Digital Commons Network^™

Cobimetinib Plus Vemurafenib In Patients With Solid Tumors With Braf Mutations: Results From The Targeted Agent And Profiling Utilization Registry Study, Funda Meric-Bernstam, Michael Rothe, Pam K Mangat, Elizabeth Garrett-Mayer, Rodolfo Gutierrez, Eugene R Ahn, Timothy L Cannon, Steven Powell, John C Krauss, Christopher M Reynolds, Margaret Von Mehren, Deepti Behl, Carmen J Calfa, Herbert L Duvivier, Henry G Kaplan, Michael B Livingston, Manish R Sharma, Walter J Urba, Gina N Grantham, Dominique C Hinshaw, Abigail Gregory, Susan Halabi, Richard L Schilsky

Faculty, Staff and Student Publications

Purpose: The Targeted Agent and Profiling Utilization Registry Study is a phase II basket study evaluating antitumor activity of commercially available targeted agents in patients with advanced cancers with genomic alterations known to be drug targets. The results in a cohort of patients with solid tumors with BRAF mutations treated with cobimetinib plus vemurafenib are reported.

Methods: Eligible patients had measurable disease (RECIST v.1.1), Eastern Cooperative Oncology Group performance status 0-2, adequate organ function, and no standard treatment options. The primary end point was disease control (DC), defined as complete response (CR) or partial response (PR) or stable disease of …

Parental Diabetes Distress Is A Stronger Predictor Of Child Hba1c Than Diabetes Device Use In School-Age Children With Type 1 Diabetes., Susana R. Patton, Nicole Kahhan, Jessica S. Pierce, Matthew Benson, Larry A. Fox, Mark A. Clements

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Diabetes distress (DD) describes the unrelenting emotional and behavioral challenges of living with, and caring for someone living with, type 1 diabetes (T1D). We investigated associations between parent-reported and child-reported DD, T1D device use, and child glycated hemoglobin (HbA1c) in 157 families of school-age children.

RESEARCH DESIGN AND METHODS: Parents completed the Parent Problem Areas in Diabetes-Child (PPAID-C) and children completed the Problem Areas in Diabetes-Child (PAID-C) to assess for DD levels. Parents also completed a demographic form where they reported current insulin pump or continuous glucose monitor (CGM) use (ie, user/non-user). We measured child HbA1c using a valid …

Bame Directly Interacts With Bama And Bamd Coordinating Their Functions, Santosh Kumar, Anna Konovalova

Faculty, Staff and Student Publications

The β-barrel assembly machinery (Bam) complex facilitates the assembly of outer membrane proteins (OMPs) in gram-negative bacteria. The Bam complex is conserved and essential for bacterial viability and consists of five subunits, BamA-E. BamA is the transmembrane component, and its β-barrel domain opens laterally to allow folding and insertion of incoming OMPs. The remaining components are regulatory, among which only BamD is essential. Previous studies suggested that BamB regulates BamA directly, while BamE and BamC serve as BamD regulators. However, specific molecular details of their functions remain unknown. Our previous research demonstrated that BamE plays a specialized role in assembling …

Multiplatform Analysis Of Intratumoral Pten Heterogeneity In Melanoma, Sharmeen Chagani, Mariana P De Macedo, Fernando Carapeto, Feng Wang, Diego M Marzese, Khalida Wani, Lauren E Haydu, Weiyi Peng, Giang T Ong, Sarah E Warren, Joseph M Beechem, Dave S B Hoon, Gordon B Mills, Michael T Tetzlaff, Alexander J Lazar, Lawrence N Kwong, Michael A Davies

Faculty, Staff and Student Publications

Loss of protein expression of the tumor suppressor PTEN is associated with increased cancer aggressiveness, decreased tumor immune infiltration, and resistance to immune and targeted therapies in melanoma. We assessed a unique cohort of eight melanoma samples with focal loss of PTEN protein expression to understand the features and mechanisms of PTEN loss in this disease. We compared the PTEN-negative (PTEN[-]) areas to their adjacent PTEN-positive (PTEN[+]) areas using DNA sequencing, DNA methylation, RNA expression, digital spatial profiling, and immunohistochemical platforms. Variations or homozygous deletions of PTEN were identified in PTEN(-) areas that were not detected in the adjacent PTEN(+) …

Inhibition Of The Interaction Between Hippo/Yap And Akt Signaling With Ursolic Acid And 3’3-Diindolylmethane Suppresses Esophageal Cancer Tumorigenesis, Ruo Yu Meng, Cong Shan Li, Dan Hu, Soon-Gu Kwon, Hua Jin, Ok Hee Chai, Ju-Seog Lee, Soo Mi Kim

Faculty, Staff and Student Publications

Hippo/YAP signaling hinders cancer progression. Inactivation of this pathway contributes to the development of esophageal cancer by activation of Akt. However, the possible interaction between Akt and Hippo/YAP pathways in esophageal cancer progression is unclear. In this study, we found that ursolic acid (UA) plus 3'3-diindolylmethane (DIM) efficiently suppressed the oncogenic Akt/Gsk-3β signaling pathway while activating the Hippo tumor suppressor pathway in esophageal cancer cells. Moreover, the addition of the Akt inhibitor LY294002 and the PI3K inhibitor 3-methyladenine enhanced the inhibitory effects of UA plus DIM on Akt pathway activation and further stimulated the Hippo pathway, including the suppression of …

Inorganic Fertilizer Use And Its Association With Rice Yield Gaps In Sub-Saharan Africa, Jean-Martial Johnson, Ali Ibrahim, Elliott Ronald Dossou-Yovo, Kalimuthu Senthilkumar, Yasuhiro Tsujimoto, Hidetoshi Asai, Kazuki Saito

Faculty, Staff and Student Publications

Where and which countries should receive higher priority for improving inorganic fertilizer use in rice fields in sub-Saharan Africa (SSA)? This study addressed this question by assessing the spatial variation in fertilizer use and its association with rice yield and yield gap in 24 SSA countries through a systematic literature review of peer-reviewed papers, theses, and grey literature published between 1995 and 2021. The results showed a large variation in N, P, and K fertilizer application rates and rice yield and an opportunity for narrowing the yield gap by increasing N and P rates, especially in irrigated rice systems. We …

Low Pitch Significantly Reduces Helical Artifacts In Abdominal Ct, Moiz Ahmad, Peng Sun, Christine B Peterson, Marcus R Anderson, Xinming Liu, Ajaykumar C Morani, Corey T Jensen

Faculty, Staff and Student Publications

Purpose: High helical pitch scanning minimizes scan times in CT imaging, and thus also minimizes motion artifact and mis-synchronization with contrast bolus. However, high pitch produces helical artifacts that may adversely affect diagnostic image quality. This study aims to determine the severity and incidence of helical artifacts in abdominal CT imaging and their relation to the helical pitch scan parameter.

Methods: To obtain a dataset with varying pitch values, we used CT exam data both internal and external to our center. A cohort of 59 consecutive adult patients receiving an abdomen CT examination at our center with an accompanying prior …

Temporal Characterization Of Acute Pain And Toxicity Kinetics During Radiation Therapy For Head And Neck Cancer A Retrospective Study, Vivian Salama, Sara Youssef, Tianlin Xu, Kareem A Wahid, Jaime Chen, Jillian Rigert, Anna Lee, Katherine A Hutcheson, Brandon Gunn, Jack Phan, Adam S Garden, Steven J Frank, William Morrison, Jay P Reddy, Michael T Spiotto, Mohamed A Naser, Cem Dede, Renjie He, Abdallah S R Mohamed, Lisanne V Van Dijk, Ruitao Lin, Carlos J Roldan, David I Rosenthal, Clifton D Fuller, Amy C Moreno, Md Anderson Head And Neck Cancer Symptom Working Group

Faculty, Staff and Student Publications

OBJECTIVES: Pain during Radiation Therapy (RT) for oral cavity/oropharyngeal cancer (OC/OPC) is a clinical challenge due to its multifactorial etiology and variable management. The objective of this study was to define complex pain profiles through temporal characterization of pain descriptors, physiologic state, and RT-induced toxicities for pain trajectories understanding.

MATERIALS AND METHODS: Using an electronic health record registry, 351 OC/OPC patients treated with RT from 2013 to 2021 were included. Weekly numeric scale pain scores, pain descriptors, vital signs, physician-reported toxicities, and analgesics were analyzed using linear mixed effect models and Spearman's correlation. Area under the pain curve (AUC

RESULTS: …

Biob 161n.00: Principles Of Living Systems Lab, Harris Sloan

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Biom 427.01: General Parasitology, Christopher S. Peterson

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Biom 360.01: General Microbiology, Michael F. Minnick

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Biob 101n.50: Discover Biology - Online, Andrea T. Green

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Stromal-Derived Nrg1 Enables Oncogenic Kras Bypass In Pancreas Cancer, Jincheng Han, Jiaqian Xu, Yonghong Liu, Shaoheng Liang, Kyle A Labella, Deepavali Chakravarti, Denise J Spring, Yan Xia, Ronald A Depinho

Faculty, Staff and Student Publications

Activating KRAS mutations (KRAS*) in pancreatic ductal adenocarcinoma (PDAC) drive anabolic metabolism and support tumor maintenance. KRAS* inhibitors show initial antitumor activity followed by recurrence due to cancer cell-intrinsic and immune-mediated paracrine mechanisms. Here, we explored the potential role of cancer-associated fibroblasts (CAFs) in enabling KRAS* bypass and identified CAF-derived NRG1 activation of cancer cell ERBB2 and ERBB3 receptor tyrosine kinases as a mechanism by which KRAS*-independent growth is supported. Genetic extinction or pharmacological inhibition of KRAS* resulted in up-regulation of ERBB2 and ERBB3 expression in human and murine models, which prompted cancer cell utilization of CAF-derived NRG1 as a …

Chronic Illness Education 2023: Misconceptions Surrounding Adult Obesity With Targeted Educational Materials, Andrew Lemmen, Shrila Rajendran, Daniel Saxon, Devun Birk, Timothy Li, Pooja Polamarasetti

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: From Playtime To Prevention: Innovative Approaches For Promoting Cardiovascular Health In Children, Isabella Anton, Parnia Behinaein, Patrick Kollman, Yage Pi, Samy Shelbaya, Jacob Waitzman, Dhruvil Patel

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Optimizing Parenting Strategies To Reduce The Probability Of Separation Anxiety Development, Neil Garg, Sara Naessig, Sohini Pandit, Meet Patel, Lara Rostomian, Dhiraj Tadikamalla, Alyssa Kalsbeek

Patient Education Projects

No abstract provided.

Toe-Pad Length And Body Mass Are Reliable Indicators Of Sex In Barred Owls, Hermary M. Gonzales, Daniel F. Hofstader, Whitney A. Watson

North American Bird Bander

No abstract provided.

The Interesting Story Of The Oldest Known Gray Hawk, William S. Clark, Michael T. Stewart

North American Bird Bander

No abstract provided.

A Fast-Traveling, Fall-Migrating Hummingbird, Vernon Kleen, James Renfro

North American Bird Bander

No abstract provided.

Activation Of Cell-Free Mtdna-Tlr9 Signaling Mediates Chronic Stress-Induced Social Behavior Deficits, Ashutosh Tripathi, Alona Bartosh, Carl Whitehead, Anilkumar Pillai

Faculty, Staff and Student Publications

Inflammation and social behavior deficits are associated with a number of neuropsychiatric disorders. Chronic stress, a major risk factor for depression and other mental health conditions is known to increase inflammatory responses and social behavior impairments. Disturbances in mitochondria function have been found in chronic stress conditions, however the mechanisms that link mitochondrial dysfunction to stress-induced social behavior deficits are not well understood. In this study, we found that chronic restraint stress (RS) induces significant increases in serum cell-free mitochondrial DNA (cf-mtDNA) levels in mice, and systemic Deoxyribonuclease I (DNase I) treatment attenuated RS-induced social behavioral deficits. Our findings revealed …

Clinical Outcomes Of Rotator Cuff Repair With Subacromial Bursa Reimplantation: A Retrospective Cohort Study, James M Gregory, Cristian Ybarra, Zean Liao, Manickam Kumaravel, Saagar Patel, Ryan J Warth

Faculty, Staff and Student Publications

BACKGROUND: The subacromial bursa has been found to be a rich, local, source of mesenchymal stem cells but is removed for visualization during rotator cuff repair. Reimplantation of this tissue may improve rotator cuff healing. The purpose of this study is to evaluate clinical outcomes of rotator cuff repair with and without subacromial bursa reimplantation.

METHODS: Patients aged 37-77 with a full-thickness or near full-thickness supraspinatus tears underwent arthroscopic transosseous-equivalent double row rotator cuff repair. In patients prior to July 2019, the subacromial bursa was resected for visualization, and discarded. In patients after July 2019, the subacromial bursa was collected …

Take Back The Power: The Fall And Rise And Fall Of New York City's Transport Workers Union Local 100, 1975–2009, Marc Kagan

Dissertations, Theses, and Capstone Projects

Take Back the Power: The Fall and Rise and Fall of Transport Workers Union Local 100, 1975-2009 tracks the history of this strategically significant union from the onset of New York City’s fiscal crisis in 1975 to the end, in 2009, of a second attempt to free transit workers from the grip of neoliberal economic austerity.

The first effort began in 1978 and culminated with the eleven-day 1980 transit strike, initiated by union dissidents over the opposition of the union president, but abruptly ended by him before a decisive victory could be won. That president, and his successors, reconciled themselves …

Pre-Clinical Evaluation Of A Potential Ruthenium-Based Chemotherapeutic Agent For The Treatment Of Triple Negative Breast Cancer, Nazia Nayeem

Dissertations, Theses, and Capstone Projects

Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer that represents roughly 15% of all diagnosed breast cancers. TNBC is defined by the absence of expression of progesterone, estrogen, and human epidermal growth factor 2 receptors, and has a higher incidence rate in pre-menopausal women and women of African and of Hispanic ancestry. Due to the inability to target a receptor, treatment is limited to nonspecific chemotherapy or immunotherapy. Only one FDA approved therapy is available specifically to treat TNBC, which is antibody drug conjugate Sacitzumab-govitecan, given to patients who have already gone through two rounds of …

Prescription Drug Misuse In Racial And Ethnic Minorities: Prevalence And Predictors, Valerie Watts

Loma Linda University Electronic Theses, Dissertations & Projects

The United States (U.S.) is currently facing a complex epidemic of prescription drug misuse (PDM). Previous literature lacks information on the prevalence of PDM in racial and ethnic minorities (REM) and associated precipitating variables. The current review aims to build upon the limited research regarding REM engagement in PDM and the associated variables. This examination identified and summarized: 1) contemporary research on the prevalence of PDM in REM, 2) major variables associated with PDM in this subpopulation, and 3) current evidence-based treatments for PDM. The review revealed mixed results related to the prevalence of PDM in REM. Previous research believed …

“I Passed First-Year Writing—What Now?” Adapting Strategies From First-Year Writing To Writing In The Disciplines, Amy T. Cicchino

Publications

This chapter foreshadows challenges you can experience as you adapt your writing beyond your first-year writing course to become a writer in your discipline.1 The essay contains a student scenario, defines key rhetorical concepts within discipline-specific writing situations, and gives you strategies for adapting these rhetorical concepts to new writing situations. After reading this chapter, you will better understand how the concepts introduced in first-year writing connect to the writing you will encounter in your upper-level, disciplinary courses and identify strategies that will help you intentionally adapt writing knowledge to new discipline-specific contexts.

A Multiproxy Approach To Deciphering The Geochemical Evolution Of Cold Seep Environments, Robert Seth Wood

Arts & Sciences Graduate Student Theses and Dissertations

The environmental and biological factors that influence the precipitation and composition of geologic proxies are often assumed to be minimally variable relative to the spatial and temporal domain of individual samples (ca. millimeters to centimeters). While this presumption may apply to many pelagic environments, it may not be appropriate for methane cold seep sites. Methane cold seeps are localized environments that can transport large quantities of dissolved methane - a potent greenhouse gas - toward the seafloor and, in turn, sustain high rates of anaerobic oxidation of methane by sulfate reduction (AOM-SR). The concurrent transport of anoxic seep fluids, diffused …

An Attempt At Fixing The Oversimplification Of Nightshades' (Genus Solanum) Epidermal Hair Complexity, Sakshi Watts, Rupesh Kariyat

Entomology and Plant Pathology Faculty Publications and Presentations

OPINION article

An attempt at fixing the oversimplification of Nightshades’ (genus Solanum) epidermal hair complexity

Agricultural Pesticide Regulatory Environment For Pollinator Protection Across Geographical Regions, Ngoc T. Phan, Edwin G. Rajotte, Guy Smagghe, Zong-Xin Ren, David J. Biddinger, Neelendra K. Joshi

Entomology and Plant Pathology Faculty Publications and Presentations

The alarming decline of pollinator populations has raised significant concerns worldwide and prompted the need for effective pesticide risk assessment within the Integrated Pest and Pollinator Management (IPPM) framework. This paper examines the diverse approaches to pollinator protection within the pesticide regulatory environments of the United States (US), the European Union (EU), and selected Asian countries. The US adopts a reactive approach, regulating pesticides only after evidence of harm emerges, while the EU embraces a proactive stance under the precautionary principle. The EU has implemented stringent regulations, including neonicotinoid bans, and conducts coordinated research on pesticide impacts. In contrast, some …

Strawberry Production Guide For The Northeast, Midwest, And Eastern Canada 2nd Edition, Rebecca Sideman, Kaitlyn Orde

UNH Cooperative Extension

This guide is intended as a comprehensive resource for both novice and experienced strawberry growers in northeastern North America. It provides information on all aspects of strawberry culture. The second edition has been updated and revised throughout, and includes expanded and new information on variety selection (Ch. 3), production systems (Ch. 4), harvesting, handling and transportation (Ch. 12), marketing (Ch. 13) and budgeting/economics (Ch. 14). In addition, a new section on diagnosing problems in strawberry plantings has been added (Ch. 15).

Degredation Of Organic Pollutants In Flocculated Liquid Digestate Using Photocatalytic Titanate Nanofibers: Mechanism And Response Surface Optimization, Yiting Xiao, Yang Tian, Yuanhang Zhan, Jun Zhu

Biological and Agricultural Engineering Faculty Publications and Presentations

Titanate nanofibers (TNFs) were synthesized using a hydrothermal method and were employed for the first time in this study to photocatalytically degrade organic pollutants found in flocculated liquid digestate of poultry litter. The photocatalytic performance of TNFs, with a bandgap of 3.16 eV, was tested based on degradation of organic pollutants and removal of color. Five combinations of pollutant concentration and pH were examined (0.2 to 1.3 g·L⁻¹ at pH 4 to 10). Central composite design (CCD) and response surface methodology (RSM) were applied in order to optimize the removal rates of volatile fatty acids (VFA) and chemical oxygen …