Digital Commons Network^™

Helpful Or Harmful? A Case Report Of Nutritional Supplements Causing Drug-Induced Liver Injury, Amman Bhasin, Md, Phoebe Chun, Md, Justin Bilello, Md, Manju Ambelil, Md, Dina L. Halegoua-Demarzio, Md

The Medicine Forum

Herbal supplement-induced liver injury represents a growing concern in the body of drug-induced liver injury (DILI) literature, with recent studies in mainland China, Iceland, and the United States reporting estimated rates of herb/dietary supplement-induced liver injury (HILI) between 1.16-6.38 per 100,000 (Björnsson et al., 2013; Shen et al., 2019; Vega et al., 2017). Notably, a recent 2020 study demonstrated an increasing prevalence of hepatotoxicity secondary to herbal and dietary supplements in the US and worldwide (Zheng et al., 2020). Recognizing the hepatotoxicity of various supplements is crucial, given the increasing usage of dietary and herbal supplements and the lack of …

The Medicine Forum: Volume 24

The Medicine Forum

The Journal of Thomas Jefferson University Hospital - Department of Internal Medicine, Volume 24, 2022-2023

TABLE OF CONTENTS

• Case Reports
• Ultrasound Education

Personality As A Predictor Of Hitting And Pitching Performances Among Professional Baseball Players, Tess M. Palmateer, Trent A. Petrie, Whitney Moore

Journal of Athlete Development and Experience

Research regarding personality as predictors of objective physical performances has been limited and equivocal. We examined longitudinally whether personality predicted baseball pitchers’ (n = 119) or hitters’ (n = 115) performances after controlling for past performances. Through regression analyses, we determined that personality did not significantly predict the player’ performances during their first year in Minor League Baseball (MiLB). Our results indicate that, at least in the short-term, personality may be a poor predictor of such performances. Research is needed to determine if personality’s effects may occur over a longer period of time, such as through the development …

A Mechanistic Evaluation Of Naturally Occurring Igf1r 3’Utr Gene Variants Altering Disease Outcomes In Women, Theron Niel

Natural Sciences and Mathematics | Biological Sciences Master's Theses

The insulin-like growth factor (IGF) axis, including its IGF1R receptor and IGF-1 ligand, is evolutionarily conserved and essential for normal organismal growth, development, and longevity. However, when dysregulated, this IGF growth axis can also drive disease and cancer development. In the human genome there are many naturally occurring IGF axis gene variants, especially within the IGF1R gene locus. A subset of these variants are single nucleotide polymorphisms (SNPs), and while none of these are known to be pathogenic, some (like rs2016347) are considered functional given their location within the IGF1R 3’ untranslated region (UTR), where they can potentially control tissue …

Taking Flight: North By South, Tallgrass Prairie Center, University Of Northern Iowa

Open Educational Resources

Lesson adapted form the book Keepers of the Earth : Native American stories and environmental activities for children by Michael J. Caduto and Joseph Bruchac focusing on the migration of birds and the flyways in North America for grades 6 through 8.

Tree Peeps, Tallgrass Prairie Center, University Of Northern Iowa

Open Educational Resources

Lesson adapted form the book Keepers of the Earth : Native American stories and environmental activities for children by Michael J. Caduto and Joseph Bruchac focusing on conservation and land stewardship for grades 7 through 12.

Nature Blanks, Tallgrass Prairie Center, University Of Northern Iowa

Open Educational Resources

An outline of an activity for grades Kindergarten through 8 for students to make a picture of a item in nature.

Sindrom Respons Inflamasi Sistemik, Yefta Moenadjat

Department of Surgery Teaching Materials and Monographs

Materi perkuliahan memuat uraian respons inflamasi pascatrauma yang berkembang menjadi sindrom respons inflamasi sistemik, berakhir dengan kegagalan organ multipel ditinjau dari aspek biomolekuler.

Buku ini merupakan bagian pertama dari seri inflamasi yang disusun dalam bentuk digital dan dipublikasi menurut konsep lisensi Commons Attribution-NonCommercial 4.0 International License untuk tujuan diseminasi.

2023 Coordinated Spring Survey Of Mid-Continent Sandhill Cranes, Terry Liddick

United States Fish and Wildlife Service: Publications

The aerial transect portion of the coordinated spring survey of mid-continent Sandhill cranes was conducted on March 22, 2023 in Nebraska’s Central Platte and North Platte River valleys (United States). The 2023 photo-corrected aerial estimate is 1,259,000 birds. Outside the traditional aerial transect portion, observers conducted ground surveys during the period March 20–22. From these regions, observers in the Official Survey Area (OSA) of Nebraska, Kansas, Texas, Oklahoma, and Wyoming reported an additional 25,363 cranes. The 2023 total estimate (1,284,500) increased 43.1% from 2022. The current three-year average (2021–2023 with no photo correction in 2021), based on photo corrected estimates …

Genetically Diverse Mouse Models Of Sars-Cov-2 Infection Reproduce Clinical Variation In Type I Interferon And Cytokine Responses In Covid-19., Shelly J Robertson, Olivia Bedard, Kristin L Mcnally, Carl Shaia, Chad S Clancy, Matthew Lewis, Rebecca M Broeckel, Abhilash I Chiramel, Jeffrey G Shannon, Gail L Sturdevant, Rebecca Rosenke, Sarah L Anzick, Elvira Forte, Christoph Preuss, Candice N Baker, Jeffrey M. Harder, Catherine Brunton, Steven C. Munger, Daniel P Bruno, Justin B Lack, Jacqueline M Leung, Amirhossein Shamsaddini, Paul Gardina, Daniel E Sturdevant, Jian Sun, Craig Martens, Steven M Holland, Nadia Rosenthal, Sonja M Best

Faculty Research 2023

Inflammation in response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection drives severity of coronavirus disease 2019 (COVID-19) and is influenced by host genetics. To understand mechanisms of inflammation, animal models that reflect genetic diversity and clinical outcomes observed in humans are needed. We report a mouse panel comprising the genetically diverse Collaborative Cross (CC) founder strains crossed to human ACE2 transgenic mice (K18-hACE2) that confers susceptibility to SARS-CoV-2. Infection of CC x K18-hACE2 resulted in a spectrum of survival, viral replication kinetics, and immune profiles. Importantly, in contrast to the K18-hACE2 model, early type I interferon (IFN-I) and regulated …

Cytochrome P450 Gene Families: Role In Plant Secondary Metabolites Production And Plant Defense, Panchali Chakraborty, Ashok Biswas, Susmita Dey, Tuli Bhattacharjee, Swapan Chakrabarty

Michigan Tech Publications

Cytochrome P450s (CYPs) are the most prominent family of enzymes involved in NADPH- and O2-dependent hydroxylation processes throughout all spheres of life. CYPs are crucial for the detoxification of xenobiotics in plants, insects, and other organisms. In addition to performing this function, CYPs serve as flexible catalysts and are essential for producing secondary metabolites, antioxidants, and phytohormones in higher plants. Numerous biotic and abiotic stresses frequently affect the growth and development of plants. They cause a dramatic decrease in crop yield and a deterioration in crop quality. Plants protect themselves against these stresses through different mechanisms, which are accomplished by …

Smokejumper Obituary: Jemmett, Coy Grant (Mccall 1963), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Port Hamilton Refining And Transportation Lllp V. Epa

2023 Decisions

Agency

Center For Biological Diversit V. Epa

2023 Decisions

Agency

The Combined Effects Of Discrimination And Holding Multiple Intersecting Marginalized Identities On Substance Use Among Adolescents, Ashley Thomas

Theses and Graduate Projects

Individuals with multiple intersecting marginalized identities may be at greater risk for negative outcomes and exposure to discrimination during development. The aim of this study was to investigate the effects of discrimination and having multiple marginalized identities on substance use among Minnesota youth. Using data gathered from the 2019 administration of the Minnesota Student Survey, a large statewide survey of 80,456 9th and 11th grade students, this study aimed to identify how holding multiple intersecting identities related to experiences of discrimination and substance use in Minnesota youth. Findings revealed that participants with more marginalized identity statuses experienced higher rates of …

Thieno[3,4-D]Pyrimidin-4(3h)-Thione: An Effective, Oxygenation Independent, Heavy-Atom-Free Photosensitizer For Cancer Cells, Luis A. Ortiz-Rodríguez, Sean J. Hoehn, Heather J. Folkwein, Liraz Levi, Carlos E. Crespo-Hernández

Faculty Scholarship

All-organic, heavy-atom-free photosensitizers based on thionation of nucleobases are receiving increased attention because they are easy to make, noncytotoxic, work both in the presence and absence of molecular oxygen, and can be readily incorporated into DNA and RNA. In this contribution, the DNA and RNA fluorescent probe, thieno[3,4-d]pyrimidin-4(1H)-one, has been thionated to develop thieno[3,4-d]pyrimidin-4(3H)-thione, which is nonfluorescent and absorbs near-visible radiation with about 60% higher efficiency. Steady-state absorption and emission spectra are combined with transient absorption spectroscopy and CASPT2 calculations to delineate the electronic relaxation mechanisms of both pyrimidine derivatives in aqueous and acetonitrile solutions. It is demonstrated that thieno[3,4-d]pyrimidin-4(3H)-thione …

Global And Tissue-Specific Aging Effects On Murine Proteomes., Gregory R Keele, Ji-Gang Zhang, John Szpyt, Ron Korstanje, Steven P Gygi, Gary Churchill, Devin K Schweppe

Faculty Research 2023

Maintenance of protein homeostasis degrades with age, contributing to aging-related decline and disease. Previous studies have primarily surveyed transcriptional aging changes. To define the effects of age directly at the protein level, we perform discovery-based proteomics in 10 tissues from 20 C57BL/6J mice, representing both sexes at adult and late midlife ages (8 and 18 months). Consistent with previous studies, age-related changes in protein abundance often have no corresponding transcriptional change. Aging results in increases in immune proteins across all tissues, consistent with a global pattern of immune infiltration with age. Our protein-centric data reveal tissue-specific aging changes with functional …

Understanding Veteran Perceptions About Mental Health And Its Treatment, Quinn Turner Stoddard

Dissertations and Theses

Mental health illnesses are a growing issue for a large part of the country, and veterans in particular are vulnerable to the numerous negative effects they pose. Despite the high number of people that may benefit from treatment, a variety of issues with trust, stigma, and attitudes may act as barriers to care utilization. In response, this study investigated the perceptions that veterans within the Pacific Northwest hold in regards to mental health treatment as well as their intentions to seek it out should they require it. Using the integrated model of behavioral prediction (IMBP), data was gathered about veterans’ …

The Impact Of Climate Change On Selected Pnw Watersheds Through The Lens Of Western Red Cedar Habitat, Jordan T. Hamann

Dissertations and Theses

Climate change is a real phenomenon that is exacerbating existing natural processes and developing into a new normal for the planet. This change may be devastating for Pacific Northwest populations of Western Red Cedar (WRC) west of the Cascade Mountain range in the states of Oregon and Washington. WRC is a valuable tree species for reasons both economic and cultural. Dieback among WRC is following an accelerating trend. Since dieback is usually followed by tree mortality, understanding its causes and distribution is beneficial to the overall success of the species going into the future.

Through the use of ESRI's ArcGIS …

Cambrian Explosion Condensed: High-Precision Geochronology Of The Lower Wood Canyon Formation, Nevada, Lyle L. Nelson, James L. Crowley, Emily F. Smith, Darin M. Schwartz, Eben B. Hodgin, Mark D. Schmitz

Geosciences Faculty Publications and Presentations

The geologically rapid appearance of fossils of modern animal phyla within Cambrian strata is a defining characteristic of the history of life on Earth. However, temporal calibration of the base of the Cambrian Period remains uncertain within millions of years, which has resulted in mounting challenges to the concept of a discrete Cambrian explosion. We present precise zircon U–Pb dates for the lower Wood Canyon Formation, Nevada. These data demonstrate the base of the Cambrian Period, as defined by both ichnofossil biostratigraphy and carbon isotope chemostratigraphy, was younger than 533 Mya, at least 6 My later than currently recognized. This …

Modulating Water Distribution And The Intramicellar Assembly Of Sequence-Defined Ionic Peptoid Block Copolymers By The Ionic Monomer Position, Bailee N. Barrett, Chi Huan Tung, Guan Rong Huang, Istiak Hossain, Chang Woo Do, Vijay T. John, Wei Ren Chen, Donghui Zhang

Faculty Publications

The intramicellar mass heterogeneity of a series of sequence-defined ionic peptoid block copolymers carrying a single charged monomer has been determined through contrast variation small-angle neutron scattering analysis. We observe that the internal micellar structure, namely, the number density radial distributions of invasive water and peptoid polymer, is significantly impacted by the location of the ionic monomer. By positioning the ionic monomer progressively closer to the hydrophilic/hydrophobic block junction, the micelles become less compact with increasing levels of chain folding and invasive water to accommodate electrostatic repulsion among the ionic monomers via solvation. This results in increasingly smaller micellar aggregates …

Early Chromosome Condensation By Xist Builds A-Repeat Rna Density That Facilitates Gene Silencing, M. Valledor, M. Byron, B. Dumas, Dawn M. Carone, L. L. Hall, J. B. Lawrence

Biology Faculty Works

XIST RNA triggers chromosome-wide gene silencing and condenses an active chromosome into a Barr body. Here, we use inducible human XIST to examine early steps in the process, showing that XIST modifies cytoarchitecture before widespread gene silencing. In just 2–4 h, barely visible transcripts populate the large “sparse zone” surrounding the smaller “dense zone”; importantly, density zones exhibit different chromatin impacts. Sparse transcripts immediately trigger immunofluorescence for H2AK119ub and CIZ1, a matrix protein. H3K27me3 appears hours later in the dense zone, which enlarges with chromosome condensation. Genes examined are silenced after compaction of the RNA/DNA territory. Insights into this come …

Interiority And Agency: Exploring Self In Context With Others In The Act Of Creation, Barbara Young

Interiority

This investigation seeks to extend the discourse on interiority. I am an interior designer and, therefore, pose questions as they relate to design process, specifically that the concern regarding interiority is not necessarily something to design for, but as designers, it affects how and what we design. The presented cases are artistic explorations that provided an opportunity to interrogate interiority as it relates to my cognitive and creative process. Through an auto-ethnographic account, I present two acts of making. In the creation process, I interrogate meaning-making and perception that constitutes my subjective interiority, which can only be understood in context. …

Harnessing Autoimmunity With Dominant Self-Peptide: Modulating The Sustainability Of Tissue-Preferential Antigen-Specific Tregs By Governing The Binding Stability Via Peptide Flanking Residues, Youwei Lin, Shun Sakuraba, Chandirasegaran Massilamany, Jayagopala Reddy, Yoshimasa Tanaka, Sachiko Miyake, Takashi Yamamura

School of Veterinary and Biomedical Sciences: Faculty Publications

Sensitization to self-peptides induces various immunological responses, from autoimmunity to tumor immunity, depending on the peptide sequence; however, the underlying mechanisms remain unclear, and thus, curative therapeutic options considering immunity balance are limited. Herein, two overlapping dominant peptides of myelin proteolipid protein, PLP136-150 and PLP139-151, which induce different forms of experimental autoimmune encephalomyelitis (EAE), monophasic and relapsing EAE, respectively, were investigated. Mice with monophasic EAE exhibited highly resistant to EAE re-induction with any encephalitogenic peptides, whereas mice with relapsing EAE were susceptible, and progressed, to EAE re-induction. This resistance to relapse and reinduction in monophasic EAE mice was associated with …

Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites – Field Sampling Plan (Fsp) Bres No. 31 – Waste Dump #5, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites – Field Sampling Plan (Fsp) Bres No. 174 – Buffalo South And Bres No 174 – Buffalo Ditch, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites – Field Sampling Plan (Fsp) Bres No. 17 – Paymaster, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Nanoparticle-Based Treatment Approaches For Skin Cancer: A Systematic Review., Michael Joseph Diaz, Nicole Natarelli, Shaliz Aflatooni, Sarah J. Aleman

School of Medicine Faculty Publications

Nanoparticles have shown marked promise as both antineoplastic agents and drug carriers. Despite strides made in immunomodulation, low success rates and toxicity remain limitations within the clinical oncology setting. In the present review, we assess advances in drug delivery nanoparticles, for systemic and topical use, in skin cancer treatment. A systematic review of controlled trials, meta-analyses, and Cochrane review articles was conducted. Eligibility criteria included: (1) a primary focus on nanoparticle utility for skin cancer; (2) available metrics on prevention and treatment outcomes; (3) detailed subject population; (4) English language; (5) archived as full-text journal articles. A total of 43 …

Membrane Stretch As The Mechanism Of Activation Of Piezo1 Ion Channels In Chondrocytes, Alireza Savadipour, Robert J Nims, Neda Rashidi, Jaquelin M Garcia-Castorena, Ruhang Tang, Gabrielle K Marushack, Sara J Oswald, Wolfgang B Liedtke, Farshid Guilak

2020-Current year OA Pubs

Osteoarthritis is a chronic disease that can be initiated by altered joint loading or injury of the cartilage. The mechanically sensitive PIEZO ion channels have been shown to transduce injurious levels of biomechanical strain in articular chondrocytes and mediate cell death. However, the mechanisms of channel gating in response to high cellular deformation and the strain thresholds for activating PIEZO channels remain unclear. We coupled studies of single-cell compression using atomic force microscopy (AFM) with finite element modeling (FEM) to identify the biophysical mechanisms of PIEZO-mediated calcium (Ca

Propofol Inhibits Glioma Stem Cell Growth And Migration And Their Interaction With Microglia Via Bdnf-As And Extracellular Vesicles, Rephael Nizar, Simona Cazacu, Cunli Xiang, Matan Krasner, Efrat Barbiro-Michaely, Doron Gerber, Jonathan Schwartz, Iris Fried, Shira Yuval, Aharon Brodie, Gila Kazimirsky, Naama Amos, Ron Unger, Stephen L. Brown, Lisa Rogers, Donald H. Penning, Chaya Brodie

Neurosurgery Articles

Glioblastoma (GBM) is the most common and aggressive primary brain tumor. GBM contains a small subpopulation of glioma stem cells (GSCs) that are implicated in treatment resistance, tumor infiltration, and recurrence, and are thereby considered important therapeutic targets. Recent clinical studies have suggested that the choice of general anesthetic (GA), particularly propofol, during tumor resection, affects subsequent tumor response to treatments and patient prognosis. In this study, we investigated the molecular mechanisms underlying propofol's anti-tumor effects on GSCs and their interaction with microglia cells. Propofol exerted a dose-dependent inhibitory effect on the self-renewal, expression of mesenchymal markers, and migration of …