Digital Commons Network^™

The Relationship Of Trait-Like Compassion With Epigenetic Aging: The Population-Based Prospective Young Finns Study, Henrik Dobewall, Liisa Keltikangas-Järvinen, Saara Marttila, Pashupati P Mishra, Aino Saarinen, C Robert Cloninger, Igor Zwir, Mika Kähönen, Mikko Hurme, Olli Raitakari, Terho Lehtimäki, Mirka Hintsanen

2020-Current year OA Pubs

INTRODUCTION: Helping others within and beyond the family has been related to living a healthy and long life. Compassion is a prosocial personality trait characterized by concern for another person who is suffering and the motivation to help. The current study examines whether epigenetic aging is a potential biological mechanism that explains the link between prosociality and longevity.

METHODS: We used data from the Young Finns Study that follows six birth-cohorts from age 3-18 to 19-49. Trait-like compassion for others was measured with the Temperament and Character Inventory in the years 1997 and 2001. Epigenetic age acceleration and telomere length …

The In Vivo Study Of Cardiac Mechano-Electric And Mechano-Mechanical Coupling During Heart Development In Zebrafish, Jonathan S Baillie, Alex Gendernalik, Deborah M Garrity, David Bark Jr, T Alexander Quinn

2020-Current year OA Pubs

In the adult heart, acute adaptation of electrical and mechanical activity to changes in mechanical load occurs

Qunex-An Integrative Platform For Reproducible Neuroimaging Analytics, Jie Lisa Ji, Matthew F Glasser, Michael P Harms, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Neuroimaging technology has experienced explosive growth and transformed the study of neural mechanisms across health and disease. However, given the diversity of sophisticated tools for handling neuroimaging data, the field faces challenges in method integration, particularly across multiple modalities and species. Specifically, researchers often have to rely on siloed approaches which limit reproducibility, with idiosyncratic data organization and limited software interoperability.

METHODS: To address these challenges, we have developed Quantitative Neuroimaging Environment & Toolbox (QuNex), a platform for consistent end-to-end processing and analytics. QuNex provides several novel functionalities for neuroimaging analyses, including a "turnkey" command for the reproducible deployment …

The Cerebrospinal Fluid Immune Cell Landscape In Animal Models Of Multiple Sclerosis, Gregory F Wu

2020-Current year OA Pubs

The fluid compartment surrounding the central nervous system (CNS) is a unique source of immune cells capable of reflecting the pathophysiology of neurologic diseases. While human clinical and experimental studies often employ cerebrospinal fluid (CSF) analysis, assessment of CSF in animal models of disease are wholly uncommon, particularly in examining the cellular component. Barriers to routine assessment of CSF in animal models of multiple sclerosis (MS) include limited sample volume, blood contamination, and lack of feasible longitudinal approaches. The few studies characterizing CSF immune cells in animal models of MS are largely outdated, but recent work employing transcriptomics have been …

Mora And Ensembletfpredictor: An Ensemble Approach To Reveal Functional Transcription Factor Regulatory Networks, Kevin Boyer, Louis Li, Tiandao Li, Bo Zhang, Guoyan Zhao

2020-Current year OA Pubs

MOTIVATION: Our study aimed to identify biologically relevant transcription factors (TFs) that control the expression of a set of co-expressed or co-regulated genes.

RESULTS: We developed a fully automated pipeline, Motif Over Representation Analysis (MORA), to detect enrichment of known TF binding motifs in any query sequences. MORA performed better than or comparable to five other TF-prediction tools as evaluated using hundreds of differentially expressed gene sets and ChIP-seq datasets derived from known TFs. Additionally, we developed EnsembleTFpredictor to harness the power of multiple TF-prediction tools to provide a list of functional TFs ranked by prediction confidence. When applied to …

Whole-Brain Imaging Of Freely-Moving Zebrafish, Hamid Hasani, Jipeng Sun, Shuyu I Zhu, Qiangzhou Rong, Florian Willomitzer, Rumelo Amor, Gail Mcconnell, Oliver Cossairt, Geoffrey J Goodhill

2020-Current year OA Pubs

One of the holy grails of neuroscience is to record the activity of every neuron in the brain while an animal moves freely and performs complex behavioral tasks. While important steps forward have been taken recently in large-scale neural recording in rodent models, single neuron resolution across the entire mammalian brain remains elusive. In contrast the larval zebrafish offers great promise in this regard. Zebrafish are a vertebrate model with substantial homology to the mammalian brain, but their transparency allows whole-brain recordings of genetically-encoded fluorescent indicators at single-neuron resolution using optical microscopy techniques. Furthermore zebrafish begin to show a complex …

Precision Neuromodulation: Promises And Challenges Of Spinal Stimulation For Multi-Modal Rehabilitation, Maria F Bandres, Jefferson L Gomes, Gerson N Moreno Romero, Avery R Twyman, Jacob Graves Mcpherson

2020-Current year OA Pubs

Spinal cord injury results in multiple, simultaneous sensorimotor deficits. These include, but are not limited to, full or partial paralysis of muscles below the lesion, muscle spasms, spasticity, and neuropathic pain. Bowel, bladder, and sexual dysfunction are also prevalent. Yet, the majority of emerging spinal stimulation-based therapies focus on a single issue: locomotor rehabilitation. Despite the enormous potential of these translational advances to transform the lives of people living with spinal cord injury, meaningful recovery in other domains deemed critical priorities remains lacking. Here, we highlight the importance of considering the diverse patterns of neural transmission that underlie clinically similar …

Vigorous-Intensity Exercise As A Modulator Of Cardiac Adipose Tissue In Women With Obesity: A Cross-Sectional And Randomized Pilot Study, Sumsen Thapa, Bharath S Selvaraj, Paige N Davis, Bryan Smith, Amy H Givan, Jose A Perez-Rivera, Pamela K Woodard, Jon D Klingensmith, Maria Fernandez-Del-Valle

2020-Current year OA Pubs

Cardiac adipose tissue (CAT) has become an important target for the reduction of disease risk. Supervised exercise programs have shown potential to "significantly" reduce CAT; however, the impact of different exercise modalities is not clear, and the relationships between CAT, physical activity (PA) levels and fitness (PFit) remain unknown. Therefore, the purpose of this study was to analyze the relationships between CAT, PA and PFit, and to explore the effects of different exercise modalities in a group of women with obesity. A total of 26 women (age: 23.41 ± 5.78 years-old) were enrolled in the cross-sectional study. PA, cardiorespiratory fitness, …

Down Syndrome And Alzheimer's Disease: A Scoping Review Of Functional Performance And Fall Risk, Selena E Washington, Emily Cler, Cameron Lowery, Susan L Stark

2020-Current year OA Pubs

INTRODUCTION: Alzheimer's disease (AD) occurs in aging adults with Down syndrome (DS) at a higher prevalence and an earlier age than in typical aging adults. As with the general aging adult population, there is an urgent need to understand the preclinical and early phases of AD progression in the adult population with DS. The aim of this scoping review was to synthesize the current state of the evidence and identify gaps in the literature regarding functional activity performance and falls and their significance to disease staging (i.e., mild, moderate, and severe defined staging criteria) in relation to Alzheimer's disease and …

Public Feminisms: From Academy To Community, Carrie N. Baker, Aviva Dove-Viebahn

Open Educational Resources: Textbooks

The field of feminist studies grew from the U.S. women’s movements of the 1960s and 1970s and has continued to be deeply connected to ongoing movements for social justice. As educational institutions are increasingly seeing public scholarship and community engagement as relevant and fruitful complements to traditional academic work, feminist scholars have much to offer in demonstrating different ways to inform and interact with various communities. In this collection, a diverse range of feminist scholar-activists write about the dynamic and varied methods they use to reach beyond traditional classrooms and scholarly journals to share their work with the public. Here …

Organic Chemistry Ii, Layne Morsch, Steven Farmer, Krista Cunningham, Zachery Sharrett, Kevin M. Shea

Open Educational Resources: Textbooks

This text has many contributors. It was adapted for use in CHM 223 at Smith College by Kevin Shea with the assistance of a Smith College Library OER Incentive Grant.

Scale-Free Behavioral Dynamics Directly Linked With Scale-Free Cortical Dynamics, Sabrina A. Jones, Jacob H. Barfield, V. Kindler Norman, Woodrow L. Shew

Physics Faculty Publications and Presentations

Naturally occurring body movements and collective neural activity both exhibit complex dynamics, often with scale-free, fractal spatiotemporal structure. Scale-free dynamics of both brain and behavior are important because each is associated with functional benefits to the organism. Despite their similarities, scale-free brain activity and scale-free behavior have been studied separately, without a unified explanation. Here, we show that scale-free dynamics of mouse behavior and neurons in the visual cortex are strongly related. Surprisingly, the scale-free neural activity is limited to specific subsets of neurons, and these scale-free subsets exhibit stochastic winner-take-all competition with other neural subsets. This observation is inconsistent …

Introducing Sonhr-Reporting Guidelines For Social Networks In Health Research, Douglas A. Luke, Edward Tsai, Bobbi J. Carothers, Sara Malone, Beth Prusaczyk, Todd B. Combs, Mia T Vogel, Jennifer Watling Neal, Zachary P. Neal

2020-Current year OA Pubs

OBJECTIVE: The overall goal of this work is to produce a set of recommendations (SoNHR-Social Networks in Health Research) that will improve the reporting and dissemination of social network concepts, methods, data, and analytic results within health sciences research.

METHODS: This study used a modified-Delphi approach for recommendation development consistent with best practices suggested by the EQUATOR health sciences reporting guidelines network. An initial set of 28 reporting recommendations was developed by the author team. A group of 67 (of 147 surveyed) experienced network and health scientists participated in an online feedback survey. They rated the clarity and importance of …

Rare Predicted Loss-Of-Function Variants Of Type I Ifn Immunity Genes Are Associated With Life-Threatening Covid-19, Daniela Matuozzo, Megan A. Cooper, Et Al.

2020-Current year OA Pubs

No abstract provided.

Development Of A Social And Environmental Determinants Of Health Informatics Maturity Model, Juan C Espinoza, Shruti Sehgal, Jimmy Phuong, Neil Bahroos, Justin Starren, Adam Wilcox, Daniella Meeker

2020-Current year OA Pubs

INTRODUCTION: Integrating social and environmental determinants of health (SEDoH) into enterprise-wide clinical workflows and decision-making is one of the most important and challenging aspects of improving health equity. We engaged domain experts to develop a SEDoH informatics maturity model (SIMM) to help guide organizations to address technical, operational, and policy gaps.

METHODS: We established a core expert group consisting of developers, informaticists, and subject matter experts to identify different SIMM domains and define maturity levels. The candidate model (v0.9) was evaluated by 15 informaticists at a Center for Data to Health community meeting. After incorporating feedback, a second evaluation round …

Barriers To And Solutions For Representative Inclusion Across The Lifespan And In Life Course Research: The Need For Structural Competency Highlighted By The Covid-19 Pandemic, Madison N Lecroy, Ebony B Carter, Sarah S Farabi, Dominic N Reeds, Et Al.

2020-Current year OA Pubs

Exclusion of special populations (older adults; pregnant women, children, and adolescents; individuals of lower socioeconomic status and/or who live in rural communities; people from racial and ethnic minority groups; individuals from sexual or gender minority groups; and individuals with disabilities) in research is a pervasive problem, despite efforts and policy changes by the National Institutes of Health and other organizations. These populations are adversely impacted by social determinants of health (SDOH) that reduce access and ability to participate in biomedical research. In March 2020, the Northwestern University Clinical and Translational Sciences Institute hosted the "Lifespan and Life Course Research: integrating …

Study Protocol: A Cross-Sectional Survey Of Clinicians To Identify Barriers To Clinical Practice Guideline Implementation In The Assessment And Treatment Of Persistent Tic Disorders, Jaclyn M. Martindale, Harini Sarva, Davide Martino, Donald L. Gilbert, Christos Ganos, Tamara Pringsheim, Kevin J. Black, Irene A. Malaty

2020-Current year OA Pubs

INTRODUCTION: Eight members of the International Parkinson's Disease and Movement Disorders Society Tic and Tourette Syndrome Study Group formed a subcommittee to discuss further barriers to practice guideline implementation. Based on expert opinion and literature review, the consensus was that practice variations continue to be quite broad and that many barriers in different clinical settings might negatively influence the adoption of the American Academy of Neurology and the European Society for the Study of Tourette Syndrome published guidelines.

OBJECTIVES: 1) To identify how clinical practices diverge from the existing American Academy of Neurology and European Society for the Study of …

Promis Physical Function And Pain Interference Scores Correlate With The Lower Extremity Toronto Extremity Salvage Score, Julie Jin, Zachery Hong, Lee Rhea, Douglas J. Mcdonald, Regis J. O'Keefe, Cara A. Cipriano

2020-Current year OA Pubs

UNLABELLED: The Toronto Extremity Salvage Score (TESS) and the National Institutes of Health Patient-Reported Outcomes Measurement Information System (PROMIS) are both utilized to measure patient-reported outcomes in adults with musculoskeletal oncologic conditions. However, the relationship between them has not been studied. We sought to describe a link between Lower Extremity (LE) TESS and PROMIS Physical Function (PF) scores, as well as between LE TESS and Pain Interference (PI) scores, to develop a method for converting scores between TESS and PROMIS and to examine whether TESS and PROMIS captured differences in pain and function between clinically relevant subgroups in our population. …

Factor Structure Of The International Trauma Questionnaire In Trauma Exposed Lgbtq Plus Adults: Role Of Cumulative Traumatic Events And Minority Stress Heterosexist Experiences, Ruby Charak, Ines Cano-Gonzalez, Roman Ronzón-Tirado, Julian D. Ford, Brianna M. Byllesby, Mark Shevlin, Thanos Karatzias, Philip Hyland, Marylene Cloitre

Psychological Science Faculty Publications

Exposure to prolonged and/or multiple types of psychological trauma and stressors has been shown to be more strongly associated with ICD-11 complex posttraumatic stress disorder (CPTSD) than posttraumatic stress disorder (PTSD). Lesbian, gay, bisexual, trans- and queer adults (LGBTQ+) are at a heightened risk of exposure to traumatic events, and minority stressors including harassment, discrimination, rejection by family, and isolation. Objective: To examine the factor structure of the international trauma questionnaire (ITQ), a self-report measure of PTSD and CPTSD, and the associations of cumulative lifetime trauma exposure assessed via the life events checklist and minority stress assessed via the daily …

Understanding Student Perceptions Of Supplemental Instruction: Student Perceptions Of Supplemental Instruction Implemented In Order To Overcome Perceived Skill Deficits, Andrew Miehe

Dissertations and Theses @ UNI

Supplemental instruction has become so prevalent that it is simply a thing educators do to students without the students’ input or their understanding of its purpose. This prevalence combined with a lack of understanding on the part of the students could create problems around programmatic success and student motivation in addition to the potential of limiting access to coursework. Due to the fact that there is not an abundance of research focused on the student perceptions of supplemental instruction there is consensus that this perspective is often absent despite its critical role (Yazzie-Mintz & McCormick, 2012).

The proliferation of supplemental …

Forgotten Grievers: Perspectives On Childhood Grief In The Baptist Church In Kenya, Esther Wambui Kiarie

All Electronic Theses and Dissertations

This project was aimed at developing a ministry care model for grieving children for the Baptist church in Nairobi, Kenya. Three Baptist churches with an active children’s ministry were identified. A study of the spiritual support available to the broken-hearted and the biblical view of children provided this project's biblical and theological foundation. Special attention was given to Psalm 23, John 10:1-21 and Luke 7: 11-17. The researcher discovered that children grievers can receive spiritual comfort, care, and community support to facilitate effective coping and grief resolution. The researcher then reviewed the literature on theories of child grief and bereavement, …

Community School Programming, Timothy D Gilbert

All Electronic Theses and Dissertations

Contemporary educational legislation is pushing a resurgence of historic educational program models to meet historic and contemporary barriers to student and school achievement. School districts, especially in urban centers are faced with increased challenges in meeting needs to ensure their achievement. These challenges include meeting the unique needs of students more frequently affected by barriers created by community poverty. School reform programs such as the Community Schools are being popularized to support underperforming schools, especially those serving high-poverty communities. This project reviewed comprehensive research regarding Community Schools including descriptions of their structures, their features and evidence of their effectiveness. The …

Misidentifying English Language Learners With Learning Disabilities, Suzan Cevheroglu

All Electronic Theses and Dissertations

This thesis explores the multifaceted issue of misidentifying English Language Learners (ELLs) with learning disabilities (LDs) in the educational system. The study begins by delving into the complicated reasons underlying such misidentifications, recognizing the significance of understanding the complex interplay between language acquisition challenges and learning disabilities. Utilizing empirical evidence and conducting an extensive literature review, the research uncovers the intricate factors contributing to the misidentification of ELLs, including linguistic diversity, cultural biases, and the limitations of assessment tools. Following this exploration of the problem's dimensions, the thesis outlines solutions designed to prevent the misidentification of ELLs with LDs. These …

A Rising Tide Photovoice Photobook, Natalie Lord, Catherine M. Ashcraft, Lindsey Williams, Julia Novak-Colwell

Faculty Publications

This document provides the results of the photographic documentation and written narrative portion of the photovoice case study conducted from November, 2021 to March, 2022 by (n=4) research participants. The goal of the Photobook is to share the data collected by the research participants on their experiences as women owning and operating an oyster farm in Maine and New Hampshire.

Financial Strain Of Covid-19 And Its Impact On Willingness-To-Pay For Equine Care, Jada M. Thompson, Michelle Kibler, Jennie L.Z. Ivey

Agricultural Economics and Agribusiness Faculty Publications and Presentations

The novel COVID-19 virus caused a global pandemic disrupting lives, industries, and economies. The result was an impact on prices due to challenges with production and supply chain distribution. This study investigates the financial strain COVID-19 had on equine owners and leasers, what the market for equine care would bear if costs for care increased, and what factors contribute to their willingness to pay (WTP) for increasing cost of equine care. An online survey was distributed for 4 weeks to adult U.S. residents. Respondents reported their involvement in the equine industry, financial response to COVID-19, and responses to …

Projecting Wheat Demand In China And India For 2030 And 2050: Implications For Food Security, Khondoker Abdul Mottaleb, Gideon Kruseman, Aymen Frija, Kai Sonder, Santiago Lopez-Ridaura

Agricultural Economics and Agribusiness Faculty Publications and Presentations

Introduction: The combined populations of China and India were 2.78 billion in 2020, representing 36% of the world population (7.75 billion). Wheat is the second most important staple grain in both China and India. In 2019, the aggregate wheat consumption in China was 96.4 million ton and in India it was 82.5 million ton, together it was more than 35% of the world's wheat that year. In China, in 2050, the projected population will be 1294–1515 million, and in India, it is projected to be 14.89–1793 million, under the low and high-fertility rate assumptions. A question arises as to, what …

Light Auditor: Power Measurement Can Tell Private Data Leakage Through Iot Covert Channels, Woosub Jung, Kailai Cui, Kenneth Koltermann, Junjie Wang, Chunsheng Xin, Gang Zhou

Electrical & Computer Engineering Faculty Publications

Despite many conveniences of using IoT devices, they have suffered from various attacks due to their weak security. Besides well-known botnet attacks, IoT devices are vulnerable to recent covert-channel attacks. However, no study to date has considered these IoT covert-channel attacks. Among these attacks, researchers have demonstrated exfiltrating users' private data by exploiting the smart bulb's capability of infrared emission.

In this paper, we propose a power-auditing-based system that defends the data exfiltration attack on the smart bulb as a case study. We first implement this infrared-based attack in a lab environment. With a newly-collected power consumption dataset, we pre-process …

Ultrasensitive Tapered Optical Fiber Refractive Index, Erem Ujah, Meimei Lai, Gymama Slaughter

Electrical & Computer Engineering Faculty Publications

Refractive index (RI) sensors are of great interest for label-free optical biosensing. A tapered optical fiber (TOF) RI sensor with micron-sized waist diameters can dramatically enhance sensor sensitivity by reducing the mode volume over a long distance. Here, a simple and fast method is used to fabricate highly sensitive refractive index sensors based on localized surface plasmon resonance (LSPR). Two TOFs (l = 5 mm) with waist diameters of 5 µm and 12 µm demonstrated sensitivity enhancement at λ = 1559 nm for glucose sensing (5-45 wt%) at room temperature. The optical power transmission decreased with increasing glucose concentration due …

Mwirgan: Unsupervised Visible-To Mwir Image Translation With Generative Adversarial Network, Mohammad Shahab Uddin, Chiman Kwan, Jiang Li

Electrical & Computer Engineering Faculty Publications

Unsupervised image-to-image translation techniques have been used in many applications, including visible-to-Long-Wave Infrared (visible-to-LWIR) image translation, but very few papers have explored visible-to-Mid-Wave Infrared (visible-to-MWIR) image translation. In this paper, we investigated unsupervised visible-to-MWIR image translation using generative adversarial networks (GANs). We proposed a new model named MWIRGAN for visible-to-MWIR image translation in a fully unsupervised manner. We utilized a perceptual loss to leverage shape identification and location changes of the objects in the translation. The experimental results showed that MWIRGAN was capable of visible-to-MWIR image translation while preserving the object’s shape with proper enhancement in the translated images and …

View Synthesis With Scene Recognition For Cross-View Image Localization, Uddom Lee, Peng Jiang, Hongyi Wu, Chunsheng Xin

Electrical & Computer Engineering Faculty Publications

Image-based localization has been widely used for autonomous vehicles, robotics, augmented reality, etc., and this is carried out by matching a query image taken from a cell phone or vehicle dashcam to a large scale of geo-tagged reference images, such as satellite/aerial images or Google Street Views. However, the problem remains challenging due to the inconsistency between the query images and the large-scale reference datasets regarding various light and weather conditions. To tackle this issue, this work proposes a novel view synthesis framework equipped with deep generative models, which can merge the unique features from the outdated reference dataset with …