Digital Commons Network^™

Cul3 Negatively Regulates Nlrp12-Mediated Inhibition Of The Canonical Nf-Κb Signaling Pathway, Inyeong Lee

Graduate Theses/Dissertations

Nod-like receptor family pyrin domain-containing protein 12 (NLRP12) is mainly known for its inhibitory function on NF-κB signaling in innate immune cells, and more recently, for its ability to regulate chemokine signaling and ubiquitination of the immune receptor RIG-I. Through a yeast 2-hybrid screen, the Lupfer lab previously discovered that NLRP12 interacts with other ubiquitin-associated proteins including Cullin 3 (CUL3) and RING finger protein 2 (RNF2). This research was conducted to mainly investigate the interaction between NLRP12 and CUL3 in human cells and examine the role in regulating NF-κB signaling. Previously, co-immunoprecipitation, followed by western blot analysis, and confocal microscopy …

Morphological And Genetic Analysis Of The Root System In Two American Grapevines (Vitis Species), Parinaz Mohtasebi

Graduate Theses/Dissertations

The North American grapes species Vitis rupestris Scheele and Vitis riparia Michx have been the pillars of rootstock breeding for many decades. Though a large body of viticultural knowledge has been accumulated on their impact on grafted scions, the genetic basis of their root system architecture (RSA) has received limited scientific attention. In this study, I generated and analyzed adventitious root systems from dormant cuttings of 22 V. riparia and 19 V. rupestris accessions, as well as 162 interspecific F1 hybrid progeny from a cross between V. rupestris (♀) and V. riparia (♂). I photographed the roots and then extracted …

Influence Of Cell Cycle On Aim2 Inflammasome Activation, Ashok Kumar Dubey

Graduate Theses/Dissertations

A cell cycle's progression has a significant role in the development of a disease. All the signaling pathways and inflammatory reactions are maintained in a healthy mode if cell cycle checkpoints are precisely regulated and kept in homeostasis. AIM2 inflammasome is a cytoplasmic double-stranded DNA sensor. Upon activation, it elicits an inflammatory reaction with the release of pro-inflammatory cytokines such as IL-1β and IL-18 and they are cleaved by the proteases, Caspase-1 from their inactive form. Also, the AIM2 inflammasome helps in regulating cell division and inhibits cell proliferation; thus, leading to a cell death called pyroptosis. Here, I examined …

Distribution Patterns Of Allorhizobium Vitis In Missouri Vineyards And Non-Vineyard Soils, Jacquelyn M. Wray

Graduate Theses/Dissertations

Crown gall disease causes significant economic loss to the grape and wine industry. Preventive strategies are most effective for mitigating the loss of grapevines in vineyards, as there is no known cure for this disease. The bacterium Allorhizobium vitis carrying a tumor-inducing (Ti) plasmid is the causative agent. A. vitis bacteria live systemically in the grapevine before causing visible symptoms and can survive in residual plant tissues and soil for more than two years. Diagnostic methods have been developed to detect A. vitis bacteria in grapevines and soil. However, more reliable, specific, and high-throughput diagnostics are still needed for screening …

Disparities In Mental Health Technology Among African Americans: Breaking Cultural Inclusion Barriers, Nyoki Cosey-Brown

DSW Capstone Projects

Mental health technology is a healthcare delivery model of the future. The engagement in virtual healthcare was intensified when traditional healthcare methods were inaccessible during the federal restrictions implemented due to the COVID-19 pandemic. Utilizing digital apparatuses for healthcare improved the convenience, efficiency, and accessibility of various mental health services that were inoperable in past healthcare models. However, the historical constructs of stigma, discrimination, inequity, exclusion, and structural racism in mental healthcare were prevalent problems that remained present in virtual mental health platforms concerning the experiences of African-American patients and professionals who utilized the spaces.

This research explored mental health …

State Level Mental Health Education Compared To Suicide-Related Behavior In Adolescents, 2019, Sonia Rao

Honors Theses

Objective: Determining correlations between state level mental and emotional health (M&E) education and suicide prevention (SP) education to suicide-related behaviors (I.e. feeling sad or hopeless, suicide ideation, making a suicide plan, suicide attempt, suicide attempt treated by medical personnel, and death by suicide) within high school adolescents aged 15-19 within the United States in 2019.

Methods: State level education policies, M&E and SP, were retrieved from the National Association of State Boards of Education (NASBE). Self-reported adolescent suicide related behaviors were retrieved from the 2019 Youth Risk Behavior Surveillance System (YRBSS). Data on deaths by suicide of youth aged 15-19 …

Prediction Of Single Proppant Terminal Settling Velocity In High Viscosity Friction Reducers By Using Artificial Neural Networks And Xgboost, Xiaojing Ge, Rong Lu, Ghith Biheri, Abdulmohsin Imqam, Baojun Bai

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

High viscosity friction reducers (HVFRs) have been recently gaining more attention and increasing in use, not only as friction-reducing agents but also as proppant carriers. The settling velocity of the proppant is one of the key outputs to describe their proppant transport capability. However, it is influenced by many factors such as fluid properties, proppant properties, and fracture properties. Many empirical/physics-based models and correlations to predict particle settling velocity have been developed. However, they are usually based on certain assumptions and have applicable limits. In contrast, machine learning models can be considered as a black box. The objective of this …

Soft X-Ray And Susceptibility Based Magnetic Resonance Imaging To Map Iron Distribution In Apples: Initial Results To Model Iron Storage In Water-Deficient Or Dehydrated Biological Tissue, Subhendra Sarkar, Eric Lobel, Evans Lespinasse, Zoya Vinokur, Analia Basilicata, Sonia Orellana, Maria Orellana, Aaliyah Salmon, Joanna Syska, Aravis Mcbroom, Jian Wang, Anam Riaz, Jody-Ann Douglas

Publications and Research

Radiology departments have contributed significantly to greenhouse gases including release of toxic imaging contrast media to environment. We feel Radiology also has several spectroscopy and imaging tools that may apply to monitor and support cleaner environmental goals. The current manuscript is one of the firsts to prompt Radiology to move in that direction by non-invasive imaging of bio metals that are less abundant in biological tissues but play key roles as co-factors in tissue structure and function. Conventional analytical tools are mostly invasive and cannot characterize the native oxidation states of bio metals. We chose carbohydrate matrix of metal-rich fruits …

How Do Higher Education Administrators And Leaders Perceive Academic Persistence And Achievement Of Afro Caribbean Immigrant Students?, Rory T. Richards

Publications and Research

This research looked at Higher Education Leaders’ Perceptions of Persistence and Achievement of Afro Caribbean Immigrant Students. The research was qualitative and took a phenomenological, narrative approach. Sixteen administrators, across three campuses, one private for-profit and two public nonprofits were interviewed. The participants consisted of one President, one Senior Vice President, three Vice Presidents, one Assistant Vice President, three Deans, two Assistant Deans, two Directors, one Department Chair, and one Special Assistant to the President. The participants were also multiethnic, comprising eight Black leaders, five white leaders, two Latino leaders, and one Asian leader. The research found that leaders at …

Immune Checkpoint Inhibitors: Friend Or Foe, Antonio Cordova, Md, Jesse Powell, Md, Whitney Elg-Salsman, Md, Caroline Mcculley, Md

Poster Presentations

No abstract provided.

A Gis Look At Woody Plant Encroachment (Wpe): Mapping Grassland Degradation Through Habitat Succession, Brandon M. Wolf

Geography and the Environment: Graduate Student Capstones

The grasslands of North America remain at a fraction of their historic range. Estimates of acreage remaining vary between 4% and 13%. Affectionately known as the Great Plains, these grasslands have been converted for agriculture, rangeland, infrastructure, and civilization itself. Woody Plant Encroachment (WPE) on the grasslands is a silent, often overlooked, serious threat. The use of a simple GIS can estimate current acreage of a grassland, its adjacent woodland corridor, riparian buffers, and predict future acreage based on trends and hypothetical management scenarios, or lack thereof. The American prairie, though a remnant of its former self, is still home …

Data-Driven Biomedicine Investigation Of Genetic And Infectious-Based Diseases Using Omics Data And Data Science Methodologies., Diing De Mapior Agany

Dissertations and Theses

The binary model of existence consists of health and disease, with health being complete physical, mental, and social well-being and disease being a pathological process. Humanity has been plagued by genetic and infectious diseases since civilization's dawn. These diseases cause changes in this model at the system biology level. Omics technologies, data science methodologies, and big data are being used to study these changes at the molecular level, leveraging biological processes' interconnectedness. Also, advanced computational methodologies are essential for efficient analytics and actionable discovery. In this dissertation, genetic and infectious-based diseases are investigated using omics data and data science methods …

A Year At The Forefront Of Bacterial Defense Systems Against Neutrophilic Oxidants, Sadia Sultana, Jan-Ulrik Dahl

Faculty Publications – Biological Sciences

One challenge for invading pathogens represents the exposure to highly microbicidal hypohalous acids (HOX), such as hypochlorous acid (HOCl) and hypothiocyanous acid (HOSCN). Generated at high concentrations by innate immune cells during phagocytosis, HOX kills the engulfed microbes through extensive macromolecular damage. However, microorganisms have evolved strategies to detoxify the oxidants and/or alleviate HOX-mediated damage, which improves their survival during HOX exposure. Many of these defense systems are bacteria-specific and therefore considered potential drug targets. Our minireview highlights recent (July 2021 to November 2022) advances in the field of microbial HOX defense systems and how these systems are regulated. We …

Biocybersecurity And Deterrence: Hypothetical Rwandan Considerations, Issah Samori, Gbadebo Odularu, Lucas Potter, Xavier-Lewis Palmer

Community & Environmental Health Faculty Publications

Digitalization and sustainability are popular words within modern disciplines as practitioners each look toward the future of their respective fields. Specifically for the African continent, which is making great strides in developmental targets, those two terms are central to core aspects of policy initiatives that may foster cooperation across its varied lands and nations. One of the underlying challenges that confront Africa is a lack of strong regional integration across socioeconomic and political programs; there is value in African regions having more regional connectedness. We assess the rate of regional integration and development in Africa and discuss how to alleviate …

A Relationship Between Personality Traits And Internet Addiction In A Sample Of Albanian University Students, Desara Celiku

Selected Full-Text Master Theses 2021-

The internet is one of the most important inventions that has brought the world together. It has changed the way we live, the way we work, and the way we learn. The internet takes a major part of our time, and research has shown that people struggle to find the balance between being online or offline. When this escalates to the level of addiction, we have a major problem. Even though this is now a worrying problem, just a few investigations have been made into understanding the relationship between internet addiction and its potential risk factors. This study aims to …

Characterization Of The Mycobiome Of Rafflesia Seeds: Their Potential Ecological Roles And Applications In Rafflesia Propagation And Conservation, Feruza Karnitskiy

Selected Full-Text Master Theses 2021-

The plant microbiome exerts a profound influence on plant health, growth, and life cycle. This ecosystem comprises diverse microbial communities, such as symbiotic endophytes, mycorrhizal fungi, epiphytes, saprophytes, rhizobia, and pathogens, which inhabit parasitic and non-parasitic plants. Rafflesia speciosa, a holoparasitic plant, is a unique and endangered species that depends on its host Tetrastigma spp. for survival. In this study, fungal metagenomics was conducted to characterize the fungal community—the mycobiome within Rafflesia seeds, and a phylogeny was reconstructed. The ecophysiological characteristics of these fungal genera were also researched in the literature, and their primary ecological trait, whether plant mutualist, saprotroph, …

The Connection Between Cptsd And Eating Disorders, Penelope Triantafyllou

Selected Full-Text Master Theses 2021-

Eating Disorders (EDs) are serious mental health conditions proposed to be multifactorial in nature. Post-traumatic stress disorder (PTSD), trauma history, and childhood maltreatment have been noted as possible predictive factors for their development. Research on complex posttraumatic stress disorder (CPTSD) in relation to EDs, however, is limited. The present study aimed to assess the relationship between childhood maltreatment and ED psychopathology, in relation to CPTSD symptomatology as defined by the ICD-11. Relationships between ED symptomatology and the trauma responses associated with the stress or “fight-or-flight” response were analyzed. 167 female participants, aged 18-25, who reported having experienced at least one …

January 2023 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Promoting Well-Being Among Intercollegiate Student-Athletes: A Gratitude Intervention Using Positive Psychology, Laura Kruger

Dissertations and Theses

Intercollegiate student-athletes face rising stress and pressures which challenge their well-being and mental health, and sometimes with alarming concerns. Over the years, supportive services and resources specifically available to student-athletes have not evolved at the same pace as student-athlete needs. Also, barriers and stigmas hinder student-athletes from readily accessing supportive mental health services. The high stress of student-athletes can contribute to the development of negative mental health symptoms and impairs positive well-being. Evidence supports how outreach initiatives help student-athletes. Positive psychology, including gratitude as a positive psychological state, has shown benefits to well-being. This experimental study design researched if the …

Negotiating Scientific Identity And Agency: Graduate Student Perspectives On A Public Communication Of Science Course, Lillian Campbell

English Faculty Research and Publications

Drawing on interviews with nine graduate science students, this article explores perspectives on a Public Communication of Science (PCS) course designed to help students translate their research for a public talk given at a local town hall. I first outline the history of the student-run course and then discuss three course components—public rhetoric of science; improvisation; and audience awareness. Within each component, I describe one student’s particular experience with the course. I describe how students transferred rhetorical lessons from the course to their academic writing but could also transfer rigid views of communication from their scientific work back into their …

Research Model Applications In The Investigation Of Vascular Disease Treatments, Alex Anthony Dangler

Dissertations and Theses

Cardiovascular disease (CVD) is a pressing global health issue with significant socioeconomic consequences. Within the spectrum of CVDs, peripheral artery disease (PAD) and aortic disease necessitate the development of effective and safe treatments. To achieve this, various research models are employed to investigate molecular mechanisms of cells, understand cellular interactions in vascular diseases, assess biocompatibility, and test and evaluate medical devices. This dissertation examines research models and their applications in the advancement of treatments for vascular diseases. For the evaluation of liposome delivery systems in PAD, an ApoE-/- cellular mouse model was employed to investigate the cellular uptake of liposomes …

“It's Not Passion, It's Sheer Survival”: The Lived Experiences Of Clinical Psychology Graduate Students Of Color During The Years 2020-2022, Yodit Denu

Dissertations and Theses

2020 was rife with social and political changes across the globe, ranging from the COVID-19 global pandemic, Black Lives Matter Movements, the effects of climate changes, and the insurrection on Capitol Hill (Salo, 2020). A qualitative methodology was used to explore the lived experiences of doctoral clinical psychology students of color during the crises of 2020-2022. Clinical psychology graduate students must navigate their own stressors in life (personal and academic) while also providing clinical therapeutic services to others, making them vulnerable to stress (DeAngelis, 2002). Many graduate students must balance academic coursework, clinical training, research, and financial demands, on top …

Functionalizing Metal-Organic Super-Containers (Moscs) For Selective Anion Recognition, Hanying Li

Dissertations and Theses

Anions are ubiquitous in Nature and play critical roles in both chemistry and biology. Biologically important molecules like enzymes, DNA, and ATP (adenosine triphosphate) are either anionic or contain negatively charged regions. Inorganic anions such as Cl- and HCO3- play essential roles in various physiological, environmental, and technological processes. Compared to cations, anions have larger ionic radii and more diffuse charge distribution, resulting in weaker electrostatic interactions. Developing synthetic receptors for controlled anion recognition is vital but poses significant challenges. Recent decades have shown remarkable progress in anion recognition, yielding diverse synthetic receptors with promising binding abilities. However, traditional approaches …

Academic Advisors’ Perceptions, Knowledge, And Attitudes Toward Working With Students Experiencing Substance Use Concerns, Amy Orr

Dissertations and Theses

Academic advisors have played an essential role within higher education institutions. Not only did academic advisors assist students in selecting courses/scheduling, but advisors could also help address students' substance use concerns. These concerns could be a factor preventing students from graduating. Students with substance use concerns who did not receive adequate services were barred from reaching their full potential in life and academics, receiving lower grades, and suffering from higher dropout rates than other students. Thus, it was vital for advisors to have the skills to help students with substance use concerns or refer them for additional services. Intrusive advising …

Molecular Investigation Of Minor Genomic Populations And Biological Exposures In Human Health, Brandon Ned Johnson

Dissertations and Theses

The study of genetics has contributed to countless discoveries related to human health and disease. However, the complexities of human biology reside not only in the genome but also in the contributions from environmental exposures, as measured via the classical twin design. To understand the influence of biological exposures, I implemented study designs to explore both the health associations and propagation of foreign genetic material. Microchimerism has been studied for association with several clinical conditions, and I further investigated if male microchimerism could elucidate the etiology of Mayer-Rokitansky-Küster-Hauser syndrome. Prevalence of male microchimerism in women with no history of pregnancy …

Childhood Maltreatment And Suicidal Ideation: The Role Of Insecure Attachment, Alexithymia, And Negative Urgency., Surabhi Swaminath

Dissertations and Theses

Suicide is a significant cause of preventable death, especially among young adults. Survivors of childhood maltreatment are at heightened risk of experiencing suicidal ideation and following through on suicide-related thoughts. Insecure attachment, alexithymia, and impulsivity (negative urgency) are known risk factors for suicidal ideation. However, the combined role of these variables in association with suicidal ideation is not fully understood. The current study tested the role of insecure attachment, alexithymia, and negative urgency in the relationship between child maltreatment and ideation via a path model in young adults between 18 and 29 (N = 441). We hypothesized that maltreatment would …

The Victorian Crisis Of Faith: Uncertainty, Pessimism, Morality, And Monsters. A Look At Nineteenth-Century British Gothic Horror And The Unassailable Unknown, Jay Schroeder

Dissertations and Theses

This work investigates how Gothic narratives employed negative aesthetics, monstrous bodies, exploded meaning, and an unshakable mood of uncertainty to explore rising fears of dwindling morality and impending human doom during the long nineteenth century. Using Eugene Thacker’s cosmic pessimism, Sianne Ngai’s concept of tone, and Stephen Greenblatt’s theories of resonance and wonder, combined with monster theory, Gothic criticism, biological studies of fear, and nineteenth-century studies in medicine, science, and literature, I investigate how these texts constructed monstrous bodies to create an atmosphere of fear that reflected a culture of pessimism and a crisis of faith to contend, albeit unsuccessfully, …

Molecular Biofilm Inhibitors On Noble Metal Surfaces, Mahamadu Tiah Mahama

Dissertations and Theses

Biofilms are the state microorganisms on surfaces which negatively impact many of processes taking place on them. For example, most microbial infections are attributed to biofilm forma- tion, with bacteria in biofilms exhibiting an antibiotic resistance several orders of magnitude than planktonic bacteria. Therefore, developing antibiofilm agents and understanding their mechanism of inhibition is essential. Citrate functionalized gold nanoparticles are well known for their an- tibiofilm properties. Recently, hybrid bisphosphonate polyoxovanadate gold nanoparticles showed a great potential to inhibit both gram-negative and gram-positive bacteria biofilm formation. How- ever, it is unknown how this species interacts with the metal surface, its …

A Phenomenological Study: Examining Resilience In Native American Women Who Witnessed Domestic Violence In Childhood And Experienced Domestic Violence In Adulthood, Arial Swallow

Dissertations and Theses

Domestic violence has significant acute and long-lasting harmful effects on the well-being of women from all backgrounds with higher rates of psychological effects in ethnic minority populations. Native American women experience domestic violence at disproportionate rates and face unique barriers in overcoming challenges of healing from domestic violence. Even though the impact of domestic violence in children and adults is well-studied, research in rural and Native American populations is scarce. Women who have witnessed or experienced domestic violence in childhood have identified challenges and strengths and developed coping strategies to help them endure and adapt to surviving domestic violence in …

Growing Up Ghanaian: The Well-Being Of Ghanaian Children In The United States And Ghana, Akua Bemma Opoku

Dissertations and Theses

Children’s subjective well-being is a child’s judgment of their well-being. Subjective well- being can have positive and negative indicators. Positive indicators include but are not limited to safety, feeling happy, and feeling excited. Negative indicators include but are not limited to lack of safety, lack of confidence, and sadness. Children’s ethnic background and their relation to their ethnic background may influence their subjective well-being. Research focusing on ethnic identity and child well-being has found positive associations. Research has also found a relationship between the context of family, school, peers, religion, community, and ethnic identity. This comparative phenomenological study aimed to …