Digital Commons Network^™

Monodisperse Sub-100 Nm Au Nanoshells For Low-Fluence Deep-Tissue Photoacoustic Imaging, Luis D.B. Manuel, Vinoin Devpaul Vincely, Carolyn L. Bayer, Kevin M. Mcpeak

Faculty Publications

Nanoparticles with high absorption cross sections will advance therapeutic and bioimaging nanomedicine technologies. While Au nanoshells have shown great promise in nanomedicine, state-of-the-art synthesis methods result in scattering-dominant particles, mitigating their efficacy in absorption-based techniques that leverage the photothermal effect, such as photoacoustic (PA) imaging. We introduce a highly reproducible synthesis route to monodisperse sub-100 nm Au nanoshells with an absorption-dominant optical response. Au nanoshells with 48 nm SiO2 cores and 7 nm Au shells show a 14-fold increase in their volumetric absorption coefficient compared to commercial Au nanoshells with dimensions commonly used in nanomedicine. PA imaging with Au nanoshell …

Anharmonicity And Deuteration In The Ir Absorption And Emission Spectra Of Phenylacetylene, Vincent J. Esposito, Pierro Ferrari, Wybren Jan Buma, Christiaan Boersma, Cameron J. Mackie, Alessandra Candian, Ryan C. Fortenberry, Alexander G. G. M. Tielens

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Anharmonic cascade emission simulations, herein evinced by full reproduction and deep insights into recent emission spectroscopy experiments of phenylacetylene, are integral to the future successful analysis of JWST observational spectra. Experimental infrared absorption experiments conducted in this study reveal a complex spectrum dominated by quantum effects that are uncovered by anharmonic computational analysis. From this work, it becomes clear that phenylacetylene exhibits strong resonance coupling between fundamental and two-quanta combination modes as well as giving indication for coupling with higher-order, three-quanta combination bands. This study benchmarks the development of advanced computational methods that will be extended to larger systems of …

Researchers Identify Unusually Large Bloom Of Brown Algae In Gulf Of Maine, Robbin Ray

UNH Today Archive

No abstract provided.

Observations Of The Association By Early-Juvenile Western Rock Lobster Panulirus Cygnus George, 1962 With Seagrass Assemblages (Decapoda: Achelata: Palinuridae), Daphne Oh, Tim J. Langlois, Michael A. Brooker, Hugo Salinas, Jason R. How, Simon De Lestang

Fisheries Research Articles

The fishery of the western rock lobster, Panulirus cygnus George, 1962, is Australia’s most valuable wild-caught single-species fishery. Recruitment in some regions of the fishery was observed to be significantly lower than expected after the 2010/2011 West Australian marine heatwave that caused extensive disturbance of dominant coastal habitats. This event generated interest in the study of the factors influencing survival and recruitment of post-larval benthic P. cygnus after settlement. The habitat associations of the highly cryptic post-settlement early-juveniles were previously unknown, with only anecdotal observations of individuals within limestone crevices in nearshore habitats. Our study used early-juveniles derived from …

The Far-Reaching Effects Of Genetic Process In A Keystone Predator Species, Grey Wolves, Sarah Hoy, Philip W. Hedrick, Rolf O. Peterson, Leah Vucetich, Kristin Brzeski, John A. Vucetich

Michigan Tech Publications

Although detrimental genetic processes are known to adversely affect the viability of populations, little is known about how detrimental genetic processes in a keystone species can affect the functioning of ecosystems. Here, we assessed how changes in the genetic characteristics of a keystone predator, grey wolves, affected the ecosystem of Isle Royale National Park over two decades. Changes in the genetic characteristic of the wolf population associated with a genetic rescue event, followed by high levels of inbreeding, led to a rise and then fall in predation rates on moose, the primary prey of wolves and dominant mammalian herbivore in …

Implementing Informatics Tools With Data Management Plans For Disease Area Research, Vivek Navale, Matthew Mcauliffe

Copyright, Fair Use, Scholarly Communication, etc.

Data management plans (DMPs) are essential to a research data life cycle. The DMPs should be developed as part of the research programs to be effective. For disease area research, integrating research community-recommended data standards during collection can enhance the likelihood of data reuse. Informatics tools are required as part of DMPs with the aim of data being findable, accessible, interoperable, and reusable.

The United States National Institutes of Health supports various disease area research programs and has recently finalized the Data Management and Sharing Policy. The policy highlights the importance of sharing data and metadata, including information on various …

Retrospective And Real-Time Measures Of The Quantity Of E-Cigarette Use: An Ecological Momentary Assessment Study, James J Yang, Tzung-Shiang Ou, Hsien-Chang Lin, Joon Kyung Nam, Megan E Piper, Anne Buu

Faculty, Staff and Student Publications

INTRODUCTION: Quantifying e-cigarette use is challenging because of the wide variety of products and the lack of a clear, objective demarcation of a use event. This study aimed to characterize the difference between retrospective and real-time measures of the quantity of e-cigarette use and identify the covariates that may account for discrepancies between the two types of measures.

METHODS: This study analyzed data from 401 college student e-cigarette users in Indiana and Texas who responded to a web survey (retrospective) and 7-day ecological momentary assessments (EMA) (real-time) on their e-cigarette use behavior, dependence symptomatology, e-cigarette product characteristics, and use contexts …

Sediment Sorting Within A Relatively Wave-Exposed And Sandy Subtidal Seagrass (Zostera Marina) Meadow, Gerd Masselink

Faculty of Science and Engineering Datasets

The sediment data set consists of a single spreadsheet with self-explanatory sheets. Sediments were collected from 64 sample locations. The samples were analysed in the laboratory by MSc student Tom Brown and his PhD thesis is included as it contains an extensive description of the analysis methods. Dataset Description: This is the full sediment data set collected in august 2020 from the Great Ganinick seagrass meadow in the isles of Scilly

Integrative Bayesian Tensor Regression For Imaging Genetics Applications, Yajie Liu, Nilanjana Chakraborty, Zhaohui S Qin, Suprateek Kundu

Faculty, Staff and Student Publications

Identifying biomarkers for Alzheimer's disease with a goal of early detection is a fundamental problem in clinical research. Both medical imaging and genetics have contributed informative biomarkers in literature. To further improve the performance, recently, there is an increasing interest in developing analytic approaches that combine data across modalities such as imaging and genetics. However, there are limited methods in literature that are able to systematically combine high-dimensional voxel-level imaging and genetic data for accurate prediction of clinical outcomes of interest. Existing prediction models that integrate imaging and genetic features often use region level imaging summaries, and they typically do …

Ph Gradients In Spatially Non-Uniform Ac Electric Fields Around The Charging Frequency; A Study Of Two Different Geometries And Electrode Passivation, Azade Tahmasebi, Sanaz Habibi, Jeana Collins, Ran An, Esmaeil Dehdashti, Adrienne Minerick

Michigan Tech Publications

Dielectrophoresis (DEP), a precision nonlinear electrokinetic tool utilized within microfluidic devices, can induce bioparticle polarization that manifests as motion in the electric field; this phenomenon has been leveraged for phenotypic cellular and biomolecular detection, making DEP invaluable for diagnostic applications. As device operation times lengthen, reproducibility and precision decrease, which has been postulated to be caused by ion gradients within the supporting electrolyte medium. This research focuses on characterizing pH gradients above, at, and below the electrode charging frequency (0.2–1.4 times charging frequency) in an aqueous electrolyte solution in order to extend the parameter space for which microdevice-imposed artifacts on …

Modifying Attention Away From Food Cues: The Utility Of Attentional Bias Modification Training Among Emotional Eaters, Moet Aita

Theses

The current study (N=153) was designed to explore the relationships between emotional eating and emotion regulation, attentional biases, and food consumption. Emotional eating describes the tendency to eat in response to emotional experiences, especially negative emotions, and is associated with the consumption of high-fat, sugary foods. The present study explored whether food intake could be modified among a sample of emotional and non-emotional eaters by shifting attention away from high-calorie pictorial food stimuli using the attentional bias modification (ABM) training paradigm. Participants were randomly assigned to either the attentional-training group, placebo-training group, or control group. Following the training, participants underwent …

Clot Retraction And Its Correlation With The Function Of Platelet Integrin Α, Daniel Gao, Caroline W Sun, Angela B Woodley, Jing-Fei Dong

Faculty, Staff and Students Publications

Clot retraction results from retractions of platelet filopodia and fibrin fibers and requires the functional platelet αIIbβ3 integrin. This assay is widely used to test the functions of platelets and fibrinogen as well as the efficacy of fibrinolysis. Changes in clot retraction have been found in a variety of hemostatic abnormalities and, more recently, in arterial thrombosis. Despite its broad clinical use and low cost, many aspects of clot retraction are poorly understood. In the present study, we performed two clinical standard clot retraction assays using whole-blood and platelet-rich plasma (PRP) samples to determine how clot retraction correlates with platelet …

The Illinois Biometric Privacy Act: History, Developments, And Adapting Protection For The Future, Margaret M. O'Neil

Student Journal of Information Privacy Law

Biometric technology, used to identify individuals based on their unique, unchangeable attributes such as fingerprints, face prints, and retinas, has grown in use over the last five to ten years as biometrics are incorporated into popular devices and different areas of our lives.1 Today, many people around the world use their face or their thumbprint as a password to unlock their smartphone or complete transactions, and many others use the technology to clock in at work, to see who rang their doorbell at home, or to access secure facilities.

Online Data Transmission Reduction Scheme For Energy Conservation In Wireless Video Sensor Networks, Iman Kadhum Abbood, Ali Kadhum Idrees

Karbala International Journal of Modern Science

Wireless Video Sensor Networks (WVSNs) are networks of low-cost, low-power camera sensor nodes. These nodes communicate locally and process information to meet an application's goal. WVSNs are extensively used in diverse monitoring applications, such as security, military, industrial, medical, and environmental monitoring. However, the transmission of large amounts of data collected by video sensor nodes in WVSNs poses challenges in terms of energy consumption, bandwidth usage, and network congestion. Reducing energy for processing and transmitting data in WVSNs is difficult due to the huge amount of sensed data in real-time. To address this issue, this paper proposes an Online Data …

Biogenesis Synthesis Of Zno Nps: Its Adsorption And Photocatalytic Activity For Removal Of Acid Black 210 Dye, Zahraa A. Najm, Mohammed A. Atiya, Ahmed K. Hassan

Karbala International Journal of Modern Science

This study investigated the treatment of textile wastewater contaminated with Acid Black 210 dye (AB210) using zinc oxide nanoparticles (ZnO NPs) through adsorption and photocatalytic techniques. ZnO NPs were synthesized using a green synthesis process involving eucalyptus leaves as reducing and capping agents. The synthesized ZnO NPs were characterized using UV-Vis spectroscopy, SEM, EDAX, XRD, BET, Zeta potential, and FTIR techniques. The BET analysis revealed a specific surface area and total pore volume of 26.318 m²/g. SEM images confirmed the crystalline and spherical nature of the particles, with a particle size of 73.4 nm. A photoreactor was designed …

Dynamic Graph Enhanced Contrastive Learning For Chest X-Ray Report Generation, Mingjie Li, Bingqian Lin, Zicong Chen, Haokun Lin, Xiaodan Liang, Xiaojun Chang

Computer Vision Faculty Publications

Automatic radiology reporting has great clinical potential to relieve radiologists from heavy workloads and improve diagnosis interpretation. Recently, researchers have enhanced data-driven neural networks with medical knowledge graphs to eliminate the severe visual and textual bias in this task. The structures of such graphs are exploited by using the clinical dependencies formed by the disease topic tags via general knowledge and usually do not update during the training process. Consequently, the fixed graphs can not guarantee the most appropriate scope of knowledge and limit the effectiveness. To address the limitation, we propose a knowledge graph with Dynamic structure and nodes …

Editorial: Influence Of Sleep And Recurrent Circadian Disruption On Cardiometabolic Health, Wellbeing, And Safety: From Shiftwork To Monday Mornings, Philip Cheng, Dorothee Fischer, Dayna A. Johnson, Andrew W. Mchill

Sleep Medicine Articles

No abstract provided.

Novel Anti-Melanoma Compounds Are Efficacious In A375 Cell Line Xenograft Melanoma Model In Nude Mice, Sadeeshkumar Velayutham, Ryan Seerattan, Maab Khalid Sultan, Trisha Sea, Samaya Danthurthy, Baskaran Chinnappan, Jessica Landi, Kaitlyn Pearl, Aveta Singh, Keiran S. M. Smalley, Julia Zaias, Jun Yong Choi, Dmitriy Minond

HPD Articles

Despite the successes of immunotherapy, melanoma remains one of the deadliest cancers, therefore, the need for innovation remains high. We previously reported anti-melanoma compounds that work by downregulating spliceosomal proteins hnRNPH1 and H2. In a separate study, we reported that these compounds were non-toxic to Balb/C mice at 50 mg/kg suggesting their utility in in vivo studies. In the present study, we aimed to assess the efficacy of these compounds by testing them in A375 cell-line xenograft in nude athymic mice. Animals were randomized into four groups (n = 12/group): 10 mg/kg vemurafenib, and 25 mg/kg 2155-14 and 2155-18 thrice …

Gwu Senior And Alumnus Intern With Shelby, N.C., Podiatrists, Office Of University Communications

Gardner-Webb NewsCenter Archive

Every semester, many faculty members at Gardner-Webb University ask professionals to visit their classes to highlight various career opportunities. One of the guests invited by instructor of biology Stacie Smith is Dr. Gretchen A. Lawrence, a podiatrist with Foothills Podiatry PA in Shelby, N.C.

Focused Ultrasound-Mediated Brain Genome Editing., Yeh-Hsing Lao, Robin Ji, Joyce K Zhou, Kathy J. Snow, Nancy Kwon, Ethan Saville, Siyu He, Shradha Chauhan, Chun-Wei Chi, Malika S Datta, Hairong Zhang, Chai Hoon Quek, S Sarah Cai, Mingqiang Li, Yaned Gaitan, Lawrence Bechtel, Shih-Ying Wu, Cathleen Lutz, Raju Tomer, Stephen A Murray, Alejandro Chavez, Elisa E Konofagou, Kam W Leong

Faculty Research 2023

Gene editing in the brain has been challenging because of the restricted transport imposed by the blood-brain barrier (BBB). Current approaches mainly rely on local injection to bypass the BBB. However, such administration is highly invasive and not amenable to treating certain delicate regions of the brain. We demonstrate a safe and effective gene editing technique by using focused ultrasound (FUS) to transiently open the BBB for the transport of intravenously delivered CRISPR/Cas9 machinery to the brain.

Biomass Smoke Inhalation Promotes Neuroinflammatory And Metabolomic Temporal Changes In The Hippocampus Of Female Mice, David Scieszka, Yan Jin, Shahani Noor, Ed Barr, Marcus Garcia, Jessica Begay, Guy Herbert, Russell P. Hunter, Kiran Bhaskar, Rahul Kumar, Rama Gullapalli, Alicia Bolt, Mark A. Mccormick, Barry Bleske, Haiwei Gu, Matthew J. Campen

Pathology Research and Scholarship

Smoke from wildland fires has been shown to produce neuroinflammation in preclinical models, characterized by neural infiltrations of neutrophils and monocytes, as well as altered neurovascular endothelial phenotypes. To address the longevity of such outcomes, the present study examined the temporal dynamics of neuroinflammation and metabolomics after inhalation exposures from biomass-derived smoke. 2-month-old female C57BL/6 J mice were exposed to wood smoke every other day for 2 weeks at an average exposure concentration of 0.5 mg/m

Sociocultural Factors Associated With Persistent Prescription Opioid Use (Ppou) Among Puerto Rican Adults In Massachusetts, Inyene E. Essien-Aleksi, Yuan Zhang, Ainat Koren, Natalia Palacios, Luis M. Falcon, Katherine L. Tucker

Health Sciences Faculty Publications

Background: Increasing numbers of opioid-overdose deaths have been witnessed among Hispanics and other underserved populations in Massachusetts. Puerto Rican adults (PRs) have a disproportionately higher prevalence of chronic diseases than non-Hispanic White adults-conditions linked to increased prescription opioid use and misuse. Stress indicators, including low acculturation, low social support, and perceived discrimination, have been recognized as correlates of chronic diseases. However, little research has been undertaken on how these socio-cultural factors relate to persistent prescription opioid use among PRs. This study evaluated the prevalence of prescription opioid use and socio-cultural factors associated with persistent prescription opioid use among PRs.

Methods: …

August 22, 2023 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Nanoparticles For Treatment Of Posterior Segment Ocular Diseases And Conditions, Kathleen Emily-Ann Halasz, Yashwant V. Pathak, Vijaykumar Bhadabhai Sutariya

USF Patents

The present invention concerns nanoparticles useful for treating posterior segment ocular diseases or conditions, such as macular degeneration and diabetic retinopathy; compositions comprising the nanoparticles; methods for producing the nanoparticles; and methods for treating posterior segment ocular diseases or conditions, comprising administering the nanoparticles or compositions to the ocular posterior segment of an afflicted eye.

About Premedical Programs At Ud, Udayton

Pre-Health Resource Center Campus Communications

No abstract provided.

Elements Of Creative Writing, Grant Tracey, Rachel Morgan, Jeremy Schraffenberger

Faculty Book Gallery

This free and open access textbook introduces new writers to some basic elements of the craft of creative writing. The authors—Rachel Morgan, Jeremy Schraffenberger, and Grant Tracey—are editors of the North American Review, the oldest and one of the most well-regarded literary magazines in the United States. We’ve selected nearly all of our readings and examples from writing that has appeared in our pages over the years. Because we had a hand in publishing these pieces originally, our perspective as editors permeates this book. As such, we hope that even seasoned writers might gain insight into the aesthetics of our …

Role Of Ripk3 In The Pathogenesis Of Tet2 Mutant Hematopoietic Malignancies, Kanak Joshi

Dissertations

Hematopoiesis is dynamically controlled by an epigenetic landscape that regulates gene transcription. Ten-eleven translocation 2 (TET2) is a Fe2+ and α-ketoglutarate (α-KG)-dependent dioxygenase that regulates the transcriptional status of genes associated with hematopoietic stem cell self-renewal and multiple stages of lineage commitment and differentiation. TET2 mutations are commonly detected in almost all types of hematopoietic malignancies, including myeloproliferative disorder, acute myeloid leukemia, and peripheral T-cell lymphomas. In most cases, TET2 is a founder mutation that occurred in hematopoietic stem/progenitor cells (HSPCs). The mutant HSCs undergo clonal expansion and evolution with the accumulation of additional mutations for malignant transformation. Microbial-stimulated inflammatory …

How I Read An Article That Uses Machine Learning Methods, Aziz Nazha, Olivier Elemento, Shannon Mcweeney, Moses Miles, Torsten Haferlach

Kimmel Cancer Center Faculty Papers

No abstract provided.

Initial Experience With An Electron Flash Research Extension (Flex) For The Clinac System, Kyuhak Oh, Kyle J. Gallagher, Megan Hyun, Diane Schott, Sarah Wisnoskie, Yu Lei, Samuel Hendley, Jeffrey Wong, Shuo Wang, Brendan Graff, Christopher Jenkins, Frank Rutar, Md Ahmed, Joshua Mcneur, Jeffrey Taylor, Marty Schmidt, Lasitha Senadheera, Wendy Smith, Subodh M. Lele, Ran Dai, Dong Jianghu (James), Y Yan, Su-Min Zhou

Department of Physics and Astronomy: Faculty Publications

Purpose: Radiotherapy delivered at ultra-high-dose-rates (≥40 Gy/s), that is, FLASH, has the potential to effectively widen the therapeutic window and considerably improve the care of cancer patients. The underlying mechanism of the FLASH effect is not well understood, and commercial systems capable of delivering such dose rates are scarce. The purpose of this study was to perform the initial acceptance and commissioning tests of an electron FLASH research product for preclinical studies.

Methods: A linear accelerator (Clinac 23EX) was modified to include a nonclinical FLASH research extension (the Clinac-FLEX system) by Varian, a Siemens Healthineers company (Palo Alto, …

2007 Great Day Program, Suny Geneseo

GREAT Day Programs

SUNY Geneseo’s First Annual G.R.E.A.T. Day.