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2023

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Investigation Of The Deubiquitinating Enzyme Usp7 In The Brain, Hao Chen Dec 2023

Investigation Of The Deubiquitinating Enzyme Usp7 In The Brain, Hao Chen

Arts & Sciences Graduate Student Theses and Dissertations

The development of the nervous system relies on precise control of protein ubiquitination and degradation. Consequently, imbalance in the ubiquitin signaling network is believed to have significant implications for neurological disorders. Recent research has not only detailed the various functions of different ubiquitin ligases in neural development, but has also disclosed the role of deubiquitinating enzyme as an additional regulatory dimension in the ubiquitin signaling network. Specifically, deletion or mutation of the deubiquitinating enzyme USP7 causes the Hao-Fountain syndrome, characterized by developmental delay, intellectual disability, autism, and aggressive behavior. Although USP7 has been studied in proliferating cells in the context …

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Culturally Responsive-Sustaining Computational Thinking: Enactment In Elementary Classrooms, Victoria Macann, Aman Yadav Dec 2023

Culturally Responsive-Sustaining Computational Thinking: Enactment In Elementary Classrooms, Victoria Macann, Aman Yadav

Journal of Computer Science Integration

Technology has increasingly permeated many aspects of everyday life and this evolution raises the need for individuals to understand how the digital world works and what opportunities and risks it brings (Nouri, Zhang, Mannila & Norén, 2019). For this to be an experience for everyone, we need to rethink how we integrate computational thinking (CT) and provide teachers with tools to center their students’ identities, experiences, and cultures in the classroom. In this paper, we present two case studies of primary (elementary) teachers from a full primary (student ages 5–13) semi-rural school in the North Island of New Zealand that …

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The Function Of Ask1 In Sepsis And Stress-Induced Disorders, John Kostyak, Steven Mckenzie, Ulhas Naik Dec 2023

The Function Of Ask1 In Sepsis And Stress-Induced Disorders, John Kostyak, Steven Mckenzie, Ulhas Naik

Cardeza Foundation for Hematologic Research

Apoptosis signal-regulating kinase 1 (ASK1) is a serine-threonine kinase that is ubiquitously expressed in nucleated cells and is responsible for the activation of multiple mitogen-activated protein kinases (MAPK) to regulate cell stress. Activation of ASK1 via cellular stress leads to activation of downstream signaling components, activation of transcription factors, and proinflammatory cytokine production. ASK1 is also expressed in anucleate platelets and is a key player in platelet activation as it is important for signaling. Interestingly, the mechanism of ASK1 activation is cell type-dependent. In this review we will explore how ASK1 regulates a variety of cellular processes from innate immune …

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A Method And A System Of Providing Data Visualization In A Server, Faiz Ahmed, Sudharshan Krishnakumar Gaddam, Thousif Ahmed, Aparajit Lal Kumar Thirukonda Jeyakumar Dec 2023

A Method And A System Of Providing Data Visualization In A Server, Faiz Ahmed, Sudharshan Krishnakumar Gaddam, Thousif Ahmed, Aparajit Lal Kumar Thirukonda Jeyakumar

Defensive Publications Series

The present disclosure provides a method and a system for providing data visualization in a server. In the present disclosure, the server initiates an application of a plurality of applications based on a command provided by a user. Upon execution of the command, the server initiates three actions, namely, creates a web server section, a clean-up section, and a job section. The server may perform jobs based on the command of the user in the job section. The server monitors metrics of the jobs and stores collected metrics. Parallelly, the server may operate a user interface for receiving user request …

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Leadership: Six Studies In World Strategy, Jay Nathan Dec 2023

Leadership: Six Studies In World Strategy, Jay Nathan

Journal of Global Awareness

No abstract provided.

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The Coming Transformative Impact Of Large Language Models And Artificial Intelligence On Global Business And Education, Eva K. Jermakowicz Dec 2023

The Coming Transformative Impact Of Large Language Models And Artificial Intelligence On Global Business And Education, Eva K. Jermakowicz

Journal of Global Awareness

Rapid advances in the capabilities of Large Language Models (LLM) as a basis for Artificial Intelligence (AI) applications, and their sudden wide accessibility, have garnered significant attention recently. These technologies (e.g., ChatGPT, BARD), which have the ability to predict and generate human language, have led to excitement and concerns regarding their use in various industries. This paper explores the history of LLM, examines their applications in business and education, and delves into the critical ethical concerns and challenges of these emerging technologies to ensure that their uses are not only effective, but also responsible and equitable.

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John Dickinson's "Falling Away In Politics," 1774-1776, Matthew Harris Dec 2023

John Dickinson's "Falling Away In Politics," 1774-1776, Matthew Harris

The Thetean: A Student Journal for Scholarly Historical Writing

Of all the Founding Fathers, recorded Benjamin Rush, "few men wrote, spoke and acted more for their country from the years [of] 1764 to the establishment of the federal government than [John] Dickinson." He was one of the only Founding Fathers to play a leading role in most of the significant events surrounding the birth of the American republic-from the Stamp Act Congress in 1765 to the Constitutional Convention of 1787. Yet his standing today compared to that of his fellow revolutionaries is shamefully obscure in view of his contributions.

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Another Look At Japanese Relocation During World War Ii, Anna Maria Allen Dec 2023

Another Look At Japanese Relocation During World War Ii, Anna Maria Allen

The Thetean: A Student Journal for Scholarly Historical Writing

The U.S. government's rationale for relocating people of Japanese ancestry during World War II is seldom explained. Most attention since President Franklin D. Roosevelt issued the order permitting the relocation of individuals of Japanese ancestry from the West Coast to areas in the interior of the United States has naturally been placed on the plight of the people involved. Present popular historical perspective usually interprets this relocation as a constitutional violation worthy of redress from the United States government although historical evidence suggests that at the time the order was issued the action was considered a critical part of U.S. …

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Edvard Benes And His Policy To Expel Czechoslovakian Germans, Travis Mueller Dec 2023

Edvard Benes And His Policy To Expel Czechoslovakian Germans, Travis Mueller

The Thetean: A Student Journal for Scholarly Historical Writing

At the end of World War II, Poland, Romania, Hungary, and the Czechoslovak Republic expelled fifteen million Germans from their homelands in Eastern and Central Europe. During the eviction to the occupied zones of Germany, two million Germans perished.1 Often brutally mistreated, these Germans suffered the wrath of a great European backlash against the Nazis. Nowhere was the expulsion more brutal than in the Czechoslovak Republic. The two nations' shared border and intertwined history made the expulsion of over three million Germans mainly from the Sudetenland-particularly severe.

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Postmodern Philosophy And Its Influence On Modern Museum Theory And Development, Mauri Liljenquist Dec 2023

Postmodern Philosophy And Its Influence On Modern Museum Theory And Development, Mauri Liljenquist

The Thetean: A Student Journal for Scholarly Historical Writing

History legitimizes its role in society through the benefits it provides for the public. The idea of history in the ivory tower, while it appeals to some historians and scholars, can never be sufficient to justify the field. Instead it is what emerges from the ivory tower and how that product influences and affects the outside world that determines the value of historical endeavors. The dissemination of history to the public is one of the most significant aspects of the profession. Accuracy and integrity in research and writing are the primary responsibilities of the historian. Following these, the next most …

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Perpetuated Inferiority, Kristine Ashton Dec 2023

Perpetuated Inferiority, Kristine Ashton

The Thetean: A Student Journal for Scholarly Historical Writing

Nineteenth-century schools taught more than reading, writing, and arithmetic. They were expected to convey patriotism and civic responsibility and to mold moral character. While publishers designed textbooks to teach children to spell and to read, they also inculcated the books with social values through word choice and lesson plans. The printers, journalists, teachers, and ministers who wrote the schoolbooks selectively filled their pages with political, economic, social, and moral concepts that shaped children's views of their nation's past and their position within the present society.

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Review Of Beyond The Icon: Asian American Graphic Narratives By Eleanor Ty, Maite Urcaregui Dec 2023

Review Of Beyond The Icon: Asian American Graphic Narratives By Eleanor Ty, Maite Urcaregui

Asian American Literature: Discourses & Pedagogies

No abstract provided.

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Re-Visions: Examining Narratives Of Asian American Mental Health, Kenji Aoki Dec 2023

Re-Visions: Examining Narratives Of Asian American Mental Health, Kenji Aoki

Asian American Literature: Discourses & Pedagogies

This paper examines the intersection between Asian American mental health and resilience tropes. While research has acknowledged that Asian Americans have disparate mental health gaps regarding mental health stigma and how Asian American young adults are the only racial group in which suicide is their leading cause of death, there has been limited study that attempts to directly convey Asian American voices beyond broad statistical or cultural generalizations. To supplement ongoing research and Asian American livelihoods, this essay conjectures and attempts to illuminate the histories, mental illness, and health narratives of Asian Americans, the good, the bad, the ugly, the …

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Memory, Politics, And Literary Imagination In Viet Thanh Nguyen’S The Refugees, Jian Zhu Dec 2023

Memory, Politics, And Literary Imagination In Viet Thanh Nguyen’S The Refugees, Jian Zhu

Asian American Literature: Discourses & Pedagogies

Despite the official conclusion of the Vietnam War, the struggle for remembrance and recollection endures. Within the pages of The Refugees, Viet Thanh Nguyen offers a transnational lens through which to examine the formation and contestation of collective memories between the United States and Vietnam. Despite its military defeat, the United States appropriated anti-communist ideology during the Cold War era to assimilate the refugee community, leveraging a discourse of “freedom and democracy” as a means to reshape historical narratives. In stark contrast, Vietnam commemorated its revolutionary struggle against imperialism through the establishment of museums, statues, and public cemeteries within …

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The Modular Fiction Of Ken Liu, Elizabeth Lawrence Dec 2023

The Modular Fiction Of Ken Liu, Elizabeth Lawrence

Asian American Literature: Discourses & Pedagogies

Ken Liu is an influential translator of Chinese-language science fiction and an award winning author of original speculative fiction as well. His readers routinely observe that Liu draws on his Chinese heritage for world building and plot development. Less remarked upon are parallels between Liu’s creative process and modular production within Chinese literary and material culture. In this article, I explore these parallels through Liu’s wide-ranging fiction. The intent is not to pigeonhole Liu as a distinctly Chinese or Chinese American author – he has rejected such labels himself – but to universalize models of Chinese creative expression.

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Course Design As Critical Creativity: Intersectional, Regional, And Demographic Approaches To Teaching Asian American Literatures, Thomas X. Sarmiento Dec 2023

Course Design As Critical Creativity: Intersectional, Regional, And Demographic Approaches To Teaching Asian American Literatures, Thomas X. Sarmiento

Asian American Literature: Discourses & Pedagogies

This essay offers a theoretical and reflective exploration of critically informed acts of creativity expressed in my course design for and teaching of Asian American literatures at a predominantly white, public land-grant, Midwestern university. I argue that teaching is both a creative and critical activity as it generates new ways of knowing and being through an assessment and curation of extant literary texts and scholarly discourses. Given my geographic, scholarly, and personal orientations, my course features intersectional, regional, and ethnically diverse perspectives that aim to queer what “Asian America/n” signifies. I hope my situated pedagogical insights inspire other scholar-teachers to …

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"Loving You No Matter What You Do": Ai's Dramatic Monologues, 1970s Asian American Feminisms, And Reproductive Justice, Catherine Irwin Dec 2023

"Loving You No Matter What You Do": Ai's Dramatic Monologues, 1970s Asian American Feminisms, And Reproductive Justice, Catherine Irwin

Asian American Literature: Discourses & Pedagogies

This essay makes visible the 1970s involvement of Asian American and Women of Color feminists in reproductive justice. Grounded in the Asian American feminist praxis of remembering, this essay analyzes how three dramatic monologues by the Asian American mixed-race poet Ai engage with the discourses of reproduce justice set forth by Asian American and Women of Color activists leading up to the 1973 Roe v. Wade decision. Using an Asian American feminist lens, this paper argues that the speakers in Ai’s monologues utilize these discourses circulating about abortion and women’s health care to construct images of the treatment of dispossessed …

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Archiving “Sensitive” Social Media Data: ‘In Her Shoes’, A Case Study, Lorraine Grimes Dr, Kathryn Cassidy Dr, Murilo Dias, Clare Lanigan, Aileen O'Carroll Dr, Preetam Singhvi Dec 2023

Archiving “Sensitive” Social Media Data: ‘In Her Shoes’, A Case Study, Lorraine Grimes Dr, Kathryn Cassidy Dr, Murilo Dias, Clare Lanigan, Aileen O'Carroll Dr, Preetam Singhvi

Journal of Contemporary Archival Studies

Social media play an increasingly significant role in activist and social movements around the globe. Archiving social media is a relatively new phenomenon and an area which needs greater clarity, understanding and uniformity. When it comes to archiving and cataloguing sensitive social media collections, such as personal abortion stories, the process is even more ambiguous. The campaign to repeal the Eighth Amendment (a constitutional ban on abortion) in Ireland saw many such stories shared through online media, particularly in the lead-up to the 2018 referendum. Using the ‘In Her Shoes: Women of the Eighth’ Facebook dataset as a case study, …

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“Big Data” Revitalizing Librarianship: Impact On Librarians, Alice A. Bamigbola Dr. Dec 2023

“Big Data” Revitalizing Librarianship: Impact On Librarians, Alice A. Bamigbola Dr.

Library Philosophy and Practice (e-journal)

Advanced technologies undeniably developed in the 4th Industrial Revolution era, and led to incessantly growing volumes of information daily. “Big Data” is simply information surplus due to the volume, velocity, variety, variability and veracity of the data that need to be processed to get value and better visualisation. Big Data helps libraries understand the ever-changing users’ needs, consequently reshaping their services and procedures. However, it offers several information challenges concerning its capturing, storage, searching, structuring, and visualization. This paper, explores the concept of Big Data in a library environment, how to introduce Big Data, its benefits in the library, roles …

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Vol.51 N.22 December 21th 2023, Voice Media Ventures Dec 2023

Vol.51 N.22 December 21th 2023, Voice Media Ventures

Black Voice News

No abstract provided.

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Vol.51 N.22 December 21, 2023, Voice Media Ventures Dec 2023

Vol.51 N.22 December 21, 2023, Voice Media Ventures

Black Voice News

No abstract provided.

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The Contemporary Tax Journal Volume 12, No. 2 – Winter 2023 Dec 2023

The Contemporary Tax Journal Volume 12, No. 2 – Winter 2023

The Contemporary Tax Journal

No abstract provided.

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The Constitution's Blind Spots: A Discourse Analysis Of Marginalization Within The United States Constitution, Ellie Martel Dec 2023

The Constitution's Blind Spots: A Discourse Analysis Of Marginalization Within The United States Constitution, Ellie Martel

Honors Program Theses and Projects

The United States Constitution begins with the words "We the People,” yet several groups of people were overlooked as it was being crafted. The alienated populace felt that the governing constitution should reflect people of all sexes, genders, races, and nationalities, given the diversity of this nation. Although it took time and effort, the abolitionist and women's rights movements contributed to the formulation of the amendments that would extend constitutional rights to underrepresented groups. The purpose of this thesis is to look deeper at the phrases used in texts to uncover feelings and common themes that presented themselves in speeches …

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Sheila Eyajan V. Nesco Resources Llc Dec 2023

Sheila Eyajan V. Nesco Resources Llc

2023 Decisions

USDC for the Western District of Pennsylvania

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Fulfilling The Radical Power Of Education, Nicole Haberland, Corinne White Dec 2023

Fulfilling The Radical Power Of Education, Nicole Haberland, Corinne White

Gender, Education, Justice, and Equity (GEJE)

No abstract provided.

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Mcpeek V. Dny2 153 Norfolk St. Llc Dec 2023

Mcpeek V. Dny2 153 Norfolk St. Llc

All Decisions

No abstract provided.

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A Mega-Study Of Stereotypes And Attitudes Toward Nationality Groups In The United States, Ayse Selin Toprakkiran Dec 2023

A Mega-Study Of Stereotypes And Attitudes Toward Nationality Groups In The United States, Ayse Selin Toprakkiran

Arts & Sciences Graduate Student Theses and Dissertations

The culture and demographics of the United States have been greatly influenced by numerous immigrant nationality groups, which continue to play a vital role in society. To understand how nationality groups are perceived in the United States, we asked residents to report stereotypes and attitudes toward 28 nationality groups and 6 racial/ethnic groups (N = 7,050). Our findings showed various patterns across 15 stereotypes, grouped under warmth, status, Americanness, and political orientation dimensions. Warmth-related stereotypes and attitudes varied widely across groups and did not follow a discernible pattern. Status-related stereotypes of Asian Americans and East Asian nationality groups were consistently …

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Characterizing The Relationship Between Accented Speech Intelligibility And Listening Effort, Mel Mallard Dec 2023

Characterizing The Relationship Between Accented Speech Intelligibility And Listening Effort, Mel Mallard

Arts & Sciences Graduate Student Theses and Dissertations

Unfamiliar accents can make speech communication difficult, both by reducing speech intelligibility and by increasing the effort listeners must put forth to understand speech. However, these two constructs, while related, are independent: for example, two 100% intelligible utterances may require different amounts of effort to accurately process. To better characterize the relationship between intelligibility and effort, this study presents speakers of four intelligibility levels (one natively-accented English speaker, and three Mandarin-accented English speakers) within a dual-task paradigm (featuring a vibrotactile secondary task) to measure listening effort. We found a negative nonlinear relationship between intelligibility and effort, with the steepest slope …

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Nonprofit Law As The Tool To Kill What Remains Of Campaign Finance Law: Reluctant Lessons From Ellen Aprill, Richard L. Hasen Dec 2023

Nonprofit Law As The Tool To Kill What Remains Of Campaign Finance Law: Reluctant Lessons From Ellen Aprill, Richard L. Hasen

Loyola of Los Angeles Law Review

No abstract provided.

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Long Oligodeoxynucleotides: Chemical Synthesis, Isolation Via Catching-By-Polymerization, Verification Via Sequencing, And Gene Expression Demonstration, Yipeng Yin, Reed Arneson, Alexander Apostle, Adikari M.D.N. Eriyagama, Komal Chillar, Emily Burke, Martina Jahfetson, Yinan Yuan, Shiyue Fang Dec 2023

Long Oligodeoxynucleotides: Chemical Synthesis, Isolation Via Catching-By-Polymerization, Verification Via Sequencing, And Gene Expression Demonstration, Yipeng Yin, Reed Arneson, Alexander Apostle, Adikari M.D.N. Eriyagama, Komal Chillar, Emily Burke, Martina Jahfetson, Yinan Yuan, Shiyue Fang

Michigan Tech Publications

Long oligodeoxynucleotides (ODNs) are segments of DNAs having over one hundred nucleotides (nt). They are typically assembled using enzymatic methods such as PCR and ligation from shorter 20 to 60 nt ODNs produced by automated de novo chemical synthesis. While these methods have made many projects in areas such as synthetic biology and protein engineering possible, they have various drawbacks. For example, they cannot produce genes and genomes with long repeats and have difficulty to produce sequences containing stable secondary structures. Here, we report a direct de novo chemical synthesis of 400 nt ODNs, and their isolation from the complex …

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