Digital Commons Network^™

Nutritional Value Of Pasture Forage For Sheep In Krkonoše National Park, P. Homolka

IGC Proceedings (1977-2023)

This study describes the nutritional value of pastures in extreme mountain conditions in Krkonoše Mountains National Park. The Park performs important ecological and environmental functions. Extensive sheep grazing serves in the preservation of rare, protected and endangered species of plants (including endemics) and in the restoration of the biodiversity of meadows. The objective of this experiment was to estimate the production of plant biomass in these pastures and its digestibility by sheep.

Characterization Of Tick And Host-Associated Factors Linked To Induction Of Alpha-Gal Syndrome., Surendra Raj Sharma, Surendra Raj Sharma

Dissertations

Alpha-Gal Syndrome (AGS) is a delayed allergic reaction caused by specific IgE antibodies to the oligosaccharide galactose-α-1,3-galactose (α-gal) present in red meat. AGS is a growing concern globally, with over 34,000 confirmed cases in the United States alone. Studies have linked AGS to tick bites, which sensitizes hosts against α-gal antigens and elevates α-gal specific IgE. This dissertation investigates the role of tick and host-associated factors in AGS development. Microbiome analysis of Am. americanum ticks revealed a comprehensive core microbiome profile and showed that new Fransiella-like endosymbionts dominate and outcompete conventional tick Coxiella endosymbionts. Ticks subjected to tetracycline treatment showed …

Design And Fabrication Of Single-Chain Nanoparticles, Vitrimers, Bottlebrush And Comb Polymers, Logan Dugas

Dissertations

The introduction of novel dynamic exchange chemistries into polymer chains and networks has shown great potential of giving next generation polymeric materials. Within the scope of this thesis, dynamic chemistry is employed to realize single-chain nanoparticles, vitrimer networks, bottlebrush and comb polymers. CHAPTER I provides a broad introduction to the topics at hand, focusing upon the techniques utilized to achieve such materials with relevant literature and understanding of the techniques and architectures explored. CHAPTER II focuses upon the synthesis of single-chain nanoparticles via a copolymerization of polyisobutylene macromonomers with norbornene monomers equipped with pendant anthracene moieties. Through this work, the …

Poor Seizure Control Among Children Attending A Tertiary Hospital In South Western Uganda – A Retrospective Study, Martha Sajatovic

Faculty Scholarship

Background: Seizure control among children with epilepsy (CWE) receiving anti-seizure medications (ASMs) remains a challenge in low-resource settings. Uncontrolled seizures are significantly associated with increased morbidity and mortality among CWE. This negatively impacts their quality of life and increases stigma. Aim: This study determined seizure control status and described the factors associated among CWE receiving ASMs at Mbarara Regional Referral Hospital (MRRH). Methods: In a retrospective chart review study, socio-demographic and clinical data were obtained from 112 medical records. CWE receiving ASMs for at least six months and regularly attending the clinic were included in the study. Physical or telephone …

In Silico Binding Of 2-Aminocyclobutanones To Sars-Cov-2 Nsp13 Helicase And Demonstration Of Antiviral Activity, Thahani S. Habeeb Mohammad, Yash Gupta, Cory T. Reidl, Vlad Nicolaescu, Haley Gula, Ravi Durvasula, Prakasha Kempaiah, Daniel P. Becker Ph.D.

Chemistry: Faculty Publications and Other Works

The landscape of viral strains and lineages of SARS-CoV-2 keeps changing and is currently dominated by Delta and Omicron variants. Members of the latest Omicron variants, including BA.1, are showing a high level of immune evasion, and Omicron has become a prominent variant circulating globally. In our search for versatile medicinal chemistry scaffolds, we prepared a library of substituted α-aminocyclobutanones from an α-aminocyclobutanone synthon (11). We performed an in silico screen of this actual chemical library as well as other virtual 2-aminocyclobutanone analogs against seven SARS-CoV-2 nonstructural proteins to identify potential drug leads against SARS-CoV-2, and more broadly against coronavirus …

Isolation: The Experience Of Adolescent Motherhood In Laos, Souksamone Thongmixay, Dirk Essink, Taewee Kahrs, Viengnakhone Vongxay, Pamela Wright Phd, Ms, Med, Rn, Cen, Vanphanom Sychareun, Jacqueline E. Broerse

Publications

BACKGROUND:Teenage pregnancy is a persistent public health problem with pervasive socio-economic consequences, particularly in in low- and middle-income countries, often related to low social participation and low economic security. The experiences of adolescent pregnancy and motherhood have seldom been described from a personal point of view. This study aimed to gain insights into how adolescent mothers in Laos experience their motherhood, how they perceive their situation and try to cope with it.

METHODS: This qualitative study was undertaken with 20 pregnant adolescents and young mothers living in peri-urban areas in two of the 18 provinces in Laos. Data were collected …

Profiling Cognitive–Motor Interference In A Large Sample Of Persons With Progressive Multiple Sclerosis And Impaired Processing Speed: Results From The Cogex Study, R. Veldkamp, M. D’Hooge, B. M. Sandroff, J. Deluca, D. Kos, A. Salter, A. Feinstein, M. P. Amato, G. Brichetto, J. Chataway, R. Farrell, N. D. Chiaravalloti, U. Dalgas, M. Filippi, J. Freeman, R. W. Motl, C. Meza, M. Inglese, M. A. Rocca, G. Cutter, P. Feys

School of Health Professions

BACKGROUND: Performing cognitive-motor dual tasks (DTs) may result in reduced walking speed and cognitive performance. The effect in persons with progressive multiple sclerosis (pwPMS) having cognitive dysfunction is unknown. OBJECTIVE: To profile DT-performance during walking in cognitively impaired pwPMS and examine DT-performance by disability level. METHODS: Secondary analyses were conducted on baseline data from the CogEx-study. Participants, enrolled with Symbol Digit Modalities Test 1.282 standard deviations below normative value, performed a cognitive single task ([ST], alternating alphabet), motor ST (walking) and DT (both). Outcomes were number of correct answers on the alternating alphabet task, walking speed, and DT-cost (DTC: decline …

Long-Term Gastrointestinal Outcomes Of Covid-19, Evan Xu, Yan Xie, Ziyad Al-Aly

2020-Current year OA Pubs

A comprehensive evaluation of the risks and 1-year burdens of gastrointestinal disorders in the post-acute phase of COVID-19 is needed but is not yet available. Here we use the US Department of Veterans Affairs national health care databases to build a cohort of 154,068 people with COVID-19, 5,638,795 contemporary controls, and 5,859,621 historical controls to estimate the risks and 1-year burdens of a set of pre-specified incident gastrointestinal outcomes. We show that beyond the first 30 days of infection, people with COVID-19 exhibited increased risks and 1-year burdens of incident gastrointestinal disorders spanning several disease categories including motility disorders, acid …

The Molecular And Cellular Response To Acat1/Soat1 Inhibition, Taylor C. Harned

Dartmouth College Ph.D Dissertations

Cholesterol is an important component of all mammalian cell membranes. It governs the membrane’s physical properties and creates the membrane order and heterogeneity required for complex membrane-related processes. Tight regulation of cholesterol levels and distribution are necessary for maintaining proper cell health. Likewise, disruptions in cholesterol homeostasis have been implicated in a variety of diseases, including Alzheimer’s disease (AD). Our lab, and others, have demonstrated the benefits of blocking acyl-CoA:cholesterol acyltransferase1/sterol O:acyltransferase 1 (ACAT1/SOAT1) in AD models by genetic ablation or pharmacological inhibition. We understand that blocking ACAT1/SOAT1 activity reduces amyloid and tau pathology, and that this is, at least …

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Pov: Yes, Filling Out The Race Box On Forms Is Tiresome, But Here’S Why It Matters, Jasmine Gonzales Rose, Neda Khoshkhoo

Shorter Faculty Works

Filling out your race and ethnicity on a form may feel tiresome, and even uncomfortable. You have been checking these boxes for years, as has everyone else, and the questions may seem irrelevant.

“What does race have to do with my doctor’s appointment?” you might ask. Or a form may be inaccurate: “I’m Middle Eastern, why don’t I get a box to check?” Perhaps it feels intrusive: “How is this information going to be used?” And you may wonder, “Why are we always talking about race?”

The truth is, we need to keep talking about race. Even more than we …

Effects Of Honey Locust Seed Pods On The Behavior And Nutrient Intake Of Zoo-Housed François Langurs And Prehensile-Tailed Porcupines, Noah T. Dunham, Kaylin S. Tennant, Patricia M. Dennis

Faculty Scholarship

Seed pods represent an under-utilized and valuable dietary resource for zoos because they encourage naturalistic extractive foraging behavior and because seeds pods, like leafy browses, are more fiber-rich than most dietary items typically offered in zoos. The primary goal of this study was to examine the effects of honey locust (Gleditsia triacanthos) seed pods on the behavior and macronutrient intake of zoo-housed François’ langurs (Trachypithecus francoisi; n = 3) and prehensile-tailed porcupines (Coendou prehensilis; n = 2) using a pre- versus postdiet implementation design. From December 2019 to April 2020, we recorded behavior using instantaneous interval sampling and daily macronutrient …

Program Review Report 3-7-23, Angela Brock

Program Review Committee

No abstract provided.

The Influence Of Range Shifts And Wind Energy On The Atlantic Surfclam (Spisula Solidissima) And Ocean Quahog (Arctica Islandica) Fisheries On The U.S. Outer Continental Shelf, Stephanie Stromp

Master's Theses

The Atlantic surfclam, Spisula solidissima, is a biomass dominant bivalve of the Northwestern Atlantic. The surfclam’s historic range extended from Cape Hatteras to Georges Bank, but recent decades of warming bottom water temperatures have caused the surfclam to shift its range to cooler waters north and offshore within the range of the ocean quahog, Arctica islandica. An ecotone now exists over much of the offshore range of the surfclam in which surfclams and ocean quahogs co-occur. Regulations prohibit fishers from landing both species in the same catch, limiting fishing to locations where the target species can be sorted …

Fall/Winter 2022: Path To Princeton: Alum Takes Athletic Training Skills To Ivy League, St. Norbert College

St. Norbert College Magazine 2019-2023

Lauren Roethlisberger, an athletic trainer for Princeton University, aids women’s hockey players in their training, game-day needs and rehab.Lauren Roethlisberger ’16 parlayed her St. Norbert College athletic training experience into a role supporting Princeton University’s varsity athletes, embracing the challenges and rewards of collegiate sports medicine in the Ivy League.

Facilitating Transformative Innovations In Sustainability Education [Version 2], Martin Melin, Geir Lieblein, Tor Arvid Breland, Charles A. Francis

Department of Agronomy and Horticulture: Faculty Publications

Educational strategies globally are changing from an authoritative, top-down model to one focused on greater student and stakeholder participation in planning and implementation of research and educational activities. In addition to emphasis on student-centered education, strategies currently evolve to encompass learning organizations and multistakeholder learning networks. These are essential to address the complexity and scope of tomorrow’s challenges, involving issues that could be called ’wicked problems’ not easily addressed by single disciplines nor resulting in solutions that please all the players. In this study we describe how a transformative innovation – the NEXTFOOD educational approach – may contribute substantially to …

Independent - Mar. 7, 2023, Monty Stites

The Independent (1988-present)

No abstract provided.

Systematic Review Of Reflection Spectroscopy-Based Skin Carotenoid Assessment In Children, Saima Hasnin, Dipti Dev, Taren Swindle, Susan B. Sisson, Stephanie Jilcott Pitts, Tirna Purkait, Shari C. Clifton, Jocelyn Dixon, Virginia C. Stage

Department of Child, Youth, and Family Studies: Faculty Publications

Assessing children’s skin carotenoid score (SCS) using reflection spectroscopy (RS) is a non-invasive, widely used method to approximate fruit and vegetable consumption (FVC). The aims for the current review were to (1) identify distributions of SCS across demographic groups, (2) identify potential non-dietary correlates for RS-based SCS, (3) summarize the validity and reliability of RSbased SCS assessment, and (4) conduct meta-analyses of studies examining the correlation between RS-based SCS with FVC. A literature search in eight databases in June 2021 resulted in 4880 citations and peer-reviewed publications written in English that investigated children’s (2–10 years old) SCS using RS. We …

Ucc Meeting Minutes 4-18-23, Angela Brock

UCC Agendas/Minutes

No abstract provided.

National Co2 Budgets (2015-2020) Inferred From Atmospheric Co2 Observations In Support Of The Global Stocktake, Brendan Byrne, David F. Baker, Sourish Basu, Michael Bertolacci, Kevin W. Bowman, Dustin Carroll, Abhishek Chatterjee, Frédéric Chevallier, Philippe Ciais, Noel Cressie, David Crisp, Sean Crowell, Feng Deng, Zhu Deng, Nicholas M. Deutscher, Manvendra K. Dubey, Sha Feng, Omaira E. García, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

Accurate accounting of emissions and removals of CO₂ is critical for the planning and verification of emission reduction targets in support of the Paris Agreement. Here, we present a pilot dataset of country-specific net carbon exchange (NCE; fossil plus terrestrial ecosystem fluxes) and terrestrial carbon stock changes aimed at informing countries' carbon budgets. These estimates are based on "top-down"NCE outputs from the v10 Orbiting Carbon Observatory (OCO-2) modeling intercomparison project (MIP), wherein an ensemble of inverse modeling groups conducted standardized experiments assimilating OCO-2 column-Averaged dry-Air mole fraction (XCO₂) retrievals (ACOS v10), in situ CO₂ measurements or …

Assessment Of Largemouth Bass (Micropterus Salmoides) Condition Using Liver Histopathology, Health Parameters And Water Quality Of The Central Chattahoochee River Watershed, Kari Carmack Goodwin

Theses and Dissertations

The health of Largemouth bass from west-central Georgia was assessed using liver histopathology and the degree of tissue change index (DTC), hepatosomatic indices (HSI), relative weight, condition factors, and intersex. These health parameters as well as water chemistry data were compared across four bodies of water, three within the Chattahoochee watershed, and one pseudo-control located in the Flint watershed. Fish from Lake Oliver, Lake Harding, and West Point Lake had severely impacted liver health compared to Warm Springs National Fish Hatchery, with DTC rankings over 100 for the three lakes within the Chattahoochee watershed, demonstrating severely damaged livers. There was …

Changes In Metal-Chelating Metabolites Induced By Drought And A Root Microbiome In Wheat, Anne J. Anderson, Joshua M. Hortin, Astrid R. Jacobson, David W. Britt, Joan E. Mclean

Biological Engineering Faculty Publications

The essential metals Cu, Zn, and Fe are involved in many activities required for normal and stress responses in plants and their microbiomes. This paper focuses on how drought and microbial root colonization influence shoot and rhizosphere metabolites with metal-chelation properties. Wheat seedlings, with and without a pseudomonad microbiome, were grown with normal watering or under water-deficit conditions. At harvest, metal-chelating metabolites (amino acids, low molecular weight organic acids (LMWOAs), phenolic acids, and the wheat siderophore) were assessed in shoots and rhizosphere solutions. Shoots accumulated amino acids with drought, but metabolites changed little due to microbial colonization, whereas the active …

Uab Researcher Leads Nation's First Dental Implant Registry, Anna Jones

Browse All News

No abstract provided.

Social Science Researchers' Perceptions Of Inclusive Research Practices For Transgender And Gender Diverse Communities, Christen Seyl

Honors Program: Senior Projects (Public)

Social sciences research has historically excluded or marginalized of transgender and gender diverse (TGD) people. Although TGD affirming research materials can help improve relationships with TGD communities, these sorts of materials are not standard practice. The present study aimed to determine what factors influence social science researchers’ (SSR) willingness to incorporate affirming practices into their research. We hypothesized that more culturally competent SSR will view TGD affirming research materials as more affirming and be more willing to use similar materials in their work. In this study, SSR (n = 32) viewed and rated affirmation and willingness to use five affirming …

Multifaceted Role For P53 In Pancreatic Cancer Suppression, Stephano S Mello, Brittany M Flowers, Pawel K Mazur, James J Lee, Fabian Müller, Sarah K Denny, Sofia Ferreira, Kathryn Hanson, Seung K Kim, William J Greenleaf, Laura D Wood, Laura D Attardi

Faculty, Staff and Student Publications

The vast majority of human pancreatic ductal adenocarcinomas (PDACs) harbor TP53 mutations, underscoring p53's critical role in PDAC suppression. PDAC can arise when pancreatic acinar cells undergo acinar-to-ductal metaplasia (ADM), giving rise to premalignant pancreatic intraepithelial neoplasias (PanINs), which finally progress to PDAC. The occurrence of TP53 mutations in late-stage PanINs has led to the idea that p53 acts to suppress malignant transformation of PanINs to PDAC. However, the cellular basis for p53 action during PDAC development has not been explored in detail. Here, we leverage a hyperactive p53 variant-p5353,54-which we previously showed is a more robust PDAC suppressor than …

A Global Phylogenomic Analysis Of The Shiitake Genus Lentinula, Sean Sierra-Patev, Byoungnam Min, Miguel Naranjo-Ortiz, Brian Looney, Zachary Konkel, Jason C. Slot, Yuichi Sakamoto, Jacob L. Steenwyk, Antonis Rokas, Juan Carro, Susana Camarero, Patricia Ferreira, Gonzalo Molpeceres, Francisco J. Ruiz-Dueñas, Ana Serrano, Bernard Henrissat, Elodie Drula, Karen W. Hughes, Juan L. Mata, Noemia Kazue Ishikawa, Ruby Vargas-Isla, Shuji Ushijima, Chris A. Smith, John Donoghue, Steven Ahrendt, William Andreopoulos, Guifen He, Kurt Labutti, Anna Lipzen, Vivian Ng, Robert Riley, Laura Sandor, David Hibbett

Biology

Lentinula is a broadly distributed group of fungi that contains the cultivated shiitake mushroom, L. edodes. We sequenced 24 genomes representing eight described species and several unnamed lineages of Lentinula from 15 countries on four continents. Lentinula comprises four major clades that arose in the Oligocene, three in the Americas and one in Asia–Australasia. To expand sampling of shiitake mushrooms, we assembled 60 genomes of L. edodes from China that were previously published as raw Illumina reads and added them to our dataset. Lentinula edodes sensu lato (s. lat.) contains three lineages that may warrant recognition as species, one including …

Modeling And Computation For Unsteady Blood Flow And Solute Concentration In A Constricted Porous Artery, Daniel N. Riahi, Saulo Orizaga

School of Mathematical & Statistical Sciences Faculty Publications

We investigated a physical system for unsteady blood flow and solute transport in a section of a constricted porous artery. The aim of this study was to determine effects of hematocrit, stenosis, pulse oscillation, diffusion, convection and chemical reaction on the solute transport. The significance of this study was uncovering combined roles played by stenosis height, hematocrit, pulse oscillation period, reactive rate, blood speed, blood pressure force and radial and axial extent of the porous artery on the solute transported by the blood flow in the described porous artery. We used both analytical and computational methods to determine blood flow …

Occupational Therapists' Experience Of Using Home Adaptation And Assistive Products As Interventions For Older Individuals And Persons With Disabilities In Thailand, Peeradech Thichanpiang, Veerawat Sansri, Surachart Thongchoomsin, Sutinun Juntorn, Thitiya Wangkawan, Supatida Sorasak, Phichaya Baramee, Kannika Permpoonputtana, Chirathip Thawisuk, Chutikorn Nopparat, Anuchart Kaunnil Corresponding Author

The Qualitative Report

As Thailand becomes an aged society it is important to promote advancements in geriatric medicine to provide the best care for older individuals. The right assistive facilities and household mobility equipment are essential for everyday activities. The use of home adaptations and assistive products can maximize the quality of life for older individuals and make life more convenient for those with disabilities. This study aimed to investigate the experience of occupational therapists, using home adaptations and assistive products. An individual interview was conducted with eight occupational therapists who worked at regional hospitals and centers of excellence throughout Thailand using a …

The Role Of Academic Libraries In Research Data Management In Tertiary Institutions, David Onyeamaechi Ekeh Phd, Chidiebere Cordelia Ojemuyide Mrs., Claris N. Eze Phd, Mercy Ifunanaya Ani Phd, Ogochukwu Faith Igu Phd, Catherine Mbana Okpala Mrs., Chidiebere Kelechi Duru Phd

Library Philosophy and Practice (e-journal)

Abstract

An institution cannot exist and function properly without the presence of a library because the services provided by an academic library reflect the quality of the institution. This paper attempts to present a brief overview of the concept of library, research data, Research Data Management (RDM) and its constraints as well as the roles of academic libraries. These roles has experienced new paradigm shift, unprecedented reshaping and alterations as a result of emerging waves of information communication technology (ICT) and its accompanying sustainable and disruptive technologies. Scholars are now producing, storing and disseminating digital data in much larger volumes …

A Comprehensive And Integrative Approach To Mecp2 Disease Transcriptomics, Alexander J Trostle, Lucian Li, Seon-Young Kim, Jiasheng Wang, Rami Al-Ouran, Hari Krishna Yalamanchili, Zhandong Liu, Ying-Wooi Wan

Faculty, Staff and Students Publications

Mutations in MeCP2 result in a crippling neurological disease, but we lack a lucid picture of MeCP2's molecular role. Individual transcriptomic studies yield inconsistent differentially expressed genes. To overcome these issues, we demonstrate a methodology to analyze all modern public data. We obtained relevant raw public transcriptomic data from GEO and ENA, then homogeneously processed it (QC, alignment to reference, differential expression analysis). We present a web portal to interactively access the mouse data, and we discovered a commonly perturbed core set of genes that transcends the limitations of any individual study. We then found functionally distinct, consistently up- and …