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Turkish Journal of Biology

No abstract provided.

Gooseberry Anthocyanins Alleviate Insulin Resistance By Regulating Ceramide Metabolism In High Fat Diet Mice, Xian Tang, Jun Gao, Jinpeng Huang, Chenjuan Zhang, Hongwei Liu, Jie Wei

Turkish Journal of Biology

Background/aim: Obesity is the fifth largest risk factor of death in the world. The ceramide produced by obesity is closely related to insulin resistance (IR) caused by obesity. At present, the commercially available weight loss products have large side effects and limited therapeutic effects. Therefore, it is particularly important to find effective natural nontoxic products to treat obesity and explore its possible pathways and mechanisms. Materials and methods: In this paper, a high-fat diet (HFD) mice model was established by intragastric administration of high-fat emulsion to investigate the intervention effect of Gooseberry anthocyanins (GA) on IR in HFD mice. We …

Exploring Breast Cancer Systemic Drug Therapy Patterns In Real-World Data, Julia O'Rourke, Jeff Warnick, John Doole, Luc De Keyser, Zuzanna Drebert, Olivia Wan, Courtney N Thompson, Jack W. London, Karen Fairchild, Matvey B. Palchuk

Kimmel Cancer Center Faculty Papers

PURPOSE: To explore medications and their administration patterns in real-world patients with breast cancer.

METHODS: A retrospective study was performed using TriNetX, a federated network of deidentified, Health Insurance Portability and Accountability Act-compliant data from 21 health care organizations across North America. Patients diagnosed with breast cancer between January 1, 2013, and May 31, 2022, were included. We investigated a rule-based and unsupervised learning algorithm to extract medications and their administration patterns. To group similar administration patterns, we used three features in k-means clustering: total number of administrations, median number of days between administrations, and standard deviation of the days …

2023-10-18 Mariners Miss Playoffs Again, Fans Still Hopeful For Future, Marisa Sexsmith

The Spectator Online

No abstract provided.

Ribosomal Protein L8 Regulates The Expression And Splicing Pattern Of Genes Associated With Cancer-Related Pathways, Leilei Xu, Gui Yang, Bin Song, Dong Chen, Akbar. Yunus, Jiangtao Chen, Xiaogang Yang, Zheng Tian

Turkish Journal of Biology

Background/aim: Ribosomal proteins have been shown to perform unique extraribosomal functions in cell apoptosis and other biological processes. Ribosomal protein L8 (RPL8) not only has important nonribosomal regulatory functions but also participates in the oncogenesis and development of tumors. However, the specific biological functions and pathways involved in this process are still unknown. Materials and methods: RPL8 was overexpressed (RPL8-OE) in HeLa cells. MTT assay and flow cytometry were used to detect cell proliferation and apoptosis, respectively. Transcriptome sequencing was performed to analyze the differentially expressed genes (DEGs) and regulated alternative splicing events (RASEs) by RPL8-OE, both of which were …

Braf D594a Mutation Defines A Unique Biological And Immuno-Modulatory Subgroup Associated With Functional Cd8+ T Cell Infiltration In Colorectal Cancer, Wenjing Li, Chenyi Zhao, Wenhui Li, Yang Gong, Kaili Ma, Yujie Lu, Xiaowei Liu, Lianjun Zhang, Feng Guo

Faculty, Staff and Student Publications

BACKGROUND: BRAF non-V600 mutation occupies a relatively small but critical subset in colorectal cancer (CRC). However, little is known about the biological functions and impacts of BRAF class III mutation in CRC. Here, we aim to explore how D594A mutation impacts on biological behaviors and immune related signatures in murine CRC cells.

METHODS: BRAF V600E (class I), G469V (class II) and D594A (class III) mutant cell lines were established based on MC38 cells. The biological behaviors of cells were evaluated in respect of cell growth, cell proliferation, cell apoptosis, cell migration and invasion by the methods of colony-forming assay, CCK-8 …

Editorial: Debates In Cardiovascular Pharmacology And Drug Discovery: 2022, Keman Xu, Fatma Saaoud, Ying Shao, Yifan Lu, Xiaohua Jiang, Sheng Wu, Jianxin Sun, Filipe Fernades Conti, Laisel Martinez, Roberto Vazquez-Padron, Hong Wang, Xiaofeng Yang

Center for Translational Medicine Faculty Papers

No abstract provided.

Minutes From October 18 2023, University Senate

University Senate Minutes

Minutes from October 18 2023 University Senate Meeting

Genetic Analysis Of Basal Stalk Rot Resistance Introgressed From Wild Helianthus Petiolaris Into Cultivated Sunflower (Helianthus Annuus L.) Using An Advanced Backcross Population, Zahirul I. Talukder, William Underwood, Christopher G. Misar, Xuehui Li, Gerald J. Seiler, Xiwen Cai, Lili Qi

Department of Agronomy and Horticulture: Faculty Publications

Introduction: Sclerotinia sclerotiorum is a serious pathogen causing severe basal stalk rot (BSR) disease on cultivated sunflower (Helianthus annuus L.) that leads to significant yield losses due to insufficient resistance. The wild annual sunflower species H. petiolaris, commonly known as prairie sunflower is known for its resistance against this pathogen. Sunflower resistance to BSR is quantitative and determined by many genes with small effects on the resistance phenotype. The objective of this study was to identify loci governing BSR resistance derived from H. petiolaris using a quantitative trait loci (QTL) mapping approach.

Methods: BSR …

The Association Of Research Quantitative Measures With Faculty Ranks Of Australian And New Zealand Dental Schools, Ayesha Fahim, Sadia Shakeel, Farhan Saleem, Ijaz Ur Rehman, Kashif Siddique, Habib Ahmad Qureshi, Muhammad Sohail Zafar

Research outputs 2022 to 2026

Introduction: The scholarly productivity of a faculty member can be measured through several indicators including annual appraisals, feedback, and the number of publications per year. The present study aims to assess the association of quantitative research measures and academic ranks in Australian and New Zealand dental schools. Methods: It was an analytical observational cross-sectional study. Full-time faculty members working in Australia and New Zealand's dental schools were discovered on official websites. Various bibliometric parameters including h-index, total number of citations, total number of publications, and maximum number of sources of a single publication were analyzed. Spearman rank correlation was used …

Winonan, Winona State University

The Winonan - 2020s

This issue of the Winonan, the Winona State University student newspaper, was published on October 18, 2023.

Depth And Frequency Dependence Of Geoacoustic Properties On The New England Mud Patch From Reflection Coefficient Inversion, Jiang Yong-Min, Charles W. Holland, Stan E. Dosso, Jan Dettmer

Electrical and Computer Engineering Faculty Publications and Presentations

Muddy sediments cover significant portions of continental shelves, but their physical properties remain poorly understood compared to sandy sediments. This paper presents a generally applicable model for sediment-column structure and variability on the New England Mud Patch (NEMP), based on trans-dimensional Bayesian inversion of wide-angle, broadband reflection-coefficient data in this work and in two previously published reflection-coefficient inversions at different sites on the NEMP. The data considered here include higher frequencies and larger bandwidth and cover lower reflection grazing angles than the previous studies, hence, resulting in geoacoustic profiles with significantly better structural resolution and smaller uncertainties. The general sediment-column …

Microbial Community Function And Bacterial Pathogen Composition In Pit Latrines In Peri-Urban Malawi., Savanna K. Smith, Benjamin B. Risk, Rochelle H. Holm, Elizabeth Tilley, Petros Chigwechokha, Drew Capone, Joe Brown, Francis L. De Los Reyes Iii

Faculty and Staff Scholarship

Despite the widespread global reliance on pit latrines as improved sanitation systems, the decomposition of waste within pit latrines is poorly understood. One area needing elucidation is the characterization and function of microbial communities within pit latrines. To address this gap, we characterized the microbial communities of 55 lined pit latrines at three sampling layers from two communities in peri-urban Malawi. The microbial communities of the fecal sludge samples were analyzed for beta diversity, pathogen presence, and functional profiling. Household surveys were conducted and used to compare microbial community patterns to household characteristics and pit latrine use patterns. Compared to …

Law And Its Limits: Ethical Issues In Mary Shelley’S Frankenstein Or, The Modern Prometheus, David S. Caudill

St. Mary's Journal on Legal Malpractice & Ethics

The law and literature movement is frequently associated with the use of literary images of law as a point of reflection upon the ethical obligations of lawyers. Mary Shelley’s Frankenstein (1818)—the story of a young scientist whose unorthodox experiments end up creating the famed “monster”—is not, at first glance, a likely candidate for that enterprise. However, Dr. Frankenstein’s ambition and ruthless pursuit of knowledge has become a contemporary image of science out of control and the need for ethical limitations on scientific progress. Consequently, the novel raises currently important issues of regulating science and technology. Given the lawyer’s ethical obligation …

Outbreak Investigation Of Ndm-Producing Burkholderia Cepacia Causing Neonatal Sepsis In Pakistan, A Batool, A Yakoob, Zahid Anwar, Lovleen Tina Joshi, Durreshahwar Lone, Qasim Ahmed, Muhammad Usman Qamar, Ramsha Batool, Zikria Saleem, Yousef Bin Jardan, Mohammed Bourhia

Peninsula Dental School

Aim: To investigate the outbreak of Burkholderia cepacia complex (BCC), mortality, antimicrobial resistance and associated risk factors in the neonatal intensive care unit. Method: Eighteen blood culture samples from neonates and twenty swab samples from different neonatal intensive care unit surfaces were collected. The VITEK 2 was used to confirm the isolates and generate the antibiogram. PCR was used to identify blaNDM. Results: Eighteen samples tested positive for BCC, and 10/18 (55.5%) of the neonates died. 13/18 (72%) of the neonates had late-onset neonatal sepsis, and 10/18 (55%) had low birth weight. Resistance to minocycline and chloramphenicol was 100%, 72.2% …

Law And Its Limits: Ethical Issues In Mary Shelly's Frankenstein Or, The Modern Prometheus, David S. Caudill

Faculty Publications

The law and literature movement is frequently associated with the use of literary images of law as a point of reflection upon the ethical obligations of lawyers. Mary Shelley’s Frankenstein (1818)—the story of a young scientist whose unorthodox experiments end up creating the famed “monster”—is not, at first glance, a likely candidate for that enterprise. However, Dr. Frankenstein’s ambition and ruthless pursuit of knowledge has become a contemporary image of science out of control and the need for ethical limitations on scientific progress. Consequently, the novel raises currently important issues of regulating science and technology. Given the lawyer’s ethical obligation …

Biomechanical Origins Of Proprioceptor Feature Selectivity And Topographic Maps In The Drosophila Leg, Akira Mamiya, Anne Sustar, Igor Siwanowicz, Yanyan Qi, Tzu-Chiao Lu, Pralaksha Gurung, Chenghao Chen, Jasper S Phelps, Aaron T Kuan, Alexandra Pacureanu, Wei-Chung Allen Lee, Hongjie Li, Natasha Mhatre, John C Tuthill

Faculty, Staff and Students Publications

Our ability to sense and move our bodies relies on proprioceptors, sensory neurons that detect mechanical forces within the body. Different subtypes of proprioceptors detect different kinematic features, such as joint position, movement, and vibration, but the mechanisms that underlie proprioceptor feature selectivity remain poorly understood. Using single-nucleus RNA sequencing (RNA-seq), we found that proprioceptor subtypes in the Drosophila leg lack differential expression of mechanosensitive ion channels. However, anatomical reconstruction of the proprioceptors and connected tendons revealed major biomechanical differences between subtypes. We built a model of the proprioceptors and tendons that identified a biomechanical mechanism for joint angle selectivity …

Standardization Of An Antiviral Pipeline For Human Norovirus In Human Intestinal Enteroids Demonstrates Nitazoxanide Has No To Weak Antiviral Activity, Miranda A Lewis, Nicolás W Cortés-Penfield, Khalil Ettayebi, Ketki Patil, Gurpreet Kaur, Frederick H Neill, Robert L Atmar, Sasirekha Ramani, Mary K Estes

Faculty, Staff and Students Publications

Human noroviruses (HuNoVs) are the leading cause of acute gastroenteritis. In immunocompetent hosts, symptoms usually resolve within 3 days; however, in immunocompromised persons, HuNoV infection can become persistent, debilitating, and sometimes life-threatening. There are no licensed therapeutics for HuNoV due to a near half-century delay in its cultivation. Treatment for chronic HuNoV infection in immunosuppressed patients anecdotally includes nitazoxanide, a broad-spectrum antimicrobial licensed for treatment of parasite-induced gastroenteritis. Despite its off-label use for chronic HuNoV infection, nitazoxanide has not been clearly demonstrated to be an effective treatment. In this study, we standardized a pipeline for antiviral testing using multiple human …

Reprogramming Of Cis-Regulatory Networks During Skeletal Muscle Atrophy In Male Mice, Hongchun Lin, Hui Peng, Yuxiang Sun, Meijun Si, Jiao Wu, Yanlin Wang, Sandhya S Thomas, Zheng Sun, Zhaoyong Hu

Faculty, Staff and Students Publications

A comprehensive atlas of cis-regulatory elements and their dynamic activity is necessary to understand the transcriptional basis of cellular structure maintenance, metabolism, and responses to the environment. Here we show, using matched single-nucleus chromatin accessibility and RNA-sequencing from juvenile male C57BL6 mice, an atlas of accessible chromatin regions in both normal and denervated skeletal muscles. We identified cell-type-specific cis-regulatory networks, highlighting the dynamic regulatory circuits mediating transitions between myonuclear types. Through comparison of normal and perturbed muscle, we delineated the reprogramming of cis-regulatory networks in response to denervation, described the interplay of promoters/enhancers and target genes. We further unveil a …

Burosumab Vs Phosphate/Active Vitamin D In Pediatric X-Linked Hypophosphatemia: A Subgroup Analysis By Dose Level, Erik A Imel, Michael P Whyte, Andrew Biggin, Et Al.

2020-Current year OA Pubs

CONTEXT: In an open-label, randomized, controlled, phase 3 trial in 61 children aged 1 to 12 years with X-linked hypophosphatemia (XLH), burosumab improved rickets vs continuing conventional therapy with active vitamin D and phosphate.

OBJECTIVE: We conducted an analysis to determine whether skeletal responses differed when switching to burosumab vs continuing higher or lower doses of conventional therapy.

METHODS: Conventional therapy dose groups were defined as higher-dose phosphate [greater than 40 mg/kg] (HPi), lower-dose phosphate [40 mg/kg or less] (LPi), higher-dose alfacalcidol [greater than 60 ng/kg] or calcitriol [greater than 30 ng/kg] (HD), and lower-dose alfacalcidol [60 ng/kg or less] …

Queering Ecology: Three Investigations From Indigenous Women In Post-Conflict North Sumatra, Perdana Roswaldy

Antropologi Indonesia

Feminists and environmental scholars draw connections between gender inequality, heterosexism, and the devastating impact of environmental catastrophes on the livelihoods of women and gender minorities, exacerbating their precarity. This body of scholarship has begun to imagine alternatives to patriarchal gender and heterosexual norms for reconciling the relationship between humans and nature by calling for "queer(ing) ecology." I investigate the possibility of queering ecology by posing three theoretical concerns in opposition to anthropocentric and gendered preconceptions about nature: its idleness, naturality, and rightfulness. Respectively, I will dissect such presumptions by questioning nature as metaphors, investigating "the natural" attribute in nature, and …

The Green Encounters: “Common Good” Narrative And Community Struggle In Halimun Salak Coridor, West Java, Sulastri Sardjo

Antropologi Indonesia

Since the colonial era of the East Indies, multiple ruling regimes have promoted a certain narrative to utilize the forests on Mount Halimun Salak for nature preservation and profit accumulation. Existing studies of the designation of Halimun Salak as a conservation area have shown that such an establishment led to conflicts over land and livelihoods with the surrounding communities and local farmers. Complementing these studies, my qualitative research in the Halimun Salak Corridor (HSC) highlights that the “common good” narrative promoted by conservation programs has not benefited people’s livelihoods. Conversely, the expansion of conservation area through HSC has further restricted …

The Question Of Qualia, Jonathan Mckinney '22

Furman Humanities Review

No abstract provided.

Pfas Screening And Protein Absolute Quantitation By Mass Spectrometry, Hao Chen

Sustainability Seminar Series

In collaboration with Prof. Mengyan Li at NJIT, we recently developed a rapid analytical method for per and polyfluoroalkyl substances (PFASs) using nano-electrospray high-resolution mass spectrometry (Nano-ESI-HRMS), which was recently published in Water Research, 2022, 219, 118542. This method was applied to aqueous film-forming foams (AFFFs) and wastewater samples collected from three local wastewater treatment plants (WWTPs). The method exhibited high sensitivity with lower limits of detection (LODs) of 3.2~36.2 ng/L for 22 target PFAS analytes. In AFFF formulations, Nano-ESI-HRMS enabled the first-time detection of trifluoromethanesulfonic acid (TFMS), perfluoroethyl cyclohexanesulfonate (PFECHS), 6:2 fluorotelomer sulfonyl amido sulfonic acid (6:2 FTSAS-SO2), N …

Surface Water Quality: Contaminants And Treatment, Juliana Grigg, Kathryn Jordan, Diana Montoya-Herrera, Frank Jacobitz

Creative Collaborations: Annual Showcase of Undergraduate Research

Extensive population growth and urbanization is affecting surface water quality and infrastructure across the globe. Urbanization was boosted by the advancements of infrastructure for water, which allows treatment and transport of water through large distances from their original surface water sources such as lakes, rivers, and streams. A major concern of the rapid changes experienced by urban areas is the ecological impacts on surface water due to associated anthropogenic processes. Activities such as the overconsumption and extraction of surface water have negatively affected the quality and quantity of those sources. In addition, discharge of treated wastewater may impact the quality …

Differential Dynamic Microscopy Enhanced With Convolutional Neural Networks, Steven Dang, Justin Siu, Ruilin You, Philip Neill, Ryan Mcgorty

Creative Collaborations: Annual Showcase of Undergraduate Research

Optical microscopy methods are commonly employed to measure rheological properties, like viscosity or viscoelasticity, of materials from biological tissues to colloidal suspensions. Such rheological properties are important for applications such as formulating pharmaceutical ointments to tailoring the mouthfeel of foods and for answering many fundamental questions such as how phase separation proceeds and how the material properties of the cytoplasm respond to stimuli. In recent years, an optical microscopy technique for performing rheological measurements known as differential dynamic microscopy (DDM) has grown in popularity. However, a drawback of DDM is that one typically needs to acquire movies of ~1000 frames …

The Shared Experiences Of Educators In Grades 7–12 Who Implement Lessons In Social–Emotional Learning Curriculum, Heathre C. Palige

Doctor of Education Program Dissertations

Social–emotional learning (SEL) is used in public school classrooms throughout the United States. The problem that this researcher addressed in this study was that minimal understanding exists of the lived experiences of teachers who implement SEL in Colorado public schools in Grades 7–12. The purpose of this qualitative phenomenological study was to explore and to provide a clearer understanding of the lived experiences of six educators who implement SEL in Grades 7–12 in Colorado public schools. The study fills a gap in literature in understanding the experiences of teachers who use SEL in middle and high school. The literature review …

Data Sharing And Ontology Use Among Agricultural Genetics, Genomics, And Breeding Databases And Resources Of The Agbiodata Consortium, Jennifer L. Clarke, Laurel D. Cooper, Monica F. Poelchau, Tanya Z. Berardini, Justin Elser, Andrew D. Farmer, Stephen Ficklin, Sunita Kumari, Marie-Angélique Laporte, Rex T. Nelson, Rie Sadohara, Peter Selby, Anne E. Thessen, Brandon Whitehead, Taner Z. Sen

Department of Statistics: Faculty Publications

Over the last couple of decades, there has been a rapid growth in the number and scope of agricultural genetics, genomics and breeding databases and resources. The AgBioData Consortium (https://www.agbiodata.org/) currently represents 44 databases and resources (https://www.agbiodata.org/databases) covering model or crop plant and animal GGB data, ontologies, pathways, genetic variation and breeding platforms (referred to as ‘databases’ throughout). One of the goals of the Consortium is to facilitate FAIR (Findable, Accessible, Interoperable, and Reusable) data management and the integration of datasets which requires data sharing, along with structured vocabularies and/or ontologies. Two AgBioData working groups, focused on Data Sharing and …

A Scoping Review Of Nutrition Health For Older Adults: Does Technology Help?, Dara L. Lobuono, Michael Milovich Jr.

Rita & Larry Salva School of Nursing and Health Professions Departmental Research

The technological developments in healthcare may help facilitate older adult nutritional care. This scoping review includes research in technology and nutrition to (1) explain how technology is used to manage nutrition needs and (2) describe the forms of technology used to manage nutrition. Five major databases were the foundation for papers published from January 2000 to December 2020. The most common type of technology used is software to (1) “track, plan, and execute” nutrition management and for (2) “assessing” technology use. “Track, plan, and execute” includes tracking food intake, planning for changes, and executing a plan. “Assessing” technology use is …

Numeracy, Consistency, And The Allais Paradox, Sean J. Mcginity

Theses and Dissertations

This paper explores the relations between mathematical abilities and preferences, preferences for consistency, and the Allais paradox. To answer this question, 144 participants completed a survey which measured objective numeracy, subjective numeracy, preference for consistency, and consistency of probabilistic choices. The results did not show the predicted relations where consistency would moderate the relations where subjective numeracy mediates the relations between objective numeracy and the consistency of probabilistic choices. The previously indicated relations where subjective numeracy simply mediated the relations between objective numeracy and probabilistic reasoning were also not replicated.While the hypotheses were not supported overall one interesting finding was …