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Elucidation Of Molecular Mechanisms Underlying Novel Multi-Targeted Therapy Strategies For, Qianqian Hu

USF Tampa Graduate Theses and Dissertations

EML4-ALK fusion non-small cell lung cancer (NSCLC) represents a distinct subset of lung cancers that possesses unique molecular and clinical features, paving the way for targeted therapeutic interventions. Despite the promise of ALK-directed therapies, challenges such as metastasis at the time of diagnosis and treatment resistance persist, necessitating deeper research into the underlying mechanisms and potential solutions. In the context of these challenges, our study embarked on two specific objectives. The first goal, elucidated in Chapter 2, revolved around brain metastasis, an event critically facilitated by cell migration. Here, we assessed the anti-migratory activities of several clinical ALK inhibitors in …

Ocean Sound Essential Ocean Variable Implementation Plan, Peter Tyack, Akamatsu Tomonari, Olaf Boebel, Lucille Chapuis, Elisabeth Debusschere, Christ De Jong, Christine Erbe, Karen Evans, Jason Gedamke, Tess Gridley, Georgios Haralabus, Reyna Jenkins, Jennifer Miksis-Olds, Hanne Sagen, Frank Thomsen, Karolin Thomisch, Edward Urban

Center for Coastal and Ocean Mapping

This document provides guidance for the addition of acoustic observations to the Global Ocean Observing System (GOOS) through implementation of the Ocean Sound Essential Ocean Variable (EOV). The goal of this Ocean Sound EOV Implementation Plan is to define a baseline of how ocean sound observations are collected, analyzed, managed and reported. The Implementation Plan has been produced by a Committee of the International Quiet Ocean Experiment (IQOE), a project co-sponsored by the Scientific Committee on Oceanic Research (SCOR) and the Partnership for Observation of the Global Ocean (POGO).

Pericentrin Deficiency In Smooth Muscle Cells Augments Atherosclerosis Through Hsf1-Driven Cholesterol Biosynthesis And Perk Activation, Suravi Majumder, Abhijnan Chattopadhyay, Jamie M Wright, Pujun Guan, L Maximilian Buja, Callie S Kwartler, Dianna M Milewicz

Faculty, Staff and Student Publications

Microcephalic osteodysplastic primordial dwarfism type II (MOPDII) is caused by biallelic loss-of-function variants in pericentrin (PCNT), and premature coronary artery disease (CAD) is a complication of the syndrome. Histopathology of coronary arteries from patients with MOPDII who died of CAD in their 20s showed extensive atherosclerosis. Hyperlipidemic mice with smooth muscle cell-specific (SMC-specific) Pcnt deficiency (PcntSMC-/-) exhibited significantly greater atherosclerotic plaque burden compared with similarly treated littermate controls despite similar serum lipid levels. Loss of PCNT in SMCs induced activation of heat shock factor 1 (HSF1) and consequently upregulated the expression and activity of HMG-CoA reductase (HMGCR), the rate-limiting enzyme …

Inflammation In The Tumor-Adjacent Lung As A Predictor Of Clinical Outcome In Lung Adenocarcinoma, Igor Dolgalev, Hua Zhou, Nina Murrell, Hortense Le, Theodore Sakellaropoulos, Nicolas Coudray, Kelsey Zhu, Varshini Vasudevaraja, Anna Yeaton, Chandra Goparaju, Yonghua Li, Imran Sulaiman, Jun-Chieh J Tsay, Peter Meyn, Hussein Mohamed, Iris Sydney, Tomoe Shiomi, Sitharam Ramaswami, Navneet Narula, Ruth Kulicke, Fred P Davis, Nicolas Stransky, Gromoslaw A Smolen, Wei-Yi Cheng, James Cai, Salman Punekar, Vamsidhar Velcheti, Daniel H Sterman, J T Poirier, Ben Neel, Kwok-Kin Wong, Luis Chiriboga, Adriana Heguy, Thales Papagiannakopoulos, Bettina Nadorp, Matija Snuderl, Leopoldo N Segal, Andre L Moreira, Harvey I Pass, Aristotelis Tsirigos

Faculty, Staff and Student Publications

Approximately 30% of early-stage lung adenocarcinoma patients present with disease progression after successful surgical resection. Despite efforts of mapping the genetic landscape, there has been limited success in discovering predictive biomarkers of disease outcomes. Here we performed a systematic multi-omic assessment of 143 tumors and matched tumor-adjacent, histologically-normal lung tissue with long-term patient follow-up. Through histologic, mutational, and transcriptomic profiling of tumor and adjacent-normal tissue, we identified an inflammatory gene signature in tumor-adjacent tissue as the strongest clinical predictor of disease progression. Single-cell transcriptomic analysis demonstrated the progression-associated inflammatory signature was expressed in both immune and non-immune cells, and cell …

Voltage- And Calcium-Gated Membrane Currents Tune The Plateau Potential Properties Of Multiple Neuron Types, Curtis L Neveu, Paul Smolen, Douglas A Baxter, John H Byrne

Faculty, Staff and Student Publications

Many neurons exhibit regular firing that is limited to the duration and intensity of depolarizing stimuli. However, some neurons exhibit all-or-nothing plateau potentials that, once elicited, can lead to prolonged activity that is independent of stimulus intensity or duration. To better understand this diversity of information processing, we compared the voltage-gated and Ca²⁺-gated currents of three identified neurons from hermaphroditic Aplysia californica. Two of these neurons, B51 and B64, generated plateau potentials and a third neuron, B8, exhibited regular firing and was incapable of generating a plateau potential. With the exception of the Ca²⁺-gated potassium …

Documents From The November 8, 2023 Meeting Of The Associated Students Of The University Of Montana (Asum), University Of Montana--Missoula. Associated Students

Senate Meeting Agendas and Minutes, 2007-Present

Agenda and meeting minutes from the May 7, 2014 meeting of the Associated Students of the University of Montana (ASUM). The following resolutions were discussed during the meeting:

SB11-23/24: Resolution Commending KBGA

A Single Cell Genomics Atlas Of The Drosophila Larval Eye Reveals Distinct Photoreceptor Developmental Timelines, Komal Kumar Bollepogu Raja, Kelvin Yeung, Yoon-Kyung Shim, Yumei Li, Rui Chen, Graeme Mardon

Faculty, Staff and Students Publications

The Drosophila eye is a powerful model system to study the dynamics of cell differentiation, cell state transitions, cell maturation, and pattern formation. However, a high-resolution single cell genomics resource that accurately profiles all major cell types of the larval eye disc and their spatiotemporal relationships is lacking. Here, we report transcriptomic and chromatin accessibility data for all known cell types in the developing eye. Photoreceptors appear as strands of cells that represent their dynamic developmental timelines. As photoreceptor subtypes mature, they appear to assume a common transcriptomic profile that is dominated by genes involved in axon function. We identify …

Counts, Incidence Rates, And Trends Of Pediatric Cancer In The United States, 2003–2019, David A Siegel, Jessica B King, Philip J Lupo, Eric B Durbin, Eric Tai, Kathi Mills, Elizabeth Van Dyne, Natasha Buchanan Lunsford, S Jane Henley, Reda J Wilson

Faculty, Staff and Students Publications

BACKGROUND: Cancer is a leading cause of death by disease among children and adolescents in the United States. This study updates cancer incidence rates and trends using the most recent and comprehensive US cancer registry data available.

METHODS: We used data from US Cancer Statistics to evaluate counts, age-adjusted incidence rates, and trends among children and adolescents younger than 20 years of age diagnosed with malignant tumors between 2003 and 2019. We calculated the average annual percent change (APC) and APC using joinpoint regression. Rates and trends were stratified by demographic and geographic characteristics and by cancer type.

RESULTS: With …

Tazemetostat For Tumors Harboring Smarcb1/Smarca4 Or Ezh2 Alterations: Results From Nci-Cog Pediatric Match Apec1621c, Susan N Chi, Joanna S Yi, P Mickey Williams, Sinchita Roy-Chowdhuri, David R Patton, Brent D Coffey, Joel M Reid, Jin Piao, Lauren Saguilig, Todd A Alonzo, Stacey L Berg, Nilsa C Ramirez, Alok Jaju, Joyce C Mhlanga, Elizabeth Fox, Douglas S Hawkins, Margaret M Mooney, Naoko Takebe, James V Tricoli, Katherine A Janeway, Nita L Seibel, D Williams Parsons

Center for Medical Ethics and Health Policy Staff Publications

Background: National Cancer Institute-Children's Oncology Group Pediatric Molecular Analysis for Therapy Choice assigns patients aged 1-21 years with refractory solid tumors, brain tumors, lymphomas, and histiocytic disorders to phase II trials of molecularly targeted therapies based on detection of predefined genetic alterations. Patients whose tumors harbored EZH2 mutations or loss of SMARCB1 or SMARCA4 by immunohistochemistry were treated with EZH2 inhibitor tazemetostat.

Methods: Patients received tazemetostat for 28-day cycles until disease progression or intolerable toxicity (max 26 cycles). The primary endpoint was objective response rate; secondary endpoints included progression-free survival and tolerability of tazemetostat.

Results: Twenty patients (median age = …

Is There Clarity On The Horizon For Peri‐Operative Oxygen Therapy?, D. Martin, A. Cumpstey

Peninsula Medical School

No abstract provided.

Substance Use, Gender Differences, And Peer Influence Among College Students, Mary Hurst

Scholars Week

Abstract

College students all around the country have encounters with peers, in which they are pressured to consume alcohol or other substances. This research project investigates the extent to which gender and social anxiety influence an individual's likelihood to conform to peer pressure in the context of substance use. Conformity to peer pressure and its relationship to substance use is a critical area of study due to its implications for public health, prevention strategies, and gender-specific interventions. We will be assessing the potential of social anxiety and peer pressure influencing binge drinking on college campuses. We expect that (1) peer …

Modelling Basal Area Of Perennial Grasses In Australian Semi-Arid Wooded Grasslands, S. G. Marsden, K. C. Hodgkinson

IGC Proceedings (1977-2023)

In many semi-arid pastoral systems, landscape processes easily become dysfunctional. Shifts to less functional states may be irreversible, and have long-term consequences for pastoral profitability and social viability of rural communities. Typically, shifts to lower functional states involve a decline in perennial grasses (Hodgkinson, 1994). Here we develop a conceptual basis for modelling the basal area of perennial grasses in a semi-arid grassland and validate the model using data from a 10-year grazing study.

The Effect Of Manipulated Conservation Margins In Intensively Grazed Dairy Paddocks On The Biodiversity Of Pteromalidae And Braconidae (Hymenoptera: Parasitica), A. Anderson, G. Purvis, A. Helden, H. Sheridan

IGC Proceedings (1977-2023)

Conserving field margins provides an opportunity to enhance biodiversity in agricultural landscapes. The parasitoid Hymenoptera represent one of the most diverse and biologically specialised of all insect groups and play an important role in insect pest control (LaSalle & Gauld, 1993). The diversity of parasitiods in any habitat is theoretically likely to reflect the diversity of host taxa. The aim of this study was to assess the effects of field margin manipulations on the diversity of parasitoids as a wider indication of effects on general arthropod diversity.

Plant Diversity Patterns Along Altitudinal Gradient In Understory Communities Of Darkesh Region, Bojnord, Iran, A. Arjmandi, H. Ejtehadi, F. Memariani, Mansour Mesdaghi

IGC Proceedings (1977-2023)

The ecotone region of Darkesh with an area of 22,500 hectares is located in the Irano-Turanian xeric-continental bioclimatic zone of Khorassan-Kopet Dagh. To investigate the plant diversity patterns of understory communities along three elevation classes of 1100-1600, 1600-2100, and 2100-2600 m, 187 plots were sampled randomly and abundance and cover of species were recorded using 4-m² plots. Beta diversity and Hill indices were calculated by using R and PAST software. A total of 252 species were recorded including 31 perennial grasses. The most abundant grasses were Poa nemoralis, Poa bulbosa, Bromus sterilis, Brachypodium sylvaticum, and Dactylis glomerata subsp. glomerata …

Using Genetic Diversity In Deep Root Systems Of Perennial Forage Grasses And Rice To Capture Carbon In Tropical Soils, J. Arango, Daniel M. Villegas, R. N. Jauregui, J. A. Cardoso, C. Costa Jr., C. Rebolledo, M. F. Alvarez, M. Selvaraj, L. Rodriguez, M. Mayorga, P. Chavarriaga, A. Notenbaert, M. Quintero, M. Da Silva, Manabu Ishitani, M. Peters, I. Rao, Joe Tohme

IGC Proceedings (1977-2023)

Agricultural soils have the potential not only to be sinks of carbon dioxide (CO₂) but also to mitigate the emissions of this gas to the atmosphere, thus, alleviating global warming. Perennial tropical grasses and rice upland and lowland varieties exhibit a large untapped genetic diversity in their root systems (e.g., deep rooting ability, exudation rates and chemical composition) that, if unlocked, could contribute to increased food production in crop-livestock systems while enhancing soil organic carbon (SOC) in tropical regions. Naturebased solutions that improve crop adaptation and SOC storage in tropical soils could help to remove CO₂ from …

Salt Tolerance Mechanisms In Perennial Fodder Grasses, Edna Antony, B. Aravind, A. Amulya, T. Anushree, P. V. Rakshata, F. H. Savitha, M. B. Doddamani, P. V. Kuligod, Akbar, Vinod Kumar, K. Sridhar, Vijay Kumar Yadav

IGC Proceedings (1977-2023)

Salinity stress is one of the most damaging stresses in crop plants. It reduces the productivity of the soil and makes it unsuitable for crop cultivation. Fodder crops are considered the best alternative in such uncultivable land. Using salinity-affected land for pasture development is the best alternative to utilize such lands. However, the extent of salinity tolerance varies among different grass species. In this study, Pearl millet Napier hybrids (PMN hybrid) and guinea grass varieties were studied for salinity tolerance in artificially created saline soils in the ratio of 13:7:1:2 (NaCl: Na₂SO₄: MgCl: CaSO₄, …

Effect Of Soil Nitrogen And Water Content On The Establishment Of A Lolium Perenne L. And Trifolium Repens L. Pasture, M. F. Alonso, Oscar A. Balocchi, I. Calvache, O. Martínez

IGC Proceedings (1977-2023)

Climate change has decreased rainfall in Southern Chile affecting the productivity of the grasslands that sustain the dairy and beef cattle industries. These grasslands are mainly mixtures of Lolium perenne L. and Trifolium repens L. Thus, we study the response on the establishment of a mixture of these two species to three levels of soil water content and two levels of nitrogen (N) fertilization. The trial was carried out in containers sowed in a complete randomized block´s design. Soil moisture measurements were taken daily. N fertilizations was applied at the establishment and every 60 days. Leaf appearance rate was measured …

The Impact Of Creativity On Alpha Activity, Serena Bruneaux

EKU Libraries Research Award for Undergraduates

No abstract provided.

Impact Of Level Of Use On Plant Vigor And Weight Of Festuca Humilior And Calamagrostis Vicunarum, T. Edson, L. Aguirre, E. R. Flores

IGC Proceedings (1977-2023)

Tussock grasslands of Festuca humilior and Calamagrostis vicunarum cover a significant extension of the central Andes of Peru, constituting a plant association highly appreciated by cattle ranchers. The objective of this research was to estimate the cumulative impact of the level of use of the key grasses Festuca humilior and Calamagrostis vicunarum on plant height, vigor, and weight. This study was conducted in a humid grassland of regular condition located at 4186 masl in the Puna ecoregion. The variables evaluated were: plant height, basal and canopy diameter and plant weight. The experiment lasted two years in which individual plants from …

"Tolkien's Eagles: Aves Ex Machina", Deidre Dawson

Journal of Tolkien Research

Many studies of Tolkien’s Eagles have emphasized their role as a narrative device (the deus ex machina) or spiritual symbol and have focused primarily on their intervention in The Hobbit and The Lord of the Rings. This essay argues for a more comprehensive interpretation, and demonstrates that the Eagles function as essential characters throughout Tolkien’s legendarium, beginning with the earliest stories. The importance of eagles in mythology, folklore and literature is highlighted to show how Tolkien combined his deep knowledge of these subjects with his attention to the biology and anatomy of actual eagles to create his own …

Of Foxes, Dancing Bears, And Wolves, John Rosegrant

Journal of Tolkien Research

When in “On Fairy-stories” Tolkien expressed his Faërian wish to understand the proper speech of animals, he was longing to relate with animals in a way that combined communion with them and respect for their separate natures. But the exuberance with which Tolkien expressed this wish changed over time. His early writings are rampant with talking animals and other forms of human-animal condensation in which the animals nevertheless retain their own agency; later in life he grew uneasy with what he now believed to be unrealistic and un-Catholic formulations. Nevertheless, the Faërian wish was so important to him that he …

The Park Ridge Center Bulletin, 2000, N13, January/February, Advocate Aurora Health

Historical Documents - Combined

The Park Ridge Center, Park Ridge, IL: Issue of "The Park Ridge Center Bulletin", a bi-monthly publication from The Park Ridge Center - An Institute for the Study of Health, Faith, and Ethics, associated with Lutheran General Hospital. This issue has feature articles on genetics and faith, including articles on prenatal testing, stem cell research, and genetic mapping and sequencing.

The Park Ridge Center Bulletin, 2000, N14, March/April, Advocate Aurora Health

Historical Documents - Combined

The Park Ridge Center, Park Ridge, IL: Issue of "The Park Ridge Center Bulletin", a bi-monthly publication from The Park Ridge Center - An Institute for the Study of Health, Faith, and Ethics, associated with Lutheran General Hospital. This issue has feature articles on Judaism and health care. There is also a honor roll for donations from individuals and groups in 1999.

The Park Ridge Center Bulletin, 2000, N16, July/August, Advocate Aurora Health

Historical Documents - Combined

The Park Ridge Center, Park Ridge, IL: Issue of "The Park Ridge Center Bulletin", a bi-monthly publication from The Park Ridge Center - An Institute for the Study of Health, Faith, and Ethics, associated with Lutheran General Hospital. This issue has feature articles on children's rights and health care.

The Park Ridge Center Bulletin, 2001, N19, January/February, Advocate Aurora Health

Historical Documents - Combined

The Park Ridge Center, Park Ridge, IL: Issue of "The Park Ridge Center Bulletin", a bi-monthly publication from The Park Ridge Center - An Institute for the Study of Health, Faith, and Ethics, associated with Lutheran General Hospital. This issue has feature articles on religion and the brain.

The Park Ridge Center Bulletin, 2001, N20, March/April, Advocate Aurora Health

Historical Documents - Combined

The Park Ridge Center, Park Ridge, IL: Issue of "The Park Ridge Center Bulletin", a bi-monthly publication from The Park Ridge Center - An Institute for the Study of Health, Faith, and Ethics, associated with Lutheran General Hospital. This issue has feature articles on humanities and health care. There is also a honor roll for donations from individuals and groups in 2000.

The Park Ridge Center Bulletin, 2001, N24, November/December, Advocate Aurora Health

Historical Documents - Combined

The Park Ridge Center, Park Ridge, IL: Issue of "The Park Ridge Center Bulletin", a bi-monthly publication from The Park Ridge Center - An Institute for the Study of Health, Faith, and Ethics, associated with Lutheran General Hospital. This issue has feature articles about cultural competency and religiously informed practice.

The Seventh-Day Adventist Tradition: Religious Beliefs And Healthcare Decisions, 2002, Edwin R. Dubose, James W. Walters

Historical Documents - Combined

Chicago, IL: Park Ridge Center for the Study of Health, Faith, and Ethics published this handbook on the Seventh-day Adventist tradition as part of a series entitled "Religious Traditions and Healthcare Decisions". Sections include:

• The Individual and the Patient-Caregiver Relationship, p. 3
• Family, Sexuality, and Procreation, p. 3
• Genetics, p. 5
• Organ and Tissue Transplantation, p. 6
• Mental Health, p. 7
• Medical Experimentation and Research, p. 7
• Death and Dying, p. 7
• Special Concerns, p. 9

The Jehovah's Witness Tradition: Religious Beliefs And Healthcare Decisions, 2002, Edwin R. Dubose, M. James Penton

Historical Documents - Combined

Chicago, IL: Park Ridge Center for the Study of Health, Faith, and Ethics published this handbook on the Jehovah's Witness tradition as part of a series entitled "Religious Traditions and Healthcare Decisions". Sections include:

• The Individual and the Patient-Caregiver Relationship, p. 4
• Family, Sexuality, and Procreation, p. 6
• Genetics, p. 7
• Organ and Tissue Transplantation, p. 8
• Mental Health, p. 8
• Medical Experimentation and Research, p. 9
• Death and Dying, p. 9
• Special Concerns, p. 10

The Hindu Tradition: Religious Beliefs And Healthcare Decisions, 2002, Arvind Sharma

Historical Documents - Combined

Chicago, IL: Park Ridge Center for the Study of Health, Faith, and Ethics published this handbook on the Hindu faith as part of a series entitled "Religious Traditions and Healthcare Decisions". Sections include:

• The Individual and the Patient-Caregiver Relationship, p. 5
• Family, Sexuality, and Procreation, p. 6
• Genetics, p. 8
• Organ and Tissue Transplantation, p. 9
• Mental Health, p. 10
• Death and Dying, p. 11
• Special Concerns, p. 13