Digital Commons Network^™

Working Within Constraints: Managing African Savannas For Animal Production And Biodiversity, J. T. Du Toit

IGC Proceedings (1977-2023)

The mean density of livestock biomass on African rangelands now greatly exceeds that of indigenous large herbivores, although livestock cannot fully substitute for wildlife with respect to co-evolved ecosystem processes involving herbivory. The dominance of livestock in semi-arid rangelands is largely due to water provision, which uncouples livestock population dynamics from the rainfall-driven trajectories followed by indigenous ungulate species in wildlife areas. Ecological sustainability cannot be achieved with a few exotic species maintained at unprecedented biomass densities in savanna ecosystems, which are evolutionarily adapted for species-rich communities of ungulates of a wise range of sizes. Integrating wildlife and livestock in …

Diversity And Variation In Nutritive Value Of Plants Growing On 2 Saline Sites In Southwestern Australia, H. C. Norman, R. A. Dynes, D. G. Masters

IGC Proceedings (1977-2023)

In south-western Australia 10% or 1.8 million ha of the farmed area is affected by dryland salinity and a further 6 million ha are at risk of salinity (NLWRA, 2001). Animal production from saltbush (Atriplex spp.)-based pasture systems represents the most likely large-scale opportunity for productive use of saline land in the short to medium term. Feeding saltbush-based pastures as a maintenance feed during the prolonged autumn feed gap typical in Mediterranean-type climates maximises their economic value. The aim of this study was to explore the diversity and nutritive value of plants that typically persist in saltbush-based saltland pastures.

The Long Road To Developing Native Herbaceous Summer Forage Legume Ecotypes, J. P. Muir, T. J. Butler, W. R. Ocumpaugh

IGC Proceedings (1977-2023)

Only a handful of well-adapted herbaceous summer forage legumes are currently marketed for drier regions of North America and even fewer are true natives. There is a growing demand for native germplasm in the region as a new generation of landowner attempts to return grasslands to a semblance of their original species and diversity. The objective of this paper is to describe preliminary research results of a grasslands team collecting, studying and promulgating native leguminous germplasm in Texas.

Mortality Model For A Perennial Grass In Australian Semi-Arid Wooded Grasslands Grazed By Sheep, K. C. Hodgkinson, W. J. Muller

IGC Proceedings (1977-2023)

No abstract provided.

Selecting Grassland Species For Saline Environments, M. E. Rogers, A. D. Craig, T. D. Colmer, R. Munns, S. J. Hughes, P. M. Evans, P. G. H. Nichols, R. Snowball, D. Henry, J. Deretic, B. Dear, M. Ewing

IGC Proceedings (1977-2023)

In Australia, around 5.7 million hectares of agricultural land are currently affected by dryland salinity or at risk from shallow water tables and this figure is expected to increase over the next 50 years (LWRA, 2001). Most improved grassland species cannot tolerate the combined effects of salt and waterlogging and, therefore, the productivity of sown grasslands in salt-affected areas is low. However, there is potential to overcome the lack of suitably adapted fodder species by introducing new, salt and waterlogging-tolerant species and by diversifying the gene pool of proven species. Potential species include exotic, naturalised and native Australian grass, legumes, …

Grazing Animal Production Systems And Grazing Land Characteristics In A Semi-Arid Region Of Greece, I. Hadjigeorgiou, G. Economou, D. Lolis, N. Moustakas, G. Zervas

IGC Proceedings (1977-2023)

Rough grazing in Greece cover about 40% of the total land area, is publicly owned and managed extensively (Hadjigeorgiou et al., 2002). The Prefecture of Larisa is in the centre of Greece, and has 212,000 ha of rough grazing land, with a variable topography ranging from sea level up to 3,000 m a.s.l. This area is utilized by a total population of 135,000 LU (mainly sheep, goats and some suckler cows), which consumes annually an appreciable fraction of their total nutrient requirements from rough grazing.

The Productivity Of Coastal Meadows In Finland, R. Nevalainen, S. Jaakola, A. Huuskonen, J. Kiljala, E. Joki-Tokola

IGC Proceedings (1977-2023)

The coastal meadows of Finland have gained a new interest as a summer pasture for cattle. These habitats have great historical, aesthetic and biological value (Pessa & Anttila, 2000). Typical features of the coastal meadows are the varying vegetation zones and wet, sometimes waterlogged, soils. The meadows are important nesting and feeding habitats for many water birds. When grazing ceases, reeds, trees and shrubs take over and the area loses its openness. Lately the amount of grasslands and pastures has drastically declined all over Europe. In Finland, the area of semi-natural biotopes has decreased to 1% of what it had …

Grass And Forage Plant Improvement In The Tropics And Sub-Tropics, Liana Jank, C. B. Do Valle, Rosangela M. S. Resende

IGC Proceedings (1977-2023)

1. The majority of tropical and subtropical forage grass genera and/or species have not yet been collected, or need further collection to be representative of their natural distribution.
2. New biotechnological techniques will only result in the release of superior forage cultivars if supported by strong breeding programs.
3. More funding and investment in the formation of strong public research teams in forage conservation and improvement are needed to guarantee the sustainability of tropical and subtropical pasture-based livestock systems in the future.
4. The creation of a permanent international working group on tropical and subtropical forages is essential to assist the International Plant Genetic …

Focused On Pedagogy: Qr Grading Rubrics For Written Arguments, Ruby Daniels, Kathryn Appenzeller Knowles, Emily Naasz, Amanda Lindner

Numeracy

Institutional assessments of quantitative literacy/reasoning (QL/QR) have been extensively tested and reported in the literature. While appropriate for measuring student learning at the programmatic or institutional level, such instruments were not designed for classroom grading. After modifying a widely accepted institutional rubric designed to assess QR in written arguments, the current mixed method study tested the reliability of two QR analytic grading rubrics for written arguments and explored students’ reactions to the grading tools. Undergraduate students enrolled in a business course (N = 59) participated. A total of 415 QR artifacts from 40 students were assessed; an additional 19 …

The Beacon, January 20, 2023, Beacon Staff

The Beacon, 2022-2023

Unsung Heroes: Dr. Bob Hubbard; How MLK changed America forever; SZA makes killer return with newest album; Long-awaited sequel introduces new faces; Visiting professor impacts Music Department; Make some noise for Northwestern percussion; Students experienced extreme weather; Campus celebrates Martin Luther King, Jr.; 20 Students experience Urbana Mission Conference; An honored theatre professor; AI won't break the Internet (But It Will Try); The Overrated City of Paris, France; Raiders win NAIA National Championship; Junior Schany Starts Semester off Strong; NWC Raiders Demolish Hastings in Weekend Sweep; Exploring questions about identity; Twelve Japanese students welcomed to campus;

Horizontal Gene Transfer Of Antibiotic Resistance In Staphylococcus Aureus Biofilms, Elisa Mcrae, Ashley Ball, Brad Berges

Library/Life Sciences Undergraduate Poster Competition 2023

Staphylococcus aureus is known to acquire much antibiotic resistance (AR), though the mechanisms by which AR is conferred between bacteria is still unknown. Many theories propose that biofilms play a role in the sharing of genetic information between bacteria, or horizontal gene transfer (HGT 1,2 . However, studies have yet to confirm under what conditions HGT is most likely to occur, as well as when it is most efficient. Analyzing HGT will contribute to a fuller understanding of how antibiotic resistance is conferred and how to combat this issue in our society.

Fast Blue And Cholera Toxin-B Survival Guide For Alpha-Motoneurons Labeling: Less Is Better In Young B6sjl Mice, But More Is Better In Aged C57bl/J Mice, Hasan Farid, Weston B. Gleford, Lori L. Goss, Teresa L. Garrett, Sherif M. Elbasiouny

Neuroscience, Cell Biology & Physiology Faculty Publications

Fast Blue (FB) and Cholera Toxin-B (CTB) are two retrograde tracers extensively used to label alpha-motoneurons (α-MNs). The overall goals of the present study were to (1) assess the effectiveness of different FB and CTB protocols in labeling α-MNs, (2) compare the labeling quality of these tracers at standard concentrations reported in the literature (FB 2% and CTB 0.1%) versus lower concentrations to overcome tracer leakage, and (3) determine an optimal protocol for labeling α-MNs in young B6SJL and aged C57Bl/J mice (when axonal transport is disrupted by aging). Hindlimb muscles of young B6SJL and aged C57Bl/J mice were intramuscularly …

Depletion Of Hiv Reservoir By Activation Of Isr Signaling In Resting Cd4+T Cells, Dajiang Li, Lilly M. Wong, Yuyang Tang, Brigitte Allard, Katherine S. James, George R. Thompson, Satya Dandekar, Edward P. Browne, Qingsheng Li, Jeremy M. Simon, Nancie M. Archin, David M. Margolis, Guochun Jiang

School of Biological Sciences: Faculty Publications

HIV reservoirs are extremely stable and pose a tremendous challenge to clear HIV infection. Here, we demonstrate that activation of ISR/ATF4 signaling reverses HIV latency, which also selectively eliminates HIV+ cells in primary CD4⁺T cell model of latency without effect on HIV-negative CD⁴⁺T cells. The reduction of HIV+ cells is associated with apoptosis enhancement, but surprisingly is largely seen in HIV-infected cells in which gag-pol RNA transcripts are detected in HIV RNA-induced ATF4/IFIT signaling. In resting CD4⁺ (rCD4⁺) T cells isolated from people living with HIV on antiretroviral therapy, induction of ISR/ATF4 signaling …

Hydroxytyrosol Reduces Foam Cell Formation And Endothelial Inflammation Regulating The Pparγ/Lxrα/Abca1 Pathway., Sara Franceschelli, Federica De Cecco, Mirko Pesce, Patrizio Ripari, Maria Teresa Guagnano, Arturo Bravo Nuevo, Alfredo Grilli, Silvia Sancilio, Lorenza Speranza

PCOM Scholarly Works

Cholesterol accumulation in macrophages leads to the formation of foam cells and increases the risk of developing atherosclerosis. We have verified whether hydroxytyrosol (HT), a phenolic compound with anti-inflammatory and antioxidant properties, can reduce the cholesterol build up in THP-1 macrophage-derived foam cells. We have also investigated the potential mechanisms. Oil Red O staining and high-performance liquid chromatography (HPLC) assays were utilized to detect cellular lipid accumulation and cholesterol content, respectively, in THP-1 macrophages foam cells treated with HT. The impact of HT on cholesterol metabolism-related molecules (SR-A1, CD36, LOX-1, ABCA1, ABCG1, PPARγ and LRX-α) in foam cells was assessed …

Evaluating Connectivity Of Coastal Marine Habitats In The Gulf Of Maine By Integrating Passive Acoustics And Metabarcoding, Grant Milne, Jennifer L. Miksis-Olds, Alyssa Stasse, Bo-Young Lee, Dylan C. Wilford, Bonnie Brown

Center for Coastal and Ocean Mapping

No abstract provided.

Genomes Of Endangered Great Hammerhead And Shortfin Mako Sharks Reveal Historic Population Declines And High Levels Of Inbreeding In Great Hammerhead, Michael J. Stanhope, Kristina M. Ceres, Qi Sun, Minghui Wang, Jordan D. Zehr, Nicholas J. Marra, Aryn P. Wilder, Cheng Zou, Andrea M. Bernard, Paulina D. Pavinski Bitar, Mitchell G. Lokey, Mahmood Shivji

Biology Faculty Articles

Despite increasing threats of extinction to Elasmobranchii (sharks and rays), whole genome-based conservation insights are lacking. Here, we present chromosome-level genome assemblies for the Critically Endangered great hammerhead (Sphyrna mokarran) and the Endangered shortfin mako (Isurus oxyrinchus) sharks, with genetic diversity and historical demographic comparisons to other shark species. The great hammerhead exhibited low genetic variation, with 8.7% of the 2.77 Gbp genome in runs of homozygosity (ROH) > 1 Mbp and 74.4% in ROH >100 kbp. The 4.98 Gbp shortfin mako genome had considerably greater diversity and 1 Mbp. Both these sharks experienced precipitous declines in …

Personalized Matched Targeted Therapy In Advanced Pancreatic Cancer: A Pilot Cohort Analysis, Justin Shaya, Shumei Kato, Jacob J. Adashek, Hitendra Patel, Paul T. Fanta, Gregory P. Botta, Jason K. Sicklick, Razelle Kurzrock

School of Veterinary and Biomedical Sciences: Faculty Publications

Despite progress, 2-year pancreatic cancer survival remains dismal. We evaluated a biomarker-driven, combination/N-of-one strategy in 18 patients (advanced/metastatic pancreatic cancer) (from Molecular Tumor Board). Targeted agents administered/ patient = 2.5 (median) (range, 1–4); first-line therapy (N = 5); second line, (N = 13). Comparing patients (high versus low degrees of matching) (matching score ≥50% versus <50%; reflecting number of alterations matched to targeted agents divided by number of pathogenic alterations), survival was significantly longer (hazard ratio [HR] 0.24 (95% confidence interval [CI], 0.078–0.76, P = 0.016); clinical benefit rates (CBR) (stable disease ≥6 months/partial/complete response) trended higher (45.5 vs 0.0%, P = 0.10); progression-free survival, HR, 95% CI, 0.36 (0.12–1.10) (p = 0.075). First versus ≥2nd-line therapy had higher CBRs (80.0 vs 7.7%, P = …

Biomechanically-Consistent Skin Stretch As An Intuitive Mechanism For Sensory Feedback: A Preliminary Investigation In The Lower Limb, Jenny A. Kent

Physical Therapy Faculty Research

The proprioceptive loss accompanied by lower limb amputation can impair function and mobility. We explore a simple, mechanical skin-stretch array configured to generate superficial tissue behaviour that might occur with movement about an intact joint. Four adhesive pads attached around the circumference of the lower leg were connected via cords to a remote “foot” mounted on a ball joint attached to the underside of a fracture boot, such that “foot” reorientation would result in skin stretch. In two discrimination experiments performed with and without the connection, with no view of the mechanism, and with minimal training, unimpaired adults (i) estimated …

Synthesize Heterogeneous Biological Knowledge Via Representation Learning For Alzheimer’S Disease Drug Repurposing, Kang-Lin Hsieh, German Plascencia-Villa, Ko-Hong Lin, George Perry, Xiaoqian Jiang, Yejin Kim

Faculty, Staff and Student Publications

Developing drugs for treating Alzheimer's disease has been extremely challenging and costly due to limited knowledge of underlying mechanisms and therapeutic targets. To address the challenge in AD drug development, we developed a multi-task deep learning pipeline that learns biological interactions and AD risk genes, then utilizes multi-level evidence on drug efficacy to identify repurposable drug candidates. Using the embedding derived from the model, we ranked drug candidates based on evidence from post-treatment transcriptomic patterns, efficacy in preclinical models, population-based treatment effects, and clinical trials. We mechanistically validated the top-ranked candidates in neuronal cells, identifying drug combinations with efficacy in …

Molecular Characteristics Of Periodontal Health: Collagens: Defining The Healthy Human Gingival Collagen Transcriptome, Christina Zachariadou, Thomas Hart, Deborah Hooper, Angelo Mariotti

School of Dentistry Faculty Publications

Background: Defining periodontal health has been an ambitious and complex goal. The numerous and varied definitions of what constitutes periodontal health have resulted in a collection of subjective and unreliable clinical findings to diagnose and classify periodontal health and disease. The aim of this study was to fundamentally delineate the molecular characteristics of healthy periodontal tissues in men and women as they age, using the most abundant connective tissue component: Collagens. Methods: Healthy gingival biopsies were separated into “young” (aged 18–35 years, five men/five women) and “old” (≥60 years, five men/four women) age groups depending on biological sex. RNA was …

Dietary Strawberries Improve Serum Metabolites Of Cardiometabolic Risks In Adults With Features Of The Metabolic Syndrome In A Randomized Controlled Crossover Trial, Arpita Basu, Kenneth Izuora, Andrew Hooyman, Hal R. Scofield, Jeffrey L. Ebersole

Physical Therapy Faculty Articles and Research

Dietary strawberries have been shown to improve cardiometabolic risks in multiple clinical trials. However, no studies have reported effects on serum metabolomic profiles that may identify the target pathways affected by strawberries as underlying mechanisms. We conducted a 14-week randomized, controlled crossover study in which participants with features of metabolic syndrome were assigned to one of the three arms for four weeks separated by a one-week washout period: control powder, 1 serving (low dose: 13 g strawberry powder/day), or 2.5 servings (high dose: 32 g strawberry powder/day). Blood samples, anthropometric measures, blood pressure, and dietary and physical activity data were …

Co-Culture Models Of Endothelial Cells, Macrophages, And Vascular Smooth Muscle Cells For The Study Of The Natural History Of Atherosclerosis, Martin Liu, Saurabhi Samant, Charu Hasini Vasa, Ryan M. Pedrigi, Usama Oguz, Sangjin Ryu, Timothy Wei, Daniel R. Anderson, Devandra K. Agrawal, Yiannis Chatzizisis

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Background

This work aims to present a fast, affordable, and reproducible three-cell co-culture system that could represent the different cellular mechanisms of atherosclerosis, extending from atherogenesis to pathological intimal thickening.

Methods and results

We built four culture models: (i) Culture model #1 (representing normal arterial intima), where human coronary artery endothelial cells were added on top of Matrigel-coated collagen type I matrix, (ii) Culture model #2 (representing atherogenesis), which demonstrated the subendothelial accumulation and oxidative modification of low-density lipoproteins (LDL), (iii) Culture model #3 (representing intimal xanthomas), which demonstrated the monocyte adhesion to the endothelial cell monolayer, transmigration into the …

Outcomes Of Surgical Treatment For Extradural Benign Primary Spinal Tumors In Patients Younger Than 25 Years: An Ambispective International Multicenter Study, Alexander C Disch, Stefano Boriani, Aron Lazary, Laurence D Rhines, Alessandro Luzzati, Ziya L Gokaslan, Charles G Fisher, Michael G Fehlings, Michelle J Clarke, Dean Chou, Nicole M Germscheid, Klaus-Dieter Schaser, Jeremy J Reynolds, The Ao Spine Knowledge Forum Tumor

Faculty, Staff and Student Publications

Extradural primary spinal tumors were retrospectively analyzed from a prospective database of 1495 cases. All subjects with benign primary tumors under the age of 25 years, who were enrolled between 1990 and 2012 (Median FU was 2.4 years), were identified. Patient- and case-related characteristics were collected and statistically analyzed. Results: 161 patients (66f;95m; age 17.0 ± 4.7 years at time of diagnosis) were identified. The most common tumors were osteoblastomas n = 53 (32.9%), osteoid osteomas n = 45 (28.0%), and aneurysmal bone cysts n = 32 (19.9%). The tumor grade, according to the Enneking Classification S1/S2/S3, was 14/73/74 (8.7/45.3/46.0%), …

Acquired Genomic Alterations On First-Line Chemotherapy With Cetuximab In Advanced Colorectal Cancer: Circulating Tumor Dna Analysis Of The Calgb/Swog-80405 Trial (Alliance), Kanwal Raghav, Fang-Shu Ou, Alan P Venook, Federico Innocenti, Ryan Sun, Heinz-Josef Lenz, Scott Kopetz

Faculty, Staff and Student Publications

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.Acquired genomic alterations (Acq-GAs), specifically RAS, BRAF, and EGFR-ectodomain mutations and ERBB2 and MET amplifications, are recognized as major mechanisms of resistance to later-line anti-EGFR-antibody therapy in metastatic colorectal cancer (mCRC). However, data regarding …

Resistance Mechanisms To Anti–Epidermal Growth Factor Receptor Therapy In Ras/Raf Wild-Type Colorectal Cancer Vary By Regimen And Line Of Therapy, Christine M Parseghian, Ryan Sun, Melanie Woods, Stefania Napolitano, Hey Min Lee, Jumanah Alshenaifi, Jason Willis, Shakayla Nunez, Kanwal P Raghav, Van K Morris, John P Shen, Madhulika Eluri, Alexey Sorokin, Preeti Kanikarla, Eduardo Vilar, Marko Rehn, Agnes Ang, Teresa Troiani, Scott Kopetz

Faculty, Staff and Student Publications

Purpose: Acquired resistance to anti-epidermal growth factor receptor (EGFR) inhibitor (EGFRi) therapy in colorectal cancer (CRC) has previously been explained by the model of acquiring new mutations in KRAS/NRAS/EGFR, among other MAPK-pathway members. However, this was primarily on the basis of single-agent EGFRi trials and little is known about the resistance mechanisms of EGFRi combined with effective cytotoxic chemotherapy in previously untreated patients.

Methods: We analyzed paired plasma samples from patients with RAS/BRAF/EGFR wild-type metastatic CRC enrolled in three large randomized trials evaluating EGFRi in the first line in combination with chemotherapy and as a single agent in third …

Examining The Release Of Synthetic Microfibres To The Environment Via Two Major Pathways: Atmospheric Deposition And Treated Wastewater Effluent, I. E. Napper, F. N.F. Parker-Jurd, S. L. Wright, R. C. Thompson

School of Biological and Marine Sciences

Research on the discharge of synthetic microfibres to aquatic environments has typically focused on laundering, where fibres can be discharged via wastewater effluent. However emerging research suggests that microfibres generated during the wear of textiles in normal use could present a major, additional, pathway for microfibre pollution to the environment. This study aimed to quantify and compare the quantities of microfibre entering the marine environment via both these pathways; wastewater discharge and atmospheric deposition. Areas of high and low population density were also evaluated. Samples were collected in and around two British cities (Bristol and Plymouth) both of which are …

Assessing The Effectiveness Of Integrated Multi-Trophic Aquaculture For Growing West Coast Venus Clams, Avery Wallace

Theses

With demand for sustainable sources of seafood on the rise, California is looking to expand aquaculture with a focus on innovative culturing methods and use of native or resident species. Therefore, this study examined the potential for culturing native North American west coast venus clams (Chione californiensis and Chione undatella) using integrated multi-trophic aquaculture (IMTA). An ITMA approach was chosen because it is a culture method that uses species from different but functionally complementary trophic levels that have been found to reduce the potential negative effects of traditional monoculture. California sea cucumber (Parastichopus californicus) and the seaweeds red ogo (Gracilaria …

Developing Ecological Security Pattern For Coastal Wetlands Based On “Three-Line Integration” Spatial Strategy, Xiaowen Li, Liehui Zhi, Tiantian Ma, Zengli Liu, Baoshan Cui, Dongdong Shao, Yu Cao, Yonglin Mu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Coastal wetlands function as key socioeconomic resources as well as ecological barriers for sustainable development in coastal regions. Although previous research and practices indicate that restoration of degraded wetlands needs combination with intact natural wetlands to achieve best integrated ecosystem services, this kind of integration is still lacking both in research and practice. In the past decades, increased land reclamation coupling with climate change (e.g. sea level rise) have led considerable coastal squeeze effects and intensified degradation and loss in coastal wetlands along Chinese coastline, restoration of damaged coastal wetlands is therefore urgently needed to enhance the overall ecological functions …

Development Opportunities And Technical Challenges Of Industrialization For Hydrogen Production From Bio-Ethanol Reforming, Xue Han, Hong He, Guojun Yue, Hailong Lin, Jinsong Liu, Bin Yu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Bio-ethanol reforming for hydrogen production, using renewable raw materials and adopting mature and efficient chemical processes, is an important source of green hydrogen supply to achieve the goals of carbon peaking and carbon neutrality. Bio-ethanol is a widely used substitute for fossil fuels. With the continuous progress of cellulosic ethanol technology in recent years, bio-ethanol will gradually break through the constraints of starch-based raw material supply. Based on the industrialization achievements of hydrogen production and bio-ethanol, bio-ethanol reforming can realize a rapid linkage with the existing hydrogen energy industry. However, the existence of a carbon-carbon signal bond in ethanol poses …

2022 Research Fronts: Development Trends And Key Research Questions In 11 Broad Research Areas, Jiaofeng Pan, Haixia Wang, Fuhai Leng, Feng Zhang, Fan Yang, Jianxia Yuan, Ying Xing, Weiwei Fan, Qiuju Zhou, Wenyue Bian, Chaoxing Zhang, Longguang Huang, Haiming Wang, Lin Han, Ruimin Pei

Bulletin of Chinese Academy of Sciences (Chinese Version)

In 2022, Institutes of Science and Development, Chinese Academy of Sciences (CASISD), the National Science Library, CAS, and Clarivate Analytics released their joint report Research Fronts 2022. The report utilized the Essential Science Indicators (ESI) database to do co-citation analysis. The 2022 report started from 12 610 research fronts in ESI and identified a total of 165 research fronts, including hot and emerging specialties spanning 11 broad research areas in sciences and social sciences. With the 165 research fronts and the related core papers and citing papers as the basis for analysis, this study summarized 8 development trends in science …