Digital Commons Network^™

Crowdsourcing/Winter Operations Dashboard Upgrade, Justin A. Mahlberg, Jairaj Desai, Haydn Malackowski, Howell Li, Jijo K. Mathew, Rahul Suryakant Sakhare, Timothy Wells, Darcy M. Bullock

JTRP Technical Reports

INDOT has recently completed the deployment of Parsons telematics-based dash-cameras, automatic vehicle locator (AVL) positions, and spreader rate monitoring across their winter operations fleet. The motivation of this study was to develop dashboards that integrate connected vehicle data into the real-time monitoring and after-action review of winter storms. Each month approximately 13 billion connected vehicle records are ingested for the state of Indiana and almost 99 billion weather data records are ingested nationwide in 15-minute intervals. This study developed techniques to utilize this connected vehicle data and weather data to monitor real-time mobility of interstates and post storm after-action assessments …

Indot Research Program Benefit Cost Analysis—Return On Investment For Projects Completed In Fy 2022, Bob Mccullouch

JTRP Technical Reports

To demonstrate the value of research and its implementation, the Governor’s Office initially requested an annual financial analysis of the INDOT Research Program to determine the return on the research investment (ROI). The INDOT Research & Development (R&D) has continued to publish an annual Return on Investment report. The current financial analysis is for research projects that completed in FY 2022. Analyses on previous year’s projects is necessary primarily due to the time it takes some project outcomes to be implemented and verifiable data generated, extending into the following year. Therefore, the FY 2023 analysis is completed research projects in …

Effectiveness Of Contrast Markings On Roadways And Orange Markings In Work Zones, Michael Williamson, Ping Lin

JTRP Technical Reports

Lane departure crashes are a leading cause of fatalities and injury crashes on roadways. To solve this problem, innovative marking in the form of contrasted white on concrete sections and orange marking in work zones were evaluated for their safety benefits. A highway safety manual approach was taken to evaluate the crash reduction benefits from each marking design. Orange marking in work zones were also evaluated for their speed, lane keeping, and lane choice effects. A survey of drivers was conducted on orange markings to ascertain public opinion, the survey indicated the potential for wide public acceptance of the new …

Investigating Consistency Among Bridge Inspectors Using Simulated Virtual Reality Testbed, Mohammad Jahanshahi, Shirley J. Dyke, Luis David Fernandez Vasquez, Nikkhil Vijaya Sankar, Yu-Ting Huang

JTRP Technical Reports

The current condition of US infrastructure requires a data-driven, risk-based approach to asset management. In the case of bridges, inspectors in every state visit these structures and collect data, and based on the information they report, state departments evaluate bridge conditions, predict deterioration, and make repair and retrofit decisions. However, the capacity of inspectors for defect detection might vary due to several factors, such as the inspectors’ experience or eyesight, which results in differences when reporting their results. Through the development of a virtual reality (VR)-based testbed, the variability among inspectors in examination and documentation practices in steel and concrete …

Development Of Protocols For Reuse Assessment Of Existing Foundations In Bridge Rehabilitation And Replacement Projects, Jeehee Lim, Rodrigo Salgado, Monica Prezzi, Yao Wang, Fei Han

JTRP Technical Reports

The existing foundations of a bridge can sometimes be reused. This may occur when a completely new bridge is built but also in bridge or superstructure widening projects. Reuse of existing foundations not only eliminates the costs associated with demolishing and disposing of old foundations, but also reduces the costs of the design and construction of new foundation elements. However, several challenges exist, including assessing the structural integrity, estimating the current capacity, estimating the remaining service life, and considering current design codes and specifications of the existing foundations, and clear guidelines for foundation reuse. The absence of foundation reuse guidelines …

Economic Effect Of Active Transportation Features And The Association Between The Healthcare Industry And Transportation, Steven R. Dunlop, Satish Ukkusuri, Dutt J. Thakkar, Shagun Mittal, Utkarsh Patil, Jainam Gala, Thomas Brady

JTRP Technical Reports

The goal of this project is to help INDOT determine the economic effects of active transportation features, the impact of transportation infrastructure on the healthcare industry, and to explore a potential relationship between active transportation and healthcare. To capture the details thoroughly, the analysis was done at a macro and micro level. We identified relevant attributes based on existing studies and captured the county-level data for these attributes from public sources. A regression analysis was performed at the macro-level to understand relationships and trends. In the micro-view, the analysis aimed to investigate the impact of active transportation investments on business …

Forecasting Shifts In Hoosiers’ Travel Demand And Behavior, Rajat Verma, Hao Luo, Saloni Deodhar, Eunhan Ka, Ricardo Chahine, Pallavi Natu, Harshit Malhotra, Vineeth Polisetty, Dutt J. Thakkar, Satish V. Ukkusuri, Hua Cai, Steven R. Dunlop, Anath V. Iyer, Konstantina Gkritza

JTRP Technical Reports

The changing landscape of transportation technology and traveler behavior, accelerated by recent events like COVID-19, has led to significant shifts in travel demand and vehicle miles traveled in Indiana. This study seeks to understand the long-term implications of these changes and their potential impact on passenger, freight, and micro-mobility movements across the state. To achieve this objective, this project focused on forecasting future transportation demand conditions and carrying out long-range scenario planning by accomplishing four tasks: forecasting travel demand shifts based on location-based data, evaluating medium-term inter- and intra-urban transportation demand shifts, forecasting county-level industry shifts using scenario-based growth models, …

Data Interpretation Of Automated Plate Load Test (Aplt) For Real-Time In Situ Determination Of Unbound Layer Resilient Modulus, Bianka Pajo, Peter J. Becker, Philippe L. Bourdeau, Marika Santagata

JTRP Technical Reports

This project examined the results of an extensive program of (1) cyclic plate loading tests carried out at Purdue University’s S-BRITE site on two testing strips comprised of a coarse aggregate (Indiana #53) subbase layer compacted over either untreated or cement-stabilized subgrade, and (2) static loading tests conducted on #53 aggregate compacted in a 3.6-foot-deep testing pit. The testing program on the two strips included multistage resilient modulus (MR) tests and extended cyclic performance tests with random distributed loading (RDL) tests on both the subbase and the underlying subgrade. Two of the RDL tests were performed at locations where a …

A Multicenter Study To Evaluate Pain Characteristics In Osteogenesis Imperfecta, Mercedes Rodriguez Celin, Karen M Kruger, Angela Caudill, Chaya N Murali, Sandesh C S Nagamani, Peter A Smith, Gerald F Harris

Faculty, Staff and Students Publications

The objective was to describe pain characteristics and treatments used in individuals with varying severity of osteogenesis imperfecta (OI) and investigate pain-associated variables. This work was derived from a multicenter, longitudinal, observational, natural history study of OI conducted at 12 clinical sites of the NIH Rare Diseases Clinical Research Network's Brittle Bone Disorders Consortium. Children and adults with a clinical, biochemical, or molecular diagnosis of OI were enrolled in the study. We did a cross-sectional analysis of chronic pain prevalence, characteristics, and treatments used for pain relief and longitudinal analysis to find the predictors of chronic pain. We included 861 …

Risk Stratification For Hepatocellular Cancer Among Patients With Cirrhosis Using A Hepatic Fat Polygenic Risk Score, Aaron P Thrift, Fasiha Kanwal, Yanhong Liu, Saira Khaderi, Amit G Singal, Jorge A Marrero, Nicole Loo, Sumeet K Asrani, Michelle Luster, Abeer Al-Sarraj, Jing Ning, Spiridon Tsavachidis, Xiangjun Gu, Christopher I Amos, Hashem B El-Serag

Faculty, Staff and Students Publications

BACKGROUND: Polygenic risk scores (PRS) hold the promise to refine prognostication in hepatocellular cancer (HCC). The few available HCC PRS include germline risk variants identified among individuals of mostly European ancestry, but data are lacking on the transportability of these PRS in multiethnic U.S patients with cirrhosis from multiple etiologies.

METHODS: We used data from 1644 patients with cirrhosis enrolled in two prospective cohort studies in the U.S. Patients were followed until HCC diagnosis, death, liver transplantation, or last study visit through June 30, 2021. The high-risk variants in PNPLA3-MBOAT7-TM6SF2-GCKR were combined in a PRS and we evaluated its association …

Engineered Cd4 T Cells Expressing A Membrane Anchored Viral Inhibitor Restrict Hiv-1 Through Cis And Trans Mechanisms, Weiming Wang, Khanghy Truong, Chaobaihui Ye, Suman Sharma, Huan He, Lihong Liu, Michael Wen, Anisha Misra, Paul Zhou, Jason T Kimata

Faculty, Staff and Students Publications

HIV-1 infection of target cells can occur through either cell-free virions or cell-cell transmission in a virological synapse, with the latter mechanism of infection reported to be 100- to 1,000-fold more efficient. Neutralizing antibodies and entry inhibitors effectively block cell-free HIV-1, but with few exceptions, they display much less inhibitory activity against cell-mediated HIV-1 transmission. Previously, we showed that engineering HIV-1 target cells by genetically linking single-chain variable fragments (scFvs) of antibodies to glycosyl phosphatidylinositol (GPI) potently blocks infection by cell-free virions and cell-mediated infection by immature dendritic cell (iDC)-captured HIV-1. Expression of scFvs on CD4

Postsurgical Morbidity And Mortality Favorably Informs Deep Brain Stimulation For New Indications Including Schizophrenia And Schizoaffective Disorder, Judith M Gault, Patrick Hosokawa, Daniel Kramer, Elyn R Saks, Paul S Appelbaum, John A Thompson, Ann Olincy, Nicola Cascella, Akira Sawa, Wayne Goodman, Nidal Moukaddam, Sameer A Sheth, William S Anderson, Rachel A Davis

Faculty, Staff and Students Publications

BACKGROUND: Deep brain stimulation (DBS) shows promise for new indications like treatment-refractory schizophrenia in early clinical trials. In the first DBS clinical trial for treatment refractory schizophrenia, despite promising results in treating psychosis, one of the eight subjects experienced both a symptomatic hemorrhage and an infection requiring device removal. Now, ethical concerns about higher surgical risk in schizophrenia/schizoaffective disorder (SZ/SAD) are impacting clinical trial progress. However, insufficient cases preclude conclusions regarding DBS risk in SZ/SAD. Therefore, we directly compare adverse surgical outcomes for all surgical procedures between SZ/SAD and Parkinson's disease (PD) cases to infer relative surgical risk relevant to …

Future Directions In Psychiatric Neurosurgery: Proceedings Of The 2022 American Society For Stereotactic And Functional Neurosurgery Meeting On Surgical Neuromodulation For Psychiatric Disorders, Frederick L Hitti, Alik S Widge, Patricio Riva-Posse, Donald A Malone, Michael S Okun, Maryam M Shanechi, Kelly D Foote, Sarah H Lisanby, Elizabeth Ankudowich, Srinivas Chivukula, Edward F Chang, Aysegul Gunduz, Clement Hamani, Ashley Feinsinger, Cynthia S Kubu, Winston Chiong, Jennifer A Chandler, Rafael Carbunaru, Binith Cheeran, Robert S Raike, Rachel A Davis, Casey H Halpern, Nora Vanegas-Arroyave, Dejan Markovic, Sarah K Bick, Cameron C Mcintyre, R Mark Richardson, Darin D Dougherty, Brian H Kopell, Jennifer A Sweet, Wayne K Goodman, Sameer A Sheth, Nader Pouratian

Faculty, Staff and Students Publications

OBJECTIVE: Despite advances in the treatment of psychiatric diseases, currently available therapies do not provide sufficient and durable relief for as many as 30-40% of patients. Neuromodulation, including deep brain stimulation (DBS), has emerged as a potential therapy for persistent disabling disease, however it has not yet gained widespread adoption. In 2016, the American Society for Stereotactic and Functional Neurosurgery (ASSFN) convened a meeting with leaders in the field to discuss a roadmap for the path forward. A follow-up meeting in 2022 aimed to review the current state of the field and to identify critical barriers and milestones for progress. …

Adeno-Associated Virus 8 Delivers An Immunomodulatory Peptide To Mouse Liver More Efficiently Than To Rat Liver, Yuqing Wang, Ayrea Hurley, Marco De Giorgi, Mark R Tanner, Rong-Chi Hu, Michael W Pennington, William R Lagor, Christine Beeton

Faculty, Staff and Students Publications

Targeting the Kv1.3 potassium channel has proven effective in reducing obesity and the severity of animal models of autoimmune disease. Stichodactyla toxin (ShK), isolated from the sea anemone Stichodactyla helianthus, is a potent blocker of Kv1.3. Several of its analogs are some of the most potent and selective blockers of this channel. However, like most biologics, ShK and its analogs require injections for their delivery, and repeated injections reduce patient compliance during the treatment of chronic diseases. We hypothesized that inducing the expression of an ShK analog by hepatocytes would remove the requirement for frequent injections and lead to a …

Combating Hypertension Beyond Genome-Wide Association Studies: Microbiome And Artificial Intelligence As Opportunities For Precision Medicine, Sachin Aryal, Ishan Manandhar, Xue Mei, Beng S Yeoh, Ramakumar Tummala, Piu Saha, Islam Osman, Jasenka Zubcevic, David J Durgan, Matam Vijay-Kumar, Bina Joe

Faculty, Staff and Students Publications

The single largest contributor to human mortality is cardiovascular disease, the top risk factor for which is hypertension (HTN). The last two decades have placed much emphasis on the identification of genetic factors contributing to HTN. As a result, over 1,500 genetic alleles have been associated with human HTN. Mapping studies using genetic models of HTN have yielded hundreds of blood pressure (BP) loci but their individual effects on BP are minor, which limits opportunities to target them in the clinic. The value of collecting genome-wide association data is evident in ongoing research, which is beginning to utilize these data …

Optical Coherence Tomography For Dynamic Investigation Of Mammalian Reproductive Processes, Kohei Umezu, Irina V Larina

Faculty, Staff and Students Publications

The biological events associated with mammalian reproductive processes are highly dynamic and tightly regulated by molecular, genetic, and biomechanical factors. Implementation of live imaging in reproductive research is vital for the advancement of our understanding of normal reproductive physiology and for improving the management of reproductive disorders. Optical coherence tomography (OCT) is emerging as a promising tool for dynamic volumetric imaging of various reproductive processes in mice and other animal models. In this review, we summarize recent studies employing OCT-based approaches toward the investigation of reproductive processes in both, males and females. We describe how OCT can be applied to …

Open-Source, Highly Efficient, Post-Acquisition Synchronization For 4d Dual-Contrast Imaging Of The Mouse Embryonic Heart Over Development With Optical Coherence Tomography, Andre C Faubert, Irina V Larina, Shang Wang

Faculty, Staff and Students Publications

Dynamic imaging of the beating embryonic heart in 3D is critical for understanding cardiac development and defects. Optical coherence tomography (OCT) plays an important role in embryonic heart imaging with its unique imaging scale and label-free contrasts. In particular, 4D (3D + time) OCT imaging enabled biomechanical analysis of the developing heart in various animal models. While ultrafast OCT systems allow for direct volumetric imaging of the beating heart, the imaging speed remains limited, leading to an image quality inferior to that produced by post-acquisition synchronization. As OCT systems become increasingly available to a wide range of biomedical researchers, a …

2023 Spring - Veterans Upward Bound Newsletter, Veterans Upward Bound, East Tennessee State University

Veterans Upward Bound Newsletters

No abstract provided.

Targeting Hiv-1 Reservoirs In T Cell Subsets, Min Li, Marietta M Budai, Min Chen, Jin Wang

Faculty, Staff and Students Publications

The HIV-1 reservoirs harbor the latent proviruses that are integrated into the host genome. It is a challenging task to eradicate the proviruses in order to achieve an HIV cure. We have described a strategy for the clearance of HIV-1 infection through selective elimination of host cells harboring replication-competent HIV (SECH), by inhibition of autophagy and promotion of apoptosis during viral re-activation. HIV-1 can infect various CD4+ T cell subsets, but it is not known whether the SECH approach is equally effective in targeting HIV-1 reservoirs in these different subsets in vivo. In a humanized mouse model, we found …

A Guide To Naming Eukaryotic Circular Rnas, Ling-Ling Chen, Albrecht Bindereif, Irene Bozzoni, Howard Y Chang, A Gregory Matera, Myriam Gorospe, Thomas B Hansen, Jørgen Kjems, Xu-Kai Ma, Jun Wei Pek, Nikolaus Rajewsky, Julia Salzman, Jeremy E Wilusz, Li Yang, Fangqing Zhao

Faculty, Staff and Students Publications

Alternative splicing of eukaryotic transcripts often leads to production of multiple mature RNAs from a single gene locus. In addition to encoding linear RNAs, genes can produce stable circular RNAs (circRNAs) that are often co-expressed with their cognate linear RNAs. Multiple distinct circRNAs are frequently generated from a gene locus via back-splicing, with each mature transcript having a potentially unique function due to its distinct combination of exons and sometimes retained introns. However, names currently given to circRNAs are often ambiguous and lack consistency across studies. Here, we call on the community to embrace standards for naming circRNAs so that …

Mortality Difference From Klebsiella Aerogenes Vs Enterobacter Cloacae Bloodstream Infections, Andrew Chou, Richard Sucgang, Richard J Hamill, Lynn Zechiedrich, Barbara W Trautner

Faculty, Staff and Students Publications

Members of the order Enterobacterales, including Escherichia coli , Klebsiella species and Enterobacter species, are important pathogens in healthcare-associated infections. Higher mortality has been reported from infections due to Klebsiella pneumoniae than from E. coli , but prior studies comparing Enterobacter aerogenes (recently renamed Klebsiella aerogenes ) bacteraemia and Enterobacter cloacae complex bacteraemia have yielded conflicting results regarding whether clinical outcomes differ. We found bacteraemia with K. aerogenes was independently associated with greater risk of 30-day mortality than bacteraemia with Enterobacter cloacae complex.

Breaking Free From "Crime-Free": State-Level Responses To Harmful Housing Ordinances, Jenna Prochaska

Lewis & Clark Law Review

Municipalities throughout the country enforce broad and harmful crime-free housing and nuisance property ordinances (CFNOs)—local laws that encourage landlords to evict or exclude tenants from housing opportunities based on their contact with the criminal legal system or calls for police help. There is little evidence that CFNOs are effective at achieving their stated goal of increasing community safety, and there is significant evidence that they harm Black and Latinx communities, survivors of domestic violence, individuals with disabilities, and low-income tenants and communities more broadly. Despite more than a decade of legal advocacy successfully challenging CFNOs using a range of legal …

Sounds Of Silence: A Thematic Analysis Of Victim Impact Statements, Tali Gal, Ruthy Lowenstein Lazar

Lewis & Clark Law Review

The Victim Impact Statement (VIS) is a legal document that crime victims submit to the court as part of the sentencing stage, informing the court about the harms they have suffered. The VIS enhances victims’ sense of procedural justice, voice, and inclusion in the process, as well as their overall wellbeing. At the same time, their use raises concern about defendants’ due process rights. The Article argues that VISs make a novel contribution to the criminal proceeding, beyond their formal goals of providing information to the court about the impact of the crime on its victims. Using a thematic analysis …

White Supremacy From The Bench, Vida B. Johnson

Lewis & Clark Law Review

Judges make important decisions in millions of cases a year across the country. Unlike other institutional players and unlike parties and their attorneys, judges are the only players in our adversarial legal system that are by design ostensibly neutral, impartial, and without bias.

Unfortunately, that legal fiction is not fact. Some judges do hold racial biases. A judge in Texas used racial slurs to describe Mexicans in his state in 2020. Also in 2020, a white judge in Louisiana referred to a deputy and a court clerk by the N-word, and the same year, a white Colorado judge also used …

Judicial Independence And The Rule Of Law, D. Brooks Smith

Lewis & Clark Law Review

No abstract provided.

Front Matter

Lewis & Clark Law Review

Front Matter includes Table of Contents, masthead, and faculty for Lewis & Clark Law Review Volume 27, Issue 2.

The New Orleans Transformation: Foster Care As A Rare, Time-Limited Intervention, Josh Gupta-Kagan, Christopher Church, Melissa Carter, Vivek Sankaran, Andrew Barclay

Lewis & Clark Law Review

This Article offers an initial evaluation of one reformed child protection system—New Orleans, Louisiana—and describes how a system that dramatically reduces the number of children in foster care might look. This system shows how a major metropolitan area can shrink its daily population of children in foster care to the low double digits, which would correspond to a reduction of the national daily foster care population by about 360,000. This reduction was mostly due to sending children home—usually to the homes from which they were removed—within days or weeks of removal, raising questions about the necessity of the original removal. …

Class Action Cy Pres: A Call For Reform Amidst Inconsistency And Criticism, Emily Potucek

Lewis & Clark Law Review

The prevalence of cy pres awards in class action settlements has increased remarkably in the last several decades. However as class action cy pres practice has become more commonplace, so have the concerns for its propriety in the class action context. Indeed because these concerns were recognized by the U.S. Supreme Court without further clarity on how, and whether, they can be alleviated, the viability of class action cy pres practice is uncertain. In response to this uncertainty, this Comment presents an exhaustive inquiry into cy pres practice in class action settlements. It demonstrates that while certain courts’ cy pres …

The Terms Of Their Deal: Revitalizing The Treaty Right To Limit State Jurisdiction In Indian Country, Dylan R. Hedden-Nicely

Lewis & Clark Law Review

For over 200 years, the “whole course of judicial decision” in the United States has recognized that American Indian tribes possess inherent sovereignty to govern their lands and people. Federal recognition of that sovereignty was memorialized in countless treaties, congressionally ratified agreements, and executive orders setting aside reservations throughout the United States. Throughout that same period, and with only minimal exception, the judiciary faithfully applied those treaties to protect tribal property rights, recognize tribal sovereignty, and bar states from imposing jurisdiction within Indian Country.

The jurisprudence in this arena has shifted, however, over the past few decades. Although the Supreme …

Juvenile Competency Restoration, David R. Katner

Lewis & Clark Law Review

Despite legal competence presumptions about juveniles facing delinquency charges, tens of thousands of forensic mental health evaluations challenge the status of court-involved children in the United States each year. Researchers now find mental health disorders prevalent among juveniles in the justice system, with up to 70% having a diagnosable mental health problem. It is inappropriate to think of adolescents as younger versions of adults whose behaviors can be viewed through the same lens as adult behaviors. The Article will explore some of the causes and conclusions about why many juveniles are not competent and why many of them may not …