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2023

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Gnosticism, Political Theory And Apocalypse: Jacob Taubes And Günther Anders, Tracy Strong And Carl Schmitt, Babette Babich Jan 2023

Gnosticism, Political Theory And Apocalypse: Jacob Taubes And Günther Anders, Tracy Strong And Carl Schmitt, Babette Babich

Articles and Chapters in Academic Book Collections

Beginning with Jacob Taubes and Günther Anders on eschatology, apocalypse and political theology, including Saint Paul and Frankfurt School critical theory along with bombs and power plants (energy/climate), this essay parallels a re-reading of Tracy B. Strong’s political reading of Nietzsche on Jesus (and love) with Taubes, Anders and Carl Schmitt on politics (and technology). Highlighted throughout is the politically charged (and inherently esoteric) context of Gnosticism for philosophy and theory for Taubes but also for Anders.

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Screening The “Invisible Population” Of Older Adult Patients For Prescription Pain Reliever Non-Medical Use And Use Disorders, Alyssa M. Falise, Vinita Sharma, Carolin C. Hoeflich, Catalina Lopez-Quintero, Catherine W. Striley Jan 2023

Screening The “Invisible Population” Of Older Adult Patients For Prescription Pain Reliever Non-Medical Use And Use Disorders, Alyssa M. Falise, Vinita Sharma, Carolin C. Hoeflich, Catalina Lopez-Quintero, Catherine W. Striley

Public and Population Health Faculty Publications and Presentations

Background: In the United States, the number of older adults reporting non-medical use of prescription pain relievers (NMUPPR) between 2015 and 2019 has remained constant, while those meeting criteria for opioid use disorders (OUDs) between 2013 and 2018 increased three-fold. These rates are expected to increase due to increased life expectancy among this population coupled with higher rates of substance use. However, they have consistently lower screening rates for problematic prescription pain reliever use, compared to younger cohorts. Objectives: This commentary reviewed trends in older adult NMUPPR and OUDs and reviewed several available screening tools. We then considered …

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Inverting The Discourse Of Civilization And Barbarism In Mundo Del Fin Del Mundo And Un Viejo Que Leía Novelas De Amor By Luis Sepúlveda, Adrian Taylor Kane Jan 2023

Inverting The Discourse Of Civilization And Barbarism In Mundo Del Fin Del Mundo And Un Viejo Que Leía Novelas De Amor By Luis Sepúlveda, Adrian Taylor Kane

World Languages Faculty Publications and Presentations

American critic Raymond Leslie Williams has convincingly argued that a desire to be modern is a central characteristic of the 20th century Latin American novel. Williams's argument also coincides with Octavio Paz's assertion that modernity has been a topic of interest to Latin American intellectuals since the 19th century. A glimpse of the terminology used by authors and critics to name various Latin American movements over the past 125 years—modernismo, posmodernismo, avant-garde, modern novel, and postmodern fiction—gives us a sense of the persistent desire of Latin American authors to engage in a dialogue on …

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Dna Damage Response Activates The Electron Transport Chain And Oxidative Metabolism By Two Parallel Mechanisms, Shreya Nagar Jan 2023

Dna Damage Response Activates The Electron Transport Chain And Oxidative Metabolism By Two Parallel Mechanisms, Shreya Nagar

Theses and Dissertations

The DNA damage response (DDR) is an evolutionarily conserved process essential for cell survival. Major part of DDR is coordinated by DNA damage checkpoint (DDC). In addition to DDC, eukaryotic cells also have DNA replication checkpoint (DRC) that is distinct from the DDC and specifically signals slowly progressing or arrested replication forks. DDR involves stalling or arrest of the cell cycle, initiation of DNA repair, and altered regulation of transcription, translation, and the ubiquitin-proteasome system. DDR also triggers transcription shut-off of histone genes. One of the key outcomes of DDC/DRC activation is the increased synthesis of the deoxyribonucleoside triphosphates (dNTPs), …

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Chemical Disinfection In Rural Ecuador, Lachlan Beebe, Chad Tatko, Julie Wildschut Jan 2023

Chemical Disinfection In Rural Ecuador, Lachlan Beebe, Chad Tatko, Julie Wildschut

Summer Research

The Clean Water Institute, in conjunction with Calvin University seeks to address issues with water availability in developing countries, particularly as it relates to quality of the water. The research done this summer was to investigate the potential implementations of improvements for clean water in rural Ecuador. These improvements manifested themselves in two distinct initiatives: The first initiative was to investigate the implementation of a passive chlorinator in a small Ecuadorean community. This involved literature review to decide a chlorinator to pursue, followed by extensive testing to validate the efficacy of the chlorinator under a variety of conditions. The second …

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Native Plant Restoration On Calvin’S Campus And An Introduction To The Calvin Biodiversity Project, David Warners, William Hofmann Jan 2023

Native Plant Restoration On Calvin’S Campus And An Introduction To The Calvin Biodiversity Project, David Warners, William Hofmann

Summer Research

Since university campuses serve as important education and public gathering centers for the cities and towns in which they reside, it is critical to maintain pleasing aesthetics that are cost effective while also promoting sustainability and biodiversity enhancement. On Calvin’s campus, many sites, including garden beds, restored woodlots, and even a dune provide these services. Native plants have continually been added to various locations around campus in place of lawn grass, with the goal of benefitting pollinators and birds along with creating natural sponges for stormwater runoff coming from parking lots and building roofs. These spaces also sequester carbon and …

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Temperature Effects On Conductivity Of Phospholipid Bilayers, Dylan Mount, Sebastian Grabill, Loren Haarsma Jan 2023

Temperature Effects On Conductivity Of Phospholipid Bilayers, Dylan Mount, Sebastian Grabill, Loren Haarsma

Summer Research

Phospholipids molecules contain a fatty acid tail and a head made of a phosphate group (Fig.1) and serve as the building blocks of cellular membranes. The tails are hydrophobic, meaning they are weakly attracted to water, while the head group is hydrophilic, which is strongly attracted to water. Lipids in water will spontaneously form into bilayers with the tails towards the center (Fig.2) and the heads pointing towards the water on either side. This is how the lipid bilayers are formed to separate a cell's interior from exterior. Biological cells contain mixtures of many lipids and other molecules. In our …

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Using Art To Foster Creation Care And Advance Environmental Sustainability, Orion Wakeman, Dave Warners Jan 2023

Using Art To Foster Creation Care And Advance Environmental Sustainability, Orion Wakeman, Dave Warners

Summer Research

Calvin University is on land that drains into the Plaster Creek watershed, which is known as the most contaminated watershed in West Michigan. Plaster Creek Stewards (PCS) is a local watershed group at Calvin University that uses native plantings and curb-cut rain gardens to address human impact to the watershed, including ten areas on Calvin’s campus. The restored habitats and rain gardens are unique features that still perceived by many as a challenge to traditional aesthetics. I embrace the intersection of arts and sciences to provide PCS and Calvin University with visually compelling resources for the public to learn about …

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Duck Identification And Regulation Preferences Among Waterfowl Hunters: A Pre-Assessment Of The Tier Ii Bag Limit, M. P. Gruntarod, M. P. Vrtiska, R. J. Murano, M. J. Garrick, C. J. Chizinski Jan 2023

Duck Identification And Regulation Preferences Among Waterfowl Hunters: A Pre-Assessment Of The Tier Ii Bag Limit, M. P. Gruntarod, M. P. Vrtiska, R. J. Murano, M. J. Garrick, C. J. Chizinski

School of Natural Resources: Faculty Publications

No abstract provided.

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Winter Spring 2023, Nova Southeastern University Jan 2023

Winter Spring 2023, Nova Southeastern University

KPCOM SGA Rounds

No abstract provided.

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Molecular Regulation Of The Salicylic Acid Hormone Pathway In Plants Under Changing Environmental Conditions, Christina A. M. Rossi, Eric J. R. Marchetta, Jong Hum Kim, Christian Castroverde Jan 2023

Molecular Regulation Of The Salicylic Acid Hormone Pathway In Plants Under Changing Environmental Conditions, Christina A. M. Rossi, Eric J. R. Marchetta, Jong Hum Kim, Christian Castroverde

Biology Faculty Publications

Salicylic acid (SA) is a central plant hormone mediating immunity, growth, and development. Recently, studies have highlighted the sensitivity of the SA pathway to changing climatic factors and the plant microbiome. Here we summarize organizing principles and themes in the regulation of SA biosynthesis, signaling, and metabolism by changing abiotic/biotic environments, focusing on molecular nodes governing SA pathway vulnerability or resilience. We especially highlight advances in the thermosensitive mechanisms underpinning SA-mediated immunity, including differential regulation of key transcription factors (e.g., CAMTAs, CBP60g, SARD1, bHLH059), selective protein–protein interactions of the SA receptor NPR1, and dynamic phase separation of the recently identified …

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Mineral-Specific Issues In 3d Scanning And Printing For Digital Collections, Outreach And Display, Selby Hearth, Bronwen Densmore Jan 2023

Mineral-Specific Issues In 3d Scanning And Printing For Digital Collections, Outreach And Display, Selby Hearth, Bronwen Densmore

Geology Faculty Research and Scholarship

Three-dimensional (3D) scanning and 3D printing of natural history specimens presents interesting opportunities for informal and formal science education, as well as specimen preservation and display. Museum staff in several museums have begun scanning and making specimens available online. However, very few mineral specimens are available as scanned 3D objects, because minerals present unique challenges in scanning. Specifically, their variable surface reflection properties (“luster”) and surface complexities make them complicated specimens to reproduce. This paper examines the variables involved in 3D scanning and 3D printing mineral specimens, lays out criteria for ideal candidates, and presents workarounds to common problems. In …

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Working With Students From Low Socioeconomic Families: What Can School Counselors Do?, Rachel S. Bluhm Jan 2023

Working With Students From Low Socioeconomic Families: What Can School Counselors Do?, Rachel S. Bluhm

Counselor Education Capstones

Poverty and low socioeconomic status (SES) in America negatively affect students in elementary, middle, and high school as they are still developing. It is crucial that school counselors and other helping professionals are aware of how to best support these students so they can achieve their highest as social support has been shown to be a protective factor for low SES in school. It is essential that school counselors and other staff in schools have effective training surrounding poverty and that they recognize how their social class affects their views and beliefs surrounding poverty and analyze those beliefs and practices. …

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Synergistic Detrimental Effects Of Cigarette Smoke, Alcohol, And Sars-Cov-2 In Copd Bronchial Epithelial Cells, Abenaya Muralidharan, Christopher Bauer, Dawn M. Katafiasz, Heather M. Strah, Aleem Siddique, St. Patrick Reid, Kristina L. Bailey, Todd A. Wyatt Jan 2023

Synergistic Detrimental Effects Of Cigarette Smoke, Alcohol, And Sars-Cov-2 In Copd Bronchial Epithelial Cells, Abenaya Muralidharan, Christopher Bauer, Dawn M. Katafiasz, Heather M. Strah, Aleem Siddique, St. Patrick Reid, Kristina L. Bailey, Todd A. Wyatt

Journal Articles: Environmental, Agricultural & Occupational Health

Lung conditions such as COPD, as well as risk factors such as alcohol misuse and cigarette smoking, can exacerbate COVID-19 disease severity. Synergistically, these risk factors can have a significant impact on immunity against pathogens. Here, we studied the effect of a short exposure to alcohol and/or cigarette smoke extract (CSE) in vitro on acute SARS-CoV-2 infection of ciliated human bronchial epithelial cells (HBECs) collected from healthy and COPD donors. We observed an increase in viral titer in CSE- or alcohol-treated COPD HBECs compared to untreated COPD HBECs. Furthermore, we treated healthy HBECs accompanied by enhanced lactate dehydrogenase activity, indicating …

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Novel Analysis Of The Sars-Cov-2 Genome To Identify Positive Evolutionary Selection In The Spike Protein Of Emerging Variants, Ulysses Ison Jan 2023

Novel Analysis Of The Sars-Cov-2 Genome To Identify Positive Evolutionary Selection In The Spike Protein Of Emerging Variants, Ulysses Ison

Browse all Theses and Dissertations

This thesis tests the hypothesis that the spike protein of SARV-CoV-2 is under positive evolutionary selection. A consensus nucleotide sequence was generated for the most current SARS-CoV-2 variant, XBB1.5, by performing sequence alignments of recent isolates. The consensus nucleotide sequence was translated to obtain the amino acid sequence. The amino acid and nucleotide sequences were compared to the original Wuhan-hu-1 strain to identify mutations. Forty-three mutations were identified in the spike protein, and all but two changed the amino acid. The majority of mutations were found in the receptor binding domain of the spike protein, which is the region of …

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Lipin1 Overexpression Ameliorates The Dystrophic Phenotype In Mdx Mice By Enhancing Myofiber Membrane Integrity, Abdullah Alshudukhi Jan 2023

Lipin1 Overexpression Ameliorates The Dystrophic Phenotype In Mdx Mice By Enhancing Myofiber Membrane Integrity, Abdullah Alshudukhi

Browse all Theses and Dissertations

Duchenne muscular dystrophy (DMD) is a severe disease characterized by a progressive muscle fiber loss. DMD affects approximately 1 in 3500 male births worldwide. Patients die at early ages due to failure of respiratory and cardiac functions. DMD is caused by mutations in dystrophin gene. Loss of dystrophin leads to disruption of the membrane integrity and necroptosis in skeletal muscles of DMD patients contributing to muscle fiber loss. Currently, effective therapies for DMD have not been established. The goal of this project is to find mechanisms that may improve muscle function/structure despite dystrophin deficiency. Our data show that the expression …

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Unfolding The Link Between The Axon Initial Segment, Endoplasmic Reticulum Stress, And Cognitive Impairment In Type 2 Diabetes, Jennae Shelby Jan 2023

Unfolding The Link Between The Axon Initial Segment, Endoplasmic Reticulum Stress, And Cognitive Impairment In Type 2 Diabetes, Jennae Shelby

Browse all Theses and Dissertations

Dementia and mild cognitive impairment are well recognized comorbidities of type 2 diabetes, termed diabetic encephalopathy, that lack in course modifying treatment options. The axon initial segment (AIS) is a critical mediator of neuronal output. Shortening of AIS length has been shown to decrease neuronal excitability and is implicated in diabetic encephalopathy. AIS shortening may be reversible, hence investigating the mechanism responsible could address this significant gap in patient care by providing new therapeutic targets. Endoplasmic reticulum (ER) stress, a cellular condition that activates the unfolded protein response has been implicated in diabetic encephalopathy. Here, using immunocytochemistry in primary mouse …

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Cas Accents, Vol. 25, No. 2 (Anniversary Issue), College Of Arts And Sciences, University Of The Philippines Los Baños Jan 2023

Cas Accents, Vol. 25, No. 2 (Anniversary Issue), College Of Arts And Sciences, University Of The Philippines Los Baños

CAS Accents

No abstract provided.

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Cas Accents, Vol. 25, No. 1 (2023 Uplb Graduation Issue), College Of Arts And Sciences, University Of The Philippines Los Baños Jan 2023

Cas Accents, Vol. 25, No. 1 (2023 Uplb Graduation Issue), College Of Arts And Sciences, University Of The Philippines Los Baños

CAS Accents

No abstract provided.

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Prenatal Cannabinoid Exposure: Why Expecting Individuals Should Take A Pregnancy Pause From Using Cannabinoid Products, Alexis Lin, Gelonia L. Dent, Suzy Davies, Zarena M. Dominguez, Leigh-Anne Cioffredi, Gabrielle L. Mclemore, Jessie R. Maxwell Jan 2023

Prenatal Cannabinoid Exposure: Why Expecting Individuals Should Take A Pregnancy Pause From Using Cannabinoid Products, Alexis Lin, Gelonia L. Dent, Suzy Davies, Zarena M. Dominguez, Leigh-Anne Cioffredi, Gabrielle L. Mclemore, Jessie R. Maxwell

Pediatrics Research and Scholarship

Cannabinoid use in all populations is increasing as legalization across the United States continues. Concerningly, there is a lack of caution provided by medical providers to pregnant individuals as to the impact the use of cannabinoids could have on the developing fetus. Research continues in both the preclinical and clinical areas, and is severely needed, as the potency of delta-9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis, has increased dramatically since the initial studies were completed. Thus far, clinical studies raise compelling evidence for short term memory deficits, impulse control issues, and attention deficiencies following prenatal cannabinoid exposure (PCE). These …

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What Drives Opposition To Suicide? Two Exploratory Studies Of Normative Judgments, Justin F. Landy, Pritika Shah Jan 2023

What Drives Opposition To Suicide? Two Exploratory Studies Of Normative Judgments, Justin F. Landy, Pritika Shah

Faculty Articles

The act of suicide is commonly viewed as wrong in some sense, but it is not clear why this is. Based on past empirical research and philosophical theorizing, we test ten different explanations for why suicide is opposed on normative grounds. Using a within-subjects design, Study 1 showed that seven out of ten manipulations had significant effects on normative judgments of suicide: time left to live, lack of close social relationships, a history of prior immoral behavior, the manner in which the suicide is committed, painful, incurable medical issues, impulsive decision-making, and the actor’s own moral-religious background. However, in all …

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Enhancement Of Metal Nanostructure Deposition On Silicon Laser-Induced Periodic Surface Structures By Galvanic Replacement, Nicholas Simpson, Eric J. Broadhead, Addison Casto, Katharine M. Tibbetts Jan 2023

Enhancement Of Metal Nanostructure Deposition On Silicon Laser-Induced Periodic Surface Structures By Galvanic Replacement, Nicholas Simpson, Eric J. Broadhead, Addison Casto, Katharine M. Tibbetts

Chemistry Publications

We report a chemically motivated, single-step method to enhance metal deposition onto silicon laser-induced periodic surface structures (LIPSSs) using reactive laser ablation in liquid (RLAL). Galvanic replacement (GR) reactions were used in conjunction with RLAL (GR-RLAL) to promote the deposition of Au and Cu nanostructures onto a Si LIPSS. To increase the deposition of Au, sacrificial metals Cu, Fe, and Zn were used; Fe and Zn also enhanced the deposition of Cu. We show that the deposited metal content, surface morphology, and metal crystallite size can be tuned based on the difference in electrochemical potentials of the deposited and sacrificial …

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There's A Pill For That: The Supreme Court's Misguided Jurisprudence On Commercial Speech Under The First Amendment And Its Implications On Direct-To-Consumer Advertising Of Prescription Drugs, Benjamin Smith Jan 2023

There's A Pill For That: The Supreme Court's Misguided Jurisprudence On Commercial Speech Under The First Amendment And Its Implications On Direct-To-Consumer Advertising Of Prescription Drugs, Benjamin Smith

Annals of Health Law and Life Sciences

No abstract provided.

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Serving Two Masters: Conflicts Between Physician Employment Contracts And The Physician's Duty Of Care, Steven L. Hendler, M.D. Jan 2023

Serving Two Masters: Conflicts Between Physician Employment Contracts And The Physician's Duty Of Care, Steven L. Hendler, M.D.

Annals of Health Law and Life Sciences

No abstract provided.

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High Volume Multiplex Staining Of Mouse Model In Alzheimer’S Associated Disease Pathology, Chloe Embry Jan 2023

High Volume Multiplex Staining Of Mouse Model In Alzheimer’S Associated Disease Pathology, Chloe Embry

Lewis Honors College Thesis Collection

Although neurodegenerative diseases are often clinically distinct, they typically share common pathological markers. One of the most common causes of clinical dementia is Alzheimer’s disease (AD). Pathologically, AD is defined by the presence of intercellular tangles composed of hyperphosphorylated tau proteins and extracellular plaques made of abnormally cleaved amyloid-beta proteins. However recent genome-wide association studies have also found that many of the predispositions for AD are located on or near genes highly expressed in microglia. In the healthy CNS, microglia act as the brain’s immune system and are chiefly involved in neuronal support and maintaining homeostasis throughout the CNS. Typically, …

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Vaccine Distribution With Drones For Less Developed Countries: A Case Study In Vanuatu, Shakiba Enayati, James F. Campbell, Haitao Li Jan 2023

Vaccine Distribution With Drones For Less Developed Countries: A Case Study In Vanuatu, Shakiba Enayati, James F. Campbell, Haitao Li

Educator Preparation & Leadership Faculty Works

Drones (uncrewed aerial vehicles or UAVs) introduce new opportunities to improve vaccine distribution systems, particularly in regions with limited transportation infrastructure where maintaining the cold chain is challenging. This paper addresses the use of drones to deliver vaccines to hard-to-reach populations using a novel optimization model to strategically design a multimodal vaccine distribution network. The model is illustrated in a case study for distributing routine childhood vaccines in Vanuatu, a South Pacific island nation with limited transportation infrastructure. Our research incorporates multiple drone types, recharging of drones, a cold chain travel time limit, transshipment delays for switching transport modes, …

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Ua68/6 Newsletter, Wku Gender & Women's Studies Jan 2023

Ua68/6 Newsletter, Wku Gender & Women's Studies

WKU Administration Documents

Newsletter created by and about the WKU Gender & Women's Studies program.

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Ua51 Annual Report, Wku University Libraries Jan 2023

Ua51 Annual Report, Wku University Libraries

Library Annual Reports, Reports, and Statistics

WKU University Libraries annual report.

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The Cascading And Compounding Impacts Of Drought, 2023, K. H. Smith, Cody L. Knutson, Mark D. Svoboda Jan 2023

The Cascading And Compounding Impacts Of Drought, 2023, K. H. Smith, Cody L. Knutson, Mark D. Svoboda

School of Natural Resources: Faculty Publications

No abstract provided.

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Plant Community Response To Control Of A Dominant Invader At Multiple Scales, Alexander R. B. Goetz Jan 2023

Plant Community Response To Control Of A Dominant Invader At Multiple Scales, Alexander R. B. Goetz

Electronic Theses and Dissertations

Control of invasive Tamarix spp. in riparian systems has long been a priority for management in western North America, but questions remain regarding the response of the broader plant community to different treatments. Here we summarize a series of approaches at different scales to quantify the effects of Tamarix control on characteristics of this ecosystem, including provisioning of wildlife habitat. In the first chapter we analyzed findings of the last 20 years using meta-analysis and found that although treatment has been successful in reducing Tamarix and promoting native vegetation to some extent, most literature reports very small effect sizes and …

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