Digital Commons Network^™

Whole Genome Analysis And Molecular Traceability Of Pseudomonas Aeruginosa In Drinking Water, Guo Kun-Peng, Zhang Hai-Yun, He Juan, Gao Han, Yang Tao, Song Sheng

Food and Machinery

Objective: Provide data support for the source tracing and pollution prevention of Pseudomonas aeruginosa in drinking water in Hunan Province. Methods: According to the national food safety standards of GB 8538—2016, the bottled water was tested randomly collected from partial cities and counties in Hunan Province, and the whole genome sequencing and molecular traceability of the 18 strains of Pseudomonas aeruginosa were detected. The carrying of virulence genes and drug resistance genes was detected. Results: It was confirmed that four strains of Pseudomonas aeruginosa showed consistency in terms of geographical distance, genetic distance, pathogenic and drug-resistant genotypes, and it was …

Purification Of Polyphenols From Wormwood By Macroporous Resin And Inhibitory Activity Of Its Against Α-Glucosidase, Wu Ping-Xiang, Wei Ming, Ding Kai-Li, Nie Feng

Food and Machinery

Objective: This study aimed to purify crude polyphenols from wormwood and to study inhibitory activity of its against α-glucosidase. Methods: The adsorption-desorption properties of wormwood polyphenols by seven kinds of macroporous resins were studied. The suitable resin for separating and purifying Wormwood polyphenols was obtained and the purification parameters were optimized. Using different concentration ethanol solution for dynamic elution, the inhibitory activity of different elution fractions on α-glucosidase was investigated. Results: The results indicated that D101 resin was a suitable material for purifying wormwood polyphenols and the macroporous resin reached equilibrium within 120 min. The optimal conditions for …

Modified Quechers Method Combined With Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry For Simultaneous Determination Of 19 Quinolones And Sulfonamides In Aquatic Products, Sun Juan, Yang Jing, Zhao Chun-Hui, Shen Yuan, Li Ying, Fang Fang

Food and Machinery

Objective: A simultaneous determination method was established for detecting 19 kinds of quinolones and sulfonamides in aquatic products simultaneously, by using QuEChERS combined with UPLC-MS/MS. Methods: Samples were extracted with 1.0% formic acid acetonitrile solution, ultrasonic for 1 min, and purified by QuEChERS multi-function needle filter. The sample purification and filtering were performed simultaneously. The Mass spectrometry was conducted by using positive (ESI+) electrospray ionization and multi-reactions monitoring (MRM) models, with external standard method. Results: The detection limit of 19 kinds of sulfonamides and quinolones is from 0.5 to 1.0 μg/kg. Compared with the national standard method, the detection sensitivity …

Determination Of Three Sterols In Camellia Oleifera Seed Oil By Atmospheric Pressure Chemical Ionization Ultra Performance Liquid Chromatography-Time Of Flight Mass Spectrometry, Pan Jin-Hua, Chen Feng, Bai Jian-Ping, Duan Xue-Fei, Li Qi-Qi

Food and Machinery

Objective: In this study, ultra performance liquid chromatography-high resolution quadrupole time of flight mass spectrometer (UPLC-Q-TOF/MS) was established to determine β-sitosterol, brassicasterol, and campesterol in camellia oleifera seed oil. Methods: Using 6-ketocholestanol as the internal standard and performing sample extraction by heating it for 30 min and refluxing it with 50 mL ethanol. After centrifugation and layering, three sterols were separated by Xbridge BEH C₁₈ (100 mm × 4.6 mm, 2.5 μm) Chromatographic column elution. Finally, ionized by atmospheric pressure chemical ionization source and analyzed by positive ion mode. Results: The internal standard curves of the three sterols …

Effects On The Preservation Of Chilled Mutton By Using Polylactic Acid Nanofiber Films Loaded With Perillaldehyde, Wang De-Bao, Zou Yu-Fu, Li Jia, Yao Duo, Li Xing-Yun

Food and Machinery

Objective: The purpose of the study was to investigate the antibacterial mechanical properties of PLA nanofiber film loaded with PAE and its preservation effect on chilled mutton. Methods: By loading different amount (0, 12.5, 25, 50, 100 μL/20 mL) of electrospinning solution perillaldehyde (PAE) in polylactic acid (PLA) matrix, the antibacterial nanofiber film packaging with certain water absorption properties was prepared through electrospinning technology. The appearance and mechanical properties of PAE-PLA packaging film and physical-chemical indexes of mutton during preservation were analyzed via scanning electron microscopy and electronic universal testing machine. Results: With the increase of loading amount of PAE …

Improvement Of Antarctic Krill Oil On Reserpine Induced Zebrafish Depression Model, Guo Meng-Jie, Liu Yun, Wu Zhi-Qiang, Jiang Guo-Liang

Food and Machinery

Objective: This study aimed to investigate the effect of Antarctic krill oil on zebrafish model of depression. Methods: The zebrafish (Danio rerio) model of depression was induced by 40 mg/L reserpine, and five groups, i.e., blank control group, model group, fluoxetine group, low-dose krill oil group and high-dose krill oil group were investigated and compared, buy using new tank test (NTT) and light dark box test (LDB). The central nervous system serotonin (5-HT), dopamine (DA), monoamine oxidase A (MAO-A) Interleukin-6 (IL-6), tumor necrosis factor α (TNF-α) and systemic cortisol (COR) levels of the five groups were …

Changes Of Quality Characteristics And Antioxidant Capacities During Fruit Development Of Hardy Kiwifruit, Zhang Liang-Ying, Liu Lin, Yu Li-Jie, Liu Qi, Qi Bian-Bin

Food and Machinery

Objective: This study aimed to provide theoretical basis for hardy kiwifruit quality improvement and rational utilization. Methods: Taking the main variety 'Longcheng No. 2' and line 'Haijia' as experimental materials, the changes of basic quality indexes, contents of total phenolics and flavonoids were analyzed during fruit development. On this basis, the antioxidant capacities were comprehensively evaluated by three assays (FRAP iron reducing ability, ABTS radical scavenging ability and DPPH radical scavenging ability). Furthermore, the differences of total phenolics and antioxidant capacities in different parts of fruit were compared. Results: ① The contents of soluble solids, titratable acids and Vc in …

Antioxidant And Hypoglycemic Activities Of Different Graded Fractions Of Polysaccharide From Goldenmelon, Chen Bing-Jie, Qiao Yong-Jin, Wang Xiao, Wang Chun-Fang, Liu Gui-Ge

Food and Machinery

Objective: The study aimed to research the physicochemical properties, structure, antioxidant activity and hypoglycemic activity of different fractions of polysaccharide of goldenmelon. Methods: Four kinds of goldenmelon polysaccharides (CP-40, CP-60, CP-70, CP-80) were obtained by graded purification of water extraction and alcoholic precipitation. Their molecular weight, monosaccharide composition, group composition, antioxidant and hypoglycemic activities were investigated by high performance liquid chromatography and fourier transform infrared spectroscopy. Results: With the increase of ethanol volume fraction, the total sugar content increased and the glucuronic acid content decreased. The molecular weights of these four polysaccharides were different, which indicated by the same composition …

Effects Of Different Growth Patterns On Nutritional Quality Of Nostoc Commune, Xie Jie-Fei, Wang Chao, Deng Zhong-Yang

Food and Machinery

Objective: Replacing wild resources with artificially cultivated Nostoc commune to protect the natural environment. Methods: Compare the biochemical composition, texture characteristics, and sensory evaluation of indoor, outdoor cultivation and wild N. commune, while using outdoor cultivation of Nostoc sphaeroides as a control in the above three aspects. Results: The ratio of dry weight to wet weight of wild N. commune was the largest （2.42%）, and its hardness and elasticity were the highest, which were 1.184 N and 78.5%, respectively. The content of phycoerythrin and polysaccharide of outdoor N. commune were the lowest, which were 0.19% and 24.45%, respectively. The …

Study On The Effects Of Adding Konjac Refined Flour On The Quality Of Fresh Wet Rice Noodle, Gong Xue, Xie Song-Feng, Xia Zeng-Run, Wang Ai-Xia, Tong Li-Tao

Food and Machinery

Objective: This study aimed to develop konjac rice noodles products with low glycemic index. Methods: The fresh wet rice noodles was made by adding 20%, 10% and 5% konjac refined flour into rice noodles, respectively. The effects of the addition of konjac refined flour on the texture, cooking performance, and sensory quality of rice noodles were studied by texture analyzer and rapid viscosity analyzer. The starch hydrolysis rate, digestion rate, and glycemic index of konjac rice noodles were studied by in vitro digestion model. Results: The cooking loss rate and turbidity of 5% konjac rice noodles were significantly reduced, and …

Preparation Of Ppi-Ta-Md Microcapsules By Pickering Emulsion Method And Its Effect On Oxidation Stability Of Pumpkin Seed Oil, Zhuang Hu, Yang Xiao-Fan, Liu Xin-Le, Lei Yu-Qing, Li Shu-Gang

Food and Machinery

Objective: This study aimed to improve the oxidation, exploitation, and utilization of pumpkin seed oil (PSO). Methods: Pea protein isolate (PPI) -Tannic acid (TA) stabilized Pickering emulsion with Maltodextrin (MD) was used as the filling material, and prepared pumpkin seed oil microcapsules by spray drying. Results: After spray drying the Pickering emulsion, the smooth surface of the medium shell structure of microcapsule powder can be obtained. By increasing TA concentration, microcapsules showed smaller particle size [(32.00±0.28) μm], lower moisture content [(1.970±0.043)%], and higher bulk density [（0.725±0.014) g/cm³]. The FFA release rate of pumpkin seed oil microcapsules with different …

Effects Of Dynamic High-Pressure Processing On Bioactive Components Of Milk, Ai Zheng-Wen, Xu Zhi-Yuan, Ye Jing-Jin

Food and Machinery

Milk contains a variety of bioactive ingredients, such as lactoferrin and immunoglobulin, which are beneficial to health. Reducing the loss of these proteins during processing has always been the focus of attention. Dynamic high-pressure processing technology, also known as ultra-high-pressure homogenization (UHPH), is one of the relatively novel processing technology means. In this review, the research progress of the heat load intensity and the retention of key nutrients in the processing of dairy products were summarized from the aspects of Maillard reaction products, lactoferrin, immunoglobulin and other bioactive ingredients and vitamin loss. Moreover, the development direction of ultra-high-pressure homogenization in …

Structure, Working Principle And Application Of Mechanical Shell Breaker, He Ting, Zhang Rui, Ren Guang-Yue, Duan Xu, Li Cai-Yun, Li Ya-Chun

Food and Machinery

Shelling rate and kernel breaking rate are the two key indicators of shelled materials, and mechanical shelling is one of the important methods to improve these key indicators. In this paper, the common mechanical shelling methods, mechanical shelling types, mechanical shelling principles and development status of shelling materials were analyzed. The advantages and disadvantages of mechanical hulling equipment were summarized, and suggestions were made for the problems existing in the current application of mechanical hulling.

Research Progress Of Polyphenols In Edible Plant Enzymes, Yin Xiao-Qing, Wen Hua-Ying, Zhang Yu-Hong, Bai Ting, Wang Shan-Shan

Food and Machinery

Polyphenol is one of the characteristic physical and chemical indexes of edible plant enzyme, which has the effects of anti-oxidation, reducing fat and anti-tumor. This paper reviews the composition of polyphenols in food plant enzyme products, the factors affecting the formation of polyphenols in food plant enzyme products, the health care effects of polyphenols, and the further research directions of polyphenols in edible plant enzymes are also prospected.

Advances In Non-Thermal Treatment Techniques To Control Yogurt Post-Acidification, Niu Yu-Qin, Wang Chen-Yuan, Zhao Pei, Li Shu-Sen, Liu Ju-Long, Sun Er-Na, Wu Zi-Jian

Food and Machinery

Post-acidification is one of the most important factors affecting the sensory quality, flavor characteristics and stability of yogurt during shelf-life. Non-thermal treatments are novel methods to control post-acidification, which can maintain the original nutritional properties and sensory quality of food to the maximum extent. In this paper, the mechanism of post-acidification of lactic acid bacteria was reviewed. The mechanism and recent research progress of non-heat treatment processes such as ultra-high pressure, ultrasound, pulsed electric field, CO₂ treatment, irradiation were analyzed and provided theoretical guidance for the development and industrial application of non-heat acid control technology.

Amino Acid Characteristics And Nutritional Evaluation Of Flammulina Filiformis Protoplast Hybrid Strains, Lu Huan, Liu Jianyu, Shang Xiaodong, Yang Hui, Wu Yansha, Wang Ruijuan

Food and Machinery

Objective: This study aimed to investigate the quality differences among different hybrid enoki mushrooms （Flammulina filiformis） strains and breed new strains with high quality. Methods: Two different protoplast monocytes of yellow enoki mushrooms Fv1923 were used as one of the parents to cross with 6 enoki mushrooms protoplasts （2 yellow and 4 white strains）, and a total of 12 yellow hybrid strains were obtained. Principal component analysis and cluster analysis were used to evaluate the free amino acids of 12 hybrid strains, and the flavor diversity of different protoplast hybrid strains was also evaluated. Results: The average contents …

Effects Of Alkali-Heat-Modified Rice Residue Glutenin On Stability Of W/O/W Double Emulsions, Guo Yuanbo, Xue Jing, Zhang Cheng, Wang Zhixiao, Fu Xiangjin, Long Zhao

Food and Machinery

Objective: To achieve the application of rice dreg glutelin in emulsions system. Methods: This paper selected alkali-heat modified rice dregs glutenin and span80 as emulsifiers to prepare W/O/W double emulsions by one-step emulsification method, and investigated the effect of protein concentration on the stability of double emulsions to provide the theoretical reference for the preparation of stable double emulsions by one-step emulsification. Results: When the protein mass fraction increased from 0.5% to 2.5%, the large particle size peak disappears in emulsion, the apparent viscosity and viscoelasticity of emulsions were improved, the centrifugal stability and storage stability were enhanced, enhanced dual …

A Method For On-Site And Rapid Detection Of Trace Cadmium In Rice Based On Colloidal Goldlateral Chromatography, Wang Ranran, Yao Li, Yao Bangben, Chen Wei, Chen Zhaoran

Food and Machinery

Objective： A colloidal gold test strip method that can achieve on-site and rapid detection of cadmium elements in rice was established. Methods： Based on lateral immunochromatographic technology, the colloidal gold test strip was systematically optimized for a series of parameters that affect the detection performance. Results： The visual detection limit of cadmium in rice was reached at 10 ng/g with the colloidal gold test strip. In practical applications, the sample pretreatment process is simple, low concentration acid can be directly extracted and diluted for test strip detection. Conclusion: The colloidal gold test strip was suitable for on-site rapid screening ofcadmium …

Design And Experiment Of Light Angle Adjustable Device For Measuring Sugar Content Of Citrus By Near Infrared Spectroscopy, Zeng Xianming, Han Longbo, Wen Tao, Dai Xingyong

Food and Machinery

Objective: To solve the problem of insufficient spectral information obtained by the fixed illumination angle of the near-infrared spectroscopy to detect the sugar content of fruits. Methods: A light angle adjustable device for the diffuse transmission near-infrared spectroscopy was designed to detect the sugar content of citrus based on the simplified model of the remote motion center of the light source. The device had carried out the structural performance analysis and the test of the citrus sugar under different illumination angles. Results: The adjustment range of the light angle of the device was set to 0°～60°. The displacement deviation between …

The Effect Of Grape Seed Extract Nanoparticles/Pullulan Coatings On The Quality Of Salmon Fillets, Guo Yajuan, Fan Jungang, Li Jianzhen

Food and Machinery

Objective： This study aimed to improve the preservation properties of pullulan （PUL） coating and prepare preservation materials with sustained-release properties. Methods： GSE nanoparticles were prepared by grape seed extract （GSE）, chitosan and γ-polyglutamic acid. GSE nanoparticles of different quality were added to the PUL coating solution to prepare GSE nanoparticles/PUL coatings. The preservation properties of GSE nanoparticles/PUL coatings on salmon fillets were evaluated. Results： Compared with untreated fish fillets, the total number of bacteria in fish meat was reduced, and lipid oxidation and protein decomposition were delayed by 1.08% GSE nanoparticles/PUL coating. In addition, after fish fillets were treated …

Reply To: Beyond Microbial Carbon Use Efficiency, Feng Tao, Johannes Lehmann, Ying-Ping Wang, Lifen Jiang, Bernhard Ahrens, Kostiantyn Viatkin, Stefano Manzoni, Benjamin Z. Houlton, Yuanyuan Huang, Bruce A. Hungate, Serita D. Frey, Michael W. I. Schmidt, Markus Reichstein, Nuno Carvalhais, Philippe Ciais, Umakant Mishra, Gustaf Hugelius, Toby D. Hocking, Xingjie Lu, Zheng Shi, Ronald Vargas, Yusuf Yigini, Christian Omuto, Ashish A. Malik, Guillermo Peralta, Rosa Cuevas-Corona, Luciano E. Di Paolo, Isabel Luotto, Cuijuan Liao, Yi-Shuang Liang, Vinisa S. Saynes, Xiaomeng Huang

Faculty Publications

In their commentary, Xiao et al. cautioned that the conclusions on the critical role of microbial carbon use efficiency (CUE) in global soil organic carbon (SOC) storage in a paper by Tao et al. (2023) might be too simplistic. They claimed that Tao et al.’s study lacked mechanistic consideration of SOC formation and excluded important datasets. Xiao et al. brought up important points, which can be largely reconciled with our findings by understanding the differences in expressing processes in empirical studies and in models.

Transepithelial Electrical Impedance Increase Following Porous Substrate Electroporation Enables Label-Free Delivery, Justin R. Brooks, Tyler C. Heiman, Sawyer R. Lorenzen, Ikhlaas Mungloo, Siamak Mirfendereski, Jae Sung Park, Ruiguo Yang

Department of Mechanical and Materials Engineering: Faculty Publications

Porous substrate electroporation (PSEP) is a promising new method for delivering molecules such as proteins and nucleic acids into cells for biomedical research. Although many applications have been demonstrated, fundamentals of the PSEP delivery process are not yet well understood, partly because most PSEP studies rely solely on fluorescent imaging for evaluating delivery and quantifying successful outcomes. Although effective, only utilizing imaging alone limits our understanding of the intermediate processes leading to intracellular delivery. Since PSEP is an electrical process, electrical impedance measurements are a natural addition to fluorescent imaging for PSEP characterization. In this study, we developed an integrated …

A Brief History Of Kappa Delta Pi, Psi Chapter, Stephen J. Fortgang, Becky W. Hawbaker

Faculty Book Gallery

The Psi Chapter at the Iowa State Teachers College (ISTC) was the twenty-third KDP chapter, installed on August 7th, 1923. Mabel I. Payne, the Secretary/Treasurer of the National KDP organization was in attendance as the installation officer. Eight other chapters were installed that year, and by its 25th anniversary in 1936, KDP had grown to 106 chapters nationally. Early members of the Psi Chapter included the State Teacher’s College President Homer Seerley as an honorary member and Dr. E. O. Finkbender of the Department of Education, who became the chapter counselor.

Six Week Chronic Pain Group's Impact On Relationship To Pain And Mental Health Symptoms, Samuel Sperling, Lcsw

Jefferson Hospital Staff Papers and Presentations

Introduction

A study published in May of 2023 from the National Institutes of Health (NIH) shows that “new cases of chronic pain occur more often among U.S. adults than new cases of several other common conditions, including diabetes, depression, and high blood pressure”.

Given the increasing needs for behavioral health services within the primary care landscape and the workforce shortage, it’s imperative that we consider ways to address the growing gaps in care for patients, especially those suffering with chronic pain.

This six-week group explored the impact of pain interventions (e.g., Pain Reprocessing Therapy, Cognitive Behavioral Therapy, Psychoeducation and Mindfulness) …

Hydrogen Peroxide-Dependent Oxidation Of Erk2 Within Its D-Recruitment Site Alters Its Substrate Selection, Anthony E. Postiglione, Laquaundra L. Adams, Ese S. Ekhator, Anuoluwapo E. Odelade, Supriya Patwardhan, Meenal Chaudhari, Avery S. Pardue, Anjali Kumari, William A. Lefever, Olivia P. Tornow, Tamer S. Kaoud, Johnathan Neiswinger, Jun Seop Jeong, Derek Parsonage, Kimberly J. Nelson, Dukka Kc, Cristina M. Furdui, Heng Zhu, Andrew J. Wommack, Kevin N. Dalby, Ming Dong, Leslie B. Poole, Jeremiah D. Keyes, Robert H. Newman

Michigan Tech Publications

Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are dysregulated in many pervasive diseases. Recently, we discovered that ERK1/2 is oxidized by signal-generated hydrogen peroxide in various cell types. Since the putative sites of oxidation lie within or near ERK1/2’s ligand-binding surfaces, we investigated how oxidation of ERK2 regulates interactions with the model substrates Sub-D and Sub-F. These studies revealed that ERK2 undergoes sulfenylation at C159 on its D-recruitment site surface and that this modification modulates ERK2 activity differentially between substrates. Integrated biochemical, computational, and mutational analyses suggest a plausible mechanism for peroxide-dependent changes in ERK2-substrate interactions. Interestingly, oxidation decreased ERK2’s …

Domoic Acid In Canadian Pacific Waters, From 2016 To 2021, And Relationships With Physical And Chemical Conditions, R. Ian Perry, Nina Nemcek, Melissa Hennekes, Akash Sastri, Andrew R.S. Ross, Hayleigh Shannon, Ryan B. Shartau

Biology Faculty Publications and Presentations

Domoic acid, a phycotoxin produced by species of the marine diatom Pseudo-nitzschia, can cause deleterious impacts to marine food webs and human health. Domoic acid and Pseudo-nitzschia spp. were surveyed from 2016 to 2021 in the Pacific waters of Canada to assess their occurrences, concentrations, and relationships with physical and chemical conditions. Domoic acid was common, occurring in measurable concentrations in 73% of the 454 samples. It occurred in all regions (west coast of Vancouver Island, Salish Sea, Queen Charlotte Sound /Hecate Strait, deep oceanic NE Pacific), in all years and all seasons. Median concentrations were highest along the west …

Early Resveratrol Treatment Mitigates Joint Degeneration And Dampens Pain In A Mouse Model Of Pseudoachondroplasia (Psach), Jacqueline T Hecht, Alka C Veerisetty, Debabrata Patra, Mohammad G Hossain, Frankie Chiu, Claire Mobed, Francis H Gannon, Karen L Posey

2020-Current year OA Pubs

Pseudoachondroplasia (PSACH), a severe dwarfing condition associated with early-onset joint degeneration and lifelong joint pain, is caused by mutations in cartilage oligomeric matrix protein (COMP). The mechanisms underlying the mutant-COMP pathology have been defined using the MT-COMP mouse model of PSACH that has the common D469del mutation. Mutant-COMP protein does not fold properly, and it is retained in the rough endoplasmic reticulum (rER) of chondrocytes rather than being exported to the extracellular matrix (ECM), driving ER stress that stimulates oxidative stress and inflammation, driving a self-perpetuating cycle. CHOP (ER stress signaling protein) and TNFα inflammation drive high levels of mTORC1 …

Transcript: The Future Of Ivf Post Dobbs, Rebecca Feinberg

Journal of Law and Health

The following is a transcription from The Healthcare and Privacy Law Consequences Following Dobbs presented at Cleveland State University College of Law by The Journal of Law & Health on February 17, 2023. This transcript has been lightly edited for clarity and to reflect updates in the relevant law since the time of transcription.

Xaluritamig, A Steap1 × Cd3 Xmab 2+1 Immune Therapy For Metastatic Castration-Resistant Prostate Cancer: Results From Dose Exploration In A First-In-Human Study, William K. Kelly, Daniel C. Danila, Chia-Chi Lin, Jae-Lyun Lee, Nobuaki Matsubara, Patrick J. Ward, Andrew J. Armstrong, David Pook, Miso Kim, Tanya B. Dorff, Stefanie Fischer, Yung-Chang Lin, Lisa G. Horvath, Christopher Sumey, Zhao Yang, Gabor Jurida, Kristen M. Smith, Jamie N. Connarn, Hweixian L. Penny, Julia Stieglmaier, Leonard J. Appleman

Kimmel Cancer Center Faculty Papers

ABSTRACT : Xaluritamig (AMG 509) is a six-transmembrane epithelial antigen of the prostate 1 (STEAP1)-targeted T-cell engager designed to facilitate lysis of STEAP1-expressing cancer cells, such as those in advanced prostate cancer. This first-in-human study reports monotherapy dose exploration for patients with metastatic castration-resistant prostate cancer (mCRPC), primarily taxane pretreated. Ninety-seven patients received ≥1 intravenous dose ranging from 0.001 to 2.0 mg weekly or every 2 weeks. MTD was identified as 1.5 mg i.v. weekly via a 3-step dose. The most common treatment-related adverse events were cytokine release syndrome (CRS; 72%), fatigue (45%), and myalgia (34%). CRS occurred primarily during …

Nutritional Challenges Of Substituting Farmed Animals For Wild Fish In Human Diets, Sebastian A. Heilpern, Rafael M. Almeida, Kathryn J. Fiorella, Alexander S. Flecker, Demetra Williams, Peter B. Mcintyre

School of Earth, Environmental, & Marine Sciences Faculty Publications

Wild fisheries provide billions of people with a key source of multiple essential nutrients. As fisheries plateau or decline, nourishing more people will partially rely on shifting consumption to farmed animals. The environmental implications of transitions among animal-sourced foods have been scrutinized, but their nutritional substitutability remains unclear. We compared concentrations of six essential dietary nutrients across >5000 species of wild fishes, aquaculture, poultry and livestock species, representing >65% of animals consumed globally. Wild fishes are both more nutrient-dense and variable than farmed animals; achieving recommended intake of all nutrients with farmed species could require consuming almost four times more …