Digital Commons Network^™

Lilrb3 Modulates Acute Myeloid Leukemia Progression And Acts As An Effective Target For Car T-Cell Therapy, Jilu Zhang, Yi-Ling Wang, Yongbin Liu, Fumiko Nakatsu, Xiaoxuan Wang, Jing Fang, Yitian Xu, Vitaliy Davidov, Kyeongah Kang, Sai Ravi Pingali, Siddhartha Ganguly, Masataka Suzuki, Marina Konopleva, Brooke Prinzing, Youli Zu, Stephen Gottschalk, Yong Lu, Shu-Hsia Chen, Ping-Ying Pan

Faculty, Staff and Students Publications

Identifying novel cell surface receptors that regulate leukemia cell differentiation and can be targeted to inhibit cellular proliferation is crucial to improve current treatment modalities in acute myeloid leukemia (AML), especially for relapsed or chemotherapy-refractory leukemia. Leukocyte immunoglobulin-like receptor type B (LILRB) is an immunomodulatory receptor originally found to be expressed in myeloid cells. In this study, we found that LILRB receptors can be induced under inflammatory stimuli and chemotherapy treatment conditions. Blockade of LILRB3 inhibited leukemia cell proliferation and leukemia progression. Additionally, treatment with LILRB3 blocking antibodies upregulated myeloid lineage differentiation transcription factors, including PU.1, C/EBP family, and IRF, …

Gatekeeping At Bio

Faculty, Staff and Students Publications

No abstract provided.

Acceptability And Use Of An Online Health Priorities Self-Identification Tool For Older Adults: A Qualitative Investigation, Aanand Naik

Faculty, Staff and Student Publications

OBJECTIVE: To examine the use of a web-based, self-directed health priorities identification tool for older adults with multiple chronic conditions (MCCs).

METHODS: We recruited a gender- and racially-diverse, highly educated sample of older adults with MCCs to engage with our My Health Priorities tool, then complete a semi-structured interview. Thematic analysis was used to examine interview transcripts.

RESULTS: Twenty-one participants shared perspectives on the acceptability and use of the tool. Three themes (with eleven subthemes) were generated to describe: website

CONCLUSION: Participants found this tool acceptable and easy to use, describing a variety of benefits of the priorities self-identification process …

From Margins To Museums: Tracing The Evolution Of Representation For Contemporary African Artists In The United States, Victoria Mouraux Durand-Ruel

Master's Theses

This thesis examines the impact of the Black Lives Matter movement on the art community in the United States and the evolution of representation for Contemporary African artists. By analyzing the careers and artistic contributions of Omar Ba, Toyin Ojih Odutola, and Njideka Akunyili Crosby, the study explores the concept of artistic agency according to which African artists have more control over the production and distribution of their works.

The research begins with a comprehensive literature review, investigating the historical contexts that have shaped the art landscape, including the impact of colonization, decolonization, and globalization. The study reveals how these …

Advances In Diagnostic Tools And Therapeutic Approaches For Gliomas: A Comprehensive Review, Gayathree Thenuwara Nanolab Research Centre, James Curtin, Furong Tian Nanolab Research Centre

Articles

Gliomas, a prevalent category of primary malignant brain tumors, pose formidable clinical challenges due to their invasive nature and limited treatment options. The current therapeutic landscape for gliomas is constrained by a “one-size-fits-all” paradigm, significantly restricting treatment efficacy. Despite the implementation of multimodal therapeutic strategies, survival rates remain disheartening. The conventional treatment approach, involving surgical resection, radiation, and chemotherapy, grapples with substantial limitations, particularly in addressing the invasive nature of gliomas. Conventional diagnostic tools, including computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET), play pivotal roles in outlining tumor characteristics. However, they face limitations, such as …

Ibn Khaldun's Economic Philosophy, Warqa Yunus Yahya

Alustath Journal for Human and Social Sciences

This research is entitled (Ibn Khaldun's economic philosophy) and Ibn Khaldun (d.: 808 AH) is Abu Zaid Wali al-Din Abd al-Rahman, famously known as Ibn Khaldun, he was born in Tunisia in 732 AH, and he is famous for his author (Book of Al AbAER) and the introduction to the book known as the Introduction. Learned from his father and some Tunisian scholars studied interpretation, hadith, jurisprudence, language and grammar, as well as mental sciences such as logic, philosophy, arithmetic and other sciences. Which is economic cooperation, and the factors affecting livelihood and poverty, but in terms of the vocabulary …

The Rhetorical Orientation Of The Phenomenon Of Contextual Syntactic Deviation In Surat Al-Baqarah, Bakil Ali Mahmoud Al-Marani

Alustath Journal for Human and Social Sciences

The phenomenon of contextual syntactic deviation has attracted a great deal of attention from linguists and rhetoricians. It is a linguistic phenomenon associated with the change of meaning that occurs when the established pattern in the grammatical rules is deviated from. In other words, it refers to a displacement or change in the linguistic structure or sentence structure. This deviation is justified by the context, and it is an intentional deviation that aims to give the literary text - of all its types - new meanings that are rhetorically directed to cause a psychological impact on the recipient. This phenomenon …

The Position Of Ancient And Contemporary Critics On Prose-Related Issues, Torj Zaini Wind

Alustath Journal for Human and Social Sciences

This study explores the opinions of ancient and contemporary critics on the issues related to Arabic prose. Given the importance of all forms of Arabic prose in the development of the Arab though and the development of Islamic civilization, this analytic-descriptive research aims to analyze the opinions of these critics about prose and also seeks to compare their critical opinions. The research concludes that ancient critics did not offer scientific or lengthy opinions about literary criticism since their primary focus was on poetry. On the contrary, contemporary critics believe that prose is the origin of science and thought and the …

The Influence Of The Arabic Language On The Persian Language In The Mirror Of The Prose ‘Al-Monsha’At By Farhad Mirza Mo’Tamid Al-Dawlah, Gholamreza Karimifard, Mahmoud Abdanan, Manouchehr Tashakkori, Ali Arameshpour

Alustath Journal for Human and Social Sciences

The interrelationship between Arabic and Persian has been an old one manifested mainly by the arrival of Islam into Iran and simultaneously the creation of the first Persian works of literature in the third and fourth centuries. It was, indeed, Arabic, which exerted more influence. The culmination of this influence can be seen in a literary style called Eraghi typical of seventh and eighth centuries. Many Persian poets and writers tried to emulate their ancestors in the use of Arabic since then .The influence, thus, lives on during other dynasties including Safavids and Qajariye; to various degrees, though. Farhad Mirza, …

A Critical Discourse Analysis Of Hate Speech Directed Towards Iraqi Tv Series’ Performers On Social Media, Mahmood Adil Almuslehi

Alustath Journal for Human and Social Sciences

This study investigates online hate speech directed against Iraqi actors and actresses in the online environment of Facebook and Instagram platforms. Fairclough’s (2001) Three-Dimensional Model is employed in this study to unravel the delicate fabric of language used in hate remarks, demonstrating its function in generating discriminatory discourse and falling under the broad purview of Critical Discourse Analysis (CDA). To provide nuanced insights into the mechanisms by which online hate speech operates and the wider socio-cultural implications it engenders, it also seeks to uncover the latent ideologies and belief systems that underlie hate comments and to illuminate their intersections with …

Artificial Intelligence And Teachers' Sustainability :Preschool Teachers' Perceptions Of Conditions And Level Of Support For Professional Development In Early Childhood Special Education, Rana Saleh Alghamdi, Amr Mahmoud, Tahany Sabry Shaaban

Alustath Journal for Human and Social Sciences

The purpose of this research is to explore Saudi early childhood special education (ECSE) teachers' attitudes towards professional development programs in ECSE. For this reason, survey data was obtained from 30 Saudi ECSE teachers who worked in Saudi Arabian early childhood stages, and then an interview was conducted with five of them to find out their training needs and the challenges they face. The researchers used the qualitative technique, which included a pre-survey and interviews. An online questionnaire was provided to the participants in order to examine their impressions of the professional development programs and assess their judgments of the …

A Comparative Analysis Of The Baghdad And Babylon Universities Exploring Factors Affecting Their Competitiveness In World University Rankings, Ahmed Kanaan Suleiman

Alustath Journal for Human and Social Sciences

In recent years, global university rankings have gained popularity as a means of evaluating the quality of higher education institutions because they provide valuable insights into the best institutions around the globe; therefore, employers, academics, and students use this ranking to decide from where to hire new employees, where to pursue higher education, and where to conduct research. This holds true for Iraqi universities as well, as they strive to assess their standing and competitiveness on a global scale. In this study, the findings of Baghdad and Babylon universities in the Times Ranking are analyzed and compared. Additionally, the factors, …

Unravelling The Potential Mortality Benefits Of Mass Drug Administration With Azithromycin In Niger, Zulfiqar Ahmed Bhutta

Centre of Excellence in Women and Child Health

No abstract provided.

Dark Moon Shallow Sea (The Gods Of Night And Day Series, Vol. 1) By David R. Slayton, Phillip Fitzsimmons

Faculty Articles & Research

Book review of Dark Moon Shallow Sea (The Gods of Night and Day Series, vol 1) by author David R. Slayton. Book review by Phillip Fitzsimmons.

United States Oil Discovery, Regulation And Economic Employment 1859 -1918, Ammar Hussein Ali

Alustath Journal for Human and Social Sciences

Abstract
The discovery of oil in the United States of America in 1859 contributed to its technical development and industrial and economic excellence, as its oil companies, especially the company that operated Standard Oil, developed the means of extracting, refining, and exporting it, which monopolized the industry until 1911, when the Supreme Court ordered the dismantling of the company to several companies, following which it emerged. Five major American companies dominated the world's oil industry until the early 1950s, contributing to the development of the U.S. economy by increasing financial revenues by exporting oil to all countries in the world. …

The Level Of Linguistic Intelligence Among Middle School Students And Its Relationship Motivation To Learn Arabic, Mahmoud Hilal Abdel Baset Abdel Qader

Alustath Journal for Human and Social Sciences

The current study aimed to reveal the level of linguistic intelligence of the third intermediate grade students and its relationship to motivation to learn the Arabic language. To achieve this goal, the study tools were prepared, which were: a measure of linguistic intelligence, a measure of motivation to learn the Arabic language, then ensuring the validity and reliability of the tools, then selecting a study sample of third grade students in the city of Abha, Saudi Arabia, then applying the research tools, then Statistical analysis, interpretation of results, and presentation of recommendations and proposals. The results showed: a low level …

The Effect Of Bilingualism On Cognitive Development In Children Review Article, Amal Mahmoud Ali

Alustath Journal for Human and Social Sciences

Bilingualism has become an increasingly common phenomenon in today’s globalized world, with many children growing up exposed to two or more languages. As a result, there has been growing interest among researchers in understanding the impact of bilingualism on thinking development in young and children. Some studies confirmed that bilingualism can have a positive effect on children’s perception cognitive development, particularly in the zones of attention control, Operational memory, and cognitive flexibility. Dual-language learners may also have better Planning and organization skills, such as task-switching and inhibitory control, compared to monolingual children. These cognitive advantages may be due to the …

Living Among Wildlife: Elevating Human-Wildlife Interactions And Coexistence, Bridget Rebecca Murphy

Graduate Student Portfolios, Professional Papers, and Capstone Projects

After a semester of learning, both in class and in nature, my writing honed in further on this human-nature divide. To me, I see humans as part of nature – as we are mammals, animals, part of the food chain, biological beings no higher than others on our planet. We have simply constructed this false narrative around us within our societies, minds and media that embeds this division between us and nature, between us and wildlife. Humans have been managing, stewarding, living off and within landscapes for thousands of years. As time and technology evolved, a lot of people began …

Data Journalism Portfolio, Mrinalini Nayak

Capstones

I'm a data-driven business and economics reporter based in Manhattan, New York, with 16 months of graduate school experience. Through this program, not only did I learn that data analysis is at the core of most investigative projects in today's world, but I developed the confidence to back my reporting with data. Suppose you, like me, have felt like your voice as a journalist could be encouraged by solid proof in the form of data, ranging from salaries for public servants to energy units required to run large language models. In that case, you only need to learn Python for …

A Silent New Threat To The Trans Community: The Unregulated Use Of Ai Without Public Consent Raises Ethical Concerns, Eduardo Salazar Uribe

Capstones

Abstract:

The unregulated use of artificial intelligence (AI) without public consent has raised ethical concerns, particularly affecting marginalized communities such as transgender individuals. This project, based on interviews with 34 transgender people, explores the impact of AI on historically marginalized minorities, emphasizing the urgent need for an ethical and legal framework. This research reveals instances of discrimination and challenges faced by transgender individuals at various stages, from border control to airport security, highlighting the limitations and biases of AI in recognizing diverse gender identities. Trans rights activists, and AI experts remark the importance of inclusivity in AI development and regulation. …

Erasing Race, Emily Swanson

Capstones

Since the murder of George Floyd, the Minneapolis Police Department has increasingly lagged in its reporting of race data.

Monitoring Time Domain Characteristics Of Parkinson's Disease Using 3d Memristive Neuromorphic System, Md Abu Bakr Siddique, Yan Zhang, Hongyu An

Michigan Tech Publications

INTRODUCTION: Parkinson's disease (PD) is a neurodegenerative disorder affecting millions of patients. Closed-Loop Deep Brain Stimulation (CL-DBS) is a therapy that can alleviate the symptoms of PD. The CL-DBS system consists of an electrode sending electrical stimulation signals to a specific region of the brain and a battery-powered stimulator implanted in the chest. The electrical stimuli in CL-DBS systems need to be adjusted in real-time in accordance with the state of PD symptoms. Therefore, fast and precise monitoring of PD symptoms is a critical function for CL-DBS systems. However, the current CL-DBS techniques suffer from high computational demands for real-time …

School Weigh-Ins Are Dreaded. They Also Don’T Work., Amanda G. Salazar

Capstones

Schools across the country have been screening their students for Body Mass Index for decades, based on the assumption that telling families about a student's weight would promote weight loss. Years of research has shown that BMI screenings don't actually have any impact on weight, but instead can be harmful to students' mental and emotional wellbeing. These harms can last for years into the future, in some cases. So, why are BMI screenings still such a common practice?https://schoolbmiscreenings.weebly.com/

Wave-Ing Away Stereotypes: The Rise Of Black Surfers, John J. Schilling Iii

Capstones

This article examines the growing prominence of Black surfers with a specific focus on Lou Harris of the Black Surfing Association East Coast Chapter in Rockaway Beach, New York. While the sport remains white male-dominated, a 2022 report from the Surf Industry Members Association and ActionWatch show that surfing has experienced a surge in diversity over the last decade with an increase in the number of Black surfers, female surfers and other surfers of color nationwide. In exploring this phenomenon, this article includes the historical background of Black people’s connection to the sport, dating back to enslaved Africans’ complicated interactions …

“Nadie Nunca Me Habló De Riesgos”: Madres Subrogantes En Eeuu Reclaman Protección, Carla Gloria Colomé Santiago

Capstones

Commercial surrogacy is a growing industry. In the United States, the Centers for Disease Control and Prevention (CDC) reported that by 2020, 90 percent of clinics in the country were offering gestational carrier services. In this report, several surrogate mothers speak of inefficient contracts, poor pay and lack of support, amid a landscape where business takes precedence over the treatment of women.

https://preview.shorthand.com/dN8XSDPrI83UIc8P

Understanding And Navigating Asylum In Nyc, Divya Murthy

Capstones

Between September 2022 and December 2023, I worked with the community of grassroots volunteers and organizations in New York helping alleviate the impact of the asylum-seeker crisis in the city. My work is a combination of reporting on the crisis through articles, video and audio as well as an application of engagement journalism techniques, like callouts, joining community groups and sustained conversations with community members.

Link: https://medium.com/@divyamurthy/understanding-and-navigating-asylum-in-nyc-646ab96d0ac1

The Effect Of Visual Arts On At-Risk Students, Nicole E. Seidler

Dissertations, Theses, and Projects

Creation through visual art is demonstrated by a variety of all ages. Visual art-based learning is known to build focus, reduce stress, provide a sense of accomplishment, and spark an increase in well-being. Many people have been known to benefit from the creation of art. With the COVID-19 pandemic back in 2020, educators across the country have noticed an increase of students who are considered at-risk. Many school districts have made it a priority to look at ways of improving these students’ behavior, participation, view on school, or overall well-being. This research study takes place at a rural Wisconsin high …

Gender Representation In Indian Television Advertisements From 2011 To 2020, Himika Akram

Electronic Theses & Dissertations

This thesis delves into the ways in which gender is portrayed in Indian television advertisements, with a focus on key areas such as male and female ratio as primary characters, in voiceovers, at home, outdoor, and workplace settings, and finally, in product categories. The thesis draws on a content analysis of 120 strategically selected Indian television advertisements from 120 brands from 2011 to 2020. Findings reveal that men were portrayed as the primary characters in 54.6% of these advertisements, and females were portrayed as the primary characters in 45.4% of advertisements. For voiceovers, the male ratio was 70.1%, and the …

Microplate-Like Metal Pyrophosphate Engineered On Ni-Foam Towards Multifunctional Electrode Material For Energy Conversion And Storage, Rishabh Srivastava

Electronic Theses & Dissertations

High clean energy demand, dire need for sustainable development, and low carbon footprints are the few intuitive challenges, leading researchers to aim for research and development for high-performance energy devices. The development of materials used in energy devices is currently focused on enhancing the performance, electronic properties, and durability of devices. Tunning the attributes of transition metals using pyrophosphate (P₂O₇) ligand moieties can be a promising approach to meet the requirements of energy devices such as water electrolyzers and supercapacitors, although such a material’s configuration is rarely exposed for this purpose of study.

Herein, we grow …

Road To Recovery For Craniotomy Patients, Louisa Ustrzynski

Doctor of Nursing Practice Projects

Complications from craniotomy surgery can range from 8-33%, leading to prolonged hospital stays, increased costs, increased risks for complications, and decreased satisfaction. An extensive literature was conducted highlighting Enhanced Recovery After Surgery (ERAS) protocol enhances patient outcomes by emphasizing education, early mobilization, pain management, and proper medication use before surgery. This quality improvement project focused on implementing preoperative and postoperative education in a tertiary hospital outpatient setting targeting adults undergoing craniotomy surgery. The process was implemented by a preoperative checklist and education materials to aid in educating patients on ERAS protocol to decrease the length of stay and increase patient …