Digital Commons Network^™

Hervs And Cancer-A Comprehensive Review Of The Relationship Of Human Endogenous Retroviruses And Human Cancers, Erik Stricker, Erin C Peckham-Gregory, Michael E Scheurer

Center for Medical Ethics and Health Policy Staff Publications

Genomic instability and genetic mutations can lead to exhibition of several cancer hallmarks in affected cells such as sustained proliferative signaling, evasion of growth suppression, activated invasion, deregulation of cellular energetics, and avoidance of immune destruction. Similar biological changes have been observed to be a result of pathogenic viruses and, in some cases, have been linked to virus-induced cancers. Human endogenous retroviruses (HERVs), once external pathogens, now occupy more than 8% of the human genome, representing the merge of genomic and external factors. In this review, we outline all reported effects of HERVs on cancer development and discuss the HERV …

Common Data Set, Georgia Southern University

Georgia Southern Common Datasets

No abstract provided.

Jenn Goodnough Earns Alumni Association Teaching Award, Communications And Marketing

Campus News Archive

No abstract provided.

Atlas Of Ticks (Acari: Argasidae, Ixodidae) In Germany: 1st Data Update, Franz Rubel, Stefan Zaenker, Alexander Weigand, Dieter Weber, Lidia Chitimia-Dobler, Olaf Kahl

Harold W. Manter Laboratory of Parasitology: Library Materials

The first data update of the atlas of ticks in Germany published in 2021 is presented here. This atlas provides maps based on georeferenced tick locations of 21 species endemic in Germany as well as three tick species that are regularly imported to Germany. The data update includes the following numbers of newly georeferenced tick locations: 17 Argas reflexus, 79 Carios vespertilionis, 2 Dermacentor marginatus, 43 Dermacentor reticulatus, 4 Haemaphysalis concinna, 3 Haemaphysalis punctata, 3 Hyalomma rufipes, 3 Ixodes apronophorus, 9 Ixodes arboricola, 1 Ixodes ariadnae, 30 Ixodes canisuga, …

Internal Capsule Microstructure Mediates The Relationship Between Childhood Maltreatment And Ptsd Following Adulthood Trauma Exposure, Samantha A. Wong, Stacey L. House, Deanna M. Barch, Et Al.

2020-Current year OA Pubs

No abstract provided.

Targeted Delivery Of Therapeutic Agents To The Mouse Brain Using A Stereotactic-Guided Focused Ultrasound Device, Zhongtao Hu, Yaoheng Yang, Dezhuang Ye, Si Chen, Yan Gong, Chinwendu Chukwu, Hong Chen

2020-Current year OA Pubs

Existing protocols of focused ultrasound (FUS) combined with microbubble-mediated blood-brain barrier (BBB) opening (FUS-BBBO) in preclinical research require expensive ultrasound equipment and complex operating procedures. We developed a low-cost, easy-to-use, and precise FUS device for small animal models in preclinical research. Here, we provide a detailed protocol for building the FUS transducer, attaching the transducer to a stereotactic frame for precise brain targeting, applying the integrated FUS device to perform FUS-BBBO in mice, and evaluating the FUS-BBBO outcome. For complete details on the use and execution of this protocol, please refer to Hu et al. (2022).

A Data-Driven Multivariate Process Monitoring Platform For Knowledge Discovery And Model Building In Industrial Applications, Estelle E. Seghers

LSU Master's Theses

In industrial chemical manufacturing processes, the amount of raw data generated can add complexity in the analysis and understanding of the process dynamics. Being able to properly interpret this data can help improve plant operation, especially regarding safety and profitability. This research has culminated in FastMan-JMP, a platform proposed for monitoring of industrial processes and optimization of the offline data-driven model-building process as part of the process monitoring workflow. FastMan-JMP is a tool developed in Python to apply various data mining and machine learning techniques quickly and easily to better understand valuable patterns and hidden trends in process data. One …

A Differentiation Roadmap Of Murine Placentation At Single-Cell Resolution, Xiangxiang Jiang, Yue Wang, Zhenyu Xiao, Long Yan, Shanshan Guo, Hao Wu, Xiaoyin Lu, Hongmei Wang

Faculty, Staff and Student Publications

The placenta is one of the most important yet least understood organs. Due to the limitations of conventional research approaches, we are still far from a comprehensive understanding of mouse placentation, especially regarding the differentiation of trophoblast lineages at the early developmental stage. To decipher cell compositions and developmental processes, we systematically profile the single-cell transcriptomes of trophoblast cells from extraembryonic tissues (embryonic day 7.5 (E7.5) and E8.5) and placentae (E9.5-E14.5) at one-day intervals. We identify distinct trophoblast cell types during mouse placentation, including unreported progenitor cells and intermediate precursor cells. An updated differentiation roadmap of mouse trophoblast lineages is …

Ferroptosis Hijacking By Mycobacterium Tuberculosis, Boyi Gan

Faculty, Staff and Student Publications

A recent study from Nature Communications reveals that Mycobacterium tuberculosis can hijack epigenetic machinery in host cells and induce host cell ferroptosis, which promotes pathogen pathogenicity and spread. These findings also suggest new therapeutic strategies to treat tuberculosis.

Protocols For Single-Cell Rna-Seq And Spatial Gene Expression Integration And Interactive Visualization, Surbhi Sona, Matthew Bradley, Angela H Ting

Faculty, Staff and Student Publications

There is a wealth of software that utilizes single-cell RNA-seq (scRNA-seq) data to deconvolve spatial transcriptomic spots, which currently are not yet at single-cell resolution. Here we provide protocols for implementing Seurat and Giotto packages to elucidate cell-type distribution in our example human ureter scRNA-seq dataset. We also describe how to create a stand-alone interactive web application using Seurat libraries to visualize and share our results. For complete details on the use and execution of this protocol, please refer to Fink et al. (2022).

A Mast Cell-Thermoregulatory Neuron Circuit Axis Regulates Hypothermia In Anaphylaxis, Chunjing Bao, Ouyang Chen, Huaxin Sheng, Jeffrey Zhang, Yikai Luo, Han Liang, Ru-Rong Ji, Soman N Abraham

Faculty, Staff and Student Publications

IgE-mediated anaphylaxis is an acute life-threatening systemic reaction to allergens, including certain foods and venoms. Anaphylaxis is triggered when blood-borne allergens activate IgE-bound perivascular mast cells (MCs) throughout the body, causing an extensive systemic release of MC mediators. Through precipitating vasodilatation and vascular leakage, these mediators are believed to trigger a sharp drop in blood pressure in humans and in core body temperature in animals. We report that the IgE/MC-mediated drop in body temperature in mice associated with anaphylaxis also requires the body's thermoregulatory neural circuit. This circuit is activated when granule-borne chymase from MCs is deposited on proximal TRPV1+ …

The Association Between Medication Use In Older Women With Early-Stage Operable Primary Breast Cancer And Decision Regarding Primary Treatment

Faculty, Staff and Student Publications

Background: Polypharmacy is one factor contributing to increased mortality, hospitalization, and adverse drug reactions in older adults. The aim of this study was to measure the prevalence of polypharmacy in a cohort of older women with early-stage operable primary breast cancer and the relationship of polypharmacy to primary treatment decision and functional status.

Methods: A total of 139 patients with a new diagnosis of early-stage operable primary breast cancer proven histologically were recruited as part of a prospective study. The average age was 77 years. Assessment using a cancer-specific Comprehensive Geriatric Assessment (CGA) tool was conducted within 6 weeks of …

Comparison Of Efficacy And Inflammatory Response To Thermoconjunctivoplasty Performed With Cautery Or Pulsed 1460 Nm Laser, Lauren Nakhleh, Stephen C Pflugfelder

Faculty, Staff and Students Publications

Conjunctivochalasis is a degenerative condition of the conjunctiva that disrupts tear distribution and causes irritation. Thermoreduction of the redundant conjunctiva is required if symptoms are not relieved with medical therapy. Near-infrared laser treatment is a more controlled method to shrink the conjunctiva than thermocautery. This study compared tissue shrinkage, histology, and postoperative inflammation in thermoconjunctivoplasty performed on the mouse conjunctiva using either thermocautery or pulsed 1460 nm near-infrared laser irradiation. Three sets of experiments were performed on female C57BL/6J mice (

Zoledronic Acid Blocks Overactive Kir6.1/Sur2-Dependent Katp Channels In Skeletal Muscle And Osteoblasts In A Murine Model Of Cantú Syndrome, Rosa Scala, Fatima Maqoud, Conor Mcclenaghan, Theresa M Harter, Maria Grazia Perrone, Antonio Scilimati, Colin G Nichols, Domenico Tricarico

2020-Current year OA Pubs

Cantú syndrome (CS) is caused by the gain of function mutations in the

Gemc1 And Mcidas Interactions With Swi/Snf Complexes Regulate The Multiciliated Cell-Specific Transcriptional Program, Michael Lewis, Tao Cheng, Moe R Mahjoub, Et Al.

2020-Current year OA Pubs

Multiciliated cells (MCCs) project dozens to hundreds of motile cilia from their apical surface to promote the movement of fluids or gametes in the mammalian brain, airway or reproductive organs. Differentiation of MCCs requires the sequential action of the Geminin family transcriptional activators, GEMC1 and MCIDAS, that both interact with E2F4/5-DP1. How these factors activate transcription and the extent to which they play redundant functions remains poorly understood. Here, we demonstrate that the transcriptional targets and proximal proteomes of GEMC1 and MCIDAS are highly similar. However, we identified distinct interactions with SWI/SNF subcomplexes; GEMC1 interacts primarily with the ARID1A containing …

A Long-Term Study Of Sex Differences In Attitudes Towards Women’S Roles In The Military And In Combat, Edward F. Murphy Jr., Regina A. Greenwood

Journal of the North American Management Society

This study explored changes in attitudes towards women’s roles in society, particularly the military, from 1993 to 2004 using the Spence, Helmreich and Stapp (1973) Attitudes towards Women scale. The researchers surveyed 500 respondents in 1993 and 2,560 between 2002 and 2004, finding that, while both women and men became more equalitarian, women became even more equalitarian. Although both men and women believe that women belong in the military, female respondents felt that women would be just as good as men in combat while men felt that women should not be in combat occupations. The study concludes that traditional stereotypes …

Examining Uranium Mining In The Canyon Mine, Kasha Halbleib

Pace Environmental Law Review

In November 2020, Energy Fuels changed the name of one of its uranium mines from “Canyon Mine” to “Pinyon Plain Mine” in order to put distance between the mine and its historical controversies. However, changing the name does not change the potential harm the mine can cause. Canyon Mine sits fifteen miles from the rim of the Grand Canyon and is built on land sacred to the nearby Havasupai Tribe. The mine stands to not only destroy the health and well-being of the Havasupai people by contaminating their water supply with radioactive elements, but also to destroy the sacred ties …

Conference Program

Women's Summit Presented by Bryant University

Conference Program for the 2023 Women's Summit presented by Bryant University. Program has schedule for the day, information about the keynote speakers, and list of sponsors.

The Thrush Sings Me Home: What Is Killing The Birds Of My Heart?, Amy Boyd

Appalachia

Amy Boyd writes of her heartbreak seeing dead wood thrushes in her town. Habitat destruction and climate change will reduce these beautiful birds’ numbers by 80 percent over the next 60 years.

The Chanticleer, 2023-03-16, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

"Flexible As A Librarian". How To Manage A Medium-Size Medical Library, Witold Kozakiewicz

IATUL 2023 Slides

Medical University of Lodz is the largest medical school in Poland. The Information and Library Centre, with about 30 employees, is considered a medium-sized academic library by local standards. Being a medical library, we face several tasks that are less common in other types of libraries. Besides providing services for students and organizing e-resources for academic staff, we are involved in the research process, taking part in Systematic Reviews (SR), cooperating with the University and Hospital administration to prepare data for Hospital Based Health Technology Assessment (HB-HTA) analyses. Other tasks include managing the CRIS system, which provides key data for …

Recognizing Exploitation And Rejecting Analogy: An Analysis Of The Meat-Commodity, Teddy Duncan Jr.

Between the Species

This paper is a two-part project. First, I reject the analogous relationship between the Holocaust and slaughterhouses (found in the anti-meat novel The Lives of Animals) and cross-species analogical thinking entirely; instead, I opt for modes of analysis that can examine the specific circumstances of animals within slaughterhouses. Secondly, I assert that a socio-economic Marxist analysis is the best prism in which to recognize the suffering of pre-slaughter animals and the causation of their suffering (the ostensibly necessary circulation and production of the meat-commodity).

2023.03.16 - Academic/Student Affairs, Enrollment, And Technology Committee Meeting Miutes, Northeastern Illinois University Board Of Trustees

Board of Trustees - 2023

Meeting materials for the NEIU Academic/Student Affairs, Enrollment, and Technology Committee

Narrative Review: The Fda’S Perfunctory Approach Of Dietary Supplement Regulations Giving Rise To Copious Reports Of Adverse Events, Weiqi Li, Albert Wertheimer

HPD Articles

Background: The Food and Drug Administration (FDA) originated from the passage of the 1906 Pure Food and Drugs act aimed to rein in the long-standing abuse in the consumer product marketplace. The act was passed to prohibit interstate commerce of misbranded and adulterated foods, drinks, drugs. Thus, promoting the FDA’s mission to protect the public health by regulating human and veterinary drugs, biological products, medical devices, food supply, cosmetics, and tobacco to ensure safety, efficacy, and security. Progressing further in 1994, the Dietary Supplement Health and Education Act (DSHEA) was established designating specific label requirements, providing regulatory framework, and authorizing …

Application Of Convergent Science And Technology Toward Ocular Disease Treatment, Ayca Bal-Ozturk, Ece Ozcan-Bulbul, Hazal Ezgi Gultekin, Berivan Cecen, Ebru Demir, Atefeh Zarepout, Sibel Cetinel, Ali Zarrabi

Henry M. Rowan College of Engineering Departmental Research

Eyes are one of the main critical organs of the body that provide our brain with the most information about the surrounding environment. Disturbance in the activity of this informational organ, resulting from different ocular diseases, could affect the quality of life, so finding appropriate methods for treating ocular disease has attracted lots of attention. This is especially due to the ineffectiveness of the conventional therapeutic method to deliver drugs into the interior parts of the eye, and the also presence of barriers such as tear film, blood-ocular, and blood-retina barriers. Recently, some novel techniques, such as different types of …

Coping With Captivity: The Tragic Journey Of Willie B., Terry Maple

Tales of WellBeing

This tale is the first in a three-part series about Willie B., Atlanta’s iconic ape and one of the most famous gorillas in the world.

The Student Movement Volume 107 Issue 19: A Weekend To Remember: Aunited Showcases Cultural Diversity, Grace No, Nora Martin, Anna Pak, Gio Lee, Aiko J. Ayala Rios, Andrew Francis, Alannah Tjhatra, Reagan Mccain, Gabriela Francisco, Katie Davis, Lexie Dunham, Wambui Karanja, Kayla-Hope Bruno

The Student Movement v. 107 (2022-2023)

HUMANS

Andrews Students Discuss Feminism, Interviewed by: Grace No

Honors Scholars and Undergraduate Research Poster Symposium: Meet the Researchers, Nora Martin

Public vs Private Schooling?, Interviewed by: Anna Pak

ARTS & ENTERTAINMENT

Creatives on Campus: Women's History Month, Gio Lee

See My World: AU Composers' Recital, Aiko J. Ayala Rios

Sonnets Reimagined: English 430 Collage Projects, Grace No

NEWS

Cultural Clubs Wow During Preview Showcase, Andrew Francis

Head in the Clouds: The AUnited Cultural Gala, Alannah Tjhatra

Honors Scholars and Undergraduate Research Poster Symposium 2023, Nora Martin

IDEAS

A Kinda Brief History of Feminism, Reagan McCain

Bee Kind!, Gabriela Francisco …

The Minutes Of The Marshall University Staff Council Meeting, March 2023, Marshall University Staff Council

Staff Council Minutes

No abstract provided.

The Montclarion, March 16, 2023, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

2023 Academic & Creative Excellence Reception Program, Lynn University

Academic and Creative Excellence (ACE) Reception Programs

The program for the 2023 Academic and Creative Excellence (ACE) Reception - the 15th annual - organized by the Lynn Library, working in conjunction with the Office of Academic Affairs. The reception is held on March 16, 2023 in the Keith C. and Elaine Johnson Wold Performing Arts Center.

The Faculty Scholarship and Creative Activities Award is presented to Dr. Begum Kaplan.