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Variable Light Penetration And Chlorophyll Concentrations From A Vertical Profiler In The Gulf Of Maine, With Implications For Remote Sensing And Ecosystem Modeling, Terence W. O'Brien

Master's Theses and Capstones

Variability in light field penetration into the ocean alters both radiant heat flux and oceanic primary production. Both are increasingly important in the context of quantifying biologically-mediated atmospheric carbon fluxes and sea surface temperature increase in a changing climate. Accurate determination of light penetration into the upper ocean depends upon accurate estimates of the depth-resolved water absorption and attenuation properties through the water column, properties that are often assumed homogeneous vertically and slowly variant in time. This thesis explores all-new Gulf of Maine datasets collected using a moored vertical profiler that provides sub-hourly light attenuation profiles with sub-m vertical resolution …

Rare Earth Element Distributions In Forest Soils Across Bedrock Gradients In New Hampshire And Vermont, Ashley Grengs

Master's Theses and Capstones

Within Earth surface systems, forests factor critically in carbon cycling and sequestration and accordingly play an important role in many climate change mitigation strategies. Predictive models of carbon storage require assessments of carbon storage as well as nutrient cycling, which, in turn, has long-term impacts on carbon storage. Nutrient allocations affect tree biomass, leaf growth, stem density, and biodiversity. Yet, bedrock contributions to nutrient allocations are not routinely quantified, even though bedrock compositions can influence soil types, soil pH, and tree species within forest.

Here, I expand on previously developed approaches to conduct a comparative study between eight sites across …

Evaluation Of A Wave Powered Water Pump Performance By Ocean Field Testing And Wec-Sim Modeling, Chelsea Kimball

Master's Theses and Capstones

A rising demand for macroalgae (or seaweed) has led researchers to seek out methods of increasing macroalgae aquaculture yields. Macroalgae is a food product, and may be used in biofuel, animal feed, and fertilizer. Applying upwelling technology to macroalgae aquaculture has been shown to increase biomass yield. A wave-powered upwelling device (or water pump) generates cold, nutrient-rich water flow to the surface of an aquaculture operation. A wave pump device developed at University of New Hampshire was refurbished and outfitted with instrumentation to determine its performance. Testing in the laboratory on both the device and instrumentation was conducted to prepare …

Generation Of Lexa Enhancer-Trap Lines In Drosophila By An International Scholastic Network, Cory J. Evans, Ella S. Kim, Arjun Rajan, Kathleen Chang, Sanath Govindarajan, Clara Gulick, Eva English, Bianca Rodriguez, Orion Bloomfield, Stella Nakada, Charlotte Beard, Sarah O’Connor, Sophia Mastroianni, Emma Downey, Matthew Feigenbaum, Caitlin Tolentino, Abigail Pace, Marina Khan, Soyoun Moon, Jordan Diprima, Amber Syed, Flora Lin, Yasmina Abukhadra, Isabella Bacon, John Beckerle, Sophia Cho, Nana Esi Donkor, Lucy Garberg, Ava Harrington, Mai Hoang, Nosa Lawani, Ayush Noori, Euwie Park

Biology Faculty Works

Conditional gene regulation in Drosophila through binary expression systems like the LexA-LexAop system provides a superb tool for investigating gene and tissue function. To increase the availability of defined LexA enhancer trap insertions, we present molecular, genetic, and tissue expression studies of 301 novel Stan-X LexA enhancer traps derived from mobilization of the index SX4 line. This includes insertions into distinct loci on the X, II, and III chromosomes that were not previously associated with enhancer traps or targeted LexA constructs, an insertion into ptc, and seventeen insertions into natural transposons. A subset of enhancer traps was expressed in …

Shoreline Oil Spill Response Knowledge Gaps And Technological Development Opportunities: A Workshop Report, Crrc, Noaa, Bsee

Coastal Response Research Center

The Bureau of Safety and Environmental Enforcement (BSEE) partnered with NOAA’s Office of Response and Restoration (OR&R) and UNH’s Coastal Response Research Center (CRRC) to plan and facilitate an in-person workshop on the NOAA WRC in Seattle, WA. This event entitled “Shoreline Oil Spill Response Knowledge Gaps and Technological Development Opportunities” identified knowledge gaps and opportunities regarding technologies and scientific research associated with oil spill shoreline response. This effort included the exploration of the current state of the science of oil spill research associated with impacts of crude oil to shoreline environments and identified countermeasures and response alternatives that may …

Acromegaly: Pathophysiological Considerations And Treatment Options Including The Evolving Role Of Oral Somatostatin Analogs, Charles P. Daniel, Maxwell J. Wagner, Grant E. Borne, Connor J. Plaisance, Shahab Ahmadzadeh, Alfonso Aquino, Sahar Shekoohi, Adam M. Kaye, Elyse M. Cornett, Alan D. Kaye

Pacific Faculty Work

Acromegaly is a condition most commonly diagnosed in the fifth decade of life and has numerous treatment options. In this regard, Mycapssa^® is the first FDA-approved oral octreotide capsule for treating acromegaly, combining the efficacy of the somatostatin receptor ligand, octreotide, with the ease of a twice-daily oral capsule. Where surgical treatment is not an option, somatostatin analogs, including octreotide, are the first line of medical treatment for acromegaly, requiring regular subcutaneous or intramuscular injections administered by a patient’s healthcare provider. Octreotide capsules (Mycapssa^®) provide an alternative to these somatostatin receptor ligand injections by combining octreotide with …

Anty 101h.01: Anthropology And The Human Experience - Introduction To Anthropology, David G. Kerr

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Anty 310.01: Human Variation, Meradeth H. Snow

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Chmy 124.00: Introduction To Organic And Biochemistry Lab, Brooke D. Martin

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Understanding The Experiences And Associated Symptomology Of Disclosers And Non-Disclosers Of Sexual Victimization, Kaitlin Carson

Dissertations, Theses, and Capstone Projects

ABSTRACT

According to the Center for Disease Control and Prevention, as many as 43% of women report experiencing some form of sexual victimization, with the highest rates occurring in emerging adulthood. It is estimated that 75% of survivors disclose this experience to someone else; the remainder of survivors keep the experience to themselves. While disclosure can be therapeutic, there are multiple factors that can complicate the disclosure process for sexual victimization survivors. There is limited research investigating why some women choose to disclose sexual victimization experiences and how their reasons may relate to psychopathology. Additionally, extant research primarily focuses on …

Electrophysiological Signatures Of Stress Adaptability In The Bnst-Vta Pathway, Yuka Miura

Dissertations, Theses, and Capstone Projects

Chronic stress has detrimental effects on psychological and physiological health. Incapability to adapt to chronic stress can lead to depression, anxiety disorders, and addiction. The brain regions critical for reward processing share diverse physiological and molecular changes linked to depressive-like behaviors as a result of chronic stress. Cumulative evidence shows that counteraction or prevention of these alterations in neurons, occasionally in a projection-specific manner, can enhance stress adaptation or resilience.

Chronic stress induces various changes in the brain, including in the bed nucleus of the stria terminalis (BNST) and the ventral tegmental area (VTA). The neural projections from the BNST …

A Lamprey Neural Cell Type Atlas Illuminates The Origins Of The Vertebrate Brain, Francesco Lamanna, Francisca Hervas-Sotomayor, A. Phillip Oel, David Jandzik, Daniel Sobrido-Cameán, Gabriel N. Santos-Durán, Megan L. Martik, Jan Stundl, Stephen A. Green, Thoomke Brüning, Katharina Mößinger, Julia Schmidt, Celine Schneider, Mari Sepp, Florent Murat, Jeramiah J. Smith, Marianne E. Bronner, María Celina Rodicio, Antón Barreiro-Iglesias, Daniel M. Medeiros, Detlev Arendt, Henrik Kaessmann

Markey Cancer Center Faculty Publications

The vertebrate brain emerged more than ~500 million years ago in common evolutionary ancestors. To systematically trace its cellular and molecular origins, we established a spatially resolved cell type atlas of the entire brain of the sea lamprey—a jawless species whose phylogenetic position affords the reconstruction of ancestral vertebrate traits—based on extensive single-cell RNA-seq and in situ sequencing data. Comparisons of this atlas to neural data from the mouse and other jawed vertebrates unveiled various shared features that enabled the reconstruction of cell types, tissue structures and gene expression programs of the ancestral vertebrate brain. However, our analyses also revealed …

Bacteroides Fragilis In The Gut Microbiomes Of Alzheimer’S Disease Activates Microglia And Triggers Pathogenesis In Neuronal C/Ebpβ Transgenic Mice, Yiyuan Xia, Yifan Xiao, Zi-Hao Wang, Ashfaqul M. Alam, John P. Haran, Beth A. Mccormick, Xiji Shu, Xiaochuan Wang, Keqiang Ye

Markey Cancer Center Faculty Publications

Gut dysbiosis contributes to Alzheimer’s disease (AD) pathogenesis, and Bacteroides strains are selectively elevated in AD gut microbiota. However, it remains unknown which Bacteroides species and how their metabolites trigger AD pathologies. Here we show that Bacteroides fragilis and their metabolites 12-hydroxy-heptadecatrienoic acid (12-HHTrE) and Prostaglandin E2 (PGE2) activate microglia and induce AD pathogenesis in neuronal C/EBPβ transgenic mice. Recolonization of antibiotics cocktail-pretreated Thy1-C/EBPβ transgenic mice with AD patient fecal samples elicits AD pathologies, associated with C/EBPβ/Asparaginyl endopeptidase (AEP) pathway upregulation, microglia activation, and cognitive disorders compared to mice receiving healthy donors’ fecal microbiota transplantation (FMT). Microbial 16S rRNA sequencing …

New Insights On The Differential Interaction Of Sulfiredoxin With Members Of The Peroxiredoxin Family Revealed By Protein-Protein Docking And Experimental Studies, Murli Mishra, Hong Jiang, Qiou Wei

Markey Cancer Center Faculty Publications

Sulfiredoxin (Srx) is the enzyme that restores the peroxidase activity of peroxiredoxins (Prxs) through catalyzing the reduction of hyperoxidized Prxs back to their active forms. This process involves protein-protein interaction in an enzyme-substrate binding manner. The integrity of the Srx-Prx axis contributes to the pathogenesis of various oxidative stress related human disorders including cancer, inflammation, cardiovascular and neurological diseases. The purpose of this study is to understand the structural and molecular biology of the Srx-Prx interaction, which may be of significance for prediction of target site for the novel drug-discovery. Homology modeling and protein-protein docking approaches were applied to examine …

Syne1 Mutation Is Associated With Increased Tumor Mutation Burden And Immune Cell Infiltration In Ovarian Cancer, Laura M. Harbin, Nan Lin, Frederick R. Ueland, Jill M. Kolesar

Markey Cancer Center Faculty Publications

SYNE1, a nuclear envelope protein critical for cellular structure and signaling, is downregulated in numerous malignancies. SYNE1 alterations are found in 10% of gynecologic malignancies and 5% of epithelial ovarian cancers. Previous studies demonstrated an association between SYNE1 mutation, increased tumor mutation burden (TMB), and immunotherapy response. This study evaluates the SYNE1 mutation frequency, association with TMB, and downstream effects of SYNE1 mutation in ovarian cancer. Genetic information, including whole-exome sequencing, RNA analysis, and somatic tumor testing, was obtained for consenting ovarian cancer patients at an academic medical center. Mutation frequencies were compared between the institutional cohort and The Cancer …

Unleashing The Potential Of 1,3-Diketone Analogues As Selective Lh2 Inhibitors, Juhoon Lee, Hou-Fu Guo, Shike Wang, Yazdan Maghsoud, Erik Antonio Vázquez-Montelongo, Zhifeng Jing, Rae M. Sammons, Eun Jeong Cho, Pengyu Ren, G. Andrés Cisneros, Jonathan M. Kurie, Kevin N. Dalby

Markey Cancer Center Faculty Publications

Lysyl hydroxylase 2 (LH2) catalyzes the formation of highly stable hydroxylysine aldehyde-derived collagen cross-links (HLCCs), thus promoting lung cancer metastasis through its capacity to modulate specific types of collagen cross-links within the tumor stroma. Using 1 and 2 from our previous high-throughput screening (HTS) as lead probes, we prepared a series of 1,3-diketone analogues, 1−18, and identified 12 and 13 that inhibit LH2 with IC50’s of approximately 300 and 500 nM, respectively. Compounds 12 and 13 demonstrate selectivity for LH2 over LH1 and LH3. Quantum mechanics/molecular mechanics (QM/MM) modeling indicates that the selectivity of 12 and 13 may stem from …

Donald Trump’S Contribution To The Study Of Politics And The Life Sciences, John Hibbing

Department of Political Science: Faculty Publications

If the life sciences are to have much to say about politics, there needs to be a universal element to political orientations. In this essay, I argue that the recent prominence of nativist, law-and-order, populist politicians reveals the nature of this universal element. All social units have to address bedrock dilemmas about how to deal with norm violators and how welcoming to be to outsiders as well as to proponents of new lifestyles. Might differences on these core dilemmas be the universal element of political life? Using the followers of one of the most prominent examples of a nativist political …

Molecular Pathology Of Colorectal Cancer: The Saudi Situation In Perspective, Abdulaziz Alfahed

Saudi Medical Journal

Colorectal cancer (CRC) is one of the most common cancers worldwide, and one of the most common causes of cancer deaths. In recent times, significant advancements have been made in elucidating the molecular alterations of the disease, and the results have been an improved understanding of CRC biology, as well as the discovery of biomarkers of diagnostic, prognostic, and therapeutic significance. In this review, an evaluation is carried out of the molecular pathology research of CRC emanating from Saudi Arabia. The verdict is that the data on the molecular alterations in CRC from Saudi patients is at best modest. This …

Comparison Of The Effects Of Alpha Lipoic Acid And Dexpanthenol In An Experimental Tracheal Reconstruction Animal Model, Murat Kuru, Tamer Altınok, Bayram Metin, Hacı Hasan Esen

Saudi Medical Journal

Objectives: To investigate the positive effects of intraperitoneal administration of alpha-lipolic acid (ALA) and dexpanthenol (DXP) on wound healing after tracheal surgery in rats. Methods: The study was carried out at Necmettin Erbakan University, Konya, Turkey, from January 2014-2019. A total of 30 healthy and adult Sprague-Dawley type female rats were included in the study. For the experiment, rats were randomly divided into 3 groups: ALA group (n=10), DXP group (n=10), and control group (n=10). After trachea surgery, 100 mg/kg/day ALA was given to group ALA and 100 mg/kg/day intraperitoneal DXP to group DXP for 15 days, and the rats …

Effect Of Platelet Indices On Postoperative Pain And Edema In Bimaxillary Surgery, Seher Orbay Yaşlı, Dilek Günay Canpolat, Fatma Doğruel, Selin Çelebi, Tekindal M. Agah, Demirbas A. Emin

Saudi Medical Journal

Objectives: To investigate the influence of platelet volume indices (PVI) on postoperative pain and edema in patients undergoing bimaxillary surgery and assessed the associations between PVI parameters and other clinical factors. Methods: We examined the medical records of 50 patients aged 18-40, treated between 2019 and 2020. Platelet indices (platelet count [PLT]), mean platelet volume, platelet distribution width, plateletcrit (PCT), and platelet large cell ratio) were analyzed. Postoperative pain and edema were assessed based on the frequency of intravenous (IV) analgesic administration and 3D imaging. A lasso-penalized regression was used for the analysis. Results: Significant positive correlations were observed between …

Robust Analysis Challenges Theory That Depression And Anxiety Increase Cancer Risk

Saudi Medical Journal

No abstract provided.

Antiviral Susceptibility Of Clade 2.3.4.4b Highly Pathogenic Avian Influenza A(H5n1) Viruses Isolated From Birds And Mammals In The United States, 2022, Ha T. Nguyen, Anton Chesnokov, Juan De La Cruz, Philippe Noriel Q. Pascua, Vasiliy P. Mishin, Yunho Jang, Joyce Jones, Han Di, Andrei A. Ivashchenko, Mary Lea Killian, Mia K. Torchetti, Kristina Lantz, David E. Wentworth, Charles T. Davis, Alexandre V. Ivachtchenko, Larisa V. Gubareva

United States Department of Agriculture Wildlife Services: Staff Publications

Clade 2.3.4.4b highly pathogenic avian influenza (HPAI) A(H5N1) viruses that are responsible for devastating outbreaks in birds and mammals pose a potential threat to public health. Here, we evaluated their susceptibility to influenza antivirals. Of 1,015 sequences of HPAI A(H5N1) viruses collected in the United States during 2022, eight viruses (∼0.8%) had a molecular marker of drug resistance to an FDA-approved antiviral: three adamantane-resistant (M2-V27A), four oseltamivir-resistant (NA-H275Y), and one baloxavir-resistant (PA-I38T). Additionally, 31 viruses contained mutations that may reduce susceptibility to inhibitors of neuraminidase (NA) (n = 20) or cap-dependent endonuclease (CEN) (n = 11). A panel of 22 …

Finding The Variables That React: Relationships Between Ability Beliefs And Student Achievement In An Inquiry-Based Introductory Chemistry Laboratory Course, Lindsay B. Wheeler, Amanda L. Gonczi

Michigan Tech Publications

This quantitative, exploratory study examined whether a Project-Based Guided Inquiry (PBGI) chemistry laboratory course supported more incremental ability beliefs among students, examined achievement outcomes for students grouped based on changes in student-reported chemistry ability beliefs from pre- to post-course, and provided explanations for differences in achievement and chemistry ability beliefs. Data sources included pre/post surveys of 367 undergraduate students' and 18 teaching assistants' (TAs) content knowledge, ability beliefs, sociodemographics (e.g., gender, race), and prior chemistry experience. The hierarchical linear regression (HLR) model accounted for 27.4% of the variance in post-content scores, with male students and students with more prior chemistry …

Microplastics Distribution Within Western Arctic Seawater And Sea Ice, Alessandra D’Angelo, Nicole Trenholm, Brice Loose, Laura Glastra, Jacob Strock, Jongsun Kim

Graduate School of Oceanography Faculty Publications

Microplastic pollution has emerged as a global environmental concern, exhibiting wide distribution within marine ecosystems, including the Arctic Ocean. Limited Arctic microplastic data exist from beached plastics, seabed sediments, floating plastics, and sea ice. However, no studies have examined microplastics in the sea ice of the Canadian Arctic Archipelago and Tallurutiup Imanga National Marine Conservation Area, and few have explored Arctic marginal seas’ water column. The majority of the microplastic data originates from the Eurasian Arctic, with limited data available from other regions of the Arctic Ocean. This study presents data from two distinct campaigns in the Canadian Arctic Archipelago …

Perioperative Opioids And Survival Outcomes In Resectable Head And Neck Cancer: A Systematic Review., Eric V Mastrolonardo, Derek S Mann, Harleen K. Sethi, Bo H Yun, Elliott M Sina, Maria Armache, Brooke Worster, Christopher E Fundakowski, Leila J Mady

Otolaryngology (ENT) Resident Research

BACKGROUND: Opioids are a mainstay in pain control for oncologic surgery. The objective of this systematic review is to evaluate the associations of perioperative opioid use with overall survival (OS) and disease-free survival (DFS) in patients with resectable head and neck cancer (HNC).

METHODS: A systematic review of PubMed, SCOPUS, and CINAHL between 2000 and 2022 was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies investigating perioperative opioid use for patients with HNC undergoing surgical resection and its association with OS and DFS were included.

RESULTS: Three thousand three hundred seventy-eight studies met initial inclusion …

What Is It Like To Be A Brain Organoid? Phenomenal Consciousness In A Biological Neural Network, Ivanna Montoya, Daniel Montoya

College of Humanities and Social Sciences

It has been shown that three-dimensional self-assembled multicellular structures derived from human pluripotent stem cells show electrical activity similar to EEG. More recently, neurons were successfully embedded in digital game worlds. The biologically inspired neural network (BNN), expressing human cortical cells, was able to show internal modification and learn the task at hand (predicting the trajectory of a digital ball while moving a digital paddle). In other words, the system allowed to read motor information and write sensory data into cell cultures. In this article, we discuss Neural Correlates of Consciousness (NCC) theories, and their capacity to predict or even …

An Alternative Method For Estimating The Phase Fraction Of Multiphase Nanomaterials: Analysis From X-Ray Diffraction, Peverga Jubu, Khaled Chahrour, Yushamdan Yusof, A. Nathan-Abutu, V. Igba, E. Danladi, O. Obaseki, M. Ochang, W. Zhiya, F. Yam

Journal of Applied Sciences and Nanotechnology

The presence of multiple phases/ components within a nanocomposite material impacts its properties. Therefore, there is a need to estimate the phase fraction of each element present in a sample. Spurr-Myers proposed a valuable formula for calculating the rutile and anatase phase fraction of a TiO2 sample from X-ray diffraction. However, this formula is dedicated to TiO2 and is inapplicable to samples that contain more than two phases. The present research proposed a simple method for quantifying the phase fraction of all types of nanomaterials consisting of two or more phases. The precision/ accuracy test, conducted by multiplying the total …

The Effect Of Nutrients And Their Role In The Progression Of Periodontal Disease, Sara Ali, M. Ali, Abdulnasser Al-Gebori, Hassanien Al-Jumaily, Poh Ooi, Asalnov Nuraddin

Journal of Applied Sciences and Nanotechnology

Periodontal disease is a common disease and may affect 90% of people and is classified into gingivitis and periodontitis. The objective of this study was if the deficiency of some vitamins and trace elements affects the increase in exposure to periodontal diseases or to find out whether the periodontal disease can cause changes in the blood level of some nutrients and their role in reducing periodontal diseases. For this purpose, samples were collected from the University of Baghdad, College of Dentistry, Department of Periodontics, Periodontics Clinic, including a group of 40 patients with periodontitis and another 40 patients with gingivitis …

Fors 333.01: Fire Ecology, Philp Higuera

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Csd 222.51: Introduction To Audiology, Catherine A. Drescher

University of Montana Course Syllabi, 2021-2025

No abstract provided.