Digital Commons Network^™

Beauty And The Boss: The Role Of Conforming Pressures Of Physical Appearance On The Career Experiences Of Senior-Level Black Women Administrators In Higher Education, Uzoma Florence Obidike

All-Inclusive List of Electronic Theses and Dissertations

This qualitative study examined how the conforming pressures related to physical appearance influenced the career experiences of senior-level Black women administrators in higher education. Employing a phenomenological approach, the research utilized semi-structured interviews and document analysis to delve into the participants' lived experiences. The study involved seven participants who shared their narratives spanning from the early stages of their higher education careers to their current senior-level roles within institutions of higher education. The nine core themes were physical appearance influences, conforming pressures related to physical appearance, always overdressed, guidance from supervisors, intersectionality, impression management, mindset of physical appearance at the …

Rosalie Edge And The Modern Environmental Movement, Elizabeth Claire Coleman

Mahurin Honors College Capstone Experience/Thesis Projects

This thesis examines and follows the actions of an understudied activist in the environmentalist movement: Rosalie Edge. This thesis relies and encourages a combination of conservation, environmentalism, and historical women’s history in America. Rosalie Edge’s work as an environmentalist created a new and effective way for environmentalists to advocate for the environment around them. She created a pamphlet medium that invited scientists and other conservationists to publish writings and opinions that went against what the Audubon Society, the Biological Survey, and legislators were doing and publishing. The research for this project combines analysis from other professionals in the field with …

Graduate Catalogue 2023-2024, Seton Hall University

Graduate Catalogues

No abstract provided.

Investigating The Role Of Nf-Kb Inhibition On Müller Glia Proliferation Following Injury In The Zebrafish Retina, Danielle Baffa

Celebration of Scholarship 2023

No abstract provided.

Determination Of Taxonomic Placement Of Falsely-Branched Taxa In Soils Of San Nicolas Island And Reassessment Of The Tolypothrichaceae, Natalie Soliman

Celebration of Scholarship 2023

No abstract provided.

Modification Of Hyaluronic Acid To Enable Click Chemistry Photo-Crosslinking Of Hydrogels With Tailorable Degradation Profiles, Ciara Buckley

Articles

Hyaluronic acid (HA) is a naturally occurring mucopolysaccharide that, due to its inherent bioactivity and extracellular matrix-like structure, has the potential to be utilised extensively in tissue engineering. However, this glycosaminoglycan lacks the properties required for cellular adhesion and photo-crosslinking by UV light, which significantly hinders this polymers applicability. This research presents a method for modifying hyaluronic acid via thiolation and methacrylation to generate a novel photo-crosslinkable polymer with improved physicochemical properties, biocompatibility and the potential to customize biodegradability according to the ratio of monomers used. A decrease in stiffness proportional to increasing thiol concentration was observed when testing the …

Teloportwrapper: A New Tool For Understanding The Dynamic World Of Fungal Telomere Ends, Trey Stansfield

Mahurin Honors College Capstone Experience/Thesis Projects

Telomeres are repetitive DNA sequence motifs found at eukaryote chromosome ends. Telomeres help protect chromosome ends from DNA damage and promote chromosome stability. Chromosomes play important roles in aging, mutation, and cancer. Eukaryotic pathogens also use telomeres to mutate and manage virulence genes. In response to chromosome end breakage newly formed telomeres, called de novo telomeres, are formed to recreate the lost telomere and sub-telomeric regions.

Magnaporthe oryzae is a fungal pathogen which causes wheat blast, a deadly plant disease in wheat. Magnaporthe oryzae is also known for its highly variable sub-regions which show high amounts of induced variability due …

Evaluation Of Ionic Liquid Treatment As An Alternative To Chemical Fixation And Dehydration In The Preparation Of Biofilms For Scanning Electron Microscopy, Molly Shreve

Mahurin Honors College Capstone Experience/Thesis Projects

Scanning electron microscopes (SEM) give researchers the ability to observe very small features on biological specimens at the nanometer scale, which is a much higher resolution than what can be obtained with a light microscope. To be observed under SEM, unlike light microscopes, samples must be dry, conductive, and able to withstand electron bombardment. Preparation methods have been developed that work well for samples composed mainly of proteins and lipids, but these fail for samples that are predominantly carbohydrates, such as bacterial biofilms. When carbohydrates of these biofilms are dehydrated, they tend to shrink and collapse, and their normal hydrated …

2023-24 Uni Wrestling Media Guide, University Of Northern Iowa

Athletics Media Guides

Contents:

--- 2023-24 Schedule
--- Big 12 Conference
--- 2023 NCAA Championships
--- Head Coach Doug Schwab
--- Coaching Staff
--- 2022-23 Roster
--- 2022-23 Results
--- Career and Season Leaders
--- All-time Records
--- Lettermen

Byron’S Orientalism: A Complication Of The East-West Binary, Lucienne Quirk

Undergraduate Review

Poet Lord George Byron reached his peak of fame in the early nineteenth century for his stories about the Near East. Until recently, his work was considered to be insular to his time, merely reflecting the interests of his time. However, modern scholars have revived interest in Byron through the lens of Orientalism, seeing how his work reflects ways in which Westerners create and control notions of race and identity. This work assesses three of Byron’s poems covering the Near East, coupled with several primary historical documents detailing his and other British travelers’ ventures into the Ottoman Empire. Both of …

Well-Being In Graduate Health Professions Education: Exploration Of Programmatic Interventions, The Student Experience, And Students’ Support Preferences, Katherine Schultz

Graduate Research Theses & Dissertations

Healthcare provider well-being is a growing area of professional concern. Beyond the negative impacts on the clinicians’ health, stress, burnout, and other manifestations of decreased clinician well-being can directly affect the quality of patient care. Research suggests that well-being concerns begin in graduate health professions education programs, during which students undergo rigorous academic and clinical training for future careers as clinicians. The aim of this study was to explore programmatic interventions to promote well-being in graduate health professions education and the students’ experiences of well-being while enrolled in graduate health professions programs.

This study was conducted across three phases. Phase …

Can An Instrument Be Developed To Evaluate Trauma Intervention Programs?, Julie D. Hancock

All-Inclusive List of Electronic Theses and Dissertations

Trauma experiences impact countless individuals every day. Trauma neither favors nor discriminates against any segment of the population; it is an equal opportunity pillager, often striking with no warning. No one is immune to trauma experience and effects, but one population is especially vulnerable to the aftereffects of trauma: the adolescent population. At a stage of life comprised of rapid physical changes and brain growth, the effects of trauma can have overwhelming consequences. However, even with increased vulnerability, this population is often overlooked in the selection of trauma intervention programs and practices for schools. The purpose of this quantitative study …

Water Quality And The Landscape: Long-Term Monitoring Of Rapidly Developing Suburban Watersheds, William H. Mcdowell

NH Water Resources Research Center Scholarship

No abstract provided.

2023-2024 Nsu Undergraduate Student Catalog, Nova Southeastern University

Undergraduate Programs Course Catalogs

No abstract provided.

Investigating Novel Ispe Inhibitors Of The Mep Pathway In Mycobacterium, Seoung Ryoung Choi, Prabagaran Narayanasamy

Journal Articles: Pathology and Microbiology

In a recent effort to mitigate harm from human pathogens, many biosynthetic pathways have been extensively evaluated for their ability to inhibit pathogen growth and to determine drug targets. One of the important products/targets of such pathways is isopentenyl diphosphate. Isopentenyl diphosphate is the universal precursor of isoprenoids, which are essential for the normal functioning of microorganisms. In general, two biosynthetic pathways lead to the formation of isopentenyl diphosphate: (1) the mevalonate pathway in animals; and (2) the non-mevalonate or methylerythritol phosphate (MEP) in many bacteria, and some protozoa and plants. Because the MEP pathway is not found in mammalian …

Proteomic Identification Of Seasonally Expressed Proteins Contributing To Heart Function And The Avoidance Of Skeletal Muscle Disuse Atrophy In A Hibernating Mammal, Msr Abid, E. C. Bredahl, A. D. Clifton, H. Qiu, M. T. Andrews, J. W. Checco

School of Natural Resources: Faculty Publications

No abstract provided.

Artificial Intelligence & Creativity: A Manifesto For Collaboration, Florent Vinchon, Todd Lubart, Sabrina Bartolotta, Valentin Gironnay, Marion Botella, Samira Bourgeois-Bougrine, Jean-Marie Burkhardt, Nathalie Bonnardel, Giovanni Emanuele Corazza, Vlad Glăveanu, Michael Hanchett Hanson, Zorana Ivcevic, Maciej Karwowski, James C. Kaufman, Takeshi Okada, Roni Reiter-Palmon, Andrea Gaggioli

Department of Psychology: Faculty Publications

With the advent of artificial intelligence (AI), the field of creativity faces new opportunities and challenges. This manifesto explores several scenarios of human–machine collaboration on creative tasks and proposes “fundamental laws of generative AI” to reinforce the responsible and ethical use of AI in the creativity field. Four scenarios are proposed and discussed: “Co-Cre-AI-tion,” “Organic,” “Plagiarism 3.0,” and “Shut down,” each illustrating different possible futures based on the collaboration between humans and machines. In addition, we have incorporated an AI-generated manifesto that also highlights important themes, ranging from accessibility and ethics to cultural sensitivity. The fundamental laws proposed aim to …

Developing Virtual And Augmented Reality Applications For Science, Technology, Engineering And Math Education, Christopher L. Hemme, Rachel Carley, Arielle Norton, Moez Ghumman, Hannah Nguyen, Ryan Ivone, Jyothi Menon, Jie Shen, Matthew Bertin, Roberta King, Elizabeth Leibovitz, Roy Bergstrom, Bongsup P. Cho

Biomedical and Pharmaceutical Sciences Faculty Publications

The Rhode Island IDeA Network of Biomedical Research Excellence Molecular Informatics Core at the University of Rhode Island Information Technology Services Innovative Learning Technologies developed virtual and augmented reality applications to teach concepts in biomedical science, including pharmacology, medicinal chemistry, cell culture and nanotechnology. The apps were developed as full virtual reality/augmented reality and 3D gaming versions, which do not require virtual reality headsets. Development challenges included creating intuitive user interfaces, text-to-voice functionality, visualization of molecules and implementing complex science concepts. In-app quizzes are used to assess the user's understanding of topics, and user feedback was collected for several apps …

Full Issue, Spring 2023, In The Ords

In the Ords: CSUMB Literary Arts Journal

No abstract provided.

Acda: Implementation Of An Augmented Drug Synergy Prediction Algorithm., Sergii Domanskyi, Emily L Jocoy, Anuj Srivastava, Carol J Bult

Faculty Research 2023

Motivation: Drug synergy prediction is approached with machine learning techniques using molecular and pharmacological data. The published Cancer Drug Atlas (CDA) predicts a synergy outcome in cell-line models from drug target information, gene mutations and the models’ monotherapy drug sensitivity. We observed low performance of the CDA, 0.339, measured by Pearson correlation of predicted versus measured sensitivity on DrugComb datasets.

Results: We augmented the approach CDA by applying a random forest regression and optimization via cross-validation hyper-parameter tuning and named it Augmented CDA (ACDA). We benchmarked the ACDA’s performance, which is 68% higher than that of the CDA when trained …

Vitamin D Inhibits Osteosarcoma By Reprogramming Nonsense-Mediated Rna Decay And Snai2-Mediated Epithelial-To-Mesenchymal Transition., Enrico Capobianco, Vanessa Mcgaughey, Gerbenn Seraphin, John Heckel, Sandra Rieger, Thomas S Lisse

Faculty Research 2023

Osteosarcomas are immune-resistant and metastatic as a result of elevated nonsense-mediated RNA decay (NMD), reactive oxygen species (ROS), and epithelial-to-mesenchymal transition (EMT). Although vitamin D has anti- cancer effects, its effectiveness and mechanism of action against osteosarcomas are poorly understood. In this study, we assessed the impact of vitamin D and its receptor (VDR) on NMD-ROS-EMT signaling in in vitro and in vivo osteosarcoma animal models. Initiation of VDR signaling facilitated the enrichment of EMT pathway genes, after which 1,25(OH)2D, the active vitamin D derivative, inhibited the EMT pathway in osteosarcoma subtypes. The ligand- bound VDR directly downregulated the EMT …

Statistical Learning Methods To Identify Nonwear Periods From Accelerometer Data, Sahrej Randhawa, Manoj Sharma, Madalina Fiterau, Jorge A. Banda, Farish Haydel, Kristopher Kapphahn, Donna Matheson, Hyatt Moore Iv, Robyn L Ball, Clete Kushida, Scott Delp, Dennis P. Wall, Thomas Robinson, Manisha Desai

Faculty Research 2023

Background: Accelerometers are used to objectively measure movement in free-living individuals. Distinguishing nonwear from sleep and sedentary behavior is important to derive accurate measures of physical activity, sedentary behavior, and sleep. We applied statistical learning approaches to examine their promise in detecting nonwear time and compared the results with commonly used wear time (WT) algorithms. Methods: Fifteen children, aged 4–17, wore an ActiGraph wGT3X- BT monitor on their hip during overnight polysomnography. We applied Hidden Markov Models (HMM) and Gaussian Mixture Models (GMM) to classify states of nonwear and wear in triaxial acceleration data. Performance of methods was compared with …

Functional Analysis Of Collagen 17a1: A Genetic Modifier Of Junctional Epidermolysis Bullosa In Mice., Thomas J. Sproule, Robert Y Wilpan, Benjamin E. Low, Kathleen A Silva, Deepak Reyon, J Keith Joung, Michael V. Wiles, Derry C. Roopenian, John P Sundberg

Faculty Research 2023

Previous work strongly implicated Collagen 17a1 (Col17a1) as a potent genetic modifier of junctional epidermolysis bullosa (JEB) caused by a hypomorphic mutation (Lamc2jeb) in mice. The importance of the noncollagenous domain (NC4) of COLXVII was suggested by use of a congenic reduction approach that restricted the modifier effect to 2-3 neighboring amino acid changes in that domain. The current study utilizes TALEN and CRISPR/Cas9 induced amino acid replacements and in-frame indels nested to NC4 to further investigate the role of this and adjoining COLXVII domains both as modifiers and primary risk effectors. We confirm the importance of COLXVI AA 1275 …

Clathrin Light Chain-Conjugated Drug Delivery For Cancer., Sungwook Jung, Liwei Jiang, Jing Zhao, Leonard D. Shultz, Dale L Greiner, Munhyung Bae, Xiaofei Li, Farideh Ordikhani, Rui Kuai, John Joseph, Vivek Kasinath, David R Elmaleh, Reza Abdi

Faculty Research 2023

Targeted drug delivery systems hold the remarkable potential to improve the therapeutic index of anticancer medications markedly. Here, we report a targeted delivery platform for cancer treatment using clathrin light chain (CLC)-conjugated drugs. We conjugated CLC to paclitaxel (PTX) through a glutaric anhydride at high efficiency. Labeled CLCs localized to 4T1 tumors implanted in mice, and conjugation of PTX to CLC enhanced its delivery to these tumors. Treatment of three different mouse models of cancer-melanoma, breast cancer, and lung cancer-with CLC-PTX resulted in significant growth inhibition of both the primary tumor and metastatic lesions, as compared to treatment with free …

A Genome-Wide Crispr Activation Screen Identifies, Dinesh B Uthaya Kumar, Marina Yurieva, Jessica D S Grassmann, Lina Kozhaya, Caleb Dante Mcbride, Derya Unutmaz, Adam Williams

Faculty Research 2023

The genome is pervasively transcribed to produce a vast array of non-coding RNAs (ncRNAs). Long non-coding RNAs (lncRNAs) are transcripts of >200 nucleotides and are best known for their ability to regulate gene expression. Enhancer RNAs (eRNAs) are subclass of lncRNAs that are synthesized from enhancer regions and have also been shown to coordinate gene expression. The biological function and significance of most lncRNAs and eRNAs remain to be determined. Epithelial to mesenchymal transition (EMT) is a ubiquitous cellular process that occurs during cellular migration, homeostasis, fibrosis, and cancer-cell metastasis. EMT- transcription factors, such as SNAI1 induce a complex transcriptional …

Phenopacket-Tools: Building And Validating Ga4gh Phenopackets., Daniel Danis, Julius O B Jacobsen, Alex H Wagner, Tudor Groza, Martha A Beckwith, Lauren Rekerle, Leigh Carmody, Justin Reese, Harshad Hegde, Markus S Ladewig, Berthold Seitz, Monica Munoz-Torres, Nomi L Harris, Jordi Rambla, Michael Baudis, Christopher J Mungall, Melissa A Haendel, Peter N Robinson

Faculty Research 2023

The Global Alliance for Genomics and Health (GA4GH) is a standards-setting organization that is developing a suite of coordinated standards for genomics. The GA4GH Phenopacket Schema is a standard for sharing disease and phenotype information that characterizes an individual person or biosample. The Phenopacket Schema is flexible and can represent clinical data for any kind of human disease including rare disease, complex disease, and cancer. It also allows consortia or databases to apply additional constraints to ensure uniform data collection for specific goals. We present phenopacket-tools, an open-source Java library and command-line application for construction, conversion, and validation of phenopackets. …

Open Drug Discovery In Alzheimer's Disease., Alison D Axtman, Paul E Brennan, Tristan Frappier-Brinton, Ranjita Betarbet, Gregory W. Carter, Haian Fu, Opher Gileadi, Anna K Greenwood, Karina Leal, Frank M Longo, Lara M Mangravite, Aled M Edwards, Allan I Levey, The Emory-Sage-Sgc Treat-Ad Center.

Faculty Research 2023

Alzheimer's disease (AD) drug discovery has focused on a set of highly studied therapeutic hypotheses, with limited success. The heterogeneous nature of AD processes suggests that a more diverse, systems-integrated strategy may identify new therapeutic hypotheses. Although many target hypotheses have arisen from systems-level modeling of human disease, in practice and for many reasons, it has proven challenging to translate them into drug discovery pipelines. First, many hypotheses implicate protein targets and/or biological mechanisms that are under-studied, meaning there is a paucity of evidence to inform experimental strategies as well as high-quality reagents to perform them. Second, systems-level targets are …

Cry1 Expression During Postnatal Development Is Critical For The Establishment Of Normal Circadian Period, Aaron E Schirmer, Vivek Kumar, Andrew Schook, Eun Joo Song, Michael S Marshall, Joseph S Takahashi

Faculty Research 2023

The mammalian circadian system generates an approximate 24-h rhythm through a complex autoregulatory feedback loop. Four genes, Period1 (Per1), Period2 (Per2), Cryptochrome1 (Cry1), and Cryptochrome2 (Cry2), regulate the negative feedback within this loop. Although these proteins have distinct roles within the core circadian mechanism, their individual functions are poorly understood. Here, we used a tetracycline trans-activator system (tTA) to examine the role of transcriptional oscillations in Cry1 and Cry2 in the persistence of circadian activity rhythms. We demonstrate that rhythmic Cry1 expression is an important regulator of circadian period. We then define a critical period from birth to postnatal day …

Bridging The Rodent To Human Translational Gap: Marmosets As Model Systems For The Study Of Alzheimer's Disease., Stacey J Sukoff Rizzo, Gregg Homanics, David J Schaeffer, Lauren Schaeffer, Jung Eun Park, Julia Oluoch, Tingting Zhang, Annat Haber, Nicholas T Seyfried, Benedict Paten, Anna Greenwood, Takeshi Murai, Sang Ho Choi, Hasi Huhe, Julia Kofler, Peter L Strick, Gregory W. Carter, Afonso C Silva

Faculty Research 2023

INTRODUCTION: Our limited understanding of the mechanisms that trigger the emergence of Alzheimer's disease (AD) has contributed to the lack of interventions that stop, prevent, or fully treat this disease. We believe that the development of a non-human primate model of AD will be an essential step toward overcoming limitations of other model systems and is crucial for investigating primate-specific mechanisms underlying the cellular and molecular root causes of the pathogenesis and progression of AD.

METHODS: A new consortium has been established with funding support from the National Institute on Aging aimed at the generation, characterization, and validation of Marmosets …

Alterations In C:N Ratio To Understand Plant Metabolic Pathways In Response To Pressure From Goat Grazing In The Invasive Species: Rhamnus Cathartica, Vivian Marchan

Ignite the Spark Outstanding Undergraduate Research and Scholarship

The high fecundity and high germination rates of Rhamus cathartica serves the species to out-compete regional plant native species. Its high abundance in deciduous forest ecosystems forces species that are unable to utilize R. cathartica as a food source to migrate to areas of lower density, further contributing to the decline in regional biodiversity. Bare soil conditions left as the result of the high concentration of Nitrogen in senesced leaves and leaf litter, cause further amplification of the migration of non-plant species to areas of lower R. cathartica density. Nitrogen is essential to primary and secondary metabolism, thus minimizing the …