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Intouch Week Of February 27, 2023, New York Medical College

InTouch

• NYMC and WMCHealth Network Host Sixth Annual HeLa Conference
• Community Read Book Discussion Spotlights the Inequalities in Dental Care
• Harvey: An Educational Tool for NYMC for More Than 20 Years
• NYMC Celebrates National Heart Month
• NYMC Helps 99 Local Patients with Blood Drive Organized by Donate Life Club and New York Blood Center

Analysis Of Acquired Resistance Mechanisms To Osimertinib In Patients With Egfr-Mutated Advanced Non-Small Cell Lung Cancer From The Aura3 Trial, Juliann Chmielecki, Tony Mok, Yi-Long Wu, Ji-Youn Han, Myung-Ju Ahn, Suresh S Ramalingam, Thomas John, Isamu Okamoto, James Chih-Hsin Yang, Frances A Shepherd, Krishna C Bulusu, Gianluca Laus, Barbara Collins, J Carl Barrett, Ryan J Hartmaier, Vassiliki Papadimitrakopoulou

Faculty, Staff and Student Publications

Osimertinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), potently and selectively inhibits EGFR-TKI-sensitizing and EGFR T790M resistance mutations. This analysis evaluates acquired resistance mechanisms to second-line osimertinib (n = 78) in patients with EGFR T790M advanced non-small cell lung cancer (NSCLC) from AURA3 (NCT02151981), a randomized phase 3 study comparing osimertinib with chemotherapy. Plasma samples collected at baseline and disease progression/treatment discontinuation are analyzed using next-generation sequencing. Half (50%) of patients have undetectable plasma EGFR T790M at disease progression and/or treatment discontinuation. Fifteen patients (19%) have >1 resistance-related genomic alteration; MET amplification (14/78, 18%) and EGFR C797X mutation …

Neural Responses To Biological Motion Distinguish Autistic And Schizotypal Traits, Matthew Hudson, Severi Santavirta, Vesa Putkinen, Kerttu Seppälä, Lihua Sun, Tomi Karjalainen, Henry K. Karlsson, Jussi Hirvonen, Lauri Nummenmaa

School of Psychology

Difficulties in social interactions characterize both autism and schizophrenia, and are correlated in the neurotypical population. It is unknown whether this represents a shared etiology or superficial phenotypic overlap. Both conditions exhibit atypical neural activity in response to the perception of social stimuli and decreased neural synchronization between individuals. This study investigated if neural activity and neural synchronization associated with biological motion perception are differentially associated with autistic and schizotypal traits in the neurotypical population. Participants viewed naturalistic social interactions whilst hemodynamic brain activity was measured with fMRI, which was modelled against a continuous measure of the extent of biological …

Uncovering Novel Regulators Of Memory Using C Elegans Genetic And Genomic Analysis, Katie L Brandel-Ankrapp, Rachel N Arey

Faculty, Staff and Students Publications

How organisms learn and encode memory is an outstanding question in neuroscience research. Specifically, how memories are acquired and consolidated at the level of molecular and gene pathways remains unclear. In addition, memory is disrupted in a wide variety of neurological disorders; therefore, discovering molecular regulators of memory may reveal therapeutic targets for these disorders. C. elegans are an excellent model to uncover molecular and genetic regulators of memory. Indeed, the nematode's invariant neuronal lineage, fully mapped genome, and conserved associative behaviors have allowed the development of a breadth of genetic and genomic tools to examine learning and memory. In …

The Tfiis N-Terminal Domain (Tnd): A Transcription Assembly Module At The Interface Of Order And Disorder, Katerina Cermakova, Vaclav Veverka, H Courtney Hodges

Faculty, Staff and Students Publications

Interaction scaffolds that selectively recognize disordered protein strongly shape protein interactomes. An important scaffold of this type that contributes to transcription is the TFIIS N-terminal domain (TND). The TND is a five-helical bundle that has no known enzymatic activity, but instead selectively reads intrinsically disordered sequences of other proteins. Here, we review the structural and functional properties of TNDs and their cognate disordered ligands known as TND-interacting motifs (TIMs). TNDs or TIMs are found in prominent members of the transcription machinery, including TFIIS, super elongation complex, SWI/SNF, Mediator, IWS1, SPT6, PP1-PNUTS phosphatase, elongin, H3K36me3 readers, the transcription factor MYC, and …

Shock-Induced Endotheliopathy (Shine): A Mechanistic Justification For Viscoelastography-Guided Resuscitation Of Traumatic And Non-Traumatic Shock., Connor M. Bunch, Eric Chang, Ernest E. Moore, Hunter B. Moore, Hau C. Kwaan, Joseph B. Miller, Mahmoud D. Al-Fadhl, Anthony V. Thomas, Nuha Zackariya, Shivani S. Patel, Sufyan Zackariya, Saadeddine Haidar, Bhavesh Patel, Michael T. Mccurdy, Scott G. Thomas, Donald Zimmer, Daniel Fulkerson, Paul Y. Kim, Matthew R. Walsh, Daniel Hake, Archana Kedar, Michael Aboukhaled, Mark M. Walsh

Emergency Medicine Articles

Irrespective of the reason for hypoperfusion, hypocoagulable and/or hyperfibrinolytic hemostatic aberrancies afflict up to one-quarter of critically ill patients in shock. Intensivists and traumatologists have embraced the concept of SHock-INduced Endotheliopathy (SHINE) as a foundational derangement in progressive shock wherein sympatho-adrenal activation may cause systemic endothelial injury. The pro-thrombotic endothelium lends to micro-thrombosis, enacting a cycle of worsening perfusion and increasing catecholamines, endothelial injury, de-endothelialization, and multiple organ failure. The hypocoagulable/hyperfibrinolytic hemostatic phenotype is thought to be driven by endothelial release of anti-thrombogenic mediators to the bloodstream and perivascular sympathetic nerve release of tissue plasminogen activator directly into the microvasculature. …

Important Ice Processes Are Missed By The Community Earth System Model In Southern Ocean Mixed-Phase Clouds: Bridging Socrates Observations To Model Developments, Xi Zhao, Xiaohong Liu, Susannah Burrows, Paul J. Demott, Minghui Diao, Greg M. Mcfarquhar, Sachin Patade, Vaughan Phillips, Greg C. Roberts, Kevin J. Sanchez, Yang Shi, Meng Zhang

Faculty Research, Scholarly, and Creative Activity

Global climate models (GCMs) are challenged by difficulties in simulating cloud phase and cloud radiative effect over the Southern Ocean (SO). Some of the new-generation GCMs predict too much liquid and too little ice in mixed-phase clouds. This misrepresentation of cloud phase in GCMs results in weaker negative cloud feedback over the SO and a higher climate sensitivity. Based on a model comparison with observational data obtained during the Southern Ocean Cloud Radiation and Aerosol Transport Experimental Study, this study addresses a key uncertainty in the Community Earth System Model version 2 (CESM2) related to cloud phase, namely ice formation …

Molecular Research In Pancreatic Cancer: Small Molecule Inhibitors, Their Mechanistic Pathways And Beyond, Shaila A. Shetu, Nneoma James, Gildardo Rivera-Sanchez, Debasish Bandyopadhyay

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Pancreatic enzymes assist metabolic digestion, and hormones like insulin and glucagon play a critical role in maintaining our blood sugar levels. A malignant pancreas is incapable of doing its regular functions, which results in a health catastrophe. To date, there is no effective biomarker to detect early-stage pancreatic cancer, which makes pancreatic cancer the cancer with the highest mortality rate of all cancer types. Primarily, mutations of the KRAS, CDKN2A, TP53, and SMAD4 genes are responsible for pancreatic cancer, of which mutations of the KRAS gene are present in more than 80% of pancreatic cancer cases. Accordingly, there is a …

Back Country: Queer Rural Temporalities, Pansies In The Bluegrass, Cooper Lane Gibson

Theses and Dissertations

My practice utilizes an intermedia and anti-disciplinary approach to conjure a reflexive vision of my experience as a gay and gender non-conforming person in rural Kentucky. Concepts that are important to my practice are storytelling, embodiment, and assemblage. Coming up gay in rural Kentucky I often felt like an assemblage. Not quite one thing entirely, but many parts swirling together in a fluidity that isn’t easily categorizable. Part farm boy, part faggot, part miss piggy. I am also interested in assemblage as a way of making. Found objects and images are tools I employ as a way of inviting the …

Trpv1-Mediated Sonogenetic Neuromodulation Of Motor Cortex In Freely Moving Mice, Kevin Xu, Yaoheng Yang, Zhongtao Hu, Yimei Yue, Yan Gong, Jianmin Cui, Joseph P Culver, Michael R Bruchas, Hong Chen

2020-Current year OA Pubs

No abstract provided.

Evaluating Metabolic And Genomic Data For Predicting Grain Traits Under High Night Temperature Stress In Rice, Ye Bi, Rafael Massahiro Yassue, Puneet Paul, Balpreet Kaur Dhatt, Jaspreet Sandhu, Phuc Thi Do, Harkamal Walia, Toshihiro Obata, Gota Morota

Department of Agronomy and Horticulture: Faculty Publications

The asymmetric increase in average nighttime temperatures relative to increase in average daytime temperatures due to climate change is decreasing grain yield and quality in rice. Therefore, a better genome-level understanding of the impact of higher night temperature stress on the weight of individual grains is essential for future development of more resilient rice. We investigated the utility of metabolites obtained from grains to classify high night temperature (HNT) conditions of genotypes, and metabolites and single-nucleotide polymorphisms (SNPs) to predict grain length, width, and perimeter phenotypes using a rice diversity panel. We found that the metabolic profiles of rice genotypes …

Why The Delay In Recognizing Terrestrial Obligate Cave Species In The Tropics?, Francis G. Howarth

International Journal of Speleology

“Nothing could possibly live there!” They believed. Indeed, until recently, few specialized cave- adapted animals were known from volcanic, tropical, or oceanic island caves, and plausible theories had been put forward to explain their absence. But assume nothing in science! One must illuminate, explore, and survey habitats before declaring them barren. Our understanding of cave biology changed dramatically about 50 years ago following the serendipitous discovery of cave-adapted terrestrial arthropods in Brazil and on the young oceanic islands of the Galápagos and Hawai‘i. These discoveries and subsequent studies on the evolutionary ecology of cave animals have revealed a remarkable hidden …

Carissa Carandas L. Fruit Mediated In Vitro Synthesis Of Silver Nanoparticles And Their Antioxidant And Antibacterial Activities, Azharuddin B. Daphedar, Tejashwini Basavaprabhu, Viashnavi Nilagar, Annapoorna Waddar

Al-Bahir

Currently, we synthesized silver nanoparticles (AgNPs) from the aqueous fruit extract of Carissa carandas L. and evaluated their antioxidant and antibacterial properties. The UV-visible spectra showed a characteristic absorption peak at 412 nm. The Fourier transform infrared (FTIR) spectroscopy exhibits intense peaks at 3430.23cm-1 and 1625.67cm-1 which indicates the involvement of flavonoids and other functional groups in the biosynthesis, capping, and stabilization of AgNPs. From XRD analysis, the average size of AgNPs was estimated to be 45nm. The biogenic AgNPs were spherical in shape and average size range between 10 to 95nm confirmed by HR-TEM analysis. The fabricated AgNPs by …

Terada Torahiko, A Physicist And A Haikai Poet, Akira Komiya

CLCWeb: Comparative Literature and Culture

Terada Torahiko is known as a scientific essayist in Japan, but hardly anyone knows he was a haikai poet as well as a physicist. According to him, haikai poetry and physics are two different ways of conceiving Nature, both valid and perhaps complementary to each other. Seeing his research in physics looking for regularities in apparently irregular phenomena in everyday life, we may say his haiku haikai spirit is manifest there and that he was pioneering a new science such as the one developed later by Ilya Prigogine. His association of haiku haikai poetry and Freudian interpretations of dreams leads …

Ultrasound-Assisted Air-Jet Spinning Of Silk Fibroin-Soy Protein Nanofiber Composite Biomaterials., Futian Yang, Fang Wang, Janine Mazahreh, Xiao Hu

College of Science & Mathematics Departmental Research

Ultrasound utilizes a non-radiation technology that can meet modern standards to gain access to cheap, reliable and sustainable modern energy. Ultrasound technology can be implemented in the field of biomaterials for its exceptional potential in controlling the shape of nanomaterials. This study presents the first example of the production of soy and silk fibroin protein composite nanofibers in various ratios via combining ultrasonic technology with air-spray spinning. Characterization of ultrasonic spun nanofibers was performed by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric (TG) analysis, water contact angle, water retention, enzymatic …

Ambient Electromagnetic Radiation As A Predictor Of Honey Bee (Apis Mellifera) Traffic In Linear And Non-Linear Regression: Numerical Stability, Physical Time And Energy Efficiency, Vladimir Kulyukin, Daniel Coster, Anastasiia Tkachenko, Daniel Hornberger, Aleksey V. Kulyukin

Computer Science Faculty and Staff Publications

Since bee traffic is a contributing factor to hive health and electromagnetic radiation has a growing presence in the urban milieu, we investigate ambient electromagnetic radiation as a predictor of bee traffic in the hive’s vicinity in an urban environment. To that end, we built two multi-sensor stations and deployed them for four and a half months at a private apiary in Logan, Utah, U.S.A. to record ambient weather and electromagnetic radiation. We placed two non-invasive video loggers on two hives at the apiary to extract omnidirectional bee motion counts from videos. The time-aligned datasets were used to evaluate 200 …

The Emergence Of Specialized Roles Within Groups, Robert L. Goldstone, Edgar J. Andrade-Lotero, Robert D. Hawkins, Michael E. Roberts

Psychology and Neuroscience Faculty Publications

Humans routinely form groups to achieve goals that no individual can accomplish alone. Group coordination often brings to mind synchrony and alignment, where all individuals do the same thing (e.g., driving on the right side of the road, marching in lockstep, or playing musical instruments on a regular beat). Yet, effective coordination also typically involves differentiation, where specialized roles emerge for different members (e.g., prep stations in a kitchen or positions on an athletic team). Role specialization poses a challenge for computational models of group coordination, which have largely focused on achieving synchrony. Here, we present the CARMI …

Florawear: Wearable Living Interface, Hye Yeon Nam, Janiece Campbell, Andrew M. Webb, Brendan Harmon

Faculty Publications

While nature can benefit people both mentally and physically, contemporary society has become increasingly disconnected from nature. To rebuild a stronger connection with nature in our everyday life, we introduce FloraWear, a do-it-yourself, wearable living interface, that enables people to easily and closely connect with plants. This pictorial introduces how knowledge is built and shared with others using hybrid craft and fabrication, illustrates the material experiments and design development for FloraWear, and discusses how it affects wearers. Then we summarize how FloraWear can help catalyze a shift in people's perspectives towards nature. By developing emotional ties to their wearable plants, …

Dedicated To The Life And Work Of Richard J. Bernstein Part Iii: Critique, Dewey Studies

Dewey Studies

Dedicated to the Life and Work of Richard J. Bernstein, edited by Megan Craig and Marcia Morgan.

Part III: Critique

The Association Between Time Spent On Screens And Reading With Myopia, Premyopia And Ocular Biometric And Anthropometric Measures In 6- To 7-Year-Old Schoolchildren In Ireland, Síofra Harrington, Veronica O'Dwyer

Articles

Purpose More time spent on near tasks has consistently been associated with the promotion of myopia. The World Health Organization advises limiting daily screentime to less than 2 h for children aged five and over. This study explored the relationship between time spent on screens and reading/writing with refractive status, ocular biometric and anthropometric factors in 6-to 7-year- olds in Ireland.

Methods Participants were 723 schoolchildren (377 boys [51.8%]), mean age 7.08 (0.45) years. The examination included cycloplegic autorefraction (1% cyclopentolate hydrochloride), ocular biometry (Zeiss IOLMaster), height (cm) and weight (kg). Screentime and reading/writing time were reported by parents/legal guardians …

Kras-Mutant Lung Cancer: Targeting Molecular And Immunologic Pathways, Therapeutic Advantages And Restrictions, Nastaran Karimi, Seyed Javad Moghaddam

Faculty, Staff and Student Publications

RAS mutations are among the most common oncogenic mutations in human cancers. Among RAS mutations, KRAS has the highest frequency and is present in almost 30% of non-small-cell lung cancer (NSCLC) patients. Lung cancer is the number one cause of mortality among cancers as a consequence of outrageous aggressiveness and late diagnosis. High mortality rates have been the reason behind numerous investigations and clinical trials to discover proper therapeutic agents targeting KRAS. These approaches include the following: direct KRAS targeting; synthetic lethality partner inhibitors; targeting of KRAS membrane association and associated metabolic rewiring; autophagy inhibitors; downstream inhibitors; and immunotherapies and …

The Level Of Pedagogical Content Knowledge Of In-Service English Language Teachers In A Foreign Language Context, Dima Hijazi, Amal Al-Natour

Association of Arab Universities Journal for Arts مجلة اتحاد الجامعات العربية للآداب

The aim of this study is to find out the level of pedagogical content knowledge of inservice English language teachers in a foreign language context. The data were collected from 9 in-service English language teachers’ responses on five open-ended grammar, pronunciation and writing problems. The results show that Jordanian English language teachers don’t know enough about what they teach. Furthermore, they show that the integration between what teachers know about what they teach and about the process of teaching and how to teach (PCK) isn’t adequate enough (with a medium level).

Integrating Theatre And Biology: How Embodied Performance Can Enhance Empathy Among College Science Students, Annika C. Speer, Begona Echeverria

The Transdisciplinary STEAM+ Journal

In these field notes, we examine the integration of the arts into a 20-person honors biology seminar at UC Riverside “Beyond Science: Being Humane Amid Human Rights Crises.” We held a four-hour workshop to examine the ways in which performance and theatrical storytelling can enhance science learning. The workshop provided a unique avenue for exploring how human activities result in downward consequences including refugee displacement, one of the course objectives. In addition to the workshop, we conducted surveys and a focus group with the students to better understand their experience incorporating the arts into their science class. A key concept …

Making Meaningful Connections With Steam For Elementary Aged Students In China, Francis Stonier

The Transdisciplinary STEAM+ Journal

This program included a summer STEAM experience for over 130 Chinese elementary aged children. During the week they constructed and tested an egg drop package, explored the local natural history museum, learned about animal footprints and the habitats they live in, dug up dinosaur fossils, and launched rockets. For many, this was their one of their first formal experiences with STEAM activities. The experiences provided a positive introduction or continued support for STEAM at the primary level.

Exhibiting Steam: Curating Community Conversations Through Library Collections, Stefanie Hilles, Ginny Boehme, Rachel Makarowski

The Transdisciplinary STEAM+ Journal

This article discusses the successful collaboration of an art librarian, a science librarian, and a special collections librarian in their efforts to engage the community in STEAM (Science, Technology, Engineering, Arts, and Math) conversations through the curation of a STEAM-based exhibition of artist books. The exhibition was an opportunity to showcase STEAM’s interdisciplinarity through library collections that, until this point, had remained unexplored. The goal was to demonstrate how scientific principles have inspired both contemporary artists and those throughout history, dispelling the myth that artists are not influenced by science. The Libraries’ Special Collections proved an excellent resource to investigate …

Cultivating Ingenuity In Art Through Steam Picture Books, Julia L. Hovanec

The Transdisciplinary STEAM+ Journal

In what creative ways can educators cultivate ingenuity? This article features ten STEAM picture books and their possibilities in the art room and beyond. It equips educators to take on STEAM armed with engaging and inspiring picture books that foster creativity, inventiveness, and more while inspiring students to create, experiment, problem-solve, and construct. There is a focus on one substantive, integrated Art and Science lesson built on the provocative book Summer Birds: The Butterflies of Maria Merian written by Margarita Engle and illustrated by Julie Paschkis. Readers will leave with one complete STEAM challenge-based lesson plan informed by this book …

Steam And Environmental Justice In An Interdisciplinary Context, Paula Farca, Alina Handorean, Jürgen Brune

The Transdisciplinary STEAM+ Journal

This course proposes an interdisciplinary perspective, envisions unique synergies between environmental justice concepts and STEAM projects on mining, and aims to solidify a foundation based on justice, equity, equality, and empathy for STEM students and faculty. Our (S)TEAM made of professors in three academic departments underscores interdisciplinary and diversity connections through an interdisciplinary team-taught course, units on environmental justice related to mining, teaching of literary texts, and STEAM projects. We also involved faculty, alumni, and our campus and city community through STEAM exhibits.

Students Arts Participation Increases Stem Motivation Via Self-Efficacy, Stephen M. Dahlem

The Transdisciplinary STEAM+ Journal

This work found that there exists a correlation between student motivation in science, technology, engineering and mathematics (STEM) and student participation in the arts during high school with self-efficacy being a mediator. STEM is an important component of student success from a broad, national, perspective, as well as from a domain-specific point of view. The results of this work may provide aid to teachers, parents, administrators, and even students seeking to find ways to increase student motivation and performance in the STEM subjects. Additionally, this work may be of interest to advocates of the arts. This quantitative correlational study was …

Steam And The Way Forward, Shamini Dias

The Transdisciplinary STEAM+ Journal

The STEAM Journal editorial in which we present this issue and describe our way forward in furthering transdisciplinary thought and practice in the integration and connection of STEM and the Arts. STEAM is poised to become a critical space of thought and practice in research, education, and the arts in addressing emerging complex and global issues.

Comprehensive Wind Speed Forecasting-Based Analysis Of Stacked Stateful & Stateless Models, Swayamjit Saha, Amogu Uduka, Hunter Walt, James Lucore

Graduate Student Research Symposium

Wind speed is a powerful source of renewable energy, which can be used as an alternative to the non-renewable resources for production of electricity. Renewable sources are clean, infinite and do not impact the environment negatively during production of electrical energy. However, while eliciting electrical energy from renewable resources viz. solar irradiance, wind speed, hydro should require special planning failing which may result in huge loss of labour and money for setting up the system. In this poster, we discuss four deep recurrent neural networks viz. Stacked Stateless LSTM, Stacked Stateless GRU, Stacked Stateful LSTM and Statcked Stateful GRU which …