Digital Commons Network^™

Multi-Omic Association Study Identifies Dna Methylation-Mediated Genotype And Smoking Exposure Effects On Lung Function In Children Living In Urban Settings, Matthew Dapas, Michelle A. Gill, Et Al

2020-Current year OA Pubs

Impaired lung function in early life is associated with the subsequent development of chronic respiratory disease. Most genetic associations with lung function have been identified in adults of European descent and therefore may not represent those most relevant to pediatric populations and populations of different ancestries. In this study, we performed genome-wide association analyses of lung function in a multiethnic cohort of children (n = 1,035) living in low-income urban neighborhoods. We identified one novel locus at the TDRD9 gene in chromosome 14q32.33 associated with percent predicted forced expiratory volume in one second (FEV1) (p = 2.4x10-9; βz = -0.31, …

A Novel Biosignature Identifies Patients With Dcis With High Risk Of Local Recurrence After Breast Conserving Surgery And Radiation Therapy, Frank A Vicini, G Bruce Mann, Chirag Shah, Sheila Weinmann, Michael C Leo, Pat Whitworth, Rachel Rabinovitch, Mylin A Torres, Julie A Margenthaler, David Dabbs, Jess Savala, Steven C Shivers, Karuna Mittal, Fredrik Wärnberg, Troy Bremer

2020-Current year OA Pubs

PURPOSE: There is an unmet need to identify women diagnosed with ductal carcinoma in situ (DCIS) with a low risk of in-breast recurrence (IBR) after breast conserving surgery (BCS), which could omit radiation therapy (RT), and also to identify those with elevated IBR risk remaining after BCS plus RT. We evaluated a novel biosignature for a residual risk subtype (RRt) to help identify patients with elevated IBR risk after BCS plus RT.

METHODS AND MATERIALS: Women with DCIS treated with BCS with or without RT at centers in the US, Australia, and Sweden (n = 926) were evaluated. Patients were …

The Mutational Landscape In Chronic Myelomonocytic Leukemia And Its Impact On Allogeneic Hematopoietic Cell Transplantation Outcomes: A Center For Blood And Marrow Transplantation Research (Cibmtr) Analysis, Matthew Mei, Ravi Vij, Et Al.

2020-Current year OA Pubs

Somatic mutations are recognized as an important prognostic factor in chronic myelomonocytic leukemia (CMML). However, limited data are available regarding their impact on outcomes after allogeneic hematopoietic cell transplantation (HCT). In this registry analysis conducted in collaboration with the Center for International Blood and Marrow Transplantation Registry database/sample repository, we identified 313 adult patients with CMML (median age: 64 years, range, 28- 77) who underwent allogeneic HCT during 2001-2017 and had an available biospecimen in the form of a peripheral blood sample obtained prior to the start of conditioning. In multivariate analysis, a CMML-specific prognostic scoring system (CPSS) score of …

Factors Associated With Persistent Postsurgical Pain After Total Knee Or Hip Joint Replacement: A Systematic Review And Meta-Analysis, Arunangshu Ghoshal, Shivam Bhanvadia, Som Singh, Lauren Yaeger, Simon Haroutounian

2020-Current year OA Pubs

Studies have identified demographic, clinical, psychosocial, and perioperative variables associated with persistent pain after a variety of surgeries. This study aimed to perform a systematic review and meta-analysis of factors associated with persistent pain after total knee replacement (TKR) and total hip replacement (THR) surgeries. To meet the inclusion criteria, studies were required to assess variables before or at the time of surgery, include a persistent postsurgical pain (PPSP) outcome measure at least 2 months after a TKR or THR surgery, and include a statistical analysis of the effect of the risk factor(s) on the outcome measure. Outcomes from studies …

Pregnancy-Induced Differential Expression Of Sars-Cov-2 And Influenza A Viral Entry Factors In The Lower Respiratory Tract, Tusar Giri, Santosh Panda, Arvind Palanisamy

2020-Current year OA Pubs

Despite differences in the clinical presentation of coronavirus disease-19 and pandemic influenza in pregnancy, fundamental mechanistic insights are currently lacking because of the difficulty in recruiting critically ill pregnant subjects for research studies. Therefore, to better understand host-pathogen interaction during pregnancy, we performed a series of foundational experiments in pregnant rats at term gestation to assess the expression of host entry factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus (IAV) and genes associated with innate immune response in the lower respiratory tract. We report that pregnancy is characterized by a decrease in host factors mediating …

Adherence To And Experiences Of K-12 Students In Modified And Standard Home Quarantine During The Sars-Cov-2 Pandemic In Missouri, Mary Claire Worrell, Sara Malone, Patrick Dawson, Stephanie A. Fritz, Ebony Thomas, Bre Peeler, Catherine Rains, Sarah C. Tinker, John C. Neatherlin, Lisa Barrios, Jon Mooney, Katie Towns, Jason Newland, Johanna S. Salzer

2020-Current year OA Pubs

BACKGROUND: In November 2020, during the SARS-CoV-2 pandemic, Missouri allowed local public health jurisdictions the option to implement a modified quarantine policy allowing kindergarten through 12 (K-12) students with low-risk exposures to continue in-person learning. We assessed adherence to quarantine among participants in modified quarantine and standard home quarantine and the psychosocial impacts of quarantine on students and families.

METHODS: In January-March 2021, as part of an investigation of in-school transmission of SARS-CoV-2, parents of 586 participating K-12 students identified as a close contact with a person with SARS-CoV-2 were sent a survey to assess their activities and psychosocial impacts …

X-Ray And Mr Contrast Bearing Nanoparticles Enhance The Therapeutic Response Of Image-Guided Radiation Therapy For Oral Cancer, Gayatri Sharma, Mir Hadi Razeghi Kondelaji, Guru P. Sharma, Christopher Hansen, Abdul K. Parchur, Shayan Shafiee, Jaidip M. Jagtap, Brian Fish, Carmen Bergom, Eric Paulson, William A. Hall, Heather A. Himburg, Amit Joshi

2020-Current year OA Pubs

INTRODUCTION: Radiation therapy for head and neck squamous cell carcinoma is constrained by radiotoxicity to normal tissue. We demonstrate 100 nm theranostic nanoparticles for image-guided radiation therapy planning and enhancement in rat head and neck squamous cell carcinoma models.

METHODS: PEG conjugated theranostic nanoparticles comprising of Au nanorods coated with Gadolinium oxide layers were tested for radiation therapy enhancement in 2D cultures of OSC-19-GFP-luc cells, and orthotopic tongue xenografts in male immunocompromised Salt sensitive or SS rats via both intratumoral and intravenous delivery. The radiation therapy enhancement mechanism was investigated.

RESULTS: Theranostic nanoparticles demonstrated both X-ray/magnetic resonance contrast in a …

Public Health Product Hops, Michael S. Sinha

All Faculty Scholarship

Pharmaceutical product hops are anticompetitive maneuvers that often represent a last-ditch effort by brand manufacturers to preserve market share in the face of generic competition. An integral part of product life cycle management strategies, product hops may offer marginal benefits to patients but can substantially increase costs to payers and patients alike. Yet industry advocates maintain that this is essential follow-on research and development, resulting in the development of novel products that would otherwise never reach the market.

Is there a middle ground between these two diametrically opposed views? Might certain product hops be considered beneficial, perhaps if they furthered …

Human Rights And Lawyer’S Oaths, Lauren E. Bartlett

All Faculty Scholarship

Each lawyer in the United States must take an oath to be licensed to practice law. The first time a lawyer takes this oath is usually a momentous occasion in their career, marked by ceremony and celebration. Yet, many lawyer’s oaths today are unremarkable and irrelevant to modern law practice at best, and at worst, inappropriate, discriminatory, and obsolete. Drawing on a fifty-state survey of lawyer’s oaths in the United States, this article argues that it is past time to update lawyer’s oaths in the United States and suggests drawing on human rights to make lawyer’s oaths more accessible and …

The Psychology Of Science Denialism And Lessons For Public Health Authorities, Brenna Moreno, Molly J. Walker Wilson

All Faculty Scholarship

As it wreaked tragedy on the world, the outbreak of COVID-19 helped expose a pandemic of a different kind, one steeped in distrust and contrarianism. This movement, termed science denialism, has been lurking and undermining public health efforts for decades. Specifically, it is “the employment of rhetorical arguments to give the appearance of legitimate debate where there is none, an approach that has the ultimate goal of rejecting a proposition on which a scientific consensus exists.” Unlike skepticism, which is “doubt as to the truth of something” and works to progress both science and society, denialism is characterized by individuals’ …

Re-Regulating Dietary Supplements, Jessie L. Bekker, Alex Flores, Michael S. Sinha

All Faculty Scholarship

In 1994, Congress introduced the Dietary Supplement Health and Education Act (DSHEA) to create a regulatory framework for the dietary supplement industry. Since the passage of DSHEA nearly thirty years ago, U.S. adults have steadily increased their annual consumption of dietary supplements. The once $4 billion industry comprising approximately 4,000 products has swelled to a $40 billion trade with anywhere from 50,000 to 80,000 dietary supplements available over-the-counter.

Despite the increased market size of dietary supplements, the Food and Drug Administration’s (FDA) pre-market authority to regulate the introduction of dietary supplements into the stream of commerce has remained subdued. Under …

Brief Amici Curiae Legal Scholars Of Sex And Gender In Support Of Plaintiff-Appellant, Kyle Velte, Ezra Young, Jeremiah A. Ho, M. Dru Levasseur, Nancy C. Marcus, Dara E. Purvis, Eliot Tracz, Ann E. Tweedy

All Faculty Scholarship

This amicus brief was filed in Griffith v. El Paso County, Colorado, case no. 23-1135 (10th Circuit) in support of appellant Darlene Griffith. Amici curiae are legal scholars of sex and gender. They offer expertise in their personal capacities to assist the Court of Appeals for the Tenth Circuit in assessing whether the El Paso County Sheriff officials violated Ms. Griffith’s Fourteenth Amendment right to equal protection when they refused to house Ms. Griffith, a transgender woman, in the women's unit of the El Paso County Jail as a pretrial detainee.

Anti-Carceral Theory And Immigration: A View From Two Law School Clinics, Sabrina Balgamwalla, Lauren Bartlett

All Faculty Scholarship

This article explores clinical teaching philosophies related to anti-carceral theory and provides examples of how to support student learning in clinics serving immigrant clients. Anti-carceral theory in this context is used to refer to an approach that resists criminalization and incarceration within law, drawing on abolitionism, intersectional and anti-carceral feminism, and decolonization.

The anti-carceral lens provides framing and language to name the dynamics of social exclusion and discrimination inherent in immigration law. It also allows us to unpack immigration regulation as a series of choices made within the larger context of law enforcement and its systems of surveillance, policing, and …

Protecting A Real Or Imagined Past: Justice Samuel Alito And The First Amendment, Derigan Silver, Dan V. Kozlowski

All Faculty Scholarship

This article examines the First Amendment jurisprudence of Justice Samuel Alito. In this article, we argue that the principles behind his decision-making are not always necessarily traditional methods of constitutional analysis, and litigants should understand the frames and lenses Alito uses to make decisions when making their arguments to him. The article concludes with a discussion of Alito’s overall approach to the law and some thoughts on how he is attempting to reshape the First Amendment. We write that, above all, it is clear he is seeking to protect a real or imagined past that, in his mind, is under …

Safety And Tolerability Results Of Atogepant For The Preventive Treatment Of Episodic Migraine From A 40-Week, Open-Label Multicenter Extension Of The Phase 3 Advance Trial, Brad C Klein, Rosa Miceli, Lawrence Severt, Peter Mcallister, Laszlo Mechtler, Jennifer Mcvige, Merle Diamond, Michael J. Marmura, Hua Guo, Michelle Finnegan, Joel M Trugman

Department of Neurology Faculty Papers

Background: Atogepant is a United States Food and Drug Administration-approved oral calcitonin gene-related peptide receptor antagonist for the preventive treatment of episodic migraine. The study objective was to evaluate the long-term safety and tolerability of atogepant in participants who completed the phase 3 ADVANCE trial (NCT03777059).

Methods: This 40-week, open-label extension trial (NCT03939312) monitored safety in participants receiving oral atogepant 60 mg once daily, followed by a four-week safety follow-up period.

Results: Of the 685 participants taking at least one dose of atogepant, the treatment period was completed by 74.6% of participants with a mean (standard …

The Role Affiliation Membership Plays In An Ffa Chapter: A Qualitative View From Kentucky, Jacob Falwell, Kristie B. Guffey

Murray State Theses and Dissertations

Research exists to demonstrate the benefits of FFA membership and the three-circle model of agriculture education. FFA membership had shown minimal growth in the 20 years following the rebranding. The innovative approach of affiliation membership has ushered in a steady growth of FFA membership, but not all chapters are participating in affiliation. FFA membership is provided to every student who is enrolled in agriculture education classes with affiliation, and the dues collection process is eliminated. This study investigated the view of affiliation membership in Kentucky High School Agriculture Education programs by researching the enrollment, involvement, and educational outcomes of affiliated …

Sequencing Of Extended Reality Welder Training, Monica Donohue

Murray State Theses and Dissertations

Abstract

This study used a quasi-experimental design to evaluate the efficacy of integrating XR welding simulations into traditional training programs. The performance outcomes of participants were assessed by an independent American Welding Society (AWS) Certified Welding Instructor (CWI). Participants were evaluated using the NCCER Performance Accreditation Tasks evaluation. After 20 hours of training, the participants used a traditional welder to perform a vertical 3F weld on a steel weld coupon. Three treatment groups were used to evaluate the sequence of extended reality welding simulators in a traditional welding program. Results indicate that sequencing XR practice before live welding did not …

A Phenomenological Study Of K-12 Educators' Perceptions Of Social Emotional Learning For K-12 Students In Southern Illinois., Ruth Cahill

Murray State Theses and Dissertations

The objective of this Phenomenological study was to analyze K-12 educators’ lived experiences, opinions, and perceptions regarding the impact of social emotional learning implementation in a small school district in Southern Illinois. Results revealed four consistent codes: Educator competence – the participants revealed that they did not feel competent enough to correctly implement SEL due to lack of consistent, on-going SEL training; Efficacy – due to school closures, virtual instruction, and inconsistencies caused by the corona-virus pandemic, SEL implementation in the school district was discontinued until further notice; Perception – the participants expressed that when implemented correctly, they believe that …

Comparison Of Corticosterone Concentrations Between Serum And Fecal Samples As A Measure Of Stress In Male Broilers., Kayla Weinacht

Murray State Theses and Dissertations

Stress has long been a topic of interest in the poultry industry due to its potential negative effects on chicken health and production of both eggs and meat. With increased global growth in egg and broiler production, more attention has been paid to the stressors that affect chickens in modern poultry operations, particularly environmental temperature and stocking density. Improving quantitative measurement of stress is always needed in poultry welfare research. In most studies, blood serum is measured for corticosterone, one of the biomarker hormones associated with stress in chickens. Methods of collecting blood serum are by their nature disruptive to …

The Effect Of An Afterschool Makerspace Program On Academic Achievement Of Sixth-Eighth Grade Students, Teresa Lampe

Murray State Theses and Dissertations

This quasi-experimental study investigated the effect of participation in an afterschool makerspace program on middle school students' academic achievement, grades, and school attendance. An experimental group of 237 sixth-eighth grade students participated in an afterschool makerspace program during the 2019-2020, 2020-2021, and 2021-2022 school years. A control group was selected using stratified random sampling of students from the same schools, grades, and special education designation who did not participate. The data included science and math NWEA scores, science and math grades, program attendance, school attendance, and gender. The data were analyzed using an independent t test with a 95% confidence …

An Exploratory Study Of Ergonomics In College Students, Wesley Ryan Tinker

Murray State Theses and Dissertations

Abstract

This study aimed to examine the relationship between poor ergonomic conditions and student physiological discrepancies. This examination provided great insight into students’ daily experiences and concerns for their futures. The methodology used for this study was quantitative as two source data sets were collected and analyzed. The tool REBA was used to measure the specific body angles while students sat working. A survey yielded great results, giving the students an opportunity to subjectively choose options.

This exploratory study allowed the researcher to use quantitative data to answer this study’s research questions. The research questions asked from this study were …

Self-Diagnosis & Pathologizing Normality During The Information Age, Chelsey Eaton

Murray State Theses and Dissertations

Self-diagnosis has become a concern for medical and mental health diagnoses. More people are engaging in self-diagnosis based on information that was obtained from the internet, including websites, social media platforms, and online forums. There are several reasons one may choose to self-diagnose. Some common reasons outlined in research are the desire to fit in with others who share similar characteristics and having a label to explain one’s experiences. Past research has shown that people frequently search for mental health information online, but they may not understand or may misinterpret the information that is found. This study aimed to address …

The Relationship Between Student Performance In English Language Proficiency And Academic Content Assessments, Rosa Wolford

Murray State Theses and Dissertations

As the number of English Learner (EL) students continue to increase in the United States and accountability increases for their growth and achievement in both English language proficiency and state content assessments, it is essential that educational agencies examine the predictive relationships between the assessments to ensure appropriate supports for English Learners are provided. Subsequently, the purpose of this study was to determine if there is a predictive relationship between the WIDA ACCESS Literacy and Overall Composite scores and the TNReady English Language Arts and Mathematics assessments scores of sampled EL students in fourth through twelfth grades among the subgroups …

Higher Education Awareness Amongst Noncommissioned Officers In The United States Army, Amanda Houser

Murray State Theses and Dissertations

Insufficient research exists concerning why active-duty enlisted noncommissioned officers do not pursue education past a high school diploma. Although higher education is becoming a minimum qualification in the civilian world, only 17% of enlisted servicemembers have higher than a high school degree. The purpose of this study is to explore the lived experiences, beliefs, and awareness of Army education benefits and the disconnect between higher education enrollment and active-duty noncommissioned officers. Two-hundred and sixty-five enlisted active-duty noncommissioned officers participated in an online survey and fifty-two noncommissioned officers participated in a one-on-one interview. Using a qualitative, grounded theory research design, both …

Women Pursuing An Agricultural Systems Technology Degree, Tanya Milam

Murray State Theses and Dissertations

Abstract

This phenomenological research study examined the factors influencing women to pursue an Agricultural Systems Technology (AST) degree and their self-efficacy in that field of study. Two research questions guided this study and data was analyzed from interviewing women enrolled in an Agricultural Systems Technology (AST) program at a mid-western university. The resulting four categories of Agricultural Experiences, Aptitude, Support, and Motivation were broken down into themes. The results were also applied to the theoretical framework of self-efficacy associated with career choice theories. Limitations of scope and generalizability indicate that further investigation of this topic is highly recommended.

Keywords: …

Halo Meets Horn: Influence Of Dissonant Information In Impressions, Amber Sanders

Murray State Theses and Dissertations

Abstract

The halo effect is a cognitive bias in impression formation that happens when people assume that when a person has a positive trait, such as physical attractiveness, the rest of their characteristics are also positive, leading to an overall positive perception of that person (Thorndike, 1920; Radeke & Stahelski, 2020). Conversely, the horns effect links together a negative trait, such as unattractiveness, with other seemingly negative traits (e.g., selfishness), leading to an overall negative perception (Radeke & Stahelski, 2020). However, these impression formation heuristics can lead to inaccurate impressions and poor judgments (Baumeister & Vohs, 2007). The current study …

Peer Response And Assistance To Suicidal Thoughts And Behavior In University Students, Lindsey Katherine Hunter

Murray State Theses and Dissertations

Suicide represents the second leading cause of death in adolescents and young adults (CDC, 2022). Many interventions employed on college campus focus on peer support which has been previously related to reductions in suicidal thoughts and behaviors (STB, e.g., suicidal ideation, suicidal plan, suicide attempts), but students may not have the experience needed to increase confidence or knowledge in providing support (Hirsch & Barton, 2011; King et al., 2008). Further, previous research has identified factors including exposure to STB, direct engagement in STB, knowledge, and stigma regarding suicide which have had mixed impact on confidence and helping intentions in supporting …

An Analysis Of P-20 Education At San Ildefonso Pueblo In Northern New Mexico, United States, Martin Edward Strones

Murray State Theses and Dissertations

This research study provides an inquiry by conducting a qualitative analysis of the conditions and issues associated with students at the San Ildefonso Pueblo in Northern New Mexico. For decades the education of San Ildefonso and Native Americans who live in the State of New Mexico has been ignored. This has been just the way it was, that is, until Wilhelmina Yazzie, a Native American, saw her son struggling in an unsatisfactory school system and decided to take action. This case was originally filed in McKinley Country, New Mexico, in 2014, home to largely Native American students for the Navajo …

A Geospatial Analysis Of Crime Hotspots, Campus Safety Measures, And The Campus Community’S Perceived Safety At Murray State University, Rachel Stuckey

Murray State Theses and Dissertations

Murray State University (Murray State) is in far Western Kentucky. Murray State prides itself on being a safe campus for prospective students. In this study spatial analysis was used to analyze the relationship among crime hotspots, campus safety measures, and students’ perception of safety on campus the campus of Murray State. A survey was distributed to students to determine the areas of the campus where students feel safe and unsafe. Geographical Information Systems (GIS) were used to determine the location of crime hotspots over eight years (2014-2022) to measure the spatial relationship between logged crime hotspots and perceived safe and …

Silver Carp Hypophthalmichthys Molitrix Movements In The Lower Cumberland River And Lower Tennessee River, Miranda Belanger

Murray State Theses and Dissertations

The introduction of exotic fishes in freshwater environments has caused significant ecological and economic changes. Silver Carp Hypophthalmichthys molitrix are an invasive species in the United States but are native to large rivers in eastern Asia. This species is expanding its range throughout the Mississippi River basin, beginning with the Cumberland River and Tennessee River drainages. Although Silver Carp movement patterns have been studied in other portions of the Cumberland River and Tennessee River, the lowermost portion of both rivers below Lake Barkley Dam and Kentucky Lake Dam is a unique environment in which the movement of Silver Carp has …