Digital Commons Network^™

Stuyvesant Owners Inc. V. Frantino

All Decisions

No abstract provided.

Identification Of Exosome Protein Panels As Predictive Biomarkers For Non-Small Cell Lung Cancer, Bin Luo, Zujun Que, Xinyi Lu, Dan Qi, Zhi Qiao, Yun Yang, Fangfang Qian, Yi Jiang, Yan Li, Ronghu Ke, Xiaoyun Shen, Hua Xiao, Hegen Li, Erxi Wu, Jianhui Tian

Children’s Nutrition Research Center Staff Publications

Background: Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related deaths worldwide, primarily due to its propensity for metastasis. Patients diagnosed with localized primary cancer have higher survival rates than those with metastasis. Thus, it is imperative to discover biomarkers for the early detection of NSCLC and the timely prediction of tumor metastasis to improve patient outcomes.

Methods: Here, we utilized an integrated approach to isolate and characterize plasma exosomes from NSCLC patients as well as healthy individuals. We then conducted proteomics analysis and parallel reaction monitoring to identify and validate the top-ranked proteins of plasma exosomes.

Results: …

Financial Stress Factors, Psychological Factors And Self-Management Outcomes In Emerging Adults With Type 1 Diabetes, Julia E. Blanchette

Dissertations

The purpose of this study was to explore the relationship between financial stress factors and psychological factors on self-management outcomes (glycemic control [HbA1c] and diabetes-related quality of life [DQoL]) in emerging adults ages 18-25 with type 1 diabetes (T1D) during the transition from pediatric to adult diabetes care. A descriptive, correlational, cross-sectional study design was employed. Emerging adults enrolled in the T1D Exchange Clinic Registry were recruited via email.

Intouch Week Of November 13, 2023, New York Medical College

InTouch

• Dr. Schwartzman Awarded $2.2 Million NIH Grant
• SOM Student Runs for a Purpose at the New York City Marathon
• Meet the Graduate Student Association E-Board for 2023-2024
• Department of Pediatrics Hosts Leonard Newman, M.D. ’70, Assistant Professor Research Symposium
• Alums Reconnect and Rekindle Memories at Reunion
• Faculty Spotlight: Dr. Rota, Research with "Beating Heart"

Chimes: November 13, 2023, Calvin University

Chimes

Faculty and students say dialogue, educaton about Israel-Hamas war necessary by Ethan Meyers & Savannah Shustack

Beyond the talking stage: Governance review begins implementation by Grace Buller & Ethan Meyers

Calvin posts positive student engagement survey results by Savannah Shustack

Calvin grad and professor publish study on re-entry services in West Michigan by Grace Buller

Calvin's DI and DIII hockey teams: What's the difference? by Dillion Baumchen Grace Buller

Founder of Calvin's chemical engineering concentration reflects on the program's beginnings by Jacob Westra

The Knightly: Interview with Pastor Mary by Lauren Nyong

I'm grateful for press freedom at Calvin by …

Wire Snare Close Loop: A Novel Technique To Retrieve Embolized Devices, Manish Bansal, Gary E Stapleton, Srinath T Gowda, Athar M Qureshi

Faculty, Staff and Students Publications

No abstract provided.

Tumor-Resident Lactobacillus Iners Confer Chemoradiation Resistance Through Lactate-Induced Metabolic Rewiring, Lauren E Colbert, Molly B El Alam, Rui Wang, Tatiana Karpinets, David Lo, Erica J Lynn, Timothy A Harris, Jacob H Elnaggar, Kyoko Yoshida-Court, Katarina Tomasic, Julianna K Bronk, Julie Sammouri, Ananta V Yanamandra, Adilene V Olvera, Lily G Carlin, Travis Sims, Andrea Y Delgado Medrano, Tatiana Cisneros Napravnik, Madison O'Hara, Daniel Lin, Chike O Abana, Hannah X Li, Patricia J Eifel, Anuja Jhingran, Melissa Joyner, Lilie Lin, Lois M Ramondetta, Andrew M Futreal, Kathleen M Schmeler, Geena Mathew, Stephanie Dorta-Estremera, Jianhua Zhang, Xiaogang Wu, Nadim J Ajami, Matthew Wong, Cullen Taniguchi, Joseph F Petrosino, K Jagannadha Sastry, Pablo C Okhuysen, Sara A Martinez, Lin Tan, Iqbal Mahmud, Philip L Lorenzi, Jennifer A Wargo, Ann H Klopp

Faculty, Staff and Student Publications

Tumor microbiota can produce active metabolites that affect cancer and immune cell signaling, metabolism, and proliferation. Here, we explore tumor and gut microbiome features that affect chemoradiation response in patients with cervical cancer using a combined approach of deep microbiome sequencing, targeted bacterial culture, and in vitro assays. We identify that an obligate L-lactate-producing lactic acid bacterium found in tumors, Lactobacillus iners, is associated with decreased survival in patients, induces chemotherapy and radiation resistance in cervical cancer cells, and leads to metabolic rewiring, or alterations in multiple metabolic pathways, in tumors. Genomically similar L-lactate-producing lactic acid bacteria commensal to other …

A Cre-Dependent Massively Parallel Reporter Assay Allows For Cell-Type Specific Assessment Of The Functional Effects Of Non-Coding Elements In Vivo, Tomas Lagunas Jr, Stephen P Plassmeyer, Anthony D Fischer, Ryan Z Friedman, Michael A Rieger, Din Selmanovic, Simona Sarafinovska, Yvette K Sol, Michael J Kasper, Stuart B Fass, Alessandra F Aguilar Lucero, Joon-Yong An, Stephan J Sanders, Barak A Cohen, Joseph D Dougherty

2020-Current year OA Pubs

The function of regulatory elements is highly dependent on the cellular context, and thus for understanding the function of elements associated with psychiatric diseases these would ideally be studied in neurons in a living brain. Massively Parallel Reporter Assays (MPRAs) are molecular genetic tools that enable functional screening of hundreds of predefined sequences in a single experiment. These assays have not yet been adapted to query specific cell types in vivo in a complex tissue like the mouse brain. Here, using a test-case 3'UTR MPRA library with genomic elements containing variants from autism patients, we developed a method to achieve …

Draft Final 2023 Residential Metals Abatement Program (Rmap) Whitehall Borrow Submittal, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Fertility Fraud In The Land Of Lincoln: Why Illinois Must Pass Comprehensive Legislation To Address Donor Fraud In Artificial Insemination, Megan R. Garofalo

DePaul Law Review

No abstract provided.

Brown Anole (Anolis Sagrei) Hoxa5: Insights Into The Divergence Of Hoxa5 Gene Expression And Regulation Across Evolutionarily Divergent Gnathostome Vertebrates, Jennifer A. Lange, Amber L. Rittgers, Adam Davis

Georgia Journal of Science

Hox genes are evolutionarily conserved developmental regulatory genes that function, in part, to pattern the anterior-posterior (AP) axis of organs and organ systems during animal embryonic development. Hoxa5, specifically, is shown to be expressed in the spinal cord, somites, or transient compartments giving rise to the vertebrae and ribs, developing gut, lungs, and limbs of the mouse (Mus musculus). The cis-regulatory elements (CREs), or short DNA sequences, that direct Hoxa5 expression in these embryonic domains have been mapped and functionally tested in the mouse as well. Similar Hoxa5 expression patterns have been observed in chicken ( …

Improving The Environmental And Design Performance Of Building Facades Using “Artificial Intelligence”, Nervana Osama Hanafy

Journal of Engineering Research

The construction sector has changed thanks to the use of artificial intelligence in architectural design. To investigate abstract conceptual concepts and produce an infinite number of design ideas based on mathematically determined criteria, AI offers a wide variety of computational methodologies. An exploratory examination of the development of AI in architectural design is presented in this paper. Since its inception as a tool for functional optimization, Artificial Intelligence has evolved into an unmatched source of design inspiration. The mechanism technology is needed to deliver the best lighting possible, depending on the design requirements. The following steps are taken during the …

The Thermal And Energy Performance Comparison Of Extruded Polystyrene Foam Insulation For An Apartment Building In Different Climate Zones,Egypt, Seham Ali Elmozy, Youssef Elkhayat, Engi Eldarwish

Journal of Engineering Research

The energy sector continually grapples with formidable challenges, particularly in nations characterized by burgeoning populations, where the construction industry faces mounting pressure to curtail energy consumption. Among the influential factors impacting a building's energy usage and environmental building performance, thermal insulation materials stand out prominently. Consequently, this research selected a residential building, situated in diverse climatic conditions, to assess the implications of applying thermal insulation materials to the building's envelope on indoor thermal comfort and energy consumption, both in the current period and in the context of climate changes. Utilizing Design Builder software, an apartment was simulated for three major …

Improving The Environmental And Design Performance Of Building Facades Using “Artificial Intelligence”, Nervana Osama Hanafy

Journal of Engineering Research

The construction sector has changed thanks to the use of artificial intelligence in architectural design. To investigate abstract conceptual concepts and produce an infinite number of design ideas based on mathematically determined criteria, AI offers a wide variety of computational methodologies. An exploratory examination of the development of AI in architectural design is presented in this paper. Since its inception as a tool for functional optimization, Artificial Intelligence has evolved into an unmatched source of design inspiration. The mechanism technology is needed to deliver the best lighting possible, depending on the design requirements. The following steps are taken during the …

The Thermal And Energy Performance Comparison Of Extruded Polystyrene Foam Insulation For An Apartment Building In Different Climate Zones,Egypt, Seham Ali Elmozy, Youssef Elkhayat, Engi Eldarwish

Journal of Engineering Research

The energy sector continually grapples with formidable challenges, particularly in nations characterized by burgeoning populations, where the construction industry faces mounting pressure to curtail energy consumption. Among the influential factors impacting a building's energy usage and environmental building performance, thermal insulation materials stand out prominently. Consequently, this research selected a residential building, situated in diverse climatic conditions, to assess the implications of applying thermal insulation materials to the building's envelope on indoor thermal comfort and energy consumption, both in the current period and in the context of climate changes. Utilizing Design Builder software, an apartment was simulated for three major …

A Parallel Algorithm For Updating A Multi-Objective Shortest Path In Large Dynamic Networks, Arindam Khanda, S. M. Shovan, Sajal K. Das

Computer Science Faculty Research & Creative Works

In dynamic networks, where continuous topological changes are prevalent, it becomes paramount to find and update different graph properties without the computational burden of recalculating from the ground up. However finding or updating a multi-objective shortest path (MOSP) in such a network is challenging, as it involves simultaneously optimizing multiple (conflicting) objectives. In light of this, our paper focuses on shortest path search and proposes parallel algorithms tailored specifically for large incremental graphs. We first present an efficient algorithm that updates the single-objective shortest path (SOSP) whenever a new set of edges are introduced. Leveraging this SOSP update algorithm, we …

Usp38 Exacerbates Atrial Inflammation, Fibrosis, And Susceptibility To Atrial Fibrillation After Myocardial Infarction In Mice, Yang Gong, Tingting Yu, Wei Shuai, Tao Chen, Jingjing Zhang, He Huang

Faculty, Staff and Student Publications

BACKGROUND: Inflammation plays an important role in the pathogenesis of atrial fibrillation (AF) after myocardial infarction (MI). The role of USP38, a member of the ubiquitin-specific protease family, on MI-induced atrial inflammation, fibrosis, and associated AF is unclear.

METHODS: In this study, we surgically constructed a mouse MI model using USP38 cardiac conditional knockout (USP38-CKO) and cardiac-specific overexpression (USP38-TG) mice and applied biochemical, histological, electrophysiological characterization and molecular biology to investigate the effects of USP38 on atrial inflammation, fibrosis, and AF and its mechanisms.

RESULTS: Our results revealed that USP38-CKO attenuates atrial inflammation, thereby ameliorating fibrosis, and abnormal electrophysiologic properties, …

Microplastics In Different Tissues Of A Commonly Consumed Fish, Mohammad Belal Hossain, Farjana Haque Pingki, Md Abdus Samad Azad, As-Ad Ujjaman Nur, Partho Banik, Bilal Ahamad Paray, Takaomi Arai, Jimmy Yu

Faculty, Staff and Student Publications

Microplastics (MPs) ingestion by fish signifies a worldwide threat to human health but limited research has examined their existence within the consumable portions (muscle) of fish. Thus, this study was undertaken to unveil the prevalence, characterization, and contamination extent of MPs across various body tissues, including the muscle of the king mackerel (S. guttatus) from the lower Meghna estuary in Bangladesh-a pioneering investigation in this region. In our analysis, we identified a total of 487 MPs, with an average abundance of 48.7 ± 20.3 MPs/individual. These MPs were distributed across different tissues, with respective concentrations of 0.84 ± …

Single-Cell Analysis Differentiates The Effects Of P53 Mutation And P53 Loss On Cell Compositions Of Oncogenic Kras-Driven Pancreatic Cancer, Xinlei Sun, Daowei Yang, Yang Chen

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignant disease with a dismal prognosis. In the past decades, a plethora of genetically engineered mouse models (GEMMs) with autochthonous pancreatic tumor development have greatly facilitated studies of pancreatic cancer. Commonly used GEMMs of PDAC often harbor the oncogenic KRAS driver mutation (KrasG12D), in combination with either p53 mutation by knock-in strategy (Trp53R172H) or p53 loss by conditional knockout (Trp53cKO) strategy, in pancreatic cell lineages. However, the systematic comparison of the tumor microenvironment between KrasG12D; Trp53R172H (KPmut) mouse models and KrasG12D; Trp53cKO (KPloss) mouse models …

Parker, Heidi, Tegan Bryne

Querying the Past: LGBTQ Maine Oral History Project Collection

Heidi Parker is a 47-year-old lesbian, who uses she/her pronouns. Heidi Parker grew up in the South and Seventh-Day Adventist. One of her favorite parts about living in the South and still one of her favorite things today is the mountains. Heidi Parker has moved to a few places around the United States; including New York, Maine, Georgia, North and South Carolina, and Morrow Beach. Heidi Parker worked as a PE teacher before getting a higher degree in Sports Management. After getting her degree, she moved to New York and worked at Syracuse and then moved to Maine to work …

Three Essays On Disability Claiming And Mental Health, Samsun Naher

Economics ETDs

This dissertation is a collection of three essays that study the interconnection between the Affordable Care Act (ACA) Marketplace plans and disability claiming and the effects of the COVID-19 pandemic on prescription drug utilization for anxiety and depression among Medicaid enrollees. The first essay examines the effects of the COVID-19 pandemic on prescription drug use for anxiety and depression among Medicaid enrollees, using Medicaid State Drug Utilization Data. The findings suggest that the COVID-19 pandemic increased the use of prescription drugs for anxiety and depression relative to prescription drugs use for all conditions, but decreased prescription drugs use for anxiety …

Ecological Change And Livestock Governance In A Peruvian National Park, Kenneth R. Young, Eyner Alata, Rodney Chimner, Randall B. Boone, Gillian Bowser, Laura Bourgeau-Chavez, Beatriz Fuentealba, Jessica Gilbert, Javier A. Ñaupari, Molly H. Polk, Sigrid Resh, Cecilia Turin, Melody Zarria-Samanamud

Michigan Tech Publications

While the grazing of livestock has occurred for millennia in the Andes, current sustainability debates center on concerns with co-managing climate change and pastoralism. These discussions have special resonance in places protected by the state for biodiversity, scenery, and sustainable and traditional land uses, such as those found in protected areas and biosphere reserves. For this article, we integrate data from a social-ecological research project on the land use systems that affect high-elevation ecosystems in Peru’s Huascarán National Park, with special emphasis on the wetlands. We used land cover and land use data and insights from interactions with pastoralists to …

Fim111.2 Screen Studies & Practice Example 1, Sae University College

Exemplars

FIM111 Screen Studies and Practice project 2 part 2 (group) examplar - expository documentary

Targeting The Αvβ3/Ngr2 Pathway In Neuroendocrine Prostate Cancer, Anna Testa, Fabio Quaglia, Nicole M. Naranjo, Cecilia E. Verrillo, Christopher D. Shields, Stephen Lin, Maxwell W. Pickles, Drini F. Hamza, Tami Von Schalscha, David A. Cheresh, Benjamin E Leiby, Qin Liu, Jianyi Ding, William K. Kelly, D. Craig Hooper, Eva Corey, Edward F. Plow, Dario C. Altieri, Lucia R. Languino

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Highly aggressive, metastatic, neuroendocrine prostate cancer, which typically develops from prostate cancer cells acquiring resistance to androgen deprivation therapy, is associated with limited treatment options and hence poor prognosis. We have previously demonstrated that the αVβ3 integrin is over-expressed in neuroendocrine prostate cancer. We now show that LM609, a monoclonal antibody that specifically targets the human αVβ3 integrin, hinders the growth of neuroendocrine prostate cancer patient-derived xenografts in vivo. Our group has recently identified a novel αVβ3 integrin binding partner, NgR2, responsible for regulating the expression of neuroendocrine markers and for inducing neuroendocrine differentiation in prostate cancer cells. Through in …

Mothers’ Prenatal Distress Accelerates Adrenal Pubertal Development In Daughters, Molly M. Fox, Jennifer Hahn-Holbrook, Curt A. Sandman, Jessica A. Marino, Laura M. Glynn, Elysia Poggi Davis

Psychology Faculty Articles and Research

Human life history schedules vary, partly, because of adaptive, plastic responses to early-life conditions. Little is known about how prenatal conditions relate to puberty timing. We hypothesized that fetal exposure to adversity may induce an adaptive response in offspring maturational tempo. In a longitudinal study of 253 mother-child dyads followed for 15 years, we investigated if fetal exposure to maternal psychological distress related to children’s adrenarche and gonadarche schedules, assessed by maternal and child report and by dehydroepiandrosterone sulfate (DHEA-S), testosterone, and estradiol levels. We found fetal exposure to elevated maternal prenatal psychological distress predicted earlier adrenarche and higher DHEA-S …

The Importance Of A Healthy Microbiome In Pregnancy And Infancy And Microbiota Treatment To Reverse Dysbiosis For Improved Health, Herbert L Dupont, Madeleine Mary Hines Salge

Faculty, Staff and Student Publications

BACKGROUND: The microbiome of newborn infants during the first 1000 days, influenced early on by their mothers' microbiome health, mode of delivery and breast feeding, orchestrates the education and programming of the infant's immune system and determines in large part the general health of the infant for years.

METHODS: PubMed was reviewed for maternal infant microbiome health and microbiota therapy in this setting with prebiotics, probiotics, vaginal seeding and fecal microbiota transplantation (FMT).

RESULTS: A healthy nonobese mother, vaginal delivery and strict breast feeding contribute to microbiome health in a newborn and young infant. With reduced microbiome diversity (dysbiosis) during …

An Overview Of The Immune Modulatory Properties Of Long Non-Coding Rnas And Their Potential Use As Therapeutic Targets In Cancer, Moises Martinez-Castillo, Abdelrahman M Elsayed, Gabriel López-Berestein, Paola Amero, Cristian Rodríguez-Aguayo

Faculty, Staff and Student Publications

Long non-coding RNAs (lncRNAs) play pivotal roles in regulating immune responses, immune cell differentiation, activation, and inflammatory processes. In cancer, they are gaining prominence as potential therapeutic targets due to their ability to regulate immune checkpoint molecules and immune-related factors, suggesting avenues for bolstering anti-tumor immune responses. Here, we explore the mechanistic insights into lncRNA-mediated immune modulation, highlighting their impact on immunity. Additionally, we discuss their potential to enhance cancer immunotherapy, augmenting the effectiveness of immune checkpoint inhibitors and adoptive T cell therapies. LncRNAs as therapeutic targets hold the promise of revolutionizing cancer treatments, inspiring further research in this field …

Increase In Hnrnpa1 Expression Suffices To Kill Motor Neurons In Transgenic Rats, Xionghao Liu, Tingting Zhang, Qinxue Wu, Cao Huang, Xu-Gang Xia, Hongxia Zhou, Bo Huang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

A dominant mutation in hnRNPA1 causes amyotrophic lateral sclerosis (ALS), but it is not known whether this mutation leads to motor neuron death through increased or decreased function. To elucidate the relationship between pathogenic hnRNPA1 mutation and its native function, we created novel transgenic rats that overexpressed wildtype rat hnRNPA1 exclusively in motor neurons. This targeted expression of wildtype hnRNPA1 caused severe motor neuron loss and subsequent denervation muscle atrophy in transgenic rats that recapitulated the characteristics of ALS. These findings demonstrate that the augmentation of hnRNPA1 expression suffices to trigger motor neuron degeneration and the manifestation of ALS-like phenotypes. …

Considering Green Corridors In Road Networks: An Integrated Gray-Green Approach For Urban Development In Cairo, Egypt., Eman H Ayad, Sarah E. Abdel Rasheed

Journal of Engineering Research

Green corridors are one of the main features for sustainability, they refer to ecological qualities and are basic elements for resilient cities. Many global cities are oriented towards green construction to protect their environments from rapid urbanization and its destructive impact on nature. However, in other cities, this is extremely challenging. In Cairo, contemporary developments are directed towards constructing the ‘Gray’ road networks, whereas the ‘Green’ is nearly disappearing. This study introduces an integrated ‘Gray-Green’ approach for urban development in Cairo, where green corridors are considered to achieve a livable sustainable urban environment. First, the study discusses characteristics, benefits and …

Bringing Biophilic Architecture Into Business Parks Design Towards Enhancing Users Experience, Sara Atwa, Ahmed Khader

Journal of Engineering Research

Recently, most people have spent much of their time at work, often in indoor office buildings that are designed without regard to natural elements and workers` well-being. For these reasons, Business Parks are designed to improve the whole workplace environment. Bringing fresh air, green areas, and natural elements into workspaces could enhance the work environment and increase productivity by taking care of workers` physiological needs. On other hand, Biophilic design introduces some principles to create visually beautiful and spiritual places. By merging Architecture with nature and bringing outdoors greenery through indoor areas, a healthy workplace environment could be generated. Therefore, …