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Classical American Pragmatism As Antiscientism, Parysa Clare Mostajir

Researchers, Instructors, & Staff Scholarship

Scientism has recently experienced a resurgence of interest in philosophy. One version of scientism often defended is ontological scientism—the view that any kind or property not mentioned in the theories of science has only a subordinate, secondary kind of reality. It is worth noting that a dominant tradition in the history of philosophy of science—classical American pragmatism—undertook decades of critical engagement with contemporaneous scientistic beliefs, many of which resemble those being debated at the present time. This antiscientistic philosophy has multiple points of relevance for contemporary debates and defenses of ontological scientism.

Sugars And Cuticular Waxes Impact Sugarcane Aphid (Melanaphis Sacchari) Colonization On Different Developmental Stages Of Sorghum, Juan David Betancurt Cardona, Sajjan Grover, Michael J. Bowman, Lucas Busta, Pritha Kundu, Kyle G. Koch, Gautam Sarath, Scott E. Sattler, Joe Louis

Department of Entomology: Faculty Publications

Sugarcane aphid (SCA; Melanaphis sacchari) is a devastating pest of sorghum (Sorghum bicolor) that colonizes sorghum plants at different growth stages. Leaf surface characteristics and sugars often influence aphid settling and feeding on host plants. However, how changes in cuticular waxes and sugar levels affect SCA establishment and feeding at different development stages of sorghum have not been explored. In this study, two- and six-weekold BTx623 plants, a reference line of sorghum, was used to evaluate plant-aphid interactions. Monitoring aphid feeding behavior using Electrical Penetration Graph (EPG) technique revealed that aphids spent more time in the sieve …

Attention-Based Explainability Approaches In Healthcare Natural Language Processing, Haadia Amjad, Mohammad Ashraf, Syed Sherazi, Saad Khan, Muhammad Moazam Fraz, Tahir Hameed, Syed Ahmad Chan Bukhari

Management Faculty Publications

Artificial intelligence (AI) systems are becoming common for decision support. However, the prevalence of the black-box approach in developing AI systems has been raised as a significant concern. It becomes very crucial to understand how an AI system makes decisions, especially in healthcare, since it directly impacts human life. Clinical decision support systems (CDSS) frequently use Natural Language Processing (NLP) techniques to extract information from textual data including Electronic Health Records (EHRs). In contrast to the prevalent black box approaches, emerging ’Explainability’ research has improved our comprehension of the decision-making processes in CDSS using EHR data. Many researches use ’attention’ …

Gloria - A Globally Representative Hyperspectral In Situ Dataset For Optical Sensing Of Water Quality, Moritz K. Lehmann, Daniela Gurlin, Nima Pahlevan, Krista Alikas, Janet Anstee, Sundarabalan V. Balasubramanian, Cláudio C.F. Barbosa, Caren Binding, Astrid Bracher, Mariano Bresciani, Ashley Burtner, Zhigang Cao, Arnold G. Dekker, Courtney Di Vittorio, Nathan Drayson, Reagan M. Errera, Virginia Fernandez, Dariusz Ficek, Cédric G. Fichot, Peter Gege, Claudia Giardino, Anatoly A. Gitelson, Steven R. Greb, Hayden Henderson, Hiroto Higa, Abolfazl Irani Rahaghi, Cédric Jamet, Dalin Jiang, Thomas Jordan, Kersti Kangro, Jeremy A. Kravitz

Michigan Tech Publications, Part 1

The development of algorithms for remote sensing of water quality (RSWQ) requires a large amount of in situ data to account for the bio-geo-optical diversity of inland and coastal waters. The GLObal Reflectance community dataset for Imaging and optical sensing of Aquatic environments (GLORIA) includes 7,572 curated hyperspectral remote sensing reflectance measurements at 1 nm intervals within the 350 to 900 nm wavelength range. In addition, at least one co-located water quality measurement of chlorophyll a, total suspended solids, absorption by dissolved substances, and Secchi depth, is provided. The data were contributed by researchers affiliated with 59 institutions worldwide and …

Serum Cotinine As A Predictor Of Lipid-Related Indices In Turkish Immigrants With Type 2 Diabetes: A Clinic-Based Cross-Sectional Study, Shiryn D. Sukhram, Gustavo G. Zarini, Lemia H. Shaban, Joan A. Vaccaro, Avinash R. Sukhram, Fatma G. Huffman

Publications and Research

Background: Turkish immigrants form the largest ethnic minority group in the

Netherlands and show a higher prevalence of (i) cardiovascular disease (CVD),

(ii) cigarette smoking, and (iii) type 2 diabetes (T2D) as compared to the native

Dutch. This study examines the association of CVD risk factors: serum cotinine, as

an indicator of cigarette smoke, and lipid-related indices among first-generation

(foreign-born) Turkish immigrants with T2D living in deprived neighbourhoods in the

Netherlands.

Methods: A total of 110 participants, physician-diagnosed with T2D, aged 30 years

and older, were recruited by convenience sampling from the Schilderswijk

neighbourhood of The Hague in a clinic-based …

The Cowl - V. 87 N. 12 - February 16, 2023

The Cowl

The Cowl - student newspaper of Providence College. Vol. 87 No. 12 - February 16, 2023. 16 pages.

Profibrotic Behavior Of Fibroblasts Derived From Patients That Develop Posttraumatic Shoulder Stiffness, Benjamin A. Hendy, Jolanta Fertala, Thema Nicholson, Joseph A. Abboud, Surena Namdari, Andrzej Fertala

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND AND AIMS: Arthrofibrosis is a severe scarring condition characterized by joint stiffness and pain. Fundamental to developing arthrofibrotic scars is the accelerated production of procollagen I, a precursor of collagen I molecules that form fibrotic deposits in affected joints. The procollagen I production mechanism comprises numerous elements, including enzymes, protein chaperones, and growth factors. This study aimed to elucidate the differences in the production of vital elements of this mechanism in surgical patients who developed significant posttraumatic arthrofibrosis and those who did not.

METHODS: We studied a group of patients who underwent shoulder arthroscopic repair of the rotator cuff. …

Antibody Development To Identify Components Of Iis And Mtor Signaling Pathways In Lepidopteran Species, A Set Of Non-Model Insects, Alissa R. Armstrong, Carol Boggs

Faculty Publications

Nutritional stress impacts many insect species that have differing reproductive strategies and life histories, yet it is unclear how nutrient-sensing signaling pathways mediate tissue-specific responses to changes in dietary input. In Drosophila melanogaster , insulin/insulin-like growth factor (IIS) and mTOR-mediated signaling within adipocytes regulates oogenesis. To facilitate comparative study of nutrient-sensing pathway activity in the fat body, we developed antibodies to assess IIS (anti-FOXO) and mTOR signaling (anti-TOR) across three nymphalid species (Lepidoptera). By optimizing whole-mount fat body immunostaining, we find FOXO nuclear enrichment in adult adipocytes, like that observed in Drosophila . Additionally, we show a previously uncharacterized TOR …

Akt/Mtor Signaling Modulates Resistance To Endocrine Therapy And Cdk4/6 Inhibition In Metastatic Breast Cancers, Maysa M. Abu-Khalaf, K. Alex Hodge, Christos Hatzis, Elisa Baldelli, Emna El Gazzah, Frances Valdes, William M. Sikov, Monica M. Mita, Neelima Denduluri, Rita Murphy, Daniel Zelterman, Lance Liotta

Kimmel Cancer Center Faculty Papers

Endocrine therapy (ET) in combination with CDK4/6 inhibition is routinely used as first-line treatment for HR+/HER2− metastatic breast cancer (MBC) patients. However, 30–40% of patients quickly develop disease progression. In this open-label multicenter clinical trial, we utilized a hypothesis-driven protein/phosphoprotein-based approach to identify predictive markers of response to ET plus CDK4/6 inhibition in pre-treatment tissue biopsies. Pathway-centered signaling profiles were generated from microdissected tumor epithelia and surrounding stroma/immune cells using the reverse phase protein microarray. Phosphorylation levels of the CDK4/6 downstream substrates Rb (S780) and FoxM1 (T600) were higher in patients with progressive disease (PD) compared to responders (p = …

Gene Bigler Oral History Interview, Gene Bigler, Lorenzo Spaccarelli

Raymond College

No abstract provided.

Point/Counterpoint: Transgender Sport Participation Policy, Nafees Alam, Matt Moore

Social Work Faculty Publications

Professor Alam and Professor Moore submitted a Point/Counterpoint commentary article regarding the National Collegiate Athletic Association (NCAA) Board of Governors Transgender Sport Participation Policy

Genome-Wide Identification, Characterization, And Expression Analysis Of Spiral1 Family Genes In Legume Species, Qianxia Yu, Junjie Liu, Jiayu Jiang, Fudong Liu, Zhen Zhang, Xiaoye Yu, Mengru Li, Intikhab Alam, Liangfa Ge

Faculty, Staff and Student Publications

The SPIRAL1 (SPR1) gene family encodes microtubule-associated proteins that are essential for the anisotropic growth of plant cells and abiotic stress resistance. Currently, little is known about the characteristics and roles of the gene family outside of Arabidopsis thaliana. This study intended to investigate the SPR1 gene family in legumes. In contrast to that of A. thaliana, the gene family has undergone shrinking in the model legume species Medicago truncatula and Glycine max. While the orthologues of SPR1 were lost, very few SPR1-Like (SP1L) genes were identified given the genome size of the two …

Food Safety Practices - Slides From 02-14-2023 Webinar, Wendy Johnecheck

UNH Cooperative Extension

No abstract provided.

Functional Connectivity Signatures Of Nmdar Dysfunction In Schizophrenia—Integrating Findings From Imaging Genetics And Pharmaco-Fmri, Arnim J Gaebler, Nilüfer Fakour, Felix Stöhr, Jana Zweerings, Arezoo Taebi, Mariia Suslova, Juergen Dukart, Joerg F Hipp, Bhim M Adhikari, Peter Kochunov, Suresh D Muthukumaraswamy, Anna Forsyth, Thomas Eggermann, Florian Kraft, Ingo Kurth, Michael Paulzen, Gerhard Gründer, Frank Schneider, Klaus Mathiak

Faculty, Staff and Student Publications

Both, pharmacological and genome-wide association studies suggest N-methyl-D-aspartate receptor (NMDAR) dysfunction and excitatory/inhibitory (E/I)-imbalance as a major pathophysiological mechanism of schizophrenia. The identification of shared fMRI brain signatures of genetically and pharmacologically induced NMDAR dysfunction may help to define biomarkers for patient stratification. NMDAR-related genetic and pharmacological effects on functional connectivity were investigated by integrating three different datasets: (A) resting state fMRI data from 146 patients with schizophrenia genotyped for the disease-associated genetic variant rs7191183 of GRIN2A (encoding the NMDAR 2 A subunit) as well as 142 healthy controls. (B) Pharmacological effects of the NMDAR antagonist ketamine and the GABA-A …

Structural Basis Of Impaired Disaggregase Function In The Oxidation-Sensitive Skd3 Mutant Causing 3-Methylglutaconic Aciduria, Jose J Gorbea Colón, Leon Palao, Shin-Fu Chen, Hee Jong Kim, Laura Snyder, Yi-Wei Chang, Kuang-Lei Tsai, Kenji Murakami

Faculty, Staff and Student Publications

Most eukaryotic promoter regions are divergently transcribed. As the RNA polymerase II pre-initiation complex (PIC) is intrinsically asymmetric and responsible for transcription in a single direction, it is unknown how divergent transcription arises. Here, the Saccharomyces cerevisiae Mediator complexed with a PIC (Med-PIC) was assembled on a divergent promoter and analyzed by cryoelectron microscopy. The structure reveals two distinct Med-PICs forming a dimer through the Mediator tail module, induced by a homodimeric activator protein localized near the dimerization interface. The tail dimer is associated with ∼80-bp upstream DNA, such that two flanking core promoter regions are positioned and oriented in …

Synthesis Of Enantiomers Of Chiral Ester Derivatives Containing An Amide Group And Their Chiral Recognition By ¹H Nmr Spectroscopy, Yan Lin Li, Hong Mei Zhao, Yu Qing Ren, Meng Qiu, Hai Tong Zhang, Guang Peng Gao, Li Zheng, Pericles Stavropoulos, Lin Ai

Chemistry Faculty Research & Creative Works

Enantiomers of Chiral Ester Derivatives Containing an Amide Group and Possessing One or Two Stereogenic Centers Were Prepared from L- and D-Α-Amino Acids, and Glycine with (S)- and (R)-Mandelic Acid for Probing their Chiral Recognition as a New Class of Chiral Guests by 1H NMR Spectroscopy, Since Chiral Ester Derivatives Have Been Rarely Used as Chiral Substrates for Chiral Recognition by 1H NMR Technology. the Results Indicated that These Chiral Ester Derivatives Have Been Successfully Differentiated in the Presence of Tetraaza Macrocyclic Chiral Solvating Agents (TAMCSAs) 1 A–1 C. in Order to Better Understand their Chiral Discriminating Behavior, Job Plots, …

Emergent Dynamics Of Adult Stem Cell Lineages From Single Nucleus And Single Cell Rna-Seq Of Drosophila Testes, Amelie A Raz, Gabriela S Vida, Sarah R Stern, Sharvani Mahadevaraju, Jaclyn M Fingerhut, Jennifer M Viveiros, Soumitra Pal, Jasmine R Grey, Mara R Grace, Cameron W Berry, Hongjie Li, Jasper Janssens, Wouter Saelens, Zhantao Shao, Chun Hu, Yukiko M Yamashita, Teresa Przytycka, Brian Oliver, Julie A Brill, Henry Krause, Erika L Matunis, Helen White-Cooper, Stephen Dinardo, Margaret T Fuller

Faculty, Staff and Students Publications

Proper differentiation of sperm from germline stem cells, essential for production of the next generation, requires dramatic changes in gene expression that drive remodeling of almost all cellular components, from chromatin to organelles to cell shape itself. Here, we provide a single nucleus and single cell RNA-seq resource covering all of spermatogenesis in Drosophila starting from in-depth analysis of adult testis single nucleus RNA-seq (snRNA-seq) data from the Fly Cell Atlas (FCA) study. With over 44,000 nuclei and 6000 cells analyzed, the data provide identification of rare cell types, mapping of intermediate steps in differentiation, and the potential to identify …

February 16, 2023, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

A Human Stem Cell-Derived Neuronal Model Of Morphine Exposure Reflects Brain Dysregulation In Opioid Use Disorder: Transcriptomic And Epigenetic Characterization Of Postmortem-Derived Ipsc Neurons, Emily F Mendez, Sandra L Grimm, Laura Stertz, Damian Gorski, Sai V Movva, Katherine Najera, Karla Moriel, Thomas D Meyer, Gabriel R Fries, Cristian Coarfa, Consuelo Walss-Bass

Faculty, Staff and Student Publications

INTRODUCTION: Human-derived induced pluripotent stem cell (iPSC) models of brain promise to advance our understanding of neurotoxic consequences of drug use. However, how well these models recapitulate the actual genomic landscape and cell function, as well as the drug-induced alterations, remains to be established. New

METHODS: We engineered a novel induced pluripotent stem cell-derived model of neural progenitor cells and neurons from cultured postmortem human skin fibroblasts, and directly compared these to isogenic brain tissue from the donor source. We assessed the maturity of the cell models across differentiation from stem cells to neurons using RNA cell type and maturity …

Effects Of Feeding Legume Silage With Differing Tannin Levels On Lactating Dairy Cattle, U. C. Hymes Fecht, G. A. Broderick, R. E. Muck

IGC Proceedings (1977-2023)

Condensed tannins (CT) bind to plant proteins in the rumen, reducing protein degradation to ammonia and increasing milk production and milk protein (e.g. Waghorn, 1987). Previous research showed that the reduced soluble non-protein nitrogen (NPN) content of red clover (Trifolium pratense) silage (RCS) was related to its greater N efficiency relative to lucerne (Medicago sativa) silage (LS) (Broderick et al., 2001). Commercial cultivars of birdsfoot trefoil (Lotus corniculatus; BFT) contain modest levels of CT which reduce NPN formation in silage (Albrecht & Muck, 1991). The objective was to compare silages made from BFT …

An Evaluation Of The Inclusion Of Alternative Forages With Grass Silage-Based Diets On Carcass Composition And Meat Quality Of Beef Cattle Offered Two Contrasting Grass Silages, T. W. J. Keady, F. O. Lively, D. J. Kilpatrick, B. W. Moss

IGC Proceedings (1977-2023)

Recent studies have shown that the inclusion of some alternative forages with grass silage-based diets can increase animal performance of beef cattle. The aim of the present study was to evaluate the effects of including either maize or whole crop wheat (WCW) silages with grass silage-based diets on meat quality of beef cattle offered two levels of concentrate.

Blood Meal As A Source Of Histidine For Cattle Fed Grass Silage And Barley, R. Berthiaume, C. Lafrenière

IGC Proceedings (1977-2023)

Previous research has shown that cattle fed grass silage are responsive to protected amino acids (Veira et al., 1991). Methionine and lysine were suggested as the most limiting amino acids for grass silage diets. Recently, Korhonen et al. (2000) have shown that histidine is the first limiting amino acids for dairy cows fed grass silage and barley-based concentrates. However, histidine is not available in a rumen protected form and needs to be provided through dietary ingredients. Blood meal is rich in histidine. This trial was designed to determine the effect of increasing histidine supply through blood meal on …

Nutritive Value For Finishing Beef Steers Of Wheat Grain Conserved By Different Techniques, P. Stacey, P. O'Kiely, A. P. Moloney, F. P. O'Mara

IGC Proceedings (1977-2023)

Wheat grain harvested at dry matter (DM) concentrations above 860 g/kg is slow to deteriorate during long-term storage. However, high moisture grain (HMG) ranging from below 600 to 750 g DM/kg is conserved on some farms in the form of anaerobic storage of acid-treated, rolled wheat (AR) and urea-treated whole-wheat (UN) (Stacey et al., 2003). This experiment quantified the nutritive value for beef cattle of standard wheat grain (propionic acid-treated and rolled:PR) compared to AR and UN at different levels of intake.

Effect Of Additive Treatment On Meat Quality, V. Vrotniakiene, J. Jatkauskas

IGC Proceedings (1977-2023)

Major components of meat quality are physico-chemical properties (including visual appearance and tenderness) and dietetic properties (i.e. fat content and fatty acid composition) (Razminowicz et al., 2004). Physico-chemical and technological properties of meat are influenced by feeding system, feeds quality and various feeds additives (Brzoska et al., 1999). The aim of the present study was compare the influence of untreated, inoculated and chemically-treated legume-grass silage on carcass composition and physico-chemical properties of meat when fed to fattening bulls.

Replacement Of Maize/Soybean Meal Concentrate By High Moisture Maize Grain Plus Wholeseed Soybean Silage For Cattle, C. C. Jobim, A. F. Branco, V. F. Gai, U. Cecato

IGC Proceedings (1977-2023)

Ensiling high moisture maize grain with wholeseed soybean can increase quality of silage, mainly in relation to protein and energy (Jobim et al., 2002) working as concentrate. This fact contributes to reduced use of concentrate and costs for milk and beef production, and costs related to grain storage on the farms. The objective of this study was to evaluate the nutritive value of high moisture maize grain plus wholeseed soybean silage through partial and total digestibility in cattle.

The Effects Of Alfalfa Silage Harvesting Systems On Dry Matter Intake Of Friesland Dairy Ewes In Late Pregnancy, H. F. Elizalde

IGC Proceedings (1977-2023)

With the recent introduction of alfalfa in Chilean Patagonia (Aisén), its utilisation as silage has to be reviewed relative to animal performance. The effect of silage chop length on the voluntary intake has been evaluated in different species, with sheep being more sensitive to chop length than cattle (Dulphy et al., 1984). The objective of this experiment was to evaluate the effects of different alfalfa silage chop lengths on dry matter (DM) intake and eating behaviour of Friesland dairy ewes in late pregnancy.

Effect Of Feeding Red Clover, Lucerne And Kale Silage On The Voluntary Intake And Liveweight Gain Of Growing Lambs, R. Fychan, C. L. Marley, M. D. Fraser, R. Jones

IGC Proceedings (1977-2023)

Despite a need for alternative forages to provide home-grown sources of protein (Wilkins & Jones, 2000), there have been few studies comparing the effects of such forages on lamb production when fed as silage. In this experiment the effects of offering ensiled red clover (Trifolium pratense), lucerne (Medicago sativa) and kale (Brassica oleracea) on voluntary intake and liveweight gain in growing lambs were compared.

An Evaluation Of Grain Processing And Storage Method, And Feed Level On The Performance And Meat Quality Of Beef Cattle Offered Two Contrasting Grass Silages, T. W. J. Keady, F. O. Lively, D. J. Kilpatrick

IGC Proceedings (1977-2023)

Traditionally cereals have been dried or treated with propionic acid and processed prior to feeding to finishing beef cattle. Recently new techniques have been developed for storing and feeding grain to beef cattle. The objective of the current study was to evaluate the effects of grain storage and processing method, and grain feed level on performance and meat quality of beef cattle offered two contrasting feed value grass silages.

Feeding Mixed Grass-Clover Silages With Elevated Sugar Contents To Dairy Cows, J. Bertilsson

IGC Proceedings (1977-2023)

Grasses with high sugar content (WSC) have been claimed to increase feed intake and milk production and at the same time give more efficient N utilisation and thus reduce pollution (e.g. Miller et al., 2001). In an ongoing EU-supported project (“Sweetgrass”), we have grown the new varieties of perennial ryegrasses and fed them to dairy cows. Results from the first year’s experiment when pure ryegrass silages made from standard or high-sugar varieties were fed, showed small differences in feed intake, milk production and N partitioning. In order to test the principle, it was therefore decided to increase the difference …

Modelling Contamination Of Raw Milk With Butyric Acid Bacteria Spores, M. M. M. Vissers, F. Driehuis, P. De Jong, M. C. Te Giffel, J. M. G. Lankveld

IGC Proceedings (1977-2023)

Raw milk contains low concentrations of bacterial endospores, originating from the farm environment (e.g. soil, feeds, faeces). Spores of Clostridium tyrobutyricum, also called butyric acid bacterium (BAB), are of great interest to the dairy industry. They survive milk pasteurisation and cause off-flavours and texture defects in various cheese types. The contamination pathway of BAB spores is well known. Their primary origin is soil. In silage the number of spores will increase if conditions permit BAB growth. The spores are excreted in the cows faeces and are transferred to milk by contaminated teat surfaces. Many factors are involved in the …