Digital Commons Network^™

Enhanced Bmp Signaling In Cathepsin K-Positive Tendon Progenitors Induces Heterotopic Ossification, Hiroyuki Yamaguchi, Margaret Li, Megumi Kitami, Sowmya Swaminathan, Yuji Mishina, Yoshihiro Komatsu

Faculty, Staff and Student Publications

Heterotopic ossification (HO) is abnormal bone growth in soft tissues that results from injury, trauma, and rare genetic disorders. Bone morphogenetic proteins (BMPs) are critical osteogenic regulators which are involved in HO. However, it remains unclear how BMP signaling interacts with other extracellular stimuli to form HO. To address this question, using the Cre-loxP recombination system in mice, we conditionally expressed the constitutively activated BMP type I receptor ALK2 with a Q207D mutation (Ca-ALK2) in Cathepsin K-Cre labeled tendon progenitors (hereafter “Ca-Alk2:Ctsk-Cre”). Ca-Alk2:Ctsk-Cre mice were viable but they formed spontaneous HO in the Achilles tendon. Histological and molecular …

Effect Of Triple Antibiotic Paste, Double Antibiotic Paste, And Calcium Hydroxide On Antibiotic Resistance Of Tet Repressor Proteins, Tetracycline Resistance Gene W, And Tetracycline Resistance Gene Q: A Randomized Controlled Clinical Trial, Ertuğrul Karataş, Özgen Kırmızıbekmez, Mustafa Özkan Baltacı, Ahmet Adıgüzel

Journal of Dentistry Indonesia

Objective: To investigate the effect of the use of Calcium Hydroxide (Ca(OH)2), Triple Antibiotic Paste (TAP), and Double Antibiotic Paste (DAP) as intra-canal medicaments on the development of antibiotic resistance by evaluating tetracycline genes. Methods: Forty five patients were randomly assigned into 3 groups according to the intracanal medication using a web program (www.randomizer.org), (Ca(OH)2, TAP and DAP). Root canal bacteriological samples were collected before root canal treatment (S1) and after chemo-mechanical procedures (S2). Following root canal shaping procedures, intra-canal medication of the root canals was performed with selected intra-canal medicament. A second appointment was planned for the …

The Effect Of Several Electric Cigarette Puffs On Nanohybrid Composite Resin Surface Roughness, Alvi Rizqi Amaliyah, Haris Budi Widodo, Irfan Dwiandhono

Journal of Dentistry Indonesia

Nanohybrid composite resin is a dental restorative material comprising micro and nano-sized fillers. When accompanied by smoking habits, it can alter the surface roughness of composite resin. Objective: This study aimed to determine the effect of several electric cigarette (e-cigarette) puffs on the surface roughness of nanohybrid composite resin. Methods: This study was conducted in the experimental laboratory with a pretest-posttest control group design using 48 nanohybrid composite resin specimens divided into six groups. Subsequently, the experimental groups were exposed to 75, 150, 225, 300, and 450 puffs of e-cigarette, and the control group was given artificial saliva …

Evaluation Of Morphologic And Morphometric Characteristics Of The Mental Foramen And Anterior Loop In A Turkish Subpopulation Using Cone Beam Computed Tomography, Fatma Büşra Doğan, Faruk Akgünlü

Journal of Dentistry Indonesia

Objective: Before a surgical intervention in the mandibular interforaminal area, it is important to have a full understanding of the anatomy of the mandibular anterior segment. The evaluation of anatomical structures, variations and pathologies is performed with radiological imaging methods. Today, cone beam computed tomography (CBCT) is an imaging method which offers all the features necessary for this. In addition to its importance in surgical applications, it is also valuable in terms of anatomical studies thanks to the reliability of its measurements and the fact that it allows for a three-dimensional evaluation. The mental foramen and anterior loop are …

Prevalence And Clinical Characteristics Of Temporomandibular Disorders In Adults: An Epidemiological Study In The Mediterranean Region Of Türkiye, Esra Yavuz, Selmi Yardimci, Humeyra Tercanli

Journal of Dentistry Indonesia

The prevalence and clinical characteristics of temporomandibular disorders (TMD) in the Mediterranean region of Türkiye have not yet been thoroughly investigated. Objective: This study aimed to determine the prevalence and severity of TMD in a sample of the population in this region and to characterize the clinical findings related to TMD. Methods: Four hundred and one participants were included in this study. “Presence of TMD” in the participants was evaluated using the Fonseca Anamnestic Index. Through clinical examination, the findings in the participants were classified as limited mouth opening, deviation, temporomandibular joint (TMJ) sounds, TMJ pain, and muscle …

Case Report And X-Ray Microtomography And Scanning Electron Microscopy Analysis Of Teeth With Hypocalcified Amelogenesis Imperfecta, Rodrigo W. Marinoni, Thiago G. Silva, Leonardo S. Benato, Anelize M B Rumbelsperger, Antonio Adilson Soares De Lima

Journal of Dentistry Indonesia

Amelogenesis imperfecta (AI) is a genetic disease characterized by producing morphological and structural changes in tooth enamel. Objective: To highlight the morphological changes observed in teeth with hypocalcified AI based on scanning electron microscopy and microtomography analysis. Case report: An adult male had teeth seriously compromised by hypocalcified AI. The treatment plan involved removal of third molars followed by restorative and prosthetic treatment. After extraction, the teeth were analyzed by SEM and X-ray microtomography (microCT). Teeth with AI revealed the presence of microfractures arranged from the outer surface to the center of the enamel. Microfractures had a cracked or “cracked …

Factors Affecting The Preference Of Orthodontic Appliances Among Undergraduate Students In West Jakarta, Joko Kusnoto, Lia H. Andayani, Budi Kusnoto

Journal of Dentistry Indonesia

Malocclusion’s negative impact is not only limited to dentofacial appearance but also related to quality of life. Nowadays, orthodontic treatment can be done using conventional fixed appliances, or removable appliances called clear aligners. The preference for orthodontic appliances can be affected by several factors, including patient characteristics, self-perception, psychosocial, and oral-disorder factors. Objective: This study aims to evaluate the factors affecting the preference for orthodontic appliances among undergraduate students in West Jakarta. Methods: In this cross-sectional study, 244 undergraduate students were retrieved by purposive sampling from 7 universities located in West Jakarta. A self-administered questionnaire was used to …

Integration Of Massive Open Online Course (Mooc) In Conventional Teaching And Learning For Fixed Prosthodontics - A Case Study, Nor Faharina Abdul Hamid, Rohana Ahmad, Tong Wah Lim, Nur Hafizah Kamar Affendi, Tengku Fazrina Tengku Mohd Ariff, Melati Mahmud, Siti Mariam Ab Ghani

Journal of Dentistry Indonesia

The potential for Massive Open Online Courses (MOOCs) in clinical dentistry remains vague and inadequately explored. Objectives: The study aims to obtain insight into the development of MOOCs in Fixed Partial Dental Prostheses (FPDPs) and to assess students’ learning preferences, module quality, and interface usability. Methods: The MOOCs was created by seven academicians with prosthodontic backgrounds. After completing the MOOCs and three complementary online discussion sessions, the students (n = 89) were invited to participate in an online survey. SPSS version 23 was used to calculate the frequency, percentage, mean, and standard deviation of categorical data (SD). Results …

Vascular Injury Risk Stratification For Lateral Lumbar Interbody Fusion (Llif) At L4-L5: A Morphometric Study Using Magnetic Resonance Imaging, Takashi Hirase, Aaron J Greenberg, Catherine G Ambrose, Derek T Bernstein, Jeffrey J Ratusznik, Rex A W Marco

Faculty, Staff and Student Publications

BACKGROUND: Proper vascular injury risk stratification (VIRS) methods for L4-L5 lateral lumbar interbody fusion (LLIF) surgery have not been well-described. The objective of this study was to propose a novel VIRS method for L4-L5 LLIF surgery via the transpsoas approach.

METHODS: Axial magnetic resonance imaging (MRI) of adult patients were obtained and analyzed. The VIRS scores were assessed using anterior disc line to posterior vessel wall distance, the disc vessel angle (DVA), and the disc edge to vessel distance at the level of L4-L5 disc space.

RESULTS: Ninety-one consecutive adult patients were included in the study. The right common iliac …

Surface-Modified Pd/Ceo2 Single-Atom Catalyst Shows Increased Activity For Suzuki Cross-Coupling, Audrey Vice, Nicholas Langer, Benjamin J. Reinhart, Ofer Kedem

Chemistry Faculty Research and Publications

Single-atom catalysts (SACs) comprise catalytically active atoms dispersed on supports; they combine the high activity and site uniformity of homogeneous catalysts with the ease of separability of heterogeneous catalysts. However, SACs lack fine control over the active site, provided by ligands in homogeneous catalysts. In this work, we demonstrate that modification of the support with an organic monolayer is a viable approach to improving the catalytic performance. The addition of catechol-type monolayers to a Pd/CeO2 SAC increases its catalytic activity for Suzuki cross-coupling, a central reaction in the synthesis of fine chemicals and pharmaceuticals. Kinetic trials reveal that the coating …

Advancing The Care Of Individuals With Cancer Through Innovation & Technology: Proceedings From The Cardiology Oncology Innovation Summit 2020 And 2021, Peter Mcgranaghan

All Publications

As cancer therapies increase in effectiveness and patients' life expectancies improve, balancing oncologic efficacy while reducing acute and long-term cardiovascular toxicities has become of paramount importance. To address this pressing need, the Cardiology Oncology Innovation Network (COIN) was formed to bring together domain experts with the overarching goal of collaboratively investigating, applying, and educating widely on various forms of innovation to improve the quality of life and cardiovascular healthcare of patients undergoing and surviving cancer therapies. The COIN mission pillars of innovation, collaboration, and education have been implemented with cross-collaboration among academic institutions, private and public establishments, and industry and …

Citizens Apart? Representing Post-Brexit Youth Politics In The Uk Media, M Holton, J Lee, S Beech, S Mcdowell

School of Geography, Earth and Environmental Sciences

In 2016, the UK voted to leave the European Union (EU). This outcome was not only unexpected but also had clear geographical and age-bound divisions. While people over the age of 65 tended to vote to leave, younger voters were more likely to vote to remain a part of the EU. Reflecting on 7 years of journalism, this paper explores the ways in which young people have been represented by the news media with regards to the issue of Brexit. It analyses a database of 700 news media articles published from 2016 to 2022 across the UK, equating to 100 …

Late-Onset Stiff-Person Syndrome: Challenges In Diagnosis And Management, Marinos Dalakas, Jessica Yi

Department of Neurology Faculty Papers

BACKGROUND: Stiff person syndrome (SPS) is a rare slowly progressive autoimmune neuronal hyperexcitability disease with very-high GAD-65 antibody titers that most commonly presents above the age of 20, with muscle stiffness, painful muscle spasms, slow gait, and falls leading to disability. In other autoimmune disorders, late-onset disease has different symptom-spectrum and outcomes, but there is no information regarding late-onset SPS (LOSPS).

OBJECTIVE: Highlight delayed diagnosis and poor tolerance or incomplete response to therapies of patients with LOSPS and outline how best to increase disease awareness early at onset.

DESIGN A RETROSPECTIVE CHART REVIEWMETHODS: We reviewed GAD-positive SPS patients with symptom …

Cognitive Sequealae Of Covid-19 Is Not Predicted By Sars-Cov-2 Variants, Gabriel A. De Erausquin, Jorge Igor Zwir, Heather Snyder, Gabriela Gonzalez-Aleman, Hernan P. Zamponi, Mariana Figueredo-Aguiar, Emiliano Fumagalli, John Blangero, Agustín Yécora,, Fabiana Vaca, Gabriela Kukoc

School of Medicine Publications

Background: The long term sequelae of COVID-19 in older adults are only beginning to be clarified, and its predictors and underlying molecular mechanisms may shed light on the relationship between viral infections and Alzheimer's disease and related dementia.

Method: A prospective cohort of 874 older adult Amerindians from Argentina with COVID-19 illness confirmed by PCR of nasal swabs as well as controls, was established during the first year of the COVID-19 pandemic. We obtained data on the severity of the acute illness, as well as extensive neuropsychiatric and cognitive assessments, neurological exams (including quantitative hyposmia/anosmia), plasma for biomarkers and preliminary …

Cognitive Decline Associated With Longitudinal Changes In 24-H Ambulatory Blood Pressure Variability, Jesus D. Melgarejo, Kristina P. Vatcheva, Luis J. Mena, Carlos A. Chavez, Egle Silva, Gustavo E. Calmon, Rosa P. Mavarez, Joseph H. Lee, Joseph D. Terwilliger, Gladys E. Maestre

School of Medicine Publications

Background: Cognitive decline has been associated with variability in blood pressure (BP). However, whether the increment of the BP variability during follow-up precedes cognitive decline remains undocumented. We aimed this study to investigate cognitive decline in relation to longitudinal changes in 24-h reading-to-reading BP variability.

Methods: We conducted an observational longitudinal study that included 717 dementia-free participants from the Maracaibo Aging Study who underwent follow-up assessment in both 24-h ambulatory BP monitoring and cognitive tests between 1998 and 2015. Cognitive domains consisted of selective reminding tests (total, long-term, short-term, and recognition memory) and the Mini-Mental State Examination (MMSE). …

Four System Enablers Of Large-System Transformation In Health Care: A Mixed Methods Realist Evaluation, Emilie Francis-Auton, Janet C. Long, Mitchell Sarkies, Natalie Roberts, Johanna Westbrook, Jean Frederic Levesque, Diane E. Watson, Rebecca Hardwick, Peter Hibbert, Chiara Pomare, Jeffrey Braithwaite

Peninsula Medical School

Policy Points The implementation of large-scale health care interventions relies on a shared vision, commitment to change, coordination across sites, and a spanning of siloed knowledge. Enablers of the system should include building an authorizing environment; providing relevant, meaningful, transparent, and timely data; designating and distributing leadership and decision making; and fostering the emergence of a learning culture. Attention to these four enablers can set up a positive feedback loop to foster positive change that can protect against the loss of key staff, the presence of lone disruptors, and the enervating effects of uncertainty. Context: Large-scale transformative initiatives have the …

Improving Transparency In The Residency Application Process: Survey Study, Lindsey Ulin, Simone A Bernstein, Julio C Nunes, Alex Gu, Maya M Hammoud, Jessica A Gold, Kamran M Mirza

2020-Current year OA Pubs

BACKGROUND: Increasing numbers of residency applications create challenges for applicants and residency programs to assess if they are a good fit during the residency application and match process. Applicants face limited or conflicting information as they assess programs, leading to overapplying. A holistic review of residency applications is considered a gold standard for programs, but the current volumes and associated time constraints leave programs relying on numerical filters, which do not predict success in residency. Applicants could benefit from increased transparency in the residency application process.

OBJECTIVE: This study aims to determine the information applicants find most beneficial from residency …

Education For Primary Care Providers On Advance Care Planning: A Systematic Literature Review, Lindsey Ward

DNP Qualifying Manuscripts

Background: Healthcare providers in primary care treat patients at various stages of life. As patients age, it becomes necessary for providers to support their older patients throughout the aging process and address patient care even into life’s end stages. Primary care providers (PCPs) are well-positioned to provide this support and can do so through incorporating end-of-life (EOL) conversations in practice. Such discussions are called advance care planning (ACP). Though PCPs can play a crucial role in their patients’ EOL care decisions, providers report their limited knowledge of ACP as a barrier to its application.Consequently, further education for providers on utilizing …

Is Public Debt Environmentally Friendly? The Role Of Eu Fiscal Rules On Environmental Quality: An Empirical Assessment, Giovanni Carnazza, Thomas Renström, Luca Spataro

Fondazione Eni Enrico Mattei Working Papers

The EU has embarked on multiple initiatives reflecting its commitment to environmental enhancement and sustainable transitions. Notable among these are the European Green Deal and the NextGenerationEU recovery plan, both pivotal in fostering eco-friendly policies and sustainable practices within the region. Conversely, the fiscal rules within the EU, designed to manage budgetary deficits and debt-to-GDP ratios, may pose challenges to the implementation of fiscal measures targeted at achieving environmental quality objectives. These regulatory constraints potentially curtail the fiscal space available for policies aligned with the environmental goals set forth by the EU. To address this issue, using a panel of …

The Effects Of Poly(Ethylene Glycol) Grafting Density On The Extensional Solution Flows Of High Molecular Weight Polyacrylamide, Adam Linscott, Lauren Hong, Svetlana Morozova

Faculty Scholarship

Controlling the extensional rheological properties of solutions is of great interest for a number of applications, such as printing and coatings, as polymeric additives can modify a fluid's droplet size, formation, and breakup. We have measured the extensional flows of polyacrylamide graft poly(ethylene glycol) amine (PAM-g-PEGa) solutions as a function of grafting density. PAM-g-PEGa is synthesized with grafting densities of 2.5%, 5.5%, 8%, and 30% and extensional flow was analyzed with drop-on-substrate rheology. Flow time scales and profiles are then compared to understand the effects of backbone extension from the addition of side chains. At low grafting densities, the viscous …

Ypfs Lessons Learned Oral History Project: An Interview With Zoltan Pozsar, Zoltan Pozsar, Sandra Ward

Documents

No abstract provided.

Information Literacy Skills Among Female Students Of Secondary Schools In Bangladesh, Wares-Ul-Matin, Md. Jahangir Alam, Bilkis Begum, Md. Sakib Biswas

Library Philosophy and Practice (e-journal)

This study assessed information literacy skills among female students of secondary schools in Bangladesh. A structured questionnaire was developed consisting of library and ICT facilities, information literacy skills, ability to locate information, evaluate information sources, and use the approach of needed information. A total of 596 data were collected from female students of class nine of five general and five girls' high schools in the rural areas of Dhaka Districts. The study revealed that overall, 60.23% of the respondents were aware of IL; however, 49.33% of the female students were unable to locate academic information, 69.63% failed to identify information …

Point-Of-Care Ultrasound For The Diagnosis Of Frequent Cardiovascular Diseases: A Review, Ernesto Calderon Martinez, Edna Diarte, Diana Othon, Leonardo Rodriguez Reyes, Daniel A. Aguirre Cano, Carolina Cantu Navarro, Maria G. Ycaza, David Arriaga Escamilla, Jinal Choudhari, George Michel

School of Medicine Publications

Point-of-care ultrasound (POCUS) has emerged as an indispensable diagnostic tool in cardiology, particularly within the emergency department. This narrative synthesis provides a comprehensive exploration of POCUS applications in cardiovascular diseases, elucidating its multifaceted roles and addressing challenges. The review delves into the technical attributes of POCUS, emphasizing its noninvasive nature, radiation-free qualities, and suitability for non-radiologists. It navigates through educational strategies, stressing the importance of structured programs for the seamless integration of POCUS into clinical practice. Highlighting its efficacy, the synthesis discusses POCUS applications in various scenarios such as dyspnea, chest pain, cardiac arrest, aortic dissection, pericardial effusion, and pulmonary …

Impact Of Staff Engagement On The Safety And Quality Standards Of Health Services Organizations In Erbil: An Analytical Study, Satya Subrahmanyam, Sara Azad Fouad Arif

Arab Economic and Business Journal

The health-care sector leadership views staff engagement as a critical issue affecting the safety and quality standards provided by health service organisations. Various studies emphasize a strong association between staff engagement and the performance of the healthcare sector in the working environment. The aim of the research was to evaluate the relationship between staff engagement and the performance of the healthcare sector. By using the quantitative method, a total of 106 questionnaires were collected from the staff who work for private hospitals. The findings revealed that there is significant association between staff engagement and the performance of the healthcare sector.

Entrepreneurship Education Skills Acquisition For Self- Employment Among Librarians And Library Educators In Universities In South East Nigeria, Chidi Dike, Chioma Esther Osuji, Nkechi Amech, Genevieve Chinedu Umunna-Opara, Edward Amadi

Library Philosophy and Practice (e-journal)

The study investigated entrepreneurship education skills acquisition for self- employment among librarians and library educators in universities in South East, Nigeria. The study guided by five objectives, adopted descriptive survey design with a study population of 149 librarians and library educators from five (5) university-based Library and Information Science schools in South East, Nigeria. A survey census was used since the population is a manageable one, thus no sampling was conducted. Data for the study was collected using questionnaire titled, Entrepreneurship Education Skills Acquisition for Self-Employment among Librarians and Library Educators in Universities in South East Nigeria (EESALLE). 140 out …

Effects Of Screen Time On Children's Brain Development: A Scoping Review, Niloofar Jannesar, Todd E. Davenport, Lindsay Gietzen

Pacific Journal of Health

In this scoping review, the effects of screen time on cognitive, linguistic, and social-emotional development in children were studied by examining peer-reviewed articles published between 2018 and 2023. A total of 17 peer-reviewed articles were used in the study. The research reported that screen media provide a learning avenue, though it could be detrimental when children spend their time watching more than appropriate screen media. Furthermore, the study indicated that excessive screen media use may harm children’s executive function, which affects academic performance and language development. Related studies have also shown a correlation between excess screen use and problems like …

Smokejumper Obituary: Mcdonald, Joseph Franklin "Joe" (West Yellowstone 1951), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Tadayyun: Development Of Religiosity Scale In Islamic Perspective, Scientia Afifah Taibah, Lydia Freyani Hawadi, Thobib Al-Asyhar

Journal Of Middle East and Islamic Studies

This study aims to develop a religiosity scale called tadayyun, based on an Islamic approach rooted in the Qur'an, hadith, and the opinions of scholars. The research sample consisted of 269 participants residing throughout Indonesia, ranging in age from 18 to 40 years old. Data were collected using the tadayyun scale, which comprised 27 items derived from literature studies. The reliability test results, measured using Cronbach's Alpha, yielded a value of 0.839, indicating good internal consistency. All items demonstrated satisfactory discrimination abilities (p>0.138). Validation was conducted through Exploratory Factor Analysis, identifying three factors. Three items did not meet the …

The Impact Of Covid-19 Outbreaks On The Profits Of Islamic Banks In Indonesia, Sabri Rahman Siregar

Journal Of Middle East and Islamic Studies

Abstract

The Covid-19 outbreaks hit various business lines in Indonesia. The banking sector has yet to escape the impact of this outbreak. The emergence of the Coci-19 outbreaks in Indonesia can result in the emergence of risks to the performance of Islamic Commercial Banks. This study aims to analyze what factors influenced the level of profitability of Islamic Commercial Banks in the 2020-2022 period when the Covid-19 outbreaks took place in Indonesia. The method used in this research is quantitative by using panel data regression analysis. In this study, there are three categories of variables used. The first category is …

Combined Risk Based Inspection And Fault Tree Analysis For Repetitive 3-Phase Line Piping Leakage At West Java Offshore Topside Facility, Dona Yuliati, Akhmad Herman Yuwono, D. Rizal Asral, Donanta Dhaneswara

Journal of Materials Exploration and Findings

Hydrocarbon releases might result in serious consequences in various aspects. In addition to the contribution to environmental pollution, repetitive leakages need high repair costs. This study aim is to minimize potential repetitive leakage for other typical 3-phase piping systems. We conducted the risk assessment by adopting Risk Based Inspection (RBI) API 581 to identify risk level, calculating piping lifetime, recommended inspection plan and mitigations. The most relevant root causes can be obtained through quantitative Fault Tree Analysis (FTA). Observation and investigation was taken from eight 3-phase piping systems that experienced repetitive leakages. It has been found that the risk level …