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Fractional Order Glucose Insulin Model With Generalized Mittag-Leffler Kernel, Ali Akgül, Muhammad Farman, Aqeel Ahmad, Adnan Khan, Siraj Zahran, Wasan Shakir Awad

Applied Mathematics & Information Sciences

In this paper, We formulate a fractional-order mathematical model for the populations of diabetic patients consist three- compartment G, X, and I. Diabetes Model is investigated with fractal-fractional operator for normal and type-1 diabetes. Also, the deterministic mathematical model for diabetes mellitus is investigated with the effect of the fractional parameters. Solutions are derived to investigate the influence of fractional operator which shows the impact of the disease for type-1 diabetes. The existence and uniqueness results of the fractional-order model are derived using fixed point theory. Simulation has been made for developed solutions of fractional order diabetes model to check …

Computational Comparative Analysis Identifies Potential Stemness-Related Markers For Mesenchymal Stromal/Stem Cells, Myret Ghabriel, Ahmed El Hosseiny, Ahmed Moustafa, Asma Amleh

Faculty Journal Articles

No abstract provided.

Minutes, March 2023, University Of Dayton. College Of Arts And Sciences

Documents of the College of Arts and Sciences Academic Affairs Committee

Minutes from organizational meeting for Academic Affairs Committee

The Role Of A Mutated Receptor, Ccrl2 And Its Correlation With A Risk Factor For Alzheimer’S Disease, Colby J. Hendrix, Christopher J. Haynie, Hunter G. Lindsay, Josue D. Gonzalez, Scott Weber

Library/Life Sciences Undergraduate Poster Competition 2023

Alzheimer’s Disease ( is the most common cause of dementia, which is the 5 th leading cause of death While the exact cause of AD is unknown, many suggest that inflammation could be a culprit 1 Inflammation is driven by our immune system A key component of inflammation is chemokine signaling These signaling molecules help guide immune cells to areas of infection and damage Cells use chemokine receptors to interact with secreted chemokines (Fig 1 Left) Some chemokine receptors are identified as atypical chemokine receptors ( because they have different functions than conventional chemokine receptors in the immune system (Fig …

Commonwealth Times 2023-03-01

Commonwealth Times, 1969-

No abstract provided.

Monarch Science Observer, Volume 16, College Of Sciences, Old Dominion University

College of Sciences Newsletter

Spring 2023, issue of Monarch Science Observer, ODU Colleges of Sciences Newsletter.

We Are ... Marshall, March 1, 2023, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Socioeconomic Factors In The Diagnosis And Treatment Of Malignant Melanoma In Hispanic Vs. Non-Hispanic Patients: A National Cancer Database (Ncdb) Study, Julia Griffin, Sarah J. Aurit, Timothy Malouff, Peter Silberstein

Department of Statistics: Faculty Publications

Background: The incidence of melanoma is rapidly increasing in the United States. There is a paucity of research of how melanoma affects the Hispanic population, the quickest growing population.

Objective: To identify and understand how socioeconomic factors affect a Hispanic patients health outcome and treatment of malignant melanoma with comparisons to white, non-Hispanic (WNH) patients.

Methods: A retrospective study utilizing the National Cancer Database (NCDB) was completed investigating Hispanic patients (n=2282) and WNH patients (n=190,469) with Stage I-IV malignant melanoma. Outcome and socioeconomic variables were identified and compared across groups. Data was analyzed with SPSS and SAS …

Morpho-Physiological And Biochemical Response Of Rice (Oryza Sativa L.) To Drought Stress: A Review, Utsav Bhandari, Aakriti Gajurel, Bharat Khadka, Ishwor Thapa, Isha Chand, Dibya Bhatta, Anju Poudel, Meena Pandey, Suraj Paudel, Jiban Shrestha

Extension Publications

Global food shortages are caused mainly by drought, the primary driver of yield loss in agriculture worldwide. Drought stress negatively impacts the physiological and morphological characteristics of rice (Oryza sativa L.), limiting the plant productivity and hence the economy of global rice production. Physiological changes due to drought stress in rice include constrained cell division and elongation, stomatal closure, loss of turgor adjustment, reduced photosynthesis, and lower yields. Morphological changes include inhibition of seed germination, reduced tillers, early maturity, and reduced biomass. In addition, drought stress leads to a metabolic alteration by increasing the buildup of …

Diversification Of The Ruminant Skull Along An Evolutionary Line Of Least Resistance., Daniel P Rhoda, Annat Haber, Kenneth D Angielczyk

Faculty Research 2023

Clarifying how microevolutionary processes scale to macroevolutionary patterns is a fundamental goal in evolutionary biology, but these analyses, requiring comparative datasets of population-level variation, are limited. By analyzing a previously published dataset of 2859 ruminant crania, we find that variation within and between ruminant species is biased by a highly conserved mammalian-wide allometric pattern, CREA (craniofacial evolutionary allometry), where larger species have proportionally longer faces. Species with higher morphological integration and species more biased toward CREA have diverged farther from their ancestors, and Ruminantia as a clade diversified farther than expected in the direction of CREA. Our analyses indicate that …

Reference Frames In Human Sensory, Motor, And Cognitive Processing, Dongcheng He

Electronic Theses and Dissertations

Reference-frames, or coordinate systems, are used to express properties and relationships of objects in the environment. While the use of reference-frames is well understood in physical sciences, how the brain uses reference-frames remains a fundamental question. The goal of this dissertation is to reach a better understanding of reference-frames in human perceptual, motor, and cognitive processing. In the first project, we study reference-frames in perception and develop a model to explain the transition from egocentric (based on the observer) to exocentric (based outside the observer) reference-frames to account for the perception of relative motion. In a second project, we focus …

Small Gtpase Regulated Intracellular Protein Trafficking In Endothelium, Caitlin Francis

Electronic Theses and Dissertations

Intracellular protein trafficking is the movement of membrane-bound organelles to and from requisite locations within the cell. Small GTPases are a critical component to the spatiotemporal accuracy of intracellular trafficking pathways as they determine the specificity and direction of organelle transport. There exists over 150 small GTPases categorized into 5 sub-families and are employed across all cell types. Despite their universal expression and relevance to cellular function, small GTPases remain incompletely understood across tissue types. In various instances, the trafficking pathway of a particular Rab in one cell type may belong to a completely disparate pathway in another cell type. …

Honors Oracle, March 2023, Marshall University Honors College

Honors Oracle

Marshall University’s Honors College newsletter.

Cc Magazine, Spring 2023, Connecticut College

Alumni News/Connecticut College Magazine

No abstract provided.

Be Like Jesus: Flip Some Tables, Jessica Easter

Intersections

No abstract provided.

Reducing Barriers, Jill B. King 98

Linfield Magazine

The Linfield community is fighting the underrepresentation of women in STEM in K-12, college and beyond

Citation: Almarwani, B.; Hamada, Y.Z.; Phambu, N.; Sunda-Meya, A. Investigating The Insertion Mechanism Of Cell-Penetrating Peptide Penetratin Into Cell Membranes: Implications For Targeted Drug Delivery. Biophysica 2023, 3, 620–635. Https://Doi.Org/ 10.3390/Biophysica3040042 Academic Editor: Herbert Schneckenburger Received: 14 October 2023 Revised: 4 November 2023 Accepted: 7 November 2023 Published: 11 November 2023 Copyright: © 2023 By The Authors. Licensee Mdpi, Basel, Switzerland. This Article Is An Open Access Article Distributed Under The Terms And Conditions Of The Creative Commons Attribution (Cc By) License (Https:// Creativecommons.Org/Licenses/By/ 4.0/).Biophysica Article Investigating The Insertion Mechanism Of Cell-Penetrating Peptide Penetratin Into Cell Membranes: Implications For Targeted Drug Delivery, Bashiyar Almarwani, Yahia Z. Hamada, Nsoki Phambu, Anderson Sunda-Meya

Chemistry Faculty Research

The cell-penetrating peptide (CPP) penetratin (PEN) has garnered attention for its potential to enter tumor cells. However, its translocation mechanism and lack of selectivity remain debated. This study investigated PEN’s insertion into healthy cells (H-) and cancer cells (C-) using micromolar concentrations and various techniques. Raman spectroscopy was used to determine PEN’s location in the lipid bilayer at different lipid-to-peptide ratios. Dynamic light scattering (DLS) and zeta potential analysis were used to measure the lipid–PEN complex’s size and charge. The results showed helical PEN particles directly inserted into C- membranes at a ratio of 110, while aggregated particles stayed on …

Caring For Your Employees, Lance Plunkett Jd, Llm

The New York State Dental Journal

Employment laws are rapidly expanding worker opportunities and rights complicating dentists' ability to hire and retain employees in a competitive job market.

Pharmacy Matters - March 2023, University Of Mississippi. School Of Pharmacy

Pharmacy Matters Newsletters

Featured stories: "Diamond Flower Compounds Show Promise in Repelling Mosquitoes," "UM Partners with Mississippi Cannabis Patients Alliance, Releaf App," "Alumni Spotlight: Erika Webster (PharmD 06)," "UM Pharmacy Hosts Purnell for Health Equity Lecture," "Help Us Help Students," "Natural Products Center Director Named AAAS, ASP Fellow"

Is There A Link Between Male Gonopodium Size And Mating Strategies Amongst Fish In The Family Poeciliidae?, Ryen Hunsaker, Jerald B. Johnson

Library/Life Sciences Undergraduate Poster Competition 2023

Have different male mating strategies led to evolutionary changes in male gonopodium size?

Natural selection should act strongly on any traits that affect successful reproduction. Fish species in the family Poeciliidae (livebearers) have a unique form of reproduction.

Identification, Validation And Biological Characterisation Of Novel Glioblastoma Tumour Microenvironment Subtypes: Implications For Precision Immunotherapy., K White, K Connor, M Meylan, A Bougoüin, M Salvucci, F Bielle, A C O'Farrell, K Sweeney, L Weng, G Bergers, P Dicker, D M Ashley, E S Lipp, J T Low, J Zhao, P Wen, R Prins, M Verreault, A Idbaih, A Biswas, J H M Prehn, D Lambrechts, I Arijs, F Lodi, G Dilcan, M Lamfers, S Leenstra, F Fabro, I Ntafoulis, J M Kros, J Cryan, F Brett, E Quissac, A Beausang, S Macnally, P O'Halloran, J Clerkin, O Bacon, A Kremer, R T Chi Yen, Frederick S Varn, Roel G W Verhaak, C Sautès-Fridman, W H Fridman, A T Byrne

Faculty Research 2023

BACKGROUND: New precision medicine therapies are urgently required for glioblastoma (GBM). However, to date, efforts to subtype patients based on molecular profiles have failed to direct treatment strategies. We hypothesised that interrogation of the GBM tumour microenvironment (TME) and identification of novel TME-specific subtypes could inform new precision immunotherapy treatment strategies.

MATERIALS AND METHODS: A refined and validated microenvironment cell population (MCP) counter method was applied to >800 GBM patient tumours (GBM-MCP-counter). Specifically, partition around medoids (PAM) clustering of GBM-MCP-counter scores in the GLIOTRAIN discovery cohort identified three novel patient clusters, uniquely characterised by TME composition, functional orientation markers and …

Ga4gh Phenopackets: A Practical Introduction., Markus S Ladewig, Julius O B Jacobsen, Alex H Wagner, Daniel Danis, Baha El Kassaby, Michael Gargano, Tudor Groza, Michael Baudis, Robin Steinhaus, Dominik Seelow, Nikolaos E Bechrakis, Christopher J Mungall, Paul N Schofield, Olivier Elemento, Lindsay Smith, Julie A Mcmurry, Monica Munoz-Torres, Melissa A Haendel, Peter N Robinson

Faculty Research 2023

The Global Alliance for Genomics and Health (GA4GH) is developing a suite of coordinated standards for genomics for healthcare. The Phenopacket is a new GA4GH standard for sharing disease and phenotype information that characterizes an individual person, linking that individual to detailed phenotypic descriptions, genetic information, diagnoses, and treatments. A detailed example is presented that illustrates how to use the schema to represent the clinical course of a patient with retinoblastoma, including demographic information, the clinical diagnosis, phenotypic features and clinical measurements, an examination of the extirpated tumor, therapies, and the results of genomic analysis. The Phenopacket Schema, together with …

The Limitations Of Privacy Rights, Daniel J. Solove

Notre Dame Law Review

Individual privacy rights are often at the heart of information privacy and data protection laws. The most comprehensive set of rights, from the European Union’s General Data Protection Regulation (GDPR), includes the right to access, right to rectification (correction), right to erasure (deletion), right to restriction, right to data portability, right to object, and right to not be subject to automated decisions. Privacy laws around the world include many of these rights in various forms.

In this Article, I contend that although rights are an important component of privacy regulation, rights are often asked to do far more work than …

Leading Law Schools In Australia, Hong Kong & Singapore Join Hands To Form Research Alliance On Law & Sustainability To Drive Research & Teaching In The Asia-Pacific Region, Singapore Management University

SMU Press Releases and News

Singapore Management University (SMU) Yong Pung How School of Law (YPHSL); Sydney Law School, University of Sydney (USyd); and Faculty of Law, The University of Hong Kong (HKU), today announced the formation of the Asia-Pacific Research Alliance on Law and Sustainability, a first of its kind in the Asia-Pacific region, with an aim to drive law-focused research and teaching initiatives on achieving sustainability for this part of the world. The announcement was made at the inaugural Law and Sustainability Conference titled ‘Law in a hyperconnected world – joining the dots for a sustainable future’. Organised by SMU YPHSL, with the …

Antimicrobial Edible Coating Composed Of Chitosan Polyvinyl Alcohol And Zinc-Coated Halloysite Nanotubes, Sindhu Datla

Master's Theses

Changes in everyday activities like food packaging are required due to the global shift from a linear to a circular economy. Therefore, industrial, and institutional research centers are interested in using biodegradable materials like polyvinyl alcohol and natural raw materials like chitosan to develop novel food packaging films. Edible coating materials have been extensively researched to extend the shelf life of fruits and vegetables and reduce the risk of ingesting chemical reagents. Chitosan (CH) is widely used as a natural preservative for fruits and vegetables, but its poor mechanical, and water resistance limits its use. To improve the properties of …

Protecting Wa Crops Issue 28 - March 2023, Department Of Primary Industries And Regional Development, Western Australia

Protecting WA Crops

Protecting WA Crops Issue 28 - March 2023 contents:

• GRDC Perth Research Updates 2023 - Entomology
• Russian wheat aphid thresholds in WA and using biological control for RLEM
• Lessons learnt from native budworm activity in wheat, relative to traditional hosts lupins, pulses and canola
• Meet Crop Protection team member – Svetlana Micic

Conventional Methods And Future Trends In Antimicrobial Susceptibility Testing, Md Abdus Salam, Md Yusuf Al-Amin, Jogendra Singh Pawar, Naseem Akhter, Irine Banu Lucy

Neurology Articles

Antimicrobial susceptibility testing is an essential task for selecting appropriate antimicrobial agents to treat infectious diseases. Constant evolution has been observed in methods used in the diagnostic microbiology laboratories. Disc diffusion or broth microdilution are classical and conventional phenotypic methods with long turnaround time and labour-intensive but still widely practiced as gold-standard. Scientists are striving to develop innovative, novel and faster methods of antimicrobial susceptibility testing to be applicable for routine microbiological laboratory practice and research. To meet the requirements, there is an increasing trend towards automation, genotypic and micro/nano technology-based innovations. Automation in detection systems and integration of computers …

March 1, 2023 Greenmail, University Of Alabama At Birmingham

GreenMail (student newsletter through 2024)

No abstract provided.

Voices Raised, Spring 2023 (20th Anniversary Special Edition), University Of Dayton. Women's Center

Women’s Center Newsletter

Newsletter editor: Catherine Forrest

In this issue:

• Looking Back, by Lisa Rismiller
• From the Director's Desk, by Leah Ward
• Education
• Research
• Action
• Next Steps & New Directions

Uncovering Zn2+ And Ca2+ Homeostasis And Crosstalk In Primary Hippocampal Neurons, Chen Zhang

Electronic Theses and Dissertations

Zn²⁺ has been suggested to act as an intracellular signaling molecule due to its regulatory effects on numerous protein targets including enzymes, transcription factors, ion channels, neurotrophic factors, and postsynaptic scaffolding proteins. However, intracellular Zn²⁺ concentration is tightly maintained at steady levels under natural physiological conditions. Dynamic changes in intracellular Zn²⁺ concentration have only been detected in cells exposed to pathologic stimuli or upon receptor ligand binding. In the first project of my dissertation, for the first time, we revealed that developing neurons fire spontaneous and synchronous Zn²⁺ spikes at a specific time window (from 14 …