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2023

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Editorial: Rock Physics Modeling And Well-Log Practice For Unconventional Reservoirs, Qiaomu Qi, Lidong Dai, Maxim Lebedev, Tobias Müller, Junfang Zhang Jan 2023

Editorial: Rock Physics Modeling And Well-Log Practice For Unconventional Reservoirs, Qiaomu Qi, Lidong Dai, Maxim Lebedev, Tobias Müller, Junfang Zhang

Research outputs 2022 to 2026

Unconventional resources with commercial interest in the world mainly include heavy oils, shales, coalbed methane and tight gas sands. The production and development of these resources have changed the supply pattern of global energy. Quantitative interpretation of geophysical data in the exploration, well logging and engineering development of the unconventional resources requires a comprehensive understanding of the physical properties of rocks and their relationships. The research of rock physics provides an interdisciplinary treatment of physical properties, whether it is highly related to geological, geophysical and geomechanical methodologies. The development of new rock physics methods is essential when integrating core, well-log, …

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Gaze Behaviour, Body Image In Women And Online Apparel Shopping, Ross C. Hollett, Peta M. Panaia, Aimee H. Smart Jan 2023

Gaze Behaviour, Body Image In Women And Online Apparel Shopping, Ross C. Hollett, Peta M. Panaia, Aimee H. Smart

Research outputs 2022 to 2026

Online apparel shopping is popular among women, with possible negative body image consequences, particularly when the website imagery is body-focused. We investigated both correlational and experimental effects of online apparel shopping on women's (N = 113) explicitly and implicitly measured self-worth, appearance attitudes and body gaze behaviour. Self-reported online apparel shopping behaviour positively correlated with self-objectification and a tendency to value and compare one's appearance. Following a simulated online shopping activity, women who browsed a body-focused activewear website felt worse about their looks, when compared with women who browsed a non-body-focused casualwear website. The activewear condition also primed lower subsequent …

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How General Practitioners And Patients Discuss Type 2 Diabetes Mellitus And Cardiovascular Diseases Concerns During Consultations: Implications For Digital Health, Urvashi Rohilla, Jayashanthi P. Ramarao, Jared Lane, Neha N. Khatri, James Smith, Kathleen Yin, Annie Y. S. Lau Jan 2023

How General Practitioners And Patients Discuss Type 2 Diabetes Mellitus And Cardiovascular Diseases Concerns During Consultations: Implications For Digital Health, Urvashi Rohilla, Jayashanthi P. Ramarao, Jared Lane, Neha N. Khatri, James Smith, Kathleen Yin, Annie Y. S. Lau

Research outputs 2022 to 2026

Objective: To analyse general practitioner–patient consultations about type 2 diabetes mellitus or cardiovascular diseases and describe (i) the nature of self-management discussions; (ii) actions required from patients during and after consultation regarding self-management; and (iii) implications for digital health to support patients during (and after) consultation. Method: This study screened 281 general practitioner consultations conducted in 2017 within the UK general practice setting from an existing dataset containing videos and transcripts of consultations between GPs and patients. Secondary analysis was conducted using a multi-method approach, including descriptive, content, and visualisation analysis, to inform the nature of self-management discussions, what actions …

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In The Search For Greener Buildings: The Role Of Green Human Resource Management, Subhadarsini Parida, Christopher Chan, Subramaniam Ananthram, Kerry Brown Jan 2023

In The Search For Greener Buildings: The Role Of Green Human Resource Management, Subhadarsini Parida, Christopher Chan, Subramaniam Ananthram, Kerry Brown

Research outputs 2022 to 2026

The environmental performance of green buildings is receiving attention from built environment stakeholders. We introduce the concept of green human resource management (GHRM) to analyze how the performance gap in green buildings can be minimized using a human-focused design perspective. We utilize signaling theory and abilities–motivation–opportunity (AMO) theory to explain the interactions between environmental proactivity, GHRM, pro-environmental behaviors, job performance, and environmental performance. Survey data were collected from 460 employees working in Leadership in Energy and Environmental Design (LEED)-certified green buildings in India and analyzed using structural equation modeling (SEM). Findings highlight that GHRM is likely to motivate employees to …

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It's Quite Good Fun: A Qualitative Study Of A Singing/Songwriting Programme For People With Parkinson's Disease And Their Spouses, Deborah Hersh, Shi J. Kong, Jessica Smith Jan 2023

It's Quite Good Fun: A Qualitative Study Of A Singing/Songwriting Programme For People With Parkinson's Disease And Their Spouses, Deborah Hersh, Shi J. Kong, Jessica Smith

Research outputs 2022 to 2026

Background: : Group singing for people with Parkinson's disease (PD) is an established intervention not only to improve voice and speech difficulties but also for emotional and social benefit. Less is known about the experiences of group singing on the couple—the person with PD and their spouse or partner together—and studies have not specifically tracked impact through time or in combination with songwriting. Aims: : To understand the impact of group singing/songwriting on couples (participants with PD and their spouses) to unpack whether this broader view might help explain why such interventions are reported as beneficial. Using a trajectory approach, …

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Mapping The Leap: Differences In Quality Improvement In Relation To Assessment Rating Outcomes, Belinda Davis, Rosemary Dunn, Linda J. Harrison, Manjula Waniganayake, Fay Hadley, Rebecca Andrews, Hui Li, Susan Irvine, Lennie Barblett, Maria Hatzigianni Jan 2023

Mapping The Leap: Differences In Quality Improvement In Relation To Assessment Rating Outcomes, Belinda Davis, Rosemary Dunn, Linda J. Harrison, Manjula Waniganayake, Fay Hadley, Rebecca Andrews, Hui Li, Susan Irvine, Lennie Barblett, Maria Hatzigianni

Research outputs 2022 to 2026

Introduction: Australia’s National Quality Standard (NQS) outlines the criteria to assess the quality of early childhood services. A four-point rating scale: (i) Exceeding NQS; (ii) Meeting NQS; (iii) Working Toward NQS; and (iv) Significant Improvement Required is applied to services following a regular assessment and rating process. Settings rated as Working Toward are reassessed within 12 months. Most settings achieved a one-step improvement in this Time 2 reassessment, moving to a Meeting rating but some settings made a two-step improvement, moving to an Exceeding rating. The QIP is a key document used by authorities to assess the quality of a …

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Men And Women Differ In Their Interest And Willingness To Participate In Exercise And Sports Science Research, James L. Nuzzo, Robert O. Deaner Jan 2023

Men And Women Differ In Their Interest And Willingness To Participate In Exercise And Sports Science Research, James L. Nuzzo, Robert O. Deaner

Research outputs 2022 to 2026

Unequal proportions of male and female participants in exercise research might be attributed, in part, to differences in interest and willingness to participate. We tested if men and women are equally interested and willing to undergo exercise research procedures and if they consider different factors when deciding to participate. Two samples completed an online survey. Sample 1 (129 men, 227 women) responded to advertisements on social media and survey-sharing websites. Sample 2 (155 men, 504 women) was comprised of undergraduate psychology students. In both samples, men were significantly more interested to learn their muscle mass amount, running speed, jump height, …

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Overview Of Muscle Fatigue Differences Between Maximal Eccentric And Concentric Resistance Exercise, James L. Nuzzo, Matheus D. Pinto, Kazunori Nosaka Jan 2023

Overview Of Muscle Fatigue Differences Between Maximal Eccentric And Concentric Resistance Exercise, James L. Nuzzo, Matheus D. Pinto, Kazunori Nosaka

Research outputs 2022 to 2026

Since the 1970s, researchers have studied a potential difference in muscle fatigue (acute strength loss) between maximal eccentric (ECCmax) and concentric (CONmax) resistance exercise. However, a clear answer to whether such a difference exists has not been established. Therefore, the aim of our paper was to overview methods and results of studies that compared acute changes in muscle strength after bouts of ECCmax and CONmax resistance exercise. We identified 30 relevant studies. Participants were typically healthy men aged 20–40 years. Exercise usually consisted of 40–100 isokinetic ECCmax and CONmax repetitions of the knee extensors or elbow flexors. Both ECCmax and …

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Time-Out For Well-Being: A Mixed Methods Evaluation Of Attitudes And Likelihood To Engage In Different Types Of Online Emotional Well-Being Programmes In The Perinatal Period, Jacqueline A. Davis, Amy L. Finlay-Jones, Natasha Bear, Susan L. Prescott, Desiree T. Silva, Jeneva L. Ohan Jan 2023

Time-Out For Well-Being: A Mixed Methods Evaluation Of Attitudes And Likelihood To Engage In Different Types Of Online Emotional Well-Being Programmes In The Perinatal Period, Jacqueline A. Davis, Amy L. Finlay-Jones, Natasha Bear, Susan L. Prescott, Desiree T. Silva, Jeneva L. Ohan

Research outputs 2022 to 2026

Background: Positive maternal mental health during the perinatal period contributes to general well-being and positive emotional bonds with the child, encouraging an optimal developmental trajectory. Online interventions to enhance maternal well-being and develop coping skills, such as meditation-based interventions, can be a low-cost way to improve mother and child outcomes. However, this depends on end-user engagement. To date, there is limited evidence about women’s willingness to engage and preferences for online programmes. Objectives: This study explored pregnant women’s attitudes towards and likelihood to undertake minimal online well-being training programmes (mindfulness, self-compassion, or general relaxation), engagement barriers and enablers, and programme …

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Walking Journeys Into Everyday Climatic-Affective Atmospheres: The Emotional Labour Of Balancing Grief And Hope, Petra Tschakert, Chantal B. Du Coudray, Pierre Horwitz Jan 2023

Walking Journeys Into Everyday Climatic-Affective Atmospheres: The Emotional Labour Of Balancing Grief And Hope, Petra Tschakert, Chantal B. Du Coudray, Pierre Horwitz

Research outputs 2022 to 2026

The postapocalypse as a mobilising discourse for climate action operates largely out of anger over experienced and anticipated injustices as well as paradoxical hope that fuses loss and grief with freed-up solidarities in support of liveable futures. However, negotiating this emotional tension can be both draining and isolating. Here, we examine how white settler populations in Western Australia balance grief and hope in places they hold dear and the role emotions such as sadness, worry, disappointment, joy, and pride play in relational place making. Through an innovative in situ and mobile methodology we call Walking Journeys, we trace how participants …

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Circulating Lipocalin-2 And Features Of Metabolic Syndrome In Community-Dwelling Older Women: A Cross-Sectional Study, Carlie Bauer, Marc Sim, Richard L. Prince, Kun Zhu, Ee M. Lim, Elizabeth Byrnes, Nathan Pavlos, Wai H. Lim, Germaine Wong, Joshua R. Lewis, Itamar Levinger Jan 2023

Circulating Lipocalin-2 And Features Of Metabolic Syndrome In Community-Dwelling Older Women: A Cross-Sectional Study, Carlie Bauer, Marc Sim, Richard L. Prince, Kun Zhu, Ee M. Lim, Elizabeth Byrnes, Nathan Pavlos, Wai H. Lim, Germaine Wong, Joshua R. Lewis, Itamar Levinger

Research outputs 2022 to 2026

Lipocalin-2 (LCN2) is released by several cell types including osteoblasts and adipocytes and has been suggested as a marker of renal dysfunction, metabolic syndrome (MetS) and type 2 diabetes (T2D). Whether LCN2 is linked to these diseases in older women remains unknown. This study investigated whether LCN2 is related to features of MetS and T2D in older women. This cross-sectional study included 705 non-diabetic women (mean age 75.1 ± 2.6 years) for MetS analysis and 76 women (mean age 75.4 ± 2.8 years) with T2D. Total circulating LCN2 levels were analysed using a two-step chemiluminescent microparticle monoclonal immunoassay. MetS was …

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The Toy Brick As A Communicative Device For Amplifying Children’S Voices In Research, Kylie J. Stevenson, Emma Jayakumar, Harrison See Jan 2023

The Toy Brick As A Communicative Device For Amplifying Children’S Voices In Research, Kylie J. Stevenson, Emma Jayakumar, Harrison See

Research outputs 2022 to 2026

This article arises from recent industry-partner research between the ARC Centre of Excellence for the Digital Child, the LEGO Group, and Edith Cowan University (ECU), examining new ways of communicating children’s perspectives of digital citizenship to policy makers and industry in a project called Digital Safety and Citizenship Roundtables: Using Consultation and Creativity to Engage Stakeholders (Children, Policy Influencers, Industry) in Best Practice in India, South Korea, and Australia. We posed the research question: What are children’s everyday experiences of digital citizenship in these countries, and how might these contribute to digital citizenship policy and practice? In research roundtables, we …

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Experimental Assessment Of Hole Quality And Tool Condition In The Machining Of An Aerospace Alloy, Muhammad Aamir, Aamer Sharif, Muhammad Z. Zahir, Khaled Giasin, Majid Tolouei-Rad Jan 2023

Experimental Assessment Of Hole Quality And Tool Condition In The Machining Of An Aerospace Alloy, Muhammad Aamir, Aamer Sharif, Muhammad Z. Zahir, Khaled Giasin, Majid Tolouei-Rad

Research outputs 2022 to 2026

This paper deals with an experimental investigation of hole quality in Al2024-T3, which is one of the aerospace alloys used in aircraft fuselage skin due to its high level of resistance to fatigue crack propagation. The experiments are conducted with 6 mm uncoated carbide and HSS drill bits using a CNC machine under dry conditions and different drilling parameters. The characteristics of the hole quality are investigated in terms of its perpendicularity, cylindricity, circularity and hole size. An ANOVA (analysis of variance) and Pareto charts are used to analyze the effects of the drilling parameters on the hole quality. The …

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Inelastic Behavior Of Steel And Composite Frame Structure Subjected To Earthquake Loading, P. D. Gajbhiye, Nuha S. Mashaan, V. Bhaiya, Rajan L. Wankhade, S. P. Vishnu Jan 2023

Inelastic Behavior Of Steel And Composite Frame Structure Subjected To Earthquake Loading, P. D. Gajbhiye, Nuha S. Mashaan, V. Bhaiya, Rajan L. Wankhade, S. P. Vishnu

Research outputs 2022 to 2026

Steel construction is used more often these days as an alternative to the R.C.C. when lightweight, high-strength, large-span structures with a faster erection are required. Extensive studies have been conducted by researchers to study the seismic performance of reinforced concrete and steel structures, both in terms of elastic and inelastic behavior. Composite construction is also a recent advancement in the building industry with similar advantages. However, no emphasis has been given to the comparison between the inelastic behavior of steel and composite structures when subjected to lateral loads. This study compares the inelastic behavior of steel and a composite frame …

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Unrecognized Hypertension Among A General Adult Ghanaian Population: An Urban Community-Based Cross-Sectional Study Of Prevalence And Putative Risk Factors Of Lifestyle And Obesity Indices, Enoch O. Anto, Wina I. O. Boadu, Emmanuel E. Korsah, Ezkiel Ansah, Eric Adua, Joseph Frimpong, Patience Nyarkoa, Valentine C. K. T. Tamakloe, Emmanuel Acheampong, Evans A. Asamoah, Stephen Opoku, Ebenezer Afrifa-Yamoah, Max E. Annani-Akollor, Christian Obirikorang Jan 2023

Unrecognized Hypertension Among A General Adult Ghanaian Population: An Urban Community-Based Cross-Sectional Study Of Prevalence And Putative Risk Factors Of Lifestyle And Obesity Indices, Enoch O. Anto, Wina I. O. Boadu, Emmanuel E. Korsah, Ezkiel Ansah, Eric Adua, Joseph Frimpong, Patience Nyarkoa, Valentine C. K. T. Tamakloe, Emmanuel Acheampong, Evans A. Asamoah, Stephen Opoku, Ebenezer Afrifa-Yamoah, Max E. Annani-Akollor, Christian Obirikorang

Research outputs 2022 to 2026

Hypertension (HTN) is the leading cause of cardiovascular diseases. Nevertheless, most individuals in developing countries are unaware of their blood pressure status. We determined the prevalence of unrecognized hypertension and its association with lifestyle factors and new obesity indices among the adult population. This community-based study was conducted among 1288 apparently healthy adults aged 18–80 years in the Ablekuma North Municipality, Ghana. Sociodemographic, lifestyle characteristics, blood pressure and anthropometric indices were obtained. The prevalence of unrecognized HTN was 18.4% (237 / 1288). The age groups 45–54 years [aOR = 2.29, 95% CI (1.33–3.95), p = 0.003] and 55–79 years [aOR …

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Vitamin K-1 Intake And Incident Diabetes In The Danish Diet, Cancer, And Health Study, Pratik Pokharel, Jamie W. Bellinge, Frederik Dalgaard, Kevin Murray, Marc Sim, Bu B. Yeap, Emma Connolly, Lauren C. Blekkenhorst, Catherine P. Bondonno, Joshua R. Lewis, Gunnar Gislason, Anne Tjønneland, Kim Overvad, Jonathan M. Hodgson, Carl Schultz, Nicola P. Bondonno Jan 2023

Vitamin K-1 Intake And Incident Diabetes In The Danish Diet, Cancer, And Health Study, Pratik Pokharel, Jamie W. Bellinge, Frederik Dalgaard, Kevin Murray, Marc Sim, Bu B. Yeap, Emma Connolly, Lauren C. Blekkenhorst, Catherine P. Bondonno, Joshua R. Lewis, Gunnar Gislason, Anne Tjønneland, Kim Overvad, Jonathan M. Hodgson, Carl Schultz, Nicola P. Bondonno

Research outputs 2022 to 2026

Context: Observational studies have reported lower risks of type 2 diabetes with higher vitamin K1 intake, but these studies overlook effect modification due to known diabetes risk factors. Objective: To identify subgroups that might benefit from vitamin K1 intake, we examined associations between vitamin K1 intake and incident diabetes overall and in subpopulations at risk of diabetes. Methods: Participants from the prospective cohort, the Danish Diet, Cancer, and Health Study, with no history of diabetes were followed up for diabetes incidence. The association between intake of vitamin K1, estimated from a food frequency questionnaire completed at baseline, and incident diabetes …

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What Do Mathematics Lessons Look Like? Analyses Of Primary Students’ Drawings, Benjamin Rott, Laura Barton, Vesife Hatisaru Jan 2023

What Do Mathematics Lessons Look Like? Analyses Of Primary Students’ Drawings, Benjamin Rott, Laura Barton, Vesife Hatisaru

Research outputs 2022 to 2026

The use of student drawings to assess their experiences and beliefs about teaching and learning of mathematics has become almost a regular research method – especially when working with young students who may not express themselves well, for example, in self-report questionnaires. These methods, nevertheless, need to be improved regarding their objectivity and validity. By building on the existing research, in this study, we focus on objectivity and validity issues in drawing-based methods. We use a drawing-based instrument: Draw A Mathematics Classroom (DAMC) and present 104 fourth-grade students to draw a picture of their regular mathematics lessons. We especially aim …

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Invisible Women: Gender Representation In High School Science Courses Across Australia, Kathryn Ross, Shanika Galaudage, Tegan Clark, Nataliea Lowson, Andrew Battisti, Helen Adam, Alexandra K. Ross, Nici Sweaney Jan 2023

Invisible Women: Gender Representation In High School Science Courses Across Australia, Kathryn Ross, Shanika Galaudage, Tegan Clark, Nataliea Lowson, Andrew Battisti, Helen Adam, Alexandra K. Ross, Nici Sweaney

Research outputs 2022 to 2026

The visibility of female role models in science is vital for engaging and retaining women in scientific fields. In this study, we analyse four senior secondary science courses delivered across the states and territories in Australia: Biology, Chemistry, Environmental Science, and Physics. We compared male and female representation within the science courses by examining the mentions of male and female scientists along with the context of their inclusions in the syllabuses. We find a clear gender bias with only one unique mention of a female scientist. We also find a clear Eurocentric focus and narrow representation of scientists. This bias …

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Role Of Air Staging In A Batch-Type Fixed Bed Biomass Combustor Under Constant Primary Air, Awais Junejo, Yasir M. Al-Abdeli, Jacobo Porteiro Jan 2023

Role Of Air Staging In A Batch-Type Fixed Bed Biomass Combustor Under Constant Primary Air, Awais Junejo, Yasir M. Al-Abdeli, Jacobo Porteiro

Research outputs 2022 to 2026

Staged combustion of biomass is the most suitable thermo-chemical conversion for achieving lower gaseous emissions and higher fuel conversion rates. In a staged fixed bed combustion of biomass, combustion air is supplied in two stages. In the first stage, primary air is provided below the fuel, whereas in the later stage, secondary air is supplied in the freeboard region. The available literature on the effects of air staging (secondary air location) at a constant primary air flow rate on combustion characteristics in a batch-type fixed bed combustor is limited and hence warrants further investigations. This study resolves the effect of …

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An Artificial Therapist (Manage Your Life Online) To Support The Mental Health Of Youth: Co-Design And Case Series, Aimee-Rose Wrightson-Hester, Georgia Anderson, Joel Dunstan, Peter M. Mcevoy, Christopher J. Sutton, Bronwyn Myers, Sarah Egan, Sara Tai, Melanie Johnston-Hollitt, Wai Chen, Tom Gedeon, Warren Mansell Jan 2023

An Artificial Therapist (Manage Your Life Online) To Support The Mental Health Of Youth: Co-Design And Case Series, Aimee-Rose Wrightson-Hester, Georgia Anderson, Joel Dunstan, Peter M. Mcevoy, Christopher J. Sutton, Bronwyn Myers, Sarah Egan, Sara Tai, Melanie Johnston-Hollitt, Wai Chen, Tom Gedeon, Warren Mansell

Research outputs 2022 to 2026

Background: The prevalence of child and adolescent mental health issues is increasing faster than the number of services available, leading to a shortfall. Mental health chatbots are a highly scalable method to address this gap. Manage Your Life Online (MYLO) is an artificially intelligent chatbot that emulates the method of levels therapy. Method of levels is a therapy that uses curious questioning to support the sustained awareness and exploration of current problems. Objective: This study aimed to assess the feasibility and acceptability of a co-designed interface for MYLO in young people aged 16 to 24 years with mental health problems. …

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Editorial: Sleep, Vigilance & Disruptive Behaviors, Osman S. Ipsiroglu, Gerhard Klösch, Rosalia C. Silvestri, Susan M. Mccabe, Georg Dorffner, Thomas C. Wetter, Luci Wiggs Jan 2023

Editorial: Sleep, Vigilance & Disruptive Behaviors, Osman S. Ipsiroglu, Gerhard Klösch, Rosalia C. Silvestri, Susan M. Mccabe, Georg Dorffner, Thomas C. Wetter, Luci Wiggs

Research outputs 2022 to 2026

The Frontiers in Psychiatry Research Theme of Sleep, vigilance, and disruptive behaviors has two aims: first, to promote the understanding of the connections between vigilance and disruptive daytime behavior in the context of sleep deprivation and, second, to explore how naturalistic observations and pattern recognition can play a role in furthering our understanding of these connections. . . .

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Risky Business: Policy Legacy And Gender Inequality In Australian Opera Production, Caitlin Vincent, Katya Johanson, Bronwyn Coate Jan 2023

Risky Business: Policy Legacy And Gender Inequality In Australian Opera Production, Caitlin Vincent, Katya Johanson, Bronwyn Coate

Research outputs 2022 to 2026

The field of cultural policy has seen a shift towards considerations of diversity, with government bodies increasingly leveraging funding to combat inequality within organisations. A barrier to this aim is a lack of quantitative data, which would provide a means to evaluate the impact of specific policies in practice. This article investigates the relationship between gender inequality at an organisational level and cultural policy at a sectoral level through a case study of Australia’s state-funded opera companies. Drawing on production data from 2005 to 2020, we consider women’s representation as conductors, directors, and designers at the state companies through the …

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Sixteen-Year Longitudinal Evaluation Of Blood-Based Dna Methylation Biomarkers For Early Prediction Of Alzheimer's Disease, Fernanda Schäfer Hackenhaar, Maria Josefsson, Annelie Nordin Adolfsson, Mattias Landfors, Karolina Kauppi, Tenielle Porter, Lidija Milicic, Simon M. Laws, Magnus Hultdin, Rolf Adolfsson, Sofie Degerman, Sara Pudas, Australian Imaging Biomarkers And Lifestyle Study Jan 2023

Sixteen-Year Longitudinal Evaluation Of Blood-Based Dna Methylation Biomarkers For Early Prediction Of Alzheimer's Disease, Fernanda Schäfer Hackenhaar, Maria Josefsson, Annelie Nordin Adolfsson, Mattias Landfors, Karolina Kauppi, Tenielle Porter, Lidija Milicic, Simon M. Laws, Magnus Hultdin, Rolf Adolfsson, Sofie Degerman, Sara Pudas, Australian Imaging Biomarkers And Lifestyle Study

Research outputs 2022 to 2026

BACKGROUND: DNA methylation (DNAm), an epigenetic mark reflecting both inherited and environmental influences, has shown promise for Alzheimer's disease (AD) prediction. OBJECTIVE: Testing long-term predictive ability ( > 15 years) of existing DNAm-based epigenetic age acceleration (EAA) measures and identifying novel early blood-based DNAm AD-prediction biomarkers. METHODS: EAA measures calculated from Illumina EPIC data from blood were tested with linear mixed-effects models (LMMs) in a longitudinal case-control sample (50 late-onset AD cases; 51 matched controls) with prospective data up to 16 years before clinical onset, and post-onset follow-up. Novel DNAm biomarkers were generated with epigenome-wide LMMs, and Sparse Partial Least Squares …

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Detection Of Metastases Using Circulating Tumour Dna In Uveal Melanoma, Aaron B. Beasley, Daniël P. De Bruyn, Leslie Calapre, Zeyad Al-Ogaili, Timothy W. Isaacs, Jacqueline Bentel, Anna L. Reid, Roy S. Dwarkasing, Michelle R. Pereira, Muhammad A. Khattak, Tarek M. Meniawy, Michael Millward, Erwin Brosens, Annelies De Klein, Fred K. Chen, Emine Kiliҫ, Elin S. Gray Jan 2023

Detection Of Metastases Using Circulating Tumour Dna In Uveal Melanoma, Aaron B. Beasley, Daniël P. De Bruyn, Leslie Calapre, Zeyad Al-Ogaili, Timothy W. Isaacs, Jacqueline Bentel, Anna L. Reid, Roy S. Dwarkasing, Michelle R. Pereira, Muhammad A. Khattak, Tarek M. Meniawy, Michael Millward, Erwin Brosens, Annelies De Klein, Fred K. Chen, Emine Kiliҫ, Elin S. Gray

Research outputs 2022 to 2026

Background: Approximately 50% of uveal melanoma (UM) patients will develop metastatic disease depending on the genetic features of the primary tumour. Patients need 3–12 monthly scans, depending on their prognosis, which is costly and often non-specific. Circulating tumour DNA (ctDNA) quantification could serve as a test to detect and monitor patients for early signs of metastasis and therapeutic response. Methods: We assessed ctDNA as a biomarker in three distinct UM cohorts using droplet-digital PCR: (A) a retrospective analysis of primary UM patients to predict metastases; (B) a prospective analysis of UM patients after resolution of their primary tumour for early …

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Hybrid Warfare And Disinformation: A Ukraine War Perspective, Sascha-Dominik Dov Bachmann, Dries Putter, Guy Duczynski Jan 2023

Hybrid Warfare And Disinformation: A Ukraine War Perspective, Sascha-Dominik Dov Bachmann, Dries Putter, Guy Duczynski

Research outputs 2022 to 2026

Misinformation, disinformation and mal information are part of the information disorder construct, dominating the information warfare domain. These are key enablers associated with grey zone operations, and an integral part of current adversaries' and competitors' hybrid warfare tool kit. Disinformation, in combination with influence operations, also plays an important role within the concept of hybrid warfare; both from a threat–and own resilience perspective. This article reflects on these information warfare tools and their application by Russia in the current Russo-Ukraine war, offering potentially considerable force multipliers in the information domain for the Russian aggressor. Hybrid warfare and associated threats, specifically …

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Kind Regards: Negotiating Connection To Country And Place Through Collective Storying, Wendy Somerville, Vahri Mckenzie, Lisa Fuller, Naomi Joy Godden, Ashley Harrison, Renae Isaacs-Guthridge, Bethaney Turner Jan 2023

Kind Regards: Negotiating Connection To Country And Place Through Collective Storying, Wendy Somerville, Vahri Mckenzie, Lisa Fuller, Naomi Joy Godden, Ashley Harrison, Renae Isaacs-Guthridge, Bethaney Turner

Research outputs 2022 to 2026

Within this paper we explore the process and outcomes of a year-long exchange that investigates how active learning can emerge through collective place-based storying. Beginning with Country as our guide, we shared, responded, yarned, listened and revisited one another's contributions. Using the "threads"of an extended email exchange and online yarning sessions, we wove together this collaborative work to present findings generated from the creative practice of storying and sharing knowledge. This work required ongoing openness to vulnerability; we resisted the urge to remain silent and risked being wrong. Our responses, and the writing styles reflecting them, incorporate both academic and …

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Parental Perceptions Of Social And Emotional Well-Being Of Young Children From Australian Military Families, Marg Rogers, Amy Johnson, Yumiko Coffey, Jill Fielding, Ingrid Harrington, Navjot Bhullar Jan 2023

Parental Perceptions Of Social And Emotional Well-Being Of Young Children From Australian Military Families, Marg Rogers, Amy Johnson, Yumiko Coffey, Jill Fielding, Ingrid Harrington, Navjot Bhullar

Research outputs 2022 to 2026

Introduction: Many Australian Defence Force (ADF) and Veteran families are affected by the stressors of Defence family life, including frequent and prolonged parental deployments, and frequent relocations. Objective: To address a gap in information about Defence and Veteran (hereafter Defence) parents' knowledge, confidence and resources to support their young children's well-being and build their resilience. Design: This study used a mixed methods design to explore Defence parent's perceptions of their young children's (aged 2–8 years) social and emotional well-being and understanding of their children's responses to unique stressors as well as their confidence in providing support. Data from 41 parents …

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Prednisolone For Copd Exacerbations: Time For A Rethink, Sanjay Ramakrishnan Jan 2023

Prednisolone For Copd Exacerbations: Time For A Rethink, Sanjay Ramakrishnan

Research outputs 2022 to 2026

Prednisolone given universally for COPD exacerbations causes harm without any benefit. Patients deserve blood eosinophil-guided prednisolone treatment for COPD exacerbations.

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Systemic Treatment Of Advanced And Metastatic Urothelial Cancer: The Landscape In Australia, Howard Gurney, Timothy D. Clay, Niara Oliveira, Shirley Wong, Ben Tran, Carole Harris Jan 2023

Systemic Treatment Of Advanced And Metastatic Urothelial Cancer: The Landscape In Australia, Howard Gurney, Timothy D. Clay, Niara Oliveira, Shirley Wong, Ben Tran, Carole Harris

Research outputs 2022 to 2026

The 5-year survival rate of metastatic urothelial carcinoma (mUC) is estimated to be as low as 5%. Currently, systemic platinum-based chemotherapy followed by avelumab maintenance therapy is the only first-line treatment for mUC that has an overall survival benefit. Cisplatin-based chemotherapy (usually in combination with gemcitabine) is the preferred treatment but carboplatin is substituted where contraindications to cisplatin exist. Treatment with immune checkpoint inhibitors, antibody-drug conjugates, and kinase inhibitors has not yet demonstrated superiority to chemotherapy as first-line therapy and remains investigational in this setting. A recent media release indicates that chemotherapy plus nivolumab gives an OS advantage as first-line …

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Uncertainties In Wave-Driven Longshore Sediment Transport Projections Presented By A Dynamic Cmip6-Based Ensemble, Amin Reza Zarifsanayei, José A.A. Antolínez, Nick Cartwright, Amir Etemad-Shahidi, Darrell Strauss, Gil Lemos, Alvaro Semedo, Rajesh Kumar, Mikhail Dobrynin, Adem Akpinar Jan 2023

Uncertainties In Wave-Driven Longshore Sediment Transport Projections Presented By A Dynamic Cmip6-Based Ensemble, Amin Reza Zarifsanayei, José A.A. Antolínez, Nick Cartwright, Amir Etemad-Shahidi, Darrell Strauss, Gil Lemos, Alvaro Semedo, Rajesh Kumar, Mikhail Dobrynin, Adem Akpinar

Research outputs 2022 to 2026

In this study four experiments were conducted to investigate uncertainty in future longshore sediment transport (LST) projections due to: working with continuous time series of CSIRO CMIP6-driven waves (experiment #1) or sliced time series of waves from CSIRO-CMIP6-Ws and CSIRO-CMIP5-Ws (experiment #2); different wave-model-parametrization pairs to generate wave projections (experiment #3); and the inclusion/exclusion of sea level rise (SLR) for wave transformation (experiment #4). For each experiment, a weighted ensemble consisting of offshore wave forcing conditions, a surrogate model for nearshore wave transformation and eight LST models was used. The results of experiment # 1 indicated that the annual LST …

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