Digital Commons Network^™

Are Biodiverse Communities More Resistant To Invasion? A Case Study With Marine Fouling Communities, Taylor Robert Bruntil

Cal Poly Humboldt theses and projects

The theory of biotic resistance predicts that more diverse communities should be less susceptible to invasion by novel species, but given the opposing results of multiple observational and experimental studies in marine systems, it is unclear how changes in environmental conditions can affect invasion success in communities that differ in diversity. I used marine fouling communities to test how the diversity of the species present in an initial community (hereafter termed “resident species”) affected the establishment and growth of all species not present in the initial communities (hereafter termed “novel species”) at two locations at the Eureka Public Marina, in …

Community Ecology And Disease Dynamics In Pacific Oysters: Unraveling Microbiome-Pathogen Interactions In The Wild, Victoria E. Cifelli

Cal Poly Humboldt theses and projects

In the context of multispecies microbial assemblages, disruptions can occur when there are alterations in host conditions, such as the onset of a disease. Notably, viruses have the potential to reshape a host's microbial community. However, the role of the host's habitat and environment, which could be pivotal in communities with shifting niche space and habitat filters, is often overlooked in host-microbe-pathogen interactions. Recognizing the importance of these factors, I employed a field-based approach to understand microbial community dynamics in the presence of disease. To address the influence of geographical location, I conducted an analysis involving healthy and infected oysters …

Probing The Porphyromonas Gingivalis Nitrosative Stress Response Network, Alexandra Galina

Theses and Dissertations

Objective: To persist in the oral cavity, the perio-pathogen Porphyromonas gingivalis must have an efficient nitrosative stress response mechanism. To better understand how P. gingivalis responds to nitrite (NO₂^-) we must determine what genes are involved in the nitrosative stress response network.

Methods: Through genomic screening, a list of genes was generated that were hypothesized to be part of the nitrosative stress response network and believed to be involved in nitrate/nitrite metabolism or redox state of the cells. Protein coding regions were replaced with the ermF sequence by allelic exchange mutagenesis. 15 mutants were created …

Sustaining Breaths For Restorative Rest: A Preliminary Evaluation Of Sleep, Mental Health, And Cognitive Function Following Hypoglossal Nerve Stimulation For Obstructive Sleep Apnea, Elliottnell Perez

Theses and Dissertations

Introduction: Obstructive sleep apnea (OSA) is a sleep-related breathing disorder that produces repetitive obstruction or collapse of the upper airway. Positive airway pressure (PAP) therapy is the gold standard treatment for OSA. Hypoglossal nerve stimulation (HNS) is considered an alternative treatment for patients who are unable to tolerate PAP therapy. The purpose of the study was to examine sleep, mental health, and cognitive health outcomes before and after HNS to determine its viability as an alternative treatment.

Methods: The study utilized a single-group, pretest-posttest design. Objective and subjective sleep was measured using actigraphy, sleep diary, and questionnaires. Objective and subjective …

Machine Learning Models To Automate Radiotherapy Structure Name Standardization, Priyankar Bose

Theses and Dissertations

Structure name standardization is a critical problem in Radiotherapy planning systems to correctly identify the various Organs-at-Risk, Planning Target Volumes and `Other' organs for monitoring present and future medications. Physicians often label anatomical structure sets in Digital Imaging and Communications in Medicine (DICOM) images with nonstandard random names. Hence, the standardization of these names for the Organs at Risk (OARs), Planning Target Volumes (PTVs), and `Other' organs is a vital problem. Prior works considered traditional machine learning approaches on structure sets with moderate success. We compare both traditional methods and deep neural network-based approaches on the multimodal vision-language prostate cancer …

Community On Campus: Examining The Impact Of Campus Climate, Belonging, And Flourishing On Bystander Behavior Among Diverse University Students, Amelia Liadis

Theses and Dissertations

This exploratory, nonexperimental study aimed to investigate the relationships among diverse undergraduate and graduate students’ perceived campus climate, flourishing, and university belonging on bystander intentions and bystander behaviors during the COVID-19 pandemic. The study’s theoretical framework combined the Theory of Planned Behavior and feminist theory, and examined intersectionality through an Identity Risk Index. Data used in the current study were originally collected as part of an institutional Healthy Minds Survey, on health behaviors of college students; responses from n = 171 of the randomly selected participants were used in the current study’s analyses. The majority of participants indicated at least …

Supporting Students Who Are Deafblind To Increase Their Access To The General Education Curriculum Through Trained Interveners: A Mixed Methods Study, Ira Padhye

Theses and Dissertations

The purpose of this mixed-methods research study was to identify the educational trends of children and young adults who are deafblind and identify strategies to improve the outcomes through interviews of nationally qualified interveners who have received training in deafblind specific strategies. Secondary data from the 2017-2021 National Center on Deafblindness and interview transcripts were used for data analysis and then integrated to identify the supports students who are deafblind should access. Trends in age of identification, primary eligibility category, school settings and access to state standardized assessments showed a plateau and displayed no significant improvement in educational outcomes. Nationally …

Getting To Trustworthiness (But Not Necessarily To Trust), Helen L. Norton

Publications

As ethicist and political scientist Russell Hardin observed, our willingness to trust an actor generally turns on our own experience with, and thus our own perceptions of, that actor’s motives and that actor’s competence. Changes over time and technology can alter our experience with a particular actor and thus our willingness to trust or distrust that actor.

This symposium essay focuses not on how to encourage the public to trust the media, but instead on how the media’ can behave in trustworthy ways--in other words, how its choices can demonstrate its trustworthy motives and competence. Examples include refusing to amplify …

Skin-Derived Abcb5+ Mesenchymal Stem Cells For High-Medical-Need Inflammatory Diseases: From Discovery To Entering Clinical Routine, Elke Niebergall-Roth, Natasha Y. Frank, Christoph Ganss, Markus H. Frank, Mark A. Kluth

Research outputs 2022 to 2026

The ATP-binding cassette superfamily member ABCB5 identifies a subset of skin-resident mesenchymal stem cells (MSCs) that exhibit potent immunomodulatory and wound healing-promoting capacities along with superior homing ability. The ABCB5+ MSCs can be easily accessed from discarded skin samples, expanded, and delivered as a highly homogenous medicinal product with standardized potency. A range of preclinical studies has suggested therapeutic efficacy of ABCB5+ MSCs in a variety of currently uncurable skin and non-skin inflammatory diseases, which has been substantiated thus far by distinct clinical trials in chronic skin wounds or recessive dystrophic epidermolysis bullosa. Therefore, skin-derived ABCB5+ MSCs have the potential …

Early Mortality Among Aboriginal And Non-Aboriginal Women Who Had A Preterm Birth In Western Australia: A Population-Based Cohort Study, Helen D. Bailey, Caitlin Gray, Akilew A. Adane, Natalie A. Strobel, Scott W. White, Rhonda Marriott, Gizachew A. Tessema, Carrington C. J. Shepherd, Mary Sharp

Research outputs 2022 to 2026

Background: Having a preterm ( < 37 weeks' gestation) birth may increase a woman's risk of early mortality. Aboriginal and Torres Strait Islander (hereafter Aboriginal) women have higher preterm birth and mortality rates compared with other Australian women. Objectives: We investigated whether a history of having a preterm birth was associated with early mortality in women and whether these associations differed by Aboriginal status. Methods: This retrospective cohort study used population-based perinatal records of women who had a singleton birth between 1980 and 2015 in Western Australia linked to Death Registry data until June 2018. The primary and secondary outcomes were all-cause and cause-specific mortality respectively. After stratification by Aboriginal status, rate differences were calculated, and Cox proportional hazard regression was used to estimate adjusted hazard ratios (HR) and 95 % confidence intervals (CI) for all-cause and cause-specific mortality. Results: There were 20,244 Aboriginal mothers (1349 deaths) and 457,357 non-Aboriginal mothers (7646 deaths) with 8.6 million person-years of follow-up. The all-cause mortality rates for Aboriginal mothers who had preterm births and term births were 529.5 and 344.0 (rate difference 185.5, 95 % CI 135.5, 238.5) per 100,000 person-years respectively. Among non-Aboriginal mothers, the corresponding figures were 125.5 and 88.6 (rate difference 37.0, 95 % CI 29.4, 44.9) per 100,000 person-years. The HR for all-cause mortality for Aboriginal and non-Aboriginal mothers associated with preterm birth were 1.48 (95 % CI 1.32, 1.66) and 1.35 (95 % CI 1.26, 1.44), respectively, compared with term birth. Compared with mothers who had term births, mothers of preterm births had higher relative risks of mortality from diabetes, cardiovascular, digestive and external causes. Conclusions: Both Aboriginal and non-Aboriginal women who had a preterm birth had a moderately increased risk of mortality up to 38 years after the birth, reinforcing the importance of primary prevention and ongoing screening.

The Socio-Economic Impact Of Marine Protected Areas In Jersey: A Fishers’ Perspective, Samantha R. Blampied, Emma V. Sheehan, Martin J. Attrill, Francis C.T. Binney, Sian E. Rees

School of Biological and Marine Sciences

No abstract provided.

A Two Way Process – Social Capacity As A Driver And Outcome Of Equitable Marine Spatial Planning, Céline Jacob, Diederichsen S Duprey, Liam Fullbrook, Amanda T. Lombard, Siân E. Rees, Nina Rivers, Bernadette Snow, Mia Strand, Rachel Zuercher, Holly J. Niner

School of Biological and Marine Sciences

Although stakeholder engagement is one of the founding principles of marine spatial planning (MSP), meaningful representation of people and their connections to marine resources within marine governance is still lacking. A broad understanding of how concepts surrounding social capital and capacity is translated into MSP practice is missing. With this article, we describe detailed case studies in the United Kingdom, Brazil and South Africa to build a better understanding of the ways in which MSP and other ocean governance initiatives operationalise the concepts of social capital and capacity. Drawing on insights from the cases, we call for a rethinking of …

Inhibition Of Yap/Taz-Driven Tead Activity Prevents Growth Of Nf2-Null Schwannoma And Meningioma, Liyam Laraba, Lily Hillson, Julio Grimm De Guibert, Amy Hewitt, Maisie R Jaques, Tracy T Tang, Leonard Post, Emanuela Ercolano, Ganesha Rai, Shyh-Ming Yang, Daniel J Jagger, Waldemar Woznica, Philip Edwards, Aditya G Shivane, C Oliver Hanemann, David B Parkinson

Peninsula Medical School

Schwannoma tumours typically arise on the eighth cranial nerve and are mostly caused by loss of the tumour suppressor Merlin (NF2). There are no approved chemotherapies for these tumours and the surgical removal of the tumour carries a high risk of damage to the eighth or other close cranial nerve tissue. New treatments for schwannoma and other NF2-null tumours such as meningioma are urgently required. Using a combination of human primary tumour cells and mouse models of schwannoma, we have examined the role of the Hippo signalling pathway in driving tumour cell growth. Using both genetic ablation of the Hippo …

Investigating Pre-Professional Dancer Health Status And Preventative Health Knowledge, Joanna Nicholas, Sara Grafenauer

Research outputs 2022 to 2026

Introduction: Dance is a highly demanding physical pursuit coupled with pressure to conform to aesthetic ideals. Assessment of health status and preventative health knowledge of pre-professional dancers may help inform educational strategies promoting dancers’ health and career longevity. The aim of this research was to establish a baseline understanding of dance students at a single pre-professional institution based on metrics focused on current health, nutrition, lifestyle, and wellbeing while also gauging knowledge of longer-term health implications. Methods: Adopting a cross-sectional study design, the Dance-Specific Energy Availability Questionnaire was tailored for Australian participants and administered online. Results: The response rate was …

Proteomic Exploration Reveals A Metabolic Rerouting Due To Low Oxygen During Controlled Germination Of Malting Barley (Hordeum Vulgare L.), Clare E. O'Lone, Angéla Juhász, Mitchell Nye-Wood, Hugh Dunn, David Moody, Jean-Philippe Ral, Michelle L. Colgrave

Research outputs 2022 to 2026

Barley (Hordeum vulgare L.) is used in malt production for brewing applications. Barley malting involves a process of controlled germination that modifies the grain by activating enzymes to solubilize starch and proteins for brewing. Initially, the grain is submerged in water to raise grain moisture, requiring large volumes of water. Achieving grain modification at reduced moisture levels can contribute to the sustainability of malting practices. This study combined proteomics, bioinformatics, and biochemical phenotypic analysis of two malting barley genotypes with observed differences in water uptake and modification efficiency. We sought to reveal the molecular mechanisms at play during controlled germination …

Utilizing Proteomics To Identify And Optimize Microalgae Strains For High-Quality Dietary Protein: A Review, Sara Hamzelou, Damien Belobrajdic, James A. Broadbent, Angéla Juhász, Kim L. Chang, Ian Jameson, Peter Ralph, Michelle L. Colgrave

Research outputs 2022 to 2026

Algae-derived protein has immense potential to provide high-quality protein foods for the expanding human population. To meet its potential, a broad range of scientific tools are required to identify optimal algal strains from the hundreds of thousands available and identify ideal growing conditions for strains that produce high-quality protein with functional benefits. A research pipeline that includes proteomics can provide a deeper interpretation of microalgal composition and biochemistry in the pursuit of these goals. To date, proteomic investigations have largely focused on pathways that involve lipid production in selected microalgae species. Herein, we report the current state of microalgal proteome …

Feeling And Hearing Country As Research Method, Anne Poelina, Marlikka Perdrisat, Sandra Wooltorton, Edwin L. Mulligan

Research outputs 2022 to 2026

This paper explains Feeling and Hearing Country as an Australian Indigenous practice whereby water is life, Country is responsive, and Elders generate wisdom for a communicative order of things. The authors ask, as a society of Indigenous people and those no longer Indigenous to place, can we walk together in the task of collectively healing Country? The research method uses experiential, creative, propositional, and practical ways of knowing and being in and with local places. Evidence may take many forms based upon engagement with an animate, sentient world. The research method can generate new meanings, implications and insights, and regenerate …

More Than Energy Cost: Multiple Benefits Of The Long Achilles Tendon In Human Walking And Running, Anthony J. Blazevich, Jared R. Fletcher

Research outputs 2022 to 2026

Elastic strain energy that is stored and released from long, distal tendons such as the Achilles during locomotion allows for muscle power amplification as well as for reduction of the locomotor energy cost: as distal tendons perform mechanical work during recoil, plantar flexor muscle fibres can work over smaller length ranges, at slower shortening speeds, and at lower activation levels. Scant evidence exists that long distal tendons evolved in humans (or were retained from our more distant Hominoidea ancestors) primarily to allow high muscle–tendon power outputs, and indeed we remain relatively powerless compared to many other species. Instead, the majority …

Sixteen-Year Longitudinal Evaluation Of Blood-Based Dna Methylation Biomarkers For Early Prediction Of Alzheimer's Disease, Fernanda Schäfer Hackenhaar, Maria Josefsson, Annelie Nordin Adolfsson, Mattias Landfors, Karolina Kauppi, Tenielle Porter, Lidija Milicic, Simon M. Laws, Magnus Hultdin, Rolf Adolfsson, Sofie Degerman, Sara Pudas, Australian Imaging Biomarkers And Lifestyle Study

Research outputs 2022 to 2026

BACKGROUND: DNA methylation (DNAm), an epigenetic mark reflecting both inherited and environmental influences, has shown promise for Alzheimer's disease (AD) prediction. OBJECTIVE: Testing long-term predictive ability ( > 15 years) of existing DNAm-based epigenetic age acceleration (EAA) measures and identifying novel early blood-based DNAm AD-prediction biomarkers. METHODS: EAA measures calculated from Illumina EPIC data from blood were tested with linear mixed-effects models (LMMs) in a longitudinal case-control sample (50 late-onset AD cases; 51 matched controls) with prospective data up to 16 years before clinical onset, and post-onset follow-up. Novel DNAm biomarkers were generated with epigenome-wide LMMs, and Sparse Partial Least Squares …

Kind Regards: Negotiating Connection To Country And Place Through Collective Storying, Wendy Somerville, Vahri Mckenzie, Lisa Fuller, Naomi Joy Godden, Ashley Harrison, Renae Isaacs-Guthridge, Bethaney Turner

Research outputs 2022 to 2026

Within this paper we explore the process and outcomes of a year-long exchange that investigates how active learning can emerge through collective place-based storying. Beginning with Country as our guide, we shared, responded, yarned, listened and revisited one another's contributions. Using the "threads"of an extended email exchange and online yarning sessions, we wove together this collaborative work to present findings generated from the creative practice of storying and sharing knowledge. This work required ongoing openness to vulnerability; we resisted the urge to remain silent and risked being wrong. Our responses, and the writing styles reflecting them, incorporate both academic and …

Understanding Optimisation Processes With Biologically-Inspired Visualisations, Mathew Walter

School of Engineering, Computing and Mathematics Theses

Evolutionary algorithms (EAs) constitute a branch of artificial intelligence utilised to evolve solutions to solve optimisation problems abound in industry and research. EAs often generate many solutions and visualisation has been a primary strategy to display EA solutions, given that visualisation is a multi-domain well-evaluated medium to comprehend extensive data. The endeavour of visualising solutions is inherent with challenges resulting from high dimensional phenomenons and the large number of solutions to display. Recently, scholars have produced methods to mitigate some of these known issues when illustrating solutions. However, one key consideration is that displaying the final subset of solutions exclusively …

Employability For Inclusion: The Urgent Need For A Biopsychosocial Model Perspective, Mollie Dollinger, Tim Corcoran, Denise Jackson, Sarah O'Shea

Research outputs 2022 to 2026

Definitions of disability are changing, shifting from a narrow medical diagnosis to a biopsychosocial model of disability, where disability is conceptualised as a series of relational conditions that can potentially disadvantage individuals within environments. Implications of this new understanding of disability will have significant effects in the higher education sector, where there is increasing participation of disabled students. In this paper, we discuss one aspect of these implications through the topic of graduate employability. In doing so, we generate a new concept ‘Employability for Inclusion’ that can be utilised as an equity-focused lens for universities to consider how employability initiatives …

Case Report: Sex-Specific Characteristics Of Epilepsy Phenotypes Associated With Xp22.31 Deletion: A Case Report And Review, Yi Wu, Dan Wu, Yulong Lan, Shaocong Lan, Duo Li, Zexin Zheng, Hongwu Wang, Lian Ma

Research outputs 2022 to 2026

Deletion in the Xp22.31 region is increasingly suggested to be involved in the etiology of epilepsy. Little is known regarding the genomic and clinical delineations of X-linked epilepsy in the Chinese population or the sex-stratified difference in epilepsy characteristics associated with deletions in the Xp22.31 region. In this study, we reported two siblings with a 1.69 Mb maternally inherited microdeletion at Xp22.31 involving the genes VCX3A, HDHD1, STS, VCX, VCX2, and PNPLA4 presenting with easily controlled focal epilepsy and language delay with mild ichthyosis in a Chinese family with a traceable 4-generation history of skin ichthyosis. Both brain magnetic resonance …

The Digital Environmental Humanities (Deh) In The Anthropocene: Challenges And Opportunities In An Era Of Ecological Precarity, John Ryan, Lydia Hearn, Paul Arthur

Research outputs 2022 to 2026

Researchers in the complementary fields of the digital humanities and the environmental humanities have begun to collaborate under the auspices of the digital environmental humanities (DEH). The overarching aim of this emerging field is to leverage digital technologies in understanding and addressing the urgencies of the Anthropocene. Emphasizing DEH’s focus on natural and cultural vitality, this article begins with a historical overview of the field. Crafting an account of the field’s emergence, we argue that the present momentum toward DEH exhibits four broad thematic strains including perennial eco-archiving; Anthropocene narratives of loss; citizen ecohumanities; and human-plant-environment relations. Within each of …

Immersive Multidimensional Data Visualisation Using Geon Based Objects, Marius Varga

School of Engineering, Computing and Mathematics Theses

In an ever-expanding technologically driven society large amounts of data are being generated daily. The sheer volume of data is becoming a challenge to understand or use in the decision-making process. This is not only limited to businesses, politicians or scientists but it is becoming more relevant to the general public as well. The data has become a commodity, but its value is closely tied to our ability, as data owners, to extract meaning from it. Typically, the process is complex and mainly reserved for proficient data scientists who are familiar with the process of extracting information and the specialised …

Moment-Based Reinforcement Learning For Ensemble Control, Yao-Chi Yu, Vignesh Narayanan, Jr-Shin Li

Publications

Problems involving controlling the collective behavior of a population of structurally similar dynamical systems, the so-called ensemble control, arise in diverse emerging applications and pose a grand challenge in systems science and control engineering. Owing to the severely under-actuated nature and the difficulty of placing large-scale sensor networks, ensemble systems are limited to being actuated and monitored at the population level. Moreover, mathematical models describing the dynamics of ensemble systems are often elusive. Therefore, it is essential to design broadcast controls that excite the entire population in such a way that the heterogeneity in system dynamics are robustly compensated. In …

Child Development And The Family Regulation System, Clare Huntington

Faculty Scholarship

Child abuse and neglect clearly harm children, but the risks that accompany involvement with the family regulation system (also known as the child welfare system), especially placement in foster care, also present considerable risks to child development. This chapter describes these competing risks to child development, the legal framework governing the family regulation system, and scholarly debates in the field. It then analyzes the system in the broader context of the legal regulation of children, showing that the family regulation system is out of step with other areas and in need of significant reform. A core problem with the system …

2023 Spring Commencement, Georgia Southern University

Commencement Programs

No abstract provided.

Summary Of Aboriginal And Torres Strait Islander Health Status - Selected Topics 2022, Australian Indigenous Healthinfonet

Research outputs 2022 to 2026

The Summary of Aboriginal and Torres Strait Islander health status - selected topics 2022 (Summary) is a useful resource for those working or studying in the Aboriginal and Torres Strait Islander health sector. It provides general information regarding the health status of Aboriginal and Torres Strait Islander people covering the following topics:

• the Aboriginal and Torres Strait Islander population
• determinants of health
• information pertaining to births and pregnancy, deaths and hospitalisation
• burden of disease
• chronic conditions including cardiovascular disease, cancer, diabetes, kidney and respiratory health
• social and emotional wellbeing (including mental health)
• selected sexually transmissible infections
• environmental health
• tobacco and …

Difference Between Scheduled And Non Scheduled Banks [Upsc Notes], Byju's

Documents

No abstract provided.