Digital Commons Network^™

International Epidemiology Of Carbapenemase-Producing Escherichia Coli, Angelique E Boutzoukas, Lauren Komarow, Liang Chen, Blake Hanson, Souha S Kanj, Zhengyin Liu, Soraya Salcedo Mendoza, Karen Ordoñez, Minggui Wang, David L Paterson, Scott Evans, Lizhao Ge, Abhigya Giri, Carol Hill, Keri Baum, Robert A Bonomo, Barry Kreiswirth, Robin Patel, Cesar A Arias, Henry F Chambers, Vance G Fowler, David Van Duin

Faculty, Staff and Student Publications

BACKGROUND: Carbapenemase-producing (CP) Escherichia coli (CP-Ec) are a global public health threat. We aimed to describe the clinical and molecular epidemiology and outcomes of patients from several countries with CP-Ec isolates obtained from a prospective cohort.

METHODS: Patients with CP-Ec were enrolled from 26 hospitals in 6 countries. Clinical data were collected, and isolates underwent whole-genome sequencing. Clinical and molecular features and outcomes associated with isolates with or without metallo-β-lactamases (MBLs) were compared. The primary outcome was desirability of outcome ranking (DOOR) at 30 days after the index culture.

RESULTS: Of the 114 CP-Ec isolates in Consortium on resistance against …

Experiences And Perceptions Of Rural Postpartum Women With Substance Use Disorders Inclusive Of Opioids Regarding Their Care, Debra L. Kramlich

Dissertations

Perinatal opioid use and neonatal withdrawal continue to rise rapidly in the face of the growing epidemic of opioid addiction in the United States, with rural areas more severely impacted. Despite several decades of research and development of practice guidelines, maternal and neonatal outcomes have not improved substantially. This focused ethnography aimed to address that gap by exploring rural women's experiences and perceptions of care to inform development of efficacious, holistic models of care to improve outcomes for these women and their children. Participant observations, oral accounts and formal interviews, and artifact review (i.e., health records, any print and electronic …

Prenatal Exposure To Maternal Mood Entropy Is Associated With A Weakened And Inflexible Salience Network In Adolescence, Robert J. Jirsaraie, Anton M. Palma, Steven L. Small, Curt A. Sandman, Elysia Poggi Davis, Tallie Z. Baram, Hal S. Stern, Laura M. Glynn, Michael A. Yassa

Psychology Faculty Articles and Research

Background

Methods

Triple-Negative Breast Tumors Are Dependent On Mutant P53 For Growth And Survival, Denada Dibra, Sydney M Moyer, Adel K El-Naggar, Yuan Qi, Xiaoping Su, Guillermina Lozano

Faculty, Staff and Student Publications

The TP53 tumor suppressor gene is mutated early in the majority of patients with triple-negative breast cancer (TNBC). The most frequent TP53 alterations are missense mutations that contribute to tumor aggressiveness. We developed an autochthonous somatic K14-Cre driven TNBC mouse model with p53R172H and p53R245W mutations in which mutant p53 can be toggled on and off genetically while leaving the tumor microenvironment intact and wild-type for p53. These mice develop TNBCs with a median latency of 1 y. Deletion of mutant p53R172H or p53R245W in vivo in these tumors blunts their tumor growth and significantly extends survival of mice. Downstream …

Metapopulation Dynamics Of Sars-Cov-2 Transmission In A Small-Scale Amazonian Society, Thomas Kraft, Edmond Seabright, Sarah Alami, Samuel M. Jenness, Paul L. Hooper, Bret Beheim, Helen Davis, Daniel K. Cummings, Daniel Eid Rodriguez, Maguin Gutierrez Cayuba, Emily J. Miner, Xavier De Lamballerie, Lucia Inchauste, Stéphane Priet, Benjamin Trumble, Jonathan Stieglitz, Hillard Kaplan, Michael Gurven

ESI Publications

The severity of infectious disease outbreaks is governed by patterns of human contact, which vary by geography, social organization, mobility, access to technology and healthcare, economic development, and culture. Whereas globalized societies and urban centers exhibit characteristics that can heighten vulnerability to pandemics, small-scale subsistence societies occupying remote, rural areas may be buffered. Accordingly, voluntary collective isolation has been proposed as one strategy to mitigate the impacts of COVID-19 and other pandemics on small-scale Indigenous populations with minimal access to healthcare infrastructure. To assess the vulnerability of such populations and the viability of interventions such as voluntary collective isolation, we …

Locust Borer, Marion Murray, Ryan Davis

All Current Publications

The locust borer, Magacyllene robiniae, belongs to the longhorned beetle family, referring to the long antennae of most of the species in this group. In Utah, locust borer has damaged black locust trees in most northern Utah counties. The only host is black locust; honeylocust and other trees are not affected by this pest. This fact sheet describes locust borer and its life cycle, symptoms, and control.

Aesthetics Of/And The Universe, Reza Tavakol

Contemporary Aesthetics (Journal Archive)

Modern cosmology has revealed a Universe that is wholly unexpected; a defining feature is that its largest constituent parts are either dark or hidden behind the cosmological horizon, making them in principle unobservable.

These discoveries raise the important question of what constitutes an aesthetic appreciation of the Universe? By considering various modes of appreciation, I argue that a fuller aesthetic appreciation of the Universe would need to augment its visual forms of appreciation with conceptual and imaginative modes of appreciation informed by scientific knowledge.

This argument can have a direct bearing on the long-standing debate concerning the role of cognitive …

Identification Of Usp9x As A Leukemia Susceptibility Gene, Saumya Dushyant Sisoudiya, Pamela Mishra, He Li, Jeremy M Schraw, Michael E Scheurer, Sejal Salvi, Harsha Doddapaneni, Donna Muzny, Danielle Mitchell, Olga Taylor, Aniko Sabo, Philip J Lupo, Sharon E Plon

Faculty, Staff and Students Publications

We recently reported that children with multiple birth defects have a significantly higher risk of childhood cancer. We performed whole-genome sequencing on a cohort of probands from this study with birth defects and cancer and their parents. Structural variant analysis identified a novel 5 kb de novo heterozygous inframe deletion overlapping the catalytic domain of USP9X in a female proband with multiple birth defects, developmental delay, and B-cell acute lymphoblastic leukemia (B-ALL). Her phenotype was consistent with female-restricted X-linked syndromic intellectual developmental disorder-99 (MRXS99F). Genotype-phenotype analysis including previously reported female probands (n = 42) demonstrated that MRXS99F probands with B-ALL …

Early Detection Of Lung Cancer Using Artificial Intelligence-Enhanced Optical Nanosensing Of Chromatin Alterations In Field Carcinogenesis, Ali Daneshkhah, Sravya Prabhala, Parvathi Viswanathan, Hariharan Subramanian, Jianan Lin, Andrew S Chang, Ankit Bharat, Hemant Kumar Roy, Vadim Backman

Faculty, Staff and Students Publications

Supranucleosomal chromatin structure, including chromatin domain conformation, is involved in the regulation of gene expression and its dysregulation has been associated with carcinogenesis. Prior studies have shown that cells in the buccal mucosa carry a molecular signature of lung cancer among the cigarette-smoking population, the phenomenon known as field carcinogenesis or field of injury. Thus, we hypothesized that chromatin structural changes in buccal mucosa can be predictive of lung cancer. However, the small size of the chromatin chain (approximately 20 nm) folded into chromatin packing domains, themselves typically below 300 nm in diameter, preclude the detection of alterations in intradomain …

Clinical Predictors And Outcomes After Left Ventricular Assist Device Implantation And Tracheostomy, Harveen K Lamba, Lucy D Hart, Qianzi Zhang, Jackquelin M Loera, Andrew B Civitello, Ajith P Nair, Mourad H Senussi, Gabriel Loor, Kenneth K Liao, Alexis E Shafii, Subhasis Chatterjee

Faculty, Staff and Students Publications

BACKGROUND: Postoperative respiratory failure is a major complication that affects up to 10% of patients who undergo cardiac surgery and has a high in-hospital mortality rate. Few studies have investigated whether patients who require tracheostomy for postoperative respiratory failure after continuous-flow left ventricular assist device (CF-LVAD) implantation have worse survival outcomes than patients who do not.

OBJECTIVE: To identify risk factors for respiratory failure necessitating tracheostomy in CF-LVAD recipients and to compare survival outcomes between those who did and did not require tracheostomy.

METHODS: Consecutive patients who underwent primary CF-LVAD placement at a single institution between August 1, 2002, and …

The Proteome Of Extracellular Vesicles Of The Lung Fluke Paragonimus Kellicotti Produced In Vitro And In The Lung Cyst, Lucia S Di Maggio, Kerstin Fischer, Devyn Yates, Kurt C Curtis, Bruce A Rosa, John Martin, Petra Erdmann-Gilmore, Robert S W Sprung, Makedonka Mitreva, R Reid Townsend, Gary J Weil, Peter U Fischer

2020-Current year OA Pubs

Paragonimiasis is a zoonotic, food-borne trematode infection that affects 21 million people globally. Trematodes interact with their hosts via extracellular vesicles (EV) that carry protein and RNA cargo. We analyzed EV in excretory-secretory products (ESP) released by Paragonimus kellicotti adult worms cultured in vitro (EV ESP) and EV isolated from lung cyst fluid (EV CFP) recovered from infected gerbils. The majority of EV were approximately 30-50 nm in diameter. We identified 548 P. kellicotti-derived proteins in EV ESP by mass spectrometry and 8 proteins in EV CFP of which 7 were also present in EV ESP. No parasite-derived proteins were …

Interpreting The Mechanism Of Synergism For Drug Combinations Using Attention-Based Hierarchical Graph Pooling, Zehao Dong, Heming Zhang, Yixin Chen, Philip R O Payne, Fuhai Li

2020-Current year OA Pubs

Synergistic drug combinations provide huge potentials to enhance therapeutic efficacy and to reduce adverse reactions. However, effective and synergistic drug combination prediction remains an open question because of the unknown causal disease signaling pathways. Though various deep learning (AI) models have been proposed to quantitatively predict the synergism of drug combinations, the major limitation of existing deep learning methods is that they are inherently not interpretable, which makes the conclusions of AI models untransparent to human experts, henceforth limiting the robustness of the model conclusion and the implementation ability of these models in real-world human-AI healthcare. In this paper, we …

“Killing The Black Body:The Urgency Of Reproductive Justice,” October 11, 2022, Dorothy E. Roberts, Colette Ngana

The International Journal of Ethical Leadership

No abstract provided.

“Moral Courage: When The ‘Line In The Sand’ Demands A Response”, Nikki Coleman

The International Journal of Ethical Leadership

No abstract provided.

Remember The Ladies: A Call To Prioritize Women’S Experiences In Catholic Social Teaching, Erica Lizza

New Horizons

The Church appears to lack a concrete framework for analyzing and responding to violations of women’s dignity. This oversight can be addressed by applying the principles espoused in Catholic Social Teaching to the present-day situation of women worldwide to articulate an affirmative Catholic vision for the protection and promotion of women. This paper examines the tradition of the Catholic Church and her scriptures in order to find positive affirmations of the dignity of women and call to mind places where such affirmations are still lacking. It then seeks to establish a new framework that empowers the Church to more consistently …

Wheat, Rye, And Barley: On Celiac And The Eucharist During The Pandemic, Nathan Jowers

New Horizons

This article ties together reflections on the Eucharist and reflections on the pandemic by appealing to the author’s experiences with celiac disease. Both celiac and the pandemic force Christians to ask the question “What does it mean to approach Christ’s body when it threatens our life?” Acknowledging the complexity of this question is key to understanding and communicating with Christians across the world, especially in high- stakes situations like a pandemic, where misrepresentation runs rampant. The pandemic witnessed the toll of undue simplifications of this question—both in those who denied that liturgy could be a source of danger, and in …

Life-Giving Bodies: Towards An Analogical Relationship Between Breastfeeding And The Eucharist, Laura Tringali

New Horizons

As embodied people who benefit spiritually from the concrete aspects of the sacraments for the understanding of spiritual realities, breastfeeding provides a concrete experience that reflects the bodily self-gift of Christ’s Passion. The analogy of desiring the Eucharist as an infant desiring to latch provides an opportunity to consider the transformative power of the Eucharist to unite one to Christ, nourish one’s spiritual growth, and strengthen the bond of the Body of Christ.

New Horizons Vol.7, Issue 1 2023

New Horizons

No abstract provided.

Evangelical School Of Nursing Bulletin, 1970-1971, Advocate Aurora Health

Historical Documents - Combined

Evangelical School of Nursing, Oak Lawn, IL: Brochure advertising the Evangelical School of Nursing. Includes information on school policies, education requirements, and a course catalog.

Evangelical School Of Nursing Bulletin, 1973-1974, Advocate Aurora Health

Historical Documents - Combined

Evangelical School of Nursing, Oak Lawn, IL: Brochure advertising the Evangelical School of Nursing. Includes information on school policies, education requirements, and a course catalog.

Evangelical School Of Nursing Student Handbook, 1975, Advocate Aurora Health

Historical Documents - Combined

Evangelical School of Nursing, Oak Lawn, IL: Student handbook for the Evangelical School of Nursing.

The Torch, Evangelical School Of Nursing Yearbook, 1960, Advocate Aurora Health

Historical Documents - Combined

Evangelical School of Nursing, Oak Lawn, IL: Evangelical School of Nursing Yearbook from 1960 called "The Torch".

Infrared, Michelle L. Gorodisky

Digressions: Literary & Art Journal

No abstract provided.

Bsc 345 Southern Miss Gulf Scholars Program Module, Southern Miss Gulf Scholars Program

Southern Miss Gulf Scholars

BSC 345 Southern Miss Gulf Scholars Program Curriculum

Throughout this course students will learn about important marine resources that drive the local seafood economy. On a field trip to the Maritime and Seafood Museum, students will learn about this historical seafood industry and industry practices. Student will also tour the USM Thad Cochran Marine Aquaculture Center to learn about modern aquaculture technologies and take an excursion at sea to observe the off-bottom aquaculture site next to Deer Island.

Hanley Sustainability Institute Partners With City For Internships, Dave Larsen

College of Arts and Sciences Newsroom

Three University of Dayton students got first-hand experience this summer working as sustainability professionals for the City of Dayton.

The Effect Of Acute Aerobic Exercise On Measures Of Stress And Inflammation In Healthy Young Adults, Julien Tartar, Anthony Ricci, Jonathan Banks, Hannah Murphy, Cassandra Evans, Jose Antonio, Jaime Tartar

Faculty Articles

Introduction: While the effects of long-term measures of inflammation and stress are well studied, less is known about the effects of an acute exercise challenge on exercise in young healthy individuals. Methods: This was a randomized crossover design (mean age = 19.25, SD = 1.45)that measured biomarkers of stress (cortisoland salivary alpha amylase, sAA)and inflammation (IL-1β, CRP)in an exercise and control condition. In the exercise condition, participants walked or ran on a treadmill at 75-85% of their maximum heart rate for 40minutes. Under the control condition, participants stood for 40 minutes to control for orthostatic effects. Biomarkers were quantified from …

Skin Extracellular Matrix Breakdown Following Paclitaxel Therapy In Patients With Chemotherapy-Induced Peripheral Neuropathy., Nathan P Staff, Sybil C Hrstka, Surendra Dasari, Enrico Capobianco, Sandra Rieger

Faculty Research 2023

The chemotherapeutic agent paclitaxel causes peripheral neuropathy, a dose-limiting side effect, in up to 68% of cancer patients. In this study, we investigated the impact of paclitaxel therapy on the skin of breast cancer patients with chemotherapy-induced peripheral neuropathy (CIPN), building upon previous findings in zebrafish and rodents. Comprehensive assessments, including neurological examinations and quality of life questionnaires, were conducted, followed by intraepidermal nerve fiber (IENF) density evaluations using skin punch biopsies. Additionally, RNA sequencing, immunostaining for Matrix-Metalloproteinase 13 (MMP-13), and transmission electron microscopy provided insights into molecular and ultrastructural changes in this skin. The results showed no significant difference …

August 21, 2023, Ohio University Board Of Trustees Meeting Minutes, Ohio University Board Of Trustees

Board of Trustees Meeting Minutes

Meeting minutes document the activities of Ohio University's Board of Trustees.

Gene Dive: Assessing The Diversity Of Perchlorate Reducing Genes In Mars Analog Environments, Colin Michael Robinson

Theses and Dissertations

Biotic perchlorate reduction, a metabolic process that potentially occurs on Mars, has long been the subject of speculation in astrobiology. To determine whether it could be a viable metabolic strategy on the Red Planet, we sought to determine whether biotic perchlorate reduction could evolve and persist in Mars-analog environments on Earth. In this study, we introduce Gene Dive, a novel computational methodology that leverages profile hidden Markov models, sequence alignment, phylogenetic tree construction, and Faith's phylogenetic diversity to probe the prevalence and diversity of perchlorate reducing genes in metagenomes. To determine whether biotic perchlorate reduction persists in a wide range …

Direct Evidence On The Crossover From Bcc To Fcc Stability: A Lattice-Based Aggregation-Volume-Bias Monte Carlo Approach To Polymorphism, Bin Chen

Faculty Publications

A lattice-based version of the aggregation-volume-bias Monte Carlo method that was introduced recently has allowed for the extension of the calculation of the nucleation free energies from liquid clusters to solid clusters. Here, it was used to calculate the nucleation free energies of both bcc and fcc clusters formed by Lennard-Jones particles. Under the simulation conditions considered in this study, a cross-over of the thermodynamic stability from the bcc to the fcc structure was observed directly from the free energy results. In addition, the free energies obtained for both types of clusters were used to extrapolate bulk phase information, including …