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Determination The Effect Of Glucose On Btp, Lfabp Levels In The Patients With Diabetic Nephropathy, Zahraa Khalid Mahmood, Suhayr Aesa Al-Qaysi, Alaa Jafear Mahrath

Al-Esraa University College Journal for Medical Sciences

Everywhere in the globe, kidney illness is becoming more common, and there is no medication that can stop the progression of chronic kidney disease to end-stage renal disease, which is extremely expensive. Diabetes, kidney stones, accidents, and bleeding are the main contributors to kidney disease. The study was designed as a case control study. The study was involved (80) participants, only (36) were involved in this study and divided into two groups patients with nephropathy (23) and diabetic nephropathy (13) with age (20-65years) and BMI (19 -29 kg/m2). All these patients were diagnosed by nephrologist conducted in nephrology Clinic at …

Genetic Polymorphisms Of Aqp1 Rs10244884 Associated With Iron Deficiency Anemia In Baghdad City, Sawsan Hashim Hoshe, Moead E. Al Gazally, Hussein Naji Al-Shammari

Al-Esraa University College Journal for Medical Sciences

Most people throughout the world suffer from iron deficiency anemia (IDA). The morbidity rate is relatively high for such a complicated illness. Importantly, it has been identified that the aquaporin-1 polymorphism rs10244884 plays a critical role in iron homeostasis in the human body. The rs10244884 (T > C) polymorphism is significantly associated with iron levels and a variety of blood factors, leading to iron deficiency anemia (IDA). Venous blood samples were collected from (100) people in this analytical (case and control) investigation, including (50) patients with iron deficiency anemia and (50) healthy volunteers as a control group. The following parameters were …

Risk Detection Of Gestational Diabetes In Early Pregnancy Depend On Artificial Neural Network, Sanaa Hammad Dhahi

Al-Esraa University College Journal for Engineering Sciences

Early prediction of gestational diabetes mellitus (GDM) risk is particularly important because it may enable more effective interventions and reduce cumulative maternal and fetal injury. The aim of this study is to develop machine learning (ML) models for early prediction of GDM using widely available variables, facilitating early intervention, and enabling the application of prediction models in settings where more complex tests are not accessible. In this paper, an artificial neural network (ANN) was used to detect the risk of gestational diabetes. A global dataset was used to collect clinical and experimental data from pregnant women and people with diabetes …

Abnormal Patterns Of Sleep And Waking Behaviors Are Accompanied By Neocortical Oscillation Disturbances In An Ank3 Mouse Model Of Epilepsy-Bipolar Disorder Comorbidity, Juan E Villacres, Nicholas Riveira, Sohmee Kim, Laura L Colgin, Jeffrey L Noebels, Angel Y Lopez

Faculty, Staff and Students Publications

ANK3 is a leading bipolar disorder (BD) candidate gene in humans and provides a unique opportunity for studying epilepsy-BD comorbidity. Previous studies showed that deletion of Ank3-1b, a BD-associated variant of Ank3 in mice leads to increased firing threshold and diminished action potential dynamic range of parvalbumin (PV) interneurons and absence epilepsy, thus providing a biological mechanism linking epilepsy and BD. To explore the behavioral overlap of these disorders, we characterized behavioral patterns of Ank3-1b KO mice during overnight home-cage activity and examined network activity during these behaviors using paired video and EEG recordings. Since PV interneurons contribute to the …

Analysis Of Drug Diffusion In Human Connective Tissue In Neutrosophic Environment, Supriya Mukherjee, Ashish Acharya, Animesh Mahata, Subrata Paul, Said Broumi, Banamali Roy

Neutrosophic Sets and Systems

No abstract provided.

Multi-Attribute Group Decision-Making Based On Aggregation Operator And Score Function Of Bipolar Neutrosophic Hypersoft Environment, Faisal Al-Sharqi, Ashraf Al-Quran, Zahari Md. Rodzi

Neutrosophic Sets and Systems

No abstract provided.

Waste To Energy Treatment For India Using Critic-Waspas Method Under Interval-Valued Pythagorean Neutrosophic Fuzzy Set, R.Narmada Devi, S. Sowmiya, R. Sundareswaran, Said Broumi

Neutrosophic Sets and Systems

No abstract provided.

The Concise Guide To Pharmacology 2023/24: Catalytic Receptors, Stephen P.H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Annie Beuve, Peter Brouckaert, Clare Bryant, John C. Burnett, Richard W. Farndale, Andreas Friebe, John Garthwaite, Adrian J. Hobbs, Gavin E. Jarvis, Doris Koesling, Michaela Kuhn, David Macewan, Tom P. Monie, Lincoln R. Potter, Michael Russwurm, Harald H.H.W. Schmidt, Johannes-Peter Stasch, Scott A. Waldman

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and nearly 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It …

The Potential For Development Of Clinically Relevant Microbial Resistance To Rifaximin-Α: A Narrative Review, Herbert L Dupont

Faculty, Staff and Student Publications

Rifaximin-α is a gut-targeted antibiotic indicated for numerous gastrointestinal and liver diseases. Its multifaceted mechanism of action goes beyond direct antimicrobial effects, including alterations in bacterial virulence, cytoprotective effects on host epithelial cells, improvement of impaired intestinal permeability, and reduction of proinflammatory cytokine expression via activation of the pregnane X receptor. Rifaximin-α is virtually non-absorbed, with low systemic drug levels contributing to its excellent safety profile. While there are high concentrations of drug in the colon, low water solubility leads to low colonic drug bioavailability, protecting the gut microbiome. Rifaximin-α appears to be more active in the bile-rich small bowel. …

Innovation And Practice On Biodiversity Conservation In Sanjiangyuan National Park, Xinquan Zhao, Shixiao Xu, Liang Zhao, Tongzuo Zhang, Linyong Hu, Qi Li, Tongqing Guo

Bulletin of Chinese Academy of Sciences (Chinese Version)

Sanjiangyuan National Park, is one of the first batch of national parks in China, and serves as the largest national park in China. As an important ecological security barrier and a alpine biological germplasm resource base, it has significant conservation value in China and even in the world. Lots of protocols have been taken aiming at ecological tacking protection issues including loss of biodiversity and wildlife habitats, degradation of alpine grassland and overgrazing in Sanjiangyuan National Park. It promotes the implementation of major ecological restoration projects, and has formed the Sanjiangyuan National Park Biodiversity Conservation and Ecological Protection Program with …

Conception On Asian Elephant Ecological Corridor Planning With Implications For Conservation, Xueyou Li, Qiupeng Yu, Zhechang Hu, Xuelong Jiang

Bulletin of Chinese Academy of Sciences (Chinese Version)

In order to practice the concept of coordinated development of “Lucid Waters and Lush Mountains are Invaluable Assets” and “mountains, rivers, forests, farmlands, lakes, grasslands and deserts are part of the community of life”, this study takes “pursuing green development and promoting harmony between humanity and nature” proposed in the report of the 20th National Congress of the Communist Party of China as the theoretical guidance. With the goal of enhancing ecosystem integrity and connectivity, enhancing population communication, enhancing population viability, and providing a model for the construction of ecological corridors for flagship species, based on the current distribution and …

Atmospheric 14Co2 Observation: A Novel Method To Evaluate Carbon Emissions, Zhenchuan Niu, Peng Wang, Shugang Wu, Weijian Zhou

Bulletin of Chinese Academy of Sciences (Chinese Version)

As an important carbon emitter, China faces the stress of carbon peaking and carbon neutrality goals and international carbon reduction duty. The accurate data of carbon emissions are important to evaluate the carbon peaking and carbon neutrality goals and fulfill the international duty of carbon reduction. The Intergovernmental Panel on Climate Change (IPCC) report recommends the combination of top-down atmospheric CO₂ observation with atmospheric inversion to verify the bottom-up inventory of carbon emissions, and the atmospheric ¹⁴CO₂ observation can make the verification more accurate. Radiocarbon (14C) is the most precise tracer of fossil fuel CO₂ and …

Impacts, Contributing Factors And Countermeasures Of Extreme Droughts In Poyang Lake, Qi Zhang, Chenyang Xue, Jun Xia

Bulletin of Chinese Academy of Sciences (Chinese Version)

In the past 20 years, the hydrological regime of Poyang Lake changed significantly. The lake water level has been continuously decreasing, resulting in severe droughts. In particular, an extreme drought occurred in 2022, when the lake area shrank to less than 300 km2. The 2022 extreme drought in Poyang Lake had great impacts on economy, society and ecological environment, which aroused great attentions and wide concerns. Based on long-term data series of meteorological and hydrological data and the existing research outcomes and with the aid of hydrological modeling, this study analyzed the impacts and contributing factors of the 2022 drought …

Control Of Invasive Plant Spartina Alterniflora: Concept, Technology And Practice, Baohua Xie, Guangxuan Han

Bulletin of Chinese Academy of Sciences (Chinese Version)

Alien Species Spartina alterniflora occupy the living space of native animals and plants, and lead to the reduction of biodiversity in the intertidal zone and wetland ecological service functions. Therefore, it is urgent to curb the rapid expansion of S. alterniflora in China’s coastal areas. This paper introduced the invasion situation and main ecological hazards of S. alterniflora in China, as well as put forward the concept of S. alterniflora control of “hazard assessment – zoning control – monitoring and early warning”. We summarized the control technologies of S. alterniflora at home and abroad and the current situation of S. …

Stereotactic Mr-Guided On-Table Adaptive Radiation Therapy (Smart) For Borderline Resectable And Locally Advanced Pancreatic Cancer: A Multi-Center, Open-Label Phase 2 Study, Michael Chuong, Percy Lee, Daniel Low, Joshua Kim, Kathryn Mittauer, Michael Bassetti, Carri Glide-Hurst, Ann Raldow, Yingli Yang, Lorraine Portelance, Kyle Padgett, Bassem Zaki, Rongxiao Zhang, Hyun Kim, Lauren Henke, Alex Price, Joseph Mancias, Christopher Williams, John Ng, Ryan Pennell, M Raphael Pfeffer, Daphne Levin, Adam Mueller, Karen Mooney, Patrick Kelly, Amish Shah, Luca Boldrini, Lorenzo Placidi, Martin Fuss, Parag Jitendra Parikh

Department of Radiation Oncology Faculty Papers

BACKGROUND AND PURPOSE: Radiation dose escalation may improve local control (LC) and overall survival (OS) in select pancreatic ductal adenocarcinoma (PDAC) patients. We prospectively evaluated the safety and efficacy of ablative stereotactic magnetic resonance (MR)-guided adaptive radiation therapy (SMART) for borderline resectable (BRPC) and locally advanced pancreas cancer (LAPC). The primary endpoint of acute grade ≥ 3 gastrointestinal (GI) toxicity definitely related to SMART was previously published with median follow-up (FU) 8.8 months from SMART. We now present more mature outcomes including OS and late toxicity.

MATERIALS AND METHODS: This prospective, multi-center, single-arm open-label phase 2 trial (NCT03621644) enrolled 136 …

Research Priorities For Children’S Cancer: A James Lind Alliance Priority Setting Partnership In The Uk, Susie Aldiss, Rachel Hollis, Bob Phillips, Ashley Ball-Gamble, Alex Brownsdon, Julia Chisholm, Scott Crowther, Rachel Dommett, Jonathan Gower, Nigel J Hall, Helen Hartley, Jenni Hatton, Louise Henry, Loveday Langton, Kirsty Maddock, Sonia Malik, Keeley Mcevoy, Jessica Elizabeth Morgan, Helen Morris, Simon Parke, Sue Picton, Rosa Reed-Berendt, Dan Saunders, Andy Stewart, Wendy Tarplee-Morris, Amy Walsh, Anna Watkins, David Weller, Faith Gibson

Faculty, Staff and Student Publications

OBJECTIVES: To engage children who have experienced cancer, childhood cancer survivors, their families and professionals to systematically identify and prioritise research questions about childhood cancer to inform the future research agenda.

DESIGN: James Lind Alliance Priority Setting Partnership.

SETTING: UK health service and community.

METHODS: A steering group oversaw the initiative. Potential research questions were collected in an online survey, then checked to ensure they were unanswered. Shortlisting via a second online survey identified the highest priority questions. A parallel process with children was undertaken. A final consensus workshop was held to determine the Top 10 priorities.

PARTICIPANTS: Children and …

Exploring The Relationships Between Psychological Variables And Loot Box Engagement, Part 1: Pre-Registered Hypotheses, James Close, Stuart Gordon Spicer, Laura Louise Nicklin, Maria Uther, Ben Whalley, Chris Fullwood, Jonathan Parke, J Lloyd, H Lloyd

Peninsula Medical School

Loot boxes are purchasable randomized rewards in video games that share structural and psychological similarities with gambling. Systematic review evidence has established reproducible associations between loot box purchasing and both problem gambling and problem video gaming, perhaps driven by a range of overlapping psychological processes (e.g. impulsivity, gambling-related cognitions, etc.) It has also been argued that loot box engagement may have negative influences on player financial and psychological wellbeing. We conducted a pre-registered survey of 1495 loot box purchasing gamers (LB cohort) and 1223 gamers who purchase other, non-randomized game content (nLB cohort). Our survey confirms 15 of our 23 …

Bacterial Outer Membrane Vesicles Provide An Alternative Pathway For Trafficking Of Escherichia Coli O157 Type Iii Secreted Effectors To Epithelial Cells, Natalie Sirisaengtaksin, Eloise J O'Donoghue, Sara Jabbari, Andrew J Roe, Anne Marie Krachler

Faculty, Staff and Student Publications

Outer membrane vesicles (OMVs) are proteoliposomes shed by Gram-negative bacteria. Their secretion is enhanced by the transition into the intra-host milieu, and OMVs play critical roles during pathogenesis. Enterohemorrhagic Escherichia coli O157 (EHEC) can cause diarrheal disease in humans, and soluble toxins including Shiga-like toxins that contribute to disease severity and clinical complications like hemolytic uremic syndrome have been shown to be OMV associated. In addition to Shiga-like toxins, EHEC produces a type III secretion system (T3SS), and T3SS effectors are associated with colonization and disease severity in vivo. Here, we show that type III secreted substrates including translocators …

Colonization Of Larval Zebrafish (Danio Rerio) With Adherent-Invasive Escherichia Coli Prevents Recovery Of The Intestinal Mucosa From Drug-Induced Enterocolitis, Erika Flores, Soumita Dutta, Rachel Bosserman, Ambro Van Hoof, Anne-Marie Krachler

Faculty, Staff and Student Publications

Although inflammatory bowel diseases are on the rise, what factors influence IBD risk and severity, and the underlying mechanisms remain to be fully understood. Although host genetics, microbiome, and environmental factors have all been shown to correlate with the development of IBD, cause and effect are difficult to disentangle in this context. For example, AIEC is a known pathobiont found in IBD patients, but it remains unclear if gut inflammation during IBD facilitates colonization with AIEC, or if AIEC colonization makes the host more susceptible to pro-inflammatory stimuli. It is critical to understand the mechanisms that contribute to AIEC infections …

Storage Protein Activator Controls Grain Protein Accumulation In Bread Wheat In A Nitrogen Dependent Manner, Anne Plessis, Catherine Ravel, Thierry Risacher, Nathalie Duchateau, Mireille Dardevet, Marielle Merlino, François Torney, Pierre Martre

School of Biological and Marine Sciences

The expression of cereal grain storage protein (GSP) genes is controlled by a complex network of transcription factors (TFs). Storage protein activator (SPA) is a major TF acting in this network but its specific function in wheat (Triticum aestivum L.) remains to be determined. Here we generated an RNAi line in which expression of the three SPA homoeologs was reduced. In this line and its null segregant we analyzed GSP accumulation and expression of GSP and regulatory TF genes under two regimes of nitrogen availability. We show that down regulation of SPA decreases grain protein concentration at maturity under low …

Tfeb Degradation Is Regulated By An Ikk/Β-Trcp2 Phosphorylation-Ubiquitination Cascade, Yan Xiong

Arts & Sciences Graduate Student Theses and Dissertations

Transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and autophagy that plays a key role in the regulation of cellular clearance pathways. TFEB is regulated via a complex array of post-translational modifications (PTMs), but the exact molecular mechanism that regulates TFEB stability has remained elusive. Here, we show that TFEB levels are critically regulated by a defined phosphorylation-ubiquitination cascade. A human kinome screen identifies IKK (inhibitor of κB kinase) as a TFEB modifier, and a combination of phosphorylation assays, mass spectrometry analyses, and site-specific mutagenesis unveils a previously unrecognized TFEB phospho-degron (423SPFPSLS429) as the target of IKK. …

A Dynamic Duo: Investigating The Interactions Between Xanthomonas Citri Pv. Malvacearum And Pseudomonas Syringae, Taylor Harris

Arts & Sciences Graduate Student Theses and Dissertations

Bacterial pathogens threaten crop production worldwide, which highlights the need to understand plant and pathogen interactions. Studies on plant-pathogen interactions typically focus on a single host and pathogen. However, bacteria exist in complex microbial communities, not alone. There are few studies that examine the mechanisms behind multi-pathogen infections which renders a gap in our understanding of the subsequent implications on agriculture. In this dissertation, I use in vitro plate assays with RNA-sequencing and in planta assays to investigate the interactions between two cotton bacterial pathogens, Xanthomonas citri pv. malvaearum (Xcm) and Pseudomonas syringae (Ps). In vitro plate assays demonstrate that …

The Faculty-To-Faculty Mentorship Experience: A Survey On Challenges And Recommendations For Improvements, Sarvenaz Sarabipour, Natalie M Niemi, Steven J Burgess, Christopher T Smith, Alexandre W Bisson Filho, Ahmed Ibrahim, Kelly Clark

2020-Current year OA Pubs

Faculty at research institutions play a central role in advancing knowledge and careers, as well as promoting the well-being of students and colleagues in research environments. Mentorship from experienced peers has been touted as critical for enabling these myriad roles to allow faculty development, career progression, and satisfaction. However, there is little information available on who supports faculty and best ways to structure a faculty mentorship programme for early- and mid-career academics. In the interest of advocating for increased and enhanced faculty mentoring and mentoring programmes, we surveyed faculty around the world to gather data on whether and how they …

Observation Of A Calling Assemblage In The Collared Trogon (Trogon Collaris)., Cristina Sainz-Borgo

Ornitología Neotropical

No abstract provided.

Book Reviews–Reseñas De Libros–Resenhas De Livros., Ornitología Neotropical

Ornitología Neotropical

No abstract provided.

Index To Volume 25, 2014. Reviewers For Ornitología Neotropical, Volume 25., Ornitología Neotropical

Ornitología Neotropical

No abstract provided.

Nesting Of The Short-Tailed Antthrush (Chamaeza Campanisona) In The Atlantic Forest Of Argentina., Alejandro Bodrati, Kristina L. Cockle, Facundo G. Di Sallo

Ornitología Neotropical

No abstract provided.

Effects Of Terra Firme-Forest Structure On Habitat Use By Owls (Aves: Strigiformes) In Central Brazilian Amazonia., Priscilla Esclarski, Renato Cintra

Ornitología Neotropical

No abstract provided.

Asymmetric Response To Heterospecific Songs In Two Sympatric Wrens (Troglodytidae) In Argentina: House Wren (Troglodytes Aedon) And Mountain Wren (T. Solstitialis)., Paul R. Martin, Robert C. Dobbs

Ornitología Neotropical

No abstract provided.

Nesting Biology Of The Flame-Faced Tanager (Tangara Parzudakii) In Northeastern Ecuador., Kimberly S. Sheldon, Harold F. Greeney, Robert C. Dobbs

Ornitología Neotropical

No abstract provided.