Digital Commons Network^™

Protocol: Can Coronary Artery Calcium Score Identified On Thoracic Planning Ct Scans Be Used And Actioned To Identify Cancer Survivors At High Risk Of Cardiac Events: A Feasibility Study In Cancer Survivors Undergoing Radiotherapy In Australia, Jack Dalla Via, Nina Stewart, Mary A. Kennedy, Daniel A. Cehic, Peter Purnell, Joanne Toohey, Jamie Morton, Sabashini K. Ramchand, Joshua R. Lewis, Yvonne Zissiadis

Research outputs 2022 to 2026

INTRODUCTION: A coronary artery calcium (CAC) CT scan can identify calcified plaque and predict risk of future cardiac events. Cancer survivors undergoing thoracic radiotherapy routinely undergo a planning CT scan, which presents a unique opportunity to use already obtained medical imaging to identify those at the highest risk of cardiac events. While radiation therapy is an important modality for many cancer treatments, radiation dose to the heart in thoracic radiotherapy leads to cardiotoxicity and may accelerate pre-existing atherosclerosis. The primary aims of this study are to investigate the feasibility of using CAC scores calculated on thoracic radiotherapy planning CT scans …

Evaluating The Effect Of Symbiodiniacea On Survival, Growth, And Acquisition Of Newly Settled Corals Of Three Caribbean Species, Michael B. Hood

All HCAS Student Capstones, Theses, and Dissertations

Symbiosis between corals and Symbiodiniaceae is critical to coral reef health. However, this mutually beneficial relationship is threatened by a variety of stressors. This study aims to assess if seeding newly settled corals with different species of Symbiodiniaceae promotes differences in survival, growth, and symbiont acquisition in corals. Three reef-building species (Colpophyllia natans, Orbicella faveolata, and Pseudodiploria strigosa) reared in sterile saltwater baths were seeded with one of four Symbiodiniaceae species (Breviolum minutum, Durusdinium trenchii, Fugacium kawagutii, and Symbiodinium microadriaticum). Coral survival, growth, and symbiont acquisition were assessed biweekly during the first two months and monthly …

Revision Endoscopic Gastroplasty: An Overview And Review Of Literature, Basil N. Nduma, Kelly A. Mofor, Jason Tatang, Loica Amougou, Stephen Nkeonye, Princess Chineme, Chukwuyem Ekhator, Solomon Ambe

Health & Biomedical Sciences Faculty Publications

The main aim of this paper was to examine the efficacy and safety of revision endoscopic gastroplasty and some of the adverse events likely to arise from the procedure, as well as the implications for future scholarly research. The study is a systematic review in which the PRISMA protocol was used to govern the article's inclusion and exclusion criteria. The selected studies include those on revising endoscopic gastroplasty's effectiveness and safety. The studies were selected based on multiple parameters. The outcome included weight recidivism, excessive BMI loss, and absolute, total, or percentage weight loss. The outcome of this review confirmed …

Anoctamin 4 Channel Currents Activate Glucose-Inhibited Neurons In The Mouse Ventromedial Hypothalamus During Hypoglycemia, Longlong Tu, Jonathan C. Bean, Yang He, Hailan Liu, Meng Yu, Hesong Liu, Nan Zhang, Na Yin, Junying Han, Nikolas A. Scarcelli, Kristine M. Conde, Mengjie Wang, Yongxiang Li, Bing Feng, Peiyu Gao, Zhao Lin Cai, Makoto Fukuda, Mingshan Xue, Qingchun Tong, Yongjie Yang, Lan Liao, Jianming Xu, Chunmei Wang, Yanlin He, Yong Xu

Division of Basic Science Faculty Publications

Glucose is the basic fuel essential for maintenance of viability and functionality of all cells. However, some neurons —namely, glucose-inhibited (GI) neurons — paradoxically increase their firing activity in low-glucose conditions and decrease that activity in high-glucose conditions. The ionic mechanisms mediating electric responses of GI neurons to glucose fluctuations remain unclear. Here, we showed that currents mediated by the anoctamin 4 (Ano4) channel are only detected in GI neurons in the ventromedial hypothalamic nucleus (VMH) and are functionally required for their activation in response to low glucose. Genetic disruption of the Ano4 gene in VMH neurons reduced blood glucose …

The Role Of Gastronomy In Cultural Politics: Lesson Learned From Italy, Rifki Elindawati, Henny Saptatia Drajati Nugrahani

Journal of Strategic and Global Studies

Cultural politics is one of the efforts used by national governments in promoting culture in various countries to achieve their national interests. Italy tries to implement its cultural politics by seeing gastronomy as a diplomatic tool or gastrodiplomacy. This study attempts to seek answer for two research question, first is how does Italy intensively carry out a gastrodiplomacy as its cultural politics. The theory used in this research is the integral state of Gramsci's Hegemony. The research method that will be used in this paper is a descriptive qualitative research method analysis. Meanwhile, the data collection method used is document …

The Effect Of Sodium Bicarbonate On Acute Kidney Injury Markers During Physical Work In The Heat, Abdulaziz Abdulrahman A. Masoud, Fabiano Amorim, Christine Mermier, Michael Deyhle, Zidong Li

Health, Exercise, and Sports Sciences ETDs

Sodium bicarbonate supplementation (NaHCO₃) before physical work in the heat may reduce the risk of developing acute kidney injury (AKI). Purpose: To determine the effects of NaHCO₃ supplementation before a prolonged bout of physical work in the heat on AKI markers and kidney function. Method: A randomized, cross-over, double blinded design was conducted on 8 participants (3 females) who consumed NaHCO₃ (0.2 g/kg body weight) or placebo (CON) before prolonged (120 minutes) moderate intensity (~65% of maximal heart rate) physical work in the heat [40℃ and 23% relative humidity (RH)]. Blood and urine samples were collected …

Severe Hyperglycorrhachia And Status Epilepticus After Endoscopic Aqueductoplasty: Illustrative Case., Anand A. Dharia, Ahmad Masri, Jay F. Rilinger, Christian Kaufman

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: While hypoglycorrhachia is observed and managed frequently, there are few reports in the literature of clinically significant hyperglycorrhachia after neurosurgery. Understanding the effects and management of severe hyperglycorrhachia is important to the neurosurgeon and neurocritical care teams who care for patients in these rare scenarios.

OBSERVATIONS: The authors present the case of a 3-month-old male with congenital hydrocephalus who faced profound hyperglycorrhachia and status epilepticus after an endoscopic aqueductoplasty using an irrigant composed of lactated Ringer's solution with dextrose 5% in water. A multidisciplinary approach was developed to monitor and treat the patient's seizures and cerebrospinal fluid (CSF) osmolytes. …

Anoctamin 4 Channel Currents Activate Glucose-Inhibited Neurons In The Mouse Ventromedial Hypothalamus During Hypoglycemia, Longlong Tu, Jonathan C Bean, Yang He, Hailan Liu, Meng Yu, Hesong Liu, Nan Zhang, Na Yin, Junying Han, Nikolas A Scarcelli, Kristine M Conde, Mengjie Wang, Yongxiang Li, Bing Feng, Peiyu Gao, Zhao-Lin Cai, Makoto Fukuda, Mingshan Xue, Qingchun Tong, Yongjie Yang, Lan Liao, Jianming Xu, Chunmei Wang, Yanlin He, Yong Xu

Faculty, Staff and Student Publications

Glucose is the basic fuel essential for maintenance of viability and functionality of all cells. However, some neurons - namely, glucose-inhibited (GI) neurons - paradoxically increase their firing activity in low-glucose conditions and decrease that activity in high-glucose conditions. The ionic mechanisms mediating electric responses of GI neurons to glucose fluctuations remain unclear. Here, we showed that currents mediated by the anoctamin 4 (Ano4) channel are only detected in GI neurons in the ventromedial hypothalamic nucleus (VMH) and are functionally required for their activation in response to low glucose. Genetic disruption of the Ano4 gene in VMH neurons reduced blood …

Many Pediatric Patients With Gastroparesis Do Not Receive Dietary Education, Debra Eseonu, Deepa Dongarwar, Hamisu Salihu, Bruno P Chumpitazi, Robert J Shulman

Faculty, Staff and Students Publications

BACKGROUND: Gastroparesis is delayed gastric emptying in the absence of obstruction; dietary modifications are first-line treatment. However, we do not know the factors related to provision of dietary recommendations.

METHODS: We sought to determine how often pediatric patients with gastroparesis receive dietary education (from a gastroenterology provider vs dietitian), the recommendations given, and factors related to these outcomes. We performed a retrospective chart review of children 2- to 18-years-old managed by pediatric gastroenterology providers at our institution. Patient demographics and clinical data, dietary advice given (if any), and dietitian consultation (if any), practice location, and prokinetic use were captured. An …

Ancestry-Driven Metabolite Variation Provides Insights Into Disease States In Admixed Populations, Kaylia M Reynolds, Andrea R V R Horimoto, Bridget M Lin, Ying Zhang, Nuzulul Kurniansyah, Bing Yu, Eric Boerwinkle, Qibin Qi, Robert Kaplan, Martha Daviglus, Lifang Hou, Laura Y Zhou, Jianwen Cai, Saame Raza Shaikh, Tamar Sofer, Sharon R Browning, Nora Franceschini

Faculty, Staff and Student Publications

BACKGROUND: Metabolic pathways are related to physiological functions and disease states and are influenced by genetic variation and environmental factors. Hispanics/Latino individuals have ancestry-derived genomic regions (local ancestry) from their recent admixture that have been less characterized for associations with metabolite abundance and disease risk.

METHODS: We performed admixture mapping of 640 circulating metabolites in 3887 Hispanic/Latino individuals from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Metabolites were quantified in fasting serum through non-targeted mass spectrometry (MS) analysis using ultra-performance liquid chromatography-MS/MS. Replication was performed in 1856 nonoverlapping HCHS/SOL participants with metabolomic data.

RESULTS: By leveraging local ancestry, this …

Evaluation Of The Efficacy Of A Telehealth Support Forum For Reducing Distress In Informal Caregivers Of Patients With Glioblastoma, Stacey D. Green

Dissertations

Glioblastoma is incurable, deadly, and disabling. Informal caregivers of glioblastoma patients face an unpredictable, laborious, costly, and distressing experience. Supported caregivers have less distress and improved caregiver mastery. Often times, caregivers are unable to attend support groups, increasing risk of adverse events for caregiver and patient. This increased risk highlights a need for increased access to support. The purpose of this project was to determine if distressed caregivers of glioblastoma patients at an academic medical center would report reduced distress after participating in telehealth support forums over a period of four weeks. The health belief model was used to implement …

Examining The Outcomes Of Project Echo® As An Interprofessional Community Of Practice For Pediatric Feeding Clinicians, Madeline Raatz, Elizabeth C Ward, Perrin Moss, Claire Reilly, Nadine Frederiksen, Corrine Dickinson, Sally Clarke, Kelly Beak, Jeanne Marshall

Project ECHO Bibliography

Project ECHO® is a virtual, interprofessional, cased-based peer-learning model. To date, no studies have explored ECHO as a model for pediatric feeding education. This study examined the outcomes of establishing a pediatric feeding ECHO network. Using a prospective, mixed-methods design, two cohorts of allied health professionals were recruited. Each cohort participated in eight, 90-min videoconference sessions incorporating a didactic presentation and clinical case presentation. The case was presented by a participant, with questions and recommendations provided by the ECHO network. Participants completed: (1) a learning needs analysis before the ECHO series, (2) a self-reported confidence questionnaire pre, post, and 3-month …

Faith And Information To Treat Hypertension, Tiffany Bell

Student Scholarly Projects

Practice Problem: The prevalence of stroke and hypertension (HTN) in African Americans in the United States is among the highest in the world (American Heart Association, n.d.) with cultural norms as a contributing factor.

PICOT: The PICOT question that guided this project was in African American adults (>18 y/o) (P), how does a faith-based hypertension management program (I), compared to standard hypertension management (C), affect blood pressure measurements (O) within an 8-week timeframe (T)?

Evidence: The integration of motivational interviewing with therapeutic lifestyle changes along with HTN education using a community-based participatory approach delivered in the …

Use Of A Performance-Based Occupational Therapy Assessment Of Executive Function With The Homeless Population: A Case Report, Emily Raphael-Greenfield, Kimberlee Baltich, Tess Wilson, Rebecca Lowinger

The Open Journal of Occupational Therapy

Background: An estimated 25% of the homeless population has a mental illness, which means that many experience cognitive problems that adversely impact basic and instrumental activities of daily living and goal attainment. This case report focused on the experience of an individual living in transitional housing who was evaluated with a performance-based occupational therapy assessment in the context of community-based interdisciplinary psychosocial care provided by a robust occupational therapy fieldwork program.

Method: This case report generally followed the CARE Case Report Guidelines and highlights the use of a standardized performance-based assessment and follow-up care suggested by test outcomes. …

Feasibility Of A Stress Reduction Program Among Foster Youth In College, Alexis Melinda Ferioli Morin, Jennifer E. Lape

The Open Journal of Occupational Therapy

Background: Foster youth endure traumatic adversities, which can lead to obstacles when transitioning to young adulthood and pursuing postsecondary education. This vulnerable population is required to navigate independent living while also managing stress that commonly arises from postsecondary education.

Method: A pre test, post test pilot design was employed to determine the potential impact and feasibility of an evidenced-based multi-factorial stress management program in reducing foster youth’s perceived stress during postsecondary education. Participants (n = 3) received one, 90-min individual occupational therapy session weekly over 6 weeks. Author-generated stress management surveys along with the Perceived Stress Scale …

Reflections From The Other Side Of Acute Care, Debbie Amini

The Open Journal of Occupational Therapy

An occupational therapist of 40 years experiences a traumatic event during her time in an acute care hospital. She journeys through a host of life-altering experiences, including cognitive decline, delusion, paranoia, and an inability to engage in her desired occupations. While on this journey and during reflections following her return home, she is able to see more clearly how an occupational therapist may have assisted with several of the major concerns she was experiencing, thus improving her well-being and quality of life. She is an Assistant Editor for the Open Journal of Occupational Therapy (OJOT) and this is her story.

Global, Regional, And National Burden Of Diabetes From 1990 To 2021, With Projections Of Prevalence To 2050: A Systematic Analysis For The Global Burden Of Disease Study 2021, Kanyin Liane Ong, Lauryn K. Stafford, Susan A. Mclaughlin, Edward J. Boyko, Stein Emil Vollset, Amanda E. Smith, Bronte E. Dalton, Joe Duprey, Jessica A. Cruz, Hailey Hagins, Paulina A. Lindstedt, Amirali Aali, Yohannes Habtegiorgis Abate, Melsew Dagne Abate, Mohammadreza Abbasian, Zeinab Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Samar Abd Elhafeez, Rami Abd-Rabu, Deldar Morad Abdulah, Abu Yousuf Md Abdullah, Veincent Christian Pepito

Ateneo School of Medicine and Public Health Publications

Background

Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of type 1 and type 2 diabetes in 2021, the proportion of the type 2 diabetes burden attributable to selected risk factors, and projections of diabetes prevalence through 2050.

Methods

Estimates of diabetes prevalence and burden were computed in …

Estudio Termoquímico Asistido Por Computadora De Los Polifenoles Presentes En La Fresa [Thermochemical Computer Assisted Study Of Polyphenols Presented In Strawberry], Federico Lopez, Jeimmy Rocio Bonilla Méndez, Luis Ricárdez Sandoval, Hiram Moya, Daniela Mainardi, Arturo González Quiroga, Jeffrey Leon-Pulido

Manufacturing & Industrial Engineering Faculty Publications

Las fresas son un alimento importante en Latinoamérica debido a sus componentes químicos, puesto que son una considerable fuente de calorías y polifenoles. Estos elementos son útiles por su capacidad antioxidante y otras propiedades beneficiosas para la salud. Sin embargo, la presión y la temperatura pueden llegar a afectar la integridad molecular de estos componentes, por lo tanto, en el proceso de producción de diferentes productos basados en fresas, se requiere estudiar las propiedades termoquímicas de los diferentes polifenoles presentes en esta fruta. Para ello, se extrajeron datos de las principales familias de polifenoles, antocianinas, flavanoles, flavonoles, ácidos hidroxibenzoicos y …

Lower Urinary Tract Symptoms In Depression: A Review, Danyon J. Anderson, Alise Aucoin, Colton R. Toups, Devin Cormier, Matthew Mcdonald, Jamal Hasoon, Omar Viswanath, Alan D. Kaye, Ivan Urits

School of Medicine Faculty Publications

Lower Urinary Tract Symptoms (LUTS) are frequently present in the general population as patients age with approximately a third of individuals experiencing LUTS during their lifetime. LUTS can be further defined as having any of the following symptoms: urinary hesitancy, straining, nocturia, increased urination frequency, and dysuria. LUTS has the potential for patients to contribute their symptoms to what can normally occur as we age. This can lead to a decrease in patients seeking care and could negatively impact patients’ health-related quality of life (HRQL). In conjunction with LUTS, we obtained from our analysis that LUTS and depression are closely …

Long-Term Outcomes In Patients With Chronic Lymphocytic Leukemia Treated With Ibrutinib: Focus On Hypertension And Cardiovascular Toxicity, Max J Gordon, Jade E Jones, Binsah George, Christine Peterson, Jan A Burger, Nitin Jain, Michael Keating, William G Wierda, Jean-Bernard Durand, Alessandra Ferrajoli

Faculty, Staff and Student Publications

BACKGROUND: Continuous ibrutinib administration is needed to maintain efficacy in patients with chronic lymphocytic leukemia (CLL) and, as such, long-term toxicity is a concern. The authors report the 5-year follow-up of patients with CLL who received treatment with ibrutinib with a focus on hypertension and cardiovascular toxicities.

METHODS: Patient characteristics were assessed, including blood pressure, cardiovascular disease, disease progression, and death. Univariate logistic regression analysis assessed the relation of patient characteristics and the development of new or worsened hypertension. The incidence of hypertensive outcomes was evaluated using competing risk. Survival was estimated using the Kaplan-Meier method.

RESULTS: Three hundred patients …

Prevalence Of Overweight And Obesity Among Students Of Intermediate Schools In Basra : Prevalence Of Overweight And Obesity Among Students Of Intermediate Schools In Basra, Ziyad Shwaish, Mahmood Alatbee, Wefak Hasan Al-Kawaz, Nada Hasan Al-Kawaz

Iraqi National Journal of Medicine

Background: Obesity is one of the most serious public health challenges of the 21st century and represents a serious health problem for low- and middle-income countries, particularly in urban settings. Its prevalence has increased at an alarming rate. Globally, more than 340 million children and adolescents aged 5–19 years are overweight or obese, and approximately two-third of them live in developing countries. Aim: The present study was implemented to assess the prevalence rates of overweight and obesity among adolescents in intermediate schools in Basrah, Iraq. Methods: A cross-sectional study was conducted during the second semester (between January 15 and May …

Ototoxicity In Cancer Patients On Cisplatin Therapy Attending Basrah Oncology Centre: A Cohort Study: Ototoxicity In Cancer Patients On Cisplatin Therapy, Hasanain Al-Ali, Jasim Al-Asadi, Abdulrazzaq Alrubaye, Hasson Ali

Iraqi National Journal of Medicine

Background: Cisplatin is a chemotherapeutic agent that is used extensively for the treatment of a broad spectrum of tumors. However, progressive irreversible side effects of Cisplatin, including ototoxicity, have been reported. Methods: A cohort study was implemented from 1 April to 30 August 2015 to study the association between Cisplatin chemotherapy and sensory-neural hearing loss as the major and most important sign of ototoxicity. The cohort group included cancer patients treated with Cisplatin, while patients on Carboplatin were the control group. Cisplatin and Carboplatin belong to alkylating platinum chemotherapy drugs, which are used to treat various malignant solid tumors. Data …

Correlation Of Placental Weight With Neonatal Weight And Hba1c In Normal Sudanese Pregnant Ladies In Alban-Jaded Teaching Hospital : Correlation Of Placental Weight With Neonatal Weight And Hba1c, Ibrahim Ali, Asim Osman, Wala Ahmed

Iraqi National Journal of Medicine

Background: The placenta is a life-supporting organ for the growing fetus. Several studies have highlighted the relationship between placental weight and neonatal birth weight; however, the role of glycosylated hemoglobin (HbA1c) has not been addressed. Aim: The study aimed to determine the relationship between the placental weight, neonatal birth weight, and HbA1c at term pregnancy in a Sudanese hospital. Methods: This was a cross-sectional hospital-based study conducted at Al Ban-Jaded Hospital between November and December 2022. Data, including the gestational age at delivery (in weeks), parity, mode of delivery, fetal birth weight, placental weight, fetal gender, and presence or absence …

Phase 1b Study Of Combined Selinexor And Eribulin For The Treatment Of Advanced Solid Tumors And Triple-Negative Breast Cancer, Blessie Elizabeth Nelson, Sadia Saleem, Senthil Damodaran, Neeta Somaiah, Sarina Piha-Paul, Julia Ann Moore, Bulent Yilmaz, Deby Ogbonna, Daniel D Karp, Ecaterina Dumbrava, Apostolia M Tsimberidou, David S Hong, Jordi Rodon Ahnert, Denái R Milton, Xiaofeng Zheng, Daniel J Booser, Nuhad K Ibrahim, Anthony P Conley, Priya Bhosale, Cristhiam M Rojas Hernandez, Debasish Tripathy, Aung Naing, Funda Meric-Bernstam

Faculty, Staff and Student Publications

BACKGROUND: Selinexor (KPT-330) is a potent inhibitor of exportin 1 (XPO1), in turn inhibiting tumor growth. Selinexor enhances the antitumor efficacy of eribulin in triple-negative breast cancer (TNBC) in vitro and in vivo. Given the unmet medical need in TNBC and sarcoma, the authors explored the safety and efficacy of this combination.

METHODS: The authors conducted a phase 1b trial of combined selinexor and eribulin using a 3 + 3 dose-escalation design in patients who had advanced solid tumors and in those who had TNBC in a dose-expansion cohort.

RESULTS: Patients with TNBC (N = 19), sarcoma (N = 9), …

Nutritional Characteristics, Microbial Loads And Consumer Acceptability Of Cookies Enriched With Insect (Ruspolia Differens) Meal, Brian O. Ochieng, Joseph O. Anyango, Fathiya M. Khamis, Sunday Ekesi, James Peter Egonyu, Sevgan Subramanian, John M. Nduko, Dorothy Nakimbugwe, Xavier Cheseto, Chrysantus M. Tanga

All Peer-Reviewed Publications

Utilization of Ruspolia differens Serville as functional food ingredient is rapidly gaining popularity. This study evaluated the nutrient quality, microbial safety and consumers’ acceptability of cereal-based cookies fortified with various processed products of R. differens meals. Cookies fortified with blanched, boiled, and toasted R. differens meals had higher protein, fat and energy levels, respectively, than the control cookies. Enrichment of cookies with differentially processed R. differens meals had elevated levels of isoleucine and leucine. Omega-3 fatty acid, methyl (9Z,12Z,15Z)-octadecatrienoate, was detected only in cookies prepared from wheat-insect meals blends. Blanched and boiled R. differens meal significantly (p < 0.05) boosted iron (1.70-folds) and zinc (1.12–1.16-folds) contents of the cookies. The cookie products had reduced Enterobacteriaceae, S. aureus, yeast and mould with permissible exposure limits for human consumption. The overall acceptability of insect-enriched cookie product by male and female respondents ranged between 57 and 80%. The survey revealed that the flavour, colour, mouthfeels and texture of the cookie products were important motivation for consumers to accept grasshoppers as a food source. Further research on the flavour of cookie products enriched with grasshopper meal would be required to increase acceptability to market-driven consumer appealing food products.

Deletion Of Taf1 And Taf5 In Zebrafish Capitulate Cardiac And Craniofacial Abnormalities Associated With Tafopathies Through Perturbations In Metabolism, Jamison Leid, Ryan Gray, Peter Rakita, Andrew L Koenig, Rohan Tripathy, James A J Fitzpatrick, Charles Kaufman, Lilianna Solnica-Krezel, Kory J Lavine

2020-Current year OA Pubs

Intellectual disability is a neurodevelopmental disorder that affects 2-3% of the general population. Syndromic forms of intellectual disability frequently have a genetic basis and are often accompanied by additional developmental anomalies. Pathogenic variants in components of TATA-binding protein associated factors (TAFs) have recently been identified in a subset of patients with intellectual disability, craniofacial hypoplasia, and congenital heart disease. This syndrome has been termed as a TAFopathy and includes mutations in TATA binding protein (TBP), TAF1, TAF2, and TAF6. The underlying mechanism by which TAFopathies give rise to neurodevelopmental, craniofacial, and cardiac abnormalities remains to be defined. Through a forward …

Reimagining Disability: A Call To Action, Paritosh Joshi, Julia Pappageorge

Developmental Disabilities Network Journal

This article focuses on how the medical profession, organizations, and universities should incorporate the social model of disability into their regulations and policies to advance justice for individuals with disabilities. Traditionally, disability has been viewed through the medical model, which postulates that one’s individual body or mind is medically impaired and diminishes the person’s quality of life. The model overemphasizes individual difference or disability diagnosis as something that should be treated at an individual level through medical intervention, and ignores social factors that impact the development of physical and mental conditions. Moreover, this pervasive attitude towards disability permeates institutions and …

Review Of Dan C. Shahar’S Why It's Ok To Eat Meat And Per Bauhn’S Animal Suffering, Human Rights, And The Virtue Of Justice, Josh Milburn

Between the Species

It’s tricky to find decent defences of meat-eating of the kind practiced by most westerners. I was thus intrigued to pick up two short books defending meat-eating. Dan Shahar’s Why It’s Ok to Eat Meat (2022) is in Routledge’s series of short books called Why It's OK: The Ethics and Aesthetics of How We Live. Per Bauhn’s Animal Suffering, Human Rights, and the Virtue of Justice (2023) is from Palgrave Pivot, which publishes books falling somewhere between journal articles and monographs. Shahar’s book is worth reading: it’s well-written, raising interesting questions, and offering a coherent defence of meat. Bauhn’s book …

Incorporating Poi As A Therapeutic Modality For Preschool Aged Children In The Care Clinic, Danielle Zirkle

Department of Occupational Therapy Entry-Level Capstone Projects

No abstract provided.

Developing A Person-Centred Approach In Dentistry Beyond Nhs Recall Intervals: A Commentary, Ian Mills, Sasha Scambler, Patricia Neville, Koula Asimakopoulou

Peninsula Dental School

Person-centred care (PCC) is acknowledged as a fundamental dimension of quality within health care and provides significant benefits for patients and clinicians. Models of PCC have primarily been developed from the medical literature, with limited consideration of their application within dentistry. The Personalised Care Institute was established to deliver education and training on PCC and is working with the Office of the Chief Dental Officer for England to develop resources on shared decision-making (SDM) to promote tailored recall intervals.This paper seeks to promote the value of PCC and SDM in delivering high-quality care but cautions against the use of generic …