Digital Commons Network^™

Students’ Knowledge And Attitudes Towards Plagiarism At The Faculty Of Engineering Kyambogo University, Bonniface Agungi, Bonny Ongora

Library Philosophy and Practice (e-journal)

Students’ Knowledge and attitudes towards plagiarism at the Faculty of Engineering, Kyambogo University. The findings of the study revealed that the forms of plagiarism are copying work from the internet, submitting similar coursework and copying during test and exams, because of desire to get good grade, fear of failing, disinterest in the assignment, procrastination or poor time management and laziness encourage students to plagiarize therefore putting plagiarism as a course unit, conducting seminars to orient people about plagiarism, putting in place plagiarism detection software, motivating lecturers to teach students about plagiarism and training students on how to avoid plagiarism will …

Securing Digital Collections: Cyber Security Best Practices For Academic Libraries In Developing Countries, Ayooluwa Aregbesola, Ekene Lawrence Nwaolise

Library Philosophy and Practice (e-journal)

In today's digital era, there have been an ever increase in academic libraries embracing digital collections to provide access to a wealth of information to their users. However, the demerit of this digitization brings about the need to ensure the security of these valuable digital collections, especially in developing countries where cyber threats are rampant. This paper aims to address the challenges faced by academic libraries in developing countries with regards to best cybersecurity practices for securing digital collections. The paper also highlights the long-term benefits of prioritizing cyber security in academic libraries. Besides protecting valuable digital collections, robust cyber …

Imagining The Prospects And Possibilities Of Metaverse In Library And Information Services, Saumya Gupta, Paramjeet K. Walia

Library Philosophy and Practice (e-journal)

The metaverse is a novice and innovative technology with a huge potential to revolutionise the digital world and provide a more immersive user experience. The study discusses the layers and technologies associated with the metaverse, potential applications of the metaverse in library and information services and its inherent challenges. Metaverse technology has recently gained attention, and literature was mainly found in blogs and websites, and few from research articles. After analysing those studies, the researchers have tried to visualise the future application of the metaverse in the libraries. The findings shows that libraries can leverage the metaverse technology to render …

The Role Of Cloud Computing In Modern Libraries, Brighid Gonzales

Library Philosophy and Practice (e-journal)

With cloud computing because increasingly popular, libraries are finding many ways that it can meet their technology needs better than traditional technology infrastructure. Some of the benefits libraries can get from cloud computing include less need for libraries to provide their own full technology infrastructure, as well as less need for skilled IT workers to install and administer this technology. However, libraries opting to use cloud computing solutions also need to consider potential drawbacks such as the loss of control, a lack of customization options, and privacy and security concerns. Companies offering cloud computing services may offer several different options …

Knowledge Acquisition For Academic Activities By The Lecturers Of Institutes Of Nigerian Meteorological Agency, Ibrahim Ismail Rafindadi, Dr Amina Ibrahim Inkani, Professor Munir Abdullahi Kamba, Dalhatu Usman Mairiga, Abdulqawiyyu Mustapha, Umar Ali Haruna

Library Philosophy and Practice (e-journal)

Higher institutions of learning relies on active engagement in academic activities of which inform the teaching, researchand learning mission of institutions and are essential to robust democratic societies. The specific objectives of the study were to clarify the concept and significance, explore the academic activities engaged, and determine the knowledge acquisition programs by the lecturers of two (2) institutes of Nigerian meteorological agency. Qualitative data using a case study research design, face to face interview was used in gathering the data from a total of 16 purposively sampled respondents which were analysed using narrative based analysis. The study revealed that …

Postgraduate Students’ Use Of Electronic Resources For Research Output In Federal University Libraries In The Southeast, Nigeria: Challenges And Strategies For Interventions., Loveth Ogoegbunam Ekwueme, Augustina Chinyere Chime

Library Philosophy and Practice (e-journal)

This study is an empirical study that examined the challenges facing postgraduate students’ use of Electronic Information Resources [EIRs] for research output in federal university libraries in the southeast, Nigeria. It employed a descriptive survey design. The population of the study was registered postgraduate students in five universities libraries in 2017/2018 academic year comprising of 1,522 users. Yaro Yamane formula was used in calculating the sample size for each stratum in order to have proportional representation. A sample size of 421 postgraduate students was selected and used for the study. Instrument for data collection was questionnaire constructed on a four-point …

Users Satisfaction With Services, Resources, And Facilities In Nigeria Maritime University Library Okerenkoko, Delta State, Aroghene Eghwubare Mr., Confidence Reghagwa Idjai Mr, Oghenetega Gracious Agbori Mr

Library Philosophy and Practice (e-journal)

Abstract

The aim of the study was to examine users’ satisfaction with services, resources, and facilities in Nigeria Maritime University Library Okerenkoko, Delta State. The study adopted a descriptive survey design because of its potency in examining respondents via data collection and analysis to arrive at a conclusion. The total enumeration sampling technique was adopted for the study because of the manageable size of the population. The instrument used for eliciting data from the respondents was a structured questionnaire with the aid of two research assistants. The researcher distributed 215 copies of the questionnaire to the respondents and only 206 …

Knowledge Sharing And Referral Practices By Traditional Birth Attendants In Low-Income Urban Areas Of Southwest Nigeria, Janet O. Adekannbi, Joy O. Oluwafemi

Library Philosophy and Practice (e-journal)

Traditional birth attendants (TBAs) are important for maternal health care especially in Africa’s low-income areas. Without doubt, the relevance of TBAs in developing countries such as Nigeria is not expected to reduce in the foreseeable future. The knowledge of traditional birth attendants will continue to be needed and considering the tacit nature of their knowledge, there is a need to preserve the knowledge in this profession and promote sharing of best practices to prevent maternal mortality issues. This study investigated the knowledge sharing (KS) and referral practices of TBAs in low-income urban areas of South-west Nigeria. Qualitative approach was adopted …

Towards An Open And Inclusive Digital Humanities: Policies And Initiatives For Open Data Promotion In India, Mumtaj Mumtaj

Library Philosophy and Practice (e-journal)

The paper discusses about background of open data, policies and initiatives in the field of digital humanities in India. The article highlights the significance of open data on mankind and its potential in advancing research, promoting transparency, and encouraging collaborations. The article analyzes the current state of open data policies and initiatives in world as well as in India .The paper accentuates the significance of open data in enabling greater collaboration and inclusivity in the Digital Humanities in India, and calls for increased efforts to promote open data policies and initiatives in the country .The article talked about the successful …

Where Do Community College Students Go For Their Reference Management Needs: Findings From A Survey Study, Ajatshatru Pathak, Sarah Johnson

Library Philosophy and Practice (e-journal)

This research article reports the findings of a survey that was conducted at two community colleges affiliated with a large public university system in the Northeast of the United States. A survey was to explore community college students’ citation management help- seeking habits. Findings suggest that respondents were more likely to utilize Purdue University’s Online Writing Lab (OWL) website for reference management help than other resources. The results also show the impact of various factors (i.e., institution, academic level, undergraduate class level, field of study, age, gender, race/ethnicity, and user type) on students’ citation help -seeking practices. Significant statistical associations …

Glaucoma And Microglia-Induced Neuroinflammation, Makoto Ishikawa, Yukitoshi Izumi, Kota Sato, Taimu Sato, Charles F Zorumski, Hiroshi Kunikata, Toru Nakazawa

2020-Current year OA Pubs

Glaucoma is a multifactorial neurodegenerative disease characterized by a progressive optic neuropathy resulting in visual field defects. Elevated intraocular pressure (IOP) is the greatest risk factor for the development of glaucoma, and IOP reduction therapy is the only treatment currently available. However, there are many cases in which retinal degeneration progresses despite sufficient control of IOP. Therefore, it is important to elucidate the pathophysiology of glaucoma that is resistant to current IOP lowering therapies. Experiments using animal glaucoma models show the relationships between microglial neuroinflammatory responses and damage of retinal ganglion cells (RGCs). Inhibition of neuroinflammatory pathways associated with microglial …

Case Report: Peptide Receptor Radioligand Therapy In Metastatic Pediatric Neuroendocrine Tumors, Khanyisile Hlongwa, Olumayowa Kolade, Abdulilah Alnabulsi, Rachelle Steyn, Anita Brink, Vikas Prasad, Stuart More

2020-Current year OA Pubs

Neuroendocrine tumors (NETs) are not commonly diagnosed in children. Metastatic NETs tend to have poor outcomes, and this is seen in adult and pediatric populations. The role of somatostatin receptor imaging using [

Impact Of Multi-Source Data Augmentation On Performance Of Convolutional Neural Networks For Abnormality Classification In Mammography, Inchan Hwang, Hari Trivedi, Beatrice Brown-Mulry, Linglin Zhang, Vineela Nalla, Aimilia Gastounioti, Judy Gichoya, Laleh Seyyed-Kalantari, Imon Banerjee, Minjae Woo

2020-Current year OA Pubs

INTRODUCTION: To date, most mammography-related AI models have been trained using either film or digital mammogram datasets with little overlap. We investigated whether or not combining film and digital mammography during training will help or hinder modern models designed for use on digital mammograms.

METHODS: To this end, a total of six binary classifiers were trained for comparison. The first three classifiers were trained using images only from Emory Breast Imaging Dataset (EMBED) using ResNet50, ResNet101, and ResNet152 architectures. The next three classifiers were trained using images from EMBED, Curated Breast Imaging Subset of Digital Database for Screening Mammography (CBIS-DDSM), …

Inhibition Of Mirna Associated With A Disease-Specific Signature And Secreted Via Extracellular Vesicles Of Systemic Lupus Erythematosus Patients Suppresses Target Organ Inflammation In A Humanized Mouse Model, Nicholas A Young, Emily Schwarz, Braden M Zeno, Shane Bruckner, Rosana A Mesa, Kyle Jablonski, Lai-Chu Wu, Elisha D O Roberson, Wael N Jarjour

2020-Current year OA Pubs

INTRODUCTION: Distinct, disease-associated intracellular miRNA (miR) expression profiles have been observed in peripheral blood mononuclear cells (PBMCs) of systemic lupus erythematous (SLE) patients. Additionally, we have identified novel estrogenic responses in PBMCs from SLE patients and demonstrated that estrogen upregulates toll-like receptor (TLR)7 and TLR8 expression. TLR7 and TLR8 bind viral-derived single-stranded RNA to stimulate innate inflammatory responses, but recent studies have shown that miR-21, mir-29a, and miR-29b can also bind and activate these receptors when packaged and secreted in extracellular vesicles (EVs). The objective of this study was to evaluate the association of EV-encapsulated small RNA species in SLE …

Lymphatic Contractile Dysfunction In Mouse Models Of Cantú Syndrome With Katp Channel Gain-Of-Function, Michael J Davis, Jorge A Castorena-Gonzalez, Hae Jin Kim, Min Li, Maria Remedi, Colin G Nichols

2020-Current year OA Pubs

Cantú Syndrome (CS) is an autosomal dominant disorder caused by gain-of-function (GoF) mutations in the Kir6.1 and SUR2 subunits of K

Plasma And Cerebrospinal Fluid Proteomic Signatures Of Acutely Sleep-Deprived Humans: An Exploratory Study, Ana Vaquer-Alicea, Jinsheng Yu, Haiyan Liu, Brendan P Lucey

2020-Current year OA Pubs

STUDY OBJECTIVES: Acute sleep deprivation affects both central and peripheral biological processes. Prior research has mainly focused on specific proteins or biological pathways that are dysregulated in the setting of sustained wakefulness. This exploratory study aimed to provide a comprehensive view of the biological processes and proteins impacted by acute sleep deprivation in both plasma and cerebrospinal fluid (CSF).

METHODS: We collected plasma and CSF from human participants during one night of sleep deprivation and controlled normal sleep conditions. One thousand and three hundred proteins were measured at hour 0 and hour 24 using a high-scale aptamer-based proteomics platform (SOMAscan) …

Development Of An In-Vitro High-Throughput Screening System To Identify Modulators Of Genitalia Development, Yan Yin, Meade Haller, Tian Li, Liang Ma

2020-Current year OA Pubs

Sexually dimorphic outgrowth and differentiation of the embryonic genital tubercles (GTs) give rise to the penis in males and the clitoris in females. Defects in androgen production or in response to androgen signaling can lead to various congenital penile anomalies in both mice and humans. Due to lack of a high-throughput screening system, identification of crucial regulators of GT sexual differentiation has been slow. To overcome this research barrier, we isolated embryonic GT mesenchymal (GTme) cells to model genitalia growth and differentiation in vitro. Using either a mechanical or fluorescence-activated cell sorting-assisted purification method, GTme cells were isolated and assayed …

Editorial, Faizan Ali

Journal of Global Hospitality and Tourism

I am pleased to present the third issue of Journal of Global Hospitality and Tourism (JGHT), Volume 2, Issue 1. This issue focuses on ensuring the journal’s scope and strengthening its position in both conceptual developments and practical applications in global hospitality and tourism through publication of five quality manuscripts and 2 academic viewpoints: five full papers that underwent rigorous double-blind reviewing, an academic viewpoint, and an industry viewpoint. The present issue of JGHT contains five full papers, written by fourteen authors located in four different countries and affiliated with eight different universities.

Patient Experiences With Thyroid Nodules: A Qualitative Interview Survey, Matthew R Naunheim, Manuela Von Sneidern, Molly N Huston, Okenwa C Okose, Amr H Abdelhamid Ahmed, Gregory W Randolph, Mark G Shrime

2020-Current year OA Pubs

OBJECTIVE: To qualitatively explore the broad set of preferences and attitudes patients have about thyroid nodules, which influence the decision-making process.

STUDY DESIGN: A descriptive survey design was administered as interviews.

SETTING: Outpatient thyroid surgery clinic.

METHODS: Semistructured interviews were conducted with 20 patients presenting for initial evaluation of thyroid nodules at a surgeon's office. Probative, open-ended questions were posed regarding diagnosis, treatment, risk attitudes, and the decision-making process. Thematic analysis was used to develop code-transcribed interviews, and an iterative refinement resulted in underlying themes.

RESULTS: During the diagnostic process, patients integrated emotional responses (fear, anxiety, and shock) with rationale …

Intra-Articular Aav9 Α-L-Iduronidase Gene Replacement In The Canine Model Of Mucopolysaccharidosis Type I, Raymond Yu-Jeang Wang, Shih-Hsin Kan, Haoyue Zhang, Jodi D Smith, Afshin Aminian, Elizabeth Snella, Jackie K Jens, Sarah P Young, Patricia I Dickson, N Matthew Ellinwood

2020-Current year OA Pubs

Mucopolysaccharidosis type I (MPS I), an inherited lysosomal storage disorder characterized by deficiency of

Chronic Gcpii (Glutamate-Carboxypeptidase-Ii) Inhibition Reduces Pt217tau Levels In The Entorhinal And Dorsolateral Prefrontal Cortices Of Aged Macaques, Shveta Bathla, Nicolas Barthelemy, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Current approaches for treating sporadic Alzheimer's disease (sAD) focus on removal of amyloid beta 1-42 (Aβ

METHODS: Aged rhesus macaques were treated daily with the GCPII inhibitor, 2-MPPA (2-3-mercaptopropyl-penanedioic acid (2-MPPA)),Aged rhesus macaques were treated daily with the GCPII inhibitor, 2-MPPA (2-3-mercaptopropyl-penanedioic acid (2-MPPA)).

RESULTS: Aged macaques that received 2-MPPA had significantly lower pT217Tau levels in dlPFC and ERC, and had lowered plasma pT217Tau levels from baseline. pT217Tau levels correlated significantly with GCPII activity in dlPFC. Both 2-MPPA- and vehicle-treated monkeys showed cognitive improvement; 2-MPPA had no apparent side effects. Exploratory CSF analyses indicated reduced pS202Tau with 2-MPPA administration, …

Case Report: Insulin Hypersensitivity In Youth With Type 1 Diabetes, Einas H Alkhatib, Jody B Grundman, Anna M Adamusiak, Melena D Bellin, Joel P Brooks, Kevin S Buckley, Erin M Janssen, Maleewan Kitcharoensakkul, Kyle P Mcnerney, Thea L Pfeifer, Brooke I Polk, Brynn E Marks

2020-Current year OA Pubs

OBJECTIVE: Immediate type I, type III, and delayed type IV hypersensitivity reactions to insulin are rare, but potentially serious complications of exogenous insulin administration required for the treatment of type 1 diabetes (T1D).

METHODS: We present four cases of insulin hypersensitivity reactions occurring in youth with T1D and a literature review of this topic.

RESULTS: Insulin hypersensitivity reactions included types I, III, and IV with presentations ranging from localized urticaria, erythematous nodules, and eczematous plaques to anaphylaxis with respiratory distress. Reactions occurred in youth with newly diagnosed T1D and in those with long-standing T1D who were using both injection and …

Factors Influencing Delayed Clearance Of High Dose Methotrexate (Hdmtx) In Pediatric, Adolescent, And Young Adult Oncology Patients, Ema Mosleh, Stacy Snyder, Ningying Wu, Daniel N Willis, Rema Malone, Robert J Hayashi

2020-Current year OA Pubs

PURPOSE: To identify modifiable risk factors associated with prolonged clearance of methotrexate in pediatric, adolescent, and young adult (AYA) oncology patients receiving high dose methotrexate (HDMTX).

DESIGN/METHOD: A single institution, retrospective chart review of patients receiving HDMTX between 2010-2017. Patients had a diagnosis of either leukemia or osteosarcoma. Data included demographics, concurrent intravenous (IV) medications, IV fluids (IVF) administered, urine output (UO), and rises in serum creatinine (RSC) reflective of renal toxicity (RT). Outcome measures included 1) delayed targeted MTX clearance (DC), 2) actual time to clearance (TTC) and 3) length of stay (LOS).

RESULTS: Data from 447 HDMTX administrations …

Gene-Educational Attainment Interactions In A Multi-Population Genome-Wide Meta-Analysis Identify Novel Lipid Loci, Lisa De Las Fuentes, Karen L. Schwander, Yun Ju Sung, Mary F. Feitosa, Ahn Do, C. Charles Gu, Treva K. Rice, Mary K. Wojczynski, Michael M. Province, Dabeeru C. Rao, Et Al.

2020-Current year OA Pubs

No abstract provided.

What Can State Medical Boards Do To Effectively Address Serious Ethical Violations?, Tristan Mcintosh, Elizabeth Pendo, Heidi A Walsh, Kari A Baldwin, Patricia King, Emily E Anderson, Catherine V Caldicott, Jeffrey D Carter, Sandra H Johnson, Katherine Mathews, William A Norcross, Dana C Shaffer, James M Dubois

2020-Current year OA Pubs

State Medical Boards (SMBs) can take severe disciplinary actions (e.g., license revocation or suspension) against physicians who commit egregious wrongdoing in order to protect the public. However, there is noteworthy variability in the extent to which SMBs impose severe disciplinary action. In this manuscript, we present and synthesize a subset of 11 recommendations based on findings from our team's larger consensus-building project that identified a list of 56 policies and legal provisions SMBs can use to better protect patients from egregious wrongdoing by physicians.

Approach To Vaccinating The Pediatric Solid Organ Transplant Candidate And Recipient, Carol M Kao, Marian G Michaels

2020-Current year OA Pubs

Solid organ transplantation (SOT) candidates and recipients are at increased risk for morbidity and mortality from vaccine-preventable infections. Children are at particular risk given that they may not have completed their primary immunization series at time of transplant or have acquired natural immunity to pathogens from community exposures. Multiple society guidelines exist for vaccination of SOT candidate and recipients, although challenges remain given limited safety and efficacy data available for pediatric SOT recipients, particularly for live-vaccines. After transplant, individual patient nuances regarding exposure risks and net state of immunosuppression will impact timing of immunizations. The purpose of this review is …

Rare Predicted Loss-Of-Function Variants Of Type I Ifn Immunity Genes Are Associated With Life-Threatening Covid-19, Daniela Matuozzo, Megan A. Cooper, Et Al.

2020-Current year OA Pubs

No abstract provided.

Healthcare-Associated Infections (Hais) During The Coronavirus Disease 2019 (Covid-19) Pandemic: A Time-Series Analysis, John M Sahrmann, Katelin B Nickel, Dustin Stwalley, Erik R Dubberke, Patrick G Lyons, Andrew P Michelson, Kathleen M Mcmullen, Sumanth Gandra, Margaret A Olsen, Jennie H Kwon, Jason P Burnham

2020-Current year OA Pubs

OBJECTIVE: To use interrupted time-series analyses to investigate the impact of the coronavirus disease 2019 (COVID-19) pandemic on healthcare-associated infections (HAIs). We hypothesized that the pandemic would be associated with higher rates of HAIs after adjustment for confounders.

DESIGN: We conducted a cross-sectional study of HAIs in 3 hospitals in Missouri from January 1, 2017, through August 31, 2020, using interrupted time-series analysis with 2 counterfactual scenarios.

SETTING: The study was conducted at 1 large quaternary-care referral hospital and 2 community hospitals.

PARTICIPANTS: All adults ≥18 years of age hospitalized at a study hospital for ≥48 hours were included in …

A Single-Molecule Method For Measuring Fluorophore Labeling Yields For The Study Of Membrane Protein Oligomerization In Membranes, Melanie Ernst, Tugba N. Ozturk, Janice L. Robertson

2020-Current year OA Pubs

Membrane proteins are often observed as higher-order oligomers, and in some cases in multiple stoichiometric forms, raising the question of whether dynamic oligomerization can be linked to modulation of function. To better understand this potential regulatory mechanism, there is an ongoing effort to quantify equilibrium reactions of membrane protein oligomerization directly in membranes. Single-molecule photobleaching analysis is particularly useful for this as it provides a binary readout of fluorophores attached to protein subunits at dilute conditions. However, any quantification of stoichiometry also critically requires knowing the probability that a subunit is fluorescently labeled. Since labeling uncertainty is often unavoidable, we …

Sik3 And Wnk Converge On Fray To Regulate Glial K+ Buffering And Seizure Susceptibility, Lorenzo Lones, Aaron Diantonio

2020-Current year OA Pubs

Glial cells play a critical role in maintaining homeostatic ion concentration gradients. Salt-inducible kinase 3 (SIK3) regulates a gene expression program that controls K+ buffering in glia, and upregulation of this pathway suppresses seizure behavior in the eag, Shaker hyperexcitability mutant. Here we show that boosting the glial SIK3 K+ buffering pathway suppresses seizures in three additional molecularly diverse hyperexcitable mutants, highlighting the therapeutic potential of upregulating glial K+ buffering. We then explore additional mechanisms regulating glial K+ buffering. Fray, a transcriptional target of the SIK3 K+ buffering program, is a kinase that promotes K+ uptake by activating the Na+/K+/Cl- …