Digital Commons Network^™

Celebrating Leeuwenhoek’S Life 300 Years Later, Alan L. Gillen

Faculty Publications and Presentations

Antony van Leeuwenhoek entered eternity 300 years ago (August 26, 1723). He made hundreds of discoveries with his simple microscope. Perhaps his most notable discovery was of bacteria and its many shapes. He found great joy in God [http://answersingenesis.org/god/] ’s smallest creatures. I believe that his curiosity about the world, fueled by his belief in biblical creation [http://answersingenesis.org/creation/] , led to his discovery of bacteria. In a similar manner, his curiosity of blood led to his discovery of red corpuscles and capillaries. He remained a curious man until the last days of his life 300 years …

Transferrin-Targeted Liposomes In Glioblastoma Therapy: A Review, Paul Kawak, Nour M Al Sawaftah, William G. Pitt, Ghaleb A. Husseini

Faculty Publications

Glioblastoma (GBM) is a highly aggressive brain tumor, and its treatment is further complicated by the high selectivity of the blood–brain barrier (BBB). The scientific community is urgently seeking innovative and effective therapeutic solutions. Liposomes are a promising new tool that has shown potential in addressing the limitations of chemotherapy, such as poor bioavailability and toxicity to healthy cells. However, passive targeting strategies based solely on the physicochemical properties of liposomes have proven ineffective due to a lack of tissue specificity. Accordingly, the upregulation of transferrin receptors (TfRs) in brain tissue has led to the development of TfR-targeted anticancer therapeutics. …

The Influences Of Acculturative Stress And Gender Roles On Sexual Subjectivity In European, Asian, And Latinx Immigrant Women In The U.S., Silvia Re

Seton Hall University Dissertations and Theses (ETDs)

In the process of acculturation, cisgender immigrant women are at greater risk of experiencing acculturative stress, often entailing a reconsideration of their self-concepts and identities as members of new sociocultural contexts. Gender roles and sexual subjectivity are two identity features they can revise given their ties to culture and socialization. Results from previous studies suggest that cisgender immigrant women’s sociocultural contexts, related values, and attitudes may contribute to their levels of stress, sense of self-efficacy, self-esteem, and sexual subjectivity. This study aimed to fill gaps in the existing literature and raised awareness of the relationship between acculturative stress, gender role …

The Histone Chaperone Function Of Daxx Is Dispensable For Embryonic Development, Chang Sun, Yuan Qi, Natalie Fowlkes, Nina Lazic, Xiaoping Su, Guillermina Lozano, Amanda R Wasylishen

Faculty, Staff and Student Publications

Daxx functions as a histone chaperone for the histone H3 variant, H3.3, and is essential for embryonic development. Daxx interacts with Atrx to form a protein complex that deposits H3.3 into heterochromatic regions of the genome, including centromeres, telomeres, and repeat loci. To advance our understanding of histone chaperone activity in vivo, we developed two Daxx mutant alleles in the mouse germline, which abolish the interactions between Daxx and Atrx (DaxxY130A), and Daxx and H3.3 (DaxxS226A). We found that the interaction between Daxx and Atrx is dispensable for viability; mice are born at the …

Practical Diagnosis Of Cirrhosis In Non-Alcoholic Fatty Liver Disease Using Currently Available Non-Invasive Fibrosis Tests, J Boursier, Marine Roux, Charlotte Costentin, Julien Chaigneau, Céline Fournier-Poizat, Aldo Trylesinski, Cm Canivet, Sophie Michalak, Bail B Le, Valérie Paradis, Pierre Bedossa, Nathalie Sturm, Ledinghen V De, Justine Barthelon, J Boursier, Paul Cales, C Canivet, Thomas Decaens, Adèle Delamarre, Paul Hermabessiere, Marie Irles-Depé, Ledinghen V De, Marie Noelle Hilleret, Isabelle Fouchard-Hubert, Adrien Lannes, Bail B Le, Valérie Moal, Fréderic Oberti, Michael Allison, Peter J. Eddowes, Jeremy F. Cobbold, Jonathan J. Deeks, Peter J. Eddowes, Indra N. Guha, David Sheridan, Emmanuel Tsochatzis, Philip N. Newsome

Peninsula Medical School

Unlike for advanced liver fibrosis, the practical rules for the early non-invasive diagnosis of cirrhosis in NAFLD remain not well defined. Here, we report the derivation and validation of a stepwise diagnostic algorithm in 1568 patients with NAFLD and liver biopsy coming from four independent cohorts. The study algorithm, using first the elastography-based tests Agile3+ and Agile4 and then the specialized blood tests FibroMeterV3G and CirrhoMeterV3G, provides stratification in four groups, the last of which is enriched in cirrhosis (71% prevalence in the validation set). A risk prediction chart is also derived to allow estimation of the individual probability of …

A Non-Coding Insertional Mutation Of Grhl2 Causes Gene Over-Expression And Multiple Structural Anomalies Including Cleft Palate, Spina Bifida And Encephalocele, Zoe Crane-Smith, Sandra C P De Castro, Evanthia Nikolopoulou, Paul Wolujewicz, Damian Smedley, Yunping Lei, Emma Mather, Chloe Santos, Mark Hopkinson, Andrew A Pitsillides, Richard H Finnell, M Elisabeth Ross, Andrew J Copp, Nicholas D E Greene

Faculty, Staff and Students Publications

Orofacial clefts, including cleft lip and palate (CL/P) and neural tube defects (NTDs) are among the most common congenital anomalies, but knowledge of the genetic basis of these conditions remains incomplete. The extent to which genetic risk factors are shared between CL/P, NTDs and related anomalies is also unclear. While identification of causative genes has largely focused on coding and loss of function mutations, it is hypothesized that regulatory mutations account for a portion of the unidentified heritability. We found that excess expression of Grainyhead-like 2 (Grhl2) causes not only spinal NTDs in Axial defects (Axd) mice but also multiple …

Volume 15, Issue 1

Medical Muse

No abstract provided.

Proceedings From The Third Annual Society For Neurosports Conference, Neurosports Editorial Staff

Journal for Sports Neuroscience

Proceedings from the Third Annual Society for NeuroSports Conference

New Faculty Guide, 2023-2024, University Of Mississippi. Provost

New Faculty

No abstract provided.

Decision Making In Patients With Initial Positive Deep Margins On Diagnostic Biopsy Of Melanoma, Ana Eliza Souza Cunha

Yale School of Medicine Physician Associate Program Theses

Background: Current guidelines recommend SLN biopsy (SLNB) among patients with initial Breslow Thickness (BRES) ≥0.8mm at initial screening. However, there is limited guidance regarding SLNB among patients who have deeper final depth after initial biopsy.

Methods: We conducted a retrospective cohort study of 62 thin melanoma patients with primary lesions with initial Breslow Thickness (BRES)

Results: Approximately 55% of patients (n = 34) included in our study underwent SLNB. After adjustment, there was no association between SLNB status and recurrence. Immunosuppressive drug use was associated with higher odds of local (OR= 28.56 CI 1.87- 435.53; p =0.016) and regional recurrence …

Differences In Predicted Risk Of Mortality After Coronary Artery Bypass Graft Between Black And White Patients With Identical Clinical Profiles Using The Society Of Thoracic Surgeons Calculator: An In-Silico Cohort Study, Kiara Marmolejos

Yale School of Medicine Physician Associate Program Theses

Abstract/Summary:

Background: “The Society of Thoracic Surgeons mortality risk calculator”, which includes a race variable, is recommended for estimating Short- term (30 day) predicted risk of mortality after isolated coronary artery bypass graft, with a risk estimate of 3-4% stratifying patients into intermediate risk, a risk estimate above 5% stratifying patients into high risk for surgery and a risk estimate above 8% stratifying patients into the very high-risk category. We compared differences between Black and White individuals in Society of Thoracic Surgeons-predicted risk of mortality across various plausible risk factor combinations with the aim of evaluating if using the predictive …

2008 Great Day Program, State University Of New York At Geneseo

GREAT Day Programs

SUNY Geneseo’s Second Annual GREAT Day.

2009 Great Day Program, State University Of New York At Geneseo

GREAT Day Programs

SUNY Geneseo’s Third Annual GREAT Day.

2012 Great Day Program, State University Of New York At Geneseo

GREAT Day Programs

SUNY Geneseo’s Sixth Annual GREAT Day.

2015 Great Day Program, State University Of New York At Geneseo

GREAT Day Programs

SUNY Geneseo’s Ninth Annual GREAT Day.

2016 Great Day Program, State University Of New York At Geneseo

GREAT Day Programs

SUNY Geneseo’s Tenth Annual GREAT Day.

2017 Great Day Program, State University Of New York At Geneseo

GREAT Day Programs

SUNY Geneseo’s Eleventh Annual GREAT Day.

2020 Great Day Program, State University Of New York At Geneseo

GREAT Day Programs

SUNY Geneseo’s Fourteenth Annual GREAT Day.

2021 Great Day Program, State University Of New York At Geneseo

GREAT Day Programs

SUNY Geneseo’s Fifteenth Annual GREAT Day.

2022 Great Day Program, State University Of New York At Geneseo

GREAT Day Programs

SUNY Geneseo’s Sixteenth Annual GREAT Day.

2023 Great Day Program, State University Of New York At Geneseo

GREAT Day Programs

SUNY Geneseo’s Seventeenth Annual GREAT Day. Geneseo Recognizing Excellence, Achievement & Talent Day is a college-wide symposium celebrating the creative and scholarly endeavors of our students. http://www.geneseo.edu/great_day

2023 Ursinus College Academic Convocation Program, Ursinus College

Academic Convocation Programs

This Ursinus College Academic Convocation program lists speakers and events for the opening of the 2023 academic year.

The Library & Generative Ai, Nat Gustafson-Sundell, Mark Mccullough

Library Services Publications

A demonstration of several AI tools, including ChatGPT, ChatPDF, Consensus, and more. The focus of the session is on potential student uses of the tools and related library initiatives, so we address the limits of ChatGPT as an information source. Librarians can help students learn how to use these tools responsibly and provide leadership on campus as AI is integrated into assignments.

Zilpha Snyder Collection Finding Aid, Paige Harris

Finding Aids

Zilpha Snyder was a 1948 alumna of Whittier College best known for her authorship of children's books, including The Egypt Game, The Headless Cupid, and The Witches of Worm. The Snyder Collection consists of copies of books she authored.

Anterior Chamber Depth In Mice Is Controlled By Several Quantitative Trait Loci, Demelza R. Larson, Allysa J. Kimber, Kacie J. Meyer, Michael G. Anderson

Biology Faculty Publications

Anterior chamber depth (ACD) is a quantitative trait associated with primary angle closure glaucoma (PACG). Although ACD is highly heritable, known genetic variations explain a small fraction of the phenotypic variability. The purpose of this study was to identify additional ACD-influencing loci using strains of mice. Cohorts of 86 N2 and 111 F2 mice were generated from crosses between recombinant inbred BXD24/TyJ and wild-derived CAST/EiJ mice. Using anterior chamber optical coherence tomography, mice were phenotyped at 10–12 weeks of age, genotyped based on 93 genome-wide SNPs, and subjected to quantitative trait locus (QTL) analysis. In an analysis of ACD among …

Impacts Of Pre-Existing Medical Conditions On Willingness To Pay For Fortified Rice In India, Adithya Sekhar Gummadi

Student Theses and Dissertations

The use of food fortification to combat nutrient deficiencies has garnered popularity as it has proven to be a cost-effective strategy to combat and prevent many diseases and illnesses associated with nutrient deficiencies. This research aimed to examine the willingness to pay (WTP) of Indian consumers for fortified food products predicated on the addition of the nutrients Iron, Zinc, Folic Acid, Vitamin A, and Vitamin B. Additionally, the impact of pre-existing medical conditions on overall willingness to pay is evaluated. This study finds that Indian consumers are willing to pay more for fortified products. A pre-existing medical condition's impact was …

Short-Term Vehicle Speed Prediction With Spatiotemporal Convolution Fused With Variational Modal Decomposition, Kai Zhang, Haipeng Lu, Ying Han, Lingyun Zhang, Yujie Ding

Journal of System Simulation

Abstract: Accurate short-term vehicle speed prediction helps to resolve city traffic congestion problems. Focusing on the defect that CNN cannot process non-Euclidean geometric data, GCN and BiLSTM are combined to fully process the spatiotemporal characteristics of road network information, in which the advantages of GCN integrating global features and the ability of BiLSTM to extract temporal features are considered. In order to reduce the interference of noise to the data, variational modal decomposition (VMD) is introduced and short-term vehicle speed prediction model based on VMD-GCN-BiLSTM (VGBLSTM) is proposed . Simulation results show that the prediction accuracy of VGBLSTM model is …

Resistant Potato Starch Supplementation Reduces Serum Histamine Levels In Healthy Adults With Links To Attenuated Intestinal Permeability, Jason R. Bush, Jun Han, Edward C. Deehan, Scott V. Harding, Madhura Maiya, Joshua Baisley, David Schibli, David R. Goodlett

Department of Nutrition and Health Sciences: Faculty Publications

Histamine from our diet or gut microbes can trigger gastrointestinal disturbances, and resistant potato starch (RPS) has previously been shown to alleviate these symptoms while increasing levels of health-associated bacteria such as Akkermansia through unknown mechanisms. Post hoc exploratory metabolomic analysis of serum amino acid, amine, and carnitine metabolites in participants consuming 3.5 g/day RPS or placebo (n = 48) was performed using liquid chromatography-mass spectrometry to determine whether RPS positively influences histamine metabolism and related parameters. Histamine levels were significantly reduced by RPS treatment, but histamine-degrading enzyme products were unaffected by RPS. RPS also reduced histamine-secreting Haemophilus and Lactobacillus …

2023-08-25, Board Of Regents, Murray State University

Board of Regents Meeting Minutes

No abstract provided.

Heterogeneity In Macrophages Along The Cochlear Spiral In Mice: Insights From Sem And Functional Analyses, Celia Zhang, Mengxiao Ye, Peter Bush, Bo Hua Hu

Pacific Faculty Work

The susceptibility of sensory cells to pathological conditions differs between the apical and basal regions of the cochlea, and the cochlear immune system may contribute to this location-dependent variability. Our previous study found morphological differences in basilar membrane macrophages between the apical and basal regions of the cochlea. However, the details of this site-dependent difference and its underlying structural and biological basis are not fully understood. In this study, we utilized scanning electron microscopy to examine the ultrastructure of macrophages and their surrounding supporting structures. Additionally, we examined the phagocytic activities of macrophages and the expression of immune molecules in …