Digital Commons Network^™

Alternative Child Care Governance: The Kafala Family-Based Care Arrangement In Egypt, Heba El Azzazy

Theses and Dissertations

Over the past decade, Egypt has witnessed several changes in relation to its alternative care system for orphans and children without parental care. Starting 2014, the Egypt government along with Civil Society actors started to adopt the UN General Assembly guidelines on Alternative Care; which call on States to take solid actions to develop their respective deinstitutionalization strategy that aims towards the progressive elimination of institutional cares and prompting family-based care approaches for children deprived of parental care. According to the current situation, kafala is the main alternative family- based care option practiced in Egypt. Generally, there is very limited …

Cognitive Assessment Of Health-Care Workers Exposed To Ionizing Radiation And The Assessment Of Radiation Safety Awareness In Different Radiation Oncology Hospitals In Egypt, Basma M. Saleh

Theses and Dissertations

The increase in cancer cases and subsequent increase in chemotherapy and radiotherapy sparked worries over hospital workers' health and safety. There is a global trend towards routine assessment of awareness, safety measures, and radiation protection culture among healthcare workers. There is also a trend towards monitoring the various associations between radiation exposure and different health outcomes. In low- and middle-income countries, the use of advanced techniques and biomarker tests to track the health status of the workers is hard to achieve. This is due to the scarce resources and economic instabilities and that is why using a survey as a …

An Artificial Intelligence Tool For The Selection Of Delay Analysis Technique In Construction, Mostafa Farouk

Theses and Dissertations

The increasing complexity and magnitude of projects impose greater impact of delays on stakeholders. Construction delays are a major source of disputes in construction projects. Since a construction project depends on interactions and shared responsibilities among parties, research works were directed toward identifying delay causes, quantifying their impacts, and proposing ways to deal with them. Several delay analysis techniques (DATs) are available, but when applied to the same project’s delays provide different results. Thus, the selection of the DAT to use in evaluating delays becomes vital. Reviewing the literature, it has been realized that often there are disagreements, which lead …

Students’ And Teachers’ Perceptions Of Using Memes In Esl Classrooms, Fadwa Youssef

Theses and Dissertations

Using humor in the language classroom has proven to be an effective pedagogical teaching tool that builds rapport between students and teachers. It also reduces anxiety and affective filter as well as increases students’ performance and willingness to communicate in class using their L2 (Azizinezhad & Hashemi, 2011; Banks, 2014; Soares, 2015). Previous studies used humor broadly starting from humorous comments in class to funny TV shows, movies, or songs. Some studies went further using funny memes in class and fewer studies went all the way making students create memes as part of their class requirements (Purnama, 2017). Results of …

Differential Transcriptional Alterations In Detoxification Genes In Parkinson’S Disease In Egypt, Nourhan Shebl

Theses and Dissertations

PD is the most common motor neurodegenerative disease worldwide. The underlying cause of PD is still unknow, owingthis to the complexity of the disease. Often, genetics and environmental factors are collaborating in the initiation of the disease. Despite the diversity of its genetical and environmental profiles, the Egyptian population is one of the mostunderrepresented population in terms of PD research. In this study, we investigated PD through various perspectives tohighlight the complexity of the disease in Egypt, taking into consideration the diversity of the Egyptian population. We recruited PD patients and reference controls from 4 governorates: Cairo, Giza, Alexandria, and …

Carbon Dioxide Capture Potential Of Chitosan-Nanocrystalline Cellulose Aerogel Composite Materials: Synthesis, Functionalization, And Characterization, Victor Oghenekohwo

Theses and Dissertations

The carbon dioxide capture technology has been established as an invaluable player in the current global efforts to allay the warming of the planet and climate change. In this connection, the study centers on the valorization of waste organic materials for the application described herein. The sorbents, sourced from a combination of by-products of food processing and agricultural residue waste products, viz. seafood waste and sugarcane bagasse, showed prospects for selective carbon dioxide capture, adsorbing up to 5.78 mg/g of the gas at 273 K and 2.82 mg/g at 298 K, as observed on the Micromeritic ASAP 2020 surface area …

Waste-Derived Hybrid Nanocomposite For The Simultaneous Removal Of Antibiotics And Dyes From Water Bodies, Abdelkader Ahmed

Theses and Dissertations

A novel eco-friendly approach was used to synthesize a hydroxyapatite-carbon nanocomposite (HAP-C) by utilizing the industrial waste of cement kiln dust (CKD) as a source of calcium for the synthesis. Citric acid was first used to chelate the calcium from CKD, then the chelate was converted into a mixture of calcium carbonate and carbon by calcination at 450°C for 1 h. The mixture was used as a precursor for the synthesis of HAP-C by reacting it with ortho-phosphoric acid via a precipitation method. HAP-C was then calcined at different temperatures of 400, 500, and 700°C under inert atmosphere, with a …

Adsorption Of Antibiotics In Wastewater By Stevia Rebaudiana Zinc Oxide Nanoparticles, Hania Guirguis

Theses and Dissertations

Green zinc oxide nanoparticles (ZnO NPs), synthesized using Stevia rebaudiana extract, are investigated as novel adsorbents for the removal of the antibiotics ciprofloxacin (CIP) and tetracycline (TET) from water. The green ZnO NPs were synthesized using a novel, rapid and ecofriendly technique that utilized a natural source with high sugar content as a reducing agent and a less energy intensive approach that did not require annealing or calcination at high temperatures. The particles are mesoporous, with a hexagonal wurtzite structure, a BET surface area of 15.28 m2/g and a size range of 37.36-71.33 nm. At pH 5, the green ZnO …

Computational Identification Of Circulating Micrornas Associated With The Early Stage Of Ovarian Cancer, Ahmed Abdelrahman El Hosseiny

Theses and Dissertations

Background: Ovarian cancer is the leading cause of death among gynaecological malignancies. Its high fatality rate is due to the difficulty of early detection. Current screening methods are inadequate, and therefore, a new less-invasive early detection method is urgently needed. MicroRNAs are promising biomarker candidates for cancer detection, however, their potential for early detection use is understudied. Aim of the work: We sought to identify sensitive and selective microRNA markers for early diagnosis of ovarian cancer from blood serum samples through computational analysis. Methods: In this investigation, we used bioinformatic methods to analyze MicroRNA-Seq data obtained from public databases for …

Belas For The Prevention Of Child Marriage Among Sasak Community, West Lombok, Reni Kartikawati, Ni Nyoman Sri Natih, Sari Damar Ratri

Masyarakat: Jurnal Sosiologi

This paper aims to evaluate the compatibility of the belas mechanism, which separates prospective brides still considered children (merariq kodeq), in West Lombok Regency with the provisions of Child Protection Law No. 35/2014. While prior research in various countries has primarily focused on interventions and child marriage prevention programs, this study takes a different approach by examining the intricate relationship between children (those under 18 years of age) and the broader social system. To comprehensively explore this relationship, our team adopts Bronfenbrenner's socio-ecological model, which encompasses various stages of a child's life. This model considers individual biology, interactions …

Electrochemical Sensors And Biosensors Of Biomarkers And Therapeutic Agents Detection, Mahmoud Abdelhakem

Theses and Dissertations

Electrochemical sensing is a pioneering tool amongst all other sensing techniques even though it had been started in the early 20th century. Due to their cost efficacy, accuracy, and real-time measurement, electrochemical sensing has been utilized in a vast of biomedical applications in therapeutic drug monitoring and biomarker detection. This thesis work concerned the monitoring of three therapeutic agents in spiked plasma, urine, dosage form, and interstitial skin fluid with high specificity and accuracy. Two of our sensing platforms utilized nanomaterials for sensing (sensors) of Cilostazol and Velpatasvir utilizing α-MnO2-V2O5 (metal oxide nanorods) and NH2- MIL-53 (Aluminum-based metal organic frameworks), …

How Do The Environmental Aspects Affect The Oil Drilling And Extraction Sector? Evidence From Firm-Level Data, Nadine Amr Hosny

Theses and Dissertations

There will and always be a tradeoff between achieving profitability and maintaining sustainability. This complex problem is especially portrayed in the Oil sector. MENA region countries dominate more than half of the Oil reserves globally. Therefore and due to their dominance, such oil firms may suffer from several adverse consequences from their oil drilling and extraction activities. Accordingly, the main objective of the thesis is to examine the impact of the changes in environmental conditions on the financial performance of selected oil drilling and extraction firms. The selected countries that were chosen are: Egypt, Morocco, Tunisia & Gabon. The results …

Long-Standing Narrative Of Indonesian Islamic Women In Four Novels By Habiburrahman El Shirazy, Dian Rizky Azhari, M. Yoesoef, Turita Indah Setyani

International Review of Humanities Studies

Discussions about Islamic women have been buzzing in Indonesia after the collapse of the New Order. Its presence directly contradicts the narratives of women that were influenced by western thought, such as liberalism and secularism, as well as by global islamization movement from the Middle East. The conflicts that arose were about the role of women in the public sphere, women's independence, women's bodies and sexuality. This study aims to find similarities between ideas about Islamic women and the practice of Islamic women's discourse in Indonesian society. This study uses an intrinsic study method and a sociology of literature approach …

The Threat Of Covid-19 Pandemic In Social Network-Thinking, Poppy Setiawati Nurisnaeny, Rendy Ananta Prasetya, Suwedi Suwedi

International Review of Humanities Studies

The COVID-19 pandemic creates various dynamics of uncertainty that impact morbidity, mortality, and economic damage. The dynamics of these threats are expanding in the globalization era through networks and national security into a multidimensional sphere that tends to be unpredictable (Starvridis, 2015). Social transformation is always marked with certainties. Therefore, scientific regulations are needed to guide various operations, which functions as a principle in adapting to the quick-changing socio-cultural dynamics. This study aims to analyze the threat of the Covid-19 pandemic and strategic thinking steps in the ethnographic framework of social network thinking. This research uses a descriptive qualitative method …

Gendered Nollywood: The Crisis Of Femininity In Contemporary Nigerian Films, Abiodun Olayiwola

International Review of Humanities Studies

Studies on the construction of women in Nollywood films have majorly focused on the subjugation of women by the phallocentric African men and the need for socio-economic liberation. Most of these films perceive women as a socially constituted homogenous group on the basis of shared oppression. However, this study intends to interrogate gender relations in terms of the way cultural and development policies are currently regulating the balance of power between men and women in a rapidly mutating African society. Through a reading of select Nigerian films, the paper examines how Nollywood films construct the heterogeneous roles performed by men …

Ecological Imperialism In Yvonne Owuor Dust Ngũgĩ Wa Thiong'o’S Petals Of Blood, Eguvwebere Adanma Anthonia

International Review of Humanities Studies

Modern African Literature grew out of the need for re-identification and reevaluation of the African cultural heritage. Despite that, colonialism and its legacies continue to have a powerful and lasting impact in Africa. Using two literary texts from East Africa, Kenya, reflecting post-colonial and neo-colonial eras, this study examines the validity of the continuation of Ecological Imperialism in Ngũgĩ wa Thiong'o's Petals of Blood (1977) and Owuor Yvonne Adhiambo's Dust (2013). An analytical appraisal of the texts reveals that the post/neocolonial nation-state, far from embodying the new hope of the masses, is a replica of the colonial master's political system …

The Essential Of Semar Power In The Play Of Bathara Kala Tundhung-Surya Ndadari By Ki Manteb Sudarsono, Dewi Dian Lestari, Darmoko Darmoko

International Review of Humanities Studies

This paper discusses the essential of Semar Power in the puppet play entitled Bathara Kala Tundhung-Surya Ndadari. The play Bathara Kala Tundhung-Surya Ndadari was taken into consideration in conducting this research because it is a unique play, namely the Ruwat play and the Mahabharata story play which were united through the experience of the presence of Semar characters in a puppet play by Ki Manteb Sudarsono. The main problem in this research is how the essence of Semar Power is formulated in Batara Kala Tundhung-Surya Ndadari. This study aims to formalize Semar's power as the holder of the superiority of …

Diaspora In Indonesia-China Relationship At The Comprehensive Strategic Partnership Era, R. Tuty Nur Mutia Enoch Muas

International Review of Humanities Studies

Diaspora is a potential non-state actor as a driver of people-to-people connections between the country of origin and the country of residence. People-to-people connections are part of public diplomacy, increasing in importance with information and communication technology. Indonesia-China relations have existed for more than seven decades, experiencing dynamic ups and downs. Since the inauguration of the Strategic Partnership between Indonesia and China in 2005 and then in 2013, it has increased to become a Comprehensive Strategic Partnership, and bilateral and multilateral relations have tended to increase. Bilateral and multilateral relations have managed to grow. However, from the Indonesian side, there …

Ultra-Fast Bioorthogonal Spin-Labeling And Distance Measurements In Mammalian Cells Using Small, Genetically Encoded Tetrazine Amino Acids, Subhashis Jana, Eric G. B. Evans, Hyo Sang Jang, Shuyang Zhang, Hui Zhang, Andrzej Rajca, Sharona E. Gordon, William N. Zagotta, Stefan Stoll, Ryan A. Mehl

Department of Chemistry: Faculty Publications

Studying protein structures and dynamics directly in the cellular environments in which they function is essential to fully understand the molecular mechanisms underlying cellular processes. Site-directed spin-labeling (SDSL)—in combination with double electron–electron resonance (DEER) spectroscopy—has emerged as a powerful technique for determining both the structural states and the conformational equilibria of biomacromolecules. In-cell DEER spectroscopy on proteins in mammalian cells has thus far not been possible due to the notable challenges of spin-labeling in live cells. In-cell SDSL requires exquisite biorthogonality, high labeling reaction rates and low background signal from unreacted residual spin label. While the bioorthogonal reaction must be …

An Integrated Multi-Omics Analysis Of Sleep-Disordered Breathing Traits Implicates P2xr4 Purinergic Signaling, Nuzulul Kurniansyah, Danielle A Wallace, Ying Zhang, Bing Yu, Brian Cade, Heming Wang, Heather M Ochs-Balcom, Alexander P Reiner, Alberto R Ramos, Joshua D Smith, Jianwen Cai, Martha Daviglus, Phyllis C Zee, Robert Kaplan, Charles Kooperberg, Stephen S Rich, Jerome I Rotter, Sina A Gharib, Susan Redline, Tamar Sofer

Faculty, Staff and Student Publications

Sleep Disordered Breathing (SDB) is a common disease associated with increased risk for cardiometabolic, cardiovascular, and cognitive diseases. How SDB affects the molecular environment is still poorly understood. We study the association of three SDB measures with gene expression measured using RNA-seq in multiple blood tissues from the Multi-Ethnic Study of Atherosclerosis. We develop genetic instrumental variables for the associated transcripts as polygenic risk scores (tPRS), then generalize and validate the tPRS in the Women's Health Initiative. We measure the associations of the validated tPRS with SDB and serum metabolites in Hispanic Community Health Study/Study of Latinos. Here we find …

How To Boost Egyptian Pharmaceutical Exports? Challenges And Opportunities, Shereen Mohamed Abdelgawad

Theses and Dissertations

One of the key pillars of the Egyptian economic reform adopted in 2016 was to raise the export rate. Since the pharmaceutical sector is one of Egypt's most established industries, the Egyptian government worked on a national plan to support the exports of medicines. Despite the impact of pharmaceutical exports on economic growth, there was limited research on this topic in Egypt. This study aims to provide a better knowledge of the problems of exporting medications in Egypt by investigating barriers and Covid-19 influence on pharmaceutical export. In-depth semi-structured interviews with representatives from pharmaceutical exporting companies have been conducted. The …

Legality Of Autonomous Weapons: Where To Draw The Line?, Nayra Abdeltawab Ibrahim Abdeltawab

Theses and Dissertations

Inspired by Koskenniemi’s work, From Apology to Utopia, this paper attempts to engage in the discussion on the legality of autonomous weapons by showing the conflicting arguments presented by advocates of each side of the debate. The paper does not aim at finding the answer to whether autonomous weapons can be lawfully deployed or not, but rather its main interest is to highlight the indeterminacy within international law that allows both advocates and opponents of banning autonomous weapons to hold to their arguments and legally defend them on basis of the same legal rules used by their adversaries to refute …

A Captive’S Subjectivity, Rebeca J. Blemur

Theses and Dissertations

The project discusses the effects of Haiti’s colonization as the space transitions from Hispaniola to Saint-Domingue and later to the free state of Haiti. This is done by studying the concept of the right to conquest and the absurdities that exist around the first appearances of international law. The project focuses on the pre-revolutionary period starting around the 1750s, the revolutionary period that began in the 1790s, the French oligarchical class’s attempt for social equality, and the war for ultimate colonial conquest between the French, Spanish, and British. The project will display how legally objectifying a human being manifests subjects …

Visual Literacy Of Molecular Biology Revealed Through A Card-Sorting Task, Dina L. Newman, Hannah Spector, Anna Neuenschwander, Anna J. Miller, Lauren Trumpore, Leslie Kate Wright

Articles

Visual literacy, which is the ability to effectively identify, interpret, evaluate, use, and create images and visual media, is an important aspect of science literacy. As molecular processes are not directly observable, researchers and educators rely on visual representations (e.g., drawings) to communicate ideas in biology. How learners interpret and organize those numerous diagrams is related to their underlying knowledge about biology and their skills in visual literacy. Furthermore, it is not always obvious how and why learners interpret diagrams in the way they do (especially if their interpretations are unexpected), as it is not possible to “see” inside the …

Influence Of Aerobic Exercise On Appetite-Regulating Hormones, Ghrelin-O-Acyltransferase And Perceived Hunger In Normal Weight And Obese Adults, Michael Bruneau, Richard Wood, Susan Sotir, Samuel Headley, Elizabeth O'Neil, Juan Muñiz, May Cheung, Marissa Pontarelli

Department of Medical Oncology Faculty Papers

Background: Obesity is a major public health issue in the United States (U.S.), affecting an estimated 78 million US adults. Aerobic exercise (AE) is recommended by the American College of Sports Medicine to prevent and treat obesity, yet the effects of AE on circulating hunger hormones including acylated ghrelin and its biological catalyst, ghrelin o-acyltransferase (GOAT) are less known. Objectives: We investigated the effects of AE on circulating concentrations of appetite regulating hormones and GOAT in a pilot sample of adults classified with normal weight (NW) and obese (OB) body weight status. Methods: Using a quasi-experimental design, nine adults with …

Small Molecule Egfr Inhibitors As Anti-Cancer Agents: Discovery, Mechanisms Of Action, And Opportunities, Tanzida Zubair, Debasish Bandyopadhyay

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Epidermal growth factor receptors (EGFRs) are a class of receptor tyrosine kinase that are also called ErbB1 and HER1. EGFR tyrosine kinase activity inhibition is considered a promising therapeutic strategy for the treatment of cancer. Many small-molecule inhibitors of EGFR tyrosine kinase (EGFR-TK), from medicinally privileged molecules to commercial drugs, have been overviewed. Particular attention has been paid to the structure of the molecule and its mechanism of action if reported. Subsequent classification of the molecules under discussion has been carried out. Both natural and synthetic and reversible and irreversible EGFR-tyrosine kinase inhibitors have been discussed. Various types of cancers …

Amplifying Local Leadership: A Twitter Analysis Of Indonesian Responses To The Covid-19 Pandemic, Bevaola Kusumasari, Fadhli Zul Fauzi, Anang Dwi Santoso

BISNIS & BIROKRASI: Jurnal Ilmu Administrasi dan Organisasi

Social media has altered emergency communication between local governments and citizens. Studies on social media and natural disasters are expanding. Few studies have explored the crisis of social media use among local government officials. This study investigated how Indonesian leaders use social media. It used data scraping techniques with the Twitter API and the http://tweepy.readthedocs.io/en/v3.5.0/api.html#tweepy-api-twitter-api-wrapper library to collect tweets from each governor's account in Bahasa, Indonesia, between January 1, 2020, and December 31, 2020. The collected data were stored in a MySQL database to facilitate manual analysis and converted to text format. The data were manually labeled using a three-step …

Gene Expression Profiling Of Circulating Tumor Cells Captured By Microcavity Array Is Superior To Enumeration In Demonstrating Therapy Response In Patients With Newly Diagnosed Advanced And Locally Advanced Non-Small Cell Lung Cancer, Evan N Cohen, Gitanjali Jayachandran, Hui Gao, Phillip Peabody, Heather B Mcbride, Franklin D Alvarez, Pablo Lopez Bravo, Wei Qiao, Suyu Liu, Luyang Yao, Steven H Lin, James M Reuben

Faculty, Staff and Student Publications

Background: Circulating tumor cells (CTCs) are a promising non-invasive tool for monitoring therapy response. The only Food and Drug Administration (FDA)-approved test is limited to enumeration of epithelial CTC without further characterization and is not approved for the management of non-small cell lung cancer (NSCLC). Here we use a MicroCavity Array (MCA) system to capture CTC agnostic of epithelial markers for further molecular testing in NSCLC.

Methods: CTCs were enumerated by fluorescent microscopy as longitudinal sampling throughout disease management from 213 NSCLC patients. CTC-enriched samples from a subset of 127 patients were interrogated for gene expression by reverse transcription polymerase …

Association Between Covid-19 And Postoperative Neurological Complications And Antipsychotic Medication Use After Cancer Surgery: A Retrospective Study, Juan P Cata, Jian Hu, Lei Feng, Caroline Chung, Scott E Woodman, Larissa A Meyer

Faculty, Staff and Student Publications

Introduction: Millions of Americans infected with the severe acute respiratory syndrome-associated coronavirus-19 (COVID-19) need oncologic surgery. Patients with acute or resolved COVID-19 illness complain of neuropsychiatric symptoms. How surgery affects postoperative neuropsychiatric outcomes such as delirium is unknown. We hypothesize that patients with a history of COVID-19 could have an exaggerated risk of developing postoperative delirium after undergoing major elective oncologic surgery.

Methods: We conducted a retrospective study to determine the association between COVID-19 status and antipsychotic drugs during postsurgical hospitalization as a surrogate of delirium. Secondary outcomes included 30 days of postoperative complications, length of stay, and mortality. Patients …

Lnc-Uc147 Is Associated With Disease Stage Of Liver, Gastric, And Renal Cancer, Ana Carolina Rodrigues, Erika Pereira Zambalde, Daniel De Lima Bellan, Edvaldo Da Silva Trindade, Enilze Maria De Souza Fonseca Ribeiro, George Calin, Daniela Fiori Gradia, Jaqueline Carvalho De Oliveira

Faculty, Staff and Student Publications

Lnc-uc.147, a long non-coding RNA derived from a transcribed ultraconserved region (T-UCR), was previously evidenced in breast cancer. However, the role of this region in other tumor types was not previously investigated. The present study aimed to investigate lnc-uc.147 in different types of cancer, as well as to suggest lnc-uc.147 functional and regulation aspects. From solid tumor datasets analysis of The Cancer Genome Atlas (TCGA), deregulated lnc-uc.147 expression was associated with the histologic grade of hepatocellular carcinoma, and with the tumor stage of clear cell renal and gastric adenocarcinoma. Considering the epidemiologic relevance of liver cancer, silencing lnc-uc.147 reduced the …