirisaengtaksin, Eloise J O'Donoghue, Sara Jabbari, Andrew J Roe, Anne Marie Krachler

Faculty, Staff and Student Publications

Outer membrane vesicles (OMVs) are proteoliposomes shed by Gram-negative bacteria. Their secretion is enhanced by the transition into the intra-host milieu, and OMVs play critical roles during pathogenesis. Enterohemorrhagic Escherichia coli O157 (EHEC) can cause diarrheal disease in humans, and soluble toxins including Shiga-like toxins that contribute to disease severity and clinical complications like hemolytic uremic syndrome have been shown to be OMV associated. In addition to Shiga-like toxins, EHEC produces a type III secretion system (T3SS), and T3SS effectors are associated with colonization and disease severity in vivo. Here, we show that type III secreted substrates including translocators …

Comparing The Effectiveness Of Mother-Focused Interventions To That Of Mother-Child Focused Interventions In Improving Maternal Postpartum Depression Outcomes: A Systematic Review, Divya Kumar, Waqas Hameed, Bilal Iqbal Avan

Community Health Sciences

Background: Most empirically researched interventions for postpartum depression (PPD) tend to target mothers' depression alone. Harmful effects of PPD on physical and mental health of both mother and child has led researchers to investigate the impact of interventions on PPD and child outcomes together. So far, the evidence is limited regarding how these interventions compare with those focusing only on mothers' depression. This review compares the effectiveness of PPD-improving interventions focusing only on mothers with those focusing on mother and child together.
Methods: Nine electronic databases were searched. Thirty-seven studies evaluating mother-focused (n = 30) and mother-child focused interventions (n …

Storage Protein Activator Controls Grain Protein Accumulation In Bread Wheat In A Nitrogen Dependent Manner, Anne Plessis, Catherine Ravel, Thierry Risacher, Nathalie Duchateau, Mireille Dardevet, Marielle Merlino, François Torney, Pierre Martre

School of Biological and Marine Sciences

The expression of cereal grain storage protein (GSP) genes is controlled by a complex network of transcription factors (TFs). Storage protein activator (SPA) is a major TF acting in this network but its specific function in wheat (Triticum aestivum L.) remains to be determined. Here we generated an RNAi line in which expression of the three SPA homoeologs was reduced. In this line and its null segregant we analyzed GSP accumulation and expression of GSP and regulatory TF genes under two regimes of nitrogen availability. We show that down regulation of SPA decreases grain protein concentration at maturity under low …

Prt543, A Protein Arginine Methyltransferase 5 Inhibitor, In Patients With Advanced Adenoid Cystic Carcinoma: An Open-Label, Phase I Dose-Expansion Study, Renata Ferrarotto, Paul Swiecicki, Dan Zandberg, Robert Baiocchi, Robert Wesolowski, Cristina Rodriguez, Meredith Mckean, Hyunseok Kang, Varun Monga, Rajneesh Nath, Neil Palmisiano, Naveen Babbar, William Sun, Glenn Hanna

Department of Medical Oncology Faculty Papers

OBJECTIVES: Currently, no systemic treatments are approved for patients with recurrent and/or metastatic (R/M) adenoid cystic carcinoma (ACC). PRT543, a protein arginine methyltransferase 5 inhibitor that downregulates NOTCH1 and MYB signalling in tumours, is a potential candidate for R/M ACC treatment. We report the safety, tolerability and preliminary efficacy of PRT543 in a dose-expansion cohort of patients with R/M ACC.

MATERIALS AND METHODS: This phase I multicentre, open-label, sequential-cohort, dose-escalation and dose-expansion study (NCT03886831) enrolled patients with advanced solid tumours and select haematologic malignancies. Dose-escalation study design and results were reported previously. In the dose expansion, patients with R/M ACC …

Determinants Of Young Customers’ Decisions In The Financial Services Market On The Example Of Bank Accounts, Iwona Dorota Czechowska, Weronika Kuśmierska

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

The group of young customers, as a subject of research, is a cognitively interesting social group. Young customers constitute an important purchasing power. The attractiveness of this segment is due to the banks’ perspective, where young customers will become wealthy adults soon, and use the services of the banking sector. The aim of this study is to present and evaluate bank accounts offered to young customers. The authors seek to answer the research question of what the offer of bank accounts dedicated to young customers looks like, whether it is adapted to the needs of this customer group, and whether …

Ten Problems And Solutions For Restoration Of Karst Ecosystem In Southwest China, Xiaoyong Bai, Sirui Zhang, Chen Ran, Luhua Wu, Chaochao Du, Lei Dai, Xingyi Yang, Zilin Li, Yingying Xue, Mingkang Long, Minghui Li, Shu Yang, Qing Luo, Xiaoyun Zhang, Xiaoqian Shen, Fei Chen, Qin Li, Yuanhong Deng, Zeyin Hu, Chaojun Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

The karst areas in southwest China are one of the key but difficult areas targeted in the “Beautiful China” construction initiative, which focuses on soil erosion, proportion of farmland, water pollution, karst drought, ecological restoration, carbon sink, ecological effects of urbanization, rocky desertification management indicators, and biodiversity and sustainability assessment. The study synthesizes the knowledge accumulated during ecological restoration practice in karst areas into 10 problems and solutions that are strong, universal and empirically supported. These problems and solutions help to explain the challenges of achieving sustainability in karst ecology restoration and thus point to solutions. They constitute a core …

Research On Geographical Landscape Design Of Ecological Civilization Construction In China, Wenzhong Zhang, Jianhui Yu

Bulletin of Chinese Academy of Sciences (Chinese Version)

As the fundamental goal of ecological civilization construction in the new era of China, the building of a Beautiful China is an important measure to promote the study of Chinese man-land relationships to a higher level and a new stage of development. This study takes the construction of ecological civilization of Beautiful China as the orientation, and carries on the frame design to the geographical landscape. The geographical landscape takes the elements of geoscience as the research object and makes a series of reasonable outlook about man-land system according to the interaction mechanism of human-land relationship and the influence of …

The Concise Guide To Pharmacology 2023/24: Enzymes, Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, James A. Davies, Stephanie Annett, Detlan Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angela A. Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes-Peter Stasch, Csaba Szabo, Mario Van Der Stelt, Albert Van Der Vliet, Val Watts, Szu Shen Wong

Pharmacy Faculty Articles and Research

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the …

Disrupting Perceptions Of Color Blindness As The Norm: Children’S Talk About Race, Grace Reid

Arts & Sciences Graduate Student Theses and Dissertations

Talking about race can improve children’s ethnic identities, prepare them for encounters with racism, and reduce their racial biases. Yet adults hold intuitive beliefs (e.g., children do not notice race) that limit their conversations about race with children. Children can also initiate conversations about race, but children have been found to avoid talking about race by 10 years. It has been suggested that children avoid talking about race because of colorblind norms, but children’s reasoning about color blindness as a norm is not well understood. Even less is known about the conditions under which children will talk about race. Across …

Discerning The Roles Of Novel Glycosyltransferases In The Pathogenic Yeast Cryptococcus Neoformans, Liza Loza

Arts & Sciences Graduate Student Theses and Dissertations

Cryptococcus neoformans (Cn) is an opportunistic fungal pathogen responsible for over 112,000 deaths each year. This yeast is ubiquitous in the environment, where it is particularly associated with soil, trees, and bird excreta. When a susceptible host inhales infectious particles, Cn can proliferate in the lungs before disseminating to the brain to cause an often-fatal meningoencephalitis. Cryptococcosis primarily afflicts those living with uncontrolled HIV/AIDS, accounting for ~15% of AIDS-related mortality. The antifungals available to treat this devastating disease are few in number, toxic to patients, and largely inaccessible in resource-limited settings. The major virulence factor of Cn is its complex …

The Concise Guide To Pharmacology 2023/24: Catalytic Receptors, Stephen P.H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Annie Beuve, Peter Brouckaert, Clare Bryant, John C. Burnett, Richard W. Farndale, Andreas Friebe, John Garthwaite, Adrian J. Hobbs, Gavin E. Jarvis, Doris Koesling, Michaela Kuhn, David Macewan, Tom P. Monie, Lincoln R. Potter, Michael Russwurm, Harald H.H.W. Schmidt, Johannes-Peter Stasch, Scott A. Waldman

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and nearly 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It …

An Overview Of Neutrosophic Theory In Medicine And Healthcare, Ahmed K. Essa, Ramiz Sabbagh, A. A. Salama, Huda E. Khalid, Abdul-Aziz A. Aziz, Ahmed A. Mohammed

Neutrosophic Sets and Systems

No abstract provided.

Novel Neutrosophic Objects Within Neutrosophic Topology (��(��), ��), Huda E. Khalid, Ramiz Sabbagh, Ahmed A. Salma, Thanoon Y. Thanoon, H. A. Elagamy

Neutrosophic Sets and Systems

No abstract provided.

An Enhanced Generalized Neutrosophic Number And Its Role In Multi-Criteria Decision-Making Challenges, Sumathi I. R, Augus Kurian, Parvathy K

Neutrosophic Sets and Systems

No abstract provided.

Cp-673451, A Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor, Induces Apoptosis In Opisthorchis Viverrini-Associated Cholangiocarcinoma Via Nrf2 Suppression And Enhanced Ros, Jinchutha Duangdara, Boonyakorn Boonsri, Apinya Sayinta, Kittiya Supradit, Pakpoom Thintharua, Supeecha Kumkate, Chinnawut Suriyonplengsaeng, Noppadol Larbcharoensub, Somkit Mingphruedhi, Narongsak Rungsakulkij, Paramin Muangkaew, Pongsatorn Tangtawee, Watoo Vassanasiri, Wikran Suragul, Tavan Janvilisri, Rutaiwan Tohtong, David O Bates, Kanokpan Wongprasert

Faculty, Staff and Students Publications

Platelet-derived growth factors (PDGFs) and PDGF receptors (PDGFRs) play essential roles in promoting cholangiocarcinoma (CCA) cell survival by mediating paracrine crosstalk between tumor and cancer-associated fibroblasts (CAFs), indicating the potential of PDGFR as a target for CCA treatment. Clinical trials evaluating PDGFR inhibitors for CCA treatment have shown limited efficacy. Furthermore, little is known about the role of PDGF/PDGFR expression and the mechanism underlying PDGFR inhibitors in CCA related to Opisthorchis viverrini (OV). Therefore, we examined the effect of PDGFR inhibitors in OV-related CCA cells and investigated the molecular mechanism involved. We found that the PDGF and PDGFR mRNAs were …

The Faculty-To-Faculty Mentorship Experience: A Survey On Challenges And Recommendations For Improvements, Sarvenaz Sarabipour, Natalie M Niemi, Steven J Burgess, Christopher T Smith, Alexandre W Bisson Filho, Ahmed Ibrahim, Kelly Clark

2020-Current year OA Pubs

Faculty at research institutions play a central role in advancing knowledge and careers, as well as promoting the well-being of students and colleagues in research environments. Mentorship from experienced peers has been touted as critical for enabling these myriad roles to allow faculty development, career progression, and satisfaction. However, there is little information available on who supports faculty and best ways to structure a faculty mentorship programme for early- and mid-career academics. In the interest of advocating for increased and enhanced faculty mentoring and mentoring programmes, we surveyed faculty around the world to gather data on whether and how they …

Prey Composition Of Peregrine Falcons (Falco Peregrinus Cassini) Preying Upon A Mixed-Species Seabird Colony In Argentine Patagonia., Germán O. García, María Susana Bó, Pablo Yorio

Ornitología Neotropical

No abstract provided.

Do Rufous-Tailed Jacamars (Galbula Ruficauda) Play With Aposematic Butterflies?, Carlos Eduardo G. Pinheiro, Vitor César De Campos

Ornitología Neotropical

No abstract provided.

Lek Characteristics And The Static Male Song Of The Green Violet-Ear (Colibri Thalassinus) During A 3- Year Study In A Temperate Forest Of Central Mexico, Vanessa Martínez-García, Carlos Lara, Juan Francisco Ornelas

Ornitología Neotropical

No abstract provided.