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Spartan Daily, February 7, 2023, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2023

Volume 160, Issue 5

Human Saliency-Driven Patch-Based Matching For Interpretable Post-Mortem Iris Recognition, Aidan Boyd, Daniel Moreira, Andrey Kuehlkamp, Kevin Bowyer, Adam Czajka

Computer Science: Faculty Publications and Other Works

Forensic iris recognition, as opposed to live iris recognition, is an emerging research area that leverages the discriminative power of iris biometrics to aid human examiners in their efforts to identify deceased persons. As a machine learning-based technique in a predominantly human-controlled task, forensic recognition serves as “back-up” to human expertise in the task of post-mortem identification. As such, the machine learning model must be (a) interpretable, and (b) post-mortem-specific, to account for changes in decaying eye tissue. In this work, we propose a method that satisfies both requirements, and that approaches the creation of a post-mortem-specific feature extractor in …

Production Of A Monoclonal Antibody For The Detection Of Forchlorfenuron: Application In An Indirect Enzyme-Linked Immunosorbent Assay And Immunochromatographic Strip, Xingmei Lei, A M Abd El-Aty, Lingyuan Xu, Jing Zhao, Jia Li, Song Gao, Yun Zhao, Yongxin She, Fen Jin, Jing Wang, Lufei Zheng, Maojun Jin, Bruce D Hammock

Faculty, Staff and Student Publications

In this study, a monoclonal antibody (mAb) specific to forchlorfenuron (CPPU) with high sensitivity and specificity was produced and designated (9G9). To detect CPPU in cucumber samples, an indirect enzyme-linked immunosorbent assay (ic-ELISA) and a colloidal gold nanobead immunochromatographic test strip (CGN-ICTS) were established using 9G9. The half-maximal inhibitory concentration (IC50) and the LOD for the developed ic-ELISA were determined to be 0.19 ng/mL and 0.04 ng/mL in the sample dilution buffer, respectively. The results indicate that the sensitivity of the antibodies prepared in this study (9G9 mAb) was higher than those reported in the previous literature. On the other …

Evaluation Of New Potential Inflammatory Markers In Patients With Nonvalvular Atrial Fibrillation, Gabriela Lopes Martins, Rita Carolina Figueiredo Duarte, Érica Leandro Marciano Vieira, Natália Pessoa Rocha, Estêvão Lanna Figueiredo, Francisco Rezende Silveira, José Raymundo Sollero Caiaffa, Rodrigo Pinheiro Lanna, Maria Das Graças Carvalho, András Palotás, Cláudia Natália Ferreira, Helton José Reis

Faculty, Staff and Student Publications

Atrial fibrillation (AF), the most common arrhythmia in clinical practice, is associated with an increase in mortality and morbidity due to its high potential to cause stroke and systemic thromboembolism. Inflammatory mechanisms may play a role in the pathogenesis of AF and its maintenance. We aimed to evaluate a range of inflammatory markers as potentially involved in the pathophysiology of individuals with nonvalvular AF (NVAF). A total of 105 subjects were enrolled and divided into two groups: patients with NVAF (n = 55, mean age 72 ± 8 years) and a control group of individuals in sinus rhythm (n = …

Identification Of Volatile Organic Liquids By Combining An Array Of Fiber-Optic Sensors And Machine Learning, Wassana Naku, Anand K. Nambisan, Muhammad Roman, Chen Zhu, Rex E. Gerald, Jie Huang

Electrical and Computer Engineering Faculty Research & Creative Works

In This Paper, We Report an Array of Fiber-Optic Sensors based on the Fabry-Perot Interference Principle and Machine Learning-Based Analyses for Identifying Volatile Organic Liquids (VOLs). Three Optical Fiber Tip Sensors with Different Surfaces Were Included in the Array of Sensors to Improve the Accuracy for Identifying Liquids: An Intrinsic (Unmodified) Flat Cleaved Endface, a Hydrophobic-Coated Endface, and a Hydrophilic-Coated Endface. the Time-Transient Responses of Evaporating Droplets from the Optical Fiber Tip Sensors Were Monitored and Collected Following the Controlled Immersion Tests of 11 Different Organic Liquids. a Continuous Wavelet Transform Was Used to Convert the Time-Transient Response Signal into …

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Targeted Protein Degradation Via Lysosomes, Rishi R Paudel, Dong Lu, Sandipan Roy Chowdhury, Erika Y Monroy, Jin Wang

Faculty, Staff and Students Publications

In the scope of targeted protein degradation (TPD), proteolysis-targeting chimeras (PROTACs), leveraging the ubiquitin-proteasome system, have been extensively studied. However, they are limited to the degradation of soluble and membrane proteins, excluding the aggregated and extracellular proteins and dysfunctional organelles. As an alternative protein degradation pathway, lysosomes serve as a feasible tool for accessing these untouched proteins and/or organelles by proteosomes. Here, we focus on reviewing the emerging lysosome-mediated TPD, such as AUTAC, ATTEC, AUTOTAC, LYTAC, and MoDE-A. Intracellular targets, such as soluble and aggregated proteins and organelles, can be degraded via the autophagy-lysosome pathway. Extracellular targets, such as membrane …

The Role Of The Neurodevelopmental Disorder Gene Myt1l In Mammalian Brain Development, Jiayang Chen

Arts & Sciences Graduate Student Theses and Dissertations

Recent human genetic studies have associated mutations in a gene called Myelin Transcription Factor 1 Like (MYT1L) with neurodevelopmental disorders (NDDs). Patients with MYT1L loss of function (LoF) mutations (MYT1L Syndrome patients) demonstrate shared symptoms such as microcephaly, attention deficit and hyperactivity disorder (ADHD), and obesity. Despite prior studies showing MYT1L overexpression facilitates neuronal differentiation in vitro, its functions in vivo, especially in the mammalian brain, and how its mutation leads to human disease pathology remains poorly understood. Here, I established the first mouse model of MYT1L Syndrome mimicking a patient specific LoF mutation. I found mice with Myt1l heterozygous …

Modeling And Analysis Of The Intrinsic Cardiac Nervous System In Closed-Loop Cardiovascular Control, Michelle M. Gee, Abraham M. Lenhoff, James S. Schwaber, Babatunde A. Ogunnaike, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The baroreceptor reflex is a multi-input, multi-output physiological control system that regulates short-term blood pressure by modulating nerve activity between the brainstem and the heart. The computational model by Park et al. (2020) is the most recent iteration in our exploration of the system. However, the contributions of”the little brain of the heart”, the intrinsic cardiac nervous system (ICN), to local control of the heart and to the integration of sensory information is unknown and has been overlooked in previous models. We have incorporated a high-fidelity representation of the ICN into a model of the baroreceptor reflex based on anatomical, …

Effects Of Neighborhood Disadvantage And Peer Deviance On Conduct Problems: Interactions With Age Of Onset, Courtney Marie Goetz

LSU Master's Theses

Youth with conduct problems (CP) generally fall into two developmental classifications, child-onset and adolescent-onset, which exhibit different causal processes and life course trajectories. Research suggests that child-onset CP is more likely to be related to individual predispositions, while adolescent-onset CP is more associated with social factors, such as peer delinquency. Living in impoverished and disorganized neighborhoods increases the risk for associating with deviant peers. Thus, the current study tested the hypothesis that neighborhood factors would be more strongly associated with adolescent-onset CP than child-onset CP, which would be explained by a greater association with deviant peers. Linear and negative binomial …

Metabolic Individuality: Limitations, Challenges, And Potential For Clinical Utility, Sarah H Elsea, Jennifer E Posey

Faculty, Staff and Students Publications

In Nature Medicine, Surendran and colleagues recently reported the analysis of human plasma metabolomic data for 913 metabolites in ∼20,000 individuals, identifying 2,599 metabolite-genetic variant associations and >400 metabolite signatures comprised of jointly regulated metabolites. This extensive atlas of variant-metabolite relationships reveals novel genomic mechanisms driving metabolic phenotypes.

Post-Transcriptional Regulation In Cranial Neural Crest Cells Expands Developmental Potential, Rachel A Keuls, Young Sun Oh, Ivanshi Patel, Ronald J Parchem

Faculty, Staff and Students Publications

Developmental potential is progressively restricted after germ layer specification during gastrulation. However, cranial neural crest cells challenge this paradigm, as they develop from anterior ectoderm, yet give rise to both ectodermal derivatives of the peripheral nervous system and ectomesenchymal bone and cartilage. How cranial neural crest cells differentiate into multiple lineages is poorly understood. Here, we demonstrate that cranial neural crest cells possess a transient state of increased chromatin accessibility. We profile the spatiotemporal emergence of premigratory neural crest and find evidence of lineage bias toward either a neuronal or ectomesenchymal fate, with each expressing distinct factors from earlier stages …

Gender, Sexual Orientation, Ethnicity And Socioeconomic Factors Influence How Wildland Firefighters Communicate Their Work Experiences, Miranda Ragland, Jennifer Harrell, Molly Ripper, Seth Pearson, Rachel Granberg, Robin M. Verble

Biological Sciences Faculty Research & Creative Works

As Climates Change, Natural Resource Professionals Are Often Working on the Frontlines of Intensifying Environmental Disasters, Acting in Both Scientific and Emergency Response Roles. One Subset of This Group, Wildland Firefighters Often Engage in Multifaceted Careers that Incorporate Elements of Resource Planning, Conservation Management, Community Disaster Relief, and Operational Management. Despite These STEM Roles and Nearly Half (48%) of Them Having Earned at Least a bachelor's degree, usually in a STEM Field, Wildland Firefighters Are Almost Exclusively Lumped with Emergency Responders in the Scientific Literature. We Surveyed 708 Wildland Firefighters with 9 Open Response Questions as Part of a Larger …

Evaluation Of Apparent Diffusion Coefficient Repeatability And Reproducibility For Preclinical Mris Using Standardized Procedures And A Diffusion-Weighted Imaging Phantom, Dariya Malyarenko, Ghoncheh Amouzandeh, Stephen Pickup, Rong Zhou, Henry Charles Manning, Seth T Gammon, Kooresh I Shoghi, James D Quirk, Renuka Sriram, Peder Larson, Michael T Lewis, Robia G Pautler, Paul E Kinahan, Mark Muzi, Thomas L Chenevert

2020-Current year OA Pubs

Relevant to co-clinical trials, the goal of this work was to assess repeatability, reproducibility, and bias of the apparent diffusion coefficient (ADC) for preclinical MRIs using standardized procedures for comparison to performance of clinical MRIs. A temperature-controlled phantom provided an absolute reference standard to measure spatial uniformity of these performance metrics. Seven institutions participated in the study, wherein diffusion-weighted imaging (DWI) data were acquired over multiple days on 10 preclinical scanners, from 3 vendors, at 6 field strengths. Centralized versus site-based analysis was compared to illustrate incremental variance due to processing workflow. At magnet isocenter, short-term (intra-exam) and long-term (multiday) …

Structures Of Human Gastrin-Releasing Peptide Receptors Bound To Antagonist And Agonist For Cancer And Itch Therapy, Shuman Peng, Yuting Zhan, Dongqi Zhang, Lu Ren, Anqi Chen, Zhou-Feng Chen, Haitao Zhang

2020-Current year OA Pubs

Gastrin releasing peptide receptor (GRPR), a member of the bombesin (BBN) G protein-coupled receptors, is aberrantly overexpressed in several malignant tumors, including those of the breast, prostate, pancreas, lung, and central nervous system. Additionally, it also mediates non-histaminergic itch and pathological itch conditions in mice. Thus, GRPR could be an attractive target for cancer and itch therapy. Here, we report the inactive state crystal structure of human GRPR in complex with the non-peptide antagonist PD176252, as well as two active state cryo-electron microscopy (cryo-EM) structures of GRPR bound to the endogenous peptide agonist gastrin-releasing peptide and the synthetic BBN analog …

A Comprehensive Framework For The Use Of Sugarcane Bagasse Ash As Cement And Sand Replacement In Concrete Materials, Sujata Subedi

LSU Doctoral Dissertations

Sugarcane bagasse ash (BA), an agricultural byproduct, has been suggested as a sustainable material to partially replace cement and sand in traditional concrete. However, the feasibility of using BA in novel concrete materials, such as engineered cementitious composites (ECC) and fiber-reinforced geopolymer composites (FRGC), has not been investigated. Therefore, the objectives of this study are to: (a) characterize the properties of Louisiana BA produced from different methodologies; (b) quantify the influence of BA as supplementary cementitious material (SCM) on concrete properties; (c) assess the feasibility of developing normal- and high-strength ECCs using BA as SCM and fine aggregate, and (d) …

Full Issue

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

No abstract provided.

Scholars Speak At Fair Conference

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

Scholars from BYU spoke at the recent FAIR (Foundation for Apologetic Information and Research) LDS Apologetics Conference held in August at Utah Valley State College, in Orem, Utah. FAIR, which is not affiliated with BYU or the Institute, is an organization dedicated to defending LDS beliefs and practices with sound scholarship. The theme of the conference was "Turning Stumbling Blocks to Stepping Stones: Responding to Challenging Issues in Mormonism."

First Volumes In New Meti Series Published

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

The Institute's Middle Eastern Texts Initiative has published the first two volumes in its Graeco-Arabic Sciences and Philosophy series: Moses Maimonides' On Asthma and Averroes' Middle Commentary on Aristotle's De anima.

2023 Sdsu Data Science Symposium Speaker Information, Department Of Mathematics & Statistics

SDSU Data Science Symposium

This document contains speaker information and bios for the 2023 SDSU Data Science Symposium.

Nuclear Weapons In Russia’S War Against Ukraine, Stephen Blank

Naval War College Review

Western concern about Russian nuclear weapons’ potential deployment continues to suffuse policy responses to the Ukraine war, inhibiting relief efforts. Russia’s rhetoric and past exercises contribute to the pervasive Western belief that Russia might use nuclear weapons, including in a conflict that begins as a purely conventional war, to force its enemies to accept its terms.

Sensing And Automation Technologies For Ornamental Nursery Crop Production: Current Status And Future Prospects, Md Sultan Mahmud, Azlan Zahid, Anup Kumar Das

Agricultural and Environmental Sciences Faculty Research

The ornamental crop industry is an important contributor to the economy in the United States. The industry has been facing challenges due to continuously increasing labor and agricultural input costs. Sensing and automation technologies have been introduced to reduce labor requirements and to ensure efficient management operations. This article reviews current sensing and automation technologies used for ornamental nursery crop production and highlights prospective technologies that can be applied for future applications. Applications of sensors, computer vision, artificial intelligence (AI), machine learning (ML), Internet-of-Things (IoT), and robotic technologies are reviewed. Some advanced technologies, including 3D cameras, enhanced deep learning models, …

Faculty Senate Monthly Packet February 2023, Portland State University Faculty Senate

Faculty Senate Monthly Packets

The February 6, 2023 Monthly packet includes the February agenda and appendices and the Faculty Senate minutes and attachments from the meeting held January 9, 2023.

Ecophysiological Implications Of Low Lignin In Eastern Leatherwood (Dirca Palustris L.), Anna Cole, Kayla Marie Rigdon, D. Gordon Brown, Katharine Lora Cary

Biology Faculty Publications

Dirca palustris L. (eastern leatherwood) is an understory shrub found throughout much of eastern North America. Dirca palustris wood has a low concentration of lignin, which is a molecule that grants structural rigidity to cell walls. The branches of D. palustris are thus remarkably flexible, but their low lignin content could cause greater vulnerability to water stress. We examined the conductivity, vessel anatomy, and field water potential of D. palustris and conducted ecological surveys. The data showed that D. palustris was not experiencing substantial drought-induced dysfunction in the field, even during an exceptionally hot and dry summer. Its water potentials …

2023 February 06 - Faculty Senate Agenda And Minutes, Faculty Senate, East Tennessee State University

Faculty Senate Agendas and Minutes

No abstract provided.

The Scarabaeoid Beetles Of Maryland (Coleoptera), Dana L. Price, Brett C. Ratcliffe

Zea E-Books Collection

This research recognizes 267 species of scarabaeoid beetles occurring in Maryland. We provide a brief overview of the geology, climate, and vegetation of the state. Keys to the families within Scarabaeoidea occurring in Maryland are provided. We also offer an introduction for each family, keys to all taxa, species descriptions, distributions, and distribution maps for all species, months that adults are observed, notes on their natural history, illustrations, and a glossary of terms. Maryland’s species are found in eight families: Lucanidae (7), Passalidae (1), Geotrupidae (17), Trogidae (18), Ochodaeidae (1), Hybosoridae (2), Glaphyridae (1), and Scarabaeidae (220).

Published as Bulletin …

Redbird Buzz Episode 17: Dean Of The College Of Engineering Dr. Thomas Keyser, Feburary 6, 2023, John Twork, Tom Keyser

Redbird Buzz (2022-2025)

Dr. Thomas Keyser, founding dean of Illinois State University's College of Engineering, shares his vision for the new college, set to launch with its first class of students in the fall of 2025. Keyser discusses his plans for educating "career ready" graduates and engaging with local industry leaders to provide College of Engineering students with invaluable real-world experience.

Keyser will begin his tenure at Illinois State on April 1, focused on bringing the University's newest academic college into being with three critical goals: workforce development, student success, and diversifying the engineering field. To learn more about the College of Engineering, …

Intestinal Toxicity To Ctla-4 Blockade Driven By Il-6 And Myeloid Infiltration, Yifan Zhou, Yusra B Medik, Bhakti Patel, Daniel B Zamler, Sijie Chen, Thomas Chapman, Sarah Schneider, Elizabeth M Park, Rachel L Babcock, Taylor T Chrisikos, Laura M Kahn, Allison M Dyevoich, Josue E Pineda, Matthew C Wong, Aditya K Mishra, Samuel H Cass, Alexandria P Cogdill, Daniel H Johnson, Sarah B Johnson, Khalida Wani, Debora A Ledesma, Courtney W Hudgens, Jingjing Wang, Md Abdul Wadud Khan, Christine B Peterson, Aron Y Joon, Weiyi Peng, Haiyan S Li, Reetakshi Arora, Ximing Tang, Maria Gabriela Raso, Xuegong Zhang, Wai Chin Foo, Michael T Tetzlaff, Gretchen E Diehl, Karen Clise-Dwyer, Elizabeth M Whitley, Matthew M Gubin, James P Allison, Patrick Hwu, Nadim J Ajami, Adi Diab, Jennifer A Wargo, Stephanie S Watowich

Faculty, Staff and Student Publications

Immune checkpoint blockade (ICB) has revolutionized cancer treatment, yet quality of life and continuation of therapy can be constrained by immune-related adverse events (irAEs). Limited understanding of irAE mechanisms hampers development of approaches to mitigate their damage. To address this, we examined whether mice gained sensitivity to anti-CTLA-4 (αCTLA-4)–mediated toxicity upon disruption of gut homeostatic immunity. We found αCTLA-4 drove increased inflammation and colonic tissue damage in mice with genetic predisposition to intestinal inflammation, acute gastrointestinal infection, transplantation with a dysbiotic fecal microbiome, or dextran sodium sulfate administration. We identified an immune signature of αCTLA-4–mediated irAEs, including colonic neutrophil accumulation …

Assessment Of Response To Neoadjuvant Systemic Treatment In Triple-Negative Breast Cancer Using Functional Tumor Volumes From Longitudinal Dynamic Contrast-Enhanced Mri, Bikash Panthi, Beatriz E Adrada, Rosalind P Candelaria, Mary S Guirguis, Clinton Yam, Medine Boge, Huiqin Chen, Kelly K Hunt, Lei Huo, Ken-Pin Hwang, Anil Korkut, Deanna L Lane, Huong C Le-Petross, Jessica W T Leung, Jennifer K Litton, Rania M Mohamed, Benjamin C Musall, Sanaz Pashapoor, Miral M Patel, Frances Perez, Jong Bum Son, Alastair Thompson, Vicente Valero, Peng Wei, Jason White, Zhan Xu, Lawrence Pinsky, Debu Tripathy, Wei Yang, Jingfei Ma, Gaiane M Rauch

Faculty, Staff and Student Publications

Early assessment of neoadjuvant systemic therapy (NAST) response for triple-negative breast cancer (TNBC) is critical for patient care in order to avoid the unnecessary toxicity of an ineffective treatment. We assessed functional tumor volumes (FTVs) from dynamic contrast-enhanced (DCE) MRI after 2 cycles (C2) and 4 cycles (C4) of NAST as predictors of response in TNBC. A group of 100 patients with stage I-III TNBC who underwent DCE MRI at baseline, C2, and C4 were included in this study. Tumors were segmented on DCE images of 1 min and 2.5 min post-injection. FTVs were measured using the optimized percentage enhancement …

Taking Initiative: Utilizing Louisiana Law To Protect Honey Bees And Fill Regulatory Gaps In Federal Pesticide Laws, Bailey Anderson

LSU Journal of Energy Law and Resources

No abstract provided.