Digital Commons Network^™

2022 Technology Focus: Analysis And Interpretation Of 20 High-Impact Patented Technology Focus, Jiaofeng Pan, Weiwei Fan, Fuhai Leng, Guopeng Li, Feng Zhang, Lin Han, Haiming Wang, Chaoxing Zhang, Fan Yang, Xiaomei Wang, Haixia Wang, Jianxia Yuan, Ying Xing, Ting Chen

Bulletin of Chinese Academy of Sciences (Chinese Version)

2022 Technology Focus report developed by the Institutes of Science and Development, Chinese Academy of Sciences (CASISD), is based on the role of "Technology Focus" in the fields of information, energy, life and material manufacturing in the new technological revolution. We select and determine "20 High-impact Patented Technology Focus" from the 32 "Technology Focus" areas that are highlighted in the report. It briefly describes the basic meaning, technological innovation challenges, and the research path. Based on the distribution of comprehensive influence scores of patent data in "Technology Focus", it reveals the technical innovation points and the characteristics of the national …

Delivering Occupation-Based Practice In Stroke Rehabilitation Of Hospital Settings: Thai Occupational Therapists’ Experiences, Anuchart Kaunnil, Veerawat Sansri, Surachart Thongchoomsin, Kannika Permpoonputtana, Sutinun Juntorn, Kathryn Jarvis, Cristina Reyes Smith, Michael Palapal Sy, Jiranan Griffiths, Chutikorn Nopparat, Peeradech Thichanpiang

The Qualitative Report

Occupation-based practice (OBP) is central to the practice of occupational therapists where occupations or meaningful activities become the focus of the assessment, intervention, and outcomes measurement process. Although occupational therapists practising in Thailand claim that they engage in OBP, this claim warrants empirical investigation. This study aimed to investigate the experiences and perceptions of hospital-based occupational therapists of OBP within stroke rehabilitation. Utilizing a qualitative design, fourteen occupational therapists were recruited through purposive sampling. Data were collected through semi-structured interviews until data saturation was reached. Each interview was recorded and transcribed verbatim, and data were analyzed using thematic analysis. Five …

2023-01-20 Institutional Animal Care And Use Committee Meeting Minutes, Morehead State University. Faculty Senate., Institutional Animal Care And Use Committee.

Faculty Senate Records

Institutional Animal Care and Use Committee meeting minutes of January 20, 2023.

Fluorescence Angiography With Dual Fluorescence For The Early Detection And Longitudinal Quantitation Of Vascular Leakage In Retinopathy, Benjamin Pomeroy, Alexander W Venanzi, Wei Li, Abigail S Hackam, Midhat H Abdulreda

Faculty, Staff and Students Publications

BACKGROUND: Diabetic retinopathy (DR) afflicts more than 93 million people worldwide and is a leading cause of vision loss in working adults. While DR therapies are available, early DR development may go undetected without treatment due to the lack of sufficiently sensitive tools. Therefore, early detection is critically important to enable efficient treatment before progression to vision-threatening complications. A major clinical manifestation of early DR is retinal vascular leakage that may progress from diffuse to more localized focal leakage, leading to increased retinal thickness and diabetic macular edema (DME). In preclinical research, a hallmark of DR in mouse models is …

Svhound: Detection Of Regions That Harbor Yet Undetected Structural Variation, Luis F Paulin, Muthuswamy Raveendran, R Alan Harris, Jeffrey Rogers, Arndt Von Haeseler, Fritz J Sedlazeck

Faculty, Staff and Students Publications

BACKGROUND: Recent population studies are ever growing in number of samples to investigate the diversity of a population or species. These studies reveal new polymorphism that lead to important insights into the mechanisms of evolution, but are also important for the interpretation of these variations. Nevertheless, while the full catalog of variations across entire species remains unknown, we can predict which regions harbor additional not yet detected variations and investigate their properties, thereby enhancing the analysis for potentially missed variants.

RESULTS: To achieve this we developed SVhound ( https://github.com/lfpaulin/SVhound ), which based on a population level SVs dataset can predict …

Identifying Biomarkers Of Differential Chemotherapy Response In Tnbc Patient-Derived Xenografts With A Ctd/Wgcna Approach, Varduhi Petrosyan, Lacey E Dobrolecki, Lillian Thistlethwaite, Alaina N Lewis, Christina Sallas, Ramakrishnan R Srinivasan, Jonathan T Lei, Vladimir Kovacevic, Predrag Obradovic, Matthew J Ellis, C Kent Osborne, Mothaffar F Rimawi, Anne Pavlick, Maryam Nemati Shafaee, Heidi Dowst, Antrix Jain, Alexander B Saltzman, Anna Malovannaya, Elisabetta Marangoni, Alana L Welm, Bryan E Welm, Shunqiang Li, Gerburg M Wulf, Olmo Sonzogni, Chen Huang, Suhas Vasaikar, Susan G Hilsenbeck, Bing Zhang, Aleksandar Milosavljevic, Michael T Lewis

Faculty, Staff and Students Publications

Although systemic chemotherapy remains the standard of care for TNBC, even combination chemotherapy is often ineffective. The identification of biomarkers for differential chemotherapy response would allow for the selection of responsive patients, thus maximizing efficacy and minimizing toxicities. Here, we leverage TNBC PDXs to identify biomarkers of response. To demonstrate their ability to function as a preclinical cohort, PDXs were characterized using DNA sequencing, transcriptomics, and proteomics to show consistency with clinical samples. We then developed a network-based approach (CTD/WGCNA) to identify biomarkers of response to carboplatin (MSI1, TMSB15A, ARHGDIB, GGT1, SV2A, SEC14L2, SERPINI1, ADAMTS20, DGKQ) and docetaxel (c, MAGED4, …

Personalized Therapeutics For Katp-Dependent Pathologies, Colin G Nichols

2020-Current year OA Pubs

Ubiquitously expressed throughout the body, ATP-sensitive potassium (K

Synthetic Biology Design As A Paradigm Shift Toward Manufacturing Affordable Adeno-Associated Virus Gene Therapies, Logan Thrasher Collins, Selvarangan Ponnazhagan, David T Curiel

2020-Current year OA Pubs

Gene therapy has demonstrated enormous potential for changing how we combat disease. By directly engineering the genetic composition of cells, it provides a broad range of options for improving human health. Adeno-associated viruses (AAVs) represent a leading gene therapy vector and are expected to address a wide range of conditions in the coming decade. Three AAV therapies have already been approved by the FDA to treat Leber's congenital amaurosis, spinal muscular atrophy, and hemophilia B. Yet these therapies cost around $850,000, $2,100,000, and $3,500,000, respectively. Such prices limit the broad applicability of AAV gene therapy and make it inaccessible to …

Portals To Learning: Threshold Concepts In Art History Teaching And Learning, Rhonda L. Reymond

Art History Pedagogy & Practice

Threshold concepts are conceived of as portals to learning that open previously inaccessible ways of thinking. They encompass specific ideas within a discipline that must be mastered before the learner can progress. The process of identifying threshold concepts can reveal hidden or unacknowledged fundamental disciplinary beliefs and epistemology. Integrating a threshold concepts framework into the scholarship of teaching and learning in art history (SoTL-AH) can help faculty diagnose and anticipate when students are likely to encounter troublesome knowledge within an art history course. Distinguishing these thresholds can aid instructors in designing courses that prepare for specific stages that present conceptual …

Aircraft Energy Management: A Best Practice For Integrating Safety And Efficiency, Juan Merkt

National Training Aircraft Symposium (NTAS)

Aircraft Energy Management: A Best Practice for Integrating Safety and Efficiency

The airplane is the quintessential energy system, constantly transforming, transferring, distributing, storing, and exchanging various forms of energy as it moves through the air. By its very nature, flight warrants safe and efficient management of the airplane’s energy. Thus, poor aircraft energy management can lead to unsafe and/or inefficient operations. Unfortunately, energy principles associated with motion control and performance have not found their way into civilian flight training. As a result, energy management skills, founded on those guiding principles, are not adequately taught to new pilots. The energy-training gap …

Fla Stat 49.011

Civil Matter Files

No abstract provided.

National Development And The Sustainability Of Mining In The Atacama Desert, Chile, Dakota Soleil Osgood

Capstone Collection

As climate change continues to intensify on a global scale, efforts have been made to implement renewable energies and progressive technologies. These tools are critical in the shift towards a more sustainable practice, and yet analysis of localized impacts from the development of these mechanisms is inadequate. Chile has been and continues to be a leading country in mineral extraction, with an economic history founded in the mining industry. The establishment of mining in Chile as a progressive tool has aided the social and economic development of the nation. Consequences of mining extraction, however, include intensive environmental degradation, human rights …

Green Synthesis Of Copper Nanoparticles Using Strawberry Leaves And Study Of Properties, Anti-Cancer Action, And Activity Against Bacteria Isolated From Covid-19 Patients, Arshad Mahdi Hamad, Qanat Mahmood Atiyea, Duaa N. Abdul Hameed, Adil Hussein Dalaf

Karbala International Journal of Modern Science

Severe acute respiratory syndrome type 2 caused by coronavirus 2 is responsible for SARS that led to the emergence of coronavirus disease 2019 (COVID-19). Recent studies have demonstrated a high correlation between secondary bacterial infections and worse outcomes and death in COVID-19 patients. The extensive use of medicines during the last SARS-CoV epidemic led to an increase in the prevalence of multi-drug-resistant germs. Nanoparticles have important characteristics and applications in health, industry, and applied fields, etc. In medical fields, they curb and stop antibiotic-resistant diseases and pathogens. In this study, strawberry leaf extract was used to synthesize copper nanoparticles. The …

Medical School Watercooler Newsletter - January 19, 2023, Lindsey Lyle

Watercooler Newsletter

This is the January 19, 2023 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Researches publish novel findings that could improve management of prostate cancer
• Meet a Med Student: Grace Dunbar
• New members selected for gold humanism in medicine honor society

Trisomy 21 Induces Pericentrosomal Crowding Delaying Primary Ciliogenesis And Mouse Cerebellar Development., Cayla E Jewett, Bailey L Mccurdy, Eileen T O'Toole, Alexander J Stemm-Wolf, Katherine S Given, Carrie H Lin, Valerie Olsen, Whitney Martin, Laura G Reinholdt, Joaquín M Espinosa, Kelly D Sullivan, Wendy B Macklin, Rytis Prekeris, Chad G Pearson

Faculty Research 2023

Trisomy 21, the genetic cause of Down syndrome, disrupts primary cilia formation and function, in part through elevated Pericentrin, a centrosome protein encoded on chromosome 21. Yet how trisomy 21 and elevated Pericentrin disrupt cilia-related molecules and pathways, and the in vivo phenotypic relevance remain unclear. Utilizing ciliogenesis time course experiments combined with light microscopy and electron tomography, we reveal that chromosome 21 polyploidy elevates Pericentrin and microtubules away from the centrosome that corral MyosinVA and EHD1, delaying ciliary membrane delivery and mother centriole uncapping essential for ciliogenesis. If given enough time, trisomy 21 cells eventually ciliate, but these ciliated …

The Chanticleer, 2023-01-19, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

Paternal Origin Of Mongolic-Speaking Populations: A Review Of Studies From Recent Decades (1999–2019) And Their Implications For Multidisciplinary Research In The Future, Sharengaowa, Peng-Cheng Ma, Wen-Jiao Yang, Altangoo Ochirbat, Maxat Zhabagin, Na Sun, Yong-Mei Xie, Yong-Lan Li, Lan-Hai Wei

Human Biology Open Access Pre-Prints

The activities of Mongolic-speaking populations, a large group of people in eastern Eurasia, have important impact on the history of East Asia and other parts of Eurasia. Most previous genetic research of East Asian populations, including ancient DNA studies, have involved samples from Mongolic-speaking populations or their ancient relatives. Here, we summarized frequency data of paternal Y-chromosome haplogroups from all available literature about Mongolic-speaking populations from 1999 to 2019. Fourteen paternal components were identified and six of them were proposed as major and common components in ancestor groups of Mongolic-speaking populations. We thoroughly discussed the possible origin, migration patterns, and …

Essential Oils Composition And Biological Activity Of Chamaecyparis Obtusa, Chrysopogon Nigritanus And Lavandula Coronopifolia Grown Wild In Sudan, Loai M H Eltayeb, Sakina Yagi, Hanan M M Mohamed, Gokhan Zengin, Mohammad Ali Shariati, Maksim Rebezov, Abdullah Ibrahim Uba, Jose Manuel Lorenzo

College of Science & Mathematics Departmental Research

Generally, there are scant data about the constituents and eventually the biological activity of essential oils (EOs) from aromatic plants that grow naturally in Sudan. The present study aimed to determine the chemical composition, and antioxidant and enzyme inhibitory activities of EO extracted from the fruit of Chamaecyparis obtusa (Siebold and Zucc.) Endl. (family Cupressaceae), root of Chrysopogon nigritanus (Benth.) Veldkampis (family Poaceae) and aerial part of Lavandula coronopifolia Poir (family Lamiaceae). The fruit of C. obtusa contained only monoterpenes, mainly hydrogenated ones, with α-pinene (69.07%) as the major component. Oxygenated sesquiterpenes comprised the highest content of the C. nigritanus …

Usage Statistics: Project Counter R5 Dr_D1 Report Fy2022 - Database Search And Item Usage, Andrée J. Rathemacher

Technical Services Reports and Statistics

Project COUNTER R5 Report DR_D1 for the University of Rhode Island for the period from July 1, 2021 - June 30, 2022. The DR_D1 report is defined as "Database Search and Item Usage." This report presents an annual total only and only includes those platforms successfully configured for automated harvesting via SUSHI.

File for download is Excel spreadsheet generated by Alma Analytics.

Results:

Searches Automated - 316,771

Searches Federated - 52,533

Searches Regular - 768,218

Total Item Investigations - 930,171

Total Item Requests - 251,936

Investiture Ceremony- Inauguration Of Rhea F. Law, Tampa Campus, January 19, 2023, University Of South Florida

USF Graduation and Convocation Programs

Program for the investiture of the eighth President of the University of South Florida, Rhea F. Law

Adsorptive Properties And On-Demand Magnetic Response Of Lignin@Fe3o4 Nanoparticles At Castor Oil–Water Interfaces, Mohammad J. Hasan, Emily Westphal, Peng Chen, Abishek Saini, I-Wei Chu, Sarah J. Watzman, Esteban E. Ureña-Benavides, Erick S. Vasquez

Chemical and Materials Engineering Faculty Publications

Lignin@Fe3O4 nanoparticles adsorb at oil–water interfaces, form Pickering emulsions, induce on-demand magnetic responses to break emulsions, and can sequester oil from water. Lignin@Fe3O4 nanoparticles were prepared using a pH-induced precipitation method and were fully characterized. These were used to prepare Pickering emulsions with castor oil/Sudan red G dye and water at various oil/water volume ratios and nanoparticle concentrations. The stability and demulsification of the emulsions under different magnetic fields generated with permanent magnets (0–540 mT) were investigated using microscopy images and by visual inspection over time. The results showed that the Pickering emulsions were more stable at the castor oil/water …

Rna Sequence To Structure Analysis From Comprehensive Pairwise Mutagenesis Of Multiple Self-Cleaving Ribozymes, Jessica M. Roberts, James D. Beck, Tanner B. Pollock, Devin P. Bendixsen, Eric J. Hayden

Biology Faculty Publications and Presentations

Self-cleaving ribozymes are RNA molecules that catalyze the cleavage of their own phosphodiester backbones. These ribozymes are found in all domains of life and are also a tool for biotechnical and synthetic biology applications. Self-cleaving ribozymes are also an important model of sequence-to-function relationships for RNA because their small size simplifies synthesis of genetic variants and self-cleaving activity is an accessible readout of the functional consequence of the mutation. Here, we used a high-throughput experimental approach to determine the relative activity for every possible single and double mutant of five self-cleaving ribozymes. From this data, we comprehensively identified non-additive effects …

The Association Between Civic Engagement Via Participatory Art And Adolescents’ Self-Esteem And Self-Efficacy, Michaela Ann Hayes

Theses and Dissertations

Civic engagement refers to actions taken by individuals to address issues of public concern, which can come in many forms including engagement in art. Participation in these activities can have positive impacts on the individual, including improved mental and physical health, as well as on the community through increased appreciation for differences and acquisition of values such as tolerance. The Bioecological Model suggests that an individual's participation in civic activities is influenced by the various levels of their environment. These experiences may be particularly impactful for adolescents. Indeed, adolescents who participated in civic engagement activities have been found to have …

The Inbio Barcoding Initiative Database: Dna Barcodes Of Iberian Trichoptera, Documenting Biodiversity For Freshwater Biomonitoring In A Mediterranean Hotspot, Joana Pauperio, Luis Martin Gonzalez, Jesus Martinez, Marcos A. González, Filipa Ms Martins, Joana Veríssimo, Pamela Puppo, Joana Pinto, Cátia Chaves, Catarina J. Pinho, José Manuel Grosso-Silva, Lorenzo Quaglietta, Teresa Luísa L. Silva, Pedro Sousa, Paulo Celio Alves, Nuno Fonseca, Pedro Beja, Sónia Ferreira

Biological Sciences Faculty Research

Background

The Trichoptera are an important component of freshwater ecosystems. In the Iberian Peninsula, 380 taxa of caddisflies are known, with nearly 1/3 of the total species being endemic in the region. A reference collection of morphologically identified Trichoptera specimens, representing 142 Iberian taxa, was constructed. The InBIO Barcoding Initiative (IBI) Trichoptera 01 dataset contains records of 438 sequenced specimens. The species of this dataset correspond to about 37% of Iberian Trichoptera species diversity. Specimens were collected between 1975 and 2018 and are deposited in the IBI collection at the CIBIO (Research Center in Biodiversity and Genetic Resources, Portugal) or …

Susceptibility To Neurodegenerative Disorders: Insights From Paleogenomic Data, Draga Toncheva, Sena Karachanak-Yankova, Maria Marinova, Plamenka Borovska, Dimitar Serbezov

Human Biology Open Access Pre-Prints

Ancient human genome data that has accumulated in recent years can be employed to establish the spatiotemporal trajectories of genetic variants associated with human diseases. Such knowledge might illuminate if and how past adaptations impact contemporary human health and medicine. Scarcely any studies have yet been attempted to evaluate the genetic susceptibility to neurodegenerative disorders in ancient human communities. Using publicly available ancient human genome-wide data the present study evaluates the molecular predisposition to neurodegenerative disorders in ancient human communities. To this end we screened the ancient genome-wide data for the presence of variants unequivocally associated with neurodegenerative disorders in …

Usage Statistics: Project Counter R5 Tr_J1 Report Fy2022 - Journal Requests (Excluding Oa_Gold) By Title, Andrée J. Rathemacher

Technical Services Reports and Statistics

Project COUNTER R5 Report TR_J1 for the University of Rhode Island for the period from July 1, 2021 - June 30, 2022. The TR_J1 report is defined as "Journal Requests (Excluding OA_Gold)." This report presents an annual total only and only includes those platforms successfully configured for automated harvesting via SUSHI.

File for download is Excel spreadsheet generated by Alma Analytics.

Results:

Total Item Requests - 771,947

Unique Item Requests - 578,437

The Importance Of Occupational Health Service In The Era Of Vuca And The Dissemination Of Related Research Results, Muchtaruddin Mansyur

Occupational and Environmental Medicine Journal of Indonesia

Worldwide have been facing the era of dynamic life with the rapidly changing global situation for decades. This era is colored by volatility, uncertainty, complexity, and ambiguity (VUCA) situation that is aggravated by the COVID-19 pandemic. We have all experienced the VUCA situation with the COVID-19 Pandemic that has lasted over 2 years. The United Nations Development Programme (UNDP)1 report should be a common reference for dealing with situations that are not just uncertain but also called “uncertainty complexes”. So-called because its dimensions take on a new form that has never been seen before in human history. The complexity of …

A Work-Related Thyrotoxic Periodic Paralysis In A Worker Exposed To Heat Stress: A Case Report, Shanti Puji Lestari, Muchtaruddin Mansyur

Occupational and Environmental Medicine Journal of Indonesia

Thyrotoxic Periodic Paralysis (TPP) is an uncommon disorder, characterized by the triad of acute hypokalemia, muscle paralysis, and thyrotoxicosis. Attacks are typically transient, last hours to days, and may be triggered by many conditions, including exposure to heat stress in both indoor and outdoor activities. Indoor workers, especially those working around furnaces, ovens, smelters, and boilers, are at a higher heat stress risk, even higher risk if they have other individual factors such as obesity, dehydration, slower heat acclimation, consume certain medications and presence of underlying diseases. A 48-year-old man presented a sudden onset weakness in all four limbs, associated …

The Analysis Of Risk Factors Affecting The Proportion Of Standard Threshold Shift Among Manufacturing Workers, Firly Ratsmita, Muhammad Ilyas, Liem Jen Fuk, Dewi S. Soemarko, Levina Chandra

Occupational and Environmental Medicine Journal of Indonesia

Introduction. About 82% of cases of hearing loss due to employment occur in workers in the manufacturing sector. The prevalence of hearing loss has a permanent impact that can be detected by standard threshold shift (STS). The aim of the study was to determine the relationship between individual and occupational risk factors on the proportion of STS. Methods. The research was a cross-sectional study on employees with noise exposure. The independent variables include individual factors such as age, history of hypertension, history of diabetes mellitus, smoking, body mass index, and occupational factors such as the history of chemical exposures, working …

Could Hypertension In Radiographers Associated With Low Ionizing Radiation Exposure? An Evidence-Based Case Report, Rita I. Wijaya, Levina C Khoe, Muchtaruddin Mansyur

Occupational and Environmental Medicine Journal of Indonesia

Low-dose ionizing radiation exposure (