Digital Commons Network^™

Perceptions Of Undergraduate Nursing Students On Racism And Racial Disparities In Maternal Health, Monika Costa

Dissertations

The United States has persistent racial inequities in maternal health, with African American women experiencing the highest maternal mortality and morbidity (Centers for Disease Control and Prevention, 2020). Structural inequities, racism, implicit and explicit biases, and discrimination contribute to disparities in maternal health outcomes in the United States (Alshusen et al., 2016; Davis, 2019; Institute of Medicine, 2003, Liese et al., 2019, National Academies of Sciences, Engineering, and Medicine, 2020). In recent years, racial discrimination and bias have been important topics of discussion. However, very little research has been done about nursing curricular preparedness to address implicit bias and racism …

Ms 027 Guide To Felix Haas, Phd Papers (1937-1986), Felix Hass

Manuscript Finding Aids

The collection is arranged in nine series, reflecting various dimensions of Dr. Haas' career. Within each series, files are primarily arranged alphabetically. See more at MS 027.

Find Gene Expression Data Quickly, Grace Salmons, Aaron Joyce Fabelico, James Wengler, Stephen R. Piccolo

Library/Life Sciences Undergraduate Poster Competition 2023

Public repositories are:

• vital for validating studies

• incredible for addressing novel hypothesis.

However, it can be difficult to find data related to discrete topics due to:

• large quantity of data

• heterogeneity in how researchers describe their data and study designs.

Manual annotation of data cannot keep pace with the rapid pace of science. We turned to Natural Language Processing (NLP) for a solution!

February 21, 2023 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Saved Babies, Dead Doctors: Settler Colonial Anxiety And Strategic Rhetorics Of/In The Anti-Abortion Cultural Narrative, Cassidy Ellis

Communication ETDs

In this dissertation I identify and analyze the rhetoric that creates the anti-abortion cultural narrative and locate its toxic secrets by exposing the logics and ideologies the secrets obscure and sustain, and finally, ascertaining the strategic rhetorics that enable the narrative’s power and centrality. There are two primary arguments proposed in this dissertation. First, I argue that settler colonialism is the primary toxic secret nestled just beneath the surface of the anti-abortion cultural narrative. It is the secret that animates and sustains the narrative in service of maintaining settler colonial social order via control and maintenance of the population. Second, …

Minutes, Curriculum Committee Meeting, Tuesday, February 21, 2023, Curriculum Committee

Curriculum Committee Minutes

No abstract provided.

Team Moms And Tiger Moms: Formal Sports Participation And Closeness To Mothers: Supplementary Materials, Tom R. Leppard, Mikaela J. Dufur

Faculty Publications

Recent research highlights that relationships with parents are among those strengthened when youth play sports. This recent work, however, largely focuses on fathers, arguing that because of the persistent emphasis on masculinity in sporting spaces, youth sports might be especially effective at facilitating stronger relationships between fathers and children. This chapter asks how the mother-child dyad is influenced by youth formal participation in sports during their adolescence, including whether these patters differ for daughters and sons. The intense time investments the entire family unit incurs to support youth sport participation might be borne primarily by mothers; this in turn might …

Lacrimal Gland Epithelial Cells Shape Immune Responses Through The Modulation Of Inflammasomes And Lipid Metabolism, Vanessa Delcroix, Olivier Mauduit, Menglu Yang, Amrita Srivastava, Takeshi Umazume, Cintia S De Paiva, Valery I Shestopalov, Darlene A Dartt, Helen P Makarenkova

Faculty, Staff and Students Publications

Lacrimal gland inflammation triggers dry eye disease through impaired tear secretion by the epithelium. As aberrant inflammasome activation occurs in autoimmune disorders including Sjögren's syndrome, we analyzed the inflammasome pathway during acute and chronic inflammation and investigated its potential regulators. Bacterial infection was mimicked by the intraglandular injection of lipopolysaccharide (LPS) and nigericin, known to activate the NLRP3 inflammasome. Acute injury of the lacrimal gland was induced by interleukin (IL)-1α injection. Chronic inflammation was studied using two Sjögren's syndrome models: diseased

British Colonialism And Imperialism, Atreyee Majumder, Sandeep Banerjee

Popular Media

Oxford Bibliographies provides faculty and students alike with a seamless pathway to the most accurate and reliable resources for a variety of academic topics. Written and reviewed by academic experts, every article in their database is an authoritative guide to the current scholarship, containing original commentary and annotations. This bibliography focuses on the relationship between British colonialism in India and the development of modern Hinduism.

Exploring The Impacts Of The Covid-19 Pandemic On The Number Of Reported Missing Persons In Canada During 2020, Alexandria Connolly, Mauranne Ste-Marie, Kevin O'Shea

International Journal of Missing Persons

The COVID-19 pandemic has resulted in notable social and economic impacts in many countries, including Canada. This study examines the impacts of the COVID-19 pandemic on the number of reported missing persons, adults and children, in Canada during 2020. Results indicate that there was a decrease in the number of reported missing persons cases during 2020 as compared to 2019 by 20.20%. All provinces and territories experienced a decrease, with the exception of New Brunswick. The pandemic had notable impacts specifically on the number of reported missing children, missing teenagers, and missing male individuals in general. This study provides a …

Identification Of Small-Molecule Inhibitors Of The Salmonella Frab Deglycase Using A Live-Cell Assay, Anice Sabag-Daigle, Erin F Boulanger, Pankajavalli Thirugnanasambantham, Jamison D Law, Alex J Bogard, Edward J Behrman, Venkat Gopalan, Brian M M Ahmer

Faculty, Staff and Student Publications

Nontyphoidal salmonellosis is one of the most significant foodborne diseases in the United States and globally. There are no vaccines available for human use to prevent this disease, and only broad-spectrum antibiotics are available to treat complicated cases of the disease. However, antibiotic resistance is on the rise and new therapeutics are needed. We previously identified the Salmonella fraB gene, that mutation of causes attenuation of fitness in the murine gastrointestinal tract. The FraB gene product is encoded in an operon responsible for the uptake and utilization of fructose-asparagine (F-Asn), an Amadori product found in several human foods. Mutations in …

A Cryptic Oxidoreductase Safeguards Oxidative Protein Folding In Corynebacterium Diphtheriae, Melissa E Reardon-Robinson, Minh Tan Nguyen, Belkys C Sanchez, Jerzy Osipiuk, Christian Rückert, Chungyu Chang, Bo Chen, Rahul Nagvekar, Andrzej Joachimiak, Andreas Tauch, Asis Das, Hung Ton-That

Faculty, Staff and Student Publications

In many gram-positive Actinobacteria, including Actinomyces oris and Corynebacterium matruchotii, the conserved thiol-disulfide oxidoreductase MdbA that catalyzes oxidative folding of exported proteins is essential for bacterial viability by an unidentified mechanism. Intriguingly, in Corynebacterium diphtheriae, the deletion of mdbA blocks cell growth only at 37 °C but not at 30 °C, suggesting the presence of alternative oxidoreductase enzyme(s). By isolating spontaneous thermotolerant revertants of the mdbA mutant at 37 °C, we obtained genetic suppressors, all mapped to a single T-to-G mutation within the promoter region of tsdA, causing its elevated expression. Strikingly, increased expression of tsdA—via …

Predicting Patient-Specific Tumor Dynamics: How Many Measurements Are Necessary?, Isha Harshe, Heiko Enderling, Renee Brady-Nicholls

Faculty, Staff and Student Publications

Acquiring sufficient data is imperative to accurately predict tumor growth dynamics and effectively treat patients. The aim of this study was to investigate the number of volume measurements necessary to predict breast tumor growth dynamics using the logistic growth model. The model was calibrated to tumor volume data from 18 untreated breast cancer patients using a varying number of measurements interpolated at clinically relevant timepoints with different levels of noise (0-20%). Error-to-model parameters and the data were compared to determine the sufficient number of measurements needed to accurately determine growth dynamics. We found that without noise, three tumor volume measurements …

Emerging Treatments For Myelodysplastic Syndromes: Biological Rationales And Clinical Translation, Juan Jose Rodriguez-Sevilla, Vera Adema, Guillermo Garcia-Manero, Simona Colla

Faculty, Staff and Student Publications

Myelodysplastic syndromes (MDSs) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by myeloid dysplasia, peripheral blood cytopenias, and increased risk of progression to acute myeloid leukemia (AML). The standard of care for patients with MDS is hypomethylating agent (HMA)-based therapy; however, nearly 50% of patients have no response to the treatment. Patients with MDS in whom HMA therapy has failed have a dismal prognosis and no approved second-line therapy options, so enrollment in clinical trials of experimental agents represents these patients' only chance for improved outcomes. A better understanding of the molecular and biological mechanisms underpinning MDS …

Rational Targets Of Therapy In Extranodal Nk/T-Cell Lymphoma, Ajay Major, Pierluigi Porcu, Bradley M Haverkos

Department of Medical Oncology Faculty Papers

Extranodal NK/T-cell lymphoma (ENKTL) is an aggressive extranodal non-Hodgkin lymphoma (NHL) with poor outcomes, particularly in advanced-stage and relapsed/refractory disease. Emerging research on molecular drivers of ENKTL lymphomagenesis by next-generation and whole genome sequencing has revealed diverse genomic mutations in multiple signaling pathways, with the identification of multiple putative targets for novel therapeutic agents. In this review, we summarize the biological underpinnings of newly-understood therapeutic targets in ENKTL with a focus on translational implications, including epigenetic and histone regulatory aberrations, activation of cell proliferation signaling pathways, suppression of apoptosis and tumor suppressor genes, changes in the tumor microenvironment, and EBV-mediated …

Marginalized Populations And Trauma-Informed Practices At The Secondary Level: Understanding The Connections Between Trauma Exposure And Academic Outcomes Through An Intersectional Framework, Kirsten Hany

Theses and Dissertations

This research seeks to understand the relationship between marginalized identities and trauma in adolescents in relation to classroom outcomes, both behavioral and academic, through an intersectional framework. A synthesized review of literature as well as a quantitative study using the HSLS:09 data was conducted to discern how marginalized populations experience trauma in the school environment, and how that trauma impacts academic outcomes. The conclusions drawn through the review of literature and research suggest that marginalized students experience trauma at higher rates as well as disruption of academic outcomes. These conclusions are disseminated in chapter III which is a practitioner piece …

Pan-Cancer Molecular Subtypes Of Metastasis Reveal Distinct And Evolving Transcriptional Programs, Yiqun Zhang, Fengju Chen, Chad J Creighton

Faculty, Staff and Students Publications

Molecular mechanisms underlying cancer metastasis span diverse tissues of origin. Here, we synthesize and collate the transcriptomes of patient-derived xenografts and patient tumor metastases, and these data collectively represent 38 studies and over 3,000 patients and 4,000 tumors. We identify four expression-based subtypes of metastasis transcending tumor lineage. The first subtype has extensive copy alterations, higher expression of MYC transcriptional targets and DNA repair genes, and bromodomain inhibitor response association. The second subtype has higher expression of genes involving metabolism and prostaglandin synthesis and regulation. The third subtype has evidence of neuronal differentiation, higher expression of DNA and histone methylation …

Fixitfelix: Improving Genomic Analysis By Fixing Reference Errors, Sairam Behera, Jonathon Lefaive, Peter Orchard, Medhat Mahmoud, Luis F Paulin, Jesse Farek, Daniela C Soto, Stephen C J Parker, Albert V Smith, Megan Y Dennis, Justin M Zook, Fritz J Sedlazeck

Faculty, Staff and Students Publications

The current version of the human reference genome, GRCh38, contains a number of errors including 1.2 Mbp of falsely duplicated and 8.04 Mbp of collapsed regions. These errors impact the variant calling of 33 protein-coding genes, including 12 with medical relevance. Here, we present FixItFelix, an efficient remapping approach, together with a modified version of the GRCh38 reference genome that improves the subsequent analysis across these genes within minutes for an existing alignment file while maintaining the same coordinates. We showcase these improvements over multi-ethnic control samples, demonstrating improvements for population variant calling as well as eQTL studies.

Slo3 In The Fast Lane: The Latest Male Contraceptive Target With A Promising Small-Molecule Inhibitor, Zhi Tan, Thomas X Garcia

Faculty, Staff and Students Publications

No abstract provided.

Editorial: Community Series In Tools, Techniques, And Strategies For Teaching In A Real-World Context With Microbiology, Volume Ii, Davida S. Smyth, Nicole A. Broderick, Carlos C. Goller

All Faculty Scholarship (Archived)

This Research Topic is the second volume in the Community Series Tools, Techniques, and Strategies for Teaching in a Real-World Context with Microbiology. Making microbiology relevant to our students increases student engagement with science, which could not be more important as we emerge from the COVID-19 pandemic. We have learned much during this period as we adapted and modified our learning environments and strategies, all while demonstrating the many ways microbes impact our world beyond disease. Placing microbes at center stage leads to engaging and exciting curricula and assignments. Microbes also are wonderful tools as they are easy to manipulate …

Investigating How Urban Landscapes Alter Freshwater Environments, Matthew Schuler

Sustainability Seminar Series

Investigating how urban landscapes alter freshwater environments

Comparison Of Dna Extraction Methods For Soft Tissue Samples, Steve Guzman, Nathaniel E. Hill, Mujtaba Shah, Jonathon Reynolds, Cole Farnsworth, Molly Henley, Alfred Amendolara, Laura Minor, John Dougherty Jr., John A. Kriak, Kyle B. Bills, David W. Sant

Annual Research Symposium

No abstract provided.

Vitamin C Contributes To Epigenetic Regulation Of Genes Related To Diabetic Retinopathy In Retinal Endothelial Cells, Elizabeth L. Turner, Jonathon Reynolds, Walker Kay, Marianne Becnel, Matthew Conway, Alexander Kim, John A. Kriak, Kyle B. Bills, David W. Sant

Annual Research Symposium

No abstract provided.

Determination Of Feasibility And Plausibility Of Using Various Biological Samples For Remote Genetic Testing, Cole Farnsworth, Molly Henley, Walker Kay, Varos Victer Manukyan, Jonathon Reynolds, John A. Kriak, Kyle B. Bills, David W. Sant

Annual Research Symposium

No abstract provided.

Development Of An Affordable, Manual Method Of Dna Extraction From Bones And Teeth ​, Varos Victer Manukyan, Lara Laughrey, Ryan V. Powers, Amar Paul, Davis Johnston, Dashon Eure, Todeh Toomians, John A. Kriak, Kyle B. Bills, David W. Sant

Annual Research Symposium

No abstract provided.

Applications Of Platelet-Rich Fibrin In Oral And Maxillofacial Surgery, Sheva Schwartz, Claudia Freitas

Annual Research Symposium

No abstract provided.

Detection And Relative Quantitation Of Changes In Gene Expression Of Heat Shock Proteins 27 (Hsp27), Hsp 70, Hsp 90 And Hsp 47 In Doxorubicin-Exposed Human Cells By Rt-Qpcr, Steve Lee, Christopher So Dr.

Annual Research Symposium

Gene expression

Cell cultures

Heat shock proteins

The Effects Of Vitamin B1 Analog, Benfotiamine, On The Prevention Of Non-Small Cell Lung Cancer, Emely Fernandez, Hannah Christensen, Kota A. Ramana

Annual Research Symposium

No abstract provided.

The Immunomodulating Effects Of Delta-9 Tetrahydrocannabinol (Thc) And Cannabidiol (Cbd) In The Context Of Infection, Rose D. Goodman, Kate Rouse, Victor Jimenez

Annual Research Symposium

No abstract provided.

A Ligand-Based Approach To Identifying Commercially Available Inhibitors Of Human Galactokinase (Galk), Tyler Rose

Annual Research Symposium

The purpose of this project was to find inhibitors of the human galactokinase (GALK) enzyme. GALK is responsible for catalyzing the conversion of galactose to galactose 1-phosphate, the first step in galactose metabolism. Galactose 1-phosphate builds up in the cells of patients with type 1 galactosemia due a genetic disorder. It has been proposed that inhibiting galactose 1-phosphate production by GALK may prevent many of the major complications of type 1 galactosemia. In this study, a ligand-based approach was used to identify commercially available inhibitors of GALK, starting from galactose-bearing natural products. Candidate inhibitors were screened for their ability to …