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Differences In The Critical Thermal Maximum Between Two Size Classes Of Stenonema Femoratum (Ephemeroptera: Heptageniidae), Jaiden Frantz, David Houghton

The Great Lakes Entomologist

Temperature is an important variable affecting the behavior and survival of aquatic organisms; however, little is known about the effects of size and corresponding developmental differences on aquatic insect temperature tolerance. We tested the critical thermal maximum (CTM) of large (head capsule width mean = 3.5 mm) and small (1.9 mm) specimens of Stenonema femoratum (Say) by raising the experimental temperature by 0.1, 0.3, and 0.5ºC per minute during laboratory CTM trials. Size class and temperature increase rate combinations were randomized, and each combination was tested over four trials, for a total of 24 trials of four specimens each. Two-way …

The Caddisflies (Trichoptera) Of Finch Creek, Antrim County, Michigan (Usa), David Houghton, Robert Haack

The Great Lakes Entomologist

The caddisfly assemblages of Finch Creek, a small woodland stream in northern Lower Michigan, was sampled along its entire continuum during May, June, July, and September 2021–2022 using ultraviolet blacklight traps. A total of 98 species representing 15 families and 49 genera were collected, including two species [Lepidostoma prominens (Banks) and L. sommermanae (Ross)] not previously reported from Michigan, and several others either not previously found in the Lower Peninsula or not reported from the state for >70 years. A non-metric multidimensional scaling ordination determined distinct species assemblages corresponding to the spring, summer, and fall months. Shredders dominated the …

The Caddisflies (Trichoptera) Of Drummond Island, Michigan, With An Assessment Of Lake Assemblage Biomass, David Houghton, Robert Haack

The Great Lakes Entomologist

The adult caddisfly assemblages of Drummond Island, a Michigan island in Lake Huron near the Canadian border, were sampled in 2021–2022 from 3 sites on Lake Huron, 8 inland lakes, 2 vernal pools, and 1 stream. Adult caddisflies from each site were sampled in spring, summer, and autumn using ultraviolet blacklight traps. A total of 89 species representing 37 genera and 12 families was collected, including several not seen in Michigan for 50–70 years and the first confirmation of the rare species Beothukus complicatus (Banks) (Phryganeidae) from the state. A non-metric multidimensional scaling ordination determined distinct species assemblages between lakes, …

New Province Records Of Southern Ontario Caddisflies (Trichoptera), David Houghton, David Etnier

The Great Lakes Entomologist

Thirty-two caddisfly species are reported from Ontario for the first time, including 24 in the family Hydroptilidae, three in the Hydropsychidae, and one each in the Leptoceridae, Limnephilidae, Molannidae, and Polycentropodidae. The known caddisfly richness of the province increases from 309 to 341 species, including a doubling of the known hydroptilid fauna. Many more species undoubtedly remain to be discovered in this large and relatively undisturbed province.

Temporal Changes In Temperature May Suggest Microhabitat Shifts In Larval Spongillafly Climacia Areolaris Hagen (Neuroptera: Sisyridae) Abundance And Density In A Temperate Freshwater Lake, John R. Wallace, M. Eric Benbow, Cindy Willman-Kinsey

The Great Lakes Entomologist

Abiotic factors such as temperature and depth are known to affect aquatic insect populations and are thought to be major variables that directly impact how communities are assembled and populations distributed. The purpose of this study was to examine the role of temperature and depth in structuring C. areolaris populations within a temperate freshwater quarry. Larval densities among individual sponges at different depths were determined over six months in a Pennsylvania quarry. Sponges from four depths (7.0 - 8.0 m; 8.1 - 9.0 m; 9.1 - 10.0 m and 10.1 - 12.0) were collected once per month (n = 3) …

Characterizing Insect Communities Within Thin-Soil Environments, Katherine Mcnamara Manning, Kayla I. Perry, Christie A. Bahlai

The Great Lakes Entomologist

Natural thin-soil environments are those which have little to no soil accumulation atop hard substrates. Many of these natural thin-soil environments, such as alvars, rocky lakeshores or glades, cliffs and cliff bluffs, and barrens, are found in the Great Lakes Region of North America. Due to their ubiquity and ecosystem services they provide, characterizing insects in sensitive environments such as these is important. This study monitored insects in nine thin-soil sites, within three regions, on a 630 km latitudinal gradient in the Southeastern Great Lakes Region of North America from June - August 2019. Over 22,000 insect specimens collected were …

Cover Pages For Tgle Vol. 56 Nos. 1 & 2

The Great Lakes Entomologist

Cover Pages for TGLE Vol. 56 Nos. 1 & 2

Streamlined Synthesis Of Potential Dual-Emissive Fluorescent Silicon Quantum Dots (Siqds) For Cell Imaging, Di Sun, Steven Wu, Jeremy P. Martin, Kirati Tayutivutikul, Guodong Du, Colin Combs, Diane Darland, Julia Zhao

Biology Faculty Publications

One of the current challenges of working with nanomaterials in bioapplications is having a tool that is biocompatible (non-toxic) and produces stable, intense fluorescence for bioimaging. To address these challenges, we have developed a streamlined and one-pot synthetic route for silicon-based quantum dots (SiQDs) using a hydrothermal method. Part of our unique approach for designing the SiQDs was to incorporate (3-aminopropyl) triethoxysilane (APTES), which is an amphipathic molecule with hydroxyl and amine functional groups available for modification. In order to reduce the toxicity of APTES, we chose glucose as a reducing agent for the reaction. The resulting SiQDs produced potent, …

Think Again: The Role Of Reappraisal In Reducing Negative Valence Bias, Maital Neta, Nicholas R. Harp, Tien T. Tong, Claudia J. Clinchard, Catherine C. Brown, James J. Gross, Andero Uusberg

Department of Psychology: Faculty Publications

Stimuli such as surprised faces are ambiguous in that they are associated with both positive and negative outcomes. Interestingly, people differ reliably in whether they evaluate these and other ambiguous stimuli as positive or negative, and we have argued that a positive evaluation relies in part on a biasing of the appraisal processes via reappraisal. To further test this idea, we conducted two studies to evaluate whether increasing the cognitive accessibility of reappraisal through a brief emotion regulation task would lead to an increase in positive evaluations of ambiguity. Supporting this prediction, we demonstrated that cuing reappraisal, but not in …

Objectivity, Practicality, And Significance Of Practice Guidelines For The Practicing Neurologists: What We Learnt From Consensus Criteria In Cidp, Myasthenia Gravis And Inflammatory Myopathies, Marinos C. Dalakas

Department of Neurology Faculty Papers

The value of practice guidelines in the three most common autoimmune neuromuscular disorders, namely Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), Myasthenia Gravis (MG) and Autoimmune Inflammatory Myopathies (AIM), has been extensively debated regarding their usefulness in clinical practice, objectivity and universal value considering that guidelines are also established regionally in certain countries. This commentary highlights common concerns on how guidelines are presently generated, pointing out: (a) non-sufficient diversity among Task-Force members to identify and address not only routine clinical and electrophysiology issues but also immunology, imaging, pathology, biomarkers, epidemiology or treatment economics; (b) Task-Force being often comprised by the same or …

Low-Grade Serous Ovarian Cancer: Expert Consensus Report On The State Of The Science, Rachel N Grisham, Brian M Slomovitz, Nicole Andrews, Susana Banerjee, Jubilee Brown, Mark S Carey, Herman Chui, Robert L Coleman, Amanda N Fader, Stephanie Gaillard, Charlie Gourley, Anil K Sood, Bradley J Monk, Kathleen N Moore, Isabelle Ray-Coquard, Ie-Ming Shih, Shannon N Westin, Kwong-Kwok Wong, David M Gershenson

Faculty, Staff and Student Publications

Compared with high-grade serous carcinoma, low-grade serous carcinoma of the ovary or peritoneum is a less frequent epithelial ovarian cancer type that is poorly sensitive to chemotherapy and affects younger women, many of whom endure years of ineffective treatments and poor quality of life. The pathogenesis of this disease and its management remain incompletely understood. However, recent advances in the molecular characterization of the disease and identification of novel targeted therapies with activity in low-grade serous carcinoma offer the promise of improved outcomes. To update clinicians regarding recent scientific and clinical trial advancements and discuss unanswered questions related to low-grade …

Intouch Week Of September 4, 2023, New York Medical College

InTouch

• Dr. Sangmi Chung Awarded $7.1 Million in Grants to Support Schizophrenia Research
• Non-Invasive Test Can Detect Oral and Throat Cancer at Early Stages
• Chess Comes Alive on NYMC Campus
• D.P.T. Students Offer Fitness and Wellness Consultations for Children, Adults and Seniors
• NYMC Club Fair 2023: A Vibrant Showcase of Student Engagement and Diversity
• Bench Donated By Dr. Jerry Nadler Adorns Maryann’s Garden
• Office of Public Safety Stresses Campus Parking Regulations
• SHSP Café is open
• NYMC and TU Hosts “Ninety Minutes: The Medical Magazine of the Web”
• The NYMC Community Comes Together For the First Blood Drive of the Academic Year

Enhancement Of Propagation Using Organic Materials And Growth Hormone: A Study On The Effectiveness Of Growth And Rooting Of Pomegranate Cuttings, Shafiqullah Aryan, Gulbuddin Gulab, Zabihullah Safi, Asmatullah Durani, Mohammad Ghani Raghib, Kifayatullah Kakar, Tayebullah Zahid, Bakht Munir Baber, Yogesh Ahlawat, Ihab Mohamed Moussa, Hosam O. Elansary

Michigan Tech Publications

Pomegranate production in Afghanistan is increasing remarkably, but nursery services are lacking, leading to inconsistent growth and low rooting percentages in cuttings. Hence, this research was conducted at the greenhouse of Nangarhar University, Faculty of Agriculture, to investigate the efficacy of indole-3-butyric acid (IBA) and organic materials, namely banana, garlic, aloe vera, and panchagavya, as rooting promoters on cuttings of the ideal seedless pomegranate cultivar (Bedana). The cuttings were derived from one-year-old dormant branches in mid-February of 2023. The findings indicated that panchagavya and aloe vera significantly (p < 0.05) accelerated the sprouting process of pomegranate cuttings, resulting in 100% rooting, while IBA showed a delayed initiation of sprouting. In contrast, banana had a detrimental effect on the sprouting of the cuttings. IBA and organic materials, except banana and garlic, significantly influenced all the shoot parameters. Among the treatments, panchagavya (21.1%), IBA (23.4%), and aloe vera (26.8%) demonstrated the highest number of shoots per cutting compared to the control. A consistent soil plant analysis development (SPAD) pattern was observed across treatments, positively correlating with shoot and root parameters (range, r = 0.30–0.97). The application of organic materials significantly (p < 0.05) impacted root length, acrobasal roots, root diameter, total root length, and root fresh weight. However, banana and garlic yielded contrasting results in most of these parameters. In conclusion, aloe vera and panchagavya are found to be more suitable for propagating pomegranates through cuttings, making them excellent alternatives to IBA for nurserymen and companies.

Mitochondrial Pyruvate Metabolism And Glutaminolysis Toggle Steady-State And Emergency Myelopoiesis, Hannah A Pizzato, Yahui Wang, Michael J Wolfgang, Brian N Finck, Gary J Patti, Deepta Bhattacharya

2020-Current year OA Pubs

To define the metabolic requirements of hematopoiesis, we examined blood lineages in mice conditionally deficient in genes required for long-chain fatty acid oxidation (Cpt2), glutaminolysis (Gls), or mitochondrial pyruvate import (Mpc2). Genetic ablation of Cpt2 or Gls minimally impacted most blood lineages. In contrast, deletion of Mpc2 led to a sharp decline in mature myeloid cells and a slower reduction in T cells, whereas other hematopoietic lineages were unaffected. Yet MPC2-deficient monocytes and neutrophils rapidly recovered due to a transient and specific increase in myeloid progenitor proliferation. Competitive bone marrow chimera and stable isotope tracing experiments demonstrated that this proliferative …

Surgical Management Of Congenital Malrotation Presenting In Adulthood., Jacob Holzemer, Krishna Patel, Oscar Ruiz, Jodi Oostra

Surgery Articles

Intestinal malrotation is characterised by positional and congenital fixation abnormalities resulting from a failure in embryonic development in the normal 270° rotation around the axis of the superior mesenteric artery. Intestinal malrotation is primarily thought to affect neonates with an incidence of 1 in 500, however, only 1 in 6000 live births are symptomatic, and these usually present within the first month of life in 40% of cases and within the first year in over 5% of cases as an obstructive pathology or volvulus. In adults, however, the incidence has been documented at 0.2%. These patients usually present with postprandial …

Kv12-Encoded K+ Channels Drive The Day-Night Switch In The Repetitive Firing Rates Of Scn Neurons, Tracey O Hermanstyne, Nien-Du Yang, Daniel Granados-Fuentes, Xiaofan Li, Rebecca L Mellor, Timothy Jegla, Erik D Herzog, Jeanne M Nerbonne

2020-Current year OA Pubs

Considerable evidence suggests that day-night rhythms in the functional expression of subthreshold potassium (K+) channels regulate daily oscillations in the spontaneous firing rates of neurons in the suprachiasmatic nucleus (SCN), the master circadian pacemaker in mammals. The K+ conductance(s) driving these daily rhythms in the repetitive firing rates of SCN neurons, however, have not been identified. To test the hypothesis that subthreshold Kv12.1/Kv12.2-encoded K+ channels play a role, we obtained current-clamp recordings from SCN neurons in slices prepared from adult mice harboring targeted disruptions in the Kcnh8 (Kv12.1-/-) or Kcnh3 (Kv12.2-/-) locus. We found that mean nighttime repetitive firing rates …

Determinants Of Ifgf13-Mediated Regulation Of Myocardial Voltage-Gated Sodium (Nav) Channels In Mouse, Adrien Lesage, Maxime Lorenzini, Sophie Burel, Marine Sarlandie, Floriane Bibault, Cecilia Lindskog, Daniel Maloney, Jonathan R Silva, R Reid Townsend, Jeanne M Nerbonne, Céline Marionneau

2020-Current year OA Pubs

Posttranslational regulation of cardiac NaV1.5 channels is critical in modulating channel expression and function, yet their regulation by phosphorylation of accessory proteins has gone largely unexplored. Using phosphoproteomic analysis of NaV channel complexes from adult mouse left ventricles, we identified nine phosphorylation sites on intracellular fibroblast growth factor 13 (iFGF13). To explore the potential roles of these phosphosites in regulating cardiac NaV currents, we abolished expression of iFGF13 in neonatal and adult mouse ventricular myocytes and rescued it with wild-type (WT), phosphosilent, or phosphomimetic iFGF13-VY. While the increased rate of closed-state inactivation of NaV channels induced by Fgf13 knockout in …

The Impact Of Covid-19 On Carotid-Femoral Pulse Wave Velocity: A Systematic Review And Meta-Analysis, Iwona Jannasz, Michal Pruc, Mansur Rahnama-Hezavah, Tomasz Targowski, Robert Olszewski, Stepan Feduniw, Karolina Petryka, Lukasz Szarpak

Faculty, Staff and Students Publications

COVID-19 is a complex multisystemic disease that can result in long-term complications and, in severe cases, death. This study investigated the effect of COVID-19 on carotid–femoral pulse wave velocity (cfPWV) as a measurement to evaluate its impact on arterial stiffness and might help predict COVID-19-related cardiovascular (CV) complications. PubMed, Web of Science, Embase, and the Cochrane Library were searched for relevant studies, and meta-analysis was performed. The study protocol was registered in PROSPERO (nr. CRD42023434326). The Newcastle–Ottawa Quality Scale was used to evaluate the quality of the included studies. Nine studies reported cfPWV among COVID-19 patients and control groups. The …

Evaluation Of In Vitro Antioxidant, Anti-Obesity, And Anti-Diabetic Activities Of, Alaa S Mohamed, Essam Mohamed Elsebaie, Wesam Mohammed Abdelrhman, Nabila Yahia Mahmoud Abdulmaguid, Rasha M Bahnasy, Manal Salah Abbas Elgendy, Arwa Mohamed Mohamed Mahmoud Elashry, Marwa Fawzy El-Hassanin, Nora Hamdy Mouhamed El-Wakeil, Azhar Mostafa Mohamed Khalil, Hesham F Amin

Faculty, Staff and Student Publications

Opuntia ficus cladodes (OFC) are considered one of the wastes that result from opuntia cultivation, and their disposal by traditional methods results in many environmental problems. Therefore, this study was conducted with two aims. The first was the production of OFC gel, and the evaluation of its in vitro antioxidant (by two methods, DPPH and ABTS), anti-obesity, and anti-diabetic activities. The second was an investigation of the effects of different concentrations of this gel (0, 50, and 100%) as an edible coating on the quality of shrimp during 8 days of refrigerated storage. The results showed that this gel was …

The Characterization And Evaluation Of The Soluble Triggering Receptor Expressed On Myeloid Cells-Like Transcript-1 In Stable Coronary Artery Disease, Zaida Bayrón-Marrero, Siobhan Branfield, Javier Menéndez-Pérez, Benjamín Nieves-López, Laura Ospina, Yadira Cantres-Rosario, Loyda M Melendez, Robert Hunter, Angelia Gibson, Gerónimo Maldonado-Martínez, A Valance Washington

Faculty, Staff and Student Publications

Platelets play crucial roles in the development and progression of coronary artery disease (CAD). The triggering receptor expressed in myeloid cells-like transcript-1 (TLT-1) is stored in platelet α granules, and activated platelets release a soluble fragment (sTLT-1). We set out to better characterize the constituent amino acids of sTLT-1 and to evaluate sTLT-1 for use as a biomarker in patients with stable CAD. We evaluated sTLT-1 release using immunoprecipitation and mass spectrometry and employed statistical methods to retrospectively correlate sTLT-1 concentrations, utilizing ELISA in plasma samples from 1510 patients with documented stable CAD. We identified TLT-1 residues to 133 in …

In Vitro Antioxidant, Anti-Inflammatory, And Photoprotective Activities Of Aqueous Extract Of The Endemic Plant Hammada Scoparia L. From Algeria, Benine Chaima, Djahra Ali Boutlelis, Laiche Ammar Touhami, Tlili Hajer, Tliba Ali, Ben Arfa Abdelkarim, Najjaa Hanen

Karbala International Journal of Modern Science

This study aimed to analyze the chemical profile and evaluate the biological activities of the aqueous extract of H. Scoparia, an endemic plant found in Southeastern Algeria. The aqueous extract was subjected to phytochemical screening, RP-HPLC, and FT-IR analysis. The anti-inflammatory activity was examined using the protein denaturation method, and the photoprotective activity was evaluated using UV-Visible spectrophotometry. The antioxidant activity was assessed using ABTS, DPPH, and FRAP assays. The study found the presence of various secondary metabolites such as polyphenols, tannins, and saponins. This study suggests that H. Scoparia extract has the potential as a natural source of bio-actives …

Themes, Resources And Uptake Of Acer’S Science In The Early Years Suite, Gayl O'Connor

2021-2030 ACER Research Conferences

The Science in the early years series was developed to assist preschool and Foundation to year 2 primary educators to incorporate the latest research in science learning into their programs and teaching practice. This paper focuses on the educator resources developed to support early years educators implement activities to assist children to develop science concepts and inquiry skills. The activities are underpinned by evidence-based research that revealed 4 themes in the early years’ science literature.

Research Conference 2023: Becoming Lifelong Learners. Proceedings And Program, Kylie Burns (Ed.)

2021-2030 ACER Research Conferences

We know learning in the early years sets the foundations for people’s ongoing academic, cognitive and socio-emotional development. Education across those formative first 12 years is currently segmented, with children often starting fresh in new systems. How can each of us make learning in the early childhood and primary years more effective? Research Conference 2023 will examine research around how we can improve the continuity of learning from birth to 12 years. It will bring together leading international and Australian researchers to provide insights into the best ways to identify, conceptualise, develop and assess these new linkages for learning.

Are Scientific Memes Motivating And Does Public Sharing Affect Motivation?, Virginia Clinton-Lisell, Alison E. Kelly

Education, Health & Behavior Studies Faculty Publications

In recent years, renewable assignments, or student creations that have value outside of a course, have received considerable attention. However, there is little theoretically grounded inquiry into students’ motivation for renewable assignments such as scientific memes. Moreover, it is unknown how public sharing of renewable assignments affects students’ perceived value and learning from coursework. In addition, public sharing could logically affect students’ pride and anxiety related to the renewable assignment, but this lacks empirical testing. The purpose of this study was to determine the effects of public sharing of renewable assignments on students’ perceived value, learning, pride, and anxiety relevant …

Model Binding Experiments With Cucurbit[7]Uril And P-Sulfonatocalix[4]Arene Support Use Of Explicit Solvation Term In Governing Equation For Binding Equilibria, Daryl Eggers, Adam Brewer, Kimberly J. Cacatian, L. Allison Camat, Dominic Castagnoli, Nina Chuang, Lillian N. Chung, Thanh Do, Emily Huynh, Thanayuth Jenpichitkulchai, Anoop Kaur, Frank Le, Roy Ong, Duc Pham, Kevin Shao

Faculty Research, Scholarly, and Creative Activity

The thermodynamics of model host–guest-binding reactions is examined in depth using isothermal titration calorimetry. In conflict with classical thermodynamics, the results indicate that the equilibrium-binding quotient, K, is not a constant for all pairings. This outcome is predicted by an equation for binding equilibria that includes an explicit term for the change in solvation free energy that accompanies the formation of a binary complex. Application of this framework to the experimentally observed concentration dependence of K allows one to obtain the energetic contribution of the solvent, a linked equilibrium denoted here as ΔGH2O. The estimated values of ΔGH2O are large …

Lessons From An Md Phd – From Slc13a5 To Neurology, Jonathan Kopel, Jeffrey Clothier

Journal of Community Hospital Internal Medicine Perspectives

The journey towards becoming a physician scientist is a long, arduous, and uncertain journey. Few medical students pursue a career as a physician scientist. Even those that do, the path towards maintaining a robust research career and clinical training can be difficult given the personal and social pressures to focus solely on research or clinical work. Despite the long history of science and medicine, there is question concerning the role that physician scientist in modern medicine. As a recent physician scientist graduate, I feel that physician scientists are greatly needed in the medical profession. The ability to overlap science, medicine, …

Enhanced Performance Of On-Chip Integrated Biosensor Using Deep Learning, Thomas J. Mikhail, Raghi El Shamy, Mohamed A. Swillam, Xun Li

Faculty Journal Articles

No abstract provided.

Mesenchymal-Derived Extracellular Vesicles Enhance Microglia-Mediated Synapse Remodeling After Cortical Injury In Aging Rhesus Monkeys, Yuxin Zhou, Hrishti Bhatt, Chromewell A. Mojica, Hongqi Xin, Monica A. Pessina, Douglas L. Rosene, Tara L. Moore, Maria Medalla

Neurology Articles

Understanding the microglial neuro-immune interactions in the primate brain is vital to developing therapeutics for cortical injury, such as stroke or traumatic brain injury. Our previous work showed that mesenchymal-derived extracellular vesicles (MSC-EVs) enhanced motor recovery in aged rhesus monkeys following injury of primary motor cortex (M1), by promoting homeostatic ramified microglia, reducing injury-related neuronal hyperexcitability, and enhancing synaptic plasticity in perilesional cortices. A focal lesion was induced via surgical ablation of pial blood vessels over lying the cortical hand representation of M1 of aged female rhesus monkeys, that received intravenous infusions of either vehicle (veh) or EVs 24 h …

Identifying Early-Life Behavior To Predict Mothering Ability In Swine Utilizing NuTrack System, Savannah Millburn, Ty B. Schmidt, Gary A. Rohrer, Benny Mote

Department of Animal Science: Faculty Publications

Early indicator traits for swine reproduction and longevity support economical selection decision-making. Activity is a key variable impacting a sow’s herd life and productivity. Early-life activities could contribute to farrowing traits including gestation length (GL), number born alive (NBA), and number weaned (NW). Beginning at 20 weeks of age, 480 gilts were video recorded for 7 consecutive days and processed using the NUtrack system. Activity traits included angle rotated (radians), average speed (m/s), distance traveled (m), time spent eating (s), lying lateral (s), lying sternal (s), standing (s), and sitting (s). Final daily activity values were averaged across the …

Integrating Glycolysis, Citric Acid Cycle, Pentose Phosphate Pathway, And Fatty Acid Beta‑Oxidation Into A Single Computational Model, Sylwester M. Kloska, Krzysztof Pałczyński, Tomasz Marciniak, Tomasz Talaśka, Beata J. Wysocki, Paul H. Davis, Tadeusz A. Wysocki

Department of Electrical and Computer Engineering: Faculty Publications

The metabolic network of a living cell is highly intricate and involves complex interactions between various pathways. In this study, we propose a computational model that integrates glycolysis, the pentose phosphate pathway (PPP), the fatty acids beta-oxidation, and the tricarboxylic acid cycle (TCA cycle) using queueing theory. The model utilizes literature data on metabolite concentrations and enzyme kinetic constants to calculate the probabilities of individual reactions occurring on a microscopic scale, which can be viewed as the reaction rates on a macroscopic scale. However, it should be noted that the model has some limitations, including not accounting for all the …