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2023

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Understanding The Field And Frequency Dependence Of Rf Loss In Srf Cavities, Pashupati Dhakal, G. Ciovati, Alex V. Gurevich, Bashu D. Khanal Jan 2023

Understanding The Field And Frequency Dependence Of Rf Loss In Srf Cavities, Pashupati Dhakal, G. Ciovati, Alex V. Gurevich, Bashu D. Khanal

Physics Faculty Publications

SRF cavities subjected to heat treatment below 200 °C in the presence of nitrogen showed an improvement in quality factor while maintaining an accelerating gradient above 25 MV/m. Here, we report the rf performance of several single-cell superconducting radio frequency cavities with frequency ranging from 0.75 - 3.0 GHz subjected to low temperature heat treatment in nitrogen environment. The cavities were treated at temperature 120 - 175 oC for 24 - 48 hours in low partial pressure of ultra-pure nitrogen gas. The improvement in Q₀ with Q-rise was observed when nitrogen gas was injected ~300 °C during the furnace treatment. …


Numerical Calculations Of Superheating Field In Superconductors With Nanostructured Surfaces, M.R.P. Walive Pathiranage, A. Gurevich Jan 2023

Numerical Calculations Of Superheating Field In Superconductors With Nanostructured Surfaces, M.R.P. Walive Pathiranage, A. Gurevich

Physics Faculty Publications

We re­port cal­cu­la­tions of a dc su­per­heat­ing field Hs in su­per­con­duc­tors with nanos­truc­tured sur­faces. Par­tic­u­larly, we per­formed nu­mer­i­cal sim­u­la­tions of the Ginzburg-Lan­dau (GL) equa­tions for a su­per­con­duc­tor with an in­ho­mo­ge­neous pro­file of im­pu­rity con­cen­tra­tion, a thin su­per­con­duct­ing layer on top of an­other su­per­con­duc­tor, and S-I-S mul­ti­lay­ers. The su­per­heat­ing field was cal­cu­lated tak­ing into ac­count the in­sta­bil­ity of the Meiss­ner state at a fi­nite wave­length along the sur­face de­pend­ing on the value of the GL pa­ra­me­ter. Sim­u­la­tions were done for the ma­te­ri­als pa­ra­me­ters of Nb and Nb₃Sn at dif­fer­ent val­ues of the GL pa­ra­me­ter and the mean free paths. We show …


Two Approaches To Equality, With Implications For Grutter, Keith N. Hylton Jan 2023

Two Approaches To Equality, With Implications For Grutter, Keith N. Hylton

Faculty Scholarship

The question “what is equality?”, applied to the distribution of resources across races, suggests the following answer: when there appears to be no need for a policy that focuses on improving the welfare of one race relative to another. There is another way to approach the same question: equality is when traditionally-recognized paths to advancement do not give preference to or disadvantage an individual because of his race. Notice the difference here is between end-state and process-based notions of equality, a distinction Nozick emphasized in his examination of justice in distribution. Nozick rejected end-state theories of justice in distribution. I …


Quantum Computations Of The O(3) Model Using Qumodes, R. Jha, Felix Ringer, G. Siopsis, Shane Thompson Jan 2023

Quantum Computations Of The O(3) Model Using Qumodes, R. Jha, Felix Ringer, G. Siopsis, Shane Thompson

Physics Faculty Publications

We express the discrete 1+1-dimensional O(3) non-linear sigma model (NLσM) in a form well-suited for the continuous variable approach to quantum computing. Within the Schwinger boson formulation, we need two qumodes (quantum-mechanical oscillators) at each lattice site. We envision that it might be possible to reach the scaling regime of this model and observe asymptotic freedom on near-term photonic quantum devices in the coming decade.


Simulations Of Radiations Reaction In Inverse Compton Scattering, E. Breen, E. Rogers, E. Johnson, B. Terzić, G. Krafft, G. Wilson Jan 2023

Simulations Of Radiations Reaction In Inverse Compton Scattering, E. Breen, E. Rogers, E. Johnson, B. Terzić, G. Krafft, G. Wilson

Physics Faculty Publications

The effect of radiation reaction is often negligible in inverse Compton scattering. However, in the nonlinear Compton regime, at high laser fields and high electron beam energies where electron recoil must be properly accounted for, there is experimental data which demonstrates the onset of radiation reaction * . We model the radiation reaction as a series of emissions from individual electrons with decreasing energy. This allows us to use the code we previously developed for simulating single-emission inverse Compton scattering events ** . We use the new code to simulate the experiment reported in Cole et al. 2018, and to …


Deeply Virtual Compton Scattering Using A Positron Beam In Hall C, V. Berdnikov, A. Camsonne, M. Carmignotto, R. Ent, J. Grames, D. Higinbotham, C. Keppel, M. Mccaughan, P. Paremuzyan, B. Sawatzky, A. Somov, B. Wojtsekhowski, S. Wood, C. Zorn, R. Dupré, M. Ehrhart, M. Guidal, S. Habet, A. Hobart, D. Marchand, C. Muñoz Camacho, S. Niccolai, E. Voutier, M. Mazouz, T. Horn, G. Kalicy, M. Muhoza, I. Pegg, R. Trotta, A. Asaturyan, A. Mkrtchyan, H. Mkrtchyan, V. Tadevosyan, H. Voskanyan, S. Zhamkochyan, M. Amaryan, C. Hyde, M. Kerver, J. Murphy, J. Roche, P. Markowitz, A. Afanasev, W. J. Briscoe, I. Strakovsky, M. Boer, T. Forest, J.R.M. Annand, D. J. Hamilton, B. Mckinnon, D. Day, M. A. I. Fernando, D. Keller, R. Rondon, J. Zhang, K. Brinkmann, S. Diehl, R. Novotny, P. Gueye, V. Bellini, D. Dutta, E. Kinney, P. Nadel-Turonski, G. Niculescu, S. Sirca, I. Albayrak, M. Defurne, Z. Huang, Z. Ye Jan 2023

Deeply Virtual Compton Scattering Using A Positron Beam In Hall C, V. Berdnikov, A. Camsonne, M. Carmignotto, R. Ent, J. Grames, D. Higinbotham, C. Keppel, M. Mccaughan, P. Paremuzyan, B. Sawatzky, A. Somov, B. Wojtsekhowski, S. Wood, C. Zorn, R. Dupré, M. Ehrhart, M. Guidal, S. Habet, A. Hobart, D. Marchand, C. Muñoz Camacho, S. Niccolai, E. Voutier, M. Mazouz, T. Horn, G. Kalicy, M. Muhoza, I. Pegg, R. Trotta, A. Asaturyan, A. Mkrtchyan, H. Mkrtchyan, V. Tadevosyan, H. Voskanyan, S. Zhamkochyan, M. Amaryan, C. Hyde, M. Kerver, J. Murphy, J. Roche, P. Markowitz, A. Afanasev, W. J. Briscoe, I. Strakovsky, M. Boer, T. Forest, J.R.M. Annand, D. J. Hamilton, B. Mckinnon, D. Day, M. A. I. Fernando, D. Keller, R. Rondon, J. Zhang, K. Brinkmann, S. Diehl, R. Novotny, P. Gueye, V. Bellini, D. Dutta, E. Kinney, P. Nadel-Turonski, G. Niculescu, S. Sirca, I. Albayrak, M. Defurne, Z. Huang, Z. Ye

Physics Faculty Publications

We propose to use the High Momentum Spectrometer of Hall C combined with Neutral Particle Spectrometer (NPS) to perform high precision measurement of the deeply virtual compton scattering (DVCS) cross section using a beam of positrons. The combination of measurements with oppositely charged incident beams is the only unambiguous way to disentange the contribution of the DVCS² term in the photon electroproduction cross section from its interference with the Bethe-Heitler amplitude. This provies a stronger way to constrain the Generalized Parton Distributions of the nucleon. A range of kinematics accessible with an 11 GeV beam off an unpolarized proton target …


Development Of A Novel Readout Concept For An Eic Dirc, K. Dehmelt, A. Deshpande, R. Dzhygadlo, T. K. Hemmick, Md. I. Hossain, C. E. Hyde, Y. Ilieva, G. Kalicy, P. Nadel-Turonski, C. Schwarz, J. Schwiening, N. Shankman, J. Stevens, N. Wickramaarachchi, C. Woody Jan 2023

Development Of A Novel Readout Concept For An Eic Dirc, K. Dehmelt, A. Deshpande, R. Dzhygadlo, T. K. Hemmick, Md. I. Hossain, C. E. Hyde, Y. Ilieva, G. Kalicy, P. Nadel-Turonski, C. Schwarz, J. Schwiening, N. Shankman, J. Stevens, N. Wickramaarachchi, C. Woody

Physics Faculty Publications

The objective of this program is to pursue opportunities to reduce the material budget and the cost of the DIRC counter for the EIC, without loss of performance, by investigating fundamental DIRC performance limits and new optical configurations. The barrel high-performance DIRC (hpDIRC) has been adopted for the ePIC detector and is an attractive solution for Detector-2. In this program, we study the DIRC performance with an innovative optical configuration consisting of narrow, thin radiator bars coupled to wide plates, focusing lenses, and small expansion volume prisms. The outcomes of these studies would be applicable to both ePIC and, in …


The New Pornography Wars, Julie A. Dahlstrom Jan 2023

The New Pornography Wars, Julie A. Dahlstrom

Faculty Scholarship

The world’s largest online pornography conglomerate, MindGeek, has come under fire for the publishing of “rape videos,” child pornography, and nonconsensual pornography on its website, Pornhub. As in the “pornography wars” of the 1970s and 1980s, lawyers and activists have now turned to civil remedies and filed creative anti-trafficking lawsuits against MindGeek and third parties, like payment processing company, Visa. These lawsuits seek not only to achieve legal accountability for online sex trafficking but also to reframe a broader array of online harms as sex trafficking.

This Article explores what these new trafficking lawsuits mean for the future regulation of …


Analytic And Numerical Calculation Of Collider Luminosity With Crab Dynamics, H. Huang, T. Satogata, Y. Zhang, Y. Roblin, F. Lin, S. Zhao Jan 2023

Analytic And Numerical Calculation Of Collider Luminosity With Crab Dynamics, H. Huang, T. Satogata, Y. Zhang, Y. Roblin, F. Lin, S. Zhao

Physics Faculty Publications

For an integral part of electron-ion collider (EIC) design, the crab crossing scheme provides a head-on collision for beams with a nonzero crossing angle. Recently we provided a framework for accurate numerical simulations of beam-beam effects with crabbing crossing dynamics. The framework was implemented in a simulation code package named “CASA BeamBeam”. We offer com-prehensive formulas for calculation of collider luminosity for various cases in the code package. The luminosity calculation module of CASA Beam-Beam now includes the hourglass effect, the beam-tilt effects and the beam offset effect. The benchmarking results show good agreement between the numerical calculation and analytic …


Numerical Simulations Of Radiation Reaction Using Lorentz-Abraham-Dirac Formalism, E. Rogers, B. Terzic, E. Breen, E. Johnson, G. Krafft Jan 2023

Numerical Simulations Of Radiation Reaction Using Lorentz-Abraham-Dirac Formalism, E. Rogers, B. Terzic, E. Breen, E. Johnson, G. Krafft

Physics Faculty Publications

An accelerating charged particle emits electromagnetic radiation. The motion of the particle is further damped via self-interaction with its own radiation. For relativistic particles, the subsequent motion is described via a correction to the Lorentz force, known as the Lorentz-Abraham-Dirac force. The aim of this research is to use the Lorentz-Abraham-Dirac force to computationally simulate the radiation damping that occurs during nonlinear inverse Compton scattering. We build on our previous work and the code which simulates single-emission inverse Compton scattering to incorporate the effect of multiple emissions, thereby modeling the radiation reaction.


The Ghosts Of Chevron Present And Future, Gary S. Lawson Jan 2023

The Ghosts Of Chevron Present And Future, Gary S. Lawson

Faculty Scholarship

In the October 2021 term, the Supreme Court decided six cases involving federal agency interpretations of statutes, at least five of which seemingly implicated the Chevron doctrine and several of which explicitly turned on applications of Chevron in the lower courts. But while the Chevron doctrine has dominated federal administrative law for nearly four decades, not a single majority opinion during the term even cited Chevron. Three of those cases formalized the so-called “major questions” doctrine, which functions essentially as an anti-Chevron doctrine by requiring clear congressional statements of authority to justify agency action on matters of great legal and …


Questions Of Intellectual Property And Fundamental Values In The Digital Age, Jessica Silbey Jan 2023

Questions Of Intellectual Property And Fundamental Values In The Digital Age, Jessica Silbey

Faculty Scholarship

Today's intellectual property debates, in both law and the larger society, are a bellwether of changing justice needs in the twenty-first century. As the digital age democratizes technological opportunities, it brings intellectual property law into mainstream everyday culture. This generates debates about the relationship between the constitutional interest in "the progress of science and useful arts" and other fundamental values, such as equality, privacy, and distributive justice. These values, which were not explicitly part of intellectual property regimes in prior eras, are especially challenged in today's internet world.

The article (which was presented as the annual Nies Lecture in April …


Optimizing Constraint Selection In A Design Verification Environment For Efficient Coverage Closure, Vanessa Cooper Jan 2023

Optimizing Constraint Selection In A Design Verification Environment For Efficient Coverage Closure, Vanessa Cooper

CCAC Theses and Dissertations

No abstract provided.


Integrating The Spatial Pyramid Pooling Into 3d Convolutional Neural Networks For Cerebral Microbleeds Detection, Andre Accioly Veira Jan 2023

Integrating The Spatial Pyramid Pooling Into 3d Convolutional Neural Networks For Cerebral Microbleeds Detection, Andre Accioly Veira

CCAC Theses and Dissertations

Cerebral microbleeds (CMB) are small foci of chronic blood products in brain tissues that are critical markers for cerebral amyloid angiopathy. CMB increases the risk of symptomatic intracerebral hemorrhage and ischemic stroke. CMB can also cause structural damage to brain tissues resulting in neurologic dysfunction, cognitive impairment, and dementia. Due to the paramagnetic properties of blood degradation products, CMB can be better visualized via susceptibility-weighted imaging (SWI) than magnetic resonance imaging (MRI).CMB identification and classification have been based mainly on human visual identification of SWI features via shape, size, and intensity information. However, manual interpretation can be biased. Visual screening …


Editorial: Perspectives On Ptsd And Its Treatment, Jacklynn M. Fitzgerald, Ashley A. Huggins Jan 2023

Editorial: Perspectives On Ptsd And Its Treatment, Jacklynn M. Fitzgerald, Ashley A. Huggins

Psychology Faculty Research and Publications

No abstract provided.


Editorial: Insights In Neurocognitive Aging And Behavior: 2021, Kristy A. Nielson, Ian M. Mcdonough, Anja Soldan Jan 2023

Editorial: Insights In Neurocognitive Aging And Behavior: 2021, Kristy A. Nielson, Ian M. Mcdonough, Anja Soldan

Psychology Faculty Research and Publications

In recent years, exceptional scientific achievements have led to major advancements in the fast-growing field of neurocognitive aging and behavior. In this inaugural collection, Insights in Neurocognitive Aging and Behavior: 2021, we sought to highlight the latest advancements and challenges for the current state of knowledge and future directions in aging neuroscience in the neurocognitive arena. Here we outline the contributions and implications for future research of the 15 papers in this topic collection across four important research areas: (1) novel approaches to identifying and tracking brain aging and impending cognitive decline; (2) neurocognitive markers of risks for Alzheimer’s disease …


Large-Scale Network Connectivity And Cognitive Function Changes After Exercise Training In Older Adults With Intact Cognition And Mild Cognitive Impairment, Junyeon Won, Kristy A. Nielson, J. Carson Smith Jan 2023

Large-Scale Network Connectivity And Cognitive Function Changes After Exercise Training In Older Adults With Intact Cognition And Mild Cognitive Impairment, Junyeon Won, Kristy A. Nielson, J. Carson Smith

Psychology Faculty Research and Publications

Background:

Despite growing evidence regarding the association between exercise training (ET) and functional brain network connectivity, little is known about the effects of ET on large-scale within- and between-network functional connectivity (FC) of core brain networks.

Objective:

We investigated the effects of ET on within- and between-network functional connectivity of the default mode network (DMN), frontoparietal network (FPN), and salience network (SAL) in older adults with intact cognition (CN) and older adults diagnosed with mild cognitive impairment (MCI). The association between ET-induced changes in FC and cognitive performance was examined.

Methods:

33 older adults (78.0±7.0 years; 16 MCI and 17 …


Learning Performance Efficiency Of College Basketball Players Using Tvae, Nasim Yahyasoltani, Priyanka Annapureddy, Manzur Rahman Farazi Jan 2023

Learning Performance Efficiency Of College Basketball Players Using Tvae, Nasim Yahyasoltani, Priyanka Annapureddy, Manzur Rahman Farazi

Computer Science Faculty Research and Publications

Monitoring workload is essential to evaluate possibility of fatigue or injuries and overall performance of the players. Large player’s workload in any game including basketball can contribute to the stress and fatigue and overloaded players may get exhausted and exhibit burnout symptoms, which eventually result in their lower efficiency in the game. This paper aims at predicting the efficiency of the basketball players in all positions (guard, forward and center) based on their workload information. Machine learning (ML) methods for regression and classification are applied to the dataset for predictive modelling of the variables. The analysis includes: (i) one-model for …


Power, Stress, And Uncertainty: Experiences With And Attitudes Toward Workplace Surveillance During A Pandemic, Jessica Vitak, Michael Zimmer Jan 2023

Power, Stress, And Uncertainty: Experiences With And Attitudes Toward Workplace Surveillance During A Pandemic, Jessica Vitak, Michael Zimmer

Computer Science Faculty Research and Publications

There is a rich literature on technology’s role in facilitating employee monitoring in the workplace. The COVID-19 pandemic created many challenges for employers, and many companies turned to new forms of monitoring to ensure remote workers remained productive; however, these technologies raise important privacy concerns as the boundaries between work and home are further blurred. In this paper, we present findings from a study of 645 US workers who spent at least part of 2020 working remotely due to the pandemic. We explore how their work experiences (job satisfaction, stress, and security) changed between January and November 2020, as well …


A Study Of The Effect Of Types Of Organizational Culture On Information Security Procedural Countermeasures, Sheri James Jan 2023

A Study Of The Effect Of Types Of Organizational Culture On Information Security Procedural Countermeasures, Sheri James

CCAC Theses and Dissertations

This study examined the impact of specific organizational cultures on information security procedural countermeasures (ISPC). With increasing security incidents and data breaches, organizations acknowledge that people are their greatest asset as well as a vulnerability. Previous research into information security procedural controls has centered on behavioral, cognitive, and social theories; some literature incorporates general notions of organization culture yet there is still an absence in socio-organizational studies dedicated to elucidating how information security policy (ISP) compliance can be augmented by implementing comprehensive security education, training, and awareness (SETA) programs focusing on education, training, and awareness initiatives.

A theoretical model was …


Comparing Phishing Training And Campaign Methods For Mitigating Malicious Emails In Organizations, Jackie Christopher Scott Jan 2023

Comparing Phishing Training And Campaign Methods For Mitigating Malicious Emails In Organizations, Jackie Christopher Scott

CCAC Theses and Dissertations

Although there have been numerous technological advancements in the last several years, there continues to be a real threat as it pertains to social engineering, especially phishing, spear-phishing, and Business Email Compromise (BEC). While the technologies to protect corporate employees and network borders have gotten better, there are still human elements to consider. No technology can protect an organization completely, so it is imperative that end users are provided with the most up-to-date and relevant Security Education, Training, and Awareness (SETA). Phishing, spear-phishing, and BEC are three primary vehicles used by attackers to infiltrate corporate networks and manipulate end users …


An Investigation Of Methods For Improving Spatial Invariance Of Convolutional Neural Networks For Image Classification, David Noel Jan 2023

An Investigation Of Methods For Improving Spatial Invariance Of Convolutional Neural Networks For Image Classification, David Noel

CCAC Theses and Dissertations

Convolutional Neural Networks (CNNs) have achieved impressive results on complex visual tasks such as image recognition. They are commonly assumed to be spatially invariant to small transformations of their input images. Spatial invariance is a fundamental property that characterizes how a model reacts to input transformations, i.e., its generalizability - and deep networks that can robustly classify objects placed in different orientations or lighting conditions have the property of invariance. However, several authors have recently shown that this is not the case, and that slight rotations, translations, or rescaling of their input images significantly reduce the network’s predictive accuracy. Furthermore, …


Adversarial Training Of Deep Neural Networks, Anabetsy Termini Jan 2023

Adversarial Training Of Deep Neural Networks, Anabetsy Termini

CCAC Theses and Dissertations

Deep neural networks used for image classification are highly susceptible to adversarial attacks. The de facto method to increase adversarial robustness is to train neural networks with a mixture of adversarial images and unperturbed images. However, this method leads to robust overfitting, where the network primarily learns to recognize one specific type of attack used to generate the images while remaining vulnerable to others after training. In this dissertation, we performed a rigorous study to understand whether combinations of state of the art data augmentation methods with Stochastic Weight Averaging improve adversarial robustness and diminish adversarial overfitting across a wide …


A Pleasure To Burn: How First Amendment Jurisprudence On Book Banning Bolsters White Supremacy, Amy Anderson Jan 2023

A Pleasure To Burn: How First Amendment Jurisprudence On Book Banning Bolsters White Supremacy, Amy Anderson

Mitchell Hamline Law Review

No abstract provided.


Constitutionality Of Reparations For Native Americans: Confronting The Boarding Schools, Monica Shaffer Jan 2023

Constitutionality Of Reparations For Native Americans: Confronting The Boarding Schools, Monica Shaffer

Mitchell Hamline Law Review

No abstract provided.


Transforming The Minneapolis Police Department To Conform With The Rule Of Law: Reform Or Abolition, James Roth Jan 2023

Transforming The Minneapolis Police Department To Conform With The Rule Of Law: Reform Or Abolition, James Roth

Mitchell Hamline Law Review

No abstract provided.


Phase I Study Of Anti-Epidermal Growth Factor Receptor Antibody-Drug Conjugate Serclutamab Talirine: Safety, Pharmacokinetics, And Antitumor Activity In Advanced Glioblastoma, Benedito A Carneiro, Saiama N Waqar, Et Al. Jan 2023

Phase I Study Of Anti-Epidermal Growth Factor Receptor Antibody-Drug Conjugate Serclutamab Talirine: Safety, Pharmacokinetics, And Antitumor Activity In Advanced Glioblastoma, Benedito A Carneiro, Saiama N Waqar, Et Al.

2020-Current year OA Pubs

BACKGROUND: Serclutamab talirine (Ser-T, formerly ABBV-321) is an antibody-drug conjugate consisting of an antibody (AM-1-ABT-806) directed against activated epidermal growth factor receptor (EGFR) and a pyrrolobenzodiazepine dimer. We investigated Ser-T monotherapy in a phase I, first-in-human, dose-escalation, and dose-expansion study in patients with advanced solid tumors associated with EGFR overexpression.

METHODS: Eligible patients (≥18 years) had advanced, histologically confirmed solid tumors associated with EGFR overexpression (centralized testing). Patients received Ser-T intravenously once every 4 weeks (Q4W; 5-50 μg/kg) in the dose-escalation phase. Herein, preliminary antitumor activity at the recommended phase II dose (RP2D) is reported only for patients with glioblastoma …


Substance Use Treatment Utilization Among Women With And Without Human Immunodeficiency Virus, Ayako W Fujita, Aditi Ramakrishnan, Et Al. Jan 2023

Substance Use Treatment Utilization Among Women With And Without Human Immunodeficiency Virus, Ayako W Fujita, Aditi Ramakrishnan, Et Al.

2020-Current year OA Pubs

BACKGROUND: Substance use (SU) contributes to poor health outcomes, yet limited data exist to inform strategies to optimize SU treatment among persons with human immunodeficiency virus (HIV). We describe SU and SU treatment utilization among women with and without HIV in the Women's Interagency HIV Study (WIHS).

METHODS: We included data from women enrolled in WIHS from 2013 to 2020. Current SU was self-reported, nonmedical use of drugs in the past year, excluding use of only marijuana. SU treatment utilization was self-reported use of a drug treatment program in the past year. Multivariable regression models were used to investigate associations …


Public Mental Health During And After The Sars-Cov-2 Pandemic: Opportunities For Intervention, Melissa M Karnaze, Brent M Kious, Lindsay Z Feuerman, Sarah Classen, Jill O Robinson, Cinnamon S Bloss, Amy L Mcguire Jan 2023

Public Mental Health During And After The Sars-Cov-2 Pandemic: Opportunities For Intervention, Melissa M Karnaze, Brent M Kious, Lindsay Z Feuerman, Sarah Classen, Jill O Robinson, Cinnamon S Bloss, Amy L Mcguire

Center for Medical Ethics and Health Policy Staff Publications

Importance: During the pandemic, the number of United States adults reporting clinically significant symptoms of anxiety and depression sky-rocketed, up from 11% in 2020 to more than 40% in 2021. Our current mental healthcare system cannot adequately accommodate the current crisis; it is therefore important to identify opportunities for public mental health interventions.

Objective: Assess whether modifiable emotional factors may offer a point of intervention for the mental health crisis.

Design setting and participants: From January 13 to 15, 2022, adults living in the United States were recruited via Amazon Mechanical Turk to complete an anonymous survey.

Main outcomes and …


Biological Embedding Of Early Trauma: The Role Of Higher Prefrontal Synaptic Strength, Amanda J F Tamman, Lihong Jiang, Christopher L Averill, Graeme F Mason, Lynnette A Averill, Chadi G Abdallah Jan 2023

Biological Embedding Of Early Trauma: The Role Of Higher Prefrontal Synaptic Strength, Amanda J F Tamman, Lihong Jiang, Christopher L Averill, Graeme F Mason, Lynnette A Averill, Chadi G Abdallah

Staff and Researcher Publications

Background: Early trauma predicts poor psychological and physical health. Glutamatergic synaptic processes offer one avenue for understanding this relationship, given glutamate's abundance and involvement in reward and stress sensitivity, emotion, and learning. Trauma-induced glutamatergic excitotoxicity may alter neuroplasticity and approach/avoidance tendencies, increasing risk for psychiatric disorders. Studies examine upstream or downstream effects instead of glutamatergic synaptic processes in vivo, limiting understanding of how trauma affects the brain.Objective: In a pilot study using a previously published data set, we examine associations between early trauma and a proposed measure of synaptic strength in vivo in one of the largest human …