Digital Commons Network^™

Jefferson Breast Surgeon Selected For Second Cohort Of Robert A. Winn Career Development Award

Jefferson Surgical Solutions

The Bristol Myers Squibb Foundation established the Robert A. Winn Career Development Award (CDA) to increase diversity in clinical trials and transform the clinical research landscape. The program aims to improve representation among two key populations: patients participating in trials as well as the clinicians and scientists leading clinical trials. Assistant Professor of Surgery Adeseye Adekeye, MD, PhD, is one of 64 early-stage investigators selected for the second cohort of the Winn CDA program. The program funds $120,000 a year for two years, with the awardees spending at least 40% of their time on the program. Dr. Adekeye and the …

Illinois Masonic Hospital Association School Of Nursing Handbook, 1938, Advocate Aurora Health

Historical Documents - Combined

The Illinois Masonic Hospital Association School of Nursing, Chicago, IL: Handbook for incoming students at the nursing school. Contains course descriptions, faculty and staff directory, and student guidelines from the 1930s.

An Assessment Of Fetal Rhd Screening In Non-Invasive Prenatal Testing (Nipt) And Implementation Of Targeted Routine Antenatal Anti-D Prophylaxis (Traadp) In Enhancing Management Of Rhd-Negative Women At Risk Of Haemolytic Disease Of The Fetus/Newborn (Hdfn) In University Hospital Limerick Group (Uhlg), Anna Pohrebyannyk

International Undergraduate Journal of Health Sciences

Alloimmunisation, formerly isoimmunisation, or sensitisation can occur in pregnancy when a Rhesus D (RhD)-negative woman carries an RhD-positive fetus. Incompatibility of Rh status causes development of allo anti-D antibodies in response to antigen exposure from foreign fetal red cells in fetomaternal haemorrhages (FMHs) or potential sensitising events (PSEs) i.e., iatrogenic interventions (medical or surgical treatment), silent or spontaneous transplacental haemorrhages (STHs) in pregnancy, at birth or other traumas. Anti-D antibodies are immune-mediated and can cross the placenta and attach to fetal cells causing destruction and haemolysis. Offspring of primigravida women are unaffected usually and it is later pregnancies that may …

Chimeric Antigen Receptor (Car)-T Cell Therapy In The Treatment Of Haematological Malignancies, Karla O'Shea

International Undergraduate Journal of Health Sciences

The use of chimeric antigen receptor T (CAR-T) cells in the treatment of haematological malignancies, particularly relapsed/refractory (R/R) B cell malignancies, has resulted in quite a high success rate. The most popular CAR-T cell therapy targets currently are CD19 and B-cell maturation antigen (BCMA), though many other innovative therapeutic targets are being investigated. According to the National Cancer Institute BCMA is defined as an antigen found on the surfaces of B cells and is overexpressed on malignant plasma cells. Additionally, CD19 controls B cells in an antigen receptor-dependent way and is produced throughout the B cell differentiation process, particularly during …

The Use Of Prognostic Markers To Predict Disease Progression And Clinical Outcome In Monoclonal Gammopathy Of Undetermined Significance, Smouldering Multiple Myeloma And Multiple Myeloma., Róisín C. Mcmonagle

International Undergraduate Journal of Health Sciences

Multiple Myeloma (MM) is an incurable plasma cell malignancy with a complex and incompletely understood molecular pathogenesis. Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smouldering Multiple Myeloma (SMM) precede MM, with variable risks and rates of disease progression. The continuing high relapse and death rate in MM cases has prompted research into more accurate prognostic markers to predict progression from MGUS and SMM to MM, as well as identify MM cases with aggressive disease, in order to begin early, targeted and effective therapeutic intervention. Many studies have focused on utilising current markers more effectively, including M-protein, serum-free light chain ratio, …

An Investigation Into The Effect Of Screen Time On Sleep Quality Amongst Third Level Students, Emma Kelly, Sarah Williams, Cliona Sutton

International Undergraduate Journal of Health Sciences

This paper aimed to research the effect of screen time on sleep quality based on the opinions of 356 third-level students from various Irish Universities. This study considers factors such as sleep duration, the effect of the COVID-19 pandemic concerning online college and its effect on sleep quality and screen time duration. This study was conducted using an anonymous Google Forms survey consisting of 10 questions and gained ethical approval before distribution.

Most participants (56.1%) slept between 7-9 hours, which is within the recommended guidelines of sleep duration by the Health Service Executive (HSE, 2022). When asked about the effect …

The Role Of Digital Pathology For Histological Diagnosis, Ellen Faherty

International Undergraduate Journal of Health Sciences

Digital pathology is on its way to becoming a widespread alternative for routine diagnostics. Rapid whole slide image scanning has accelerated this advancement, but large-scale implementation is complex on technical, logistical, and financial levels. Although validation studies have published encouraging data on safety and feasibility, implementation experiences highlight the importance of training and knowledge of possible consequences. International pathology organisations' guidelines are intended to safeguard digital pathology, from image capture to long-term image archiving, but they should only be viewed as a starting point. Cost-efficiency reviews and occupational health issues must be thoroughly addressed. Image analysis is incorporated into traditional …

The Role Of Molecular Thyroseq V3 Testing For Diagnosis And Management Of Indeterminate Thyroid Nodules., Ruth Delahunty

International Undergraduate Journal of Health Sciences

Worldwide, thyroid cancer is the 8^th most common malignancy (3^rd most common in women) and in recent years, there has been increased incidence of thyroid cancer worldwide. There is currently said to be a of thyroid nodules as of 2022. When it comes to the management of indeterminate thyroid nodules, clinical decision making can be challenging.

Thyroseq V3 testing may be used to determine the percentage probability of a thyroid nodule of being either malignant or benign, through a complex algorithm with next generation sequencing techniques, currently testing is done in the University of Pittsburgh and therefore is …

The Prevalence Of And Attitudes Towards Blood Donation Among Third Level Students In Cork, Ireland, Ava Coakley, Sarah Ferguson, Nicole Ardenaso

International Undergraduate Journal of Health Sciences

In Ireland, one in four people will require a blood transfusion at some point in their life, yet only 3% of the eligible population donate blood. This study aimed to investigate the prevalence of and attitudes towards blood donation among third level students in Cork, Ireland. The demographic of students most likely to donate blood and incentives to encourage blood donation were identified. Peer-reviewed research papers were used to aid in survey design, created using Google Forms. The survey was distributed to registered University College Cork (UCC) and Munster Technological University (MTU) students. Ethical approval and the informed consent of …

Effect Of Caffeine In Pattern Memory And Reaction Time Test Among College Students, William T. Clark, Micheal Lawson, Garrett Garnto, Evan Smith, Kelly Massey

International Undergraduate Journal of Health Sciences

Caffeine is commonly used by college students to aid in staying alert throughout the day. The purpose of this study was to determine the effects of caffeine on visual memory and reaction time performance on college students aged 18-25 years old. The Human Benchmark (https://humanbenchmark.com) Visual Memory (VM) and Reaction Time (RT) tests were used to assess participant’s baseline scores and scores 15min post treatment. Five male (19.0y ± 1.26) and four female (20.3y ± 0.43) college students volunteered to be participants in a three-week long cross-over, counterbalanced study. Blood pressure (BP) and heart rate (HR) were assessed before each …

Full Issue: The International Undergraduate Journal Of Health Sciences, Volume 3, Issue 1, September 2023, Sword Mtu

International Undergraduate Journal of Health Sciences

Full Issue: The International Undergraduate Journal of Health Sciences, Volume 3, Issue 1, September 2023

Icc Agenda 9-12-23, Angela Brock

Individual Course Committee (ICC)

No abstract provided.

Defining The Causes Of Sporadic Parkinson’S Disease In The Global Parkinson’S Genetics Program (Gp2), Clodagh Towns, Madeleine Richer, Simona Jasaityte, Eleanor J. Stafford

Faculty Journal Articles

No abstract provided.

Spartan Daily, September 12, 2023, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2023

Volume 161, Issue 09

Isscr Standards For The Use Of Human Stem Cells In Basic Research., Tenneille E Ludwig, Peter W Andrews, Ivana Barbaric, Nissim Benvenisty, Anita Bhattacharyya, Jeremy M Crook, Laurence M Daheron, Jonathan S Draper, Lyn E Healy, Meritxell Huch, Maneesha S Inamdar, Kim B Jensen, Andreas Kurtz, Madeline A Lancaster, Prisca Liberali, Matthias P Lutolf, Christine L Mummery, Martin Pera, Yoji Sato, Noriko Shimasaki, Austin G Smith, Jihwan Song, Claudia Spits, Glyn Stacey, Christine A Wells, Tongbiao Zhao, Jack T Mosher

Faculty Research 2023

The laboratory culture of human stem cells seeks to capture a cellular state as an in vitro surrogate of a biological system. For the results and outputs from this research to be accurate, meaningful, and durable, standards that ensure reproducibility and reliability of the data should be applied. Although such standards have been previously proposed for repositories and distribution centers, no widely accepted best practices exist for laboratory research with human pluripotent and tissue stem cells. To fill that void, the International Society for Stem Cell Research has developed a set of recommendations, including reporting criteria, for scientists in basic …

The Indiana Statesman, September 12, 2023, Indiana State University

Student Newspaper

9/11 nightmare never ends for cancer victims; FBI withholds records from Sept. 11; El Dorado pushes parental notification policy

Probing The Activation Mechanisms Of Agonist Dpi-287 To Delta-Opioid Receptor And Novel Agonists Using Ensemble-Based Virtual Screening With Molecular Dynamics Simulations., Emily Dean, Annemarie Dominique, Americus Palillero, Annie Tran, Nicholas Paradis, Chun Wu

College of Science & Mathematics Departmental Research

Pain drugs targeting mu-opioid receptors face major addiction problems that have caused an epidemic. The delta-opioid receptor (DOR) has shown to not cause addictive effects when bound to an agonist. While the active conformation of the DOR in complex with agonist DPI-287 has been recently solved, there are still no FDA-approved agonists targeting it, providing the opportunity for structure-based virtual screening. In this study, the conformational plasticity of the DOR was probed using molecular dynamics (MD) simulations, identifying two representative conformations from clustering analysis. The two MD conformations as well as the crystal conformation of DOR were used to screen …

Assessing Non-Invasive Imaging Devices To Detect Temperature Differentiation And Lymphatic/Venous Flow To The Head And Neck During Head Down Tilt, Supine, And Sitting Positions The Niid Study (Non-Invasive Imaging Device), Matthew Melin, Heather Hettrick, Frank Aviles, Johanna Pannunzio, Nathan Sirkis, Chantel Hubbard, Patrick Hardigan, Sabrina Ginsburg, Harvey N. Mayrovitz

HPD Articles

Under the influence of standard developmental physiology on the Earth’s surface (1 gravity equivalent known as “1G”), 70% of body fluids reside below the level of the heart.Fluid shifts towards the cephalic region during microgravity have also been speculated to contribute towards spaceflight associated neuroocular syndrome (SANS).Although a significant barrier to spaceflight, the underlying mechanism of SANS is not well understood, partially due to the spaceflight environment and limited medical capabilities including invasive diagnostic testing. Thus, non-invasive approaches to studying real-time fluid shifts in weightlessness could serve as critical areas of research to further SANS study and effective countermeasure protocol …

College Of Liberal Arts Faculty Bylaws - Amended 09/12/23, College Of Liberal Arts Faculty, Rollins College

College of Liberal Arts Bylaws

No abstract provided.

The Role Of Leading-Edge Serrations In Controlling The Flow Over Owls’ Wing, Tanner Saussaman, Asif Nafi, David Charland, Hadar Ben-Gida, Roi Gurka

Physics and Engineering Science

We studied the effects of leading-edge serrations on the flow dynamics developed over an owl wing model. Owls are predatory birds. Most owl species are nocturnal, with some active during the day. The nocturnal ones feature stealth capabilities that are partially attributed to their wing microfeatures. One of these microfeatures is small rigid combs (i.e. serrations) aligned at an angle with respect to the incoming flow located at the wings' leading-edge region of the primaries. These serrations are essentially passive flow control devices that enhance some of the owls' flight characteristics, such as aeroacoustics and, potentially, aerodynamics. We performed a …

Alzheimer's: An M.D./Ph.D. Graduate Student's Request For Yuhua Song As Mentor Leads To Two Nih R01 Awards Totaling $5 Million, Staff

Browse All News

No abstract provided.

Combining Simulations And Single Molecule Spectroscopy To Understand Sars-Cov-2 Nucleocapsid Protein-Rna Interactions, Jhullian Jamille Alston

Arts & Sciences Graduate Student Theses and Dissertations

Disordered protein regions play crucial roles in various cellular functions, exhibiting high heterogeneity and sampling an ensemble of conformations distinct from folded domains. However, our understanding of their behavior and contributions to protein-protein and protein-nucleic acid interactions remains limited. This dissertation focuses on investigating the interactions between disordered regions and RNA, as well as folded regions of proteins, utilizing computational modeling and single-molecule fluorescence spectroscopy. The SARS-CoV-2 Nucleocapsid (N) protein serves as a model system to address broader questions concerning disordered protein behavior and N protein-mediated RNA genome packaging. I employed coarse-grained molecular dynamic simulations to characterize the cooperative binding …

The Historical Ecology Of Late Archaic Mound Building In The Lower Mississippi Valley, Grace M. V. Ward

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation is a social and ecological analysis of the history of Native American mound-building from approximately 4000 to 3000 years ago in the Lower Mississippi Valley of the southeastern United States. It is comprised of three interlinked analyses. In the first, variation in material culture, architecture, and foodways is presented to suggest that the archaeological record of the Late Archaic Lower Mississippi Valley does not reflect a uniform regional culture. Rather, relationships between the two largest sites in the region –Jaketown and Poverty Point– indicate a heterarchical history in which communities selectively participated in larger social phenomena—such as exchange …

Role Of Copyback Viral Genomes In Activating Cellular Stress Responses During Pneumovirus And Paramyxovirus Infection, Lavinia Jose Gonzalez Aparicio

Arts & Sciences Graduate Student Theses and Dissertations

The interactions that occur between a virus and the infected cell determine the success of an infection. During negative-sense single-stranded RNA virus infections, copyback viral genomes (cbVGs) drive key virus-host interactions by activating the Mitochondrial Antiviral Signaling (MAVS) pathway that induces antiviral immunity and leads to reduced levels of virus replication. Whether cbVGs induce other cellular pathways and how these relate to their immunostimulatory activity is unknown. Here we show that cbVGs also induce a cellular stress response during pneumovirus and paramyxovirus infections. cbVGs activate the cellular stress response through Protein Kinase R (PKR) signaling, triggering translation inhibition and stress …

Method Of Delivering Genes And Drugs To A Posterior Segment Of An Eye, Shyam S. Mohapatra, Subhra Mohapatra, Eleni Markoutsa

USF Patents

A multifunctional dendrimer nanoparticle and method of treating diseases of the posterior segment of the eye is presented. The functionalized polyamidoamine (PAMAM) dendrimer effectively delivers drugs and/or genes to the posterior eye, thereby providing for the effective, non-invasive, and topical treatment of diseased in the posterior eye. The multifunctional dendrimer nanoparticle has shRNA-encoding DNA and small molecule drug encapsulated cyclodextrin complexed to the outer surface of the dendrimer for delivery to the posterior segment of the eye.

Investigating The Role Of Dcia During The Cell Cycle In Mycobacterium, Helen Catherine Blaine

Arts & Sciences Graduate Student Theses and Dissertations

The mycobacterial family contains many human pathogens, including Mycobacterium tuberculosis, Mycobacterium abcessus, and Mycobacterium leprae. Mycobacterium tuberculosis, the causative agent of the disease tuberculosis (TB), is a major public health problem. The emergence of increasing numbers of antibiotic resistant cases of TB has led to a push for novel drug development. A popular target for antibiotic development is DNA replication, as this is an essential process in bacterial cell development. Further understanding of the DNA replication process in mycobacteria will be key to drug development efforts. The process of DNA replication has been well studied in Escherichia coli and Bacillus …

Approved Programs 9-12-23, Angela Brock

Programs Committee (PC)

No abstract provided.

Programs Agenda 9-12-23, Angela Brock

Programs Committee (PC)

No abstract provided.

Make Your Work Accessible: Utilizing Digitalcommons@Uno And Uno's Open Access Publishing Agreements To Make Your Work Open And Accessible, Jennie Tobler-Gaston

Criss Library Faculty Proceedings & Presentations

This presentation cover UNO’s institutional repository, Digital Commons at UNO, how to deposit your scholarly work in the repository and the benefits of doing so, the basics and different types of open access, and the four Open Access Publishing Agreements that are available and their requirements so you can publish your work open access at no cost.

Program Review Report 9-12-23, Angela Brock

Program Review Committee

No abstract provided.