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Reaching New Heights: 2022-23 Report Of The President, Office Of The President, Gonzaga University

Office of the President Publications

Each year, Gonzaga University's Office of the President produces an annual Report of the President. This publication that highlights just a few of the many accomplishments over the previous academic year, and is intended to convey gratitude to our Trustees and Regents, benefactors, and many supporters.

Gay Emancipation: The Effort To Delete Paragraph 175, Luke Goodwin

Vulcan Historical Review

pp. 8-21

Inquiro 11 (Front Matter), Inquiro Staff

Inquiro (undergraduate research journal)

pp. -6

Letter from the editors: https://www.uab.edu/inquiro/issues/past-issues/volume-11/letter-from-the-editors

Algal Symbionts Of The Freshwater Sponge Ephydatia Muelleri, Katelyn Hustus, Cristina Díez-Vives, Konstantina Mitsi, Jasmine Nutakki, Victor Kering, Ivy T. Nguyen, Mayra Gomes Spencer, Sally P. Leys, Malcolm Hill, Ana Riesgo, April Hill

All Faculty Scholarship

The freshwater sponge, Ephydatia muelleri, is an emerging model system for studying animal:microbe symbioses. Intracellular green microalgae are one of the more common symbionts that live in a facultative mutualism with E. muelleri. While these symbioses have long been known, the identity of the algal symbionts in E. muelleri cells has not been studied in detail. Here, we isolate and characterize endosymbiotic algae from E. muelleri collected from different geographic locations. We find that the algae can be transmitted through asexually produced gemmules and importantly that they can form symbioses with different, differentiated sponge cell types in the adult sponge. …

The Effect Of Climate Change On Avian Offspring Production: A Global Meta-Analysis, Lucyna Halupka, Debora Arlt, Jere Tolvanen, Alexandre Millon, Pierre Bize, Peter Adamík, Pascal Albert, Wayne J. Arendt, Alexander V. Artemyev, Vittorio Baglione, Jerzy Bańbura, Mirosława Bańbura, Emilio Barba, Robert T. Barrett, Peter H. Becker, Eugen Belskii, Mark Bolton, E. Keith Bowers, Joël Bried, Lyanne Brouwer, Monika Bukacińska, Dariusz Bukaciński, Lesley Bulluck, Kate F. Carstens, Inês Catry, Motti Charter, Anna Chernomorets, Rita Covas, Monika Czuchra, Donald Dearborn, Florentino De Lope

All Faculty Scholarship

Climate change affects timing of reproduction in many bird species, but few studies have investigated its influence on annual reproductive output. Here, we assess changes in the annual production of young by female breeders in 201 populations of 104 bird species (N = 745,962 clutches) covering all continents between 1970 and 2019. Overall, average offspring production has declined in recent decades, but considerable differences were found among species and populations. A total of 56.7% of populations showed a declining trend in offspring production (significant in 17.4%), whereas 43.3% exhibited an increase (significant in 10.4%). The results show that climatic changes …

Antibody Patents: Use Of The Written Description And Enablement Requirements At The Patent & Trademark Office, S. Sean Tu, Christopher M. Holman

Faculty Works

No abstract provided.

Cover And Contents

Turkish Journal of Biology

No abstract provided.

Emerging Applications Of 3d Engineered Constructs From Plant Seed Extracts, Sedat Odabaş, Bora Gari̇pcan, Rihab Ksouri

Turkish Journal of Biology

Seeds, by-products derived from various plants such as mango, quince, and apples, are considered waste, though they have emerging commercial potential, and have been used in biological, industrial, and physiological research. Seed-derived natural macromolecules- mainly polysaccharides, mucilage, gums, and cellulose-have physicochemical and structural diversification, giving the potential for forming gels, texturing, thickening, and providing interfacial adsorption. Seed-derived natural macromolecules have been widely used during the last few years in cell research and tissue engineering applications. Their widespread approachability and safety, high rate of biodegradability, biocompatibility, supporting cell proliferation, and extracellular matrix synthesis are the main properties making plant seed derivatives …

Linc00460 Mediates Hmga2 Expression Through Binding To Mirna-143-5p Competitively In Gastric Carcinoma, Xuqing Zhu, Yanli Xiang, Feifei Mo, Lingling Jin

Turkish Journal of Biology

Background: Compelling evidence has manifested a strong association between aberrant expression of long noncoding RNAs (lncRNAs) and gastric carcinoma (GC) development. Nonetheless, biological impacts of differentially expressed lncRNAs (DElncRNAs) on GC are not scrutinized. Methods: Bioinformatics methods were employed for differential expression analysis and target gene prediction. MTT, colony formation, and Transwell methods were implemented for GC cell proliferation, migration, and invasion assessment. Western blot was implemented to test the protein level. The binding of genes was tested with dual-luciferase and RNA binding protein immunoprecipitation (RIP) approaches. Results: Noticeably high level of LINC00460 was observed in GC tissues and cells. …

Boquila: Ngs Read Simulator To Eliminate Read Nucleotide Bias In Sequence Analysis, Ümi̇t Akköse, Ogün Adebali̇

Turkish Journal of Biology

Sequence content is heterogeneous throughout genomes. Therefore, genome-wide next-generation sequencing (NGS) reads biased towards specific nucleotide profiles are affected by the genome-wide heterogeneous nucleotide distribution. Boquila generates sequences that mimic the nucleotide profile of true reads, which can be used to correct the nucleotide-based bias of genome-wide distribution of NGS reads. Boquila can be configured to generate reads from only specified regions of the reference genome. It also allows the use of input DNA sequencing to correct the bias due to the copy number variations in the genome. Boquila uses standard file formats for input and output data, and it …

Acemannan-Containing Bioactive Resin Modified Glass Ionomer Demonstrates Satisfactory Physical And Biological Properties, Pasutha Thunyakitpisal, Aye Aye Thant, Polkit Sangvanich, Klaijan Inchudech, Nachanok Kuvieng, Salil Lalitkanjanakul

Journal of Dental Sciences

Abstract Background/purpose Resin-modified glass ionomers (RMGIs) have been recommended as liner and cement to provide the teeth with mechanical support, a chemical barrier, and thermal insulation. Acemannan, the main polysaccharide extracted from Aloe vera, is a promising inductive material in vitro and in vivo . This study aimed to develop acemannan-containing bioactive resin-modified glass ionomers (RMGIs). Materials and methods Acemannan (3%, 5%, and 10%) was added to the three types of RMGIs (RU-HBM1/Fuji II LC/Vitrebond) to generate 3%, 5%, and 10% aceRMGIs (aceRU/aceFuji/aceVB). The materials were evaluated for depth of cure/flexural strength/cumulative fluoride ion release. Cell viability and vascular endothelial …

A Child’S Constitutional Right To Family Integrity And Counsel In Dependency Proceedings, Rachel Kennedy

Emory Law Journal

Since the child welfare system’s inception, abuse and neglect laws have conflated poverty-related neglect with active parental violence and willful neglect. The ensuing state surveillance has disproportionately harmed poor children and children of color. Pursuant to the state’s expansive parens patriae authority, countless families are investigated, and thousands of children are separated from their caretakers each year—only to be returned within days or weeks after a finding that the reasons for removal were unsubstantiated. Other children risk drifting in foster care limbo until they experience the termination of parental rights—an adjudication so severe that some courts call it the “civil …

Genotyping Of The Κ - Casein Gene By Pcr - Rflp (Acui Digestion) And Its Relationship To Milk Yield Traits In Anatolian Buffaloes, Murrah Buffaloes, And Their Crosses, Orhan Karadağ, Vasfi̇ye Kader Esen, Mehmet Aki̇f Yüksel, Mustafa Küçükkebabçi, Semi̇h Sevi̇m, İlkay Çeti̇n, Bi̇nnur Kaptan, Mehmet İhsan Soysal

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to investigate the polymorphism of the κ - casein gene (kappa casein, CSN3) in buffaloes and determine its effects on milk yield traits. Data were obtained from 2016 to 2019 from all animals in the ongoing Anatolian Buffalo Breeding Project. Genomic DNA was collected from a total of 209 buffaloes of different ages and sexes, namely 31 Murrah, 46 Anatolian buffaloes, and 132 of their crosses (Murrah × Anatolian). Genotyping of CSN3 gene by polymerase chain reaction-restriction fragment length polymorphism (PCR - RFLP) technique with restriction enzyme (AcuI) revealed three …

Serum Trace Element Levels In Dogs With Canine Visceral Leishmaniasis, Aycan Nuri̇ye Gazyağci, Bengü Bi̇lgi̇ç, Berna Baysal Bakay, Duygu Tarhan, Alev Meltem Ercan, Songül Erdoğan, Hasan Erdoğan, Mehmet Erman Or, Kerem Ural

Turkish Journal of Veterinary & Animal Sciences

Canine visceral leishmaniasis has been denoted as neglected despite being a very well-known disease. Trace element alteration has been recognized in humans with visceral and cutaneous leishmaniasis, together with canine visceral leishmaniasis. The trace elements occupy a vital position in the immunological system, and host immune responses mitigate defense against leishmaniasis. We aimed to select trace elements in a total of 45 dogs of several breeds; those at the age of 11 months to 6 and from both sexes (26 male and 19 female) were enrolled in the study. The dogs included in the study were divided into leishmaniasis-infected and …

Cover And Contents

Turkish Journal of Chemistry

No abstract provided.

Polymeric Nanoparticle-Based Electrochemical Sensor For The Detection Of Ca 125, Ceren Türkcan, Si̇nan Akgöl

Turkish Journal of Chemistry

In this paper, Cys-graft-p(HEMA) nanomaterials and a new electrochemical method were developed for determination of CA 125. Cys-graft-p(HEMA) nanomaterials were synthesized with emulsion polymerization method and modified with grafting procedure. It was determined that Cys-graft-p(HEMA) nanomaterials had 50 nm dimension and spherical morphology, and per gram polymeric material contained 0.011 mmol L-cysteine. Electrode surface was prepared step by step for electrochemical analysis with optimization process. Linear determination range was determined as 5-400 U/mL (R= 0.9935). Detection limit (LOD) was calculated as 1.87 U/mL, and quantification limit (LOQ) was determined as 5.62 U/mL. The fabricated sensor system showed good repeatability, accuracy, …

Carbon Quantum Dots And Chitosan-Based Heterogeneous Silver Catalyst For Reduction Of Nitroaromatic Compounds, Farah Sami̇r Sali̇m, İdri̇s Sargin, Gülşi̇n Arslan

Turkish Journal of Chemistry

Chitosan plays a crucial role in catalysis, environmental remediation, and sustainable chemistry as a renewable and cationic polysaccharide. Chitosan-based metal catalysts are used in a broad range of chemical transformations. In the study, carbon quantum dots (CQDs) were derived from Momordica charantia fruits by microwave irradiation following a green chemistry approach. Three catalysts were designed: Ag(0)-chitosan, Ag(0)-chitosan-M. charantia fruit powder, and Ag(0)-chitosan-CQDs. The catalyst supports were prepared by stabilizing CQDs or M. charantia powder within the polymeric matrix of chitosan beads. Metallic silver particles were anchored onto glutaraldehyde cross-linked chitosan beads from the aqueous solution of silver nitrate. The …

Synthesis Optimization Of Zro2 Nanostructures For Photocatalytic Applications, Fi̇li̇z Boran, Merve Okutan

Turkish Journal of Chemistry

This study aims to optimize the synthesis of semiconductor zirconia (ZrO2) nanoparticles for future photocatalytic applications in degradation of pollutants in wastewater under ultraviolet (UV) light. The synthesis procedure of ZrO2 nanoparticles was optimized by examining the effects of synthesis methods (ultrasound-assisted, hydrothermal method in an autoclave and conventional precipitation), reaction time (2, 6, 10, and 18 h), ambient pH (3, 7, 10, 13), and surfactant type (anionic, cationic, and non-ionic), on the particle size and crystal phase of the nanomaterial. The characterization of the synthesized samples was performed by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), energy-dispersive X-ray …

In Vitro Tyrosinase Inhibitory, Dna Interaction Studies, And Lc?Hrms Analysis Of Ficus Carica Leaves, Güli̇n Renda, Burak Barut, Rümeysa Ceren, Enes Aydin

Turkish Journal of Chemistry

Turkey is the world?s leading producer of figs, a typical Mediterranean fruit. The fig, Ficus carica L. (Moraceae), has been widely cultivated since ancient times due to the nutritional value of its fruits. It was aimed to investigate the phytochemical characterization and biological properties of F. carica leaf extracts in order to determine their potential for use in the treatment of various diseases. F. carica leaves were extracted in 70% methanol at 40 °C under reflux. To obtain extracts of different polarities, the crude extract was fractionated with n-hexane, dichloromethane, and n-butanol. Phenolic content was determined using liquid chromatography?high resolution …

New Pyrimidine-N-Ss-D-Glucosides: Synthesis, Biological Evaluation, And Molecular Docking Investigations, Nuran Kahri̇man, Kivanç Peker, Vi̇ldan Serdaroğlu, Ali̇ Aydin, Burçi̇n Türkmenoğlu, Asu Usta, Nuretti̇n Yayli

Turkish Journal of Chemistry

In this study, syntheses of new pyrimidine-coupled N-ß-glucosides and tetra-O-acetyl derivatives were carried out. All glycoconjugates were investigated in comparison with known chemotherapeutic agents in terms of their antimicrobial and anticancer functions and DNA/protein binding affinities. Spectral data showed that all glycoside derivatives were obtained by diastereoselectivity as ß-anomers. Both tested groups exhibited strong antiproliferative activity (2.29?66.84 ?g/mL), but some of them had sufficiently ideal % cytotoxicity values (10.01%?16.78%). And also all synthetic compounds exhibited remarkable antibacterial activity against human pathogenic bacteria. Binding of these compounds to CT-DNA resulted in significant changes in spectral properties, consistent with groove binding. Molecular …

Theoretical Investigation Of Steric Effects On The S1 Potential Energy Surface Of O-Carborane-Anthracene Derivatives, Fahri̇ Alkan

Turkish Journal of Chemistry

TDDFT scan calculations were performed for s-carborane-anthracene derivatives (o-CB-X-Ant where X=-H, -CH3, -C2H5 and tert-butyl or -tBu) in order to understand the interplay between the steric effects, S1 potential energy surface (PES) and photophysical properties. The results show that all systems exhibit three local minima on the S1 PES, which correspond to the emissive LE and TICT state, along with the nonemissive CT state respectively. In the case of the unsubstituted system (o-CB-H-Ant), and -CH3 and -C2H5 substituted cases, S1 PES is predicted to be quite flat for certain conformations indicating that it is possible for these systems to reach …

Evaluation Of Leishmanicidal Activities Of 4-Thiazolidinones Against Leishmania Major, The Causative Agent Of Human Cutaneous Leishmaniasis, Kiera Bush

All Master's Theses

The leishmaniases are a group of vector-borne parasitic diseases that affect many developing countries including parts of Africa, India, and the Middle East in addition to Southern Europe and the Americas. It is estimated that worldwide, there are about 3 million new cases of leishmaniases each year leading to as many as 50,000 fatalities annually. The parasites that cause leishmaniasis belong to the genus Leishmania spp and are transmitted by the female phlebotomine sand fly. There are three clinical forms of the infection: visceral, mucocutaneous, and cutaneous. However, the focus of this paper is on cutaneous leishmaniasis that causes skin …

Does Apocynin Increase Liver Regeneration In The Partial Hepatectomy Model?, Yilmaz Bi̇lgi̇ç, Burhan Hakan Kanat, Onural Özhan, Azi̇be Yildiz, Zeynep Aksungur, Mehmet Erman Erdemli̇, Ni̇gar Vardi, Yusuf Türköz, Ahmet Sami̇ Akbulut, Adem Köse, Hakan Parlakpinar

Turkish Journal of Medical Sciences

Background/aim: Hepayocyte loss may develop secondary to liver surgery and at this point liver regeneration plays a significant act in terms of liver reserve. The purpose of this research was to investigate the efficacy of apocynin on liver regeneration and preservation after partial hepatectomy in rats. Materials and methods: A total of 32 rats, have been divided into 4 groups (n: 8) for hepatectomy model. Inflammatory and antiinflammatory parameters were measured from blood and liver tissue samples. In addition, the effects of apocynin were examined immunohistochemically and histopathologically from liver tissue. Results: In liver tissue samples, a significant difference has …

Investigation Of Igf-1, Igf-Bp3 And Igf-Bp5 Levels In Umbilical Cord Blood Of Infants With Developmental Dysplasia Of The Hip, Esra Demi̇rel, Eyüp Şenocak, Gamze Nur Ci̇mi̇lli̇ Şenocak, Ali̇ Şahi̇n, Berri̇n Göktuğ Kadioğlu, Özlem Gündüz

Turkish Journal of Medical Sciences

Background/aim: IGF-1 (insulin-like growth factor-1) is an important regulator of bone formation. Its deficiency has been associated with fetal growth disorders and hip dysplasia. The aim of this study was to evaluate whether IGF-1, IGF-BP3 (insulin like growth factorbinding protein 3), and IGF-BP5 levels in the umbilical cord blood can be predictive for early diagnosis of DDH. Materials and methods: Umbilical cord blood samples were collected from 860 mothers with pregnancies at high risk for DDH between October 2020 and January 2021. Mothers at 37-42 weeks of gestation, with risk factors for DDH, who delivered healthy infants were included. Blood …

What Is The Impact Of Inflammasome Mechanisms On Male Infertility?, Eser Ördek, Bülent Kati, İsmai̇l Koyuncu, Mehmet Demi̇r, İsmai̇l Yağmur, Eyyup Sabri̇ Peli̇t, Hali̇l Çi̇ftçi̇, Ercan Yeni̇

Turkish Journal of Medical Sciences

Background/aim: Mechanisms to explain inflammation in male infertility of unknown cause are still being investigated. The inflammasome is a key regulator of innate immunity in the inflammatory response to infections. Our study aims to investigate the effects of varicocele on infertility, its relationship with antioxidant and inflammasome mechanisms, and how it could be guided in azoospermic or nonazoospermic patients. Materials and methods: A cross-sectional cohort study was conducted at the department of urology in our university hospital. Eightyeight randomly selected men aged 20-45 admitted to our hospital because of infertility between September 2019 and July 2020 were included in the …

Texture Analysis Of Multiparametric Magnetic Resonance Imaging For Differentiating Clinically Significant Prostate Cancer In The Peripheral Zone, Hali̇l Özer, Mustafa Koplay, Ahmet Baytok, Nusret Seher, Lütfi̇ Saltuk Demi̇r, Abi̇di̇n Kilinçer, Mehmet Kaynar, Serdar Göktaş

Turkish Journal of Medical Sciences

Background/aim: Texture analysis (TA) provides additional tissue heterogeneity data that may assist in differentiating peripheral zone (PZ) lesions in multiparametric magnetic resonance imaging (mpMRI). This study investigates the role of magnetic resonance imaging texture analysis (MRTA) in detecting clinically significant prostate cancer (csPCa) in the PZ. Materials and methods: This retrospective study included 80 consecutive patients who had an mpMRI and a prostate biopsy for sus- pected prostate cancer. Two radiologists in consensus interpreted mpMRI and performed texture analysis based on their histopathology. The first-, second-, and higher-order texture parameters were extracted from mpMRI and were compared between groups. Univariate …

Multidrug Resistance In Pathogens Of Community-Acquired Urinary Tract Infections In Turkey: A Multicentre Prospective Observational Study, İrfan Şencan, Oğuz Karabay, Fatma Aybala Altay, Serap Süzük Yildiz, Hüsni̇ye Şi̇mşek, Meli̇h Gaffar Gözükara, Semanur Kuzi̇, Gülden Eser Karlidağ, Şafak Kaya, Gülnur Kul, Emi̇ne Türkoğlu, Büşra Ergüt Sezer, Nesi̇be Korkmaz, Si̇bel Yildiz Kaya, Merve Sefa Sayar

Turkish Journal of Medical Sciences

Background/aim: To have country-wide information about multidrug resistance (MDR) in isolates from community-acquired urinary tract infections (CAUTI) of Turkey, in terms of resistance rates and useful options. Materials and methods: We used a geocode standard, nomenclature of territorial units for statistics (NUTS), and a total of 1588 community-acquired isolates of 20 centres from 12 different NUTS regions between March 2019 and March 2020 were analysed. Results: Of the 1588 culture growths, 1269 (79. 9%) were Escherichia coli and 152 (9.6%) were Klebsiella spp. Male sex, advanced age, and having two or more risk factors showed a statistically significant relation with …

Reading In Place: Ordinary Language Philosophy, Wendell Berry, And Post Critique, Calvin L. Coon

Graduate Theses/Dissertations

The twenty-first century, marked by neoliberalism and suspicious, visibly violent far-Right politics, has presented new challenges to critical and literary theorists. In response, some theorists advocate for a postcritical turn, challenging both the surface/depth picture of language and the privileged status of suspicion in interpretation in order to explore alternative pictures of language and reading that can better address the challenges of our own day. In this thesis, I connect one of these alternatives, Toril Moi’s use of Ordinary Language Philosophy in literary studies, to Wendell Berry’s prioritization of place in environmentalist activism. In connecting these two thinkers, I contend …

In The Thick(Et) Of It: Addressing Biologic Patent Thickets Using The Sham Exception To Noerr-Pennington, Anna Zhou

Fordham Intellectual Property, Media and Entertainment Law Journal

A biologic patent thicket occurs when a pharmaceutical company acquires a “dense web” of patents and other intellectual property rights regarding a specific product. While applying for multiple patents is permissible, the resulting protections can have antitrust implications. In an industry like biologics, where companies can acquire patent exclusivity and regulatory exclusivity over their products, the process of continuously accumulating these exclusivities seems to be an attempt to keep biosimilars at bay. Keeping competitors out of the market drives up prices and raises questions about how these regulatory and patent pathways are being used.

Recent class action litigation in the …

Silly Gene Patent Is Not My Lover: A Retrospective Analysis Of Myriad, Stephanie Huang

Fordham Intellectual Property, Media and Entertainment Law Journal

The U.S. Supreme Court’s decision in Association for Molecular Pathology v. Myriad Genetics, Inc. established that an isolated fragment of a gene—the basic unit of heredity—is not patent-eligible subject matter while simultaneously holding that complementary DNA (cDNA) of a gene is patent-eligible subject matter. The decision has been controversial and criticized for including two holdings that are internally inconsistent from both scientific and patent law perspectives. But are the short- and long-term criticisms overstated? A decade after Myriad, the various impacts of the case remain relevant, particularly to the biotechnology and genetic testing fields.

First, this Note examines whether Myriad …