Digital Commons Network^™

Adjunctive Diagnostic Studies Completed Following Detection Of Candidemia In Children: Secondary Analysis Of Observed Practice From A Multicenter Cohort Study Conducted By The Pediatric Fungal Network, Rachel L Wattier, Robert F T Bucayu, Craig L K Boge, Rachael K Ross, Inci Yildirim, Theoklis E Zaoutis, Debra L Palazzi, Surabhi B Vora, Elio Castagnola, Martha Avilés-Robles, Lara Danziger-Isakov, Alison C Tribble, Tanvi S Sharma, Antonio C Arrieta, Gabriela Maron, David M Berman, Dwight E Yin, Lillian Sung, Michael Green, Emmanuel Roilides, Kiran Belani, José Romero, Pere Soler-Palacin, Eduardo López-Medina, Dawn Nolt, Ibrahim Zaid Bin Hussain, William J Muller, Sarmistha B Hauger, Natasha Halasa, Daniel Dulek, Alice Pong, Blanca E Gonzalez, Mark J Abzug, Fabianne Carlesse, Anna R Huppler, Sujatha Rajan, Catherine Aftandilian, Monica I Ardura, Arunaloke Chakrabarti, Benjamin Hanisch, Christine M Salvatore, Lena Klingspor, Elizabeth D Knackstedt, Irja Lutsar, Maria E Santolaya, Sydney Shuster, Sarah K Johnson, William J Steinbach, Brian T Fisher

Faculty, Staff and Students Publications

BACKGROUND: Adjunctive diagnostic studies (aDS) are recommended to identify occult dissemination in patients with candidemia. Patterns of evaluation with aDS across pediatric settings are unknown.

METHODS: Candidemia episodes were included in a secondary analysis of a multicenter comparative effectiveness study that prospectively enrolled participants age 120 days to 17 years with invasive candidiasis (predominantly candidemia) from 2014 to 2017. Ophthalmologic examination (OE), abdominal imaging (AbdImg), echocardiogram, neuroimaging, and lumbar puncture (LP) were performed per clinician discretion. Adjunctive diagnostic studies performance and positive results were determined per episode, within 30 days from candidemia onset. Associations of aDS performance with episode characteristics …

Examining Cancer Patients' Perceptions Of The Impact Of Covid-19 On Teleoncology: Findings From 15 Nigerian Outpatient Cancer Clinics, Adedayo Joseph, Abdul R. Shour, Nwamaka N. Lasebikan, Mutiu A. Jimoh, Bolanle C. Adegboyega, Emmanuella Nwachukwu, Opeyemi Awofeso, Azeezat Ajose, Abiola Ibraheem, Omolara Aminat Fatiregun, Musa Ali-Gombe, Usman M. Aliyu, Abdallah Elsaid Kotkat, Olusegun Abayomi Biyi-Olutunde, Evaristus Oseiwe Oboh, Ismail H. Zubairu, Mohammad Rifat Haider, Bankole Olatosi Ph.D., David Puthoff, Adedayo A. Onitilo

Faculty Publications

Purpose

To examine cancer patients' perspectives on the impact of COVID-19 on teleoncology in Nigeria.

Methods

Data from a multicenter survey conducted at 15 outpatient clinics to 1,097 patients with cancer from April and July 2020 were analyzed. The study outcome was telemedicine, defined as patients who reported their routine follow-up visits were converted to virtual visits because of COVID-19 (coded yes/no). Covariates included patient age, ethnicity, marital status, income, cancer treatment, service disruption, and cancer diagnosis/type. Stata/SE.v.17 (StataCorp, College Station, TX) was used to perform chi-square and logistic regression analyses. P values ≤ .05 were considered statistically significant.

Results …

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Cataloging Middle Eastern Non-Book Materials Using Rda And Marc21: Objects, Cyrus Ford Zarganj

Library Faculty Presentations

This workshop covers an introduction to cataloging objects using RDA standards and the MARC21 format. This workshop provides an introductory overview of cataloging objects using RDA standards and the MARC21 format. It covers a wide range of objects, including realia, toys, games, tactile three-dimensional forms, microscope slides, models, and dioramas. The workshop focuses on addressing the challenges and various aspects specific to cataloging objects.

A Prospective Randomized Clinical Trial To Assess Antibiotic Pocket Irrigation On Tissue Expander Breast Reconstruction, Jennifer N Walker, Blake M Hanson, Tayler Hunter, Shelby R Simar, Jesus M Duran Ramirez, Chloe L P Obernuefemann, Rajiv P Parikh, Marissa M Tenenbaum, Julie A Margenthaler, Scott J Hultgren, Terence M Myckatyn

Faculty, Staff and Student Publications

Bacterial infection is the most common complication following staged post-mastectomy breast reconstruction initiated with a tissue expander (TE). to limit bacterial infection, antibiotic irrigation of the surgical site is commonly performed despite little high-quality data to support this practice. We performed a prospective randomized control trial to compare the impact of saline irrigation alone to a triple antibiotic irrigation regimen (1 g cefazolin, 80 mg gentamicin, and 50,000 units of bacitracin in 500 mL of saline) for breast implant surgery. The microbiome in breasts with cancer (

Genome Sequences Of Six Cluster Ct And Two Cluster Dj Bacteriophages That Infect Gordonia Rubripertincta, Xavier F. Rodriguez, Daniel C. Williams, Catherine P. Chia

School of Biological Sciences: Faculty Publications

We report the genome sequences of eight bacteriophages isolated using Gordonia rubripertincta NRRL B-16540-SEA. Based on gene content similarity to phages in the Actinobacteriophage database, six of the phages are assigned to phage cluster CT while two are assigned to cluster DJ.

Design And Synthesis Of Chiral, Conformationally Constrained Fatty Acid Mimetics, Lauren Elizabeth Markham Ph.D.

Dartmouth College Ph.D Dissertations

Fatty acids interact with a wide variety of proteins, as they are either directly or indirectly involved in essentially every physiological process. Mimetics of these fatty acids have the potential to address unique issues associated with these proteins, in ways that the native ligands cannot. The pharmacological panel of targets for fatty acid mimetics is very large and comprises nuclear hormone receptors, cell surface receptors, and enzymes. This thesis describes approaches to the design and synthesis of novel fatty acid mimetics. Specifically, techniques introducing chirality and conformational constraints are employed to produce potent and selective modulators of various receptors. Synthetically, …

Spectrum, Volume 51, Issue 3, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: The Results Are In: New Faces of Student Government -- Hacking the Constitution -- Cheers, Beers, Pioneers: “Pack the Pub” at Red’s -- Behind the Seams: Fashion Club Visits Mitchell’s -- Book Talk: Editors^ Picks -- Arts and Entertainment: Hollywood on Hold -- The Rising Stars of the Sports Media Word

Differential Effects Of Pancreatic Cancer-Derived Extracellular Vesicles Driving A Suppressive Environment, Anurag Purushothaman, Jacqueline Oliva-Ramírez, Warapen Treekitkarnmongkol, Deivendran Sankaran, Mark W Hurd, Nagireddy Putluri, Anirban Maitra, Cara Haymaker, Subrata Sen

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) cells display extensive crosstalk with their surrounding environment to regulate tumor growth, immune evasion, and metastasis. Recent advances have attributed many of these interactions to intercellular communication mediated by small extracellular vesicles (sEVs), involving cancer-associated fibroblasts (CAF). To explore the impact of sEVs on monocyte lineage transition as well as the expression of checkpoint receptors and activation markers, peripheral blood monocytes from healthy subjects were exposed to PDAC-derived sEVs. Additionally, to analyze the role of sEV-associated HA in immune regulation and tissue-resident fibroblasts, monocytes and pancreatic stellate cells were cultured in the presence of PDAC sEVs …

Streamlining The Detection Of Human Thyroid Receptor Ligand Interactions With Xl1-Blue Cell-Free Protein Synthesis And Beta-Galactosidase Fusion Protein Biosensors, J. Porter Hunt, Tyler J. Free, Jackelyn Galiardi, Kevin M. Watt, David W. Wood, Bradley Charles Bundy

Faculty Publications

Thyroid receptor signaling controls major physiological processes and disrupted signaling can cause severe disorders that negatively impact human life. Consequently, methods to detect thyroid receptor ligands are of great toxicologic and pharmacologic importance. Previously, we reported thyroid receptor ligand detection with cell-free protein synthesis of a chimeric fusion protein composed of the human thyroid receptor beta (hTRβ) receptor activator and a β-lactamase reporter. Here, we report a 60% reduction in sensing cost by reengineering the chimeric fusion protein biosensor to include a reporter system composed of either the full-length beta galactosidase (β-gal), the alpha fragment of β-gal (β-gal-α), or a …

Kernel Density Estimation Of Conditional Distributions To Detect Responses In Satellite Tag Data, Joshua Hewitt, Alan E. Gelfand, Nicola J. Quick, William R. Cioffi, Brandon L. Southall, Stacy L. Deruiter, Robert S. Schick

School of Biological and Marine Sciences

Background As levels of anthropogenic noise in the marine environment rise, it is crucial to quantify potential associated effects on marine mammals. Yet measuring responses is challenging because most species spend the majority of their time submerged. Consequently, much of their sub-surface behavior is difficult or impossible to observe and it can be difficult to determine if—during or following an exposure to sound—an observed dive differs from previously recorded dives. We propose a method for initial assessment of potential behavioral responses observed during controlled exposure experiments (CEEs), in which animals are intentionally exposed to anthropogenic sound sources. To identify possible …

Propofol Affords No Protection Against Delayed Cerebral Ischemia In A Mouse Model Of Subarachnoid Hemorrhage, Meizi Liu, Keshav Jayaraman, James W Nelson, Jogender Mehla, Deepti Diwan, Ananth K Vellimana, Gregory J Zipfel, Umeshkumar Athiraman

2020-Current year OA Pubs

Delayed cerebral ischemia (DCI) is an important contributor to poor outcomes in aneurysmal subarachnoid hemorrhage (SAH) patients. We previously showed that volatile anesthetics such as isoflurane, sevoflurane and desflurane provided robust protection against SAH-induced DCI, but the impact of a more commonly used intravenous anesthetic agent, propofol, is not known. The goal of our current study is to examine the neurovascular protective effects of propofol on SAH-induced DCI. Twelve-week-old male wild-type mice were utilized for the study. Mice underwent endovascular perforation SAH or sham surgery followed one hour later by propofol infusion through the internal jugular vein (2 mg/kg/min continuous …

Methamphetamine-Induced Region-Specific Transcriptomic And Epigenetic Changes In The Brain Of Male Rats, Benpeng Miao, Xiaoyun Xing, Viktoriia Bazylianska, Pamela Madden, Anna Moszczynska, Bo Zhang

2020-Current year OA Pubs

Psychostimulant methamphetamine (METH) is neurotoxic to the brain and, therefore, its misuse leads to neurological and psychiatric disorders. The gene regulatory network (GRN) response to neurotoxic METH binge remains unclear in most brain regions. Here we examined the effects of binge METH on the GRN in the nucleus accumbens, dentate gyrus, Ammon's horn, and subventricular zone in male rats. At 24 h after METH, ~16% of genes displayed altered expression and over a quarter of previously open chromatin regions - parts of the genome where genes are typically active - showed shifts in their accessibility. Intriguingly, most changes were unique …

Author Correction: Histone H2a Lys130 Acetylation Epigenetically Regulates Androgen Production In Prostate Cancer, Thanh Nguyen, Dhivya Sridaran, Surbhi Chouhan, Cody Weimholt, Audrey Wilson, Jingqin Luo, Tiandao Li, John Koomen, Bin Fang, Nagireddy Putluri, Arun Sreekumar, Felix Y Feng, Kiran Mahajan, Nupam P Mahajan

Faculty, Staff and Students Publications

No abstract provided.

The Folly Of The Expanded Maternity Leave Law, Emily Sanchez Salcedo

Center for Business Research and Development

The recent enactment of Republic Act No. 11210, otherwise known as the “105-Day Expanded Maternity Leave Law,” on February 20, 2019 was well applauded by women’s groups and their supporters. The Philippine Commission on Women welcomed the signing of the law as a “gift for Filipino women and families” as it “recognizes and acknowledges women’s vital role and contribution to the labor force, while giving them the opportunity to exercise their unique reproductive role.”1 The Gabriela Women’s Party lauded the passage of the law more than ten years since they filed the original bill in 2008 “as a significant move …

The Effects Of Resistance Training On Jumping And Selected Power Variables Of The Lower Limbs In Female Soccer Players, Tomasz Chamera, Magdalena Prończuk, Piotr Smok, Miłosz Drozd, Małgorzata Michalczyk, Adam Maszczyk

Baltic Journal of Health and Physical Activity

Introduction: The aim of the study was to compare the effects of a 6-week intervention of combined soccer training with resistance training on strength and power variables in highly trained female soccer players. It was hypothesized that 6 weeks is sufficient for a significant improvement in jumping ability and power to occur due to the intervention. The study involved 34 female soccer players of the top women’s league (22 ± 5 years old, body height 167 ± 5 cm, body weight 60 ± 8 kg). The players were divided into two groups of 17 participants. The control group performed 3 …

The Image Of Women As Victims In F. Scott Fitzgerald’S The Great Gatsby, Nouh Al-Guzo

Jordan Journal of Applied Science-Humanities Series

This paper sheds light on the image of women as victims in the male-dominant society of America in the 1920s through a critical analysis of Francis Scott Fitzgerald’s novel, The Great Gatsby. The three main female characters in the narrative—Daisy Buchanan, Myrtle Wilson, and Jordan Baker—are products of oppressive forces and are treated by powerful men as objects rather than as thoughtful beings. The belief held by these characters that marriage to wealthy men is one of the few options available for women to achieve success and happiness makes them victims of the advances of morally corrupt men who …

Multi-Criteria Analysis Of The Possibility Of Retrofitting The System Of Rainwater Drainage From Subsidence Basins In A Liquidated Mine, Andrzej Chmiela, Małgorzata Wysocka, Adam Smoliński

Journal of Sustainable Mining

Mine closure is the natural final stage of mining activity. The process of financing mine liquidation is complex and expensive. The many years of conducted hard coal extraction affect the surface height differences. Analyses of the shifts in hydrogeological conditions and water hazard states in mining plants led to legal regulation adaptations, primarily in terms of hydrogeological documentation preparation, and made it necessary to conduct work concerning new options for water hazard assessment and prevention. Current subjects of particular interest include shifts in terrain morphology and the water regime, resulting in periodic flooding and permanent flooding of the most depressed …

Response Of Lake Metabolism To Catchment Inputs Inferred Using High-Frequency Lake And Stream Data From Across The Northern Hemisphere, Jessica R. Corman, Jacob A. Zwart, Jennifer Klug, Denise A. Bruesewitz, Elvira De Eyto, Marcus Klaus, Lesley B. Knoll, James A. Rusak, Michael J. Vanni, María Belén Alfonso, Rocio Luz Fernandez, Huaxia Yao, Kari Austnes, Raoul-Marie Couture, Heleen A. De Wit, Jan Karlsson, Alo Laas

School of Natural Resources: Faculty Publications

In lakes, the rates of gross primary production (GPP), ecosystem respiration (R), and net ecosystem production (NEP) are often controlled by resource availability. Herein, we explore how catchment vs. within lake predictors of metabolism compare using data from 16 lakes spanning 39^oN to 64^oN, a range of inflowing streams, and trophic status. For each lake, we combined stream loads of dissolved organic carbon (DOC), total nitrogen (TN), and total phosphorus (TP) with lake DOC, TN, and TP concentrations and high frequency in situ monitoring of dissolved oxygen. We found that stream load stoichiometry indicated lake stoichiometry …

Executive Committee - Agenda 9/26/2023, Academic Senate

Academic Senate Agendas

No abstract provided.

Fundamental Study Of Ionic Liquid Physicochemical Effects On Thermal Stability Of Model Biological Macromolecules, Austin Keith Clark

Theses and Dissertations

Ionic Liquids (ILs) are substances with a unique physical attribute compared to that of solid ionic salts. At room temperature, ILs are molten salts that have a variety of physical effects that can play a role in their impact on other molecules, as solvents or solutes. They can play the role of the solvent in a variety of applications, from biofuels to organic catalysis or as excipients in pharmaceutical formulations. These ILs have a desirable use as solvents due to their ability to be tunable substances. Changing the cation or anion of the IL causes a change in its physical …

September 26, 2023, Nichole Mulvey

Minutes

Volume 52, Number 3

Speakers: Dean of Library Services Brian Keith and Faculty Development and Innovation Center Director Michael Gillespie

Two New Species Of Tulostoma (Agaricales, Basidiomycota) From The Neotropics, Alexandro Lima, Gislaine Melanda, Paulo Marinho, T A, María Paz Martín, Iuri Baseia

Turkish Journal of Botany

Tulostoma catimbauense and T. deltaconcavum, both collected from Neotropical region, in the Vale do Catimbau National Park, Brazil, are proposed as new to science. Detailed macro- and micromorphological descriptions, including scanning electron microscopy of the basidiospores, are provided. ITS nrDNA sequence analyses were used to investigate the phylogenetic position of these taxa in the genus Tulostoma. Discussions about related species were carried out.

The Perceived Usability Of Virtual Visits Among Black Adults' Receiving Oncology Care: A Qualitative Analysis, Samantha Tam, Christine Neslund-Dudas, Amy M. Barrett, Lauren C. J Barrow, Ilona Fridman, Alan C. Kinlaw, Praveen Puviindran, Trevor J. Royce, Angela B. Smith, Jacob N. Stein, William A. Wood, Jennifer Elston Lafata

Otolaryngology Articles

BACKGROUND: With the COVID-19 pandemic came rapid uptake in virtual oncology care. During this, sociodemographic inequities in access to virtual visits (VVs) have become apparent. To better understand these issues, we conducted a qualitative study to describe the perceived usability and acceptability of VVs among Black adults diagnosed with cancer.

METHODS: Adults who self-identified as Black and had a diagnosis of prostate, multiple myeloma, or head and neck cancer were recruited from 2 academic medical centers, and their community affiliates to participate in a semi-structured interview, regardless of prior VV experience. A patient and family advisory board was formed to …

Putative Photosensitivity In Internal Light Organs (Organs Of Pesta) Of Deep-Sea Sergestid Shrimps, Tamara Frank, Jamie Sickles, Danielle M. Deleo, Patricia Blackwelder, Heather Bracken-Grissom

Marine & Environmental Sciences Faculty Articles

Many marine species can regulate the intensity of bioluminescence from their ventral photophores in order to counterilluminate, a camoufage technique whereby animals closely match the intensity of the downwelling illumination blocked by their bodies, thereby hiding their silhouettes. Recent studies on autogenic cuticular photophores in deep-sea shrimps indicate that the photophores themselves are light sensitive. Here, our results suggest photosensitivity in a second type of autogenic photophore, the internal organs of Pesta, found in deep-sea sergestid shrimps. Experiments were conducted onboard ship on live specimens, exposing the animals to bright light, which resulted in ultrastructural changes that matched those seen …

Determination Of The Genetic Diversity, Population Structure, And Some Ecological Preferences Of The Endemic Muscari Adilii, Ali̇ Murat Keser, Ahmet Emre Yaprak, Gül Ni̇lhan Tuğ

Turkish Journal of Botany

The population structure and genetic diversity of M. adilii and some edaphic and climatic preferences of the species were investigated. Although the chemical characteristics such as pH, EC, and gypsum were similar for the three subpopulations, the physical qualities and lime content of the soil were different from each other. In terms of bioclimate, the Nallıhan station (Nallıhan Bird Sanctuary) has a lower annual average temperature and precipitation value, and monthly average values during the germination and flowering periods, than the Beypazarı station (Hırkatepe and Çoban Ahmet Fountain). Amplification with 16 ISSR markers produced 377 bands from 84 individuals belonging …

Exogenous Ketone Supplements For Reducing Anxiety-Related Behavior, Csilla Ari D'Agostino, Dominic Paul D'Agostino

USF Patents

Methods of treating anxiety disorders or reducing anxiety-related behaviors. The methods include administering a therapeutically effective amount of ketone supplementation, such as butanediol, ketone esters (e.g., 1,3-butanediol-acetoacetate diester) and/or ketone salts (e.g., beta-hydroxybutyrate-mineral salt), chronically, sub-chronically, or acutely, with or without admixture with a medium chain triglyceride or in combination. It was determined herein that ketone supplementation reduced anxiety in rats on elevated plus maze as measured by less entries to closed arms, more time spent in open arms, more distance travelled in open arms, and delayed latency to entrance to closed arms, when compared to control. Along with reducing …

Galloylated Procyanidins For Treating Endovascular Dysfunction And Increasing Blood Flow, Michael Louis Sperduti, Matthew Cleary Nickerson, Jimmy Roy Huddleston, Leigh Anthony West

USF Patents

The present disclosure is directed to compositions, methods of use, and methods of making, wherein the compositions contain one or more galloylated procyanidins having between two and five epicatechin monomers, wherein the one or more galloylated procyanidins include epicatechin-(4-8)-epicatechin-(4-8)-epicatechin-gallate, catechin trimer gallate, catechin dimer digallate, or combinations thereof.

Pollen Morphology Of Some Tanacetum L. (Asteraceae) Taxa And Its Systematic Value, Murat Kurşat, İsmai̇l Çelti̇k, Bi̇rol Başer, Fahretti̇n Özbey, İrfan Emre

Turkish Journal of Botany

Pollen grains of 24 Tanacetum taxa from Türkiye were examined by light (LM) and scanning electron microscopy (SEM). Detailed pollen morphological characteristics are provided for these taxa. According to the 24 analyzed taxa, T. parthenifolium has the smallest pollen grains, and T. aurem var. aurem possesses the largest ones. The basic shape of the pollen grains in most taxa is oblatespheroidal. However, suboblate pollen grains are recorded for T. balsamitoides, T. aurem var. aurem, and T. tomentellum. The polar axis ranges from 16.56 to 26.14 µm, and the equatorial diameter ranges from 17.64 to 30.12 µm in this study. …

A New Scrophularia (Scrophulariaceae) Species Without Staminodes In The Enigmatic ?Canina Clade? From The Western Taurus (Türkiye), Candan Aykurt, Mertcan Gülben, Bariş Özüdoğru, Duygu Sari, İsmai̇l Gökhan Deni̇z, Burçi̇n Çingay

Turkish Journal of Botany

The new species of Scrophularia was discovered among the screes and stony slopes of the Alakır Valley (Antalya) located in the Western Taurus. The most remarkable morphological feature of the species is its flowers without staminodes. With this feature, the species is unique among the representatives of the ?Canina? clade in Türkiye. The new species is closely related to S. floribunda endemic to Türkiye and East Aegean Islands (Greece) according to our phylogenetic analyses based on the nuclear ITS and chloroplast trnL-F regions. Apart from its corollas without staminodes, the new species differs from its morphologically similar …

Comparative Skull Morphology Of California Sea Lions (Zalophus Californianus) And Steller Sea Lions (Eumetopias Jubatus) In The Pacific Northwest And Implications For Hybridization, Ada Iris Garcia Garcia

Dissertations and Theses

Eumetopias jubatus (Steller sea lions) that breed on the Oregon coast are smaller than those found both in Alaska and California. During the breeding season, male Zalophus californianus (California sea lions) move past E. jubatus rookeries in Oregon on their way to their breeding rookeries in Southern California. Introgression potentially could explain the difference in size of Oregon E. jubatus relative to remaining populations. At Portland State University (PSU), the marine mammal collection of the Museum of Vertebrate Biology has over 200 skulls of Z. californianus and E. jubatus from throughout northern Oregon and southern Washington. To assess whether morphologically …